THRA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.44133180
2locomotory exploration behavior (GO:0035641)6.30190928
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.17302567
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.67058367
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.56953669
6vocalization behavior (GO:0071625)5.49581410
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.30603687
8layer formation in cerebral cortex (GO:0021819)5.21663015
9synaptic vesicle exocytosis (GO:0016079)5.07643456
10glutamate secretion (GO:0014047)5.03059296
11regulation of glutamate receptor signaling pathway (GO:1900449)4.95520341
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.92735831
13exploration behavior (GO:0035640)4.90035197
14regulation of synaptic vesicle exocytosis (GO:2000300)4.89996741
15protein localization to synapse (GO:0035418)4.76312670
16regulation of synapse structural plasticity (GO:0051823)4.75406009
17dendritic spine morphogenesis (GO:0060997)4.65970860
18regulation of neuronal synaptic plasticity (GO:0048168)4.55856724
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.52450860
20L-amino acid import (GO:0043092)4.41742993
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.41002147
22neuron cell-cell adhesion (GO:0007158)4.39871680
23regulation of synaptic vesicle transport (GO:1902803)4.35125919
24neurotransmitter secretion (GO:0007269)4.23273756
25neurotransmitter-gated ion channel clustering (GO:0072578)4.11506514
26amino acid import (GO:0043090)4.05798308
27potassium ion homeostasis (GO:0055075)3.99458449
28proline transport (GO:0015824)3.98274209
29synaptic transmission, glutamatergic (GO:0035249)3.93919113
30axon ensheathment in central nervous system (GO:0032291)3.91868931
31central nervous system myelination (GO:0022010)3.91868931
32potassium ion import (GO:0010107)3.90727130
33positive regulation of synapse maturation (GO:0090129)3.87262251
34gamma-aminobutyric acid transport (GO:0015812)3.86978975
35regulation of dendritic spine morphogenesis (GO:0061001)3.85371265
36dendrite morphogenesis (GO:0048813)3.82328104
37glutamate receptor signaling pathway (GO:0007215)3.78141373
38long-term memory (GO:0007616)3.77643689
39positive regulation of membrane potential (GO:0045838)3.75614163
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.74103794
41neuron recognition (GO:0008038)3.73771758
42activation of protein kinase A activity (GO:0034199)3.69884124
43neuronal action potential propagation (GO:0019227)3.68625595
44neuromuscular process controlling balance (GO:0050885)3.65949620
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.61571304
46sodium ion export (GO:0071436)3.60648472
47neuron-neuron synaptic transmission (GO:0007270)3.58286083
48auditory behavior (GO:0031223)3.57794906
49cellular potassium ion homeostasis (GO:0030007)3.57306833
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.56529895
51axonal fasciculation (GO:0007413)3.51729034
52regulation of synaptic plasticity (GO:0048167)3.47438797
53cellular sodium ion homeostasis (GO:0006883)3.46171004
54cell migration in hindbrain (GO:0021535)3.45829740
55postsynaptic membrane organization (GO:0001941)3.44714343
56positive regulation of synaptic transmission, GABAergic (GO:0032230)3.40980454
57cytoskeletal anchoring at plasma membrane (GO:0007016)3.40284392
58regulation of postsynaptic membrane potential (GO:0060078)3.39898850
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.37019753
60cell communication by electrical coupling (GO:0010644)3.35116375
61transmission of nerve impulse (GO:0019226)3.33119036
62neurotransmitter transport (GO:0006836)3.32879528
63dendritic spine organization (GO:0097061)3.32727539
64synaptic vesicle endocytosis (GO:0048488)3.30254407
65cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.29118168
66positive regulation of dendritic spine development (GO:0060999)3.27856891
67response to auditory stimulus (GO:0010996)3.27560211
68negative regulation of synaptic transmission, GABAergic (GO:0032229)3.25701270
69neuronal ion channel clustering (GO:0045161)3.25003890
70regulation of neurotransmitter secretion (GO:0046928)3.23941006
71regulation of dendritic spine development (GO:0060998)3.23298875
72G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.21315584
73central nervous system projection neuron axonogenesis (GO:0021952)3.19843408
74prepulse inhibition (GO:0060134)3.18763842
75glycine transport (GO:0015816)3.17693873
76regulation of voltage-gated calcium channel activity (GO:1901385)3.15493569
