THSD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a type 1 thrombospondin domain, which is found in a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelium development (GO:0003158)9.83665508
2lymph vessel development (GO:0001945)9.48133005
3hemidesmosome assembly (GO:0031581)7.95353826
4positive regulation of vasculogenesis (GO:2001214)7.48981588
5vascular endothelial growth factor signaling pathway (GO:0038084)6.47988288
6regulation of vasculogenesis (GO:2001212)6.17697856
7blood vessel maturation (GO:0001955)6.16204656
8viral transcription (GO:0019083)5.79930797
9negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)5.65759540
10cellular response to vascular endothelial growth factor stimulus (GO:0035924)5.58899308
11morphogenesis of an endothelium (GO:0003159)5.47500954
12endothelial tube morphogenesis (GO:0061154)5.47500954
13translational termination (GO:0006415)5.47414740
14ribosomal small subunit assembly (GO:0000028)5.42372437
15definitive hemopoiesis (GO:0060216)5.21193197
16lymphangiogenesis (GO:0001946)5.14284657
17angiogenesis involved in wound healing (GO:0060055)4.99644792
18retina vasculature morphogenesis in camera-type eye (GO:0061299)4.83025033
19bundle of His cell to Purkinje myocyte communication (GO:0086069)4.75906966
20wound healing, spreading of epidermal cells (GO:0035313)4.58701333
21translational elongation (GO:0006414)4.52304801
22ribosomal small subunit biogenesis (GO:0042274)4.50367557
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.47147179
24vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.44138112
25sprouting angiogenesis (GO:0002040)4.38329091
26cotranslational protein targeting to membrane (GO:0006613)4.37994453
27protein targeting to ER (GO:0045047)4.34838880
28cell-substrate junction assembly (GO:0007044)4.32264163
29viral life cycle (GO:0019058)4.31739526
30positive regulation of odontogenesis (GO:0042482)4.29270561
31endothelial cell differentiation (GO:0045446)4.26662880
32ventricular trabecula myocardium morphogenesis (GO:0003222)4.22203446
33establishment of protein localization to endoplasmic reticulum (GO:0072599)4.15716405
34glomerular filtration (GO:0003094)4.14781906
35surfactant homeostasis (GO:0043129)4.06056119
36protein localization to endoplasmic reticulum (GO:0070972)4.05648171
37basement membrane organization (GO:0071711)4.05237079
38regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)4.04786899
39artery development (GO:0060840)3.99897817
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.94346727
41platelet dense granule organization (GO:0060155)3.92222432
42regulation of endothelial cell differentiation (GO:0045601)3.92153201
43cellular protein complex disassembly (GO:0043624)3.84290822
44negative regulation of endothelial cell apoptotic process (GO:2000352)3.77080659
45cell adhesion mediated by integrin (GO:0033627)3.76555208
46embryonic heart tube development (GO:0035050)3.73328006
47vasculogenesis (GO:0001570)3.71202631
48renal filtration (GO:0097205)3.69206077
49endodermal cell differentiation (GO:0035987)3.65881659
50maturation of SSU-rRNA (GO:0030490)3.63047072
51patterning of blood vessels (GO:0001569)3.61193689
52ovulation from ovarian follicle (GO:0001542)3.58438208
53negative regulation of keratinocyte proliferation (GO:0010839)3.48422580
54regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.47902272
55dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.44676780
56regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.43305036
57translational initiation (GO:0006413)3.41634497
58negative regulation of nitric oxide biosynthetic process (GO:0045019)3.41546264
59substrate-dependent cell migration (GO:0006929)3.39533370
60megakaryocyte development (GO:0035855)3.39105223
61peptidyl-tyrosine autophosphorylation (GO:0038083)3.37084107
62venous blood vessel morphogenesis (GO:0048845)3.35256358
63negative regulation of blood vessel endothelial cell migration (GO:0043537)3.35247052
64regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.35170395
65plasma membrane repair (GO:0001778)3.33528464
66negative regulation of nitric-oxide synthase activity (GO:0051001)3.29213143
67endothelial cell morphogenesis (GO:0001886)3.27659867
68protein complex disassembly (GO:0043241)3.26104578
69regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.24358709
70wound healing, spreading of cells (GO:0044319)3.22209927
71negative regulation of chondrocyte differentiation (GO:0032331)3.21790704
72regulation of blood vessel endothelial cell migration (GO:0043535)3.15485872
73endothelial cell proliferation (GO:0001935)3.12115278
74hyaluronan catabolic process (GO:0030214)3.12093424
75blood vessel endothelial cell migration (GO:0043534)3.09534375
76regulation of transforming growth factor beta2 production (GO:0032909)3.05858753
77regulation of endothelial cell apoptotic process (GO:2000351)3.05724589
78lymphoid progenitor cell differentiation (GO:0002320)3.02103778
79protein targeting to membrane (GO:0006612)3.02015649
80gap junction assembly (GO:0016264)3.01463062
81cAMP biosynthetic process (GO:0006171)3.00187697
82negative regulation of stress fiber assembly (GO:0051497)2.97917088
83mRNA transcription from RNA polymerase II promoter (GO:0042789)2.96715981
84negative regulation of protein localization to cell surface (GO:2000009)2.96226524
85macromolecular complex disassembly (GO:0032984)2.95774459
86sphingosine metabolic process (GO:0006670)2.94623432
87antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.94326199
88antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.94326199
89positive regulation of blood vessel endothelial cell migration (GO:0043536)2.91145604
90germ cell migration (GO:0008354)2.90531479
91axon extension involved in axon guidance (GO:0048846)2.90306944
