THOP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1formation of translation preinitiation complex (GO:0001731)6.11712007
2mitotic chromosome condensation (GO:0007076)5.10340493
3DNA double-strand break processing (GO:0000729)5.09606376
4regulation of mitochondrial translation (GO:0070129)5.04118640
5DNA unwinding involved in DNA replication (GO:0006268)4.83555685
6proline biosynthetic process (GO:0006561)4.83311727
7DNA replication-dependent nucleosome assembly (GO:0006335)4.80468247
8DNA replication-dependent nucleosome organization (GO:0034723)4.80468247
9maturation of SSU-rRNA (GO:0030490)4.74380362
10DNA strand elongation involved in DNA replication (GO:0006271)4.55451394
11DNA replication initiation (GO:0006270)4.47834424
12mitotic nuclear envelope disassembly (GO:0007077)4.41024659
13DNA strand elongation (GO:0022616)4.25229584
14regulation of mammary gland epithelial cell proliferation (GO:0033599)4.21213960
15DNA replication checkpoint (GO:0000076)4.19484478
16spliceosomal tri-snRNP complex assembly (GO:0000244)4.18345884
17membrane disassembly (GO:0030397)4.14196824
18nuclear envelope disassembly (GO:0051081)4.14196824
19translesion synthesis (GO:0019985)4.03091147
20negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.01562747
21nucleobase biosynthetic process (GO:0046112)3.99644502
22telomere maintenance via semi-conservative replication (GO:0032201)3.92273545
23postreplication repair (GO:0006301)3.91637403
24ribosomal large subunit biogenesis (GO:0042273)3.86931587
25folic acid-containing compound biosynthetic process (GO:0009396)3.86129250
26regulation of histone H3-K9 methylation (GO:0051570)3.85210420
27protein localization to kinetochore (GO:0034501)3.84872207
28nuclear pore organization (GO:0006999)3.78466354
29peptidyl-arginine omega-N-methylation (GO:0035247)3.75208148
30mitotic sister chromatid segregation (GO:0000070)3.74225941
31regulation of oxidative phosphorylation (GO:0002082)3.68007990
32translational initiation (GO:0006413)3.66132605
33IMP biosynthetic process (GO:0006188)3.64808253
34COPI coating of Golgi vesicle (GO:0048205)3.64211377
35Golgi transport vesicle coating (GO:0048200)3.64211377
36heterochromatin organization (GO:0070828)3.63769443
37nuclear pore complex assembly (GO:0051292)3.63619971
38viral transcription (GO:0019083)3.62172671
39protein localization to chromosome, centromeric region (GO:0071459)3.61237587
40regulation of gene silencing by RNA (GO:0060966)3.59651769
41regulation of posttranscriptional gene silencing (GO:0060147)3.59651769
42regulation of gene silencing by miRNA (GO:0060964)3.59651769
43translational termination (GO:0006415)3.55303864
44cellular protein complex localization (GO:0034629)3.53638578
45somatic diversification of immune receptors via somatic mutation (GO:0002566)3.52297565
46somatic hypermutation of immunoglobulin genes (GO:0016446)3.52297565
47ribosomal small subunit assembly (GO:0000028)3.51320400
48L-serine metabolic process (GO:0006563)3.50245460
49nucleobase-containing small molecule interconversion (GO:0015949)3.50230416
50proline metabolic process (GO:0006560)3.48694464
51rRNA transcription (GO:0009303)3.48105582
52chaperone-mediated protein complex assembly (GO:0051131)3.46979847
53negative regulation of mRNA processing (GO:0050686)3.46232635
54negative regulation of RNA splicing (GO:0033119)3.42902881
55purine nucleobase biosynthetic process (GO:0009113)3.37975998
56DNA catabolic process, exonucleolytic (GO:0000738)3.36988164
57protein-DNA complex disassembly (GO:0032986)3.36676449
58nucleosome disassembly (GO:0006337)3.36676449
59translational elongation (GO:0006414)3.34915621
60intra-S DNA damage checkpoint (GO:0031573)3.34056279
61sister chromatid segregation (GO:0000819)3.33853277
62histone arginine methylation (GO:0034969)3.31826521
63positive regulation of chromosome segregation (GO:0051984)3.29344596
64chromosome condensation (GO:0030261)3.28783038
65telomere maintenance via recombination (GO:0000722)3.27527782
66regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.27320865
67protein complex localization (GO:0031503)3.26025589
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.25324976
69folic acid metabolic process (GO:0046655)3.23328815
70regulation of translational elongation (GO:0006448)3.23049947
71binding of sperm to zona pellucida (GO:0007339)3.22534385
72ribosome assembly (GO:0042255)3.20744452
73mitotic metaphase plate congression (GO:0007080)3.20423457
74nuclear envelope organization (GO:0006998)3.19688167
75ribonucleoprotein complex biogenesis (GO:0022613)3.18563159
76nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.18022334
77spliceosomal snRNP assembly (GO:0000387)3.17608175
78establishment of integrated proviral latency (GO:0075713)3.16512611
79IMP metabolic process (GO:0046040)3.16476744
80regulation of translational fidelity (GO:0006450)3.16456416
81DNA duplex unwinding (GO:0032508)3.15919972
82negative regulation of mRNA metabolic process (GO:1903312)3.15262336
83DNA topological change (GO:0006265)3.14492231
84regulation of centriole replication (GO:0046599)3.14466968
85DNA geometric change (GO:0032392)3.13681015
86ribosome biogenesis (GO:0042254)3.12467226
87mitochondrial fusion (GO:0008053)3.11462429