77positive regulation of neurotransmitter secretion (GO:0001956)3.15480353
78positive regulation of dendritic spine morphogenesis (GO:0061003)3.15194762
79pyrimidine nucleobase catabolic process (GO:0006208)3.14507555
80regulation of ARF protein signal transduction (GO:0032012)3.13702186
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.13617924
82regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.11100517
83regulation of neurotransmitter levels (GO:0001505)3.10014525
84vesicle transport along microtubule (GO:0047496)3.09544120
85clathrin coat assembly (GO:0048268)3.09282916
86cerebellar Purkinje cell layer development (GO:0021680)3.08784201
87regulation of vesicle fusion (GO:0031338)3.07133299
88regulation of synaptic transmission, glutamatergic (GO:0051966)3.05778491
89long-term synaptic potentiation (GO:0060291)3.03528207
90cerebellar Purkinje cell differentiation (GO:0021702)3.02395928
91positive regulation of neurotransmitter transport (GO:0051590)3.00698545
92organelle transport along microtubule (GO:0072384)2.98560887
93regulation of neurotransmitter transport (GO:0051588)2.97383240
94innervation (GO:0060384)2.97175830
95learning (GO:0007612)2.95227074
96cell communication involved in cardiac conduction (GO:0086065)2.94621968
97positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94168593
98synapse assembly (GO:0007416)2.93634414
99dopamine receptor signaling pathway (GO:0007212)2.91251882
100regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.90642218
101social behavior (GO:0035176)2.90071453
102intraspecies interaction between organisms (GO:0051703)2.90071453
103regulation of synapse maturation (GO:0090128)2.89972803
104membrane depolarization (GO:0051899)2.89701528
105positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.89258761
106establishment of nucleus localization (GO:0040023)2.88349423
107behavioral fear response (GO:0001662)2.87950917
108behavioral defense response (GO:0002209)2.87950917
109membrane depolarization during action potential (GO:0086010)2.87891903
110neuromuscular process (GO:0050905)2.86074373
111membrane hyperpolarization (GO:0060081)2.84047470
112regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.83610993
113synapse organization (GO:0050808)2.83464099
114cerebellar granule cell differentiation (GO:0021707)2.83455301
115acidic amino acid transport (GO:0015800)2.82989926
116neurotransmitter uptake (GO:0001504)2.82665529
117gamma-aminobutyric acid signaling pathway (GO:0007214)2.82132731
118establishment of mitochondrion localization (GO:0051654)2.78408902
119negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.76160857
120negative regulation of dendrite morphogenesis (GO:0050774)2.75379462
121positive regulation of dendrite development (GO:1900006)2.74450117
122presynaptic membrane assembly (GO:0097105)2.71299387
123cellular response to catecholamine stimulus (GO:0071870)2.70875911
124cellular response to monoamine stimulus (GO:0071868)2.70875911
125presynaptic membrane organization (GO:0097090)2.70577860
126regulation of synaptic transmission (GO:0050804)2.69564406
127cell differentiation in hindbrain (GO:0021533)2.66773079
128detection of calcium ion (GO:0005513)2.65428343

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.59034014
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07683034
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.06172297
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05495673
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98843650
6GBX2_23144817_ChIP-Seq_PC3_Human2.82899390
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80145954
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80145954
9* RARB_27405468_Chip-Seq_BRAIN_Mouse2.74743686
10DROSHA_22980978_ChIP-Seq_HELA_Human2.71771679
11REST_21632747_ChIP-Seq_MESCs_Mouse2.68516183
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67205033
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58214955
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.57243822
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.55006979
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53186738
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48290345
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46982605
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.41296121
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37417117
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.31624364
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.28627239
