ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	7.72585024
2	cytidine deamination (GO:0009972)	6.12759173
3	cytidine metabolic process (GO:0046087)	6.12759173
4	cytidine catabolic process (GO:0006216)	6.12759173
5	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.15865990
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.70637921
7	behavioral response to nicotine (GO:0035095)	4.57582899
8	L-fucose catabolic process (GO:0042355)	4.40451112
9	fucose catabolic process (GO:0019317)	4.40451112
10	L-fucose metabolic process (GO:0042354)	4.40451112
11	water-soluble vitamin biosynthetic process (GO:0042364)	4.35742750
12	platelet dense granule organization (GO:0060155)	4.31033979
13	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.93386852
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.88242741
15	NADH dehydrogenase complex assembly (GO:0010257)	3.88242741
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.88242741
17	adaptation of signaling pathway (GO:0023058)	3.74354172
18	protein complex biogenesis (GO:0070271)	3.74009012
19	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.71601516
20	cellular response to interferon-beta (GO:0035458)	3.67167648
21	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.58904339
22	anterograde synaptic vesicle transport (GO:0048490)	3.57855336
23	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.57297072
24	mitochondrial respiratory chain complex assembly (GO:0033108)	3.55001304
25	negative regulation of T cell differentiation in thymus (GO:0033085)	3.42794097
26	negative regulation by host of viral transcription (GO:0043922)	3.37383943
27	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.36432771
28	cellular ketone body metabolic process (GO:0046950)	3.30521567
29	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	3.30216213
30	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	3.30216213
31	signal peptide processing (GO:0006465)	3.26443281
32	rRNA modification (GO:0000154)	3.22830556
33	kynurenine metabolic process (GO:0070189)	3.21374315
34	positive regulation of defense response to virus by host (GO:0002230)	3.19731427
35	respiratory chain complex IV assembly (GO:0008535)	3.11558227
36	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.08731510
37	anterograde axon cargo transport (GO:0008089)	3.02067433
38	regulation of acrosome reaction (GO:0060046)	2.94899069
39	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.90983248
40	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.90983248
41	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.90755995
42	ketone body metabolic process (GO:1902224)	2.90582375
43	regulation of neurotransmitter uptake (GO:0051580)	2.89950792
44	negative regulation of thymocyte apoptotic process (GO:0070244)	2.88641318
45	rRNA methylation (GO:0031167)	2.87608458
46	rRNA catabolic process (GO:0016075)	2.87078362
47	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.86856786
48	chaperone-mediated protein transport (GO:0072321)	2.86295201
49	negative regulation of telomere maintenance (GO:0032205)	2.83722885
50	protein neddylation (GO:0045116)	2.83580711
51	electron transport chain (GO:0022900)	2.83228679
52	primary amino compound metabolic process (GO:1901160)	2.82703631
53	tryptophan metabolic process (GO:0006568)	2.81881331
54	positive regulation of respiratory burst (GO:0060267)	2.81366267
55	mitochondrial RNA metabolic process (GO:0000959)	2.80617688
56	proteasome assembly (GO:0043248)	2.77715643
57	tryptophan catabolic process (GO:0006569)	2.75642511
58	indole-containing compound catabolic process (GO:0042436)	2.75642511
59	indolalkylamine catabolic process (GO:0046218)	2.75642511
60	respiratory electron transport chain (GO:0022904)	2.74395946
61	replicative senescence (GO:0090399)	2.73310195
62	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.72056823
63	ATP synthesis coupled proton transport (GO:0015986)	2.70810107
64	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.70810107
65	histone H3-K9 demethylation (GO:0033169)	2.70388028
66	eosinophil chemotaxis (GO:0048245)	2.69262071
67	serotonin metabolic process (GO:0042428)	2.69104866
68	acrosome reaction (GO:0007340)	2.67804607
69	indolalkylamine metabolic process (GO:0006586)	2.67235173
70	intracellular protein transmembrane import (GO:0044743)	2.65172965
