THPO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.82922819
2L-phenylalanine catabolic process (GO:0006559)6.82922819
3L-phenylalanine metabolic process (GO:0006558)6.49617656
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.49617656
5very-low-density lipoprotein particle assembly (GO:0034379)6.27283771
6aromatic amino acid family catabolic process (GO:0009074)6.18253645
7indole-containing compound catabolic process (GO:0042436)5.71121495
8indolalkylamine catabolic process (GO:0046218)5.71121495
9tryptophan catabolic process (GO:0006569)5.71121495
10regulation of plasminogen activation (GO:0010755)5.58934852
11tryptophan metabolic process (GO:0006568)5.55878234
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.49221112
13protein-lipid complex assembly (GO:0065005)5.48282604
14intestinal cholesterol absorption (GO:0030299)5.46013353
15kynurenine metabolic process (GO:0070189)5.40265375
16bile acid biosynthetic process (GO:0006699)5.29964197
17glyoxylate metabolic process (GO:0046487)5.13917683
18plasma lipoprotein particle organization (GO:0071827)5.04468797
19high-density lipoprotein particle remodeling (GO:0034375)4.97354780
20negative regulation of fibrinolysis (GO:0051918)4.79115350
21urea cycle (GO:0000050)4.74296610
22urea metabolic process (GO:0019627)4.74296610
23sulfur amino acid catabolic process (GO:0000098)4.74233265
24protein-lipid complex subunit organization (GO:0071825)4.73921455
25regulation of fibrinolysis (GO:0051917)4.72118673
26regulation of protein activation cascade (GO:2000257)4.69866664
27protein carboxylation (GO:0018214)4.59974687
28peptidyl-glutamic acid carboxylation (GO:0017187)4.59974687
29aromatic amino acid family metabolic process (GO:0009072)4.56276613
30serine family amino acid catabolic process (GO:0009071)4.53026485
31alpha-linolenic acid metabolic process (GO:0036109)4.52305244
32cysteine metabolic process (GO:0006534)4.50242855
33bile acid metabolic process (GO:0008206)4.49760254
34complement activation, alternative pathway (GO:0006957)4.48611521
35positive regulation of triglyceride lipase activity (GO:0061365)4.47339741
36positive regulation of lipoprotein lipase activity (GO:0051006)4.47339741
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.47163533
38positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.40194860
39alpha-amino acid catabolic process (GO:1901606)4.38995725
40regulation of apoptotic cell clearance (GO:2000425)4.37891173
41glutamate metabolic process (GO:0006536)4.36427405
42proline metabolic process (GO:0006560)4.34572768
43lysine catabolic process (GO:0006554)4.34120581
44lysine metabolic process (GO:0006553)4.34120581
45cellular ketone body metabolic process (GO:0046950)4.33964885
46coenzyme catabolic process (GO:0009109)4.33912627
47regulation of complement activation (GO:0030449)4.33701148
48reverse cholesterol transport (GO:0043691)4.32638074
49nitrogen cycle metabolic process (GO:0071941)4.31834600
50tyrosine metabolic process (GO:0006570)4.27255141
51acute-phase response (GO:0006953)4.26583259
52regulation of cholesterol esterification (GO:0010872)4.26281659
53epoxygenase P450 pathway (GO:0019373)4.21979595
54indolalkylamine metabolic process (GO:0006586)4.19205895
55homocysteine metabolic process (GO:0050667)4.15813377
56acylglycerol homeostasis (GO:0055090)4.14527169
57triglyceride homeostasis (GO:0070328)4.14527169
58dicarboxylic acid biosynthetic process (GO:0043650)4.11350382
59protein-lipid complex remodeling (GO:0034368)4.10751444
60macromolecular complex remodeling (GO:0034367)4.10751444
61plasma lipoprotein particle remodeling (GO:0034369)4.10751444
62regulation of triglyceride catabolic process (GO:0010896)4.06860319
63negative regulation of blood coagulation (GO:0030195)4.05691179
64negative regulation of hemostasis (GO:1900047)4.05691179
65imidazole-containing compound metabolic process (GO:0052803)4.05295202
66cellular amino acid catabolic process (GO:0009063)4.03457492
67phospholipid efflux (GO:0033700)3.94779978
68amine catabolic process (GO:0009310)3.91638842
69cellular biogenic amine catabolic process (GO:0042402)3.91638842
70amino-acid betaine metabolic process (GO:0006577)3.85916279
71regulation of bile acid biosynthetic process (GO:0070857)3.78531638
72negative regulation of cholesterol transport (GO:0032375)3.78206211
73negative regulation of sterol transport (GO:0032372)3.78206211
74arginine metabolic process (GO:0006525)3.77841191
75cellular modified amino acid catabolic process (GO:0042219)3.77073405
76omega-hydroxylase P450 pathway (GO:0097267)3.73128877
77ketone body metabolic process (GO:1902224)3.71939902
78cholesterol efflux (GO:0033344)3.71453229
79drug catabolic process (GO:0042737)3.70661635
80peptidyl-glutamic acid modification (GO:0018200)3.68795434
81regulation of humoral immune response (GO:0002920)3.66534898
82lipoprotein metabolic process (GO:0042157)3.66289922
83negative regulation of coagulation (GO:0050819)3.65719488
84indole-containing compound metabolic process (GO:0042430)3.62867633
85negative regulation of protein activation cascade (GO:2000258)3.62312366
86bile acid and bile salt transport (GO:0015721)3.61258134
87cholesterol homeostasis (GO:0042632)3.57479481
88negative regulation of wound healing (GO:0061045)3.57407982
89cofactor catabolic process (GO:0051187)3.55898685
90aldehyde catabolic process (GO:0046185)3.54232285
91sterol homeostasis (GO:0055092)3.52976569