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.28427902
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.24338391
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.14822008
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14603846
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.10622221
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04716405
29AR_21572438_ChIP-Seq_LNCaP_Human1.89704874
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85104668
31* LXR_22292898_ChIP-Seq_THP-1_Human1.77814033
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.72354928
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64563011
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.60451053
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.48237936
36KDM2B_26808549_Chip-Seq_K562_Human1.47465364
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47387255
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.47291140
39* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46383156
40SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43768777
41* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42059648
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40367323
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36032231
44* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34430586
45* KDM2B_26808549_Chip-Seq_DND41_Human1.32070927
46ZNF274_21170338_ChIP-Seq_K562_Hela1.31379135
47* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31190461
48SMAD4_21799915_ChIP-Seq_A2780_Human1.31171664
49* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30917970
50RING1B_27294783_Chip-Seq_NPCs_Mouse1.28065032
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27517767
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26934713
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26854684
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.24931543
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22586606
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21233926
57AR_19668381_ChIP-Seq_PC3_Human1.20431398
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20343393
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19436233
60SMC4_20622854_ChIP-Seq_HELA_Human1.18783511
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18688730
62TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18600082
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12394496
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11766618
65SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09793528
66PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09571344
67* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07711945
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06832063
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06614646
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06328471
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05756107
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.05665431
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05213611
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05124343
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03093393
76AR_25329375_ChIP-Seq_VCAP_Human1.02943005
77KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02743915
78OCT4_19829295_ChIP-Seq_ESCs_Human1.01238442
79STAT3_23295773_ChIP-Seq_U87_Human1.01023425
80CREB1_26743006_Chip-Seq_LNCaP_Human1.00944969
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.00377296
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00210841
83* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00116604
84CTCF_27219007_Chip-Seq_Bcells_Human0.99979573
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99342729
86SMAD4_21741376_ChIP-Seq_HESCs_Human0.98762419
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98211097
88TET1_21490601_ChIP-Seq_MESCs_Mouse0.97986084
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97078107
90ARNT_22903824_ChIP-Seq_MCF-7_Human0.96916587
91* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96204442
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95938164
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95763696
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95660648
95AHR_22903824_ChIP-Seq_MCF-7_Human0.95480531
96* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94504503
97SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94026362
98TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93816636
99P68_20966046_ChIP-Seq_HELA_Human0.93482854
