THSD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)6.68649975
2polyketide metabolic process (GO:0030638)6.68649975
3doxorubicin metabolic process (GO:0044598)6.68649975
4hemidesmosome assembly (GO:0031581)6.21870729
5desmosome organization (GO:0002934)5.36644182
6bone trabecula formation (GO:0060346)5.21083748
7lateral sprouting from an epithelium (GO:0060601)4.70578020
8bundle of His cell to Purkinje myocyte communication (GO:0086069)4.45852847
9cell proliferation involved in metanephros development (GO:0072203)4.34109981
10notochord development (GO:0030903)4.30829443
11regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.27986118
12cell-substrate junction assembly (GO:0007044)4.27031085
13aminoglycoside antibiotic metabolic process (GO:0030647)4.07425044
14negative regulation of epidermis development (GO:0045683)4.06273101
15cell adhesion mediated by integrin (GO:0033627)3.99510915
16somite rostral/caudal axis specification (GO:0032525)3.98511384
17skin morphogenesis (GO:0043589)3.93194798
18head development (GO:0060322)3.88062880
19regulation of mammary gland epithelial cell proliferation (GO:0033599)3.73581078
20regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.70998716
21cell proliferation involved in kidney development (GO:0072111)3.69631369
22regulation of non-canonical Wnt signaling pathway (GO:2000050)3.60570885
23branching involved in mammary gland duct morphogenesis (GO:0060444)3.53338825
24regulation of response to osmotic stress (GO:0047484)3.52571472
25sarcomere organization (GO:0045214)3.51638066
26planar cell polarity pathway involved in neural tube closure (GO:0090179)3.49372645
27atrioventricular valve morphogenesis (GO:0003181)3.47873393
28regulation of apoptotic process involved in morphogenesis (GO:1902337)3.42642745
29endocardial cushion development (GO:0003197)3.41353744
30positive regulation of smoothened signaling pathway (GO:0045880)3.40655840
31endodermal cell differentiation (GO:0035987)3.38179477
32positive regulation of DNA-dependent DNA replication (GO:2000105)3.37177948
33regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.35622487
34regulation of cardioblast differentiation (GO:0051890)3.34278456
35maintenance of protein location in nucleus (GO:0051457)3.32839892
36dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.31767761
37epithelial cell-cell adhesion (GO:0090136)3.21844902
38primitive streak formation (GO:0090009)3.21067635
39mesenchymal cell proliferation (GO:0010463)3.20780792
40protein heterotrimerization (GO:0070208)3.18762747
41metanephric mesenchyme development (GO:0072075)3.18574071
42negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.17828996
43glomerular basement membrane development (GO:0032836)3.17388355
44mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.15014329
45negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.14832299
46phenol-containing compound catabolic process (GO:0019336)3.14535556
47type B pancreatic cell proliferation (GO:0044342)3.13950253
48positive regulation of odontogenesis (GO:0042482)3.10914190
49focal adhesion assembly (GO:0048041)3.08921325
50cell-substrate adherens junction assembly (GO:0007045)3.08921325
51regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.04081891
52paraxial mesoderm development (GO:0048339)3.02431912
53adherens junction assembly (GO:0034333)3.02360408
54collagen fibril organization (GO:0030199)3.00518688
55regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.00114631
56negative regulation of axon extension involved in axon guidance (GO:0048843)2.99468849
57bone morphogenesis (GO:0060349)2.99171867
58cardiac myofibril assembly (GO:0055003)2.97279657
59convergent extension (GO:0060026)2.94888200
60anterior/posterior axis specification (GO:0009948)2.91203393
61kidney mesenchyme development (GO:0072074)2.90955570
62vascular endothelial growth factor signaling pathway (GO:0038084)2.90461409
63negative regulation of fatty acid transport (GO:2000192)2.89947588
64regulation of transforming growth factor beta2 production (GO:0032909)2.89454807
65negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.89356143
66regulation of nuclear cell cycle DNA replication (GO:0033262)2.87722714
67endothelial cell morphogenesis (GO:0001886)2.86461124
68regulation of axon extension involved in axon guidance (GO:0048841)2.86457357
69negative regulation of smoothened signaling pathway (GO:0045879)2.85651437
70muscle organ morphogenesis (GO:0048644)2.85548182
71retina vasculature morphogenesis in camera-type eye (GO:0061299)2.85518854
72regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.84987062
73embryonic forelimb morphogenesis (GO:0035115)2.84368201
74regulation of the force of heart contraction (GO:0002026)2.81516240
75regulation of odontogenesis (GO:0042481)2.81297510
76polarized epithelial cell differentiation (GO:0030859)2.79566709
77cellular response to vitamin (GO:0071295)2.79380066
78sequestering of extracellular ligand from receptor (GO:0035581)2.78154245
79substrate-dependent cell migration (GO:0006929)2.77436611
80* extracellular matrix assembly (GO:0085029)2.77181604
81cellular response to vitamin D (GO:0071305)2.77052822
82pericardium development (GO:0060039)2.76592520
83gap junction assembly (GO:0016264)2.75958516
84proximal/distal pattern formation (GO:0009954)2.75406471
85Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.75124598
86branching involved in salivary gland morphogenesis (GO:0060445)2.72954726
87Golgi transport vesicle coating (GO:0048200)2.72844128
88COPI coating of Golgi vesicle (GO:0048205)2.72844128
89renal filtration (GO:0097205)2.72508752
90actomyosin structure organization (GO:0031032)2.71729326
91negative regulation of keratinocyte proliferation (GO:0010839)2.71541565
92embryonic skeletal joint morphogenesis (GO:0060272)2.70525171
93regulation of MHC class I biosynthetic process (GO:0045343)2.70439043
94negative regulation of protein localization to cell surface (GO:2000009)2.70190600
95negative regulation of systemic arterial blood pressure (GO:0003085)2.70116274
96regulation of establishment of planar polarity (GO:0090175)2.69983112
97hindlimb morphogenesis (GO:0035137)2.68542088
98negative regulation of cell cycle G2/M phase transition (GO:1902750)2.68539341
99regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.68288078
100regulation of telomere maintenance via telomerase (GO:0032210)2.67860189
101lung lobe morphogenesis (GO:0060463)2.66165970
102embryonic hindlimb morphogenesis (GO:0035116)2.66142140
103insulin-like growth factor receptor signaling pathway (GO:0048009)2.66022760
104establishment of planar polarity (GO:0001736)2.65871091
105establishment of tissue polarity (GO:0007164)2.65871091
106lung vasculature development (GO:0060426)2.65862558
107hypotonic response (GO:0006971)2.65717960
108regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.62703499
109mesenchymal-epithelial cell signaling (GO:0060638)2.62576403
110cell migration involved in sprouting angiogenesis (GO:0002042)2.61181256
111mammary gland development (GO:0030879)2.59907680
112negative regulation of epidermal cell differentiation (GO:0045605)2.59817966
113forelimb morphogenesis (GO:0035136)2.59537292
114semaphorin-plexin signaling pathway (GO:0071526)2.59384312
115embryonic appendage morphogenesis (GO:0035113)2.59113724
116embryonic limb morphogenesis (GO:0030326)2.59113724
117lymphangiogenesis (GO:0001946)2.59001479
118cytoskeletal anchoring at plasma membrane (GO:0007016)2.57330206
119negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.56764883
120regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.55755647
121cell fate commitment involved in formation of primary germ layer (GO:0060795)2.55322768
122regulation of pigment cell differentiation (GO:0050932)2.55068844
123hair follicle morphogenesis (GO:0031069)2.54962615
124collagen metabolic process (GO:0032963)2.54399877
125extracellular matrix disassembly (GO:0022617)2.53827599
126regulation of morphogenesis of a branching structure (GO:0060688)2.53349687
127body morphogenesis (GO:0010171)2.52497599
128branching involved in labyrinthine layer morphogenesis (GO:0060670)2.52325488
129signal transduction involved in regulation of gene expression (GO:0023019)2.52067218
130basement membrane organization (GO:0071711)2.52055100
131fibroblast migration (GO:0010761)2.51570497
132smooth muscle tissue development (GO:0048745)2.51542281
133substrate adhesion-dependent cell spreading (GO:0034446)2.51264722
134embryonic skeletal system morphogenesis (GO:0048704)2.50087601
135mesenchyme morphogenesis (GO:0072132)2.50032270
136endothelial cell chemotaxis (GO:0035767)2.49586960
137regulation of cell fate commitment (GO:0010453)2.49163503
138middle ear morphogenesis (GO:0042474)2.48850721
139chondrocyte proliferation (GO:0035988)2.48705585
140dorsal/ventral axis specification (GO:0009950)2.48558839
141mesodermal cell differentiation (GO:0048333)2.48227633
142interferon-gamma production (GO:0032609)2.47889188
143cell communication involved in cardiac conduction (GO:0086065)2.47625607
144non-canonical Wnt signaling pathway (GO:0035567)2.47608733
145muscle cell migration (GO:0014812)2.47333330
146cell junction assembly (GO:0034329)2.47173044
147heart valve morphogenesis (GO:0003179)2.46272107
148wound healing, spreading of epidermal cells (GO:0035313)2.46226780
149negative regulation of catenin import into nucleus (GO:0035414)2.46062414
150ventricular cardiac muscle cell action potential (GO:0086005)2.46034292
151histone H4-K8 acetylation (GO:0043982)2.44894097
152histone H4-K5 acetylation (GO:0043981)2.44894097
153limb morphogenesis (GO:0035108)2.44163047
154appendage morphogenesis (GO:0035107)2.44163047
155mesenchymal cell differentiation (GO:0048762)2.44133290
156nephron epithelium morphogenesis (GO:0072088)2.43961012
157nephron tubule morphogenesis (GO:0072078)2.43961012
158negative regulation of chondrocyte differentiation (GO:0032331)2.43869049
159regulation of axon guidance (GO:1902667)2.43781335
160multicellular organismal macromolecule metabolic process (GO:0044259)2.43251746
161mesenchymal cell differentiation involved in kidney development (GO:0072161)2.42848785
162mesenchymal cell differentiation involved in renal system development (GO:2001012)2.42848785
163embryonic pattern specification (GO:0009880)2.42022217
164positive regulation of osteoblast proliferation (GO:0033690)2.41151471
165regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.41118634
166diterpenoid biosynthetic process (GO:0016102)2.40957354
167collagen catabolic process (GO:0030574)2.40505514
168organ induction (GO:0001759)2.40146037
169axon extension involved in axon guidance (GO:0048846)2.39680436
170neuron projection extension involved in neuron projection guidance (GO:1902284)2.39680436
171actin filament depolymerization (GO:0030042)2.38953868
172embryonic axis specification (GO:0000578)2.38893256
173negative regulation of cell fate commitment (GO:0010454)2.38461630
174positive regulation of bone mineralization (GO:0030501)2.37492798
175cell migration involved in heart development (GO:0060973)2.37283885
176outflow tract septum morphogenesis (GO:0003148)2.37255047
177craniofacial suture morphogenesis (GO:0097094)2.36796670
178cochlea morphogenesis (GO:0090103)2.36617319
179positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.35436406
180cardiac cell development (GO:0055006)2.35175619
181wound healing, spreading of cells (GO:0044319)2.34837777

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.90661297
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.11955762
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.11955762
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.11955762
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.61452288
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.33978704
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.15722128
8RARG_19884340_ChIP-ChIP_MEFs_Mouse3.12224156
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.64926195
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.29910400
11SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.17843052
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14087007
13CJUN_26792858_Chip-Seq_BT549_Human2.10415561
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.07508946
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.07508946
16ZNF263_19887448_ChIP-Seq_K562_Human2.04459433
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.99544024
18BMI1_23680149_ChIP-Seq_NPCS_Mouse1.99196643
19SOX9_24532713_ChIP-Seq_HFSC_Mouse1.92601047
20SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.90578867
21SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.87545815
22SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.87545815
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86998601
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.85857716
25PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.85565196
26CLOCK_20551151_ChIP-Seq_293T_Human1.83153788
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.82799270
28* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.81506127
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.80934781
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.80121863
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.79140499
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.78890921
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.75724947
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75008090
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.74758685
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.73466151
37RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.71926851
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.71924674
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.69088963
40* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69063490
41EZH2_22144423_ChIP-Seq_EOC_Human1.68753829
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.67576758
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67029142
44GBX2_23144817_ChIP-Seq_PC3_Human1.65991254
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65480869
46TBX20_22328084_ChIP-Seq_HEART_Mouse1.64326974
47TBX20_22080862_ChIP-Seq_HEART_Mouse1.64326974
48RING1B_27294783_Chip-Seq_NPCs_Mouse1.63921992
49CDX2_20551321_ChIP-Seq_CACO-2_Human1.63582269
50RNF2_27304074_Chip-Seq_NSC_Mouse1.61999987
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.60633891
52IGF1R_20145208_ChIP-Seq_DFB_Human1.54247828
53TP63_17297297_ChIP-ChIP_HaCaT_Human1.53761787
54* GATA2_21666600_ChIP-Seq_HMVEC_Human1.52308752
55TCF3_18692474_ChIP-Seq_MESCs_Mouse1.51689844
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50405614
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50312517
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50135355
59EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49615082
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48534622
61TP53_20018659_ChIP-ChIP_R1E_Mouse1.45145695
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.44840331
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44089637
64AHR_22903824_ChIP-Seq_MCF-7_Human1.43316459
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42293352
66TP53_16413492_ChIP-PET_HCT116_Human1.41775726
67* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39065012
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.38752868
69NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.37643729
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.35949942
71CTNNB1_20460455_ChIP-Seq_HCT116_Human1.34931894
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34621248
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.33129144
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.31477200
75RACK7_27058665_Chip-Seq_MCF-7_Human1.30461275
76* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.30211653
77TRIM28_21343339_ChIP-Seq_HEK293_Human1.29875890
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28823277
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28823277
80ISL1_27105846_Chip-Seq_CPCs_Mouse1.28223673
81SMAD3_21741376_ChIP-Seq_HESCs_Human1.28110085
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.26747752
83NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.26675039
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26241442
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24630198
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23748215
87* SOX2_20726797_ChIP-Seq_SW620_Human1.23622982
88FOXO3_23340844_ChIP-Seq_DLD1_Human1.22341033
89* RUNX1_27514584_Chip-Seq_MCF-7_Human1.22265902
90UBF1/2_26484160_Chip-Seq_HMECs_Human1.21746889
91P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21351465
92TP53_23651856_ChIP-Seq_MEFs_Mouse1.20338031
93* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19519007
94VDR_22108803_ChIP-Seq_LS180_Human1.19318325
95TCF3_18692474_ChIP-Seq_MEFs_Mouse1.19237271
96MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19047728
97* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18975790
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.17496340
99TP53_22127205_ChIP-Seq_IMR90_Human1.17116697
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.16744887
101* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16430445
102* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.16333801
103ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15833440
104MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.14826774
105SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14170100
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13390638
107ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13102255
108HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12901355
109STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12812118
110JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11018869
111RING1B_27294783_Chip-Seq_ESCs_Mouse1.10903107
112PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.10409378
113* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10311915
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09284315
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08990221
116JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07140541
117* EZH2_27294783_Chip-Seq_ESCs_Mouse1.06876224
118* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06784378
119RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06499350
120* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06119815
121TP63_23658742_ChIP-Seq_EP156T_Human1.05297151
122* TP53_18474530_ChIP-ChIP_U2OS_Human1.05251732
123TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05207898
124NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04927113
125ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04921844
126RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03082202
127* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02678476
128TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01018693
129TCF4_18268006_ChIP-ChIP_LS174T_Human1.00689626
130EP300_21415370_ChIP-Seq_HL-1_Mouse0.99942010
131IRF1_19129219_ChIP-ChIP_H3396_Human0.99631077
132* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98447690
133UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97640820
134NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96997590
135BRD4_25478319_ChIP-Seq_HGPS_Human0.96283178
136* ESR1_20079471_ChIP-ChIP_T-47D_Human0.96229322
137SMAD_19615063_ChIP-ChIP_OVARY_Human0.96148560
138KLF5_25053715_ChIP-Seq_YYC3_Human0.96131100
139SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95967374
140FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95750499
141NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95695282
142ATF3_27146783_Chip-Seq_COLON_Human0.95608085
143* SMAD4_21799915_ChIP-Seq_A2780_Human0.95497637
144PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95444124
145SMAD4_21741376_ChIP-Seq_HESCs_Human0.94992410
146* GATA3_24758297_ChIP-Seq_MCF-7_Human0.94719048
147ESR1_21235772_ChIP-Seq_MCF-7_Human0.94703196
148DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94282900
149* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93490909
150TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93324827
151EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92846946
152RXR_22108803_ChIP-Seq_LS180_Human0.92229361
153TET1_21490601_ChIP-Seq_MESCs_Mouse0.91979048
154* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91387001
155* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91387001
156NANOG_16153702_ChIP-ChIP_HESCs_Human0.91230273
157ESR2_21235772_ChIP-Seq_MCF-7_Human0.90789790
158* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90145872
159* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90064436
160SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89660154

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.15530901
2MP0003705_abnormal_hypodermis_morpholog3.64742712
3MP0006292_abnormal_olfactory_placode3.08707303
4MP0010030_abnormal_orbit_morphology3.01388477
5MP0000751_myopathy2.98899562
6MP0003566_abnormal_cell_adhesion2.86893264
7MP0000566_synostosis2.82078392
8MP0004264_abnormal_extraembryonic_tissu2.64611778
9MP0004084_abnormal_cardiac_muscle2.62110720
10MP0003121_genomic_imprinting2.61787708
11MP0000579_abnormal_nail_morphology2.50105153
12MP0005257_abnormal_intraocular_pressure2.48684868
13MP0003279_aneurysm2.48214402
14MP0003890_abnormal_embryonic-extraembry2.36155635
15MP0000049_abnormal_middle_ear2.32901878
16MP0005394_taste/olfaction_phenotype2.27107747
17MP0005499_abnormal_olfactory_system2.27107747
18MP0005503_abnormal_tendon_morphology2.26864889
19MP0009384_cardiac_valve_regurgitation2.22345950
20MP0000762_abnormal_tongue_morphology2.19474281
21MP0003950_abnormal_plasma_membrane2.16840535
22MP0009250_abnormal_appendicular_skeleto2.16728188
23MP0002938_white_spotting2.11764949
24MP0004272_abnormal_basement_membrane2.11522868
25MP0009780_abnormal_chondrocyte_physiolo2.10809734
26MP0000678_abnormal_parathyroid_gland2.07971128
27MP0003938_abnormal_ear_development2.07186672
28MP0003942_abnormal_urinary_system2.04067106
29MP0002060_abnormal_skin_morphology1.96518882
30MP0003941_abnormal_skin_development1.94300054
31MP0002233_abnormal_nose_morphology1.92743883
32MP0005248_abnormal_Harderian_gland1.92314349
33MP0002932_abnormal_joint_morphology1.90395971
34MP0003937_abnormal_limbs/digits/tail_de1.80251577
35MP0003385_abnormal_body_wall1.80187071
36MP0005023_abnormal_wound_healing1.79973890
37MP0002254_reproductive_system_inflammat1.79186187
38MP0003935_abnormal_craniofacial_develop1.77818735
39MP0002249_abnormal_larynx_morphology1.77764598
40MP0004858_abnormal_nervous_system1.77367628
41MP0003755_abnormal_palate_morphology1.75257277
42MP0003123_paternal_imprinting1.71383528
43MP0006138_congestive_heart_failure1.70524142
44MP0000428_abnormal_craniofacial_morphol1.68578136
45MP0005508_abnormal_skeleton_morphology1.67973803
46MP0005409_darkened_coat_color1.67168167
47MP0005623_abnormal_meninges_morphology1.64088808
48MP0001293_anophthalmia1.63650169
49MP0000467_abnormal_esophagus_morphology1.63313264
50MP0000534_abnormal_ureter_morphology1.60907364
51MP0000432_abnormal_head_morphology1.60695177
52MP0004036_abnormal_muscle_relaxation1.59378496
53MP0003787_abnormal_imprinting1.57983705
54MP0000013_abnormal_adipose_tissue1.56324921
55MP0000537_abnormal_urethra_morphology1.55731336
56MP0002116_abnormal_craniofacial_bone1.55638527
57MP0005330_cardiomyopathy1.55503824
58MP0002796_impaired_skin_barrier1.48454960
59MP0003091_abnormal_cell_migration1.45898823
60MP0002896_abnormal_bone_mineralization1.42924063
61MP0002277_abnormal_respiratory_mucosa1.41565298
62MP0008789_abnormal_olfactory_epithelium1.41375796
63MP0008438_abnormal_cutaneous_collagen1.40535636
64MP0001346_abnormal_lacrimal_gland1.39525473
65MP0001879_abnormal_lymphatic_vessel1.38599651
66MP0003011_delayed_dark_adaptation1.37095416
67MP0010368_abnormal_lymphatic_system1.37072591
68MP0002109_abnormal_limb_morphology1.35170735
69MP0006054_spinal_hemorrhage1.32399468
70MP0004215_abnormal_myocardial_fiber1.30216474
71MP0010352_gastrointestinal_tract_polyps1.29824351
72MP0000749_muscle_degeneration1.29672511
73MP0005377_hearing/vestibular/ear_phenot1.28949155
74MP0003878_abnormal_ear_physiology1.28949155
75MP0000733_abnormal_muscle_development1.26552398
76MP0010234_abnormal_vibrissa_follicle1.25959699
77MP0000516_abnormal_urinary_system1.25048685
78MP0005367_renal/urinary_system_phenotyp1.25048685
79MP0000163_abnormal_cartilage_morphology1.22731258
80MP0000538_abnormal_urinary_bladder1.21663208
81MP0002114_abnormal_axial_skeleton1.21640804
82MP0002092_abnormal_eye_morphology1.18199144
83MP0002108_abnormal_muscle_morphology1.17944112
84MP0005620_abnormal_muscle_contractility1.17515037
85MP0002877_abnormal_melanocyte_morpholog1.16782783
86MP0004087_abnormal_muscle_fiber1.16371831
87MP0002972_abnormal_cardiac_muscle1.15914124
88MP0005275_abnormal_skin_tensile1.15654999
89MP0005595_abnormal_vascular_smooth1.12767187
90MP0001270_distended_abdomen1.10895222
91MP0003315_abnormal_perineum_morphology1.10558529
92MP0001286_abnormal_eye_development1.10032889
93MP0000750_abnormal_muscle_regeneration1.09552897
94MP0005075_abnormal_melanosome_morpholog1.09455443
95MP0000613_abnormal_salivary_gland1.08118629
96MP0001849_ear_inflammation1.08004443
97MP0010630_abnormal_cardiac_muscle1.06606299
98MP0008775_abnormal_heart_ventricle1.06193145
99MP0005501_abnormal_skin_physiology1.05074850
100MP0001542_abnormal_bone_strength1.04751224
101MP0009053_abnormal_anal_canal1.03495782
102MP0010678_abnormal_skin_adnexa1.01896822
103MP0004782_abnormal_surfactant_physiolog1.01192809
104MP0003115_abnormal_respiratory_system1.01050123
105MP0003453_abnormal_keratinocyte_physiol1.00739354
106MP0000383_abnormal_hair_follicle1.00735189
107MP0003119_abnormal_digestive_system1.00045386
108MP0002925_abnormal_cardiovascular_devel0.99809004
109MP0002127_abnormal_cardiovascular_syste0.99030701
110MP0002697_abnormal_eye_size0.98373372
111MP0005670_abnormal_white_adipose0.97479144
112MP0000427_abnormal_hair_cycle0.97475823
113MP0000003_abnormal_adipose_tissue0.96762326
114MP0004510_myositis0.94660818
115MP0004233_abnormal_muscle_weight0.93716182
116MP0005076_abnormal_cell_differentiation0.93712790
117MP0003828_pulmonary_edema0.93379488
118MP0000759_abnormal_skeletal_muscle0.92668652
119MP0001348_abnormal_lacrimal_gland0.92456312
120MP0002098_abnormal_vibrissa_morphology0.91219967
121MP0005187_abnormal_penis_morphology0.90852416
122MP0010771_integument_phenotype0.89230877
123MP0001299_abnormal_eye_distance/0.88715794
124MP0004085_abnormal_heartbeat0.88281083
125MP0005165_increased_susceptibility_to0.87091542
126MP0001243_abnormal_dermal_layer0.86059405
127MP0000026_abnormal_inner_ear0.85896687
128MP0004484_altered_response_of0.84903396
129MP0002751_abnormal_autonomic_nervous0.83785031
130MP0002115_abnormal_skeleton_extremities0.83567491
131MP0005171_absent_coat_pigmentation0.82949827
132MP0002128_abnormal_blood_circulation0.82332459
133MP0001216_abnormal_epidermal_layer0.81809318
134MP0002085_abnormal_embryonic_tissue0.81600378
135MP0005385_cardiovascular_system_phenoty0.81127732
136MP0001544_abnormal_cardiovascular_syste0.81127732
137MP0000631_abnormal_neuroendocrine_gland0.81109312
138MP0000767_abnormal_smooth_muscle0.80406826
139MP0001958_emphysema0.80335936
140MP0010386_abnormal_urinary_bladder0.79909278
141MP0002269_muscular_atrophy0.79534512
142MP0002113_abnormal_skeleton_development0.78432348
143MP0002163_abnormal_gland_morphology0.76826188
144MP0003045_fibrosis0.76422424
145MP0002088_abnormal_embryonic_growth/wei0.76189152
146MP0005380_embryogenesis_phenotype0.76072260
147MP0001672_abnormal_embryogenesis/_devel0.76072260
148MP0001485_abnormal_pinna_reflex0.75320681
149MP0003984_embryonic_growth_retardation0.74291664
150MP0004145_abnormal_muscle_electrophysio0.74206793
151MP0001614_abnormal_blood_vessel0.74101423
152MP0002081_perinatal_lethality0.74095053
153MP0000627_abnormal_mammary_gland0.73947064
154MP0004134_abnormal_chest_morphology0.73785449
155MP0002177_abnormal_outer_ear0.72967806
156MP0002234_abnormal_pharynx_morphology0.72282321
157MP0003283_abnormal_digestive_organ0.71660604
158MP0002295_abnormal_pulmonary_circulatio0.71589238
159MP0005391_vision/eye_phenotype0.71448361
160MP0001175_abnormal_lung_morphology0.70937755
161MP0000462_abnormal_digestive_system0.70355863
162MP0003137_abnormal_impulse_conducting0.69541394

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.19419797
2Premature rupture of membranes (HP:0001788)5.07066173
3Hepatoblastoma (HP:0002884)4.69857178
4Aortic aneurysm (HP:0004942)4.44231890
5Aortic dissection (HP:0002647)4.38429806
6Right ventricular cardiomyopathy (HP:0011663)4.36100444
7Vascular tortuosity (HP:0004948)4.10011023
8Arterial tortuosity (HP:0005116)3.95544855
9Fragile skin (HP:0001030)3.55755318
10Partial duplication of the phalanx of hand (HP:0009999)3.55544991
11Partial duplication of thumb phalanx (HP:0009944)3.51784764
12Ankle contracture (HP:0006466)3.51743215
13Type 1 muscle fiber predominance (HP:0003803)3.36643561
14Nasolacrimal duct obstruction (HP:0000579)3.26685974
15Follicular hyperkeratosis (HP:0007502)3.26186120
16Abnormality of the distal phalanx of the thumb (HP:0009617)3.21763568
17Cervical subluxation (HP:0003308)3.21235109
18Bladder diverticulum (HP:0000015)3.17117717
19Spinal rigidity (HP:0003306)3.09890362
20Renal duplication (HP:0000075)3.04127101
21Abnormality of the lacrimal duct (HP:0011481)3.03732230
22Abnormality of the phalanges of the hallux (HP:0010057)3.03637616
23Sudden death (HP:0001699)3.00147896
24Ventricular tachycardia (HP:0004756)2.95845277
25Abnormality of the nasolacrimal system (HP:0000614)2.93096543
26Bifid tongue (HP:0010297)2.92508241
27Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.90731723
28Short 4th metacarpal (HP:0010044)2.90731723
29Wormian bones (HP:0002645)2.89391943
30Nephroblastoma (Wilms tumor) (HP:0002667)2.87732706
31Soft skin (HP:0000977)2.86008354
32Increased connective tissue (HP:0009025)2.78429519
33Milia (HP:0001056)2.74027859
34Embryonal renal neoplasm (HP:0011794)2.70836085
35Abnormality of dentin (HP:0010299)2.69524392
36Natal tooth (HP:0000695)2.67915000
37Bundle branch block (HP:0011710)2.67592218
38Rib fusion (HP:0000902)2.65950765
39Midline defect of the nose (HP:0004122)2.62006945
40Periauricular skin pits (HP:0100277)2.60082633
41Preauricular pit (HP:0004467)2.60082633
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.57852438
43Hyporeflexia of lower limbs (HP:0002600)2.56610816
44Distal lower limb muscle weakness (HP:0009053)2.56333191
45Aneurysm (HP:0002617)2.55904393
46Preaxial foot polydactyly (HP:0001841)2.52452884
47Short nail (HP:0001799)2.49943674
48Supernumerary ribs (HP:0005815)2.46976486
49Mesomelia (HP:0003027)2.46654452
50Cerebral aneurysm (HP:0004944)2.46264469
51Short middle phalanx of the 5th finger (HP:0004220)2.45394513
52Abnormality of the parietal bone (HP:0002696)2.40919571
53Aortic regurgitation (HP:0001659)2.37387933
54Hypochromic microcytic anemia (HP:0004840)2.35092272
55Overgrowth (HP:0001548)2.34993327
56Mitral valve prolapse (HP:0001634)2.34802914
57Broad face (HP:0000283)2.34228050
58Lipoatrophy (HP:0100578)2.33363576
59Abnormality of the pubic bones (HP:0003172)2.31763076
60Broad metatarsal (HP:0001783)2.31538292
61Rectovaginal fistula (HP:0000143)2.30801205
62Rectal fistula (HP:0100590)2.30801205
63Joint laxity (HP:0001388)2.28694653
64Atrial fibrillation (HP:0005110)2.28065663
65Osteolytic defects of the hand bones (HP:0009699)2.26518685
66Osteolytic defects of the phalanges of the hand (HP:0009771)2.26518685
67Fragile nails (HP:0001808)2.26280936
68Skin pits (HP:0100276)2.25593561
69Cutaneous finger syndactyly (HP:0010554)2.24652623
70Increased variability in muscle fiber diameter (HP:0003557)2.24208876
71Alopecia of scalp (HP:0002293)2.20797832
72Chromsome breakage (HP:0040012)2.20343378
73Broad toe (HP:0001837)2.20143615
74Long toe (HP:0010511)2.19530290
75Intestinal fistula (HP:0100819)2.17574607
76Abnormal lung lobation (HP:0002101)2.17060026
77Duplication of thumb phalanx (HP:0009942)2.15694757
78Supernumerary bones of the axial skeleton (HP:0009144)2.15681549
79Advanced eruption of teeth (HP:0006288)2.15005323
80Asymmetric septal hypertrophy (HP:0001670)2.12124673
81Blue sclerae (HP:0000592)2.11083971
82Abnormality of the pulmonary veins (HP:0011718)2.10829289
83Shallow orbits (HP:0000586)2.10794073
84Fused cervical vertebrae (HP:0002949)2.10075940
85Abnormality of the calf musculature (HP:0001430)2.09932422
86Mitral regurgitation (HP:0001653)2.07974454
87Elbow flexion contracture (HP:0002987)2.06836000
88Abnormality of the 4th metacarpal (HP:0010012)2.06822598
89Short middle phalanx of finger (HP:0005819)2.06350463
90Dilatation of the ascending aorta (HP:0005111)2.06193353
91Spondylolisthesis (HP:0003302)2.05280827
92Atrophic scars (HP:0001075)2.04977917
93Anomalous pulmonary venous return (HP:0010772)2.03007450
94Wrist flexion contracture (HP:0001239)2.02220306
95Short 5th finger (HP:0009237)2.01145730
96Abnormality of the right ventricle (HP:0001707)2.00204036
97Pterygium (HP:0001059)1.98566107
98Hypoplasia of the fovea (HP:0007750)1.98403733
99Aplasia/Hypoplasia of the fovea (HP:0008060)1.98403733
100Ectopic anus (HP:0004397)1.98215604
101Bradycardia (HP:0001662)1.97562334
102Hypoplastic labia majora (HP:0000059)1.95314276
103Bronchomalacia (HP:0002780)1.95270646
104Syncope (HP:0001279)1.94248542
105Hydroureter (HP:0000072)1.94216999
106Pulmonary artery stenosis (HP:0004415)1.93849451
107Vaginal fistula (HP:0004320)1.93697834
108Neonatal short-limb short stature (HP:0008921)1.93348089
109Primary atrial arrhythmia (HP:0001692)1.92740072
110Cutaneous syndactyly (HP:0012725)1.92267600
111Mitral stenosis (HP:0001718)1.91383118
112Genu recurvatum (HP:0002816)1.90979667
113Mildly elevated creatine phosphokinase (HP:0008180)1.89944013
114Tibial bowing (HP:0002982)1.89439911
115Facial cleft (HP:0002006)1.88209827
116Distal lower limb amyotrophy (HP:0008944)1.87885028
117Selective tooth agenesis (HP:0001592)1.87088873
118Shawl scrotum (HP:0000049)1.86875052
119Neoplasm of the heart (HP:0100544)1.86364088
120Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.86135087
121Neoplasm of striated muscle (HP:0009728)1.85516077
122Hypoventilation (HP:0002791)1.84994368
123Broad thumb (HP:0011304)1.84728748
124Vertebral compression fractures (HP:0002953)1.83937072
125Abnormality of nail color (HP:0100643)1.83576530
126Abnormality of the acetabulum (HP:0003170)1.83139469
127Protrusio acetabuli (HP:0003179)1.82733064
128Supraventricular tachycardia (HP:0004755)1.82596629
129Supraventricular arrhythmia (HP:0005115)1.81951238
130Preauricular skin tag (HP:0000384)1.81856744
131Wide anterior fontanel (HP:0000260)1.79855394
132Abnormality of skeletal muscle fiber size (HP:0012084)1.79266722
133Aortic valve stenosis (HP:0001650)1.79093356
134Abnormal atrioventricular conduction (HP:0005150)1.78467252
135Abnormality of the labia majora (HP:0012881)1.78272741
136Knee flexion contracture (HP:0006380)1.77125921
137Onycholysis (HP:0001806)1.76601120
138Plantar hyperkeratosis (HP:0007556)1.75251368
139Large earlobe (HP:0009748)1.75094520
140Short humerus (HP:0005792)1.74621043
141Trigonocephaly (HP:0000243)1.74540055
142Abnormality of the nasal septum (HP:0000419)1.74365545
143Slender build (HP:0001533)1.74075577
144Abnormality of the incisor (HP:0000676)1.73541743
145Increased number of teeth (HP:0011069)1.73366986
146Bowel diverticulosis (HP:0005222)1.73324791
147Meckel diverticulum (HP:0002245)1.72976132
148Dilated cardiomyopathy (HP:0001644)1.72194451
149Skin tags (HP:0010609)1.70183249
150Aplasia involving bones of the extremities (HP:0009825)1.69975604
151Aplasia involving bones of the upper limbs (HP:0009823)1.69975604
152Aplasia of the phalanges of the hand (HP:0009802)1.69975604
153Limited hip movement (HP:0008800)1.69393136
154Muscle fiber splitting (HP:0003555)1.69085720
155Osteomalacia (HP:0002749)1.69051849
156Hyperextensible skin (HP:0000974)1.68655576
157Biconcave vertebral bodies (HP:0004586)1.68412500
158Dislocated radial head (HP:0003083)1.68256656
159Atresia of the external auditory canal (HP:0000413)1.67968095
160Lymphangioma (HP:0100764)1.67798875
161Thick nail (HP:0001805)1.67172555
162Protruding ear (HP:0000411)1.66844251
163Cardiovascular calcification (HP:0011915)1.66717178
164Upper limb amyotrophy (HP:0009129)1.66592068
165Distal upper limb amyotrophy (HP:0007149)1.66592068
166Generalized amyotrophy (HP:0003700)1.66421676
167Round ear (HP:0100830)1.66231476
168Testicular atrophy (HP:0000029)1.66210398
169Hypoplastic scapulae (HP:0000882)1.65461238
170Aplasia/Hypoplasia of the scapulae (HP:0006713)1.65461238
171Infantile muscular hypotonia (HP:0008947)1.65380440
172Ulnar bowing (HP:0003031)1.64488740
173Neonatal death (HP:0003811)1.64169587
174Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.63925185
175Abnormality of incisor morphology (HP:0011063)1.63327461
176Aplasia/hypoplasia of the humerus (HP:0006507)1.62415247
177Absent eyebrow (HP:0002223)1.61974042
178Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.61740285
179Coronal craniosynostosis (HP:0004440)1.61538735
180Abnormality of chromosome segregation (HP:0002916)1.61397044
181Abnormality of the radial head (HP:0003995)1.61255716
182Abnormality of the ileum (HP:0001549)1.60481597
183Renal hypoplasia (HP:0000089)1.60058071
184Absent frontal sinuses (HP:0002688)1.59930769
185Anophthalmia (HP:0000528)1.59614533
186Aplasia/Hypoplasia of the sternum (HP:0006714)1.58905429
187Embryonal neoplasm (HP:0002898)1.58182960
188Abnormality of the middle phalanges of the hand (HP:0009833)1.58171450
189Abnormality of the salivary glands (HP:0010286)1.58035698
190Dental malocclusion (HP:0000689)1.57808160

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.71515345
2GRK54.22444496
3TTN3.71996226
4ADRBK23.09356682
5MST1R3.09019294
6GRK12.83013586
7TRIB32.76218155
8TGFBR22.60916883
9EPHA22.55330583
10LATS12.49688975
11WNK12.34873944
12GRK62.24210424
13GRK72.18749002
14ERN12.14585943
15EPHA32.05399582
16MAPK72.00148669
17AKT31.95034800
18DDR21.92972398
19EPHB11.80003584
20EPHB21.62240098
21FER1.51157493
22MATK1.50871750
23CSF1R1.50129081
24CAMK41.44185404
25TTK1.42901282
26PAK21.42392493
27NTRK11.41670662
28TESK11.40972831
29MOS1.39334881
30LIMK11.39151746
31MAPKAPK31.38782808
32PKN21.38458577
33PRKG21.37604502
34CDK81.33774659
35NEK91.32349668
36ADRBK11.26652178
37NTRK31.25030932
38FGFR31.22182074
39PAK41.21594749
40FLT31.20585248
41EEF2K1.20252350
42BRD41.18175755
43EPHA41.16537213
44MUSK1.16207970
45ICK1.14833505
46DMPK1.13611490
47ROCK11.13440846
48PDGFRA1.12768613
49TYRO31.10490011
50HIPK21.09224170
51RPS6KA21.07181508
52NUAK11.05861657
53EIF2AK21.05219436
54MAP3K61.05156217
55CDK71.03517416
56STK38L0.99520816
57MARK20.98506659
58INSRR0.97963834
59PTK20.97160566
60PRPF4B0.96328665
61CHEK20.93858177
62ZAK0.93675008
63ROCK20.93657402
64RIPK10.93596595
65STK100.90976389
66ERBB40.90035620
67ERBB20.87239567
68FGFR10.83945078
69STK30.83662823
70STK240.81762899
71PTK2B0.76512173
72LATS20.74608600
73SIK10.74064137
74PRKD10.72997898
75FGFR20.71890299
76TGFBR10.69333343
77PTK60.68578334
78MAP3K70.67825210
79CAMK2G0.66872191
80IGF1R0.66621606
81ERBB30.66125346
82PIK3CG0.65982785
83SIK30.65177398
84ILK0.63702207
85CHUK0.63445860
86BCR0.59769275
87MELK0.59640321
88MAP3K30.59008371
89PAK30.58621160
90AKT20.58387372
91MAP2K10.57839819
92PRKCI0.55962789
93RPS6KC10.55104750
94RPS6KL10.55104750
95MARK10.54785593
96BMPR20.54277654
97CAMK2B0.51822360
98MTOR0.51343536
99MAP2K40.50606474
100PDGFRB0.49077653
101CLK10.48773984
102PLK20.48595194
103DYRK1A0.47292096
104INSR0.47058866
105PIK3CA0.47023305
106PRKCE0.46508304
107RET0.46027081
108CAMK1D0.45392857
109RPS6KA60.43481224
110CASK0.43369536
111MAPK100.42618078
112FGFR40.41997930
113YES10.41031801
114CDC42BPA0.40862495
115OBSCN0.40337795
116MAP3K20.39370463
117BMX0.39062096
118PRKAA10.37411321
119MYLK0.37065387
120MET0.36455541
121MAPKAPK20.36344888
122NEK60.35781066
123MST40.35626912
124STK380.34932239
125PIM20.34860957
126ABL20.34826849
127LMTK20.33766536
128PHKG20.33153797
129PHKG10.33153797
130PRKAA20.32951641
131RPS6KB20.32808411
132CAMK10.32762752
133DAPK30.32444196
134MAPK10.31366699
135SGK20.30813293
136MAPK150.30754931
137GSK3B0.30261300
138TRPM70.29633921
139TIE10.29382220
140GSK3A0.29095842
141PRKD20.28115486
142CAMK2D0.27718952
143CSNK1A10.27520091
144MAPK140.27294172
145CSK0.27248845
146CAMK1G0.27120704
147SCYL20.26979236
148MAP3K100.26940340
149IRAK30.26673355
150ARAF0.26488126

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.71602562
2Basal cell carcinoma_Homo sapiens_hsa052172.41473317
3ECM-receptor interaction_Homo sapiens_hsa045122.08589376
4Hedgehog signaling pathway_Homo sapiens_hsa043402.03239433
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.92778931
6Adherens junction_Homo sapiens_hsa045201.88484712
7Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.72518487
8Hippo signaling pathway_Homo sapiens_hsa043901.70300530
9Wnt signaling pathway_Homo sapiens_hsa043101.64764759
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.58050037
11Vitamin B6 metabolism_Homo sapiens_hsa007501.55765637
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.55041047
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.54854836
14Dilated cardiomyopathy_Homo sapiens_hsa054141.52690833
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.51585737
16Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.40802738
17Axon guidance_Homo sapiens_hsa043601.38752514
18Arachidonic acid metabolism_Homo sapiens_hsa005901.38553432
19Protein digestion and absorption_Homo sapiens_hsa049741.38225248
20Taste transduction_Homo sapiens_hsa047421.37697515
21Focal adhesion_Homo sapiens_hsa045101.34224718
22MicroRNAs in cancer_Homo sapiens_hsa052061.33417400
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.31114420
24Proteoglycans in cancer_Homo sapiens_hsa052051.29598974
25Pathways in cancer_Homo sapiens_hsa052001.29595576
26Regulation of actin cytoskeleton_Homo sapiens_hsa048101.21359912
27TGF-beta signaling pathway_Homo sapiens_hsa043501.18983900
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15746839
29Tight junction_Homo sapiens_hsa045301.13063195
30Rap1 signaling pathway_Homo sapiens_hsa040151.12449832
31Ovarian steroidogenesis_Homo sapiens_hsa049131.10498349
32Thyroid cancer_Homo sapiens_hsa052161.08259876
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07626047
34Small cell lung cancer_Homo sapiens_hsa052221.04778565
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.03807092
36cAMP signaling pathway_Homo sapiens_hsa040241.02272479
37Melanogenesis_Homo sapiens_hsa049161.00422173
38Vascular smooth muscle contraction_Homo sapiens_hsa042700.99759939
39Colorectal cancer_Homo sapiens_hsa052100.99461757
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98274706
41Serotonergic synapse_Homo sapiens_hsa047260.97877507
42Circadian rhythm_Homo sapiens_hsa047100.97821043
43Melanoma_Homo sapiens_hsa052180.97590660
44Notch signaling pathway_Homo sapiens_hsa043300.96944162
45PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94422071
46Calcium signaling pathway_Homo sapiens_hsa040200.93643549
47Renin secretion_Homo sapiens_hsa049240.93585666
48Bladder cancer_Homo sapiens_hsa052190.93195735
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93074237
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92161841
51Prostate cancer_Homo sapiens_hsa052150.91740678
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.91346413
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90074868
54Glutamatergic synapse_Homo sapiens_hsa047240.90020292
55Estrogen signaling pathway_Homo sapiens_hsa049150.86366466
56AMPK signaling pathway_Homo sapiens_hsa041520.86181927
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85758998
58Nicotine addiction_Homo sapiens_hsa050330.85355599
59Insulin resistance_Homo sapiens_hsa049310.85293849
60Pancreatic cancer_Homo sapiens_hsa052120.85164607
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83333166
62Long-term depression_Homo sapiens_hsa047300.81986332
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80937916
64Bile secretion_Homo sapiens_hsa049760.80546580
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.79379682
66Ras signaling pathway_Homo sapiens_hsa040140.79295911
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78948359
68Choline metabolism in cancer_Homo sapiens_hsa052310.77837211
69Fanconi anemia pathway_Homo sapiens_hsa034600.76409123
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76251229
71Circadian entrainment_Homo sapiens_hsa047130.76089162
72Endometrial cancer_Homo sapiens_hsa052130.75957963
73Renal cell carcinoma_Homo sapiens_hsa052110.75892114
74Mineral absorption_Homo sapiens_hsa049780.75102797
75Long-term potentiation_Homo sapiens_hsa047200.74071653
76Salivary secretion_Homo sapiens_hsa049700.73199307
77Fructose and mannose metabolism_Homo sapiens_hsa000510.72965006
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72425910
79Thyroid hormone synthesis_Homo sapiens_hsa049180.71527971
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.70910697
81ABC transporters_Homo sapiens_hsa020100.70683285
82Insulin signaling pathway_Homo sapiens_hsa049100.70366693
83Ether lipid metabolism_Homo sapiens_hsa005650.68902908
84GnRH signaling pathway_Homo sapiens_hsa049120.68783129
85Inositol phosphate metabolism_Homo sapiens_hsa005620.67325336
86PPAR signaling pathway_Homo sapiens_hsa033200.66930769
87African trypanosomiasis_Homo sapiens_hsa051430.66548788
88Sphingolipid metabolism_Homo sapiens_hsa006000.66536296
89Lysine degradation_Homo sapiens_hsa003100.66209219
90Oxytocin signaling pathway_Homo sapiens_hsa049210.65587285
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64468429
92ErbB signaling pathway_Homo sapiens_hsa040120.64280678
93MAPK signaling pathway_Homo sapiens_hsa040100.63641073
94mTOR signaling pathway_Homo sapiens_hsa041500.62734432
95Amoebiasis_Homo sapiens_hsa051460.62254173
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61897531
97HTLV-I infection_Homo sapiens_hsa051660.61342641
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60526501
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60478004
100Phenylalanine metabolism_Homo sapiens_hsa003600.60462734
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60364104
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59790086
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58668471
104Prion diseases_Homo sapiens_hsa050200.58555374
105Toxoplasmosis_Homo sapiens_hsa051450.58297408
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57433697
107Galactose metabolism_Homo sapiens_hsa000520.57176408
108Non-small cell lung cancer_Homo sapiens_hsa052230.57006918
109Gastric acid secretion_Homo sapiens_hsa049710.56528787
110Linoleic acid metabolism_Homo sapiens_hsa005910.56451698
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56110778
112Complement and coagulation cascades_Homo sapiens_hsa046100.55675619
113Insulin secretion_Homo sapiens_hsa049110.55569626
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54919338
115Cardiac muscle contraction_Homo sapiens_hsa042600.54893055
116GABAergic synapse_Homo sapiens_hsa047270.54467254
117Amphetamine addiction_Homo sapiens_hsa050310.53949711
118Pancreatic secretion_Homo sapiens_hsa049720.53384216
119Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52713677
120Chronic myeloid leukemia_Homo sapiens_hsa052200.52653983
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52014880
122Glucagon signaling pathway_Homo sapiens_hsa049220.51906201
123Cell cycle_Homo sapiens_hsa041100.50907921
124Glioma_Homo sapiens_hsa052140.50616744
125mRNA surveillance pathway_Homo sapiens_hsa030150.50319557
126VEGF signaling pathway_Homo sapiens_hsa043700.50096298
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49784575
128Dorso-ventral axis formation_Homo sapiens_hsa043200.49429554
129N-Glycan biosynthesis_Homo sapiens_hsa005100.47395819
130Gap junction_Homo sapiens_hsa045400.47030041
131Platelet activation_Homo sapiens_hsa046110.46590224
132Morphine addiction_Homo sapiens_hsa050320.46550534
133Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45982056
134RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45865850
135Endocytosis_Homo sapiens_hsa041440.42366588
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.40361859
137Cocaine addiction_Homo sapiens_hsa050300.40016427

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »