THRB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurotransmitter-gated ion channel clustering (GO:0072578)5.91114019
2presynaptic membrane assembly (GO:0097105)5.42462505
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.30699331
4synaptic vesicle maturation (GO:0016188)5.03274001
5presynaptic membrane organization (GO:0097090)4.89523887
6regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.76230602
7negative regulation of synaptic transmission, GABAergic (GO:0032229)4.67872406
8vocalization behavior (GO:0071625)4.51880529
9neuron cell-cell adhesion (GO:0007158)4.45763126
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.43459358
11postsynaptic membrane organization (GO:0001941)4.42923503
12glutamate secretion (GO:0014047)4.37465260
13synaptic vesicle exocytosis (GO:0016079)4.25902737
14regulation of short-term neuronal synaptic plasticity (GO:0048172)4.16455894
15cellular potassium ion homeostasis (GO:0030007)4.14447701
16regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.01640778
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.99099922
18regulation of synaptic vesicle exocytosis (GO:2000300)3.91095155
19protein localization to synapse (GO:0035418)3.89440212
20regulation of glutamate receptor signaling pathway (GO:1900449)3.89149647
21membrane depolarization during action potential (GO:0086010)3.67965984
22neurotransmitter secretion (GO:0007269)3.67291387
23response to histamine (GO:0034776)3.63517082
24long-term synaptic potentiation (GO:0060291)3.54410137
25startle response (GO:0001964)3.50992345
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.49609048
27cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.47937780
28NADH metabolic process (GO:0006734)3.45286774
29regulation of synaptic vesicle transport (GO:1902803)3.43441991
30succinate metabolic process (GO:0006105)3.42224197
31cerebellar granule cell differentiation (GO:0021707)3.42085668
32oxaloacetate metabolic process (GO:0006107)3.41313594
33neuron-neuron synaptic transmission (GO:0007270)3.36474959
34positive regulation of neurotransmitter secretion (GO:0001956)3.34067626
35gamma-aminobutyric acid transport (GO:0015812)3.29787766
36serotonin metabolic process (GO:0042428)3.24372787
37negative regulation of cytosolic calcium ion concentration (GO:0051481)3.22657676
38cellular sodium ion homeostasis (GO:0006883)3.22060588
39transferrin transport (GO:0033572)3.20149534
40positive regulation of neurotransmitter transport (GO:0051590)3.19613671
41behavioral response to cocaine (GO:0048148)3.19490038
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.17424287
43potassium ion import (GO:0010107)3.14664414
44negative regulation of dendrite morphogenesis (GO:0050774)3.13944350
45mechanosensory behavior (GO:0007638)3.13861953
46synaptic transmission, glutamatergic (GO:0035249)3.11566462
47detection of calcium ion (GO:0005513)3.10778994
48cardiac conduction (GO:0061337)3.10430001
49energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.09126225
50ATP hydrolysis coupled proton transport (GO:0015991)3.09126225
51ionotropic glutamate receptor signaling pathway (GO:0035235)3.06883553
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.06061774
53trivalent inorganic cation transport (GO:0072512)3.05030092
54ferric iron transport (GO:0015682)3.05030092
55positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.04643944
56regulation of sodium ion transmembrane transporter activity (GO:2000649)3.03924045
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.02179742
58positive regulation of potassium ion transmembrane transport (GO:1901381)3.01839983
59glutamate receptor signaling pathway (GO:0007215)3.01079177
60positive regulation of synapse maturation (GO:0090129)3.00931878
61dicarboxylic acid catabolic process (GO:0043649)3.00547873
62potassium ion homeostasis (GO:0055075)2.96964448
63regulation of excitatory postsynaptic membrane potential (GO:0060079)2.95910124
64sodium ion export (GO:0071436)2.95380780
65locomotory exploration behavior (GO:0035641)2.91728344
66cell communication by electrical coupling (GO:0010644)2.91021215
67regulation of heart rate by cardiac conduction (GO:0086091)2.90988789
68positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.89188848
69positive regulation of synapse assembly (GO:0051965)2.85454684
70neurotransmitter transport (GO:0006836)2.83875812
71regulation of membrane repolarization (GO:0060306)2.83757198
72negative regulation of appetite (GO:0032099)2.83519350
73negative regulation of response to food (GO:0032096)2.83519350
74regulation of postsynaptic membrane potential (GO:0060078)2.82015167
75regulation of glutamate secretion (GO:0014048)2.81861014
76multicellular organismal signaling (GO:0035637)2.81731137
77regulation of voltage-gated calcium channel activity (GO:1901385)2.80160739
78negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.78949215
79cardiac muscle cell action potential involved in contraction (GO:0086002)2.78508987
80action potential (GO:0001508)2.77743301
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.76864884
82L-phenylalanine catabolic process (GO:0006559)2.75744245
83erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.75744245
84cardiac muscle cell action potential (GO:0086001)2.75571525
85regulation of cell communication by electrical coupling (GO:0010649)2.75549031
86neuronal action potential propagation (GO:0019227)2.75044016
87coenzyme catabolic process (GO:0009109)2.74715852
88cellular ketone body metabolic process (GO:0046950)2.74571937
89central nervous system myelination (GO:0022010)2.74528910
90axon ensheathment in central nervous system (GO:0032291)2.74528910
91G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.74381284
92L-amino acid import (GO:0043092)2.71277772
93regulation of neurotransmitter secretion (GO:0046928)2.71218577
94* regulation of female receptivity (GO:0045924)2.69880247
95regulation of synapse maturation (GO:0090128)2.69230119
96regulation of sodium ion transmembrane transport (GO:1902305)2.68924422
97regulation of neurotransmitter levels (GO:0001505)2.68387595
98positive regulation of synaptic transmission (GO:0050806)2.68329916
99neuronal action potential (GO:0019228)2.67559170
100negative regulation of dendrite development (GO:2000171)2.67058584
101positive regulation of membrane potential (GO:0045838)2.66868206
102positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.66448098
103transmission of nerve impulse (GO:0019226)2.66088040
104behavioral response to nicotine (GO:0035095)2.66028402
105positive regulation of sodium ion transport (GO:0010765)2.65657636
106regulation of calcium ion-dependent exocytosis (GO:0017158)2.65156293
107glutamate metabolic process (GO:0006536)2.64204273
108dicarboxylic acid biosynthetic process (GO:0043650)2.62960690
109tricarboxylic acid cycle (GO:0006099)2.60480614
110positive regulation of cardiac muscle hypertrophy (GO:0010613)2.58982512
111positive regulation of muscle hypertrophy (GO:0014742)2.58982512
112regulation of synaptic plasticity (GO:0048167)2.58974132
113membrane depolarization (GO:0051899)2.58424490
114behavioral defense response (GO:0002209)2.57037842
115behavioral fear response (GO:0001662)2.57037842
116auditory behavior (GO:0031223)2.56837959
117aromatic amino acid family catabolic process (GO:0009074)2.55226588
118proline transport (GO:0015824)2.53892991
119regulation of acyl-CoA biosynthetic process (GO:0050812)2.53815221
120regulation of synaptic transmission, GABAergic (GO:0032228)2.52736332
121relaxation of cardiac muscle (GO:0055119)2.51699138
122positive regulation of potassium ion transport (GO:0043268)2.51025626
123high-density lipoprotein particle remodeling (GO:0034375)2.50142563
124cell communication involved in cardiac conduction (GO:0086065)2.49470129
125aspartate family amino acid catabolic process (GO:0009068)2.48169982
126erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.47967310
127L-phenylalanine metabolic process (GO:0006558)2.47967310
128fear response (GO:0042596)2.47836826
129cellular response to ammonium ion (GO:0071242)2.47149425
130positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.47107828
131regulation of long-term neuronal synaptic plasticity (GO:0048169)2.46505765
132relaxation of muscle (GO:0090075)2.45826626
133regulation of neuronal synaptic plasticity (GO:0048168)2.45152291
134negative regulation of protein localization to cell surface (GO:2000009)2.44885849
135striatum development (GO:0021756)2.44726380
136membrane repolarization (GO:0086009)2.43929632
137regulation of neurotransmitter transport (GO:0051588)2.43770347
138sleep (GO:0030431)2.43354008
139calcium ion-dependent exocytosis (GO:0017156)2.43303887
140membrane assembly (GO:0071709)2.43131814
141neuromuscular synaptic transmission (GO:0007274)2.42951012
142cerebellar Purkinje cell differentiation (GO:0021702)2.42824357
143indole-containing compound catabolic process (GO:0042436)2.42703952
144indolalkylamine catabolic process (GO:0046218)2.42703952
145tryptophan catabolic process (GO:0006569)2.42703952
146neurotransmitter uptake (GO:0001504)2.42558325
147triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.41843081
148bile acid biosynthetic process (GO:0006699)2.41684724
149synapse assembly (GO:0007416)2.40621952
150primary amino compound metabolic process (GO:1901160)2.40387690
151positive regulation of dendritic spine development (GO:0060999)2.39905608
152membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.39565539
153regulation of amino acid transport (GO:0051955)2.38126382
154sodium ion homeostasis (GO:0055078)2.37798276
155regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.36780468
156adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.36648514
157retinal cone cell development (GO:0046549)2.36290788

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.74393325
2EZH2_22144423_ChIP-Seq_EOC_Human4.01715779
3TAF15_26573619_Chip-Seq_HEK293_Human3.03174575
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.73780437
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60031331
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.53418667
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.35538323
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28925716
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26009609
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21410312
11* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17622124
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10874524
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09319957
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08425440
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.03456295
16RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99045806
17EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99045806
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98179751
19REST_21632747_ChIP-Seq_MESCs_Mouse1.97564410
20* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96450251
21* EZH2_27304074_Chip-Seq_ESCs_Mouse1.95757314
22* P300_19829295_ChIP-Seq_ESCs_Human1.94662559
23* SMAD4_21799915_ChIP-Seq_A2780_Human1.90672158
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.89902668
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89437470
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88704031
27* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.83109576
28* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79572103
29AR_21572438_ChIP-Seq_LNCaP_Human1.75549522
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.73448112
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71929141
32* PIAS1_25552417_ChIP-Seq_VCAP_Human1.71492885
33FUS_26573619_Chip-Seq_HEK293_Human1.69802047
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.68675953
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66403390
36VDR_22108803_ChIP-Seq_LS180_Human1.66370914
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60907471
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.59671746
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59615286
40AR_25329375_ChIP-Seq_VCAP_Human1.58560525
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58285461
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.57227819
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.51447961
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51374427
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.50121691
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47740054
47* RNF2_27304074_Chip-Seq_ESCs_Mouse1.47532495
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46973478
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41453467
50* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41392665
51DROSHA_22980978_ChIP-Seq_HELA_Human1.39297850
52* SOX2_21211035_ChIP-Seq_LN229_Gbm1.38402981
53ER_23166858_ChIP-Seq_MCF-7_Human1.37155531
54RXR_22158963_ChIP-Seq_LIVER_Mouse1.36729663
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36726499
56* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35490681
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.34147273
58* STAT3_23295773_ChIP-Seq_U87_Human1.29418045
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27638746
60TCF4_23295773_ChIP-Seq_U87_Human1.27164769
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24947883
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22857049
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.22401532
64* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21625029
65* LXR_22158963_ChIP-Seq_LIVER_Mouse1.21081705
66* ARNT_22903824_ChIP-Seq_MCF-7_Human1.21028040
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.20252576
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.18674975
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18427627
70* RNF2_27304074_Chip-Seq_NSC_Mouse1.18042377
71* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16934112
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16425353
73RUNX2_22187159_ChIP-Seq_PCA_Human1.15348431
74ESR1_21235772_ChIP-Seq_MCF-7_Human1.14526763
75CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14515193
76BCAT_22108803_ChIP-Seq_LS180_Human1.13938433
77* AHR_22903824_ChIP-Seq_MCF-7_Human1.13926894
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13684007
79EP300_21415370_ChIP-Seq_HL-1_Mouse1.12842637
80HTT_18923047_ChIP-ChIP_STHdh_Human1.12272741
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12155395
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10952751
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10648313
84P53_22387025_ChIP-Seq_ESCs_Mouse1.10247835
85* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09886372
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09400399
87KDM2B_26808549_Chip-Seq_REH_Human1.09298498
88E2F1_18555785_Chip-Seq_ESCs_Mouse1.08984758
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07435632
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07166413
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06918776
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06691456
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06691456
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06533143
95PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06085745
96CBP_20019798_ChIP-Seq_JUKART_Human1.05147298
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05147298
98RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04513259
99* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03123203
100* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02713192
101RING1B_27294783_Chip-Seq_ESCs_Mouse1.02288850
102WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01413759
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00282114
104SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99756690
105* TP53_18474530_ChIP-ChIP_U2OS_Human0.99528319
106MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99342455
107PRDM14_20953172_ChIP-Seq_ESCs_Human0.99296474
108SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99253863
109FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99196356
110* AR_19668381_ChIP-Seq_PC3_Human0.98559763
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98509376
112SOX2_18555785_Chip-Seq_ESCs_Mouse0.98383455
113CMYC_18555785_Chip-Seq_ESCs_Mouse0.98101752
114IGF1R_20145208_ChIP-Seq_DFB_Human0.95635557
115* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92774360
116EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92287962
117SMAD3_21741376_ChIP-Seq_HESCs_Human0.89935422
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.89071828
119LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88209979
120TP53_16413492_ChIP-PET_HCT116_Human0.87809810
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87786498
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87311811
123SMAD4_21741376_ChIP-Seq_HESCs_Human0.86835803
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86153979

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.48597885
2MP0004859_abnormal_synaptic_plasticity3.61980218
3MP0002139_abnormal_hepatobiliary_system3.20516674
4MP0009745_abnormal_behavioral_response3.09066010
5MP0003635_abnormal_synaptic_transmissio3.02258375
6MP0001968_abnormal_touch/_nociception2.98249219
7MP0002736_abnormal_nociception_after2.91853262
8MP0009046_muscle_twitch2.78444965
9MP0008875_abnormal_xenobiotic_pharmacok2.70301592
10* MP0002064_seizures2.67749668
11MP0005365_abnormal_bile_salt2.65504934
12* MP0002063_abnormal_learning/memory/cond2.64451262
13MP0005360_urolithiasis2.61224101
14MP0005085_abnormal_gallbladder_physiolo2.56549841
15MP0002822_catalepsy2.54006055
16MP0002572_abnormal_emotion/affect_behav2.49762415
17* MP0002876_abnormal_thyroid_physiology2.45391065
18MP0004270_analgesia2.29300970
19MP0001501_abnormal_sleep_pattern2.11159856
20MP0002837_dystrophic_cardiac_calcinosis2.10657429
21MP0004145_abnormal_muscle_electrophysio2.06867884
22* MP0002272_abnormal_nervous_system2.04520164
23MP0002734_abnormal_mechanical_nocicepti2.04193965
24MP0001440_abnormal_grooming_behavior2.00658759
25MP0002735_abnormal_chemical_nociception1.96812320
26MP0003183_abnormal_peptide_metabolism1.96164651
27MP0001486_abnormal_startle_reflex1.94504979
28* MP0005646_abnormal_pituitary_gland1.94426562
29* MP0004130_abnormal_muscle_cell1.90134905
30MP0002067_abnormal_sensory_capabilities1.89603978
31MP0010329_abnormal_lipoprotein_level1.85011729
32MP0005670_abnormal_white_adipose1.68049067
33MP0006276_abnormal_autonomic_nervous1.62874894
34MP0003787_abnormal_imprinting1.59776099
35* MP0005551_abnormal_eye_electrophysiolog1.56163187
36MP0004924_abnormal_behavior1.49734635
37MP0005386_behavior/neurological_phenoty1.49734635
38MP0002557_abnormal_social/conspecific_i1.48923387
39MP0003195_calcinosis1.47229343
40MP0001984_abnormal_olfaction1.45047244
41MP0001188_hyperpigmentation1.40936183
42MP0001502_abnormal_circadian_rhythm1.40407642
43MP0005645_abnormal_hypothalamus_physiol1.39541633
44MP0004036_abnormal_muscle_relaxation1.36655185
45MP0004043_abnormal_pH_regulation1.29994698
46* MP0003879_abnormal_hair_cell1.29666510
47MP0001485_abnormal_pinna_reflex1.27864911
48MP0002909_abnormal_adrenal_gland1.25684955
49MP0001970_abnormal_pain_threshold1.25530774
50MP0004142_abnormal_muscle_tone1.22449716
51MP0005332_abnormal_amino_acid1.20260130
52MP0001764_abnormal_homeostasis1.17834810
53MP0002733_abnormal_thermal_nociception1.17579150
54MP0004215_abnormal_myocardial_fiber1.16381412
55MP0003633_abnormal_nervous_system1.15785757
56MP0003011_delayed_dark_adaptation1.14037032
57MP0008775_abnormal_heart_ventricle1.13470773
58MP0008569_lethality_at_weaning1.10610376
59MP0005535_abnormal_body_temperature1.10434312
60MP0008004_abnormal_stomach_pH1.10337141
61MP0003252_abnormal_bile_duct1.10059978
62MP0003690_abnormal_glial_cell1.09245999
63MP0003329_amyloid_beta_deposits1.05986435
64MP0001765_abnormal_ion_homeostasis1.05703206
65MP0002066_abnormal_motor_capabilities/c1.02859786
66MP0004147_increased_porphyrin_level1.00108176
67* MP0009780_abnormal_chondrocyte_physiolo0.99040107
68MP0002160_abnormal_reproductive_system0.98282995
69MP0001529_abnormal_vocalization0.98240740
70MP0002069_abnormal_eating/drinking_beha0.97943328
71MP0008872_abnormal_physiological_respon0.96596651
72MP0002184_abnormal_innervation0.96205092
73MP0001905_abnormal_dopamine_level0.95201065
74MP0002118_abnormal_lipid_homeostasis0.95002345
75MP0009697_abnormal_copulation0.94918516
76MP0000751_myopathy0.94094309
77MP0004019_abnormal_vitamin_homeostasis0.93084931
78MP0005167_abnormal_blood-brain_barrier0.92445523
79MP0002638_abnormal_pupillary_reflex0.91416028
80MP0001664_abnormal_digestion0.91112175
81* MP0000631_abnormal_neuroendocrine_gland0.90268887
82MP0003646_muscle_fatigue0.90209424
83* MP0001963_abnormal_hearing_physiology0.89993946
84MP0006292_abnormal_olfactory_placode0.89653423
85MP0000013_abnormal_adipose_tissue0.89471649
86MP0004084_abnormal_cardiac_muscle0.89377558
87MP0005187_abnormal_penis_morphology0.89275155
88* MP0002882_abnormal_neuron_morphology0.89162402
89MP0003631_nervous_system_phenotype0.88676391
90MP0008874_decreased_physiological_sensi0.87874049
91MP0004811_abnormal_neuron_physiology0.86870538
92MP0000778_abnormal_nervous_system0.85167641
93* MP0002229_neurodegeneration0.84213319
94MP0005620_abnormal_muscle_contractility0.83874552
95MP0004510_myositis0.83811268
96MP0005464_abnormal_platelet_physiology0.83436590
97* MP0003638_abnormal_response/metabolism_0.82385620
98MP0004885_abnormal_endolymph0.81884960
99MP0002138_abnormal_hepatobiliary_system0.81827699
100MP0004134_abnormal_chest_morphology0.79794582
101MP0003868_abnormal_feces_composition0.79564447
102MP0005253_abnormal_eye_physiology0.79362218
103MP0005423_abnormal_somatic_nervous0.78773304
104MP0005084_abnormal_gallbladder_morpholo0.78300167
105MP0001666_abnormal_nutrient_absorption0.77986512
106MP0003122_maternal_imprinting0.77907996
107MP0001986_abnormal_taste_sensitivity0.77481798
108MP0006036_abnormal_mitochondrial_physio0.77190757
109MP0002971_abnormal_brown_adipose0.76696655
110MP0005448_abnormal_energy_balance0.76171332
111MP0000955_abnormal_spinal_cord0.75758710
112MP0001756_abnormal_urination0.74891725
113MP0002078_abnormal_glucose_homeostasis0.73203257
114MP0001177_atelectasis0.72959552
115MP0003137_abnormal_impulse_conducting0.72299270
116MP0005636_abnormal_mineral_homeostasis0.71794239
117MP0008877_abnormal_DNA_methylation0.69980145
118MP0004484_altered_response_of0.69792581
119MP0010386_abnormal_urinary_bladder0.68403032
120MP0005647_abnormal_sex_gland0.67690541
121MP0005394_taste/olfaction_phenotype0.66871615
122MP0005499_abnormal_olfactory_system0.66871615
123* MP0004085_abnormal_heartbeat0.66749214
124MP0001542_abnormal_bone_strength0.66717348
125MP0003806_abnormal_nucleotide_metabolis0.65911046
126* MP0000026_abnormal_inner_ear0.65225051
127MP0005584_abnormal_enzyme/coenzyme_acti0.64913083
128MP0000230_abnormal_systemic_arterial0.64839311

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.00791987
2Hyperventilation (HP:0002883)6.92705071
3Epileptic encephalopathy (HP:0200134)5.52875201
4Atonic seizures (HP:0010819)5.16196367
5Febrile seizures (HP:0002373)4.63770981
6Focal seizures (HP:0007359)3.99082803
7Absence seizures (HP:0002121)3.75539142
8Dialeptic seizures (HP:0011146)3.52198787
9Ventricular fibrillation (HP:0001663)3.40341893
10Bundle branch block (HP:0011710)3.28448234
11Abnormality of binocular vision (HP:0011514)3.25425441
12Diplopia (HP:0000651)3.25425441
13Action tremor (HP:0002345)3.24310132
14Generalized tonic-clonic seizures (HP:0002069)3.13584356
15Broad-based gait (HP:0002136)3.11237840
16Pheochromocytoma (HP:0002666)2.99989676
17Blue irides (HP:0000635)2.89575679
18Increased circulating renin level (HP:0000848)2.88134763
19Syncope (HP:0001279)2.84988631
20Dysmetric saccades (HP:0000641)2.80197091
21Abnormal hair whorl (HP:0010721)2.77067256
22Protruding tongue (HP:0010808)2.76249316
23Progressive cerebellar ataxia (HP:0002073)2.70969638
24Epileptiform EEG discharges (HP:0011182)2.69441819
25Oligomenorrhea (HP:0000876)2.68744272
26Visual hallucinations (HP:0002367)2.65663231
27Neuroendocrine neoplasm (HP:0100634)2.62540506
28Abnormal mitochondria in muscle tissue (HP:0008316)2.58677722
29Decreased central vision (HP:0007663)2.58636626
30Impaired vibration sensation in the lower limbs (HP:0002166)2.56849838
31Hyperlipoproteinemia (HP:0010980)2.55521383
32Gaze-evoked nystagmus (HP:0000640)2.55376256
33Dysdiadochokinesis (HP:0002075)2.52829951
34Gait imbalance (HP:0002141)2.51270039
35Poor suck (HP:0002033)2.48814849
36Fair hair (HP:0002286)2.48170840
37Hemiparesis (HP:0001269)2.47730875
38Acute necrotizing encephalopathy (HP:0006965)2.46642015
39Prolonged partial thromboplastin time (HP:0003645)2.45563378
40Myokymia (HP:0002411)2.45562775
41Abnormal gallbladder physiology (HP:0012438)2.44708322
42Cholecystitis (HP:0001082)2.44708322
43Congenital primary aphakia (HP:0007707)2.42803609
44Medial flaring of the eyebrow (HP:0010747)2.42381546
45Decreased circulating renin level (HP:0003351)2.41700166
46Conjugated hyperbilirubinemia (HP:0002908)2.41381864
47Status epilepticus (HP:0002133)2.39659888
48Acute encephalopathy (HP:0006846)2.39241366
49Muscle fiber inclusion bodies (HP:0100299)2.39037197
50Intrahepatic cholestasis (HP:0001406)2.38608546
51Increased serum pyruvate (HP:0003542)2.38171994
52Abnormality of glycolysis (HP:0004366)2.38171994
53Renal cortical cysts (HP:0000803)2.36587594
54Abnormal social behavior (HP:0012433)2.36554837
55Impaired social interactions (HP:0000735)2.36554837
56Nephrogenic diabetes insipidus (HP:0009806)2.36422398
57Deep venous thrombosis (HP:0002625)2.35676688
58EEG with generalized epileptiform discharges (HP:0011198)2.33648065
59Intention tremor (HP:0002080)2.33277541
60Ankle clonus (HP:0011448)2.33209088
61Drooling (HP:0002307)2.31307653
62Excessive salivation (HP:0003781)2.31307653
63Heart block (HP:0012722)2.31213800
64Abnormal eating behavior (HP:0100738)2.30276662
65Impaired vibratory sensation (HP:0002495)2.30018803
66Poor eye contact (HP:0000817)2.29794200
67Xanthomatosis (HP:0000991)2.29016200
68Progressive macrocephaly (HP:0004481)2.27121673
69Abnormality of aromatic amino acid family metabolism (HP:0004338)2.27042009
70Gout (HP:0001997)2.26661677
71Vascular calcification (HP:0004934)2.25963617
72Polyphagia (HP:0002591)2.25376302
73Narrow nasal bridge (HP:0000446)2.24829073
74Menorrhagia (HP:0000132)2.24054574
75Hyporeflexia of lower limbs (HP:0002600)2.24009980
76Inability to walk (HP:0002540)2.23548533
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21215859
78Abnormality of alanine metabolism (HP:0010916)2.21215859
79Hyperalaninemia (HP:0003348)2.21215859
80Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.19996668
81Spontaneous abortion (HP:0005268)2.18797733
82Hypsarrhythmia (HP:0002521)2.18595961
83Sensorimotor neuropathy (HP:0007141)2.18023129
84Cerebral edema (HP:0002181)2.16001562
85Ketosis (HP:0001946)2.15314049
86Agitation (HP:0000713)2.14499031
87Hyperkalemia (HP:0002153)2.13324615
88Ketoacidosis (HP:0001993)2.13227052
89Torticollis (HP:0000473)2.12522949
90Genetic anticipation (HP:0003743)2.11770592
91Nemaline bodies (HP:0003798)2.11353831
92Hypobetalipoproteinemia (HP:0003563)2.09741708
93Hyperglycinemia (HP:0002154)2.09479809
94Aplasia involving bones of the extremities (HP:0009825)2.08840054
95Aplasia involving bones of the upper limbs (HP:0009823)2.08840054
96Aplasia of the phalanges of the hand (HP:0009802)2.08840054
97Central scotoma (HP:0000603)2.08315585
98Dysmetria (HP:0001310)2.07977302
99Congenital stationary night blindness (HP:0007642)2.07787051
100Urinary bladder sphincter dysfunction (HP:0002839)2.07748313
101Exercise-induced myalgia (HP:0003738)2.07549584
102Sensory axonal neuropathy (HP:0003390)2.07213442
103Abnormality of the nasal septum (HP:0000419)2.05038150
104Abnormal atrioventricular conduction (HP:0005150)2.02182250
105Generalized hypopigmentation of hair (HP:0011358)2.01378904
106Confusion (HP:0001289)2.00940702
107Hypoalphalipoproteinemia (HP:0003233)2.00769255
108Incomplete penetrance (HP:0003829)2.00273331
109Metabolic alkalosis (HP:0200114)1.99775093
110Poor coordination (HP:0002370)1.98650754
111Scanning speech (HP:0002168)1.98426591
112Cardiovascular calcification (HP:0011915)1.96651733
113Resting tremor (HP:0002322)1.96611403
114Abnormal gallbladder morphology (HP:0012437)1.96142377
115Abnormality of renin-angiotensin system (HP:0000847)1.96017049
116Anxiety (HP:0000739)1.95583770
117Muscle hypertrophy of the lower extremities (HP:0008968)1.94877774
118Cholelithiasis (HP:0001081)1.93629920
119Sudden death (HP:0001699)1.93067014
120Abnormality of the renal cortex (HP:0011035)1.92256397
121Truncal ataxia (HP:0002078)1.92175844
122Hypolipoproteinemia (HP:0010981)1.91601808
123Congenital sensorineural hearing impairment (HP:0008527)1.91553798
124Hemiplegia (HP:0002301)1.91215721
125Hepatocellular necrosis (HP:0001404)1.90600441
126Chronic hepatic failure (HP:0100626)1.88917395
127Hyperaldosteronism (HP:0000859)1.86386694
128Abnormal EKG (HP:0003115)1.86293034
129Spastic gait (HP:0002064)1.85877675
130Oligodontia (HP:0000677)1.85187816
131Complement deficiency (HP:0004431)1.85131396
132Optic disc pallor (HP:0000543)1.84057243
133Calf muscle hypertrophy (HP:0008981)1.83255336
134Hyperactive renin-angiotensin system (HP:0000841)1.82028146
135Mitochondrial inheritance (HP:0001427)1.81918969
136Increased CSF lactate (HP:0002490)1.81558604
137Ventricular arrhythmia (HP:0004308)1.81357380
138Limb dystonia (HP:0002451)1.79878561
139Progressive inability to walk (HP:0002505)1.79172987
140Metabolic acidosis (HP:0001942)1.78532055
141Hyperglycinuria (HP:0003108)1.78156112
142Impaired smooth pursuit (HP:0007772)1.78147711
143Papilledema (HP:0001085)1.76502683
144Prolonged bleeding time (HP:0003010)1.76019577
145Focal dystonia (HP:0004373)1.75529969
146Generalized myoclonic seizures (HP:0002123)1.73642326
147Abnormality of potassium homeostasis (HP:0011042)1.73257841
148Cubitus valgus (HP:0002967)1.72641240
149Amblyopia (HP:0000646)1.71956712
150Prolonged QT interval (HP:0001657)1.70298833
151Myotonia (HP:0002486)1.69962359
152Hyperammonemia (HP:0001987)1.69685791
153Hepatic necrosis (HP:0002605)1.69541868
154Abnormality of the lower motor neuron (HP:0002366)1.69538717
155Abnormality of ocular smooth pursuit (HP:0000617)1.69185155
156Abnormality of glycine metabolism (HP:0010895)1.69141593
157Abnormality of serine family amino acid metabolism (HP:0010894)1.69141593
158Failure to thrive in infancy (HP:0001531)1.67886431
159Absent speech (HP:0001344)1.67862845
160Postural instability (HP:0002172)1.67452032
161Osteomalacia (HP:0002749)1.66209144
162Megalencephaly (HP:0001355)1.65785372
163Polydipsia (HP:0001959)1.63122105
164Abnormal drinking behavior (HP:0030082)1.63122105
165Obstructive sleep apnea (HP:0002870)1.61573170
166Craniofacial dystonia (HP:0012179)1.59145748
167Hypomagnesemia (HP:0002917)1.58171393
168Abnormality of the middle phalanges of the toes (HP:0010183)1.57891788
169Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.55683903
170Short 1st metacarpal (HP:0010034)1.55683903
171Absent phalangeal crease (HP:0006109)1.55659868

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK7.75933450
2AKT33.44171258
3MAP2K73.22464399
4DAPK23.17544335
5EPHA42.96766708
6PHKG12.94602992
7NTRK32.85187121
8MAP3K42.76766253
9MAP3K122.60868633
10CCNB12.47182357
11OBSCN2.31561667
12DAPK12.18852966
13PRPF4B2.13823820
14PLK22.09388260
15CDK192.07359980
16MAP2K41.97630125
17SGK21.78905416
18TSSK61.77437040
19SIK31.61149342
20PDK41.55756292
21PDK31.55756292
22INSRR1.53318638
23OXSR11.53026466
24SGK4941.50831499
25SGK2231.50831499
26PRKCG1.46070039
27STK391.44137558
28GRK51.29847762
29SGK31.27082540
30MAP2K61.25776451
31MAPK71.19765672
32PAK31.19513375
33TAOK31.17454085
34MAPKAPK31.16831581
35PDK21.14645524
36CAMKK21.13266192
37MAPK121.12628228
38NTRK11.11756874
39MINK11.10481572
40NTRK21.08231661
41ERBB41.05846613
42WNK41.05340654
43UHMK11.04121497
44CAMK2A1.02517622
45PRKD31.01660275
46PRKCE1.01371640
47TNIK0.92870310
48NME10.91657643
49BMPR20.91457112
50LATS20.90986418
51MYLK0.88414223
52FRK0.86613711
53PIK3CA0.85687171
54MUSK0.85515533
55BRAF0.83433879
56CDK80.81619721
57TLK10.81346295
58PINK10.80666795
59BCKDK0.80072837
60BCR0.79988414
61CDK50.79601526
62ADRBK20.78503095
63NEK60.77346055
64STK380.77269014
65PTK2B0.76569541
66RIPK40.75012571
67TYRO30.74839237
68CAMK2B0.74782332
69MAPK130.73869535
70ADRBK10.69628697
71ERBB20.67499861
72SGK10.66343708
73CAMKK10.63954655
74CDK30.63766802
75MAP3K90.63649947
76KSR10.62282957
77MARK10.61825991
78GRK10.60748248
79PRKG10.60711927
80MAP4K20.60189675
81CAMK1G0.59999355
82SIK10.58827968
83PKN10.58803884
84WNK30.56903180
85DAPK30.54968158
86PRKCZ0.54578183
87DMPK0.54138054
88CAMK2G0.52641975
89MAPKAPK50.52574903
90PRKACG0.51894033
91PRKAA10.50449169
92PAK60.50300597
93YES10.50151964
94FER0.50099977
95TNK20.49753698
96CSNK1G20.49000501
97PRKAA20.48476138
98DYRK1A0.48354403
99RIPK10.48338521
100CAMK2D0.47849708
101MAP3K70.46939613
102CSNK1E0.46600209
103KSR20.45826974
104PIK3CG0.43026972
105PRKCH0.41987571
106CSNK1A10.41085619
107MAPK100.40979619
108PRKACA0.40372145
109CDK180.40016374
110CAMK10.39631965
111BMPR1B0.39489936
112CSNK1D0.39107857
113MAP3K20.38200322
114FGFR20.37071280
115ARAF0.36939487
116SIK20.36873172
117GRK70.36201392
118WNK10.35951160
119PRKCA0.35282755
120PRKD10.34831667
121CAMK1D0.34445149
122STK110.34329088
123MAP3K60.33161713
124MAP2K10.32543355
125PDPK10.32435312
126PRKCB0.32317237
127RPS6KA30.31848230
128CDK150.31747021
129PDK10.31625104
130MKNK20.30941720
131CAMK40.30734744
132FGR0.30377556
133STK160.29714679
134RPS6KB10.28981418
135FES0.28504057
136CDK140.28348229
137PHKG20.27765813

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.41410632
2Nicotine addiction_Homo sapiens_hsa050333.08527137
3Synaptic vesicle cycle_Homo sapiens_hsa047213.08250150
4Collecting duct acid secretion_Homo sapiens_hsa049662.75245165
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.54880047
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.20325345
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.16766550
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.98463385
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.93023307
10Pyruvate metabolism_Homo sapiens_hsa006201.90424089
11GABAergic synapse_Homo sapiens_hsa047271.84749547
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81196436
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.80205319
14Phototransduction_Homo sapiens_hsa047441.77242575
15Butanoate metabolism_Homo sapiens_hsa006501.76319443
16Arginine biosynthesis_Homo sapiens_hsa002201.73893444
17Morphine addiction_Homo sapiens_hsa050321.71241114
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64534099
19Propanoate metabolism_Homo sapiens_hsa006401.59704232
20Olfactory transduction_Homo sapiens_hsa047401.57820597
21Circadian entrainment_Homo sapiens_hsa047131.55712557
22Amphetamine addiction_Homo sapiens_hsa050311.44980454
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.43946319
24Vibrio cholerae infection_Homo sapiens_hsa051101.43734273
25Glutamatergic synapse_Homo sapiens_hsa047241.42227157
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41941418
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29969085
28Fatty acid degradation_Homo sapiens_hsa000711.29714182
29Long-term potentiation_Homo sapiens_hsa047201.28688617
30Oxidative phosphorylation_Homo sapiens_hsa001901.27753321
31Fatty acid metabolism_Homo sapiens_hsa012121.25540917
32Linoleic acid metabolism_Homo sapiens_hsa005911.22757327
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21166595
34Vascular smooth muscle contraction_Homo sapiens_hsa042701.19708525
35Insulin secretion_Homo sapiens_hsa049111.19129503
36Taste transduction_Homo sapiens_hsa047421.17681837
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17557827
38Fatty acid elongation_Homo sapiens_hsa000621.17256000
39Pancreatic secretion_Homo sapiens_hsa049721.13953156
40Peroxisome_Homo sapiens_hsa041461.12525487
41Salivary secretion_Homo sapiens_hsa049701.11679653
42Nitrogen metabolism_Homo sapiens_hsa009101.09157727
43Tryptophan metabolism_Homo sapiens_hsa003801.07631806
44Phenylalanine metabolism_Homo sapiens_hsa003601.07060726
45Dopaminergic synapse_Homo sapiens_hsa047281.06928196
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03613485
47Arginine and proline metabolism_Homo sapiens_hsa003301.03555400
48Serotonergic synapse_Homo sapiens_hsa047261.01662715
49* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00996099
50Caffeine metabolism_Homo sapiens_hsa002321.00061445
51Carbon metabolism_Homo sapiens_hsa012000.99405789
52beta-Alanine metabolism_Homo sapiens_hsa004100.97128112
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.96202382
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.95585657
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95409544
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95265996
57Complement and coagulation cascades_Homo sapiens_hsa046100.95070716
58Renin secretion_Homo sapiens_hsa049240.93190160
59Calcium signaling pathway_Homo sapiens_hsa040200.92937468
60Bile secretion_Homo sapiens_hsa049760.90998778
61Sulfur metabolism_Homo sapiens_hsa009200.88321899
62Gap junction_Homo sapiens_hsa045400.87948708
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86173016
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85348658
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85049959
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84869401
67Long-term depression_Homo sapiens_hsa047300.84209916
68Retinol metabolism_Homo sapiens_hsa008300.84153601
69Dilated cardiomyopathy_Homo sapiens_hsa054140.83344540
70PPAR signaling pathway_Homo sapiens_hsa033200.83005640
71Tyrosine metabolism_Homo sapiens_hsa003500.79416716
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77668144
73Fat digestion and absorption_Homo sapiens_hsa049750.76379964
74Gastric acid secretion_Homo sapiens_hsa049710.75832098
75Histidine metabolism_Homo sapiens_hsa003400.74381082
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73315828
77Chemical carcinogenesis_Homo sapiens_hsa052040.72998658
78Biosynthesis of amino acids_Homo sapiens_hsa012300.71918670
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70840096
80Circadian rhythm_Homo sapiens_hsa047100.69640016
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69364039
82Mineral absorption_Homo sapiens_hsa049780.69176466
83Cholinergic synapse_Homo sapiens_hsa047250.68911347
84Arachidonic acid metabolism_Homo sapiens_hsa005900.68688287
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68446291
86Rheumatoid arthritis_Homo sapiens_hsa053230.68071724
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67871651
88Cocaine addiction_Homo sapiens_hsa050300.66872838
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64740769
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63908893
91Alzheimers disease_Homo sapiens_hsa050100.63752613
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.63620893
93Oxytocin signaling pathway_Homo sapiens_hsa049210.62684846
94Fatty acid biosynthesis_Homo sapiens_hsa000610.62483211
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60630338
96Vitamin B6 metabolism_Homo sapiens_hsa007500.60036001
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57508612
98Platelet activation_Homo sapiens_hsa046110.54497979
99Glucagon signaling pathway_Homo sapiens_hsa049220.54293315
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52187738
101Vitamin digestion and absorption_Homo sapiens_hsa049770.51963052
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50902155
103Parkinsons disease_Homo sapiens_hsa050120.49467952
104cAMP signaling pathway_Homo sapiens_hsa040240.49087317
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48286583
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.47593198
107Dorso-ventral axis formation_Homo sapiens_hsa043200.47323838
108Glycerolipid metabolism_Homo sapiens_hsa005610.47316048
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47094900
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46883342
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44959080
112Starch and sucrose metabolism_Homo sapiens_hsa005000.44421520
113Ovarian steroidogenesis_Homo sapiens_hsa049130.44289679
114Thyroid hormone synthesis_Homo sapiens_hsa049180.43115893
115ABC transporters_Homo sapiens_hsa020100.42573370
116Type II diabetes mellitus_Homo sapiens_hsa049300.42518996
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.42510931
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42385494
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42206969
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40080435
121Phagosome_Homo sapiens_hsa041450.38212367
122Cardiac muscle contraction_Homo sapiens_hsa042600.38155247
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37755625
124GnRH signaling pathway_Homo sapiens_hsa049120.37628559

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