92neuron projection extension involved in neuron projection guidance (GO:1902284)2.90306944
93negative regulation of epithelial cell migration (GO:0010633)2.89257962
94transcytosis (GO:0045056)2.89089793
95heart trabecula formation (GO:0060347)2.87565655
96chemical homeostasis within a tissue (GO:0048875)2.86123874
97heart valve formation (GO:0003188)2.84654275
98embryonic hemopoiesis (GO:0035162)2.84231760
99negative regulation of endothelial cell migration (GO:0010596)2.82837305
100positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.82563786
101regulation of sarcomere organization (GO:0060297)2.81582641
102cell migration involved in sprouting angiogenesis (GO:0002042)2.81433605
103response to interferon-beta (GO:0035456)2.81399569
104regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.80612137
105heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.79970407
106sodium-independent organic anion transport (GO:0043252)2.79085102
107epithelial cell differentiation involved in kidney development (GO:0035850)2.78692600
108arginine catabolic process (GO:0006527)2.77634923
109negative regulation of vascular permeability (GO:0043116)2.75670198
110positive regulation of endothelial cell differentiation (GO:0045603)2.75225714
111positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.75170359
112regulation of endothelial cell migration (GO:0010594)2.74967908
113negative regulation of focal adhesion assembly (GO:0051895)2.74811862
114negative regulation of cell junction assembly (GO:1901889)2.74811862
115negative regulation of adherens junction organization (GO:1903392)2.74811862
116regulation of positive chemotaxis (GO:0050926)2.74810613
117cell migration involved in heart development (GO:0060973)2.74729095
118keratinocyte proliferation (GO:0043616)2.74122483
119regulation of glomerular filtration (GO:0003093)2.73425772
120positive regulation of focal adhesion assembly (GO:0051894)2.73395828
121positive regulation of cell junction assembly (GO:1901890)2.73395828
122positive regulation of endothelial cell migration (GO:0010595)2.72984372
123adherens junction assembly (GO:0034333)2.72089855
124positive regulation of lipid kinase activity (GO:0090218)2.70928613
125blood vessel remodeling (GO:0001974)2.70497097
126negative regulation of glycoprotein biosynthetic process (GO:0010561)2.68874895
127Notch signaling involved in heart development (GO:0061314)2.68442390
128negative regulation of cell fate specification (GO:0009996)2.67152955
129response to interferon-alpha (GO:0035455)2.67151175
130Notch receptor processing (GO:0007220)2.66761338
131heart trabecula morphogenesis (GO:0061384)2.65612898
132regulation of epithelial cell migration (GO:0010632)2.65333877
133response to muscle activity (GO:0014850)2.65295288
134angiogenesis (GO:0001525)2.64649323
135heparin metabolic process (GO:0030202)2.64011989
136heparin biosynthetic process (GO:0030210)2.64011989
137cardiac epithelial to mesenchymal transition (GO:0060317)2.62919039
138SMAD protein complex assembly (GO:0007183)2.61947885
139nuclear-transcribed mRNA catabolic process (GO:0000956)2.61833028
140endothelial cell migration (GO:0043542)2.61791908
141semaphorin-plexin signaling pathway (GO:0071526)2.61000685
142trabecula morphogenesis (GO:0061383)2.60687405
143positive regulation of epithelial cell migration (GO:0010634)2.59727328
144establishment of endothelial barrier (GO:0061028)2.59626470
145cell junction assembly (GO:0034329)2.59206050
146mesodermal cell differentiation (GO:0048333)2.58394263
147neuron remodeling (GO:0016322)2.57062680
148diol metabolic process (GO:0034311)2.56424751
149ganglion development (GO:0061548)2.52998881
150epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.52310577
151glomerular basement membrane development (GO:0032836)2.52071548
152regulation of keratinocyte proliferation (GO:0010837)2.50539351

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.59825498
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.24130232
3SCL_19346495_ChIP-Seq_HPC-7_Human4.81266929
4GATA2_21666600_ChIP-Seq_HMVEC_Human4.40543566
5GATA1_22025678_ChIP-Seq_K562_Human3.88531454
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.33605314
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.31591951
8STAT6_21828071_ChIP-Seq_BEAS2B_Human3.18087869
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.88205356
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.74526211
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.72077981
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.68918477
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.66173337
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.48530069
15* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.41828038
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.36790272
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.29923378
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.25452672
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.22160972
20CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.17312096
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.16375189
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14858075
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.13929629
24RNF2_18974828_ChIP-Seq_MESCs_Mouse2.07375930
25EZH2_18974828_ChIP-Seq_MESCs_Mouse2.07375930
26WT1_19549856_ChIP-ChIP_CCG9911_Human2.05176585
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.01568719
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.95218816
29RUNX_20019798_ChIP-Seq_JUKART_Human1.90899963
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.86323401
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.83844961
32ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.83472076
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81681797
