THSD7B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration in hindbrain (GO:0021535)7.17309148
2ganglion development (GO:0061548)6.59823836
3enteric nervous system development (GO:0048484)6.38010227
4neuromuscular synaptic transmission (GO:0007274)5.51738959
5mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)5.31571311
6positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021105.31571311
7dopaminergic neuron differentiation (GO:0071542)4.97251892
8synaptic transmission, cholinergic (GO:0007271)4.55568482
9pyrimidine nucleobase catabolic process (GO:0006208)4.23526935
10neuron cell-cell adhesion (GO:0007158)4.20213469
11positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)4.19024585
12positive regulation of cell cycle G2/M phase transition (GO:1902751)4.19024585
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.96292094
14activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.77072840
15opioid receptor signaling pathway (GO:0038003)3.74652610
16ionotropic glutamate receptor signaling pathway (GO:0035235)3.70225601
17lens morphogenesis in camera-type eye (GO:0002089)3.68479630
18cilium or flagellum-dependent cell motility (GO:0001539)3.58577032
19startle response (GO:0001964)3.58368332
20regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.56673700
21atrial cardiac muscle cell action potential (GO:0086014)3.52817666
22response to BMP (GO:0071772)3.47840004
23cellular response to BMP stimulus (GO:0071773)3.47840004
24peristalsis (GO:0030432)3.46406599
25G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.44087971
26glutamate receptor signaling pathway (GO:0007215)3.42447236
27microtubule depolymerization (GO:0007019)3.39118658
28positive regulation of dendritic spine morphogenesis (GO:0061003)3.38255053
29vocalization behavior (GO:0071625)3.37430729
30retinal cone cell development (GO:0046549)3.35373273
31regulation of DNA endoreduplication (GO:0032875)3.32227805
32regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.31168141
33limb bud formation (GO:0060174)3.27362999
34cornea development in camera-type eye (GO:0061303)3.23537863
35nucleobase catabolic process (GO:0046113)3.21771643
36regulation of glutamate receptor signaling pathway (GO:1900449)3.19994929
37nuclear pore complex assembly (GO:0051292)3.18688859
38positive regulation of mitochondrial membrane permeability (GO:0035794)3.18595031
39acrosome reaction (GO:0007340)3.18143790
40suckling behavior (GO:0001967)3.15463473
41righting reflex (GO:0060013)3.15350757
42serotonin receptor signaling pathway (GO:0007210)3.14934513
43cell differentiation in hindbrain (GO:0021533)3.13996618
44synaptic transmission, glutamatergic (GO:0035249)3.11887823
45dendritic spine morphogenesis (GO:0060997)3.10303400
46negative regulation of homotypic cell-cell adhesion (GO:0034111)3.08305536
47regulation of pigment cell differentiation (GO:0050932)3.07364388
48presynaptic membrane assembly (GO:0097105)3.05914019
49negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05686917
50synaptic vesicle endocytosis (GO:0048488)3.04082464
51neuronal ion channel clustering (GO:0045161)3.03555408
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.03326442
53regulation of respiratory system process (GO:0044065)2.99568273
54central nervous system projection neuron axonogenesis (GO:0021952)2.99011640
55neuron recognition (GO:0008038)2.97858132
56superoxide anion generation (GO:0042554)2.97234583
57behavioral response to nicotine (GO:0035095)2.94789179
58centriole assembly (GO:0098534)2.94387868
59positive regulation of developmental pigmentation (GO:0048087)2.94381240
60sympathetic nervous system development (GO:0048485)2.94252935
61negative regulation of dendrite morphogenesis (GO:0050774)2.93598499
62nerve growth factor signaling pathway (GO:0038180)2.93488634
63pre-miRNA processing (GO:0031054)2.93066684
64glycosphingolipid biosynthetic process (GO:0006688)2.91491836
65nuclear pore organization (GO:0006999)2.89791113
66neuron-neuron synaptic transmission (GO:0007270)2.89503517
67auditory behavior (GO:0031223)2.89177331
68cAMP catabolic process (GO:0006198)2.89175890
69layer formation in cerebral cortex (GO:0021819)2.88713065
70protein localization to cilium (GO:0061512)2.87741193
71epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.86381821
72protein localization to synapse (GO:0035418)2.86343518
73regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.85769584
74motile cilium assembly (GO:0044458)2.85291824
75behavioral response to ethanol (GO:0048149)2.85268899
76postsynaptic membrane organization (GO:0001941)2.84519894
77regulation of mRNA catabolic process (GO:0061013)2.83720233
78dendrite development (GO:0016358)2.81762708
79hindbrain development (GO:0030902)2.81656928
80regulation of cell cycle G2/M phase transition (GO:1902749)2.80427432
81multicellular organism reproduction (GO:0032504)2.79232625
82positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.78959184
83adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.78385306
84intraciliary transport (GO:0042073)2.76778309
85regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.75298222
86regulation of respiratory gaseous exchange (GO:0043576)2.74707517
87epithelial cilium movement (GO:0003351)2.72403073
88axonal fasciculation (GO:0007413)2.70746018
89cardiac ventricle formation (GO:0003211)2.70428925
90cerebral cortex radially oriented cell migration (GO:0021799)2.70344654
91DNA double-strand break processing (GO:0000729)2.69957204
92positive regulation of cellular amide metabolic process (GO:0034250)2.69533457
93cyclic nucleotide catabolic process (GO:0009214)2.69370250