88chromatin remodeling at centromere (GO:0031055)3.11305833
89histone exchange (GO:0043486)3.11016592
90mitotic recombination (GO:0006312)3.09621115
91regulation of centrosome cycle (GO:0046605)3.09314162
92regulation of histone H3-K27 methylation (GO:0061085)3.07137314
93peptidyl-arginine methylation (GO:0018216)3.07087975
94peptidyl-arginine N-methylation (GO:0035246)3.07087975
95pore complex assembly (GO:0046931)3.06538362
96ATP-dependent chromatin remodeling (GO:0043044)3.05274092
97DNA conformation change (GO:0071103)3.04509873
98nucleotide-excision repair, DNA gap filling (GO:0006297)3.04426761
99chromatin assembly or disassembly (GO:0006333)3.03777906
100DNA deamination (GO:0045006)3.03479836
101ribosomal small subunit biogenesis (GO:0042274)3.03232457
102nuclear envelope reassembly (GO:0031468)3.02696405
103mitotic nuclear envelope reassembly (GO:0007084)3.02696405
104sperm-egg recognition (GO:0035036)3.02166020
105telomere maintenance via telomere lengthening (GO:0010833)3.01811563
106regulation of helicase activity (GO:0051095)2.98043511
107apoptotic process involved in morphogenesis (GO:0060561)2.97470624
108regulation of chromosome segregation (GO:0051983)2.97226399
109termination of RNA polymerase II transcription (GO:0006369)2.97096581
110chromatin assembly (GO:0031497)2.96607606
111rRNA processing (GO:0006364)2.96570820
112retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.96546456
113DNA packaging (GO:0006323)2.94825939
114regulation of translational termination (GO:0006449)2.93634087
115CENP-A containing nucleosome assembly (GO:0034080)2.93045624
116negative regulation of chromosome segregation (GO:0051985)2.92866621
117DNA synthesis involved in DNA repair (GO:0000731)2.92408700
118viral mRNA export from host cell nucleus (GO:0046784)2.91546949
119protein maturation by protein folding (GO:0022417)2.91375632
120cellular protein complex disassembly (GO:0043624)2.90075406
121positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.88542828
122positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.88542828
123positive regulation of mitotic sister chromatid separation (GO:1901970)2.88542828
124activation of Rac GTPase activity (GO:0032863)2.88462152
125rRNA metabolic process (GO:0016072)2.88438704
126pre-miRNA processing (GO:0031054)2.86682486
127synaptonemal complex assembly (GO:0007130)2.86323351
128mitochondrial DNA metabolic process (GO:0032042)2.86279583
129positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.80679407
130negative regulation of cell size (GO:0045792)2.79727267
131mitotic G1 DNA damage checkpoint (GO:0031571)2.79435573
132protein retention in ER lumen (GO:0006621)2.79025487
133pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.70839375
134positive regulation of DNA-dependent DNA replication (GO:2000105)2.70354480
135pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.69080628
136regulation of mitotic spindle organization (GO:0060236)2.68393480
137mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.68074453
138maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.67877050
139planar cell polarity pathway involved in neural tube closure (GO:0090179)2.67060246
140serine family amino acid biosynthetic process (GO:0009070)2.65921182
141adherens junction assembly (GO:0034333)2.65533752
142regulation of RNA export from nucleus (GO:0046831)2.65290209
143pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.61516301
144transcription from mitochondrial promoter (GO:0006390)2.60857710
145focal adhesion assembly (GO:0048041)2.60182590
146cell-substrate adherens junction assembly (GO:0007045)2.60182590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.17443707
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.05659115
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.03925481
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.02681539
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.69906965
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27530865
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.17126529
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.71374838
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.69370399
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63439619
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.46591991
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.34976259
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27417647
14XRN2_22483619_ChIP-Seq_HELA_Human2.26436470
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.20047443
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.20047443
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.20047443
18* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14920312
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11256025
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.05753929
21LXR_22292898_ChIP-Seq_THP-1_Human2.05177005
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.98724843
23SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.94314484
24MYC_22102868_ChIP-Seq_BL_Human1.89965118
25AR_21909140_ChIP-Seq_LNCAP_Human1.89351301
26* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87779427
27NANOG_18555785_ChIP-Seq_MESCs_Mouse1.87289223
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.82007068
29SOX2_18555785_ChIP-Seq_MESCs_Mouse1.81285926
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.77269815
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.76097314
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73281687
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67382031
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67107399
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66537657
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.63758025
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.63406773
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62527347
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61465732
40GABP_19822575_ChIP-Seq_HepG2_Human1.60568167
41* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59462576
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57828705
43VDR_23849224_ChIP-Seq_CD4+_Human1.56794306
44KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.56227073
45RACK7_27058665_Chip-Seq_MCF-7_Human1.54091126
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52648221
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51609630
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51208675
49* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50892686
50* TET1_21451524_ChIP-Seq_MESCs_Mouse1.49335142
51TTF2_22483619_ChIP-Seq_HELA_Human1.49325548
52* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47138399
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46471992
54FOXP3_21729870_ChIP-Seq_TREG_Human1.46267263
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46096726
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.45676672
57DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.44575791
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42778976
59CIITA_25753668_ChIP-Seq_RAJI_Human1.41812966
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41249816
61TCF3_18692474_ChIP-Seq_MEFs_Mouse1.39778000
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39457775
63NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.36673936
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36647975
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35955441
66DCP1A_22483619_ChIP-Seq_HELA_Human1.35748261
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34602923
68CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.34413115
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33815484
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31936584
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.31694836
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31693185
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30158826
74KDM2B_26808549_Chip-Seq_DND41_Human1.25366744
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24265733
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24187347
77KDM5A_27292631_Chip-Seq_BREAST_Human1.21746458
78TCF7_22412390_ChIP-Seq_EML_Mouse1.20302812
79ZNF263_19887448_ChIP-Seq_K562_Human1.20132689
80SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.19320955
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.19125860
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16493072
83VDR_21846776_ChIP-Seq_THP-1_Human1.16174048
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.15117433
85UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14659570
86YY1_22570637_ChIP-Seq_MALME-3M_Human1.13750823
87SA1_27219007_Chip-Seq_ERYTHROID_Human1.13551453
88TCF3_18692474_ChIP-Seq_MESCs_Mouse1.12567394
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09812879
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08374731
91* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04240814
92SMC4_20622854_ChIP-Seq_HELA_Human1.04115847
93NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03907603
94KDM2B_26808549_Chip-Seq_K562_Human1.03829211
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03438453
96HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02804957
97OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02199194
98NCOR1_26117541_ChIP-Seq_K562_Human1.01961700
99CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01738405
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01727094
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01316621
102KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01011371
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00794816
104ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99598597
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99281749
106TP53_22127205_ChIP-Seq_IMR90_Human0.98638811
107SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98442343
108SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98387038
109CREB1_26743006_Chip-Seq_LNCaP_Human0.98297907
110SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97992721
111PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97924891
112RARA_24833708_ChIP-Seq_LIVER_Mouse0.97470932
113P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96989122
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96892021
115SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.96232617
116MAF_26560356_Chip-Seq_TH2_Human0.95916284