92benzene-containing compound metabolic process (GO:0042537)3.51198771
93plasma lipoprotein particle clearance (GO:0034381)3.51182366
94aspartate family amino acid catabolic process (GO:0009068)3.50277133
95opsonization (GO:0008228)3.50118811
96positive regulation of fatty acid biosynthetic process (GO:0045723)3.48391552
97serine family amino acid metabolic process (GO:0009069)3.48106307
98glycine metabolic process (GO:0006544)3.46452972
99cholesterol transport (GO:0030301)3.46388269
100sterol transport (GO:0015918)3.46388269
101NAD biosynthetic process (GO:0009435)3.44447688
102organic acid catabolic process (GO:0016054)3.43445004
103carboxylic acid catabolic process (GO:0046395)3.43445004
104positive regulation of blood coagulation (GO:0030194)3.42919276
105positive regulation of hemostasis (GO:1900048)3.42919276
106negative regulation of lipase activity (GO:0060192)3.41178444
107exogenous drug catabolic process (GO:0042738)3.39580609
108cellular glucuronidation (GO:0052695)3.38943505
109heme transport (GO:0015886)3.35907843
110ethanol metabolic process (GO:0006067)3.33520060
111acetyl-CoA metabolic process (GO:0006084)3.31493507
112regulation of lipoprotein particle clearance (GO:0010984)3.31104148
113fibrinolysis (GO:0042730)3.27637875
114regulation of cholesterol biosynthetic process (GO:0045540)3.27251298
115complement activation, classical pathway (GO:0006958)3.26146025
116dicarboxylic acid catabolic process (GO:0043649)3.24875663
117serine family amino acid biosynthetic process (GO:0009070)3.23734500
118cytolysis (GO:0019835)3.22563295
119plasma lipoprotein particle assembly (GO:0034377)3.22090320
120intestinal absorption (GO:0050892)3.21973233
121short-chain fatty acid metabolic process (GO:0046459)3.20977722
1222-oxoglutarate metabolic process (GO:0006103)3.19947251
123glucuronate metabolic process (GO:0019585)3.19853348
124uronic acid metabolic process (GO:0006063)3.19853348
125neurotransmitter-gated ion channel clustering (GO:0072578)3.19045115
126blood coagulation, intrinsic pathway (GO:0007597)3.18578038
127low-density lipoprotein particle remodeling (GO:0034374)3.16726993
128acute inflammatory response (GO:0002526)3.16334968
129ethanol oxidation (GO:0006069)3.16158019
130pyridine nucleotide biosynthetic process (GO:0019363)3.15895766
131nicotinamide nucleotide biosynthetic process (GO:0019359)3.15895766
132complement activation (GO:0006956)3.13811353
133protein activation cascade (GO:0072376)3.13397054
134diacylglycerol metabolic process (GO:0046339)3.10006431
135positive regulation of coagulation (GO:0050820)3.09889651
136NAD metabolic process (GO:0019674)3.09846144
137drug metabolic process (GO:0017144)3.09786996
138positive regulation of steroid metabolic process (GO:0045940)3.09612451
139oxidative demethylation (GO:0070989)3.09578283
140glutamine family amino acid biosynthetic process (GO:0009084)3.09330501
141L-serine metabolic process (GO:0006563)3.08502042
142oxaloacetate metabolic process (GO:0006107)3.06737430

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.32240467
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.75417450
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.87293323
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.74639985
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.51374793
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.39413392
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.44083612
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.29138746
9GBX2_23144817_ChIP-Seq_PC3_Human3.13724951
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.69806028
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.49573073
12EZH2_22144423_ChIP-Seq_EOC_Human2.48059478
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.37966271
14LXR_22292898_ChIP-Seq_THP-1_Human2.02534423
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01527597
16TAF15_26573619_Chip-Seq_HEK293_Human1.86363681
17CTCF_27219007_Chip-Seq_Bcells_Human1.74290903
18DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.71091063
19* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63717208
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56484825
21* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55331732
22P68_20966046_ChIP-Seq_HELA_Human1.54677917
23* RARA_24833708_ChIP-Seq_LIVER_Mouse1.54333991
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.53541584
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51767341
26HTT_18923047_ChIP-ChIP_STHdh_Human1.51413446
27* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.50431202
28* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50250907
29SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.48485766
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48140070
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47422899
32SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.46193507
33* RARB_24833708_ChIP-Seq_LIVER_Mouse1.45590165
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41856373
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41550397
36ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36548688
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33380110
38* XRN2_22483619_ChIP-Seq_HELA_Human1.32241840
39CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32206421
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.30983264
41REST_21632747_ChIP-Seq_MESCs_Mouse1.30850437
42* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30415827
43* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.30273145
44SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.27283072
45E2F1_20622854_ChIP-Seq_HELA_Human1.26428083
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25752711
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25682531
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.25519000
49* EED_16625203_ChIP-ChIP_MESCs_Mouse1.24243641
50P300_19829295_ChIP-Seq_ESCs_Human1.24012041
51* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23825272
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23598071
53* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23155053
54SMAD4_21799915_ChIP-Seq_A2780_Human1.21401603
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.20574241
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20458216
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20291042
58* FOXA2_19822575_ChIP-Seq_HepG2_Human1.19550248
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.18226939
60MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.16125008
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.15697072
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15231127
63* FOXP1_21924763_ChIP-Seq_HESCs_Human1.14385086
64* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12897444
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12272888
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.12249275
67PHF8_20622854_ChIP-Seq_HELA_Human1.11569223
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11539723
69RACK7_27058665_Chip-Seq_MCF-7_Human1.10812428
70JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10781358
71CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10743627
72YY1_22570637_ChIP-Seq_MALME-3M_Human1.10673598
73AR_21909140_ChIP-Seq_LNCAP_Human1.09831467
74SMC4_20622854_ChIP-Seq_HELA_Human1.09146783
75HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08196783
76* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08029366
77* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08029366
78HNF4A_19822575_ChIP-Seq_HepG2_Human1.05268431
79DROSHA_22980978_ChIP-Seq_HELA_Human1.04752308
80* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04440862
81ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03694307
82JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02498483
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02127534
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02127534
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99911208
86EZH2_27294783_Chip-Seq_ESCs_Mouse0.99667329
87ETS1_21867929_ChIP-Seq_TH2_Mouse0.99247468
88MYC_18358816_ChIP-ChIP_MESCs_Mouse0.99007808
89SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98473064
90VDR_22108803_ChIP-Seq_LS180_Human0.97757805
91* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.96645687
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96027563
93SOX2_21211035_ChIP-Seq_LN229_Human0.95767620
94SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95699535
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94811525
96RARB_27405468_Chip-Seq_BRAIN_Mouse0.94764129
97POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94300665
98BCOR_27268052_Chip-Seq_Bcells_Human0.93746048
99SA1_27219007_Chip-Seq_Bcells_Human0.93383752
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92111142
101NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90197717
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90121678
103ZNF263_19887448_ChIP-Seq_K562_Human0.89937079
104ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89704779
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89246135
106PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89132567
107ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89086350
108CTCF_21964334_Chip-Seq_Bcells_Human0.88960098
109SOX2_21211035_ChIP-Seq_LN229_Gbm0.88623150
110SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88372319
111SA1_27219007_Chip-Seq_ERYTHROID_Human0.87917144
112EZH2_27304074_Chip-Seq_ESCs_Mouse0.87686374
113BCL6_27268052_Chip-Seq_Bcells_Human0.87372880
114AR_25329375_ChIP-Seq_VCAP_Human0.87227858
115SMAD3_21741376_ChIP-Seq_EPCs_Human0.87005603
116* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86576376
117SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85896425
118KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84891531
119ERA_21632823_ChIP-Seq_H3396_Human0.84745667
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.84568504
121AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84243804
122STAT3_23295773_ChIP-Seq_U87_Human0.83897617
123* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.83623157
124RBPJ_22232070_ChIP-Seq_NCS_Mouse0.83605726
125AHR_22903824_ChIP-Seq_MCF-7_Human0.82832881
126CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81926755
127JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.81393572
128ELF1_20517297_ChIP-Seq_JURKAT_Human0.81188577
129UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.81005839
130TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79339174
131SOX3_22085726_ChIP-Seq_NPCs_Mouse0.78155236
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77964876
133BCAT_22108803_ChIP-Seq_LS180_Human0.77824064
134SPI1_26923725_Chip-Seq_HPCs_Mouse0.77637355