100* TP53_23651856_ChIP-Seq_MEFs_Mouse0.93190275
101SMAD3_21741376_ChIP-Seq_ESCs_Human0.93115003
102SMAD_19615063_ChIP-ChIP_OVARY_Human0.91776017
103SMAD3_21741376_ChIP-Seq_HESCs_Human0.91671861
104TAF15_26573619_Chip-Seq_HEK293_Human0.90618018
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90245416
106* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90190112
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90082397
108P300_19829295_ChIP-Seq_ESCs_Human0.89902248
109* TCF7_22412390_ChIP-Seq_EML_Mouse0.89730231
110* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88649524
111TCF4_23295773_ChIP-Seq_U87_Human0.87599455
112ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87106228
113SA1_27219007_Chip-Seq_ERYTHROID_Human0.86134372
114TBX20_22080862_ChIP-Seq_HEART_Mouse0.85428040
115TBX20_22328084_ChIP-Seq_HEART_Mouse0.85428040
116DPY_21335234_ChIP-Seq_ESCs_Mouse0.85283388
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84447698
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83946182
119KDM2B_26808549_Chip-Seq_JURKAT_Human0.82913891
120RACK7_27058665_Chip-Seq_MCF-7_Human0.82303798
121* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.81869561
122PIAS1_25552417_ChIP-Seq_VCAP_Human0.81836318
123NFIB_24661679_ChIP-Seq_LUNG_Mouse0.81703727
124CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81379889
125TET1_21451524_ChIP-Seq_MESCs_Mouse0.81082994
126TP53_16413492_ChIP-PET_HCT116_Human0.80675271
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.80294519
128* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.80054191
129ZFP57_27257070_Chip-Seq_ESCs_Mouse0.79926949
130* GATA1_19941827_ChIP-Seq_MEL_Mouse0.79824066
131RXR_22108803_ChIP-Seq_LS180_Human0.79664550
132TP53_20018659_ChIP-ChIP_R1E_Mouse0.79655119
133RNF2_27304074_Chip-Seq_NSC_Mouse0.79635742
134KLF4_19829295_ChIP-Seq_ESCs_Human0.79419734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.37193863
2MP0003880_abnormal_central_pattern4.37507404
3MP0003635_abnormal_synaptic_transmissio4.32179948
4MP0004270_analgesia4.10114287
5* MP0002063_abnormal_learning/memory/cond3.45679166
6MP0009745_abnormal_behavioral_response3.35164386
7MP0005423_abnormal_somatic_nervous3.14108742
8MP0002064_seizures3.05203713
9MP0002822_catalepsy2.78548550
10MP0001968_abnormal_touch/_nociception2.73387347
11MP0002734_abnormal_mechanical_nocicepti2.72333786
12MP0009046_muscle_twitch2.69846592
13* MP0002572_abnormal_emotion/affect_behav2.66806786
14MP0001486_abnormal_startle_reflex2.55570053
15MP0002272_abnormal_nervous_system2.37374947
16MP0000778_abnormal_nervous_system2.24935286
17MP0003329_amyloid_beta_deposits2.16795177
18MP0004858_abnormal_nervous_system2.14750667
19MP0001440_abnormal_grooming_behavior2.13786189
20MP0002733_abnormal_thermal_nociception2.10204823
21MP0002735_abnormal_chemical_nociception2.07255442
22MP0004811_abnormal_neuron_physiology2.01756669
23MP0002736_abnormal_nociception_after1.98521732
24MP0001501_abnormal_sleep_pattern1.95950237
25MP0001970_abnormal_pain_threshold1.95609447
26MP0008569_lethality_at_weaning1.95278427
27MP0002184_abnormal_innervation1.86234415
28MP0002909_abnormal_adrenal_gland1.84239328
29MP0000955_abnormal_spinal_cord1.76880312
30MP0002067_abnormal_sensory_capabilities1.76825242
31MP0004924_abnormal_behavior1.74670757
32MP0005386_behavior/neurological_phenoty1.74670757
33* MP0002557_abnormal_social/conspecific_i1.71336630
34* MP0002882_abnormal_neuron_morphology1.51421593
35* MP0002066_abnormal_motor_capabilities/c1.45728955
36MP0003633_abnormal_nervous_system1.37634032
37MP0000751_myopathy1.37139432
38MP0003787_abnormal_imprinting1.30199576
39MP0005646_abnormal_pituitary_gland1.29791091
40MP0003123_paternal_imprinting1.28727391
41* MP0004130_abnormal_muscle_cell1.28581107
42MP0006276_abnormal_autonomic_nervous1.25931388
43* MP0002152_abnormal_brain_morphology1.23608536
44MP0001984_abnormal_olfaction1.23446161
45MP0000569_abnormal_digit_pigmentation1.21704317
46MP0003631_nervous_system_phenotype1.17187068
47MP0003283_abnormal_digestive_organ1.15443909
48MP0003705_abnormal_hypodermis_morpholog1.14612682
49MP0005645_abnormal_hypothalamus_physiol1.13065983
50MP0001502_abnormal_circadian_rhythm1.10974660
51* MP0004885_abnormal_endolymph1.10135846
52MP0001905_abnormal_dopamine_level1.06391890
53MP0001177_atelectasis1.06385335
54MP0003634_abnormal_glial_cell1.04990156
55MP0008961_abnormal_basal_metabolism1.04264773
56MP0000920_abnormal_myelination1.02592209
57MP0003690_abnormal_glial_cell1.02434728
58MP0003075_altered_response_to1.01351107