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.81170630
35* BRD4_25478319_ChIP-Seq_HGPS_Human1.78169022
36TCF7_22412390_ChIP-Seq_EML_Mouse1.71611906
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69217988
38GATA1_19941826_ChIP-Seq_K562_Human1.69154727
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.68200699
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66236549
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65786919
42* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.62475052
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59774556
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59603749
45RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.57529672
46SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.56398737
47SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.56398737
48CLOCK_20551151_ChIP-Seq_293T_Human1.54391493
49MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54158860
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52433055
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50743505
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48578198
53* SOX2_20726797_ChIP-Seq_SW620_Human1.46680589
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.46631665
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.46456381
56TP53_18474530_ChIP-ChIP_U2OS_Human1.46259142
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45655716
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45217443
59SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44708927
60MAF_26560356_Chip-Seq_TH1_Human1.43284273
61* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43127339
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.43094258
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42710573
64JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42110687
65KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.41734084
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.41734084
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.41734084
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40881238
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40413487
70SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39838096
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39669870
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.38630654
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38456946
74EGR1_19374776_ChIP-ChIP_THP-1_Human1.37292286
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37207263
76SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37088307
77CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.35526390
78TP53_22127205_ChIP-Seq_IMR90_Human1.33068431
79RNF2_27304074_Chip-Seq_ESCs_Mouse1.32590290
80EP300_21415370_ChIP-Seq_HL-1_Mouse1.31968372
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31757990
82* TP63_23658742_ChIP-Seq_EP156T_Human1.31298606
83VDR_21846776_ChIP-Seq_THP-1_Human1.30114058
84TP53_23651856_ChIP-Seq_MEFs_Mouse1.29725538
85AR_21572438_ChIP-Seq_LNCaP_Human1.29440986
86UBF1/2_26484160_Chip-Seq_HMECs_Human1.29147668
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28242277
88JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27775030
89* EZH2_27294783_Chip-Seq_ESCs_Mouse1.26376848
90* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26261816
91TP53_20018659_ChIP-ChIP_R1E_Mouse1.25861298
92SPI1_23547873_ChIP-Seq_NB4_Human1.25554397
93BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25101601
94ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.24114266
95VDR_24763502_ChIP-Seq_THP-1_Human1.23148419
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23063945
97TBX20_22080862_ChIP-Seq_HEART_Mouse1.20491413
98TBX20_22328084_ChIP-Seq_HEART_Mouse1.20491413
99JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19690824
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18832745
101P63_26484246_Chip-Seq_KERATINOCYTES_Human1.18389361
102PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17218822
103RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16990045
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15498857
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14224476
106MYC_22102868_ChIP-Seq_BL_Human1.13669010
107CJUN_26792858_Chip-Seq_BT549_Human1.13103808
108CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12840356
109TCF4_18268006_ChIP-ChIP_LS174T_Human1.12450050
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12422155
111SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12111970
112SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11244753
113SPI1_23127762_ChIP-Seq_K562_Human1.11131702
114NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10657413
115GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10506688
116UTX_26944678_Chip-Seq_JUKART_Human1.09719633
117RING1B_27294783_Chip-Seq_ESCs_Mouse1.09567233
118STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.08068688
119GATA2_19941826_ChIP-Seq_K562_Human1.07940400
120P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07722333
121CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07380133
122WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07325266
123PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06852373
124ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.06635707
125PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05519287
126HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05359197
127SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05057847
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04706195
129TET1_21490601_ChIP-Seq_MESCs_Mouse1.04571084
130GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03753106
131* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03040458