135TOP2B_26459242_ChIP-Seq_MCF-7_Human0.77153355
136CREB1_26743006_Chip-Seq_LNCaP_Human0.77015385
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.76284174
138CTCF_20526341_ChIP-Seq_ESCs_Human0.76162404
139FUS_26573619_Chip-Seq_HEK293_Human0.76109163
140ESR2_21235772_ChIP-Seq_MCF-7_Human0.75606088
141DNAJC2_21179169_ChIP-ChIP_NT2_Human0.75493876
142GABP_19822575_ChIP-Seq_HepG2_Human0.75407101
143BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74849804
144* P53_21459846_ChIP-Seq_SAOS-2_Human0.74727852
145SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.74535009
146OCT4_18692474_ChIP-Seq_MEFs_Mouse0.74228505
147RXRA_24833708_ChIP-Seq_LIVER_Mouse0.74176195
148RAC3_21632823_ChIP-Seq_H3396_Human0.74025761
149GATA3_21867929_ChIP-Seq_CD8_Mouse0.73962309
150UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.73560861
151THAP11_20581084_ChIP-Seq_MESCs_Mouse0.73203041
152PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.73088842
153PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.72713839
154CLOCK_20551151_ChIP-Seq_293T_Human0.72580052
155GATA1_22025678_ChIP-Seq_K562_Human0.71367054
156AR_21572438_ChIP-Seq_LNCaP_Human0.71059661
157RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.70885311
158SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.70399992
159TCF4_23295773_ChIP-Seq_U87_Human0.70253925
160SMAD4_21741376_ChIP-Seq_EPCs_Human0.70176345
161ZNF217_24962896_ChIP-Seq_MCF-7_Human0.69918270
162* MYC_19915707_ChIP-ChIP_AK7_Human0.68947353
163KDM2B_26808549_Chip-Seq_REH_Human0.68727805
164PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.68486207
165SMAD4_21741376_ChIP-Seq_HESCs_Human0.67574819
166ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.66169224
167TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.66130536
168RUNX2_22187159_ChIP-Seq_PCA_Human0.65454885
169JUN_21703547_ChIP-Seq_K562_Human0.65419270
170POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.64959962
171TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.64959962

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.15151861
2MP0005360_urolithiasis6.63567945
3MP0005085_abnormal_gallbladder_physiolo5.80625735
4MP0005365_abnormal_bile_salt5.48999039
5MP0008875_abnormal_xenobiotic_pharmacok4.69304967
6MP0003806_abnormal_nucleotide_metabolis3.84673110
7MP0010329_abnormal_lipoprotein_level3.42127463
8MP0003252_abnormal_bile_duct3.20117170
9MP0003195_calcinosis2.79711359
10MP0003122_maternal_imprinting2.60439647
11MP0005332_abnormal_amino_acid2.59047827
12MP0002822_catalepsy2.32294513
13MP0002876_abnormal_thyroid_physiology2.30147848
14MP0005083_abnormal_biliary_tract2.30145373
15MP0001666_abnormal_nutrient_absorption2.12141099
16MP0009840_abnormal_foam_cell2.09676052
17MP0004019_abnormal_vitamin_homeostasis2.08502900
18MP0002118_abnormal_lipid_homeostasis1.87189469
19MP0003880_abnormal_central_pattern1.86988983
20MP0004859_abnormal_synaptic_plasticity1.86272363
21MP0003191_abnormal_cellular_cholesterol1.78037369
22MP0001661_extended_life_span1.69412288
23MP0003123_paternal_imprinting1.67421211
24MP0000609_abnormal_liver_physiology1.60537961
25MP0009697_abnormal_copulation1.58620849
26MP0005319_abnormal_enzyme/_coenzyme1.52768262
27MP0000566_synostosis1.50432223
28MP0002138_abnormal_hepatobiliary_system1.48000073
29MP0001986_abnormal_taste_sensitivity1.47652900
30MP0009745_abnormal_behavioral_response1.45009295
31MP0005408_hypopigmentation1.44980713
32MP0003868_abnormal_feces_composition1.42743628
33MP0005584_abnormal_enzyme/coenzyme_acti1.42075341
34MP0001764_abnormal_homeostasis1.40540307
35MP0003635_abnormal_synaptic_transmissio1.31484826
36MP0009780_abnormal_chondrocyte_physiolo1.30543867
37MP0002249_abnormal_larynx_morphology1.29562575
38MP0005423_abnormal_somatic_nervous1.27106916
39MP0002064_seizures1.22618837
40MP0002063_abnormal_learning/memory/cond1.21622427
41MP0002089_abnormal_postnatal_growth/wei1.20573220
42MP0002837_dystrophic_cardiac_calcinosis1.19321715
43MP0002736_abnormal_nociception_after1.18197978
44MP0005647_abnormal_sex_gland1.16297477
45MP0003879_abnormal_hair_cell1.13895746
46MP0005646_abnormal_pituitary_gland1.11956923
47MP0003329_amyloid_beta_deposits1.10408466
48MP0001968_abnormal_touch/_nociception1.10355082
49MP0003136_yellow_coat_color1.09649428
50MP0004043_abnormal_pH_regulation1.09411575
51MP0005451_abnormal_body_composition1.09018513
52MP0006292_abnormal_olfactory_placode1.08923538
53MP0005636_abnormal_mineral_homeostasis1.07678686
54MP0000604_amyloidosis1.07087971
55MP0010030_abnormal_orbit_morphology1.06193467
56MP0002572_abnormal_emotion/affect_behav1.05650577
57MP0001915_intracranial_hemorrhage1.03563776
58MP0009046_muscle_twitch1.01187170
59MP0003172_abnormal_lysosome_physiology0.98892702
60MP0004270_analgesia0.98507455
61MP0003567_abnormal_fetal_cardiomyocyte0.98106314
62MP0003890_abnormal_embryonic-extraembry0.97400228
63MP0002272_abnormal_nervous_system0.96151230
64MP0002078_abnormal_glucose_homeostasis0.96111121
65MP0002132_abnormal_respiratory_system0.95084268
66MP0003011_delayed_dark_adaptation0.93159654
67MP0005535_abnormal_body_temperature0.92347499
68MP0001501_abnormal_sleep_pattern0.90264585
69MP0009643_abnormal_urine_homeostasis0.89948993
70MP0003941_abnormal_skin_development0.89424402
71MP0002282_abnormal_trachea_morphology0.85921057
72MP0002735_abnormal_chemical_nociception0.83850167
73MP0006276_abnormal_autonomic_nervous0.83546291