71	mitochondrion morphogenesis (GO:0070584)	2.63986386
72	peristalsis (GO:0030432)	2.62416840
73	prepulse inhibition (GO:0060134)	2.61096556
74	cytochrome complex assembly (GO:0017004)	2.59676980
75	positive regulation of prostaglandin secretion (GO:0032308)	2.59337935
76	regulation of thymocyte apoptotic process (GO:0070243)	2.55204331
77	protein-cofactor linkage (GO:0018065)	2.53247289
78	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.52888417
79	telomere maintenance via telomerase (GO:0007004)	2.49908681
80	indole-containing compound metabolic process (GO:0042430)	2.48127992
81	pseudouridine synthesis (GO:0001522)	2.48107786
82	response to interferon-beta (GO:0035456)	2.47956281
83	preassembly of GPI anchor in ER membrane (GO:0016254)	2.46572453
84	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.41539990
85	eosinophil migration (GO:0072677)	2.41162228
86	regulation of chronic inflammatory response (GO:0002676)	2.39794164
87	piRNA metabolic process (GO:0034587)	2.39790627
88	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.37353043
89	protein localization to cilium (GO:0061512)	2.36562344
90	cAMP catabolic process (GO:0006198)	2.34894470
91	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.34848374
92	sulfate transmembrane transport (GO:1902358)	2.33858511
93	regulation of cellular amino acid metabolic process (GO:0006521)	2.29806038
94	pyrimidine nucleoside catabolic process (GO:0046135)	2.29072969
95	activation of adenylate cyclase activity (GO:0007190)	2.25361434
96	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.25325325
97	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.25325325
98	isotype switching (GO:0045190)	2.25325325
99	calcium ion-dependent exocytosis (GO:0017156)	2.24623177
100	activated T cell proliferation (GO:0050798)	2.24540347

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.35857649
2	VDR_22108803_ChIP-Seq_LS180_Human	3.20884293
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.20084372
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.83181348
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.79755788
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.78517421
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.63705539
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.62342526
9	GATA1_22025678_ChIP-Seq_K562_Human	2.60552603
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.54126681
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.47644366
12	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.42120799
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.31684364
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.16521846
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.06869054
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.01396197
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.96687915
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.93166493
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.89368335
20	IRF1_19129219_ChIP-ChIP_H3396_Human	1.86146727
21	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.80813955
22	EWS_26573619_Chip-Seq_HEK293_Human	1.78011351
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.77356199
24	VDR_23849224_ChIP-Seq_CD4+_Human	1.76267100
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.74953662
26	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.71733070
27	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.68363783
28	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.68179016
29	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.67207045
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.65063987
31	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.65026612
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.60436752
33	IGF1R_20145208_ChIP-Seq_DFB_Human	1.59073536
34	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.55683317
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.54835678
36	P300_19829295_ChIP-Seq_ESCs_Human	1.54067310
37	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.48842728
38	FUS_26573619_Chip-Seq_HEK293_Human	1.47565271
39	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.45468822
40	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.44055490
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.42636408