94cilium movement (GO:0003341)2.68845273
95G-protein coupled receptor internalization (GO:0002031)2.67902814
96response to nicotine (GO:0035094)2.67146040
97gamma-aminobutyric acid signaling pathway (GO:0007214)2.66946058
98presynaptic membrane organization (GO:0097090)2.65107784
99DNA replication-dependent nucleosome assembly (GO:0006335)2.65052548
100DNA replication-dependent nucleosome organization (GO:0034723)2.65052548
101negative regulation of DNA-dependent DNA replication (GO:2000104)2.64200960
102negative regulation of cytosolic calcium ion concentration (GO:0051481)2.64043545
103negative regulation of dendrite development (GO:2000171)2.63881304
104cilium assembly (GO:0042384)2.62975608
105cardiac chamber formation (GO:0003207)2.62093927
106cerebellar Purkinje cell differentiation (GO:0021702)2.61728560
107regulation of cilium movement (GO:0003352)2.60094965
108telencephalon development (GO:0021537)2.59950861
109positive regulation of synapse assembly (GO:0051965)2.59804833
110centriole replication (GO:0007099)2.58208249
111negative regulation of translation, ncRNA-mediated (GO:0040033)2.57018179
112regulation of translation, ncRNA-mediated (GO:0045974)2.57018179
113negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.57018179
114regulation of synapse maturation (GO:0090128)2.56641719
115positive regulation of cardiac muscle cell differentiation (GO:2000727)2.56362018
116positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.56187011
117regulation of short-term neuronal synaptic plasticity (GO:0048172)2.55510232
118membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.53594372
119axonemal dynein complex assembly (GO:0070286)2.52291540
120central nervous system neuron axonogenesis (GO:0021955)2.52149123
121cranial nerve structural organization (GO:0021604)2.51693210
122cell proliferation in forebrain (GO:0021846)2.51584622
123positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.51514869
124synapse assembly (GO:0007416)2.51502109
125regulation of synaptic transmission, glutamatergic (GO:0051966)2.50491697
126olfactory bulb development (GO:0021772)2.50424498
127synaptic vesicle exocytosis (GO:0016079)2.50377963
128cilium organization (GO:0044782)2.49199109
129facial nerve structural organization (GO:0021612)2.49076844
130negative regulation of DNA recombination (GO:0045910)2.48847419
131microtubule anchoring (GO:0034453)2.48157753
132tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.47994639
133RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.47994639
134regulation of dendrite morphogenesis (GO:0048814)2.47760708
135transmission of nerve impulse (GO:0019226)2.46915520
136dentate gyrus development (GO:0021542)2.45995782
137gamma-aminobutyric acid transport (GO:0015812)2.45833191
138regulation of platelet aggregation (GO:0090330)2.45760391
139response to auditory stimulus (GO:0010996)2.45510622
140negative regulation of cell cycle arrest (GO:0071157)2.45133311
141axonogenesis (GO:0007409)2.43314047
142regulation of DNA methylation (GO:0044030)2.43194312
143phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200)2.42199385
144replication fork processing (GO:0031297)2.41323703
145spinal cord association neuron differentiation (GO:0021527)2.40998845
146kinetochore organization (GO:0051383)2.40241537
147regulation of synapse structural plasticity (GO:0051823)2.38406097
148positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.38214024
149cerebellum development (GO:0021549)2.37772379
150neurotransmitter-gated ion channel clustering (GO:0072578)2.36728737
151regulation of synapse assembly (GO:0051963)2.33851977
152membrane depolarization during action potential (GO:0086010)2.32128693
153neuronal action potential (GO:0019228)2.32004720
154kidney morphogenesis (GO:0060993)2.31246717
155behavioral response to pain (GO:0048266)2.30777475
156nonmotile primary cilium assembly (GO:0035058)2.28954325
157neural tube formation (GO:0001841)2.26238354
158glial cell proliferation (GO:0014009)2.26225987
159behavioral defense response (GO:0002209)2.25988744
160behavioral fear response (GO:0001662)2.25988744
161microtubule polymerization or depolymerization (GO:0031109)2.25491065
162glycerophospholipid catabolic process (GO:0046475)2.24767731
163calcium ion-dependent exocytosis (GO:0017156)2.24283670
164modulation by virus of host process (GO:0019054)2.24153849
165urinary tract smooth muscle contraction (GO:0014848)2.23994959
166inner ear receptor stereocilium organization (GO:0060122)2.22091763
167positive regulation of synaptic transmission, GABAergic (GO:0032230)2.21733959
168response to pheromone (GO:0019236)2.21732453
169extracellular regulation of signal transduction (GO:1900115)2.21027758
170extracellular negative regulation of signal transduction (GO:1900116)2.21027758
171membrane hyperpolarization (GO:0060081)2.20842654
172photoreceptor cell maintenance (GO:0045494)2.20660565
173regulation of excitatory postsynaptic membrane potential (GO:0060079)2.20211049
174regulation of postsynaptic membrane potential (GO:0060078)2.17925840

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.23595195
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.89602592
3GBX2_23144817_ChIP-Seq_PC3_Human4.18447636
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.02887064
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.76260891
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.72914910
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.49361034
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38225104
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38136898
10TAF15_26573619_Chip-Seq_HEK293_Human2.31197327
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25410592
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.14959387
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.11572254
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.10187286
15ZNF274_21170338_ChIP-Seq_K562_Hela2.09899861
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.09009045
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.08745410
18IGF1R_20145208_ChIP-Seq_DFB_Human2.06770896
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06325495
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.05444709
21* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04272607
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.97968012
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.96892430
24* P300_19829295_ChIP-Seq_ESCs_Human1.94905072
25E2F7_22180533_ChIP-Seq_HELA_Human1.91630123
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.90171248
27* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89098332
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88869431
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.87585105
30* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83493675
31RNF2_27304074_Chip-Seq_NSC_Mouse1.82428451
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.80164412
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76632413
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.76179745
35GATA1_22025678_ChIP-Seq_K562_Human1.75628128
36* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.71357069
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71315938
38REST_21632747_ChIP-Seq_MESCs_Mouse1.71101261
39VDR_22108803_ChIP-Seq_LS180_Human1.69735459
40CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69686323
41* NANOG_18555785_Chip-Seq_ESCs_Mouse1.68466595
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.66980691
43* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65717238
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.63877517
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.63877517
46* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.63133061
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62197699
48* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61757257
49FUS_26573619_Chip-Seq_HEK293_Human1.58919985
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58848295
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56903659
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.56681051
53* E2F1_18555785_Chip-Seq_ESCs_Mouse1.55534672
54* NFE2_27457419_Chip-Seq_LIVER_Mouse1.54538939
55* P53_22387025_ChIP-Seq_ESCs_Mouse1.54227064
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50592978
57* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.48904641
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48346066
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.48274399
60* EZH2_27294783_Chip-Seq_ESCs_Mouse1.47997441
61* CMYC_18555785_Chip-Seq_ESCs_Mouse1.45436382
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45269123
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44493406
64ER_23166858_ChIP-Seq_MCF-7_Human1.43843734
65* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43636468
66* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43367041
67* EZH2_27294783_Chip-Seq_NPCs_Mouse1.42918959
68* STAT3_18555785_Chip-Seq_ESCs_Mouse1.42324362
69* SMAD3_21741376_ChIP-Seq_EPCs_Human1.42082212
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41429235
71SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41356596
72* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.40584206
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40515836
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40515836
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.38963508
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38174890
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37789660
78AR_25329375_ChIP-Seq_VCAP_Human1.35552343
79* STAT3_23295773_ChIP-Seq_U87_Human1.35345703
80* SMAD3_21741376_ChIP-Seq_HESCs_Human1.34712638
81* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34611882
82* P300_18555785_Chip-Seq_ESCs_Mouse1.34568126
83REST_18959480_ChIP-ChIP_MESCs_Mouse1.34208164
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.33579836
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31547648
86* TAL1_26923725_Chip-Seq_HPCs_Mouse1.31001267
87* NMYC_18555785_Chip-Seq_ESCs_Mouse1.30669473
88IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30340453
89FOXM1_23109430_ChIP-Seq_U2OS_Human1.30169551
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29188431
91* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28883735
92* GATA1_26923725_Chip-Seq_HPCs_Mouse1.28838695
93* SOX2_18555785_Chip-Seq_ESCs_Mouse1.27893476
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.27824257
95* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27583910
96* TCF4_23295773_ChIP-Seq_U87_Human1.27086033
97DROSHA_22980978_ChIP-Seq_HELA_Human1.26688733
98* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.26133855
99E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25958302
100RUNX2_22187159_ChIP-Seq_PCA_Human1.24860429
101POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24352444
102CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.24037850
103* SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.23787211
104ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23610825
105* SMAD4_21741376_ChIP-Seq_HESCs_Human1.22462464
106* OCT4_18555785_Chip-Seq_ESCs_Mouse1.22285777
107KDM2B_26808549_Chip-Seq_REH_Human1.21240867
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21037716
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20887456
110CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20331038
111CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19136201
112WT1_19549856_ChIP-ChIP_CCG9911_Human1.19052357
113* PU1_27457419_Chip-Seq_LIVER_Mouse1.15265153
114AR_21572438_ChIP-Seq_LNCaP_Human1.14822041
115* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14664886
116SOX2_21211035_ChIP-Seq_LN229_Gbm1.14562785
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14298541
118* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14126080
119* KLF4_18555785_Chip-Seq_ESCs_Mouse1.13682881
120* ZFX_18555785_Chip-Seq_ESCs_Mouse1.13561072
121* CTCF_18555785_Chip-Seq_ESCs_Mouse1.13397830
122* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13394191
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.13386713
124EWS_26573619_Chip-Seq_HEK293_Human1.13118044
125STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12288480
126IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07656069
127CBP_20019798_ChIP-Seq_JUKART_Human1.07656069
128* SOX9_26525672_Chip-Seq_HEART_Mouse1.05803760
129TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03632097
130SMAD4_21741376_ChIP-Seq_EPCs_Human1.03410655
131* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01887079
132EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00971695
133TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98343601
134SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95032598

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.56898674
2MP0001188_hyperpigmentation3.18949458
3MP0005645_abnormal_hypothalamus_physiol3.16195385
4MP0006276_abnormal_autonomic_nervous3.15128429
5MP0003787_abnormal_imprinting3.06126342
6MP0002102_abnormal_ear_morphology2.90757097
7MP0006292_abnormal_olfactory_placode2.69505497
8MP0002735_abnormal_chemical_nociception2.68250968
9MP0001968_abnormal_touch/_nociception2.65961445
10MP0004859_abnormal_synaptic_plasticity2.62635214
11MP0002736_abnormal_nociception_after2.52833742
12MP0001486_abnormal_startle_reflex2.45141658
13MP0002822_catalepsy2.44119559
14MP0005646_abnormal_pituitary_gland2.37578406
15MP0001984_abnormal_olfaction2.35001565
16MP0003635_abnormal_synaptic_transmissio2.29167272
17MP0009745_abnormal_behavioral_response2.20571633
18MP0002063_abnormal_learning/memory/cond2.09423682
19MP0002572_abnormal_emotion/affect_behav2.02541709
20MP0005394_taste/olfaction_phenotype1.99954618
21MP0005499_abnormal_olfactory_system1.99954618
22MP0000569_abnormal_digit_pigmentation1.94629184
23MP0005083_abnormal_biliary_tract1.92493843
24MP0008789_abnormal_olfactory_epithelium1.89772429
25MP0005171_absent_coat_pigmentation1.87437365
26MP0000538_abnormal_urinary_bladder1.86021842
27MP0005423_abnormal_somatic_nervous1.81972903
28MP0000778_abnormal_nervous_system1.80280763
29MP0004270_analgesia1.80190835
30MP0002734_abnormal_mechanical_nocicepti1.76588851
31MP0009046_muscle_twitch1.75031346
32MP0002557_abnormal_social/conspecific_i1.74994206
33MP0005197_abnormal_uvea_morphology1.74297959
34MP0002272_abnormal_nervous_system1.69889801
35MP0002184_abnormal_innervation1.68338388
36MP0002638_abnormal_pupillary_reflex1.67958039
37MP0001501_abnormal_sleep_pattern1.67482731
38MP0005410_abnormal_fertilization1.66473693
39MP0002067_abnormal_sensory_capabilities1.66176198
40MP0001440_abnormal_grooming_behavior1.64961736
41MP0001529_abnormal_vocalization1.64913128
42MP0002064_seizures1.63918367
43MP0004742_abnormal_vestibular_system1.60674957
44MP0001270_distended_abdomen1.59800120
45MP0006072_abnormal_retinal_apoptosis1.55463209
46MP0005253_abnormal_eye_physiology1.54386126
47MP0001502_abnormal_circadian_rhythm1.53675353
48MP0002697_abnormal_eye_size1.51521315
49MP0009697_abnormal_copulation1.45737195
50MP0010386_abnormal_urinary_bladder1.44153555
51MP0003879_abnormal_hair_cell1.43077131
52MP0003136_yellow_coat_color1.42840352
53MP0001986_abnormal_taste_sensitivity1.41789142
54MP0000566_synostosis1.41331730
55MP0000026_abnormal_inner_ear1.40430942
56MP0002277_abnormal_respiratory_mucosa1.39509259
57MP0003283_abnormal_digestive_organ1.39432302
58MP0002876_abnormal_thyroid_physiology1.37707741
59MP0001299_abnormal_eye_distance/1.37528279
60MP0002733_abnormal_thermal_nociception1.37526807
61MP0003937_abnormal_limbs/digits/tail_de1.37499834
62MP0001485_abnormal_pinna_reflex1.37118324
63MP0002163_abnormal_gland_morphology1.36056910
64MP0001970_abnormal_pain_threshold1.35742553
65MP0000015_abnormal_ear_pigmentation1.34967492
66MP0008877_abnormal_DNA_methylation1.34316022
67MP0001963_abnormal_hearing_physiology1.32634006
68MP0000372_irregular_coat_pigmentation1.27095903
69MP0005391_vision/eye_phenotype1.26719842
70MP0001905_abnormal_dopamine_level1.26682109
71MP0008057_abnormal_DNA_replication1.19713422
72MP0003119_abnormal_digestive_system1.19549693
73MP0005551_abnormal_eye_electrophysiolog1.15325820
74MP0003878_abnormal_ear_physiology1.15277961
75MP0005377_hearing/vestibular/ear_phenot1.15277961
76MP0004134_abnormal_chest_morphology1.14106899
77MP0000427_abnormal_hair_cycle1.13977830
78MP0003121_genomic_imprinting1.13746680
79MP0000631_abnormal_neuroendocrine_gland1.12676282
80MP0005409_darkened_coat_color1.12406402
81MP0004924_abnormal_behavior1.11538991
82MP0005386_behavior/neurological_phenoty1.11538991
83MP0003861_abnormal_nervous_system1.07549594
84MP0005187_abnormal_penis_morphology1.07301940
85MP0005084_abnormal_gallbladder_morpholo1.06742986
86MP0005195_abnormal_posterior_eye1.05722170
87MP0008260_abnormal_autophagy1.03964687
88MP0005379_endocrine/exocrine_gland_phen0.98067872
89MP0002127_abnormal_cardiovascular_syste0.98055255
90MP0002882_abnormal_neuron_morphology0.97378555
91MP0002752_abnormal_somatic_nervous0.96473313
92MP0003632_abnormal_nervous_system0.96272678
93MP0002909_abnormal_adrenal_gland0.94649242
94MP0003698_abnormal_male_reproductive0.94184182
95MP0002938_white_spotting0.93722689
96MP0003935_abnormal_craniofacial_develop0.92121248
97MP0008058_abnormal_DNA_repair0.91358380
98MP0003567_abnormal_fetal_cardiomyocyte0.90997952
99MP0002092_abnormal_eye_morphology0.89214520
100MP0008995_early_reproductive_senescence0.88905478
101MP0002249_abnormal_larynx_morphology0.88443597
102MP0000681_abnormal_thyroid_gland0.88432147
103MP0004215_abnormal_myocardial_fiber0.87829869
104MP0003122_maternal_imprinting0.87754934
105MP0001286_abnormal_eye_development0.81541263
106MP0005174_abnormal_tail_pigmentation0.80936125
107MP0004782_abnormal_surfactant_physiolog0.80070374
108MP0004858_abnormal_nervous_system0.78858219
109MP0003938_abnormal_ear_development0.78523640
110MP0003183_abnormal_peptide_metabolism0.76511187
111MP0002751_abnormal_autonomic_nervous0.76452803
112MP0004142_abnormal_muscle_tone0.75403482
113MP0003385_abnormal_body_wall0.75243276
114MP0004811_abnormal_neuron_physiology0.74722464
115MP0002081_perinatal_lethality0.74274689
116MP0005670_abnormal_white_adipose0.74247892
117MP0001293_anophthalmia0.73849041
118MP0003137_abnormal_impulse_conducting0.71530418
119MP0004133_heterotaxia0.71453098
120MP0002066_abnormal_motor_capabilities/c0.71087253
121MP0002233_abnormal_nose_morphology0.70349002
122MP0000049_abnormal_middle_ear0.69764250
123MP0004145_abnormal_muscle_electrophysio0.67826997
124MP0001177_atelectasis0.67676483
125MP0002152_abnormal_brain_morphology0.66992669
126MP0002132_abnormal_respiratory_system0.66761603
127MP0001346_abnormal_lacrimal_gland0.66473441
128MP0010094_abnormal_chromosome_stability0.66024282
129MP0009250_abnormal_appendicular_skeleto0.65240550
130MP0003755_abnormal_palate_morphology0.64159998
131MP0003890_abnormal_embryonic-extraembry0.63359581
132MP0002160_abnormal_reproductive_system0.62980062
133MP0000955_abnormal_spinal_cord0.62035030
134MP0002234_abnormal_pharynx_morphology0.61475052
135MP0001929_abnormal_gametogenesis0.58365164
136MP0002069_abnormal_eating/drinking_beha0.58363582
137MP0002210_abnormal_sex_determination0.55941402
138MP0005310_abnormal_salivary_gland0.55093426

Predicted human phenotypes

RankGene SetZ-score
1Asymmetry of the thorax (HP:0001555)5.44985523
2Febrile seizures (HP:0002373)4.75442356
3Focal motor seizures (HP:0011153)4.58838811
4Absent/shortened dynein arms (HP:0200106)4.34508825
5Dynein arm defect of respiratory motile cilia (HP:0012255)4.34508825
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.20279507
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.87533694
8Pancreatic fibrosis (HP:0100732)3.55544020
9Abnormal ciliary motility (HP:0012262)3.55080672
10Abnormal respiratory motile cilium physiology (HP:0012261)3.41254400
11Chromsome breakage (HP:0040012)3.35931484
12True hermaphroditism (HP:0010459)3.31649948
13Type 2 muscle fiber atrophy (HP:0003554)3.27212581
14Breast hypoplasia (HP:0003187)3.25868749
15Intestinal atresia (HP:0011100)3.25736304
16Medial flaring of the eyebrow (HP:0010747)3.24851680
17Tubulointerstitial fibrosis (HP:0005576)3.24374091
18Abnormal respiratory motile cilium morphology (HP:0005938)3.22921040
19Abnormal respiratory epithelium morphology (HP:0012253)3.22921040
20Hypoplastic nipples (HP:0002557)3.22788304
21Tubulointerstitial abnormality (HP:0001969)3.11870791
22Cortical dysplasia (HP:0002539)3.11746366
23Chronic hepatic failure (HP:0100626)3.09313425
24Nephronophthisis (HP:0000090)3.08793008
25Hypothermia (HP:0002045)3.02349586
26Epileptic encephalopathy (HP:0200134)3.00166639
27Gait imbalance (HP:0002141)2.99594779
28Nephrogenic diabetes insipidus (HP:0009806)2.95198819
29Congenital primary aphakia (HP:0007707)2.86370235
30Protruding tongue (HP:0010808)2.84759502
31Tubulointerstitial nephritis (HP:0001970)2.83554289
32Submucous cleft hard palate (HP:0000176)2.82220965
33Anterior segment dysgenesis (HP:0007700)2.81540637
34Molar tooth sign on MRI (HP:0002419)2.77771050
35Abnormality of midbrain morphology (HP:0002418)2.77771050
36Focal seizures (HP:0007359)2.76663665
37Abnormality of the renal medulla (HP:0100957)2.75779635
38Pancreatic cysts (HP:0001737)2.66721978
39Palpebral edema (HP:0100540)2.65755223
40Atonic seizures (HP:0010819)2.64282980
41Increased corneal curvature (HP:0100692)2.62537058
42Keratoconus (HP:0000563)2.62537058
43Supernumerary spleens (HP:0009799)2.58121068
44Prostate neoplasm (HP:0100787)2.56865131
45Oligodactyly (hands) (HP:0001180)2.56138171
46Postaxial foot polydactyly (HP:0001830)2.55584296
47Muscle fiber atrophy (HP:0100295)2.54834127
48Abnormal hair whorl (HP:0010721)2.54606881
49Short 4th metacarpal (HP:0010044)2.53560519
50Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.53560519
51Hepatoblastoma (HP:0002884)2.52026280
52Abnormality of the intervertebral disk (HP:0005108)2.51177820
53Generalized hypotonia (HP:0001290)2.47870678
54Abnormal pancreas size (HP:0012094)2.40335887
55Poor coordination (HP:0002370)2.37885775
56Esophageal atresia (HP:0002032)2.35044285
57Septo-optic dysplasia (HP:0100842)2.34832795
58Congenital hepatic fibrosis (HP:0002612)2.32385728
59Fetal akinesia sequence (HP:0001989)2.29809904
60Hypoventilation (HP:0002791)2.29685051
61Aqueductal stenosis (HP:0002410)2.25794485
62Congenital sensorineural hearing impairment (HP:0008527)2.23837546
63Retinal dysplasia (HP:0007973)2.22336927
64Genital tract atresia (HP:0001827)2.22227628
65Fair hair (HP:0002286)2.22187183
66Narrow forehead (HP:0000341)2.20465271
67Decreased central vision (HP:0007663)2.20337137
68Fatigable weakness (HP:0003473)2.19996693
69Abnormality of the neuromuscular junction (HP:0003398)2.19996693
70Preaxial hand polydactyly (HP:0001177)2.19247865
71Hyperventilation (HP:0002883)2.17024909
72Vaginal atresia (HP:0000148)2.16736659
73Optic nerve hypoplasia (HP:0000609)2.16519625
74Aplasia/Hypoplasia of the lens (HP:0008063)2.16224656
75Rhinitis (HP:0012384)2.15375828
76Progressive cerebellar ataxia (HP:0002073)2.14506002
77Postaxial hand polydactyly (HP:0001162)2.13648414
78Aplasia/Hypoplasia of the nipples (HP:0006709)2.13027863
79Generalized hypopigmentation of hair (HP:0011358)2.10826403
80Myokymia (HP:0002411)2.09540828
81Hypotrichosis (HP:0001006)2.07152926
82Occipital encephalocele (HP:0002085)2.06698960
83Sandal gap (HP:0001852)2.05647795
84Male pseudohermaphroditism (HP:0000037)2.04924793
85Aplasia/Hypoplasia of the tongue (HP:0010295)2.03574529
86Abnormality of hair growth rate (HP:0011363)2.02355112
87Slow-growing hair (HP:0002217)2.02355112
88Abdominal situs inversus (HP:0003363)2.02283582
89Abnormality of abdominal situs (HP:0011620)2.02283582
90Bony spicule pigmentary retinopathy (HP:0007737)2.00601872
91Abnormality of the phalanges of the 2nd finger (HP:0009541)2.00412454
92Poor suck (HP:0002033)1.99000361
93Abnormality of the aortic arch (HP:0012303)1.96309016
94Optic neuritis (HP:0100653)1.94356792
95Retrobulbar optic neuritis (HP:0100654)1.94356792
96Absent eyebrow (HP:0002223)1.93529138
97Abnormality of chromosome stability (HP:0003220)1.92990707
98Exotropia (HP:0000577)1.91741782
99Aplasia/Hypoplasia of the fovea (HP:0008060)1.91580295
100Hypoplasia of the fovea (HP:0007750)1.91580295
101Meckel diverticulum (HP:0002245)1.89715397
102Generalized tonic-clonic seizures (HP:0002069)1.89417698
103Median cleft lip (HP:0000161)1.88821427
104Absent speech (HP:0001344)1.88390402
105Excessive salivation (HP:0003781)1.88285005
106Drooling (HP:0002307)1.88285005
107Volvulus (HP:0002580)1.86286116
108Abnormality of the ileum (HP:0001549)1.85063745
109Patellar aplasia (HP:0006443)1.83787854
110Facial asymmetry (HP:0000324)1.83368295
111Hip dysplasia (HP:0001385)1.82926796
112Biliary tract neoplasm (HP:0100574)1.82565380
113Cupped ear (HP:0000378)1.81796536
114Astigmatism (HP:0000483)1.80718774
115Abnormality of the renal collecting system (HP:0004742)1.80623657
116Neuroblastoma (HP:0003006)1.79942607
117Primitive neuroectodermal tumor (HP:0030065)1.79942607
118Neuroblastic tumors (HP:0004376)1.79942607
119Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.79942607
120Aplasia/Hypoplasia of the uvula (HP:0010293)1.78222918
121Short tibia (HP:0005736)1.77779232
122Inability to walk (HP:0002540)1.76969985
123Labial hypoplasia (HP:0000066)1.76809835
124Absence seizures (HP:0002121)1.76296136
125Neonatal hypoglycemia (HP:0001998)1.75949829
126Blue irides (HP:0000635)1.75506193
127Bifid tongue (HP:0010297)1.73870907
128Chin dimple (HP:0010751)1.73699743
129Large earlobe (HP:0009748)1.73353522
130Aganglionic megacolon (HP:0002251)1.71650024
131Broad-based gait (HP:0002136)1.71644258
132Duplicated collecting system (HP:0000081)1.71607780
133Abnormality of the 4th metacarpal (HP:0010012)1.71186840
134Cystic liver disease (HP:0006706)1.70075506
135Aplasia/Hypoplasia of the tibia (HP:0005772)1.69871396
136Wide anterior fontanel (HP:0000260)1.69585278
137Abnormal number of incisors (HP:0011064)1.69315344
138Abnormality of incisor morphology (HP:0011063)1.68757349
139Abnormal biliary tract physiology (HP:0012439)1.68218850
140Bile duct proliferation (HP:0001408)1.68218850
141Clubbing of toes (HP:0100760)1.67846205
142Dyschromatopsia (HP:0007641)1.67726649
143Esotropia (HP:0000565)1.67404595
144Abnormality of salivation (HP:0100755)1.67194152
145Highly arched eyebrow (HP:0002553)1.67113453
146Dialeptic seizures (HP:0011146)1.66847113
147Abnormality of the fovea (HP:0000493)1.65415984
148Oligodactyly (HP:0012165)1.65398180
149Aplasia/Hypoplasia of the brainstem (HP:0007362)1.64982698
150Hypoplasia of the brainstem (HP:0002365)1.64982698
151Midline defect of the nose (HP:0004122)1.64053777
152Nephroblastoma (Wilms tumor) (HP:0002667)1.63763152
153Cutaneous finger syndactyly (HP:0010554)1.63706027
154Chorioretinal coloboma (HP:0000567)1.63606685
155Anophthalmia (HP:0000528)1.63393330
156White forelock (HP:0002211)1.63298217
157Aplasia/Hypoplasia of the patella (HP:0006498)1.63192607
158Absent septum pellucidum (HP:0001331)1.62489617
159Increased IgM level (HP:0003496)1.61555135
160Embryonal renal neoplasm (HP:0011794)1.61029361
161Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.60783985
162Anencephaly (HP:0002323)1.60735555
163Congenital malformation of the right heart (HP:0011723)1.60426955
164Double outlet right ventricle (HP:0001719)1.60426955
165Abnormality of the labia minora (HP:0012880)1.60252607
166Partial agenesis of the corpus callosum (HP:0001338)1.60245706
167Secondary amenorrhea (HP:0000869)1.59949890
168Alveolar cell carcinoma (HP:0006519)1.59480854
169Renovascular hypertension (HP:0100817)1.59338492
170Overgrowth (HP:0001548)1.59286358
171Abnormality of the septum pellucidum (HP:0007375)1.58217973
172Pachygyria (HP:0001302)1.58010610
173Abnormality of macular pigmentation (HP:0008002)1.57884524
174Intellectual disability, moderate (HP:0002342)1.56343078
175Gaze-evoked nystagmus (HP:0000640)1.55408739
176Mediastinal lymphadenopathy (HP:0100721)1.54774743

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.15524808
2MAP2K73.22902503
3TNIK3.21891379
4TLK12.95890130
5NTRK32.93530526
6PRPF4B2.87121350
7NTRK12.83504297
8MAP3K122.79413211
9SIK32.71844668
10MAPK132.33189113
11BMPR22.29568230
12BMPR1B2.20070370
13ADRBK22.15866194
14ERBB32.15487352
15MAP3K42.11686423
16TXK2.06229418
17MARK12.05935903
18FRK1.96383226
19MATK1.87845383
20PLK41.84798949
21NTRK21.75193569
22MAP3K101.71836786
23NME11.70586357
24AKT31.69370258
25MUSK1.68804052
26SIK21.67684497
27INSRR1.65258525
28SGK21.63572166
29STK161.56680294
30RIPK41.53707539
31MAP3K141.53595576
32PLK21.51742604
33CDC71.51649557
34EPHA41.48093015
35NEK21.45768992
36WNK31.42716160
37CDK81.32854528
38YES11.31864996
39MKNK21.24457375
40ERBB21.23739374
41ZAK1.18111817
42EIF2AK21.16723012
43MINK11.12813346
44TRIM281.12522624
45IRAK41.10052331
46CDK31.09982188
47MAP3K131.08678247
48RIPK11.08363593
49MAP3K61.07437940
50SGK4941.06921545
51SGK2231.06921545
52MAP4K21.05299226
53STK38L1.05087306
54BRD41.00800223
55GRK71.00139169
56CSNK1G10.99522128
57CAMKK10.94144572
58ATR0.93646678
59MAP2K40.93292477
60ACVR1B0.91917235
61NUAK10.86037234
62NEK60.85634522
63LATS10.85079657
64PAK30.83012624
65CAMK2A0.82224285
66BCR0.81791201
67BRAF0.80654859
68TIE10.79054072
69PRKCE0.78880809
70CSNK1G20.78589233
71SGK30.77054384
72PRKCG0.76586341
73TTK0.75317415
74CSNK1G30.75021092
75PBK0.73308060
76CHEK20.73073111
77PINK10.70523998
78TNK20.69058861
79DAPK10.68433565
80CAMK1G0.68086366
81PRKCZ0.67000960
82TGFBR10.66953713
83ATM0.66837945
84KSR10.65424659
85PNCK0.65328706
86IKBKE0.65287392
87PLK10.64507211
88EPHB20.64436377
89SRPK10.64308646
90SGK10.64115951
91ADRBK10.64036601
92AURKA0.61982675
93TYRO30.61424729
94CSNK1A1L0.59152685
95DAPK20.59130573
96FES0.59079395
97TSSK60.58867106
98DYRK1A0.57681975
99DYRK20.56762426
100PRKAA10.55852637
101PRKCH0.54523945
102CAMK1D0.54233408
103CAMKK20.53376208
104GRK10.52946650
105FGFR20.51884756
106CDK50.51647853
107IRAK30.51430417
108PTK2B0.51009585
109DYRK1B0.50759852
110MKNK10.50515027
111RPS6KA50.50124271
112IRAK10.50016406
113STK240.48646136
114PRKACB0.47272572
115MARK20.46897354
116CSNK1D0.45821217
117CAMK2B0.43797044
118VRK10.43206659
119DDR20.42983290
120UHMK10.42597670
121CDK10.42055443
122CDK20.41840535
123GSK3B0.41799577
124CAMK40.41698495
125CDK120.41547759
126PRKG10.39437020
127SYK0.38762520
128GRK50.38387881
129ICK0.37890571
130ERBB40.37702973
131PDK20.37251838
132CSNK1E0.36805092
133AURKB0.35307773
134PKN10.35250861
135TEC0.35162589
136OXSR10.34644557
137PRKDC0.34079332
138CCNB10.32870736
139IRAK20.30259295
140LYN0.27983073
141PRKCQ0.27363069
142PRKACA0.26791045
143CAMK2D0.26514452
144BLK0.24253557
145TRPM70.23400850
146ARAF0.23069183
147RPS6KB10.22433838
148TAOK30.22166213
149PRKCB0.21502318
150MAPK80.20286143
151CDK190.19199871
152CAMK10.18762882

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.00980608
2Olfactory transduction_Homo sapiens_hsa047402.78460952
3Morphine addiction_Homo sapiens_hsa050322.45330465
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.38593622
5Taste transduction_Homo sapiens_hsa047422.31824826
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.30359091
7Systemic lupus erythematosus_Homo sapiens_hsa053222.27116379
8Circadian entrainment_Homo sapiens_hsa047132.05555624
9Glutamatergic synapse_Homo sapiens_hsa047242.04202373
10Serotonergic synapse_Homo sapiens_hsa047262.02337013
11Synaptic vesicle cycle_Homo sapiens_hsa047211.94565481
12GABAergic synapse_Homo sapiens_hsa047271.85612180
13Phototransduction_Homo sapiens_hsa047441.77039986
14Cell cycle_Homo sapiens_hsa041101.63024278
15Collecting duct acid secretion_Homo sapiens_hsa049661.50698684
16Amphetamine addiction_Homo sapiens_hsa050311.47467200
17Calcium signaling pathway_Homo sapiens_hsa040201.45916819
18Cholinergic synapse_Homo sapiens_hsa047251.44328788
19Dopaminergic synapse_Homo sapiens_hsa047281.39731048
20Long-term potentiation_Homo sapiens_hsa047201.33116628
21Rheumatoid arthritis_Homo sapiens_hsa053231.32692092
22Long-term depression_Homo sapiens_hsa047301.31030467
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.29244181
24Autoimmune thyroid disease_Homo sapiens_hsa053201.27552991
25Fanconi anemia pathway_Homo sapiens_hsa034601.25462773
26Allograft rejection_Homo sapiens_hsa053301.23817644
27Salivary secretion_Homo sapiens_hsa049701.23632719
28Non-homologous end-joining_Homo sapiens_hsa034501.23195408
29Butanoate metabolism_Homo sapiens_hsa006501.21816765
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.20857245
31Graft-versus-host disease_Homo sapiens_hsa053321.20331911
32Hedgehog signaling pathway_Homo sapiens_hsa043401.17465221
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17369667
34Lysine degradation_Homo sapiens_hsa003101.15768142
35Renin secretion_Homo sapiens_hsa049241.15296557
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14976968
37Insulin secretion_Homo sapiens_hsa049111.13703560
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13598522
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.13340732
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12180907
41African trypanosomiasis_Homo sapiens_hsa051431.12022505
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10939729
43Type I diabetes mellitus_Homo sapiens_hsa049401.10653174
44Axon guidance_Homo sapiens_hsa043601.08848444
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08003354
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06806595
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06723738
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03672616
49Oocyte meiosis_Homo sapiens_hsa041141.02720613
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02175677
51Regulation of autophagy_Homo sapiens_hsa041401.01324970
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00411723
53Cocaine addiction_Homo sapiens_hsa050301.00228078
54TGF-beta signaling pathway_Homo sapiens_hsa043500.96669167
55mRNA surveillance pathway_Homo sapiens_hsa030150.95558038
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95314367
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94416978
58cAMP signaling pathway_Homo sapiens_hsa040240.92700659
59Basal cell carcinoma_Homo sapiens_hsa052170.90432173
60ABC transporters_Homo sapiens_hsa020100.89422833
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89330642
62Mismatch repair_Homo sapiens_hsa034300.88870001
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88733971
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86812481
65Fatty acid metabolism_Homo sapiens_hsa012120.86661090
66Oxytocin signaling pathway_Homo sapiens_hsa049210.85744684
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84139707
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83880897
69Phagosome_Homo sapiens_hsa041450.81384963
70ErbB signaling pathway_Homo sapiens_hsa040120.81347332
71Ovarian steroidogenesis_Homo sapiens_hsa049130.81248048
72RNA transport_Homo sapiens_hsa030130.80946906
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80921925
74Asthma_Homo sapiens_hsa053100.80407509
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80067259
76Dilated cardiomyopathy_Homo sapiens_hsa054140.79147979
77Chemokine signaling pathway_Homo sapiens_hsa040620.78762060
78Cardiac muscle contraction_Homo sapiens_hsa042600.78581468
79Hippo signaling pathway_Homo sapiens_hsa043900.77417163
80Fatty acid biosynthesis_Homo sapiens_hsa000610.76465521
81Basal transcription factors_Homo sapiens_hsa030220.75771103
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.74988031
83MicroRNAs in cancer_Homo sapiens_hsa052060.73936270
84Measles_Homo sapiens_hsa051620.71789272
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71282184
86Inositol phosphate metabolism_Homo sapiens_hsa005620.69679463
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68172958
88Ras signaling pathway_Homo sapiens_hsa040140.67767178
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.67710684
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67581922
91MAPK signaling pathway_Homo sapiens_hsa040100.67460350
92Sphingolipid metabolism_Homo sapiens_hsa006000.67391725
93GnRH signaling pathway_Homo sapiens_hsa049120.66616808
94Circadian rhythm_Homo sapiens_hsa047100.66132038
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66038023
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65731459
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65137281
98Gastric acid secretion_Homo sapiens_hsa049710.64078209
99Tight junction_Homo sapiens_hsa045300.63986780
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63918551
101Wnt signaling pathway_Homo sapiens_hsa043100.63531439
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62292775
103TNF signaling pathway_Homo sapiens_hsa046680.61445817
104ECM-receptor interaction_Homo sapiens_hsa045120.61185502
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60670884
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60332745
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59797918
108Ether lipid metabolism_Homo sapiens_hsa005650.59615860
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59471668
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57655775
111Type II diabetes mellitus_Homo sapiens_hsa049300.56384045
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55818651
113Gap junction_Homo sapiens_hsa045400.55711659
114Choline metabolism in cancer_Homo sapiens_hsa052310.55288263
115Vibrio cholerae infection_Homo sapiens_hsa051100.54855507
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.54525058
117Primary immunodeficiency_Homo sapiens_hsa053400.54390634
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54001414
119Melanogenesis_Homo sapiens_hsa049160.53751363
120Tuberculosis_Homo sapiens_hsa051520.53251366
121Colorectal cancer_Homo sapiens_hsa052100.53214684
122Influenza A_Homo sapiens_hsa051640.52538751
123Glycerolipid metabolism_Homo sapiens_hsa005610.51663570
124Prolactin signaling pathway_Homo sapiens_hsa049170.51226357
125Hematopoietic cell lineage_Homo sapiens_hsa046400.49543401
126Estrogen signaling pathway_Homo sapiens_hsa049150.49282948
127Rap1 signaling pathway_Homo sapiens_hsa040150.48948535
128Selenocompound metabolism_Homo sapiens_hsa004500.48299374
129Melanoma_Homo sapiens_hsa052180.47332811
130Glioma_Homo sapiens_hsa052140.46511016
131p53 signaling pathway_Homo sapiens_hsa041150.46485274
132Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45279141
133Non-small cell lung cancer_Homo sapiens_hsa052230.45072756
134Alcoholism_Homo sapiens_hsa050340.44505739
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.43534278
136FoxO signaling pathway_Homo sapiens_hsa040680.42871021
137Notch signaling pathway_Homo sapiens_hsa043300.42622513
138Homologous recombination_Homo sapiens_hsa034400.42280289
139Base excision repair_Homo sapiens_hsa034100.41969747
140AMPK signaling pathway_Homo sapiens_hsa041520.41823829
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41653397
142Salmonella infection_Homo sapiens_hsa051320.39895450
143Leishmaniasis_Homo sapiens_hsa051400.39860790
144Arachidonic acid metabolism_Homo sapiens_hsa005900.38062613
145Endometrial cancer_Homo sapiens_hsa052130.37883664
146Osteoclast differentiation_Homo sapiens_hsa043800.37785849
147Jak-STAT signaling pathway_Homo sapiens_hsa046300.37770518
148Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37090195

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