74MP0001440_abnormal_grooming_behavior0.80393770
75MP0001756_abnormal_urination0.79186503
76MP0005084_abnormal_gallbladder_morpholo0.77786018
77MP0002254_reproductive_system_inflammat0.77649988
78MP0003656_abnormal_erythrocyte_physiolo0.77502246
79MP0003121_genomic_imprinting0.77350262
80MP0003878_abnormal_ear_physiology0.76949690
81MP0005377_hearing/vestibular/ear_phenot0.76949690
82MP0005058_abnormal_lysosome_morphology0.76699473
83MP0008874_decreased_physiological_sensi0.75822456
84MP0006036_abnormal_mitochondrial_physio0.75530892
85MP0005409_darkened_coat_color0.75505929
86MP0004133_heterotaxia0.75063220
87MP0000003_abnormal_adipose_tissue0.74954245
88MP0004130_abnormal_muscle_cell0.74767689
89MP0005376_homeostasis/metabolism_phenot0.74240420
90MP0009642_abnormal_blood_homeostasis0.74202319
91MP0009053_abnormal_anal_canal0.74114481
92MP0003186_abnormal_redox_activity0.74094338
93MP0010368_abnormal_lymphatic_system0.73958135
94MP0000598_abnormal_liver_morphology0.73693625
95MP0000751_myopathy0.73155272
96MP0005266_abnormal_metabolism0.73071637
97MP0005448_abnormal_energy_balance0.73066658
98MP0001188_hyperpigmentation0.71899266
99MP0002067_abnormal_sensory_capabilities0.71521727
100MP0004142_abnormal_muscle_tone0.71504211
101MP0008872_abnormal_physiological_respon0.69367179
102MP0005551_abnormal_eye_electrophysiolog0.68444572
103MP0000013_abnormal_adipose_tissue0.68317186
104MP0001293_anophthalmia0.67975313
105MP0001486_abnormal_startle_reflex0.67351574
106MP0001984_abnormal_olfaction0.67196238
107MP0005257_abnormal_intraocular_pressure0.67182075
108MP0003638_abnormal_response/metabolism_0.67122822
109MP0001765_abnormal_ion_homeostasis0.66959724
110MP0003633_abnormal_nervous_system0.66482352
111MP0005670_abnormal_white_adipose0.66263727
112MP0002069_abnormal_eating/drinking_beha0.65917827
113MP0006035_abnormal_mitochondrial_morpho0.65841104
114MP0009384_cardiac_valve_regurgitation0.65336772
115MP0005330_cardiomyopathy0.65164160
116MP0009672_abnormal_birth_weight0.64236809
117MP0001324_abnormal_eye_pigmentation0.63536678
118MP0003718_maternal_effect0.63312990
119MP0003953_abnormal_hormone_level0.63169051
120MP0005167_abnormal_blood-brain_barrier0.61866173
121MP0002971_abnormal_brown_adipose0.60856286
122MP0002909_abnormal_adrenal_gland0.59915221
123MP0003690_abnormal_glial_cell0.59826034
124MP0002734_abnormal_mechanical_nocicepti0.59435607
125MP0009764_decreased_sensitivity_to0.59277548
126MP0005595_abnormal_vascular_smooth0.56706138
127MP0000639_abnormal_adrenal_gland0.55972556
128MP0002697_abnormal_eye_size0.55471901
129MP0003119_abnormal_digestive_system0.55363984
130MP0003787_abnormal_imprinting0.55026184
131MP0003631_nervous_system_phenotype0.54916796
132MP0005334_abnormal_fat_pad0.54407001
133MP0002160_abnormal_reproductive_system0.54159032
134MP0005410_abnormal_fertilization0.53346468
135MP0002733_abnormal_thermal_nociception0.52475983
136MP0004272_abnormal_basement_membrane0.51210166
137MP0005076_abnormal_cell_differentiation0.49784182
138MP0009763_increased_sensitivity_to0.48636762
139MP0002092_abnormal_eye_morphology0.48570239
140MP0002938_white_spotting0.48072051
141MP0003115_abnormal_respiratory_system0.47788253
142MP0005395_other_phenotype0.47142743
143MP0003183_abnormal_peptide_metabolism0.47019836
144MP0002557_abnormal_social/conspecific_i0.44920240
145MP0009765_abnormal_xenobiotic_induced0.44537334
146MP0005220_abnormal_exocrine_pancreas0.44452476
147MP0005499_abnormal_olfactory_system0.44222619
148MP0005394_taste/olfaction_phenotype0.44222619
149MP0003075_altered_response_to0.44114947
150MP0003315_abnormal_perineum_morphology0.43916091
151MP0003942_abnormal_urinary_system0.43790394
152MP0002928_abnormal_bile_duct0.43374539
153MP0004858_abnormal_nervous_system0.42422614
154MP0003632_abnormal_nervous_system0.41536736
155MP0001730_embryonic_growth_arrest0.39044873

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.41942958
2Intrahepatic cholestasis (HP:0001406)6.12712031
3Deep venous thrombosis (HP:0002625)6.00790725
4Prolonged partial thromboplastin time (HP:0003645)5.76232729
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.56312246
6Hypobetalipoproteinemia (HP:0003563)5.49408091
7Xanthomatosis (HP:0000991)4.99697166
8Hyperlipoproteinemia (HP:0010980)4.69727680
9Complement deficiency (HP:0004431)4.44390086
10Hemorrhage of the eye (HP:0011885)4.15030317
11Joint hemorrhage (HP:0005261)3.97973478
12Hypolipoproteinemia (HP:0010981)3.97809392
13Hyperglycinemia (HP:0002154)3.97312973
14Hyperammonemia (HP:0001987)3.92713570
15Conjugated hyperbilirubinemia (HP:0002908)3.91658120
16Ketosis (HP:0001946)3.87618173
17Glomerulonephritis (HP:0000099)3.87568007
18Abnormality of the common coagulation pathway (HP:0010990)3.87450923
19Hyperglycinuria (HP:0003108)3.75702689
20Hyperventilation (HP:0002883)3.75332350
21Abnormality of methionine metabolism (HP:0010901)3.74849859
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.72861128
23Focal motor seizures (HP:0011153)3.71680765
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.63523482
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.62063883
26Epidermoid cyst (HP:0200040)3.58848993
27Abnormality of glycine metabolism (HP:0010895)3.54285752
28Abnormality of serine family amino acid metabolism (HP:0010894)3.54285752
29Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.50847850
30Fat malabsorption (HP:0002630)3.42822903