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.37945890
43	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37072479
44	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37072479
45	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.35506836
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.33396629
47	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.28488657
48	ER_23166858_ChIP-Seq_MCF-7_Human	1.27788982
49	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.24985467
50	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.24874297
51	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.24345500
52	ELK1_19687146_ChIP-ChIP_HELA_Human	1.23405241
53	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.23189752
54	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.21711478
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21482801
56	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21482801
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21228321
58	CBP_20019798_ChIP-Seq_JUKART_Human	1.21226408
59	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.21226408
60	AR_20517297_ChIP-Seq_VCAP_Human	1.21001641
61	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.20924853
62	TAF15_26573619_Chip-Seq_HEK293_Human	1.19854581
63	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.19714281
64	FOXP3_21729870_ChIP-Seq_TREG_Human	1.19233433
65	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.18157092
66	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16776891
67	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.15402279
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14806967
69	REST_21632747_ChIP-Seq_MESCs_Mouse	1.14556446
70	SMAD4_21799915_ChIP-Seq_A2780_Human	1.12420551
71	MYC_19829295_ChIP-Seq_ESCs_Human	1.10566829
72	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.10475521
73	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.08596902
74	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08236808
75	NCOR_22424771_ChIP-Seq_293T_Human	1.06850501
76	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06828206
77	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.06752568
78	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.05354852
79	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03874895
80	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.02925468
81	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02078304
82	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.02023621
83	STAT3_23295773_ChIP-Seq_U87_Human	1.01992438
84	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01849309
85	AR_25329375_ChIP-Seq_VCAP_Human	1.00861405
86	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.00473495
87	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.99505096
88	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.97246973
89	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.93619227
90	NANOG_20526341_ChIP-Seq_ESCs_Human	0.93618757
91	TCF4_22108803_ChIP-Seq_LS180_Human	0.93503641
92	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.93469898
93	HTT_18923047_ChIP-ChIP_STHdh_Human	0.93448689
94	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.92986954
95	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.92634360
96	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.91286956
97	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.91231940
98	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.91097357
99	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.90637261
100	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.90384956

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.05772806
2	MP0002837_dystrophic_cardiac_calcinosis	3.01131547
3	MP0002163_abnormal_gland_morphology	2.79326369
4	MP0002102_abnormal_ear_morphology	2.77029567
5	MP0000372_irregular_coat_pigmentation	2.50720102
6	MP0004147_increased_porphyrin_level	2.48761217
7	MP0006072_abnormal_retinal_apoptosis	2.44680010
8	MP0006292_abnormal_olfactory_placode	2.41920328
9	MP0003195_calcinosis	2.37703436
10	MP0005671_abnormal_response_to	2.29264917
11	MP0003136_yellow_coat_color	2.18239716
12	MP0004142_abnormal_muscle_tone	2.17212394
13	MP0005377_hearing/vestibular/ear_phenot	2.12639137
14	MP0003878_abnormal_ear_physiology	2.12639137
15	MP0004145_abnormal_muscle_electrophysio	2.05543538