59MP0002249_abnormal_larynx_morphology0.99742138
60MP0005670_abnormal_white_adipose0.99382018
61MP0004142_abnormal_muscle_tone0.97415697
62MP0001529_abnormal_vocalization0.96732930
63MP0000604_amyloidosis0.96443463
64* MP0002069_abnormal_eating/drinking_beha0.93150338
65MP0002229_neurodegeneration0.92457891
66MP0003122_maternal_imprinting0.92027902
67MP0004145_abnormal_muscle_electrophysio0.91898174
68MP0000749_muscle_degeneration0.90437653
69MP0005623_abnormal_meninges_morphology0.89641931
70MP0003632_abnormal_nervous_system0.87916454
71MP0001958_emphysema0.87065871
72MP0008874_decreased_physiological_sensi0.86999591
73MP0000013_abnormal_adipose_tissue0.85828808
74MP0004742_abnormal_vestibular_system0.82854589
75* MP0003879_abnormal_hair_cell0.82550724
76MP0005167_abnormal_blood-brain_barrier0.81740630
77MP0002638_abnormal_pupillary_reflex0.81668541
78* MP0004085_abnormal_heartbeat0.81548178
79MP0008872_abnormal_physiological_respon0.81102345
80MP0004036_abnormal_muscle_relaxation0.78728914
81MP0002090_abnormal_vision0.78721929
82MP0000759_abnormal_skeletal_muscle0.78551837
83MP0004233_abnormal_muscle_weight0.78155143
84MP0005499_abnormal_olfactory_system0.76541094
85MP0005394_taste/olfaction_phenotype0.76541094
86MP0004147_increased_porphyrin_level0.76411867
87MP0005187_abnormal_penis_morphology0.76296798
88MP0001348_abnormal_lacrimal_gland0.75856771
89MP0004215_abnormal_myocardial_fiber0.75822696
90MP0004510_myositis0.74710621
91MP0004087_abnormal_muscle_fiber0.73775877
92* MP0003861_abnormal_nervous_system0.72935824
93MP0010234_abnormal_vibrissa_follicle0.72459715
94* MP0002752_abnormal_somatic_nervous0.72240748
95MP0002837_dystrophic_cardiac_calcinosis0.70697467
96MP0005551_abnormal_eye_electrophysiolog0.70280316
97MP0001299_abnormal_eye_distance/0.69608105
98MP0004484_altered_response_of0.68143350
99MP0002234_abnormal_pharynx_morphology0.67577590
100MP0001188_hyperpigmentation0.66987007
101MP0005666_abnormal_adipose_tissue0.66231452
102MP0002971_abnormal_brown_adipose0.65031165
103* MP0003137_abnormal_impulse_conducting0.63516800
104* MP0001963_abnormal_hearing_physiology0.63206990
105MP0003172_abnormal_lysosome_physiology0.62565940
106MP0003045_fibrosis0.62225008
107* MP0005535_abnormal_body_temperature0.62081797
108MP0005166_decreased_susceptibility_to0.61612930
109MP0005409_darkened_coat_color0.61516736
110* MP0000631_abnormal_neuroendocrine_gland0.61296778
111MP0001346_abnormal_lacrimal_gland0.59568201
112MP0002089_abnormal_postnatal_growth/wei0.59289596
113MP0001485_abnormal_pinna_reflex0.58579125
114MP0001943_abnormal_respiration0.57478402
115MP0000747_muscle_weakness0.57346591
116MP0001664_abnormal_digestion0.57228061
117MP0002106_abnormal_muscle_physiology0.56978506
118MP0010386_abnormal_urinary_bladder0.56566986
119MP0003279_aneurysm0.56498411
120MP0005375_adipose_tissue_phenotype0.55420434
121MP0003183_abnormal_peptide_metabolism0.55186045
122* MP0010769_abnormal_survival0.52963560
123MP0005388_respiratory_system_phenotype0.51267475
124MP0002133_abnormal_respiratory_system0.51267475

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.05283806
2Focal motor seizures (HP:0011153)5.97859605
3Visual hallucinations (HP:0002367)5.07429974
4Focal seizures (HP:0007359)4.98528357
5Supranuclear gaze palsy (HP:0000605)4.12076320
6Epileptic encephalopathy (HP:0200134)4.04436548
7Ankle clonus (HP:0011448)3.98180254
8Action tremor (HP:0002345)3.87135058
9Mutism (HP:0002300)3.80006222
10Progressive cerebellar ataxia (HP:0002073)3.70435470
11Papilledema (HP:0001085)3.61512525
12Poor eye contact (HP:0000817)3.45050244
13Atonic seizures (HP:0010819)3.31061059
14Broad-based gait (HP:0002136)3.29820188
15Depression (HP:0000716)3.24403065
16Generalized tonic-clonic seizures (HP:0002069)3.23969068
17Impaired vibration sensation in the lower limbs (HP:0002166)3.21551080
18Febrile seizures (HP:0002373)3.20591711
19Absence seizures (HP:0002121)3.20557320
20Neurofibrillary tangles (HP:0002185)3.18658813
21Urinary bladder sphincter dysfunction (HP:0002839)3.17506289
22Impaired social interactions (HP:0000735)3.10809780
23Abnormal social behavior (HP:0012433)3.10809780
24Torticollis (HP:0000473)3.09252032
25Cerebral inclusion bodies (HP:0100314)3.08505336
26Megalencephaly (HP:0001355)3.05117680
27Abnormality of the lower motor neuron (HP:0002366)3.04400521
28Urinary urgency (HP:0000012)2.94566108
29Peripheral hypomyelination (HP:0007182)2.94387449
30Postural instability (HP:0002172)2.90633477
31Dialeptic seizures (HP:0011146)2.89982050
32Abnormal eating behavior (HP:0100738)2.89973727
33Anxiety (HP:0000739)2.88320636
34Dysdiadochokinesis (HP:0002075)2.83335536
35Focal dystonia (HP:0004373)2.82356446
36Amyotrophic lateral sclerosis (HP:0007354)2.81825602
37Abnormality of the corticospinal tract (HP:0002492)2.81679719
38Dysmetria (HP:0001310)2.81508341
39Genetic anticipation (HP:0003743)2.76186738
40Spastic gait (HP:0002064)2.72682504
41Excessive salivation (HP:0003781)2.70865319
42Drooling (HP:0002307)2.70865319
43Obstructive sleep apnea (HP:0002870)2.70696591
44Insomnia (HP:0100785)2.69621286
45Gaze-evoked nystagmus (HP:0000640)2.67517511
46Intention tremor (HP:0002080)2.66245629
47Insidious onset (HP:0003587)2.65361516
48Termporal pattern (HP:0011008)2.65361516
49Amblyopia (HP:0000646)2.63447271
50Hyporeflexia of lower limbs (HP:0002600)2.61916595
51Limb dystonia (HP:0002451)2.59375679
52Hemiparesis (HP:0001269)2.56206699
53Craniofacial dystonia (HP:0012179)2.55391532
54Truncal ataxia (HP:0002078)2.54876217
55Ventricular fibrillation (HP:0001663)2.54374296
56Progressive inability to walk (HP:0002505)2.52120824
57Tetraplegia (HP:0002445)2.50034384
58Stereotypic behavior (HP:0000733)2.49881686
59Abnormality of binocular vision (HP:0011514)2.48515559
60Diplopia (HP:0000651)2.48515559
61Exercise-induced myalgia (HP:0003738)2.47349296
62Lower limb muscle weakness (HP:0007340)2.41184346
63Bradykinesia (HP:0002067)2.37011525
64Pointed chin (HP:0000307)2.36879188
65Hyperventilation (HP:0002883)2.35450178
66Turricephaly (HP:0000262)2.29408544
67Apathy (HP:0000741)2.29261032
68Annular pancreas (HP:0001734)2.28995917
69Hemiplegia (HP:0002301)2.28762179
70Akinesia (HP:0002304)2.26964542
71Cerebral hypomyelination (HP:0006808)2.26518486
72Foot dorsiflexor weakness (HP:0009027)2.25853908
73Impaired smooth pursuit (HP:0007772)2.22664262
74Bundle branch block (HP:0011710)2.20995608
75Polyphagia (HP:0002591)2.19033058
76Muscle fiber splitting (HP:0003555)2.18489905
77Type 1 muscle fiber predominance (HP:0003803)2.18328753
78Fetal akinesia sequence (HP:0001989)2.18190364
79EEG with generalized epileptiform discharges (HP:0011198)2.17649651
80Epileptiform EEG discharges (HP:0011182)2.17075375
81Inappropriate behavior (HP:0000719)2.15858516
82Hypsarrhythmia (HP:0002521)2.15723429
83Shallow orbits (HP:0000586)2.14208714
84Scanning speech (HP:0002168)2.11494506
85Abnormality of the foot musculature (HP:0001436)2.10935737
86Clonus (HP:0002169)2.09555679
87Increased variability in muscle fiber diameter (HP:0003557)2.09466727
88Increased circulating renin level (HP:0000848)2.09125669
89Lower limb amyotrophy (HP:0007210)2.09094243
90Agitation (HP:0000713)2.07144687
91Impaired vibratory sensation (HP:0002495)2.05873762
92Heart block (HP:0012722)2.03574502
93Diminished motivation (HP:0000745)2.01230429
94Sudden death (HP:0001699)2.00775457
95Centrally nucleated skeletal muscle fibers (HP:0003687)1.99859776
96Pheochromocytoma (HP:0002666)1.99820177
97Rapidly progressive (HP:0003678)1.98951536
98Aplasia involving bones of the extremities (HP:0009825)1.98850462
99Aplasia involving bones of the upper limbs (HP:0009823)1.98850462
100Aplasia of the phalanges of the hand (HP:0009802)1.98850462
101Difficulty running (HP:0009046)1.98511932
102Abnormality of ocular smooth pursuit (HP:0000617)1.98151862
103Dysmetric saccades (HP:0000641)1.96178612
104Abnormal atrioventricular conduction (HP:0005150)1.96102456
105Bronchomalacia (HP:0002780)1.95717905
106Delusions (HP:0000746)1.92251767
107Prolonged QT interval (HP:0001657)1.90989765
108Ankyloglossia (HP:0010296)1.90607818
109Neuronal loss in central nervous system (HP:0002529)1.90448930
110Spinal canal stenosis (HP:0003416)1.90243150
111Lower limb asymmetry (HP:0100559)1.89065236
112Absent speech (HP:0001344)1.89035648
113Abnormal EKG (HP:0003115)1.88209279
114Generalized myoclonic seizures (HP:0002123)1.86762822
115Hyperacusis (HP:0010780)1.85921702
116Hypoplasia of the brainstem (HP:0002365)1.85046621
117Aplasia/Hypoplasia of the brainstem (HP:0007362)1.85046621
118Inability to walk (HP:0002540)1.84744759
119Abnormality of skeletal muscle fiber size (HP:0012084)1.81511195
120Hypercortisolism (HP:0001578)1.81209946
121Cerebral aneurysm (HP:0004944)1.79393753
122Bowel incontinence (HP:0002607)1.79222067
123Slow progression (HP:0003677)1.78327205
124Atrioventricular block (HP:0001678)1.78026269
125Sleep apnea (HP:0010535)1.77645391
126Morphological abnormality of the pyramidal tract (HP:0002062)1.77515457
127Intellectual disability, profound (HP:0002187)1.77500521