132CDX2_20551321_ChIP-Seq_CACO-2_Human1.01885412
133NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00595559
134SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00180651
135RUNX1_22412390_ChIP-Seq_EML_Mouse0.99772413
136MYB_26560356_Chip-Seq_TH1_Human0.99637941
137RXR_22108803_ChIP-Seq_LS180_Human0.99019902
138AHR_22903824_ChIP-Seq_MCF-7_Human0.97351431
139TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96986136
140NCOR1_26117541_ChIP-Seq_K562_Human0.96085245
141MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95551551
142TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94488936
143FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94468770
144KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93623195
145NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93287316
146NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93287316
147KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92534757
148WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91424433
149TP63_22573176_ChIP-Seq_HFKS_Human0.90779553
150EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90763345
151PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90282161
152PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89831187
153DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89490853
154TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89407293
155TP53_16413492_ChIP-PET_HCT116_Human0.89251497
156MYC_18555785_ChIP-Seq_MESCs_Mouse0.88328023
157PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87124442
158SMC1_22415368_ChIP-Seq_MEFs_Mouse0.86715504
159MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.86642612
160KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86468345
161MYB_26560356_Chip-Seq_TH2_Human0.84729143
162GBX2_23144817_ChIP-Seq_PC3_Human0.84672118
163SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84014366
164PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83701266
165RING1B_27294783_Chip-Seq_NPCs_Mouse0.83675113
166IGF1R_20145208_ChIP-Seq_DFB_Human0.82980850
167ERG_21242973_ChIP-ChIP_JURKAT_Human0.82325218
168ISL1_27105846_Chip-Seq_CPCs_Mouse0.81916727

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system6.83383952
2MP0001879_abnormal_lymphatic_vessel5.92897234
3MP0005167_abnormal_blood-brain_barrier5.57096066
4MP0009379_abnormal_foot_pigmentation4.42768858
5MP0004272_abnormal_basement_membrane3.50528751
6MP0008438_abnormal_cutaneous_collagen3.11099926
7MP0003828_pulmonary_edema2.88143704
8MP0006054_spinal_hemorrhage2.67814767
9MP0004147_increased_porphyrin_level2.53493165
10MP0009697_abnormal_copulation2.43835610
11MP0010234_abnormal_vibrissa_follicle2.41878904
12MP0000749_muscle_degeneration2.34910586
13MP0003724_increased_susceptibility_to2.33383843
14MP0000579_abnormal_nail_morphology2.33340758
15MP0005409_darkened_coat_color2.15547657
16MP0000465_gastrointestinal_hemorrhage2.14902057
17MP0000013_abnormal_adipose_tissue2.10131309
18MP0009278_abnormal_bone_marrow2.09361586
19MP0004808_abnormal_hematopoietic_stem1.90061490
20MP0000751_myopathy1.89457956
21MP0009053_abnormal_anal_canal1.87623123
22MP0003279_aneurysm1.82315581
23MP0006138_congestive_heart_failure1.73323350
24MP0004084_abnormal_cardiac_muscle1.70478000
25MP0000767_abnormal_smooth_muscle1.69453110
26MP0001545_abnormal_hematopoietic_system1.68319704
27MP0005397_hematopoietic_system_phenotyp1.68319704
28MP0000762_abnormal_tongue_morphology1.66818260
29MP0002396_abnormal_hematopoietic_system1.66174889
30MP0005084_abnormal_gallbladder_morpholo1.63194009
31MP0000467_abnormal_esophagus_morphology1.58755442
32MP0001849_ear_inflammation1.56781426
33MP0010030_abnormal_orbit_morphology1.54933647
34MP0003045_fibrosis1.46750056
35MP0000249_abnormal_blood_vessel1.41582981
36MP0002098_abnormal_vibrissa_morphology1.38579960
37MP0000537_abnormal_urethra_morphology1.38127111
38MP0003705_abnormal_hypodermis_morpholog1.37368684
39MP0001188_hyperpigmentation1.35836478
40MP0003191_abnormal_cellular_cholesterol1.35676014
41MP0003943_abnormal_hepatobiliary_system1.35022035
42MP0002127_abnormal_cardiovascular_syste1.34898187
43MP0005257_abnormal_intraocular_pressure1.33277294
44MP0002332_abnormal_exercise_endurance1.32153731
45MP0003567_abnormal_fetal_cardiomyocyte1.31445513
46MP0003300_gastrointestinal_ulcer1.30948386
47MP0005165_increased_susceptibility_to1.29775705
48MP0005623_abnormal_meninges_morphology1.26900800
49MP0002128_abnormal_blood_circulation1.24872311
50MP0002837_dystrophic_cardiac_calcinosis1.23899704
51MP0005503_abnormal_tendon_morphology1.23782449
52MP0000733_abnormal_muscle_development1.21951764
53MP0005595_abnormal_vascular_smooth1.18662927
54MP0002108_abnormal_muscle_morphology1.16119162
55MP0000750_abnormal_muscle_regeneration1.15544907
56MP0009785_altered_susceptibility_to1.15006000
57MP0004233_abnormal_muscle_weight1.14585018
58MP0002925_abnormal_cardiovascular_devel1.12789845
59MP0004215_abnormal_myocardial_fiber1.12531640
60MP0005385_cardiovascular_system_phenoty1.11361685
61MP0001544_abnormal_cardiovascular_syste1.11361685
62MP0000343_altered_response_to1.09280385
63MP0005275_abnormal_skin_tensile1.08898037
64MP0002796_impaired_skin_barrier1.07745834
65MP0001614_abnormal_blood_vessel1.06967805
66MP0010630_abnormal_cardiac_muscle1.06874085
67MP0001873_stomach_inflammation1.04800913
68MP0003385_abnormal_body_wall1.03765303
69MP0000759_abnormal_skeletal_muscle1.03322320
70MP0003638_abnormal_response/metabolism_1.02710435
71MP0000003_abnormal_adipose_tissue1.01847768
72MP0002138_abnormal_hepatobiliary_system1.01642430
73MP0010678_abnormal_skin_adnexa1.01202311
74MP0001661_extended_life_span0.98795939
75MP0002166_altered_tumor_susceptibility0.98551068
76MP0005171_absent_coat_pigmentation0.98141326
77MP0003566_abnormal_cell_adhesion0.96625615
78MP0004484_altered_response_of0.96078045
79MP0002249_abnormal_larynx_morphology0.95413345
80MP0004883_abnormal_blood_vessel0.95392201
81MP0002234_abnormal_pharynx_morphology0.94578044
82MP0004087_abnormal_muscle_fiber0.92602246
83MP0000534_abnormal_ureter_morphology0.91787787
84MP0005330_cardiomyopathy0.90851791
85MP0009333_abnormal_splenocyte_physiolog0.89473241
86MP0002295_abnormal_pulmonary_circulatio0.89471096
87MP0005620_abnormal_muscle_contractility0.87933097
88MP0010155_abnormal_intestine_physiology0.87296456
89MP0001915_intracranial_hemorrhage0.87199608
90MP0003315_abnormal_perineum_morphology0.84614135
91MP0005671_abnormal_response_to0.84511718
92MP0009764_decreased_sensitivity_to0.83528505
93MP0005501_abnormal_skin_physiology0.82236788
94MP0001853_heart_inflammation0.81556667
95MP0001784_abnormal_fluid_regulation0.81378106
96MP0010771_integument_phenotype0.80298632
97MP0004036_abnormal_muscle_relaxation0.79970754
98MP0009384_cardiac_valve_regurgitation0.79774746
99MP0000383_abnormal_hair_follicle0.79146636
100MP0005164_abnormal_response_to0.78553886
101MP0003091_abnormal_cell_migration0.77605919
102MP0000372_irregular_coat_pigmentation0.77581143
103MP0002972_abnormal_cardiac_muscle0.76439317
104MP0001191_abnormal_skin_condition0.76344820
105MP0004782_abnormal_surfactant_physiolog0.75802009
106MP0005360_urolithiasis0.75668961
107MP0003935_abnormal_craniofacial_develop0.75598075
108MP0002060_abnormal_skin_morphology0.74655767
109MP0008995_early_reproductive_senescence0.74642740
110MP0005464_abnormal_platelet_physiology0.73940828
111MP0003122_maternal_imprinting0.73846054
112MP0001542_abnormal_bone_strength0.73728426
113MP0005023_abnormal_wound_healing0.73550870
114MP0009780_abnormal_chondrocyte_physiolo0.73429655
115MP0003941_abnormal_skin_development0.73234922
116MP0008775_abnormal_heart_ventricle0.73211998
117MP0002896_abnormal_bone_mineralization0.71662046
118MP0000377_abnormal_hair_follicle0.70396920
119MP0009250_abnormal_appendicular_skeleto0.69666315
120MP0000266_abnormal_heart_morphology0.68819926
121MP0005369_muscle_phenotype0.67825969
122MP0001958_emphysema0.66897912
123MP0005197_abnormal_uvea_morphology0.66745603
124MP0002106_abnormal_muscle_physiology0.66675482
125MP0001851_eye_inflammation0.65767364
126MP0002168_other_aberrant_phenotype0.65671146
127MP0005025_abnormal_response_to0.64121808
128MP0003453_abnormal_keratinocyte_physiol0.63905596
129MP0004381_abnormal_hair_follicle0.62905166
130MP0004145_abnormal_muscle_electrophysio0.62543209
131MP0001835_abnormal_antigen_presentation0.62540491
132MP0004885_abnormal_endolymph0.62081426
133MP0010352_gastrointestinal_tract_polyps0.61826408
134MP0005508_abnormal_skeleton_morphology0.61774111
135MP0003950_abnormal_plasma_membrane0.61164816
136MP0002269_muscular_atrophy0.61078073
137MP0002638_abnormal_pupillary_reflex0.60668731
138MP0002282_abnormal_trachea_morphology0.60206044
139MP0004085_abnormal_heartbeat0.60151880
140MP0005174_abnormal_tail_pigmentation0.59926749
141MP0001216_abnormal_epidermal_layer0.59610943
142MP0001299_abnormal_eye_distance/0.59060587
143MP0002095_abnormal_skin_pigmentation0.58521996
144MP0000230_abnormal_systemic_arterial0.55942852
145MP0005187_abnormal_penis_morphology0.55599476
146MP0002086_abnormal_extraembryonic_tissu0.52494244
147MP0002420_abnormal_adaptive_immunity0.52304737

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous hematomas (HP:0007420)6.22381890
2Hematochezia (HP:0002573)5.15163027
3Abnormality of cells of the erythroid lineage (HP:0012130)5.07042499
4Atrophic scars (HP:0001075)5.04088567
5Polycythemia (HP:0001901)4.86622195
6Reticulocytopenia (HP:0001896)4.81157256
7Abnormal number of erythroid precursors (HP:0012131)4.58966075
8Asymmetry of the thorax (HP:0001555)4.09833830
9Fragile nails (HP:0001808)4.04121824
10Premature rupture of membranes (HP:0001788)4.02182573
11Popliteal pterygium (HP:0009756)4.01596707
12Nonimmune hydrops fetalis (HP:0001790)3.80377399
13Abnormality of placental membranes (HP:0011409)3.68602398
14Amniotic constriction ring (HP:0009775)3.68602398
15Esophageal varix (HP:0002040)3.64878764
16Congenital, generalized hypertrichosis (HP:0004540)3.59584410
17Abnormality of the nasal mucosa (HP:0000433)3.57515592
18Thrombocytosis (HP:0001894)3.49923563
19Aortic aneurysm (HP:0004942)3.45812980
20Lymphangioma (HP:0100764)3.42171894
21Portal hypertension (HP:0001409)3.37632930
22Stenosis of the external auditory canal (HP:0000402)3.33521420
23Hypotrichosis (HP:0001006)3.28168560
24Increased IgE level (HP:0003212)3.26876647
25Broad metatarsal (HP:0001783)3.26227530
26Pterygium (HP:0001059)3.25098783
27Plantar hyperkeratosis (HP:0007556)3.16280045
28Round ear (HP:0100830)3.11747995
29Elevated erythrocyte sedimentation rate (HP:0003565)3.10674253
30Onycholysis (HP:0001806)3.05232327
31Abnormality of the hepatic vasculature (HP:0006707)3.03598999
32Microcytic anemia (HP:0001935)3.02180029
33Follicular hyperkeratosis (HP:0007502)3.01249092
34Fragile skin (HP:0001030)2.97203871
35Visceral angiomatosis (HP:0100761)2.89902598
36Thick nail (HP:0001805)2.89628436
37Abnormality of nail color (HP:0100643)2.88996209
38Distal arthrogryposis (HP:0005684)2.85095835
39Abnormality of secondary sexual hair (HP:0009888)2.83479001
40Abnormality of the axillary hair (HP:0100134)2.83479001
41Hemangiomatosis (HP:0007461)2.83104124
42Type 1 muscle fiber predominance (HP:0003803)2.80505346
43Hyporeflexia of lower limbs (HP:0002600)2.79821171
44Difficulty climbing stairs (HP:0003551)2.79515265
45Protrusio acetabuli (HP:0003179)2.78647574
46Pallor (HP:0000980)2.77334435
47Increased variability in muscle fiber diameter (HP:0003557)2.74554922
48Prolonged bleeding time (HP:0003010)2.70106957
49Chronic otitis media (HP:0000389)2.69555376
50Abnormality of the neuromuscular junction (HP:0003398)2.69237403
51Fatigable weakness (HP:0003473)2.69237403
52Cerebral hemorrhage (HP:0001342)2.65512561
53Macrocytic anemia (HP:0001972)2.62859647
54Myotonia (HP:0002486)2.61683956
55Conjunctival telangiectasia (HP:0000524)2.59154381
56Nemaline bodies (HP:0003798)2.58921450
57Absent hand (HP:0004050)2.56749024
58Malignant hyperthermia (HP:0002047)2.56079186
59Woolly hair (HP:0002224)2.55644371
60Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.53697705
61Shallow orbits (HP:0000586)2.53537638
62Difficulty running (HP:0009046)2.45169048
63Wrist flexion contracture (HP:0001239)2.44535471
64Reduced subcutaneous adipose tissue (HP:0003758)2.41968732
65Ulnar deviation of the wrist (HP:0003049)2.41564487
66Epistaxis (HP:0000421)2.41354479
67Muscle fiber inclusion bodies (HP:0100299)2.38142183
68Acute myeloid leukemia (HP:0004808)2.38007058
69Weak cry (HP:0001612)2.37725421
70Myositis (HP:0100614)2.37201325
71Erythema (HP:0010783)2.36116938
72Scapular winging (HP:0003691)2.35933527
73Pulmonary embolism (HP:0002204)2.34117891
74Ventricular tachycardia (HP:0004756)2.33735697
75Right ventricular cardiomyopathy (HP:0011663)2.29399287
76Nail dystrophy (HP:0008404)2.29311001
77Abnormality of the vasculature of the conjunctiva (HP:0008054)2.27695348
78Porencephaly (HP:0002132)2.26810842
79Capillary hemangiomas (HP:0005306)2.26300801
80Hypoplasia of the iris (HP:0007676)2.25544272
81Migraine (HP:0002076)2.24054574
82Asplenia (HP:0001746)2.23598693
83Vertebral arch anomaly (HP:0008438)2.22946475
84Adactyly (HP:0009776)2.22668062
85Limited hip movement (HP:0008800)2.22356614
86Increased connective tissue (HP:0009025)2.20009087
87Bladder diverticulum (HP:0000015)2.19947934
88Coronal craniosynostosis (HP:0004440)2.18922095
89Overgrowth (HP:0001548)2.17583253
90IgM deficiency (HP:0002850)2.16289615
91Abnormality of the phalanges of the 2nd finger (HP:0009541)2.16225774
92Abnormality of the anterior chamber (HP:0000593)2.16178913
93Alopecia of scalp (HP:0002293)2.15422863
94Hip contracture (HP:0003273)2.13986353
95Spinal rigidity (HP:0003306)2.11245841
96Petechiae (HP:0000967)2.09667308
97Wormian bones (HP:0002645)2.09597975
98Thin ribs (HP:0000883)2.07276312
99Short 4th metacarpal (HP:0010044)2.06678060
100Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.06678060
101Mesangial abnormality (HP:0001966)2.06545233
102Aplasia cutis congenita (HP:0001057)2.06239517
103Cervical subluxation (HP:0003308)2.05424186
104Generalized amyotrophy (HP:0003700)2.04535348
105Vascular tortuosity (HP:0004948)2.04121113
106Aplasia of the musculature (HP:0100854)2.03694336
107Abnormal hemoglobin (HP:0011902)2.03434192
108Absent phalangeal crease (HP:0006109)2.01372113
109Cardiovascular calcification (HP:0011915)1.99582903
110Acanthosis nigricans (HP:0000956)1.98029495
111Arterial tortuosity (HP:0005116)1.97602974
112Asymmetric septal hypertrophy (HP:0001670)1.96840484
113Cavernous hemangioma (HP:0001048)1.96516716
114Aplasia/Hypoplasia of the spleen (HP:0010451)1.93171969
115Abnormality of the peritoneum (HP:0002585)1.92988653
116Abnormal platelet function (HP:0011869)1.92915155
117Impaired platelet aggregation (HP:0003540)1.92915155
118Trismus (HP:0000211)1.92779427
119Joint hemorrhage (HP:0005261)1.91794637
120Tetraparesis (HP:0002273)1.91213423
121Anterior segment dysgenesis (HP:0007700)1.91211578
122Thrombophlebitis (HP:0004418)1.91060900
123Amyloidosis (HP:0011034)1.90236886
124Ridged nail (HP:0001807)1.89880956
125Deep venous thrombosis (HP:0002625)1.89492339
126Atrioventricular block (HP:0001678)1.89417946
127Palmoplantar hyperkeratosis (HP:0000972)1.89309905
128Knee flexion contracture (HP:0006380)1.89263809
129Aortic valve stenosis (HP:0001650)1.88648355
130Skull defect (HP:0001362)1.88446347
131Abnormality of skeletal muscle fiber size (HP:0012084)1.88358805
132Exercise-induced myalgia (HP:0003738)1.88237442
133Mucosal telangiectasiae (HP:0100579)1.86922291
134Pulmonary hypertension (HP:0002092)1.86690017
135Venous insufficiency (HP:0005293)1.86390595
136Cerebral aneurysm (HP:0004944)1.86275529
137Broad ribs (HP:0000885)1.85512711
138Down-sloping shoulders (HP:0200021)1.85089931
139Natal tooth (HP:0000695)1.84714614
140Hypoproteinemia (HP:0003075)1.84651540
141Abnormality of the calf musculature (HP:0001430)1.83282313
142Gowers sign (HP:0003391)1.82950805
143Ulnar bowing (HP:0003031)1.82490623
144Ankle contracture (HP:0006466)1.81771109
145Joint stiffness (HP:0001387)1.81325495
14611 pairs of ribs (HP:0000878)1.81172629
147Aplastic anemia (HP:0001915)1.80623893
148Bicuspid aortic valve (HP:0001647)1.80289729
149Cellulitis (HP:0100658)1.80141567
150Reduced antithrombin III activity (HP:0001976)1.78841856
151Delayed CNS myelination (HP:0002188)1.78585678
152Fetal akinesia sequence (HP:0001989)1.77545191
153Milia (HP:0001056)1.76354382
154Distal lower limb muscle weakness (HP:0009053)1.75047636
155Cutis marmorata (HP:0000965)1.74161786
156Neonatal death (HP:0003811)1.72225405
157Thin bony cortex (HP:0002753)1.72196067
158Mitral regurgitation (HP:0001653)1.71523263
159Hemorrhage of the eye (HP:0011885)1.71367421
160Abnormality of the 2nd finger (HP:0004100)1.70733363
161Muscle fiber splitting (HP:0003555)1.70631464
162Aortic dissection (HP:0002647)1.69926786
163Short hallux (HP:0010109)1.68239901
164Chest pain (HP:0100749)1.67257322
165Pulmonary artery stenosis (HP:0004415)1.66609372
166Thyroid-stimulating hormone excess (HP:0002925)1.65622537
167Absent eyelashes (HP:0000561)1.63293913
168Sparse scalp hair (HP:0002209)1.62951017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE19.04156687
2KDR6.23507437
3TGFBR13.74424829
4TGFBR23.37044910
5GRK12.92879655
6LATS22.92054422
7MET2.60325729
8ACVR1B2.42644148
9NTRK12.33060299
10PNCK2.28312329
11MAP2K32.20268016
12PTK22.10649837
13STK38L2.02218119
14FLT31.98505080
15KIT1.92694362
16TNIK1.87695236
17MOS1.79693904
18PDGFRA1.73614491
19TEC1.69649957
20PRKD31.68334114
21PKN21.67115958
22MAP4K11.59756957
23PTK2B1.55345390
24ARAF1.55127250
25FGFR21.47234032
26ERN11.44805461
27MAP3K31.39997483
28EPHB21.39980833
29PIK3CG1.37095851
30PRKG21.29653802
31LRRK21.26595768
32MAP3K111.26503097
33MAPKAPK31.24393038
34BTK1.24258237
35PTK61.23059757
36MAPK121.15224190
37FES1.14797882
38NLK1.14033150
39MYLK1.12144986
40STK381.10597572
41OBSCN1.03175415
42RPS6KB21.02966112
43EEF2K1.02660054
44MATK1.00431771
45LIMK10.96622930
46NUAK10.96104181
47NME20.95511969
48MST1R0.95350715
49RIPK10.91513186
50CLK10.88624729
51PDGFRB0.87151352
52BMPR1B0.86623081
53ROCK10.86353379
54MKNK10.86279705
55CDK80.86190935
56PIM20.85184737
57ROCK20.83570174
58CSF1R0.82958451
59EPHA20.82338118
60KSR20.79377088
61SIK10.78780511
62TBK10.77678213
63PAK40.76155940
64FER0.75748330
65ITK0.72451081
66FGFR40.70807533
67EPHB10.70374430
68PINK10.68425040
69MUSK0.68368277
70RPS6KA20.66370774
71MAPKAPK50.64694881
72MKNK20.64544217
73BMX0.64478550
74STK160.64028745
75MAP3K60.61874761
76JAK30.60108237
77VRK10.60001796
78MARK10.59436623
79PRKD20.59177649
80TAOK20.55891614
81MAPK70.55432836
82FGFR30.54939598
83IRAK30.54865025
84STK100.52858484
85MARK20.52742623
86ADRBK20.52383414
87LCK0.51955569
88MAP3K90.50051548
89YES10.49599915
90MAP2K20.49463620
91MAPK40.48756245
92ZAP700.48607297
93PRKAA20.47054518
94GSK3A0.46113845
95CAMKK20.46001286
96PRKD10.45750833
97PAK20.45476391
98WEE10.44883740
99LMTK20.44349611
100TESK10.43997184
101DAPK30.43930787
102IGF1R0.43113406
103ERBB40.42926699
104ILK0.42713154
105MAP2K60.42447465
106ADRBK10.42288356
107LATS10.37713929
108MAP2K10.37036867
109STK30.36802756
110PHKG20.36259946
111PHKG10.36259946
112LYN0.36134942
113PLK20.35358542
114GRK50.34976395
115MAP3K120.34440147
116CSK0.33250273
117IKBKE0.33232745
118DDR20.32523980
119MAP3K20.32137447
120HCK0.31858103
121SYK0.31269790
122TRIB30.31216816
123RET0.30758781
124INSRR0.30622266
125CDK90.30557567
126CAMK10.30193335
127ABL20.30111345
128TRPM70.29608674
129TYK20.29565654
130TSSK60.29363288
131NEK90.28997396
132MAP3K10.27081887
133DYRK30.26546268
134MAP3K130.26172205
135CAMK1D0.24874537
136MTOR0.24353801
137AKT20.23934974
138ICK0.22339368
139TTN0.22329487
140CDK70.21806265
141EGFR0.21453039
142MELK0.20164379
143SRC0.20138548
144BRSK20.19932906
145HIPK20.19148652
146IKBKB0.19135783
147IRAK40.19023536
148PDPK10.18623522
149CCNB10.18573531
150CDK60.17709511
151ABL10.17619307
152SGK30.17287131
153MAPK150.17273602
154MAPKAPK20.16836891
155PRKCE0.16613949
156CDK30.15757566
157NEK20.14942390
158DMPK0.14222960

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.92079414
2Leukocyte transendothelial migration_Homo sapiens_hsa046702.72324176
3Caffeine metabolism_Homo sapiens_hsa002322.66261242
4Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.57743942
5Platelet activation_Homo sapiens_hsa046112.29240247
6ECM-receptor interaction_Homo sapiens_hsa045122.13923546
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.00354537
8Focal adhesion_Homo sapiens_hsa045101.95666235
9DNA replication_Homo sapiens_hsa030301.87494247
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.78622386
11Rap1 signaling pathway_Homo sapiens_hsa040151.78500501
12Notch signaling pathway_Homo sapiens_hsa043301.70476045
13Dorso-ventral axis formation_Homo sapiens_hsa043201.68446175
14Adherens junction_Homo sapiens_hsa045201.62339404
15Hematopoietic cell lineage_Homo sapiens_hsa046401.61683526
16Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.59337299
17Transcriptional misregulation in cancer_Homo sapiens_hsa052021.57630291
18Malaria_Homo sapiens_hsa051441.50671692
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48810213
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42436399
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40693113
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.40295357
23PI3K-Akt signaling pathway_Homo sapiens_hsa041511.39625202
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.39456443
25Viral myocarditis_Homo sapiens_hsa054161.38487679
26Small cell lung cancer_Homo sapiens_hsa052221.36466776
27Complement and coagulation cascades_Homo sapiens_hsa046101.36248999
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34653403
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31067328
30Pertussis_Homo sapiens_hsa051331.26289803
31Arginine biosynthesis_Homo sapiens_hsa002201.25836629
32Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.21789214
33Hippo signaling pathway_Homo sapiens_hsa043901.20471234
34Prion diseases_Homo sapiens_hsa050201.17990425
35Phospholipase D signaling pathway_Homo sapiens_hsa040721.17881781
36Herpes simplex infection_Homo sapiens_hsa051681.17400307
37Base excision repair_Homo sapiens_hsa034101.13938168
38Pathways in cancer_Homo sapiens_hsa052001.12620815
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.11199728
40Estrogen signaling pathway_Homo sapiens_hsa049151.11134316
41Gap junction_Homo sapiens_hsa045401.10864054
42Leishmaniasis_Homo sapiens_hsa051401.09977473
43Sphingolipid metabolism_Homo sapiens_hsa006001.06679941
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.05534756
45Proteoglycans in cancer_Homo sapiens_hsa052051.05031563
46Toxoplasmosis_Homo sapiens_hsa051451.04642343
47African trypanosomiasis_Homo sapiens_hsa051431.03903875
48Thyroid cancer_Homo sapiens_hsa052161.03221466
49B cell receptor signaling pathway_Homo sapiens_hsa046621.00495436
50Salmonella infection_Homo sapiens_hsa051321.00327278
51Tight junction_Homo sapiens_hsa045300.99703830
52Shigellosis_Homo sapiens_hsa051310.98164542
53Ras signaling pathway_Homo sapiens_hsa040140.97298918
54Hepatitis C_Homo sapiens_hsa051600.94573918
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94526934
56TGF-beta signaling pathway_Homo sapiens_hsa043500.94400699
57VEGF signaling pathway_Homo sapiens_hsa043700.93977929
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92751890
59Primary immunodeficiency_Homo sapiens_hsa053400.89306001
60Pyrimidine metabolism_Homo sapiens_hsa002400.89280911
61Dilated cardiomyopathy_Homo sapiens_hsa054140.88323884
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86562773
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86074644
64Calcium signaling pathway_Homo sapiens_hsa040200.85119533
65HIF-1 signaling pathway_Homo sapiens_hsa040660.82958899
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.82882947
67TNF signaling pathway_Homo sapiens_hsa046680.82811137
68Glutamatergic synapse_Homo sapiens_hsa047240.81700604
69Hedgehog signaling pathway_Homo sapiens_hsa043400.79725358
70Gastric acid secretion_Homo sapiens_hsa049710.79050949
71Renin secretion_Homo sapiens_hsa049240.78109680
72Bladder cancer_Homo sapiens_hsa052190.76516486
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76336427
74Oxytocin signaling pathway_Homo sapiens_hsa049210.76242059
75Glioma_Homo sapiens_hsa052140.76007420
76GnRH signaling pathway_Homo sapiens_hsa049120.75980509
77Basal cell carcinoma_Homo sapiens_hsa052170.75538400
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75389405
79Legionellosis_Homo sapiens_hsa051340.75344579
80Mismatch repair_Homo sapiens_hsa034300.75267421
81Phototransduction_Homo sapiens_hsa047440.75232381
82Bile secretion_Homo sapiens_hsa049760.74989271
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73812842
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72893077
85cAMP signaling pathway_Homo sapiens_hsa040240.71960153
86HTLV-I infection_Homo sapiens_hsa051660.71495374
87MicroRNAs in cancer_Homo sapiens_hsa052060.70932301
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70453268
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69882296
90Renal cell carcinoma_Homo sapiens_hsa052110.68252760
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.67280897
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67279316
93Glycerolipid metabolism_Homo sapiens_hsa005610.66786315
94Amoebiasis_Homo sapiens_hsa051460.66340672
95Measles_Homo sapiens_hsa051620.65945867
96N-Glycan biosynthesis_Homo sapiens_hsa005100.65707436
97Fatty acid elongation_Homo sapiens_hsa000620.64838103
98ErbB signaling pathway_Homo sapiens_hsa040120.63388327
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61469521
100Pancreatic cancer_Homo sapiens_hsa052120.61469201
101Spliceosome_Homo sapiens_hsa030400.61455925
102Wnt signaling pathway_Homo sapiens_hsa043100.59349682
103Influenza A_Homo sapiens_hsa051640.58516305
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57680941
105Chronic myeloid leukemia_Homo sapiens_hsa052200.56936095
106Purine metabolism_Homo sapiens_hsa002300.56335229
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56328484
108Fatty acid degradation_Homo sapiens_hsa000710.55403458
109Retinol metabolism_Homo sapiens_hsa008300.55325656
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54825324
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54659021
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54514514
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.54127224
114Protein digestion and absorption_Homo sapiens_hsa049740.53841523
115Choline metabolism in cancer_Homo sapiens_hsa052310.53144132
116Hepatitis B_Homo sapiens_hsa051610.52985193
117Osteoclast differentiation_Homo sapiens_hsa043800.52779483
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.52549598
119Arginine and proline metabolism_Homo sapiens_hsa003300.52306806
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.50171323
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49627462
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.49600765
123MAPK signaling pathway_Homo sapiens_hsa040100.49143268
124Lysine degradation_Homo sapiens_hsa003100.47072880
125Colorectal cancer_Homo sapiens_hsa052100.46850632
126Thyroid hormone synthesis_Homo sapiens_hsa049180.46515245
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44532031
128Ovarian steroidogenesis_Homo sapiens_hsa049130.43752805
129Homologous recombination_Homo sapiens_hsa034400.43581521
130RNA polymerase_Homo sapiens_hsa030200.43346018
131p53 signaling pathway_Homo sapiens_hsa041150.42792669
132Circadian entrainment_Homo sapiens_hsa047130.42458336
133Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42352085
134ABC transporters_Homo sapiens_hsa020100.42095392
135Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41518041
136Taste transduction_Homo sapiens_hsa047420.41199593
137Salivary secretion_Homo sapiens_hsa049700.40500328
138Melanogenesis_Homo sapiens_hsa049160.40469291
139Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40243656
140GABAergic synapse_Homo sapiens_hsa047270.39144241
141Glucagon signaling pathway_Homo sapiens_hsa049220.38605581
142Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38339837
143Circadian rhythm_Homo sapiens_hsa047100.38083672
144Insulin resistance_Homo sapiens_hsa049310.37443553
145SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37413257
146Neurotrophin signaling pathway_Homo sapiens_hsa047220.37295327
147NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37200226
148Galactose metabolism_Homo sapiens_hsa000520.36966586
149Drug metabolism - other enzymes_Homo sapiens_hsa009830.35916191
150Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34158891
151Fanconi anemia pathway_Homo sapiens_hsa034600.33234624
152Melanoma_Homo sapiens_hsa052180.32053922
153Endocytosis_Homo sapiens_hsa041440.31044513
154Axon guidance_Homo sapiens_hsa043600.30985104
155Cyanoamino acid metabolism_Homo sapiens_hsa004600.29429201

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