16	MP0002160_abnormal_reproductive_system	1.98048711
17	MP0003646_muscle_fatigue	1.94032850
18	MP0005551_abnormal_eye_electrophysiolog	1.89547628
19	MP0003011_delayed_dark_adaptation	1.88077950
20	MP0005379_endocrine/exocrine_gland_phen	1.87387231
21	MP0001529_abnormal_vocalization	1.85618847
22	MP0002006_tumorigenesis	1.79621097
23	MP0005389_reproductive_system_phenotype	1.78417362
24	MP0002272_abnormal_nervous_system	1.70123581
25	MP0006276_abnormal_autonomic_nervous	1.69503372
26	MP0002277_abnormal_respiratory_mucosa	1.67823882
27	MP0002876_abnormal_thyroid_physiology	1.64472995
28	MP0003183_abnormal_peptide_metabolism	1.64286808
29	MP0008872_abnormal_physiological_respon	1.61389146
30	MP0009745_abnormal_behavioral_response	1.61269001
31	MP0009046_muscle_twitch	1.59005989
32	MP0001984_abnormal_olfaction	1.56094091
33	MP0004742_abnormal_vestibular_system	1.53353858
34	MP0005084_abnormal_gallbladder_morpholo	1.46096058
35	MP0008877_abnormal_DNA_methylation	1.45483651
36	MP0005646_abnormal_pituitary_gland	1.43933125
37	MP0002166_altered_tumor_susceptibility	1.42149309
38	MP0001790_abnormal_immune_system	1.41923961
39	MP0005387_immune_system_phenotype	1.41923961
40	MP0005253_abnormal_eye_physiology	1.39427591
41	MP0001485_abnormal_pinna_reflex	1.39028296
42	MP0004043_abnormal_pH_regulation	1.37354342
43	MP0001905_abnormal_dopamine_level	1.36211138
44	MP0002693_abnormal_pancreas_physiology	1.36153004
45	MP0001919_abnormal_reproductive_system	1.35783559
46	MP0002653_abnormal_ependyma_morphology	1.34902107
47	MP0002095_abnormal_skin_pigmentation	1.33586093
48	MP0005174_abnormal_tail_pigmentation	1.31266811
49	MP0002822_catalepsy	1.27190473
50	MP0002933_joint_inflammation	1.26124134
51	MP0000685_abnormal_immune_system	1.23567152
52	MP0001188_hyperpigmentation	1.21887636
53	MP0005410_abnormal_fertilization	1.19281553
54	MP0003283_abnormal_digestive_organ	1.16475013
55	MP0000427_abnormal_hair_cycle	1.14155187
56	MP0003866_abnormal_defecation	1.13903606
57	MP0004885_abnormal_endolymph	1.12766144
58	MP0008875_abnormal_xenobiotic_pharmacok	1.12647528
59	MP0000015_abnormal_ear_pigmentation	1.12380447
60	MP0009697_abnormal_copulation	1.10123823
61	MP0002148_abnormal_hypersensitivity_rea	1.07393289
62	MP0001501_abnormal_sleep_pattern	1.04915224
63	MP0000230_abnormal_systemic_arterial	1.01139662
64	MP0002909_abnormal_adrenal_gland	1.00943510
65	MP0001968_abnormal_touch/_nociception	0.96540269
66	MP0002132_abnormal_respiratory_system	0.95450673
67	MP0002733_abnormal_thermal_nociception	0.94559717
68	MP0001440_abnormal_grooming_behavior	0.92151148
69	MP0009785_altered_susceptibility_to	0.89973141
70	MP0002751_abnormal_autonomic_nervous	0.89704033
71	MP0002938_white_spotting	0.89469257
72	MP0003252_abnormal_bile_duct	0.88655046
73	MP0001944_abnormal_pancreas_morphology	0.87287856
74	MP0001970_abnormal_pain_threshold	0.86074094
75	MP0005085_abnormal_gallbladder_physiolo	0.85504870
76	MP0001293_anophthalmia	0.85337361
77	MP0009764_decreased_sensitivity_to	0.84703374
78	MP0002572_abnormal_emotion/affect_behav	0.84278019
79	MP0005636_abnormal_mineral_homeostasis	0.84233987
80	MP0002067_abnormal_sensory_capabilities	0.84094849
81	MP0005083_abnormal_biliary_tract	0.84034236
82	MP0006036_abnormal_mitochondrial_physio	0.83771629
83	MP0002064_seizures	0.83710140
84	MP0005645_abnormal_hypothalamus_physiol	0.82296885
85	MP0005075_abnormal_melanosome_morpholog	0.82175718
86	MP0001800_abnormal_humoral_immune	0.80876919
87	MP0002638_abnormal_pupillary_reflex	0.78318644
88	MP0002928_abnormal_bile_duct	0.76526344
89	MP0000631_abnormal_neuroendocrine_gland	0.76176361
90	MP0008775_abnormal_heart_ventricle	0.75970884
91	MP0003693_abnormal_embryo_hatching	0.75846681
92	MP0001486_abnormal_startle_reflex	0.74912835
93	MP0003635_abnormal_synaptic_transmissio	0.74891168
94	MP0001835_abnormal_antigen_presentation	0.73610281
95	MP0006035_abnormal_mitochondrial_morpho	0.73316474
96	MP0001986_abnormal_taste_sensitivity	0.72431461
97	MP0010386_abnormal_urinary_bladder	0.71760481
98	MP0002210_abnormal_sex_determination	0.71103002
99	MP0002075_abnormal_coat/hair_pigmentati	0.70934286
100	MP0005195_abnormal_posterior_eye	0.70253973

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.94089256
2	Thyroiditis (HP:0100646)	3.70898158
3	Hypoproteinemia (HP:0003075)	3.64378572