31Hypoalphalipoproteinemia (HP:0003233)3.42323054
32Vaginal fistula (HP:0004320)3.37499028
33Abnormality of the intrinsic pathway (HP:0010989)3.36111479
34Gout (HP:0001997)3.07116574
35Abnormality of complement system (HP:0005339)3.06090590
36* Spontaneous abortion (HP:0005268)3.03957836
37Hypoglycemic coma (HP:0001325)3.03919208
38Ketoacidosis (HP:0001993)3.00267208
39Abnormal gallbladder physiology (HP:0012438)2.95133987
40Cholecystitis (HP:0001082)2.95133987
41Hyperbilirubinemia (HP:0002904)2.94127451
42Abnormality of pyrimidine metabolism (HP:0004353)2.93369921
43Metabolic acidosis (HP:0001942)2.90128685
44Acanthocytosis (HP:0001927)2.84925285
45Cerebral edema (HP:0002181)2.84843674
46Abnormality of serum amino acid levels (HP:0003112)2.80711679
47Hypochromic microcytic anemia (HP:0004840)2.76036599
48Status epilepticus (HP:0002133)2.75489585
49Abnormal gallbladder morphology (HP:0012437)2.70626560
50Mitral stenosis (HP:0001718)2.70063723
51Lethargy (HP:0001254)2.70001693
52Abnormality of nucleobase metabolism (HP:0010932)2.69104580
53Hypercholesterolemia (HP:0003124)2.68023493
54Menorrhagia (HP:0000132)2.67848014
55Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.67057373
56Skin nodule (HP:0200036)2.60898980
57Abnormality of fatty-acid metabolism (HP:0004359)2.59348215
58Delayed CNS myelination (HP:0002188)2.57015117
59Abnormality of purine metabolism (HP:0004352)2.56971909
60Steatorrhea (HP:0002570)2.51577610
61Gingival bleeding (HP:0000225)2.46930844
62Cholelithiasis (HP:0001081)2.45961870
63Epileptic encephalopathy (HP:0200134)2.45625179
64Neonatal onset (HP:0003623)2.43879847
65Rectovaginal fistula (HP:0000143)2.43219112
66Rectal fistula (HP:0100590)2.43219112
67Spastic diplegia (HP:0001264)2.42026055
68Abnormality of the lower motor neuron (HP:0002366)2.41383670
69Hypoglycemic seizures (HP:0002173)2.40961617
70Opisthotonus (HP:0002179)2.40587629
71Hyperinsulinemic hypoglycemia (HP:0000825)2.40128844
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.39703761
73Dicarboxylic aciduria (HP:0003215)2.39703761
74Generalized aminoaciduria (HP:0002909)2.39388989
75Nephritis (HP:0000123)2.37916908
76Increased serum pyruvate (HP:0003542)2.37278387
77Brushfield spots (HP:0001088)2.35000475
78Sensorimotor neuropathy (HP:0007141)2.34687896
79Rickets (HP:0002748)2.32998839
80Enlarged kidneys (HP:0000105)2.32937030
81Focal seizures (HP:0007359)2.32507628
82Abnormal biliary tract physiology (HP:0012439)2.22196689
83Bile duct proliferation (HP:0001408)2.22196689
84Vomiting (HP:0002013)2.21559546
85Abnormality of glycolysis (HP:0004366)2.21347228
86Osteomalacia (HP:0002749)2.20763665
87Atonic seizures (HP:0010819)2.20626214
88Reduced antithrombin III activity (HP:0001976)2.19933191
89Hyperphosphaturia (HP:0003109)2.18300749
90Intestinal fistula (HP:0100819)2.17309784
91Abnormality of the gallbladder (HP:0005264)2.16908156
92Vascular calcification (HP:0004934)2.16808387
93Abnormal tarsal ossification (HP:0008369)2.13686506
94Choanal stenosis (HP:0000452)2.11846589
95Testicular atrophy (HP:0000029)2.11752658
96Arthropathy (HP:0003040)2.11436629
97Irritability (HP:0000737)2.10692840
98Abnormal urine phosphate concentration (HP:0012599)2.10608929
99Hepatocellular carcinoma (HP:0001402)2.10217592
100Malnutrition (HP:0004395)2.09824982
101Abnormality of carpal bone ossification (HP:0006257)2.08800901
102Purpura (HP:0000979)2.06619168
103Widely patent fontanelles and sutures (HP:0004492)2.05987772
104Systemic lupus erythematosus (HP:0002725)2.05442828
105Fair hair (HP:0002286)2.03941548
106Dialeptic seizures (HP:0011146)2.01969859
107Acute hepatic failure (HP:0006554)1.98585118
108Acute encephalopathy (HP:0006846)1.98187012
109Febrile seizures (HP:0002373)1.97561140
110Cardiovascular calcification (HP:0011915)1.97166577
111Mesangial abnormality (HP:0001966)1.97140274
112Generalized tonic-clonic seizures (HP:0002069)1.96594433
113Myocardial infarction (HP:0001658)1.96000738
114Hypoplasia of the capital femoral epiphysis (HP:0003090)1.95013910
115Amyloidosis (HP:0011034)1.92118295
116Absence seizures (HP:0002121)1.91482936
117Rib fusion (HP:0000902)1.90479335
118Alkalosis (HP:0001948)1.89204995
119Pancreatic islet-cell hyperplasia (HP:0004510)1.88155130
120Lower limb hyperreflexia (HP:0002395)1.87973834
121Glycosuria (HP:0003076)1.86921898
122Abnormality of urine glucose concentration (HP:0011016)1.86921898
123Confusion (HP:0001289)1.86842996
124Increased purine levels (HP:0004368)1.86046886
125Hyperuricemia (HP:0002149)1.86046886
126Abnormality of the lumbar spine (HP:0100712)1.85152443
127* Thrombophlebitis (HP:0004418)1.84979170
128Chronic hepatic failure (HP:0100626)1.84606651
129Epileptiform EEG discharges (HP:0011182)1.83020774
130Abnormality of the Achilles tendon (HP:0005109)1.82558181
131Atrioventricular block (HP:0001678)1.79779039
132Ulnar bowing (HP:0003031)1.79429768
133Poor suck (HP:0002033)1.78988022
134Epiphyseal stippling (HP:0010655)1.78389075
135Facial shape deformation (HP:0011334)1.78298745
136Potter facies (HP:0002009)1.78298745
137Recurrent gram-negative bacterial infections (HP:0005420)1.78162925
138Oligomenorrhea (HP:0000876)1.78117784
139Poikilocytosis (HP:0004447)1.77612438
140Small epiphyses (HP:0010585)1.75249816
141Hypophosphatemic rickets (HP:0004912)1.74920682
142Popliteal pterygium (HP:0009756)1.70170449
143Broad alveolar ridges (HP:0000187)1.66052139
144Hepatoblastoma (HP:0002884)1.64904150
145Abnormality of the vitreous humor (HP:0004327)1.64324573
146Facial hemangioma (HP:0000329)1.63699748
147* Abnormal delivery (HP:0001787)1.61809905
148Absent epiphyses (HP:0010577)1.53680891
149Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.53680891
150Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.52247739
151Abnormality of alanine metabolism (HP:0010916)1.52247739
152Hyperalaninemia (HP:0003348)1.52247739

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.54298013
2CASK4.48070121
3BCKDK3.90554708
4EPHA43.78061003
5NTRK33.48405387
6AKT33.45320434
7DAPK23.29221767
8BMPR23.04330591
9ICK2.95452293
10MAP2K42.78901485
11MAP3K42.32577511
12DAPK12.30648362
13FGFR32.27408669
14SIK12.25328206
15MAP2K72.18004295
16STK162.08701192
17ERBB32.05398304
18PRPF4B2.03448208
19ERBB41.95376751
20ERN11.91806719
21PKN21.90678530
22INSRR1.87965793
23MAP3K121.83219602
24SIK31.82612388
25NME11.75020459
26BMPR1B1.74431556
27FGFR41.73417229
28ACVR1B1.71667141
29RIPK11.68549234
30TRIB31.63778326
31PRKCG1.59139224
32TYRO31.58089086
33WNK11.58046396
34MUSK1.56065608
35CAMK1D1.53464228
36SGK21.49967434
37DYRK1B1.46924489
38CDK121.42456094
39PLK21.36048768
40FRK1.35353911
41LATS21.35218921
42CDK191.35192613
43PTK2B1.29612927
44NEK21.20757272
45PDGFRA1.19725870
46PINK11.19257715
47OXSR11.18926474
48SGK31.17989752
49TSSK61.17158972
50SGK4941.16658040
51SGK2231.16658040
52CAMK2B1.12426007
53SMG11.11498126
54STK391.09392841
55CAMK2G1.09024621
56CSNK1E1.08650780
57FGFR21.07544140
58MAPK71.03878214
59PBK1.01791536
60PDK41.01680732
61PDK31.01680732
62CAMK2A1.00756314
63MAPK110.97173265
64STK38L0.96442558
65CDK70.95405776
66GRK60.94864068
67ERBB20.94369739
68PIK3CA0.93673193
69CAMK1G0.86211710
70MINK10.84832728
71PTK20.83530034
72MAP3K70.82706739
73BRAF0.82306711
74PLK40.81341149
75CSNK1D0.80149530
76BMX0.79835231
77NTRK20.79041086
78ADRBK20.76747936
79SIK20.76389410
80CDC70.74172276
81MST1R0.74169943
82TNIK0.73059183
83GRK50.72255663
84CCNB10.71716096
85MAPK150.71263368
86MAP3K100.68604235
87EIF2AK10.68383937
88PRKCZ0.67431848
89BUB10.65682696
90BRSK10.65444475
91LATS10.65211429
92PRKCE0.63861728
93CAMK40.63545516
94CSNK2A20.62463369
95CDK150.62359557
96EEF2K0.62176668
97DYRK20.62100574
98MAPK120.61858537
99OBSCN0.60266273
100CDK40.59525106
101PLK10.59189073
102TTK0.58076199
103CDK11A0.57774350
104MTOR0.57654849
105DAPK30.57640225
106NEK90.57087638
107CSNK2A10.56666424
108TAOK30.56209860
109AKT20.54759562
110PTK60.54335045
111CDK180.54319452
112FER0.54079518
113PDK20.52371705
114MYLK0.52140378
115RET0.51809951
116GRK10.50563888
117PRKACG0.50130291
118PDK10.49919344
119SRPK10.49547113
120CDK10.49348276
121MAP3K60.48892863
122SGK10.48680256
123CAMK2D0.47936198
124MAP3K130.47912825
125CDC42BPA0.47609013
126PIK3CG0.47541311
127RPS6KB10.47539490
128CDK80.47289235
129CDK50.47121691
130IRAK20.46836769
131PRKAA20.46662684
132ABL20.46651603
133MAPK130.44916135
134NTRK10.44430030
135MKNK20.43892754
136CDK20.43099839
137ADRBK10.42742455
138PRKCA0.42681622
139DDR20.42398031
140PRKACA0.41198563
141FGFR10.40718346
142ATR0.40429141
143JAK20.40346801
144RIPK40.39273180
145ARAF0.39100617
146PHKG20.38747491
147PHKG10.38747491
148STK380.37404492
149MATK0.37201278
150CDK30.36096010
151KSR10.35210904
152MAPK80.35118610
153GSK3B0.33910410
154PRKCB0.33787046
155WNK30.33614309
156PRKAA10.33414173
157CAMKK10.33155467
158MARK20.32930376
159PRKDC0.32588340
160RPS6KA30.32460082
161PRKCH0.30191634
162PRKG10.29439570
163MAPK40.27848298
164PDPK10.26751380
165MAP2K60.26146542

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.30181094
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.80748225
3Arginine biosynthesis_Homo sapiens_hsa002203.06454557
4Nitrogen metabolism_Homo sapiens_hsa009102.77033250
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.76886833
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.73749504
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63536053
8Tryptophan metabolism_Homo sapiens_hsa003802.48437032
9Complement and coagulation cascades_Homo sapiens_hsa046102.41431918
10Butanoate metabolism_Homo sapiens_hsa006502.33264787
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.26477185
12Fatty acid degradation_Homo sapiens_hsa000712.25005624
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14499293
14Peroxisome_Homo sapiens_hsa041462.04063348
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.02936704
16Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.89230967
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.82260031
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82215125
19Propanoate metabolism_Homo sapiens_hsa006401.78536607
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.78493253
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.76053737
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.71974959
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71597825
24Fatty acid metabolism_Homo sapiens_hsa012121.69980877
25Pyruvate metabolism_Homo sapiens_hsa006201.65785203
26Chemical carcinogenesis_Homo sapiens_hsa052041.62304593
27PPAR signaling pathway_Homo sapiens_hsa033201.62202802
28Histidine metabolism_Homo sapiens_hsa003401.61569764
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58836770
30Phenylalanine metabolism_Homo sapiens_hsa003601.58814800
31beta-Alanine metabolism_Homo sapiens_hsa004101.47368665
32Bile secretion_Homo sapiens_hsa049761.44978809
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.43880706
34Retinol metabolism_Homo sapiens_hsa008301.42518154
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.41420484
36Tyrosine metabolism_Homo sapiens_hsa003501.35193285
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33728482
38Sulfur metabolism_Homo sapiens_hsa009201.28676193
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26898783
40Biosynthesis of amino acids_Homo sapiens_hsa012301.26812154
41Fatty acid elongation_Homo sapiens_hsa000621.22912687
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.21590712
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.20627976
44Staphylococcus aureus infection_Homo sapiens_hsa051501.19964126
45Carbon metabolism_Homo sapiens_hsa012001.18554040
46Starch and sucrose metabolism_Homo sapiens_hsa005001.12389566
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12175454
48Other glycan degradation_Homo sapiens_hsa005111.11335992
49Nicotine addiction_Homo sapiens_hsa050331.05086494
50Selenocompound metabolism_Homo sapiens_hsa004501.01362752
51Caffeine metabolism_Homo sapiens_hsa002320.99860270
52Collecting duct acid secretion_Homo sapiens_hsa049660.99724974
53ABC transporters_Homo sapiens_hsa020100.92987182
54Vitamin B6 metabolism_Homo sapiens_hsa007500.90173478
55Arginine and proline metabolism_Homo sapiens_hsa003300.90121508
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.88307445
57Fat digestion and absorption_Homo sapiens_hsa049750.84624394
58Folate biosynthesis_Homo sapiens_hsa007900.81849187
59Linoleic acid metabolism_Homo sapiens_hsa005910.81681047
60Synaptic vesicle cycle_Homo sapiens_hsa047210.80365112
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80042030
62Vitamin digestion and absorption_Homo sapiens_hsa049770.79057393
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78789520
64Steroid biosynthesis_Homo sapiens_hsa001000.74620765
65Glycerolipid metabolism_Homo sapiens_hsa005610.63447623
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62787237
67Sulfur relay system_Homo sapiens_hsa041220.60290664
68Arachidonic acid metabolism_Homo sapiens_hsa005900.57165928
69GABAergic synapse_Homo sapiens_hsa047270.56806903
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54809496
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54051357
72Lysine degradation_Homo sapiens_hsa003100.50187180
73Metabolic pathways_Homo sapiens_hsa011000.49568155
74N-Glycan biosynthesis_Homo sapiens_hsa005100.49366038
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49266128
76Sphingolipid metabolism_Homo sapiens_hsa006000.48199243
77Glutathione metabolism_Homo sapiens_hsa004800.42620470
78Fatty acid biosynthesis_Homo sapiens_hsa000610.39870466
79One carbon pool by folate_Homo sapiens_hsa006700.39635661
80Amphetamine addiction_Homo sapiens_hsa050310.37228267
81Thyroid hormone synthesis_Homo sapiens_hsa049180.37009232
82Glucagon signaling pathway_Homo sapiens_hsa049220.36902178
83Fructose and mannose metabolism_Homo sapiens_hsa000510.35853526
84Circadian entrainment_Homo sapiens_hsa047130.34854570
85Prion diseases_Homo sapiens_hsa050200.33862238
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33141607
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32268884
88Galactose metabolism_Homo sapiens_hsa000520.31583319
89Glutamatergic synapse_Homo sapiens_hsa047240.31503424
90Taste transduction_Homo sapiens_hsa047420.31225179
91Morphine addiction_Homo sapiens_hsa050320.30200812
92Olfactory transduction_Homo sapiens_hsa047400.29741949
93Pentose phosphate pathway_Homo sapiens_hsa000300.29521119
94Vibrio cholerae infection_Homo sapiens_hsa051100.24631173
95Renin-angiotensin system_Homo sapiens_hsa046140.24592855
96Insulin secretion_Homo sapiens_hsa049110.23896186
97Oxidative phosphorylation_Homo sapiens_hsa001900.23703499
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.23583635
99Mineral absorption_Homo sapiens_hsa049780.22617978
100Proteasome_Homo sapiens_hsa030500.22033399
101Long-term potentiation_Homo sapiens_hsa047200.21533479
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17710176
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16302959
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.15341228
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13027434
106Insulin resistance_Homo sapiens_hsa049310.11441381
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.10235540
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09830892
109Calcium signaling pathway_Homo sapiens_hsa040200.09793706
110Dopaminergic synapse_Homo sapiens_hsa047280.08650454
111Ovarian steroidogenesis_Homo sapiens_hsa049130.08514176
112Circadian rhythm_Homo sapiens_hsa047100.05647815
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.03124223
114Salivary secretion_Homo sapiens_hsa049700.03114490
115AMPK signaling pathway_Homo sapiens_hsa041520.01487332
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0539545
117TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0522004
118Non-homologous end-joining_Homo sapiens_hsa03450-0.0444429
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0261447
120Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0156415
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0102866
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0038512
123Pertussis_Homo sapiens_hsa05133-0.0009090

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