117E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95814393
118EGR1_19374776_ChIP-ChIP_THP-1_Human0.95173505
119FOXP1_21924763_ChIP-Seq_HESCs_Human0.94577937
120SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94200548
121POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.93998659
122SOX2_18692474_ChIP-Seq_MESCs_Mouse0.90307806
123ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89706632
124ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89095294
125NANOG_21062744_ChIP-ChIP_HESCs_Human0.88375349
126SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.87437881
127CTCF_18555785_ChIP-Seq_MESCs_Mouse0.86439616
128ELF1_17652178_ChIP-ChIP_JURKAT_Human0.85933436
129RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84934235
130TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82762485
131* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82567460
132ATF3_27146783_Chip-Seq_COLON_Human0.81016265
133ELK3_25401928_ChIP-Seq_HUVEC_Human0.79952773
134PHF8_20622854_ChIP-Seq_HELA_Human0.79633521
135CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.78986630
136P68_20966046_ChIP-Seq_HELA_Human0.77438593

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.10711375
2MP0003693_abnormal_embryo_hatching3.99841437
3MP0003111_abnormal_nucleus_morphology3.83729386
4MP0004957_abnormal_blastocyst_morpholog3.79946402
5MP0003077_abnormal_cell_cycle3.64064727
6MP0008057_abnormal_DNA_replication3.10298428
7MP0005410_abnormal_fertilization3.04568994
8MP0010030_abnormal_orbit_morphology2.83779640
9MP0005451_abnormal_body_composition2.82290495
10MP0002877_abnormal_melanocyte_morpholog2.76172989
11MP0008058_abnormal_DNA_repair2.70106919
12MP0008932_abnormal_embryonic_tissue2.68424672
13MP0003123_paternal_imprinting2.67836955
14MP0010352_gastrointestinal_tract_polyps2.62990119
15MP0001730_embryonic_growth_arrest2.53578109
16MP0002653_abnormal_ependyma_morphology2.46937749
17MP0004185_abnormal_adipocyte_glucose2.35744783
18MP0008877_abnormal_DNA_methylation2.22971275
19MP0005623_abnormal_meninges_morphology2.20723198
20MP0008007_abnormal_cellular_replicative2.20660942
21MP0000350_abnormal_cell_proliferation2.16499342
22MP0010234_abnormal_vibrissa_follicle2.07527829
23MP0004272_abnormal_basement_membrane2.06700953
24MP0000537_abnormal_urethra_morphology2.02048958
25MP0001348_abnormal_lacrimal_gland2.01709514
26MP0004858_abnormal_nervous_system1.96829591
27MP0000003_abnormal_adipose_tissue1.91661217
28MP0004197_abnormal_fetal_growth/weight/1.90667056
29MP0001929_abnormal_gametogenesis1.88029637
30MP0001697_abnormal_embryo_size1.83764652
31MP0002085_abnormal_embryonic_tissue1.80372147
32MP0002084_abnormal_developmental_patter1.80056128
33MP0000678_abnormal_parathyroid_gland1.79930482
34MP0001346_abnormal_lacrimal_gland1.75744300
35MP0005408_hypopigmentation1.75592090
36MP0003705_abnormal_hypodermis_morpholog1.68650181
37MP0005380_embryogenesis_phenotype1.68175849
38MP0001672_abnormal_embryogenesis/_devel1.68175849
39MP0002210_abnormal_sex_determination1.67216303
40MP0002277_abnormal_respiratory_mucosa1.66686264
41MP0002396_abnormal_hematopoietic_system1.62090658
42MP0002098_abnormal_vibrissa_morphology1.61900468
43MP0002080_prenatal_lethality1.61840720
44MP0004133_heterotaxia1.59938051
45MP0003698_abnormal_male_reproductive1.57387986
46MP0010307_abnormal_tumor_latency1.55146392
47MP0001145_abnormal_male_reproductive1.54771666
48MP0009278_abnormal_bone_marrow1.50097871
49MP0003890_abnormal_embryonic-extraembry1.48936426
50MP0002086_abnormal_extraembryonic_tissu1.48363555
51MP0001293_anophthalmia1.47591383
52MP0003984_embryonic_growth_retardation1.47153087
53MP0002088_abnormal_embryonic_growth/wei1.46041099
54MP0009379_abnormal_foot_pigmentation1.39778002
55MP0008260_abnormal_autophagy1.39305963
56MP0003119_abnormal_digestive_system1.38339599
57MP0005058_abnormal_lysosome_morphology1.35989208
58MP0000371_diluted_coat_color1.32899606
59MP0008789_abnormal_olfactory_epithelium1.31189831
60MP0003136_yellow_coat_color1.29250299
61MP0000313_abnormal_cell_death1.28951925
62MP0003453_abnormal_keratinocyte_physiol1.28077556
63MP0004233_abnormal_muscle_weight1.27488600
64MP0003283_abnormal_digestive_organ1.26953069
65MP0002160_abnormal_reproductive_system1.25927788
66MP0000653_abnormal_sex_gland1.25881919
67MP0000462_abnormal_digestive_system1.19101759
68MP0001661_extended_life_span1.19015890
69MP0009672_abnormal_birth_weight1.18930730
70MP0005375_adipose_tissue_phenotype1.16735219
71MP0005076_abnormal_cell_differentiation1.15217107
72MP0002282_abnormal_trachea_morphology1.12546812
73MP0002796_impaired_skin_barrier1.12221701
74MP0003806_abnormal_nucleotide_metabolis1.11405600
75MP0005499_abnormal_olfactory_system1.10219079
76MP0005394_taste/olfaction_phenotype1.10219079
77MP0000428_abnormal_craniofacial_morphol1.08541643
78MP0005666_abnormal_adipose_tissue1.08208771
79MP0002161_abnormal_fertility/fecundity1.08155405
80MP0003121_genomic_imprinting1.07146664
81MP0005023_abnormal_wound_healing1.07006753
82MP0000566_synostosis1.04599667
83MP0009053_abnormal_anal_canal1.04128460
84MP0005621_abnormal_cell_physiology1.03437941
85MP0002019_abnormal_tumor_incidence1.02513274
86MP0003315_abnormal_perineum_morphology1.01855106
87MP0009840_abnormal_foam_cell1.00906197
88MP0003115_abnormal_respiratory_system1.00202538
89MP0001186_pigmentation_phenotype0.99457124
90MP0003786_premature_aging0.98069839
91MP0009703_decreased_birth_body0.98045077
92MP0009333_abnormal_splenocyte_physiolog0.97829908
93MP0002132_abnormal_respiratory_system0.97720906
94MP0000358_abnormal_cell_content/0.96716779
95MP0005501_abnormal_skin_physiology0.95710136
96MP0002089_abnormal_postnatal_growth/wei0.95304215
97MP0002075_abnormal_coat/hair_pigmentati0.93683570
98MP0006292_abnormal_olfactory_placode0.92926981
99MP0000490_abnormal_crypts_of0.91999031
100MP0005384_cellular_phenotype0.91970337
101MP0003861_abnormal_nervous_system0.90505827
102MP0003566_abnormal_cell_adhesion0.90498435
103MP0002092_abnormal_eye_morphology0.90214512
104MP0006035_abnormal_mitochondrial_morpho0.90028568
105MP0005670_abnormal_white_adipose0.90015672
106MP0003942_abnormal_urinary_system0.89588026
107MP0003385_abnormal_body_wall0.89443695
108MP0000751_myopathy0.88177516
109MP0003718_maternal_effect0.87510273
110MP0000759_abnormal_skeletal_muscle0.87059812
111MP0001849_ear_inflammation0.86953878
112MP0004808_abnormal_hematopoietic_stem0.86036879
113MP0003448_altered_tumor_morphology0.83897504
114MP0002111_abnormal_tail_morphology0.83833911
115MP0000579_abnormal_nail_morphology0.83280601
116MP0000013_abnormal_adipose_tissue0.83164394
117MP0003937_abnormal_limbs/digits/tail_de0.81666369
118MP0002697_abnormal_eye_size0.80120576
119MP0000858_altered_metastatic_potential0.80102498
120MP0000049_abnormal_middle_ear0.79076032
121MP0005257_abnormal_intraocular_pressure0.77503428
122MP0005409_darkened_coat_color0.75660691
123MP0000762_abnormal_tongue_morphology0.74280268
124MP0002269_muscular_atrophy0.73581307
125MP0002234_abnormal_pharynx_morphology0.73516809
126MP0000733_abnormal_muscle_development0.72964633
127MP0002249_abnormal_larynx_morphology0.72906678
128MP0003941_abnormal_skin_development0.70890568
129MP0001216_abnormal_epidermal_layer0.68412634
130MP0002932_abnormal_joint_morphology0.67529928
131MP0004087_abnormal_muscle_fiber0.67340546
132MP0002233_abnormal_nose_morphology0.67275232
133MP0000467_abnormal_esophagus_morphology0.66712521
134MP0004859_abnormal_synaptic_plasticity0.66629400
135MP0005330_cardiomyopathy0.65826197
136MP0000750_abnormal_muscle_regeneration0.65188781
137MP0010630_abnormal_cardiac_muscle0.64662310
138MP0000747_muscle_weakness0.63996174
139MP0002060_abnormal_skin_morphology0.62603722
140MP0009931_abnormal_skin_appearance0.62181194
141MP0002163_abnormal_gland_morphology0.62082882
142MP0003755_abnormal_palate_morphology0.61937652
143MP0002970_abnormal_white_adipose0.61571720
144MP0002114_abnormal_axial_skeleton0.59659628
145MP0001873_stomach_inflammation0.58154502

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.41051644
2Medulloblastoma (HP:0002885)4.21930330
3Colon cancer (HP:0003003)4.11036275
4Breast hypoplasia (HP:0003187)3.91036816
5Abnormality of cells of the erythroid lineage (HP:0012130)3.52775105
6Selective tooth agenesis (HP:0001592)3.44535938
7Abnormal number of erythroid precursors (HP:0012131)3.20646626
8Ulnar bowing (HP:0003031)3.20532403
9Abnormality of the astrocytes (HP:0100707)3.08502111
10Astrocytoma (HP:0009592)3.08502111
11Achilles tendon contracture (HP:0001771)3.00193299
12Agnosia (HP:0010524)2.96451346
13Rhabdomyosarcoma (HP:0002859)2.95940309
14Broad distal phalanx of finger (HP:0009836)2.94653577
15Reticulocytopenia (HP:0001896)2.85534747
16Microvesicular hepatic steatosis (HP:0001414)2.83887503
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.81780247
18Ragged-red muscle fibers (HP:0003200)2.76597712
19Hyperacusis (HP:0010780)2.76188638
20Trismus (HP:0000211)2.74690140
21Neoplasm of striated muscle (HP:0009728)2.73582667
22Renal duplication (HP:0000075)2.73348250
23Cerebral hypomyelination (HP:0006808)2.71485315
24Impulsivity (HP:0100710)2.70958973
25Missing ribs (HP:0000921)2.68166112
26Distal lower limb amyotrophy (HP:0008944)2.66066195
27Neoplasm of the oral cavity (HP:0100649)2.63757595
28Insomnia (HP:0100785)2.62178886
29Aplastic anemia (HP:0001915)2.59818343
30Abnormality of the Achilles tendon (HP:0005109)2.59000364
31Rib fusion (HP:0000902)2.58864961
32Cholecystitis (HP:0001082)2.56603725
33Abnormal gallbladder physiology (HP:0012438)2.56603725
34Abnormality of the lower motor neuron (HP:0002366)2.55840667
35Aplasia/hypoplasia of the humerus (HP:0006507)2.55814705
36Overriding aorta (HP:0002623)2.55635289
37Short 4th metacarpal (HP:0010044)2.54159530
38Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.54159530
39Squamous cell carcinoma (HP:0002860)2.53837624
40Chromsome breakage (HP:0040012)2.53663021
41High pitched voice (HP:0001620)2.51396623
42Renovascular hypertension (HP:0100817)2.48407725
43Increased nuchal translucency (HP:0010880)2.46989583
44Supernumerary spleens (HP:0009799)2.46312014
45Basal cell carcinoma (HP:0002671)2.45214160
46Long palpebral fissure (HP:0000637)2.43051004
47Adenoma sebaceum (HP:0009720)2.42722573
48Angiofibromas (HP:0010615)2.42722573
49Glioma (HP:0009733)2.42116639
50Progressive muscle weakness (HP:0003323)2.40450857
51Esophageal atresia (HP:0002032)2.39889112
52Abnormality of the diencephalon (HP:0010662)2.39856531
53Bowel diverticulosis (HP:0005222)2.39588569
54Calcaneovalgus deformity (HP:0001848)2.38734529
55Multiple enchondromatosis (HP:0005701)2.38562680
56Oral leukoplakia (HP:0002745)2.33627230
57Macrocytic anemia (HP:0001972)2.33509063
58Abnormality of the calcaneus (HP:0008364)2.32336140
59Abnormality of reticulocytes (HP:0004312)2.32289476
60Absent thumb (HP:0009777)2.31585649
61Abnormality of the anterior horn cell (HP:0006802)2.31153843
62Degeneration of anterior horn cells (HP:0002398)2.31153843
63Absent radius (HP:0003974)2.30568145
64Centrally nucleated skeletal muscle fibers (HP:0003687)2.30400355
65Short humerus (HP:0005792)2.27700680
66Carpal bone hypoplasia (HP:0001498)2.26812984
67Abnormality of the labia minora (HP:0012880)2.25298399
68Pointed chin (HP:0000307)2.24387486
69Meckel diverticulum (HP:0002245)2.23199742
70Dysmetric saccades (HP:0000641)2.22676926
71Supernumerary bones of the axial skeleton (HP:0009144)2.21190695
72Abnormality of the umbilical cord (HP:0010881)2.20735992
73Chronic bronchitis (HP:0004469)2.17952177
74Down-sloping shoulders (HP:0200021)2.17315419
75Abnormal umbilical cord blood vessels (HP:0011403)2.17301887
76Single umbilical artery (HP:0001195)2.17301887
77Abnormality of the fetal cardiovascular system (HP:0010948)2.17301887
78Deformed tarsal bones (HP:0008119)2.17077221
79Aplasia involving forearm bones (HP:0009822)2.16968144
80Absent forearm bone (HP:0003953)2.16968144
81Abnormality of glycolysis (HP:0004366)2.16236664
82Deep palmar crease (HP:0006191)2.15099659
83Abnormality of the ileum (HP:0001549)2.14230239
84Abnormal lung lobation (HP:0002101)2.13241407
85Elfin facies (HP:0004428)2.11616882
86Birth length less than 3rd percentile (HP:0003561)2.11296628
87Patellar aplasia (HP:0006443)2.10962399
88Lower limb amyotrophy (HP:0007210)2.10511373
89Shawl scrotum (HP:0000049)2.09022389
90Myopathic facies (HP:0002058)2.08771904
91Reticulocytosis (HP:0001923)2.08435549
92Upper limb amyotrophy (HP:0009129)2.07399911
93Distal upper limb amyotrophy (HP:0007149)2.07399911
94Neoplasm of the pancreas (HP:0002894)2.07184956
95Abnormality of the salivary glands (HP:0010286)2.07029000
96Stridor (HP:0010307)2.05431945
97Progressive external ophthalmoplegia (HP:0000590)2.03823469
98Aplasia/Hypoplasia of the patella (HP:0006498)2.03035994
99Broad face (HP:0000283)2.02860379
100Patellar dislocation (HP:0002999)2.02190687
101Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.01669146
102Abdominal situs inversus (HP:0003363)2.01413431
103Abnormality of abdominal situs (HP:0011620)2.01413431
104Tracheoesophageal fistula (HP:0002575)2.00345333
105Atresia of the external auditory canal (HP:0000413)1.99294683
106Premature ovarian failure (HP:0008209)1.99225257
107Supernumerary ribs (HP:0005815)1.99216582
108Facial hemangioma (HP:0000329)1.98456979
109Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96987670
110Pseudobulbar signs (HP:0002200)1.96399446
111Turricephaly (HP:0000262)1.96168052
112Abnormality of the carotid arteries (HP:0005344)1.96086941
113Premature rupture of membranes (HP:0001788)1.95062499
114Disproportionate tall stature (HP:0001519)1.94477758
115Vertebral compression fractures (HP:0002953)1.93001287
116Proximal placement of thumb (HP:0009623)1.92662522
117Truncus arteriosus (HP:0001660)1.92563130
118Poikiloderma (HP:0001029)1.91186859
119Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90805830
12011 pairs of ribs (HP:0000878)1.89987196
121Spinal muscular atrophy (HP:0007269)1.88985238
122Hypoplasia of the radius (HP:0002984)1.87667168
123Duplication of thumb phalanx (HP:0009942)1.87298537
124High anterior hairline (HP:0009890)1.86260659
125Biliary tract neoplasm (HP:0100574)1.85946338
126Elbow flexion contracture (HP:0002987)1.84679298
127Testicular atrophy (HP:0000029)1.84503810
128Increased connective tissue (HP:0009025)1.83915789
129Abnormality of the 4th metacarpal (HP:0010012)1.83872037
130Abnormality of cochlea (HP:0000375)1.83626101
131Spastic diplegia (HP:0001264)1.83358546
132Difficulty climbing stairs (HP:0003551)1.82988613
133Neuroblastoma (HP:0003006)1.82980440
134Primitive neuroectodermal tumor (HP:0030065)1.82980440
135Neuroblastic tumors (HP:0004376)1.82980440
136Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.82980440
137Amaurosis fugax (HP:0100576)1.82177822
138Abnormal number of incisors (HP:0011064)1.81948090
139Deviation of the thumb (HP:0009603)1.81636816
140Premature skin wrinkling (HP:0100678)1.80384938
141Pallor (HP:0000980)1.80193204
142Shallow orbits (HP:0000586)1.77614956
143Flat cornea (HP:0007720)1.77595499
144Small intestinal stenosis (HP:0012848)1.77437278
145Duodenal stenosis (HP:0100867)1.77437278
146Urethral obstruction (HP:0000796)1.77429109
147Entropion (HP:0000621)1.75795963
148Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.74738519
149Absent epiphyses (HP:0010577)1.74738519
150Adducted thumb (HP:0001181)1.71972344
151Biconcave vertebral bodies (HP:0004586)1.69991810
152Rough bone trabeculation (HP:0100670)1.69224078
153Short nail (HP:0001799)1.67224728
154Thin ribs (HP:0000883)1.66074182
155Glossoptosis (HP:0000162)1.64992846
156Septate vagina (HP:0001153)1.64561415
157Abnormality of the tricuspid valve (HP:0001702)1.64314951
158Overlapping toe (HP:0001845)1.63535830
159Back pain (HP:0003418)1.62647071
160Natal tooth (HP:0000695)1.62095545
161Abnormality of the distal phalanges of the toes (HP:0010182)1.61531109
162Generalized amyotrophy (HP:0003700)1.61487669
163Ankyloglossia (HP:0010296)1.60193912
164Abnormality of the thoracic spine (HP:0100711)1.59023707
165Slender long bone (HP:0003100)1.57278956
166Microretrognathia (HP:0000308)1.56114185
167Hyperthyroidism (HP:0000836)1.55913771
168Bowed forearm bones (HP:0003956)1.55668846
169Bowing of the arm (HP:0006488)1.55668846
170Self-mutilation (HP:0000742)1.54103825
171Flared metaphyses (HP:0003015)1.53851862
172Distal lower limb muscle weakness (HP:0009053)1.51613190

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K105.56861960
2SMG14.07862326
3TLK13.45714150
4CDC72.99713054
5IRAK32.83568599
6BUB12.82168303
7WEE12.29239379
8PRPF4B2.24454981
9CDK1910.6417929
10EEF2K1.85731807
11TESK11.80542679
12NEK21.74652884
13SIK11.73751788
14PDK41.68808213
15PDK31.68808213
16ARAF1.67215172
17PASK1.47269561
18MAP2K31.47076722
19MST1R1.43150414
20TTK1.42097867
21VRK21.41671772
22PLK41.36859188
23NEK11.33735522
24TESK21.32570027
25CDK41.26093912
26PIM21.24249897
27CDK71.22402721
28STK41.20911350
29ICK1.19762014
30EPHA21.18146740
31DYRK31.17435099
32ERN11.16856942
33TSSK61.16096845
34CDK121.16011062
35PLK11.11463370
36PRKD31.10819262
37EPHB21.09242590
38PAK41.08473591
39SRPK11.07648029
40ACVR1B1.06623056
41TAOK21.02584259
42CDK81.01862881
43MAPK111.00055845
44LATS20.98535643
45SCYL20.97710392
46RPS6KB20.97537802
47CHEK20.96673385
48AURKA0.96628361
49MAP3K80.95882115
50EIF2AK10.94553503
51BRSK20.94211134
52KDR0.93895526
53PKN20.92561298
54FGFR40.89033367
55PDGFRA0.88205942
56CDK11A0.87849672
57PBK0.87100023
58PDK20.86875717
59TRIB30.86775212
60ATR0.81850117
61PLK30.78431417
62KSR20.77327246
63STK100.77130463
64AURKB0.75357807
65CHEK10.75218266
66MAP3K90.74995178
67MAP3K130.73998880
68BRSK10.71155161
69MAP2K60.70855073
70ALK0.66333118
71CAMK1D0.66102272
72SIK20.63912533
73CDK20.63590562
74PTK20.62524840
75TGFBR10.62052554
76IRAK20.61082184
77LMTK20.60925105
78NME10.59264361
79DAPK10.58690233
80MTOR0.58670304
81PNCK0.57969880
82LRRK20.56969201
83MAPKAPK30.56270529
84RAF10.54547961
85MKNK10.53804526
86PAK10.53408832
87PRKD20.50712173
88RIPK10.50710067
89ATM0.50331337
90RPS6KA20.50073872
91PDPK10.49113333
92TTN0.48652798
93CDK90.46673434
94NTRK10.46008078
95TAF10.45527717
96PTK60.45282170
97RPS6KA40.44939112
98RPS6KL10.44055329
99RPS6KC10.44055329
100MKNK20.43774242
101VRK10.43219802
102CSNK1E0.39698935
103NME20.38942952
104PRKCI0.37327862
105MET0.37213633
106RPS6KA50.36925924
107ILK0.36919867
108PAK20.35136291
109CDK10.34608517
110CSNK2A20.34491715
111RPS6KA10.34384878
112BCKDK0.34365901
113CDK60.33871344
114AKT20.33139383
115PIM10.32502174
116CDK150.30593354
117MAP3K110.28870143
118IRAK10.28804274
119TYRO30.28374442
120DDR20.28340100
121CDK180.27802609
122PRKDC0.27581821
123DAPK30.26959027
124CDK140.25851895
125CSNK2A10.24617764
126MAPK90.23628268
127KSR10.21750698
128LIMK10.21657670
129FLT30.21003469
130FGFR10.19654654
131EIF2AK30.19134408
132BMX0.19110405
133BRAF0.17408747
134PHKG10.17365873
135PHKG20.17365873
136TAOK10.15991460
137CSNK1D0.15224943
138MAPK120.14422028
139MAP2K20.13513925

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.15049625
2Mismatch repair_Homo sapiens_hsa034304.56243585
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.70202768
4RNA transport_Homo sapiens_hsa030133.66916218
5Ribosome_Homo sapiens_hsa030103.60402126
6Spliceosome_Homo sapiens_hsa030403.36929285
7Base excision repair_Homo sapiens_hsa034102.96964310
8One carbon pool by folate_Homo sapiens_hsa006702.66853223
9Cell cycle_Homo sapiens_hsa041102.57831574
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.51386127
11Homologous recombination_Homo sapiens_hsa034402.47100836
12Nucleotide excision repair_Homo sapiens_hsa034202.40131080
13Proteasome_Homo sapiens_hsa030502.32304112
14RNA polymerase_Homo sapiens_hsa030202.30747851
15Pyrimidine metabolism_Homo sapiens_hsa002402.21715227
16mRNA surveillance pathway_Homo sapiens_hsa030152.05389310
17Systemic lupus erythematosus_Homo sapiens_hsa053221.99755363
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.90376473
19Fanconi anemia pathway_Homo sapiens_hsa034601.71540326
20Sulfur relay system_Homo sapiens_hsa041221.65906529
21RNA degradation_Homo sapiens_hsa030181.63564325
22Biosynthesis of amino acids_Homo sapiens_hsa012301.51919887
23Oocyte meiosis_Homo sapiens_hsa041141.51656817
24p53 signaling pathway_Homo sapiens_hsa041151.34940117
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33575716
26Basal transcription factors_Homo sapiens_hsa030221.32025492
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.30061141
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27586892
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.23649411
30Non-homologous end-joining_Homo sapiens_hsa034501.21878222
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.21451256
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17192523
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13250869
34Selenocompound metabolism_Homo sapiens_hsa004501.11760600
35Purine metabolism_Homo sapiens_hsa002301.08637413
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07103347
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05283311
38Alcoholism_Homo sapiens_hsa050341.02707221
39Viral carcinogenesis_Homo sapiens_hsa052030.96700099
40Basal cell carcinoma_Homo sapiens_hsa052170.94715102
41Prion diseases_Homo sapiens_hsa050200.94576523
42Arginine biosynthesis_Homo sapiens_hsa002200.92818212
43N-Glycan biosynthesis_Homo sapiens_hsa005100.91446183
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91117957
45Carbon metabolism_Homo sapiens_hsa012000.91094562
46Other glycan degradation_Homo sapiens_hsa005110.90997952
47Vitamin B6 metabolism_Homo sapiens_hsa007500.90429694
48Epstein-Barr virus infection_Homo sapiens_hsa051690.89599970
49Pentose phosphate pathway_Homo sapiens_hsa000300.84069073
50Mineral absorption_Homo sapiens_hsa049780.83941577
51Glioma_Homo sapiens_hsa052140.83025411
52Pancreatic cancer_Homo sapiens_hsa052120.82575139
53Acute myeloid leukemia_Homo sapiens_hsa052210.80958330
54Hedgehog signaling pathway_Homo sapiens_hsa043400.79437880
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.77621147
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76432485
57HTLV-I infection_Homo sapiens_hsa051660.76401645
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75443330
59Hippo signaling pathway_Homo sapiens_hsa043900.73672867
60MicroRNAs in cancer_Homo sapiens_hsa052060.72859476
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67909327
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66661829
63Endometrial cancer_Homo sapiens_hsa052130.63968998
64Bladder cancer_Homo sapiens_hsa052190.63626532
65Fructose and mannose metabolism_Homo sapiens_hsa000510.59756142
66Insulin signaling pathway_Homo sapiens_hsa049100.59375038
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58503028
68Pyruvate metabolism_Homo sapiens_hsa006200.58125617
69Apoptosis_Homo sapiens_hsa042100.57869037
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56853130
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.56560836
72Thyroid cancer_Homo sapiens_hsa052160.56475183
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54976203
74ErbB signaling pathway_Homo sapiens_hsa040120.51430581
75Glucagon signaling pathway_Homo sapiens_hsa049220.50976661
76Glutathione metabolism_Homo sapiens_hsa004800.50116750
77Antigen processing and presentation_Homo sapiens_hsa046120.47589836
78Tight junction_Homo sapiens_hsa045300.46687028
79B cell receptor signaling pathway_Homo sapiens_hsa046620.45877315
80Notch signaling pathway_Homo sapiens_hsa043300.45638044
81beta-Alanine metabolism_Homo sapiens_hsa004100.44000070
82Vibrio cholerae infection_Homo sapiens_hsa051100.42186877
83Prostate cancer_Homo sapiens_hsa052150.41803818
84Hepatitis B_Homo sapiens_hsa051610.39641450
85Folate biosynthesis_Homo sapiens_hsa007900.39041778
86Herpes simplex infection_Homo sapiens_hsa051680.38640273
87Phenylalanine metabolism_Homo sapiens_hsa003600.38407079
88Huntingtons disease_Homo sapiens_hsa050160.38270099
89Small cell lung cancer_Homo sapiens_hsa052220.37644890
90VEGF signaling pathway_Homo sapiens_hsa043700.37180483
91Wnt signaling pathway_Homo sapiens_hsa043100.34456427
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32933610
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32828541
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32771342
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31292483
96Lysine degradation_Homo sapiens_hsa003100.31227792
97HIF-1 signaling pathway_Homo sapiens_hsa040660.30279519
98Melanoma_Homo sapiens_hsa052180.28638576
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28232578
100Arginine and proline metabolism_Homo sapiens_hsa003300.27823078
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27491977
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26368998
103Linoleic acid metabolism_Homo sapiens_hsa005910.26177961
104Colorectal cancer_Homo sapiens_hsa052100.24996074
105Renal cell carcinoma_Homo sapiens_hsa052110.24614908
106TGF-beta signaling pathway_Homo sapiens_hsa043500.24536434
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.23819179
108Legionellosis_Homo sapiens_hsa051340.22028449
109Cardiac muscle contraction_Homo sapiens_hsa042600.21800026
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21430127
111Adherens junction_Homo sapiens_hsa045200.20647471
112Fat digestion and absorption_Homo sapiens_hsa049750.20565580
113mTOR signaling pathway_Homo sapiens_hsa041500.19957495
114Shigellosis_Homo sapiens_hsa051310.19886892
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19046859
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18795923
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18621506
118Pathways in cancer_Homo sapiens_hsa052000.16939928
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.16283965
120Chronic myeloid leukemia_Homo sapiens_hsa052200.14734694
121Proteoglycans in cancer_Homo sapiens_hsa052050.13758773
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13659817
123AMPK signaling pathway_Homo sapiens_hsa041520.13473784
124Fatty acid biosynthesis_Homo sapiens_hsa000610.12961743
125Galactose metabolism_Homo sapiens_hsa000520.09795215
126Non-small cell lung cancer_Homo sapiens_hsa052230.07333422

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