4	Progressive macrocephaly (HP:0004481)	3.60761960
5	Large for gestational age (HP:0001520)	3.45350381
6	T lymphocytopenia (HP:0005403)	3.39275007
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.33258748
8	Mitochondrial inheritance (HP:0001427)	3.32653275
9	Severe combined immunodeficiency (HP:0004430)	3.31386041
10	Acute encephalopathy (HP:0006846)	3.26535033
11	Abnormality of alanine metabolism (HP:0010916)	3.16531364
12	Hyperalaninemia (HP:0003348)	3.16531364
13	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.16531364
14	IgG deficiency (HP:0004315)	3.14284661
15	B lymphocytopenia (HP:0010976)	3.07838732
16	Abnormality of T cell number (HP:0011839)	3.04319906
17	Pancreatic cysts (HP:0001737)	3.00375319
18	Stomatitis (HP:0010280)	3.00265452
19	Abnormality of B cell number (HP:0010975)	2.99257874
20	Increased CSF lactate (HP:0002490)	2.96785872
21	Congenital, generalized hypertrichosis (HP:0004540)	2.77794792
22	Ketoacidosis (HP:0001993)	2.75606589
23	Panhypogammaglobulinemia (HP:0003139)	2.75118169
24	Conjunctival hamartoma (HP:0100780)	2.72084031
25	Pancreatic fibrosis (HP:0100732)	2.67114698
26	Methylmalonic acidemia (HP:0002912)	2.65383330
27	Neuroendocrine neoplasm (HP:0100634)	2.64711696
28	Hepatic necrosis (HP:0002605)	2.62635907
29	Hypoplasia of the thymus (HP:0000778)	2.61102656
30	Optic disc pallor (HP:0000543)	2.61025781
31	Molar tooth sign on MRI (HP:0002419)	2.57483546
32	Abnormality of midbrain morphology (HP:0002418)	2.57483546
33	Attenuation of retinal blood vessels (HP:0007843)	2.54086094
34	Furrowed tongue (HP:0000221)	2.53548260
35	Methylmalonic aciduria (HP:0012120)	2.53244645
36	Albinism (HP:0001022)	2.52420385
37	Medial flaring of the eyebrow (HP:0010747)	2.48548709
38	Combined immunodeficiency (HP:0005387)	2.43945312
39	Hypoglycemic coma (HP:0001325)	2.38682169
40	Hepatocellular necrosis (HP:0001404)	2.38143483
41	Lipid accumulation in hepatocytes (HP:0006561)	2.37968892
42	Pheochromocytoma (HP:0002666)	2.31714964
43	Neoplasm of the adrenal gland (HP:0100631)	2.28835072
44	Increased hepatocellular lipid droplets (HP:0006565)	2.28571857
45	3-Methylglutaconic aciduria (HP:0003535)	2.27220547
46	Abnormality of T cells (HP:0002843)	2.24512284
47	Gaze-evoked nystagmus (HP:0000640)	2.20871626
48	Rib fusion (HP:0000902)	2.20630532
49	Abnormality of the labia minora (HP:0012880)	2.20168619
50	True hermaphroditism (HP:0010459)	2.19160195
51	Carpal bone hypoplasia (HP:0001498)	2.19044121
52	Congenital stationary night blindness (HP:0007642)	2.18659168
53	Progressive cerebellar ataxia (HP:0002073)	2.18225207
54	Hypothermia (HP:0002045)	2.17545729
55	Cerebral edema (HP:0002181)	2.16591547
56	Gait imbalance (HP:0002141)	2.12682113
57	Abnormality of the renal cortex (HP:0011035)	2.12486352
58	Colon cancer (HP:0003003)	2.09360657
59	Hamartoma of the eye (HP:0010568)	2.06688341
60	Type II lissencephaly (HP:0007260)	2.04745258
61	Nephronophthisis (HP:0000090)	2.04668668
62	Abnormal rod and cone electroretinograms (HP:0008323)	2.04427196
63	Abnormality of the pons (HP:0007361)	2.04344503
64	Congenital primary aphakia (HP:0007707)	2.00849558
65	Increased IgM level (HP:0003496)	1.98168060
66	Hyperinsulinemic hypoglycemia (HP:0000825)	1.96124350
67	Recurrent bronchitis (HP:0002837)	1.93404471
68	Palpebral edema (HP:0100540)	1.92784651
69	Ketosis (HP:0001946)	1.92382137
70	Hypoplasia of the pons (HP:0012110)	1.91230302
71	Respiratory failure (HP:0002878)	1.89827174
72	Pendular nystagmus (HP:0012043)	1.89335910
73	Dicarboxylic aciduria (HP:0003215)	1.89161362
74	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.89161362
75	Lethargy (HP:0001254)	1.88300701
76	Erythroderma (HP:0001019)	1.86134501
77	Eosinophilia (HP:0001880)	1.86066642
78	Tinnitus (HP:0000360)	1.84381005
79	Renal Fanconi syndrome (HP:0001994)	1.84044112
80	Increased serum lactate (HP:0002151)	1.82946833
81	Hypoglycemic seizures (HP:0002173)	1.82796225
82	Nephrogenic diabetes insipidus (HP:0009806)	1.82497888
83	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.81310349
84	Abnormal drinking behavior (HP:0030082)	1.81098341
85	Polydipsia (HP:0001959)	1.81098341
86	Adrenal hypoplasia (HP:0000835)	1.80618926
87	Absent thumb (HP:0009777)	1.79427187
88	Short tibia (HP:0005736)	1.79254260
89	Lactic acidosis (HP:0003128)	1.78951432
90	Abnormality of eosinophils (HP:0001879)	1.77065246