128Pachygyria (HP:0001302)1.77080824
129Status epilepticus (HP:0002133)1.76828516
130Rigidity (HP:0002063)1.76208355
131Aqueductal stenosis (HP:0002410)1.75827995

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.83143265
2MAP3K94.04728809
3EPHA43.93281513
4NTRK33.65177041
5MINK12.77726014
6DAPK22.58685901
7MAP3K42.56955254
8PAK62.48331314
9PRKD32.39909208
10KSR22.29196706
11NTRK22.19203092
12CAMKK12.07989914
13MAP2K71.95535303
14NTRK11.83089310
15KSR11.71447535
16PHKG11.71419727
17PHKG21.71419727
18CDK51.61720369
19TYRO31.57343307
20MAP2K41.51751789
21SIK21.51320126
22LATS21.48069697
23MAPK131.41221563
24TAOK11.32024119
25TNIK1.29624514
26DAPK11.27144984
27MAP3K21.25321354
28STK381.21992652
29PRPF4B1.19432089
30UHMK11.17242854
31PLK21.12451313
32GRK51.10914204
33MAP3K121.10289460
34PRKCG1.09481375
35CDK191.05142470
36FES1.02937722
37LMTK21.02868901
38CAMK2G1.00592205
39STK110.99327300
40RET0.98713371
41ARAF0.96708040
42CDK150.96563230
43CDK180.95701345
44ALK0.95225056
45CDK140.94490587
46RIPK40.94443541
47MARK20.93315540
48PRKCH0.92982790
49NEK60.91476037
50TNK20.88591983
51PAK30.88471600
52EEF2K0.88188822
53CSNK1G20.86879012
54CAMK10.86058265
55PNCK0.85623954
56CDK11A0.84703369
57RIPK10.84496866
58CAMKK20.80376265
59CAMK2A0.79042278
60OBSCN0.77670969
61SGK4940.76174161
62SGK2230.76174161
63MAP3K130.74486617
64TRIB30.73577656
65TTN0.72627400
66RAF10.72584867
67DYRK1A0.71398148
68ROCK20.69129520
69CASK0.66515553
70PRKCZ0.66419544
71CAMK2D0.65752313
72PINK10.65741665
73PDK10.65554009
74DYRK20.64298186
75PTK2B0.64192448
76PDPK10.63031040
77SIK10.62671325
78DMPK0.62053205
79ICK0.61498146
80SCYL20.60363955
81SGK10.60084936
82CAMK2B0.58887303
83WNK10.58577184
84MAP3K110.57759287
85CAMK1G0.57593427
86ERBB30.57454430
87ROCK10.56654639
88PKN10.55736195
89FYN0.55447793
90CDK120.54853200
91TESK10.54527238
92SGK30.54032682
93OXSR10.53766553
94DDR20.51693088
95NEK10.50860096
96FGFR20.50272418
97MAPK40.50042086
98RPS6KA20.48155723
99CAMK1D0.47643906
100MAP3K10.47261419
101CDC42BPA0.47075038
102MAP3K70.46944915
103BRSK10.45458951
104LIMK10.44989135
105* RPS6KA30.44794095
106PRKG20.43995725
107DAPK30.43720070
108MAPK120.43587014
109ERBB20.43229795
110PRKD10.43159212
111SGK20.43145161
112PDGFRA0.41350980
113PRKCE0.40425785
114CAMK40.39762296
115BRAF0.39097817
116MAPK100.38821859
117PKN20.37674402
118MAP3K60.37513242
119MAP2K10.35370413
120CSNK1G30.32638801

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.00547246
2Synaptic vesicle cycle_Homo sapiens_hsa047212.95318919
3Olfactory transduction_Homo sapiens_hsa047402.70264097
4Circadian entrainment_Homo sapiens_hsa047132.60734371
5GABAergic synapse_Homo sapiens_hsa047272.51625781
6Long-term potentiation_Homo sapiens_hsa047202.47852998
7Glutamatergic synapse_Homo sapiens_hsa047242.46726621
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.34864565
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.30096187
10Morphine addiction_Homo sapiens_hsa050322.29972343
11Amphetamine addiction_Homo sapiens_hsa050312.19896967
12Dopaminergic synapse_Homo sapiens_hsa047282.11474169
13Salivary secretion_Homo sapiens_hsa049702.02323179
14Cholinergic synapse_Homo sapiens_hsa047251.98426767
15Gastric acid secretion_Homo sapiens_hsa049711.90606139
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85186209
17Insulin secretion_Homo sapiens_hsa049111.84667591
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77756231
19Oxytocin signaling pathway_Homo sapiens_hsa049211.65909058
20Renin secretion_Homo sapiens_hsa049241.60160594
21Cocaine addiction_Homo sapiens_hsa050301.59483688
22Long-term depression_Homo sapiens_hsa047301.59482497
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59352030
24Gap junction_Homo sapiens_hsa045401.49886921
25GnRH signaling pathway_Homo sapiens_hsa049121.49331580
26Axon guidance_Homo sapiens_hsa043601.47035102
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42558778
28Serotonergic synapse_Homo sapiens_hsa047261.42484052
29Calcium signaling pathway_Homo sapiens_hsa040201.40244057
30Taste transduction_Homo sapiens_hsa047421.37121813
31Glioma_Homo sapiens_hsa052141.33885334
32Nitrogen metabolism_Homo sapiens_hsa009101.33201063
33Type II diabetes mellitus_Homo sapiens_hsa049301.27309391
34Estrogen signaling pathway_Homo sapiens_hsa049151.26161824
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26087194
36cAMP signaling pathway_Homo sapiens_hsa040241.26018185
37ErbB signaling pathway_Homo sapiens_hsa040121.16539348
38Melanogenesis_Homo sapiens_hsa049161.11524434
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11174927
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08785209
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05722345
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03414180
43Vitamin B6 metabolism_Homo sapiens_hsa007501.02123802
44Phospholipase D signaling pathway_Homo sapiens_hsa040720.98051024
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95974351
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95515657
47Dorso-ventral axis formation_Homo sapiens_hsa043200.91548813
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.90693960
49Oocyte meiosis_Homo sapiens_hsa041140.90517262
50Dilated cardiomyopathy_Homo sapiens_hsa054140.85793020
51Cardiac muscle contraction_Homo sapiens_hsa042600.85687050
52VEGF signaling pathway_Homo sapiens_hsa043700.83205273
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.82822726
54Choline metabolism in cancer_Homo sapiens_hsa052310.81371168
55Endometrial cancer_Homo sapiens_hsa052130.80905516
56Collecting duct acid secretion_Homo sapiens_hsa049660.79968542
57Pancreatic secretion_Homo sapiens_hsa049720.76968671
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76199272
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75350446
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73448952
61Thyroid hormone synthesis_Homo sapiens_hsa049180.73152298
62MAPK signaling pathway_Homo sapiens_hsa040100.71501840
63Renal cell carcinoma_Homo sapiens_hsa052110.70576515
64mTOR signaling pathway_Homo sapiens_hsa041500.69887224
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.67695477
66Circadian rhythm_Homo sapiens_hsa047100.67056640
67Endocytosis_Homo sapiens_hsa041440.66720126
68AMPK signaling pathway_Homo sapiens_hsa041520.65820819
69Ras signaling pathway_Homo sapiens_hsa040140.65314021
70Rap1 signaling pathway_Homo sapiens_hsa040150.65220363
71Arginine biosynthesis_Homo sapiens_hsa002200.63515479
72* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63347985
73Non-small cell lung cancer_Homo sapiens_hsa052230.62333953
74Arginine and proline metabolism_Homo sapiens_hsa003300.60365371
75Phototransduction_Homo sapiens_hsa047440.59264790
76* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58490305
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57489796
78Vibrio cholerae infection_Homo sapiens_hsa051100.57158862
79Glucagon signaling pathway_Homo sapiens_hsa049220.56645841
80Bile secretion_Homo sapiens_hsa049760.56380150
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55832821
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55687121
83Insulin signaling pathway_Homo sapiens_hsa049100.55679588
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54230314
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52382694
86Colorectal cancer_Homo sapiens_hsa052100.51999968
87Alcoholism_Homo sapiens_hsa050340.51243279
88Histidine metabolism_Homo sapiens_hsa003400.49989036
89Prion diseases_Homo sapiens_hsa050200.49897803
90Wnt signaling pathway_Homo sapiens_hsa043100.49871836
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49065979
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47577715
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47270647
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45733545
95Fatty acid biosynthesis_Homo sapiens_hsa000610.45353186
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41808085
97Focal adhesion_Homo sapiens_hsa045100.41720604
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41500527
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40885214
100PPAR signaling pathway_Homo sapiens_hsa033200.40687317
101Tight junction_Homo sapiens_hsa045300.40654200
102Chemokine signaling pathway_Homo sapiens_hsa040620.40315882
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39605168
104Ovarian steroidogenesis_Homo sapiens_hsa049130.39604782
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.38242965
106Inositol phosphate metabolism_Homo sapiens_hsa005620.38028440
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.37479704
108Notch signaling pathway_Homo sapiens_hsa043300.35092373
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34873658
110Platelet activation_Homo sapiens_hsa046110.34037807
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33311473
112Prolactin signaling pathway_Homo sapiens_hsa049170.31070407
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30668324
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30152750

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