91	Exertional dyspnea (HP:0002875)	1.76672405
92	Agitation (HP:0000713)	1.76284303
93	J-shaped sella turcica (HP:0002680)	1.76196217
94	Recurrent fungal infections (HP:0002841)	1.75898432
95	Tubular atrophy (HP:0000092)	1.75069976
96	Palpitations (HP:0001962)	1.74550651
97	Abnormality of the renal medulla (HP:0100957)	1.71289640
98	Renal cortical cysts (HP:0000803)	1.69171770
99	Abnormality of urine glucose concentration (HP:0011016)	1.67596544
100	Glycosuria (HP:0003076)	1.67596544

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	4.20995493
2	TXK	3.97114869
3	FRK	3.59555921
4	TAOK3	2.85459645
5	ADRBK2	2.83905195
6	NUAK1	2.66897659
7	STK16	2.51976293
8	IRAK4	2.49616284
9	VRK2	2.42177664
10	BMPR1B	2.28342081
11	CAMKK2	2.12698714
12	GRK7	2.05189347
13	MAP4K2	1.96364312
14	TSSK6	1.86090456
15	PINK1	1.68706369
16	EIF2AK3	1.65922127
17	WNK3	1.56344815
18	GRK1	1.55805073
19	ACVR1B	1.46082481
20	TNIK	1.30335427
21	VRK1	1.26393264
22	PASK	1.24191989
23	STK39	1.22829004
24	PLK3	1.22256897
25	NEK1	1.17287990
26	PAK3	1.15676953
27	ADRBK1	1.09951185
28	GRK5	1.07825354
29	PRKCQ	1.07488697
30	MST4	1.06821645
31	MAP3K4	1.05395129
32	MAP3K12	1.02892051
33	MATK	1.02650397
34	BCKDK	1.02164330
35	PLK2	1.00283226
36	TAF1	0.99207680
37	PIK3CA	0.99195584
38	TRIM28	0.98939921
39	PHKG2	0.98621472
40	PHKG1	0.98621472
41	TLK1	0.96743630
42	OXSR1	0.95931439
43	MAP3K11	0.94644753
44	TGFBR1	0.92913844
45	RPS6KA5	0.91315991
46	DYRK2	0.90617630
47	MAP4K1	0.88341837
48	MAP2K7	0.80521729
49	PRKCG	0.80433306
50	CAMKK1	0.77903256
51	ITK	0.76702745
52	MAPK13	0.75391576
53	INSRR	0.74674592
54	TNK2	0.74101807
55	STK3	0.73549199
56	TGFBR2	0.73112918
57	CDK3	0.71046878
58	EIF2AK2	0.70398018
59	NLK	0.69124108
60	WNK4	0.64570095
61	DMPK	0.64392805
62	SYK	0.63747945
63	PRKCE	0.62210180
64	IRAK1	0.61161699
65	CAMK2A	0.61111964
66	STK24	0.60998132
67	TYRO3	0.58862768
68	KDR	0.56316934
69	MKNK1	0.55170086
70	MAP2K6	0.54914138
71	EIF2AK1	0.53977287
72	FGFR2	0.52500739
73	BUB1	0.51637240
74	PRKACA	0.51172867
75	IKBKB	0.50225675
76	CASK	0.49785992
77	MARK1	0.49566431
78	CSNK1A1	0.49397111
79	PLK4	0.45569970
80	MKNK2	0.44676074
81	CAMK1	0.44334784
82	SRPK1	0.43986473
83	FES	0.43259792
84	PRKCA	0.43241114
85	PLK1	0.43231753
86	NEK9	0.43185644
87	CSNK1E	0.42839089
88	PRKG1	0.41365893
89	CSNK1G2	0.41200227
90	MYLK	0.41072242
91	STK38L	0.40570200
92	LCK	0.40506306
93	DYRK1A	0.40386060
94	STK11	0.39988157
95	BLK	0.38421158
96	AURKA	0.36351701
97	ATM	0.35107623
98	PRKCZ	0.34635240
99	LYN	0.34449079
100	CDC7	0.32134730

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.53422686
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.48790803
3	Primary immunodeficiency_Homo sapiens_hsa05340	3.00881505
4	Parkinsons disease_Homo sapiens_hsa05012	2.90373840
5	Proteasome_Homo sapiens_hsa03050	2.87838036
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.54220975
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.15021514
8	Butanoate metabolism_Homo sapiens_hsa00650	2.08230750
9	Ribosome_Homo sapiens_hsa03010	2.03294219
10	Non-homologous end-joining_Homo sapiens_hsa03450	2.01145779
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.97535940
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.93364074
13	RNA degradation_Homo sapiens_hsa03018	1.86320072
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.85280946
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.79948781
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.77720981
17	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.74886015
18	Alzheimers disease_Homo sapiens_hsa05010	1.74307130
19	Regulation of autophagy_Homo sapiens_hsa04140	1.73839767
20	Huntingtons disease_Homo sapiens_hsa05016	1.71387335
21	Phototransduction_Homo sapiens_hsa04744	1.60171909
22	Graft-versus-host disease_Homo sapiens_hsa05332	1.49800090
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.48484893
24	Type I diabetes mellitus_Homo sapiens_hsa04940	1.46031407
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.45856020
26	Cardiac muscle contraction_Homo sapiens_hsa04260	1.40238109
27	Homologous recombination_Homo sapiens_hsa03440	1.39862816
28	RNA polymerase_Homo sapiens_hsa03020	1.39740308
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.37798904
30	Nicotine addiction_Homo sapiens_hsa05033	1.36118453
31	Basal transcription factors_Homo sapiens_hsa03022	1.34878548
32	Collecting duct acid secretion_Homo sapiens_hsa04966	1.34053797
33	Sulfur metabolism_Homo sapiens_hsa00920	1.33496283
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.33325610
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.30872622
36	Insulin secretion_Homo sapiens_hsa04911	1.29365977
37	Antigen processing and presentation_Homo sapiens_hsa04612	1.28333631
38	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.27126317
39	One carbon pool by folate_Homo sapiens_hsa00670	1.25473470
40	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.23615937
41	Ether lipid metabolism_Homo sapiens_hsa00565	1.23052785
42	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.20828478
43	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.17096497
44	Propanoate metabolism_Homo sapiens_hsa00640	1.15327300
45	Tryptophan metabolism_Homo sapiens_hsa00380	1.13280982
46	Allograft rejection_Homo sapiens_hsa05330	1.12905539
47	Peroxisome_Homo sapiens_hsa04146	1.08091816
48	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.06026731
49	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.05868814
50	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.03066792
51	Rheumatoid arthritis_Homo sapiens_hsa05323	0.96994024
52	Caffeine metabolism_Homo sapiens_hsa00232	0.96561738
53	ABC transporters_Homo sapiens_hsa02010	0.92694306
54	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.90289829
55	Steroid biosynthesis_Homo sapiens_hsa00100	0.88870071
56	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.87418813
57	Asthma_Homo sapiens_hsa05310	0.86533689
58	Taste transduction_Homo sapiens_hsa04742	0.84688033
59	Morphine addiction_Homo sapiens_hsa05032	0.84443673
60	Purine metabolism_Homo sapiens_hsa00230	0.82874537
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.78926392
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.77975570
63	Mismatch repair_Homo sapiens_hsa03430	0.75083628
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.72335577
65	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.69439965
66	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.67237731
67	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.66910517
68	RNA transport_Homo sapiens_hsa03013	0.65070188
69	GABAergic synapse_Homo sapiens_hsa04727	0.61556390
70	Metabolic pathways_Homo sapiens_hsa01100	0.58730801
71	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.58094966
72	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.57010815
73	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.56876559
74	Olfactory transduction_Homo sapiens_hsa04740	0.56377476
75	Fanconi anemia pathway_Homo sapiens_hsa03460	0.55512571
76	Retinol metabolism_Homo sapiens_hsa00830	0.54500348
77	Type II diabetes mellitus_Homo sapiens_hsa04930	0.54433299
78	Glutamatergic synapse_Homo sapiens_hsa04724	0.53081696
79	Chemical carcinogenesis_Homo sapiens_hsa05204	0.50593932
80	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.49913919
81	Pyrimidine metabolism_Homo sapiens_hsa00240	0.48018197
82	Nucleotide excision repair_Homo sapiens_hsa03420	0.47551448
83	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.46616630
84	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.46036386
85	Mineral absorption_Homo sapiens_hsa04978	0.45004905
86	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.44520241
87	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.43721173
88	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.42760038
89	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.41072241
90	Sulfur relay system_Homo sapiens_hsa04122	0.36219036
91	Serotonergic synapse_Homo sapiens_hsa04726	0.35548162
92	Fat digestion and absorption_Homo sapiens_hsa04975	0.33360307
93	Circadian entrainment_Homo sapiens_hsa04713	0.31693014
94	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.31296983
95	Cocaine addiction_Homo sapiens_hsa05030	0.30275578
96	Salivary secretion_Homo sapiens_hsa04970	0.29649687
97	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.29466812
98	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.25982710
99	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.25782130
100	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.24355691

THRAP3P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »