THTPA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme which catalyzes the biosynthesis of thiamine disphophate (vitamin B1) by hydrolysis of thiamine triphosphate. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.19017585
2L-phenylalanine catabolic process (GO:0006559)5.19017585
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.71351591
4L-phenylalanine metabolic process (GO:0006558)4.71351591
5mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.56901565
6mitochondrial respiratory chain complex I assembly (GO:0032981)4.56901565
7NADH dehydrogenase complex assembly (GO:0010257)4.56901565
8protein complex biogenesis (GO:0070271)4.51422564
9pyrimidine nucleobase catabolic process (GO:0006208)4.48498833
10chaperone-mediated protein transport (GO:0072321)4.41372184
11sodium-independent organic anion transport (GO:0043252)4.34449096
12response to misfolded protein (GO:0051788)4.08186962
13mitochondrial respiratory chain complex assembly (GO:0033108)4.05641600
14regulation of autophagic vacuole assembly (GO:2000785)4.03903509
15positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.00552662
16positive regulation of fatty acid biosynthetic process (GO:0045723)3.89841450
17aromatic amino acid family catabolic process (GO:0009074)3.89759823
18ubiquinone biosynthetic process (GO:0006744)3.85300108
19L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.77824232
20positive regulation of mitochondrial fission (GO:0090141)3.73447450
21pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.71562293
22nucleobase catabolic process (GO:0046113)3.69637957
23alpha-linolenic acid metabolic process (GO:0036109)3.61892871
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.61283111
25ubiquinone metabolic process (GO:0006743)3.60745509
26mannosylation (GO:0097502)3.60410035
27peptidyl-histidine modification (GO:0018202)3.58073303
28bile acid biosynthetic process (GO:0006699)3.57684131
29establishment of protein localization to mitochondrial membrane (GO:0090151)3.57077757
30activated T cell proliferation (GO:0050798)3.55271863
31valine metabolic process (GO:0006573)3.47732329
32energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.47070462
33ATP hydrolysis coupled proton transport (GO:0015991)3.47070462
34glyoxylate metabolic process (GO:0046487)3.44616043
35gamma-aminobutyric acid transport (GO:0015812)3.44370885
36response to pheromone (GO:0019236)3.39910562
37cellular ketone body metabolic process (GO:0046950)3.38263694
38energy coupled proton transport, down electrochemical gradient (GO:0015985)3.37978923
39ATP synthesis coupled proton transport (GO:0015986)3.37978923
40base-excision repair, AP site formation (GO:0006285)3.37464504
41regulation of vacuole organization (GO:0044088)3.37067465
42mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.36777796
43preassembly of GPI anchor in ER membrane (GO:0016254)3.32039279
44amino acid salvage (GO:0043102)3.31059866
45L-methionine salvage (GO:0071267)3.31059866
46L-methionine biosynthetic process (GO:0071265)3.31059866
47coenzyme catabolic process (GO:0009109)3.28527210
48synaptic vesicle maturation (GO:0016188)3.17593477
49respiratory electron transport chain (GO:0022904)3.17444113
50electron transport chain (GO:0022900)3.17410488
51deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.16673897
52mitochondrion degradation (GO:0000422)3.13726184
53regulation of short-term neuronal synaptic plasticity (GO:0048172)3.11870990
54glutamate metabolic process (GO:0006536)3.11547023
55pyrimidine nucleotide catabolic process (GO:0006244)3.10754224
56positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.10659566
57fatty acid elongation (GO:0030497)3.10644822
58quinone biosynthetic process (GO:1901663)3.07990793
59behavioral response to nicotine (GO:0035095)3.05599389
60peroxisome fission (GO:0016559)3.02606437
61bile acid metabolic process (GO:0008206)3.01216041
62negative regulation of telomere maintenance (GO:0032205)3.00106792
63regulation of mitochondrial translation (GO:0070129)2.99796191
64negative regulation of fibrinolysis (GO:0051918)2.98159191
65kynurenine metabolic process (GO:0070189)2.97155423
66glutamate secretion (GO:0014047)2.96307823
67mitochondrion morphogenesis (GO:0070584)2.95856093
68intracellular protein transmembrane import (GO:0044743)2.95281919
69protein targeting to mitochondrion (GO:0006626)2.93263482
70vocalization behavior (GO:0071625)2.93154735
71ketone body metabolic process (GO:1902224)2.91486162
72ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.89979015
73regulation of cilium movement (GO:0003352)2.89884260
74protein polyglutamylation (GO:0018095)2.89317928
75water-soluble vitamin biosynthetic process (GO:0042364)2.88705593
76cytochrome complex assembly (GO:0017004)2.87702234
77respiratory chain complex IV assembly (GO:0008535)2.87639608
78sulfur amino acid catabolic process (GO:0000098)2.84097430
79dicarboxylic acid biosynthetic process (GO:0043650)2.83967683
80tyrosine metabolic process (GO:0006570)2.83961954
81triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.83839520
82alpha-amino acid catabolic process (GO:1901606)2.82776962
83establishment of protein localization to mitochondrion (GO:0072655)2.80338103
84dicarboxylic acid catabolic process (GO:0043649)2.80256452
85DNA deamination (GO:0045006)2.79960610
86indolalkylamine catabolic process (GO:0046218)2.77701750
87tryptophan catabolic process (GO:0006569)2.77701750
88indole-containing compound catabolic process (GO:0042436)2.77701750
89regulation of synaptic vesicle exocytosis (GO:2000300)2.75814180
90lysine catabolic process (GO:0006554)2.75521991
91lysine metabolic process (GO:0006553)2.75521991
92cerebellar granule cell differentiation (GO:0021707)2.75303848
93urea cycle (GO:0000050)2.74923006
94urea metabolic process (GO:0019627)2.74923006
95platelet dense granule organization (GO:0060155)2.74089706
96aspartate family amino acid catabolic process (GO:0009068)2.73962597
97locomotory exploration behavior (GO:0035641)2.70360011
98hydrogen ion transmembrane transport (GO:1902600)2.70170268
99protein localization to mitochondrion (GO:0070585)2.69970750
100inner mitochondrial membrane organization (GO:0007007)2.69263780
101regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.68941090
102neurotransmitter secretion (GO:0007269)2.68779761
103cofactor catabolic process (GO:0051187)2.68108976
104negative regulation of reactive oxygen species metabolic process (GO:2000378)2.67966191
105cellular amino acid catabolic process (GO:0009063)2.67690524
106synaptic vesicle docking involved in exocytosis (GO:0016081)2.67463714
107dendrite morphogenesis (GO:0048813)2.67216056
108tryptophan metabolic process (GO:0006568)2.66904905
109regulation of fibrinolysis (GO:0051917)2.66726343
110positive regulation of fatty acid metabolic process (GO:0045923)2.65100005
111regulation of synapse structural plasticity (GO:0051823)2.63796230
112complement activation, alternative pathway (GO:0006957)2.63356904
113negative regulation of lipase activity (GO:0060192)2.62626073
114neuron cell-cell adhesion (GO:0007158)2.61790141
115membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.61762145
116regulation of cholesterol homeostasis (GO:2000188)2.61653114
117positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.61237806
118aromatic amino acid family metabolic process (GO:0009072)2.61188187
119synaptic vesicle exocytosis (GO:0016079)2.61116556
120ADP metabolic process (GO:0046031)2.60954845
121peptidyl-arginine omega-N-methylation (GO:0035247)2.60823293
122cysteine metabolic process (GO:0006534)2.59418464
123succinate metabolic process (GO:0006105)2.58923149
124GTP biosynthetic process (GO:0006183)2.57837048
125positive regulation of protein homooligomerization (GO:0032464)2.57001444
126high-density lipoprotein particle remodeling (GO:0034375)2.56773031
127positive regulation of icosanoid secretion (GO:0032305)2.56520958
128C-terminal protein lipidation (GO:0006501)2.56517152
129very long-chain fatty acid metabolic process (GO:0000038)2.56082344
130regulation of protein activation cascade (GO:2000257)2.53811179
131nitrogen cycle metabolic process (GO:0071941)2.53766965
132positive regulation of catecholamine secretion (GO:0033605)2.53207593
133negative regulation of synaptic transmission, GABAergic (GO:0032229)2.52668926
134short-chain fatty acid metabolic process (GO:0046459)2.52268897
135neurotransmitter-gated ion channel clustering (GO:0072578)2.52146968
136tricarboxylic acid metabolic process (GO:0072350)2.52114614
137fatty-acyl-CoA biosynthetic process (GO:0046949)2.52004292
138synaptic transmission, glutamatergic (GO:0035249)2.51963200
139proton transport (GO:0015992)2.51888887
140central nervous system myelination (GO:0022010)2.51768454
141axon ensheathment in central nervous system (GO:0032291)2.51768454
142intracellular protein transmembrane transport (GO:0065002)2.51352127
143RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.50763178
144tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.50763178
145layer formation in cerebral cortex (GO:0021819)2.49761095
146protein insertion into membrane (GO:0051205)2.49521279
147hydrogen transport (GO:0006818)2.49466019
148fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.48588485
149regulation of glutamate receptor signaling pathway (GO:1900449)2.48042271
150regulation of mitochondrial fission (GO:0090140)2.47336915
151cellular response to glucagon stimulus (GO:0071377)2.47311471
152regulation of microtubule-based movement (GO:0060632)2.46128886
153cellular potassium ion homeostasis (GO:0030007)2.46028319
154regulation of synaptic vesicle transport (GO:1902803)2.45240115
155long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.44648878
156regulation of oxidative phosphorylation (GO:0002082)2.44611461
157triglyceride homeostasis (GO:0070328)2.44215232
158acylglycerol homeostasis (GO:0055090)2.44215232
159protein import into peroxisome matrix (GO:0016558)2.43684647
1602-oxoglutarate metabolic process (GO:0006103)2.43473408
161deoxyribonucleotide catabolic process (GO:0009264)2.42531794
162nucleoside diphosphate phosphorylation (GO:0006165)2.42514291
163neuronal ion channel clustering (GO:0045161)2.42462429
164branched-chain amino acid metabolic process (GO:0009081)2.42023943
165acetyl-CoA metabolic process (GO:0006084)2.41308590
166sperm motility (GO:0030317)2.41168653
167glial cell proliferation (GO:0014009)2.40519149
168epithelial cilium movement (GO:0003351)2.40380241
169negative regulation of necroptotic process (GO:0060546)2.38914386
170viral protein processing (GO:0019082)2.38523278
171tRNA processing (GO:0008033)2.37863223
172acyl-CoA biosynthetic process (GO:0071616)2.37380259
173thioester biosynthetic process (GO:0035384)2.37380259
174branched-chain amino acid catabolic process (GO:0009083)2.36852521
175transferrin transport (GO:0033572)2.36653624
176regulation of complement activation (GO:0030449)2.35904299
177nonmotile primary cilium assembly (GO:0035058)2.35681036
178central nervous system projection neuron axonogenesis (GO:0021952)2.34673383
179xenobiotic catabolic process (GO:0042178)2.34299428
180ionotropic glutamate receptor signaling pathway (GO:0035235)2.34105832
181negative regulation of microtubule polymerization (GO:0031115)2.33964048
182axoneme assembly (GO:0035082)2.31814329
183ethanol oxidation (GO:0006069)2.31711037
184positive regulation of TOR signaling (GO:0032008)2.31176639
185organic acid catabolic process (GO:0016054)2.30872565
186negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.28945524
187C-terminal protein amino acid modification (GO:0018410)2.28816374
188trivalent inorganic cation transport (GO:0072512)2.28758031
189ferric iron transport (GO:0015682)2.28758031
190dendritic spine morphogenesis (GO:0060997)2.27170699
191transcription elongation from RNA polymerase III promoter (GO:0006385)2.26638363
192termination of RNA polymerase III transcription (GO:0006386)2.26638363

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.34025719
2EZH2_22144423_ChIP-Seq_EOC_Human4.30246435
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.25804060
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.80975098
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.64355156
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.13558000
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.00999461
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.61873655
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.57937700
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.55520639
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54470688
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50799148
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.43086554
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.38705863
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.36074254
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.30747834
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.27487879
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.24845708
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.24741723
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.24273034
21IGF1R_20145208_ChIP-Seq_DFB_Human2.23100973
22* EST1_17652178_ChIP-ChIP_JURKAT_Human2.21705760
23GBX2_23144817_ChIP-Seq_PC3_Human2.16863667
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.15690726
25YY1_21170310_ChIP-Seq_MESCs_Mouse2.12866361
26REST_21632747_ChIP-Seq_MESCs_Mouse2.12072834
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.10708594
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.09765673
29* SRF_21415370_ChIP-Seq_HL-1_Mouse2.08825424
30RARB_27405468_Chip-Seq_BRAIN_Mouse2.08749076
31IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08669026
32DROSHA_22980978_ChIP-Seq_HELA_Human2.04683939
33MTF2_20144788_ChIP-Seq_MESCs_Mouse2.04450001
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02292799
35RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01318493
36EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01318493
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97659312
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.89768299
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.86254881
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86195816
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.85801564
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.85460600
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84916472
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84383872
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81253863
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75397862
47NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.69589831
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68946373
49* ZNF274_21170338_ChIP-Seq_K562_Hela1.68038323
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.67432675
51CIITA_25753668_ChIP-Seq_RAJI_Human1.64981863
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.61073157
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.61058122
54* BCL6_27268052_Chip-Seq_Bcells_Human1.60612387
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.59755116
56* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.57613082
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56249711
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56053432
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52425263
60VDR_23849224_ChIP-Seq_CD4+_Human1.51809085
61AR_21572438_ChIP-Seq_LNCaP_Human1.50774769
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.50042428
63* GABP_19822575_ChIP-Seq_HepG2_Human1.46398092
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.45930670
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.45627955
66ERA_21632823_ChIP-Seq_H3396_Human1.43868277
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42240896
68TAF15_26573619_Chip-Seq_HEK293_Human1.42209314
69P68_20966046_ChIP-Seq_HELA_Human1.41881703
70YY1_22570637_ChIP-Seq_MALME-3M_Human1.36739268
71FOXP3_21729870_ChIP-Seq_TREG_Human1.34735558
72* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.34415929
73SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.34395828
74* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.33410069
75OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.33244560
76CTCF_20526341_ChIP-Seq_ESCs_Human1.32681798
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.32609964
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32378010
79PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.31555543
80KDM2B_26808549_Chip-Seq_K562_Human1.31297248
81TET1_21451524_ChIP-Seq_MESCs_Mouse1.30786953
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29270641
83E2F1_20622854_ChIP-Seq_HELA_Human1.28905492
84BCOR_27268052_Chip-Seq_Bcells_Human1.28398501
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28156703
86IRF8_22096565_ChIP-ChIP_GC-B_Human1.23053127
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22979570
88WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21980131
89* FOXP1_21924763_ChIP-Seq_HESCs_Human1.20379780
90* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19842952
91ELF1_20517297_ChIP-Seq_JURKAT_Human1.19360512
92* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.18888176
93KDM5A_27292631_Chip-Seq_BREAST_Human1.18682306
94NANOG_20526341_ChIP-Seq_ESCs_Human1.18557088
95FOXA2_19822575_ChIP-Seq_HepG2_Human1.17919744
96CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.16271783
97ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14961164
98MYC_19829295_ChIP-Seq_ESCs_Human1.12409545
99CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11070103
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11051423
101RAC3_21632823_ChIP-Seq_H3396_Human1.10982384
102TAF2_19829295_ChIP-Seq_ESCs_Human1.10315670
103DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10097110
104SOX2_21211035_ChIP-Seq_LN229_Gbm1.09821242
105PHF8_20622854_ChIP-Seq_HELA_Human1.09368898
106TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08650111
107PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08375476
108SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07352572
109RING1B_27294783_Chip-Seq_ESCs_Mouse1.06814090
110ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05886197
111OCT4_20526341_ChIP-Seq_ESCs_Human1.05123089
112SA1_27219007_Chip-Seq_Bcells_Human1.04995723
113HTT_18923047_ChIP-ChIP_STHdh_Human1.04454825
114CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03756537
115* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02554417
116CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01620658
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00173075
118CTCF_26484167_Chip-Seq_Bcells_Mouse0.99523710
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99488761
120NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99045365
121SA1_27219007_Chip-Seq_ERYTHROID_Human0.98525519
122AR_19668381_ChIP-Seq_PC3_Human0.98419931
123* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98021322
124GATA3_21878914_ChIP-Seq_MCF-7_Human0.97954280
125RING1B_27294783_Chip-Seq_NPCs_Mouse0.97363021
126CTCF_27219007_Chip-Seq_Bcells_Human0.96902197
127BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94910098
128PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94849437
129XRN2_22483619_ChIP-Seq_HELA_Human0.94361249
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94022517
131ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94021269
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.93703995
133WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93634347
134STAT1_20625510_ChIP-Seq_HELA_Human0.93105927
135SPI1_20517297_ChIP-Seq_HL60_Human0.92396609
136P300_27268052_Chip-Seq_Bcells_Human0.92012883
137SMC4_20622854_ChIP-Seq_HELA_Human0.91169200
138PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90438126
139RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90370712
140* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90088987
141DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90010778
142MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88576495
143VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88111040
144* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87969341
145ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86888434
146GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86159162
147SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85991713
148ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85531075
149CREB1_15753290_ChIP-ChIP_HEK293T_Human0.85143227
150TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85011304
151TET1_21490601_ChIP-Seq_MESCs_Mouse0.84688636
152CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84568962
153SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82397028
154GATA1_22025678_ChIP-Seq_K562_Human0.81998394
155SMAD4_21799915_ChIP-Seq_A2780_Human0.81451037
156SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81426047
157MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.81169681
158OCT4_19829295_ChIP-Seq_ESCs_Human0.80859753
159CTCF_21964334_ChIP-Seq_BJAB-B_Human0.80590678
160LXR_22292898_ChIP-Seq_THP-1_Human0.80578510
161SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79870481
162RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.79806943
163CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78543266
164TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.78451220
165KLF4_19829295_ChIP-Seq_ESCs_Human0.78183445
166AR_25329375_ChIP-Seq_VCAP_Human0.77918762
167SMAD3_21741376_ChIP-Seq_EPCs_Human0.77224447
168STAT3_23295773_ChIP-Seq_U87_Human0.77043419
169ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76757991
170MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.76635336
171LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.76108935
172P53_22127205_ChIP-Seq_FIBROBLAST_Human0.74159317
173ZNF217_24962896_ChIP-Seq_MCF-7_Human0.73458713
174SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.71289139
175GATA1_26923725_Chip-Seq_HPCs_Mouse0.71119557
176ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.70238880
177EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.70047026

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.50168444
2MP0005360_urolithiasis3.45304633
3MP0005365_abnormal_bile_salt3.43290760
4MP0004859_abnormal_synaptic_plasticity3.40376928
5MP0002102_abnormal_ear_morphology3.12836302
6MP0005085_abnormal_gallbladder_physiolo3.04124530
7MP0004270_analgesia2.97128532
8MP0003635_abnormal_synaptic_transmissio2.69253481
9MP0002876_abnormal_thyroid_physiology2.51896378
10MP0008875_abnormal_xenobiotic_pharmacok2.33860142
11MP0002064_seizures2.32382038
12MP0003329_amyloid_beta_deposits2.18515127
13MP0009745_abnormal_behavioral_response2.11268080
14MP0003880_abnormal_central_pattern2.08868202
15MP0002272_abnormal_nervous_system2.05922910
16MP0006036_abnormal_mitochondrial_physio2.01119103
17MP0006072_abnormal_retinal_apoptosis1.98073661
18MP0003868_abnormal_feces_composition1.96814315
19MP0003252_abnormal_bile_duct1.96596157
20MP0009046_muscle_twitch1.94155059
21MP0010329_abnormal_lipoprotein_level1.89972764
22MP0001905_abnormal_dopamine_level1.88988948
23MP0005646_abnormal_pituitary_gland1.88295313
24MP0002909_abnormal_adrenal_gland1.86893387
25MP0002822_catalepsy1.84561098
26MP0003136_yellow_coat_color1.82295600
27MP0002063_abnormal_learning/memory/cond1.78744852
28MP0001486_abnormal_startle_reflex1.78195641
29MP0009840_abnormal_foam_cell1.76691105
30MP0005058_abnormal_lysosome_morphology1.74890894
31MP0003195_calcinosis1.73041208
32MP0002734_abnormal_mechanical_nocicepti1.71957411
33MP0005645_abnormal_hypothalamus_physiol1.70191208
34MP0001968_abnormal_touch/_nociception1.69782690
35MP0000778_abnormal_nervous_system1.66199133
36MP0002638_abnormal_pupillary_reflex1.64221800
37MP0002736_abnormal_nociception_after1.56294702
38MP0001188_hyperpigmentation1.56069883
39MP0004145_abnormal_muscle_electrophysio1.55446479
40MP0001666_abnormal_nutrient_absorption1.55161018
41MP0002735_abnormal_chemical_nociception1.53299263
42MP0002163_abnormal_gland_morphology1.51236810
43MP0005083_abnormal_biliary_tract1.50990496
44MP0005253_abnormal_eye_physiology1.50186743
45MP0002572_abnormal_emotion/affect_behav1.49192045
46MP0002184_abnormal_innervation1.47721561
47MP0005332_abnormal_amino_acid1.47277462
48MP0004133_heterotaxia1.46675747
49MP0004811_abnormal_neuron_physiology1.46109762
50MP0000920_abnormal_myelination1.45701657
51MP0002118_abnormal_lipid_homeostasis1.43610533
52MP0003787_abnormal_imprinting1.42541519
53MP0002067_abnormal_sensory_capabilities1.39656198
54MP0008877_abnormal_DNA_methylation1.38899897
55MP0005410_abnormal_fertilization1.38728737
56MP0003806_abnormal_nucleotide_metabolis1.38510609
57MP0001764_abnormal_homeostasis1.35396199
58MP0008872_abnormal_physiological_respon1.34840295
59MP0005423_abnormal_somatic_nervous1.34641649
60MP0003191_abnormal_cellular_cholesterol1.34567176
61MP0000955_abnormal_spinal_cord1.34468335
62MP0000538_abnormal_urinary_bladder1.33940156
63MP0004043_abnormal_pH_regulation1.32767830
64MP0002837_dystrophic_cardiac_calcinosis1.32649350
65MP0008569_lethality_at_weaning1.30996669
66MP0002557_abnormal_social/conspecific_i1.30799641
67MP0001756_abnormal_urination1.29894546
68MP0004885_abnormal_endolymph1.28166138
69MP0003011_delayed_dark_adaptation1.27621604
70MP0002733_abnormal_thermal_nociception1.26035483
71MP0001984_abnormal_olfaction1.24819471
72MP0005386_behavior/neurological_phenoty1.24667692
73MP0004924_abnormal_behavior1.24667692
74MP0003315_abnormal_perineum_morphology1.20198296
75MP0003690_abnormal_glial_cell1.20174279
76MP0005584_abnormal_enzyme/coenzyme_acti1.19037107
77MP0000013_abnormal_adipose_tissue1.18339167
78MP0002234_abnormal_pharynx_morphology1.18098933
79MP0010386_abnormal_urinary_bladder1.15515467
80MP0005394_taste/olfaction_phenotype1.13843084
81MP0005499_abnormal_olfactory_system1.13843084
82MP0006276_abnormal_autonomic_nervous1.13438419
83MP0005379_endocrine/exocrine_gland_phen1.12846207
84MP0005535_abnormal_body_temperature1.12778416
85MP0002653_abnormal_ependyma_morphology1.12632159
86MP0002882_abnormal_neuron_morphology1.12351480
87MP0003879_abnormal_hair_cell1.12178883
88MP0003186_abnormal_redox_activity1.12040011
89MP0004142_abnormal_muscle_tone1.11413951
90MP0001970_abnormal_pain_threshold1.10292560
91MP0000604_amyloidosis1.08928371
92MP0009780_abnormal_chondrocyte_physiolo1.06266958
93MP0002229_neurodegeneration1.05990437
94MP0002066_abnormal_motor_capabilities/c1.05847325
95MP0003633_abnormal_nervous_system1.05575626
96MP0004858_abnormal_nervous_system1.05020370
97MP0000751_myopathy1.04124915
98MP0001502_abnormal_circadian_rhythm1.01612989
99MP0006035_abnormal_mitochondrial_morpho1.00755111
100MP0008789_abnormal_olfactory_epithelium1.00411400
101MP0002277_abnormal_respiratory_mucosa1.00346609
102MP0000747_muscle_weakness0.99957576
103MP0001270_distended_abdomen0.99820434
104MP0004742_abnormal_vestibular_system0.98380465
105MP0002069_abnormal_eating/drinking_beha0.98363586
106MP0005084_abnormal_gallbladder_morpholo0.97413242
107MP0003646_muscle_fatigue0.97248125
108MP0002160_abnormal_reproductive_system0.96620175
109MP0004130_abnormal_muscle_cell0.96614163
110MP0000685_abnormal_immune_system0.96566455
111MP0001944_abnormal_pancreas_morphology0.95860924
112MP0000631_abnormal_neuroendocrine_gland0.95768804
113MP0005075_abnormal_melanosome_morpholog0.94953108
114MP0002078_abnormal_glucose_homeostasis0.94740843
115MP0003631_nervous_system_phenotype0.91065213
116MP0003656_abnormal_erythrocyte_physiolo0.90875772
117MP0001485_abnormal_pinna_reflex0.89431761
118MP0009764_decreased_sensitivity_to0.88505694
119MP0004085_abnormal_heartbeat0.87658013
120MP0003221_abnormal_cardiomyocyte_apopto0.85627238
121MP0005167_abnormal_blood-brain_barrier0.85554717
122MP0005551_abnormal_eye_electrophysiolog0.85552224
123MP0003634_abnormal_glial_cell0.83871673
124MP0008874_decreased_physiological_sensi0.83699451
125MP0005671_abnormal_response_to0.83325345
126MP0001440_abnormal_grooming_behavior0.83311632
127MP0001986_abnormal_taste_sensitivity0.80697039
128MP0000003_abnormal_adipose_tissue0.80499317
129MP0003632_abnormal_nervous_system0.80051079
130MP0002152_abnormal_brain_morphology0.79665453
131MP0000609_abnormal_liver_physiology0.79660403
132MP0001963_abnormal_hearing_physiology0.78747386
133MP0002752_abnormal_somatic_nervous0.77667480
134MP0002751_abnormal_autonomic_nervous0.75894679
135MP0008961_abnormal_basal_metabolism0.75508057
136MP0002693_abnormal_pancreas_physiology0.74344251
137MP0001348_abnormal_lacrimal_gland0.74126501
138MP0004147_increased_porphyrin_level0.73774870
139MP0001529_abnormal_vocalization0.72555566
140MP0000534_abnormal_ureter_morphology0.72444302
141MP0003137_abnormal_impulse_conducting0.70922114
142MP0003172_abnormal_lysosome_physiology0.70354851

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.02687595
2Hepatocellular necrosis (HP:0001404)4.22177380
3Hepatic necrosis (HP:0002605)4.09068394
4Mitochondrial inheritance (HP:0001427)4.03709098
5Acute necrotizing encephalopathy (HP:0006965)4.00485070
6Intrahepatic cholestasis (HP:0001406)3.87967846
7Abnormal mitochondria in muscle tissue (HP:0008316)3.86270368
8Acute encephalopathy (HP:0006846)3.67065151
9Deep venous thrombosis (HP:0002625)3.64596571
10Hyperlipoproteinemia (HP:0010980)3.55419173
11Ketosis (HP:0001946)3.46741206
12Progressive macrocephaly (HP:0004481)3.42765085
13Focal motor seizures (HP:0011153)3.42652154
14Increased CSF lactate (HP:0002490)3.39825779
15Ketoacidosis (HP:0001993)3.29910297
16Pheochromocytoma (HP:0002666)3.27406219
17Hyperventilation (HP:0002883)3.26146877
18Myokymia (HP:0002411)3.23709627
19Abnormality of fatty-acid metabolism (HP:0004359)3.19321139
20Polyphagia (HP:0002591)3.17642153
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.16229403
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.16229403
23Ankle clonus (HP:0011448)3.09007756
24Spastic gait (HP:0002064)3.05433230
25Renal Fanconi syndrome (HP:0001994)3.03557749
263-Methylglutaconic aciduria (HP:0003535)3.00109204
27Conjugated hyperbilirubinemia (HP:0002908)2.93669170
28Pancreatic fibrosis (HP:0100732)2.93612671
29Reduced antithrombin III activity (HP:0001976)2.89965583
30Hypoglycemic coma (HP:0001325)2.87979235
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.87192327
32Pancreatic cysts (HP:0001737)2.86423539
33Centrally nucleated skeletal muscle fibers (HP:0003687)2.83786011
34Neuroendocrine neoplasm (HP:0100634)2.80705665
35Medial flaring of the eyebrow (HP:0010747)2.80684850
36Xanthomatosis (HP:0000991)2.78731870
37Death in childhood (HP:0003819)2.77552019
38Hypobetalipoproteinemia (HP:0003563)2.77340955
39Focal seizures (HP:0007359)2.74708843
40Lipid accumulation in hepatocytes (HP:0006561)2.70245516
41Visual hallucinations (HP:0002367)2.68528101
42Abnormality of monocarboxylic acid metabolism (HP:0010996)2.66413303
43Nephronophthisis (HP:0000090)2.63170692
44Lactic acidosis (HP:0003128)2.62054717
45Neurofibrillary tangles (HP:0002185)2.59150861
46Increased muscle lipid content (HP:0009058)2.58877376
47Increased intramyocellular lipid droplets (HP:0012240)2.58419059
48Turricephaly (HP:0000262)2.57540341
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.56282726
50Hyperammonemia (HP:0001987)2.55997128
51Abnormal protein glycosylation (HP:0012346)2.53802838
52Abnormal glycosylation (HP:0012345)2.53802838
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.53802838
54Abnormal protein N-linked glycosylation (HP:0012347)2.53802838
55Prolonged partial thromboplastin time (HP:0003645)2.52500321
56Clonus (HP:0002169)2.48746381
57Increased hepatocellular lipid droplets (HP:0006565)2.48112259
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.48111381
59Opisthotonus (HP:0002179)2.46999763
60Dicarboxylic aciduria (HP:0003215)2.44046049
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.44046049
62Abnormality of midbrain morphology (HP:0002418)2.43263836
63Molar tooth sign on MRI (HP:0002419)2.43263836
64Anxiety (HP:0000739)2.43020648
65Methylmalonic aciduria (HP:0012120)2.41127241
66Cerebral hypomyelination (HP:0006808)2.40313221
67Action tremor (HP:0002345)2.39128868
68Optic disc pallor (HP:0000543)2.38074351
69Hyperinsulinemic hypoglycemia (HP:0000825)2.37537667
70Type I transferrin isoform profile (HP:0003642)2.37147183
71Gout (HP:0001997)2.35443532
72Cerebral edema (HP:0002181)2.33924423
73Abnormal social behavior (HP:0012433)2.33853822
74Impaired social interactions (HP:0000735)2.33853822
75Delayed CNS myelination (HP:0002188)2.31636923
76Exercise intolerance (HP:0003546)2.31283252
77Impaired smooth pursuit (HP:0007772)2.30827768
78Hypoglycemic seizures (HP:0002173)2.30556411
79Increased serum lactate (HP:0002151)2.28281337
80Complement deficiency (HP:0004431)2.27547435
81Respiratory failure (HP:0002878)2.27206220
82Late onset (HP:0003584)2.27087303
83Renal cortical cysts (HP:0000803)2.26773499
84Gait imbalance (HP:0002141)2.26078947
85Lethargy (HP:0001254)2.22509425
86True hermaphroditism (HP:0010459)2.22347051
87Emotional lability (HP:0000712)2.22112984
88EEG with generalized epileptiform discharges (HP:0011198)2.19656485
89Hypothermia (HP:0002045)2.18956949
90Supranuclear gaze palsy (HP:0000605)2.18615384
91Abnormal respiratory epithelium morphology (HP:0012253)2.18409471
92Abnormal respiratory motile cilium morphology (HP:0005938)2.18409471
93Poor eye contact (HP:0000817)2.18159957
94Abnormal biliary tract physiology (HP:0012439)2.17559184
95Bile duct proliferation (HP:0001408)2.17559184
96CNS demyelination (HP:0007305)2.17047940
97Fair hair (HP:0002286)2.14442247
98Large for gestational age (HP:0001520)2.14327204
99Aplasia/hypoplasia of the uterus (HP:0008684)2.14090621
100Hyperbilirubinemia (HP:0002904)2.13394467
101Epileptiform EEG discharges (HP:0011182)2.13190252
102Epileptic encephalopathy (HP:0200134)2.12945304
103Neonatal onset (HP:0003623)2.12725205
104Intention tremor (HP:0002080)2.12462178
105Absent/shortened dynein arms (HP:0200106)2.12247759
106Dynein arm defect of respiratory motile cilia (HP:0012255)2.12247759
107Cerebral inclusion bodies (HP:0100314)2.12116946
108Hyperglycinemia (HP:0002154)2.12065231
109Blue irides (HP:0000635)2.11865551
110Epidermoid cyst (HP:0200040)2.11851455
111Hypsarrhythmia (HP:0002521)2.11308902
112Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.10809378
113Abnormality of the intrinsic pathway (HP:0010989)2.09143461
114Abnormality of the corticospinal tract (HP:0002492)2.08811329
115Abnormality of the common coagulation pathway (HP:0010990)2.08266590
116Abnormality of the renal medulla (HP:0100957)2.07771486
117Progressive inability to walk (HP:0002505)2.07204872
118Congenital primary aphakia (HP:0007707)2.06007724
119Protruding tongue (HP:0010808)2.05832746
120Hyperglycinuria (HP:0003108)2.05651569
121Generalized hypopigmentation of hair (HP:0011358)2.02413016
122Hypolipoproteinemia (HP:0010981)2.02182793
123Progressive microcephaly (HP:0000253)2.01766659
124Occipital encephalocele (HP:0002085)2.01645425
125Dysmetria (HP:0001310)2.00858151
126Agitation (HP:0000713)2.00605052
127Type II lissencephaly (HP:0007260)2.00417008
128Inability to walk (HP:0002540)2.00297047
129Abnormality of ocular smooth pursuit (HP:0000617)1.99476715
130Chronic hepatic failure (HP:0100626)1.99258373
131Aplasia/Hypoplasia of the brainstem (HP:0007362)1.98876576
132Hypoplasia of the brainstem (HP:0002365)1.98876576
133Abnormal gallbladder physiology (HP:0012438)1.98422840
134Cholecystitis (HP:0001082)1.98422840
135Poor suck (HP:0002033)1.97289456
136CNS hypomyelination (HP:0003429)1.96248159
137Abnormality of serine family amino acid metabolism (HP:0010894)1.95881642
138Abnormality of glycine metabolism (HP:0010895)1.95881642
139Megalencephaly (HP:0001355)1.95226215
140Hemiparesis (HP:0001269)1.94266650
141Sclerocornea (HP:0000647)1.94063970
142Lower limb muscle weakness (HP:0007340)1.93203890
143Nonprogressive disorder (HP:0003680)1.92895963
144Generalized tonic-clonic seizures (HP:0002069)1.92802236
145Abnormal ciliary motility (HP:0012262)1.92579073
146Nephrogenic diabetes insipidus (HP:0009806)1.91363451
147Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.91162744
148Cystic liver disease (HP:0006706)1.90871408
149Pachygyria (HP:0001302)1.90582376
150Status epilepticus (HP:0002133)1.89662757
151Progressive cerebellar ataxia (HP:0002073)1.89019142
152Focal dystonia (HP:0004373)1.87782744
153Impaired vibration sensation in the lower limbs (HP:0002166)1.87429190
154Polydipsia (HP:0001959)1.87172313
155Abnormal drinking behavior (HP:0030082)1.87172313
156Retinal dysplasia (HP:0007973)1.86716270
157Torticollis (HP:0000473)1.86638865
158Depression (HP:0000716)1.86107024
159Abnormality of the renal cortex (HP:0011035)1.86058949
160Restlessness (HP:0000711)1.85974378
161Abnormal respiratory motile cilium physiology (HP:0012261)1.85708533
162Thyroid-stimulating hormone excess (HP:0002925)1.85519892
163Abnormality of lateral ventricle (HP:0030047)1.85273061
164Abnormality of glycolipid metabolism (HP:0010969)1.84756941
165Abnormality of liposaccharide metabolism (HP:0010968)1.84756941
166Abnormality of glycosphingolipid metabolism (HP:0004343)1.84756941
167Methylmalonic acidemia (HP:0002912)1.84669845
168Facial shape deformation (HP:0011334)1.84329001
169Potter facies (HP:0002009)1.84329001
170Atonic seizures (HP:0010819)1.83908444
171Generalized aminoaciduria (HP:0002909)1.83791879
172Hypoventilation (HP:0002791)1.83431086
173Cerebral hemorrhage (HP:0001342)1.83026320
174Symptomatic seizures (HP:0011145)1.81811399
175Leukodystrophy (HP:0002415)1.81537552
176Abnormality of sulfur amino acid metabolism (HP:0004339)1.81238652
177Joint hemorrhage (HP:0005261)1.81154903
178Abnormal eating behavior (HP:0100738)1.80947985
179Craniofacial dystonia (HP:0012179)1.80698683
180Hypoalphalipoproteinemia (HP:0003233)1.80237697
181Severe muscular hypotonia (HP:0006829)1.79822675
182Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79821253
183Fetal akinesia sequence (HP:0001989)1.78807712
184Cerebral palsy (HP:0100021)1.78182917
185Amblyopia (HP:0000646)1.75977137
186Abolished electroretinogram (ERG) (HP:0000550)1.73097748

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K46.19467156
2MAP2K75.84233999
3MAP2K44.19023123
4TLK13.64675710
5MARK13.47799965
6MAPKAPK32.65494527
7MAP4K22.59113289
8STK162.56849329
9MARK32.36274742
10BMPR1B2.34998074
11DAPK22.22041664
12RET2.02122372
13ZAK1.89333798
14MAP3K111.79884537
15VRK21.72497914
16NTRK21.70183244
17CDK31.63547016
18VRK11.61885028
19PIM21.60174776
20SGK2231.59323149
21SGK4941.59323149
22TAOK31.58100276
23BCKDK1.57643429
24UHMK11.51611730
25CAMK1G1.45510204
26MINK11.43169848
27TNK21.41058994
28FGFR41.40726292
29NTRK31.38843957
30TAOK11.35557672
31ADRBK21.35471263
32FGFR21.34094407
33EEF2K1.33139851
34CAMKK21.31457984
35CSNK1G31.29186388
36CSNK1G21.28927972
37EPHA41.27736466
38TRIB31.26410242
39MAP4K11.26311718
40CASK1.25324339
41MARK21.23416744
42DYRK21.22093715
43SGK21.21678960
44PRPF4B1.16186110
45OXSR11.15852937
46NTRK11.15152279
47FRK1.14931070
48DAPK11.13974276
49CSNK1A1L1.12001403
50MAPK151.11205135
51FES1.10707969
52INSRR1.09067703
53PTK61.08808148
54CDK51.08717129
55SRPK11.04950235
56CAMKK11.01163083
57MAP3K70.99651359
58CSNK1G10.97454059
59MAPK130.95828598
60SGK30.95557109
61CAMK1D0.95097108
62HIPK20.94838686
63TESK10.94660220
64PAK60.92619415
65RPS6KA50.91926541
66OBSCN0.89822042
67PHKG10.89179799
68PHKG20.89179799
69CAMK2B0.88183873
70WNK30.87952194
71EPHB10.87722857
72TYRO30.84438737
73PINK10.82423278
74TXK0.81285210
75MAPKAPK50.80349724
76SIK20.80243612
77GRK10.79830906
78NME10.79746789
79MAP3K60.79549708
80SIK10.78895860
81MAPK120.78081104
82EPHA30.77805607
83CAMK2G0.77617118
84TESK20.77478261
85CDK190.77015138
86STK390.76638490
87CAMK2D0.76180957
88PRKCH0.73090195
89CSNK1A10.70522687
90GRK60.69419546
91ERBB40.64889964
92ICK0.62184044
93MAP3K20.62144128
94MUSK0.61750742
95LIMK10.61482922
96CAMK10.60544545
97KSR10.60535003
98PDGFRA0.60392723
99ERN10.60255688
100MAP3K90.58982183
101CAMK40.56986945
102MAP3K50.56864035
103PAK30.55844154
104PRKCG0.55594037
105MYLK0.54516773
106NUAK10.54468231
107PKN10.54269649
108IRAK20.54201153
109CDK80.53466520
110NME20.51703648
111YES10.51681287
112NEK20.49685271
113MAP2K60.49054018
114ABL20.48706173
115RPS6KA20.48628938
116PRKCQ0.48335822
117PRKD30.48198247
118PRKD20.48166466
119ROCK20.47905007
120PASK0.47582952
121IKBKB0.46496352
122ERBB20.46420114
123CDK150.45755660
124CAMK2A0.45602636
125CDK180.45406478
126ARAF0.45059987
127KSR20.44937678
128TGFBR10.43223313
129PRKCZ0.42761419
130AKT30.42293379
131DYRK1A0.42120366
132CDK140.41373773
133DYRK1B0.41000959
134SYK0.40473121
135WNK40.40428453
136MAP3K10.39509742
137MAP3K120.39418358
138PRKACA0.38954564
139BTK0.38504571
140PRKCE0.38433401
141PDK20.38340435
142GRK50.37512278
143CSF1R0.37443166
144PNCK0.36485138
145PRKAA10.35762541
146FLT30.35728976
147AKT20.34982435
148TRPM70.34905767
149PRKCI0.34887269
150CDK11A0.34838782
151CSNK1D0.34815059
152DAPK30.34791147
153BCR0.34698956
154STK380.34261816
155TBK10.33796049
156SCYL20.33353253
157ILK0.33286419
158CCNB10.32854020

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.83857419
2Sulfur relay system_Homo sapiens_hsa041223.23729947
3Parkinsons disease_Homo sapiens_hsa050123.20270830
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.18198305
5Nitrogen metabolism_Homo sapiens_hsa009103.12444096
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.50361185
7Butanoate metabolism_Homo sapiens_hsa006502.50115674
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.49227523
9Collecting duct acid secretion_Homo sapiens_hsa049662.48866961
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.45936564
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.30767064
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.30748000
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21069809
14Arginine biosynthesis_Homo sapiens_hsa002202.11720997
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.02019652
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.95958673
17Alzheimers disease_Homo sapiens_hsa050101.94863384
18Fatty acid degradation_Homo sapiens_hsa000711.89080183
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.86132625
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.85342089
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.81861964
22Tryptophan metabolism_Homo sapiens_hsa003801.81091545
23Huntingtons disease_Homo sapiens_hsa050161.81000757
24RNA polymerase_Homo sapiens_hsa030201.80332810
25GABAergic synapse_Homo sapiens_hsa047271.67727253
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63375730
27Propanoate metabolism_Homo sapiens_hsa006401.62590955
28Fatty acid metabolism_Homo sapiens_hsa012121.53119879
29Fatty acid elongation_Homo sapiens_hsa000621.52058372
30Synaptic vesicle cycle_Homo sapiens_hsa047211.50585767
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.48755394
32Cardiac muscle contraction_Homo sapiens_hsa042601.46912679
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40263345
34Peroxisome_Homo sapiens_hsa041461.40087496
35Pyruvate metabolism_Homo sapiens_hsa006201.38577008
36Regulation of autophagy_Homo sapiens_hsa041401.37245772
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37095429
38Bile secretion_Homo sapiens_hsa049761.36363417
39Nicotine addiction_Homo sapiens_hsa050331.36054740
40Type II diabetes mellitus_Homo sapiens_hsa049301.34788306
41Histidine metabolism_Homo sapiens_hsa003401.34261922
42Sulfur metabolism_Homo sapiens_hsa009201.30868252
43Insulin secretion_Homo sapiens_hsa049111.30636859
44Proteasome_Homo sapiens_hsa030501.28335729
45Circadian entrainment_Homo sapiens_hsa047131.27810748
46Glutamatergic synapse_Homo sapiens_hsa047241.24498566
47Protein export_Homo sapiens_hsa030601.23714375
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22896561
49Complement and coagulation cascades_Homo sapiens_hsa046101.22544057
50Morphine addiction_Homo sapiens_hsa050321.22293330
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21907698
52Phototransduction_Homo sapiens_hsa047441.18878153
53Dopaminergic synapse_Homo sapiens_hsa047281.17465778
54Type I diabetes mellitus_Homo sapiens_hsa049401.16010990
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08635875
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07997996
57Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07503753
58PPAR signaling pathway_Homo sapiens_hsa033201.05096265
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02938045
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.01959360
61Cocaine addiction_Homo sapiens_hsa050301.01919416
62beta-Alanine metabolism_Homo sapiens_hsa004101.01181407
63Base excision repair_Homo sapiens_hsa034100.99783234
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.96567351
65Olfactory transduction_Homo sapiens_hsa047400.96173745
66Purine metabolism_Homo sapiens_hsa002300.95736812
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95127187
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.95013261
69Cholinergic synapse_Homo sapiens_hsa047250.93925742
70ABC transporters_Homo sapiens_hsa020100.92501416
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92180336
72Amphetamine addiction_Homo sapiens_hsa050310.90817455
73* Metabolic pathways_Homo sapiens_hsa011000.90340456
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90291219
75Pyrimidine metabolism_Homo sapiens_hsa002400.86941940
76Rheumatoid arthritis_Homo sapiens_hsa053230.86089820
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85447569
78Asthma_Homo sapiens_hsa053100.84121434
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.80254560
80Starch and sucrose metabolism_Homo sapiens_hsa005000.78026238
81Taste transduction_Homo sapiens_hsa047420.76968796
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76495193
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74492474
84Tyrosine metabolism_Homo sapiens_hsa003500.72875972
85Chemical carcinogenesis_Homo sapiens_hsa052040.72525134
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71988315
87Selenocompound metabolism_Homo sapiens_hsa004500.71256017
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70923449
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70777875
90Phenylalanine metabolism_Homo sapiens_hsa003600.70562017
91Retinol metabolism_Homo sapiens_hsa008300.70357784
92Biosynthesis of amino acids_Homo sapiens_hsa012300.69697119
93Ribosome_Homo sapiens_hsa030100.68911110
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68195484
95Prion diseases_Homo sapiens_hsa050200.66524780
96Steroid biosynthesis_Homo sapiens_hsa001000.66306963
97Vibrio cholerae infection_Homo sapiens_hsa051100.66201063
98Long-term potentiation_Homo sapiens_hsa047200.65057336
99Insulin resistance_Homo sapiens_hsa049310.63977715
100Serotonergic synapse_Homo sapiens_hsa047260.62686848
101Gastric acid secretion_Homo sapiens_hsa049710.62043997
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61892317
103Phagosome_Homo sapiens_hsa041450.61620214
104Lysine degradation_Homo sapiens_hsa003100.59018397
105Lysosome_Homo sapiens_hsa041420.58709887
106Other glycan degradation_Homo sapiens_hsa005110.58324977
107ErbB signaling pathway_Homo sapiens_hsa040120.57579633
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56915889
109Carbon metabolism_Homo sapiens_hsa012000.56181668
110Renin secretion_Homo sapiens_hsa049240.55731800
111Autoimmune thyroid disease_Homo sapiens_hsa053200.55198410
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.54778907
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54382170
114Axon guidance_Homo sapiens_hsa043600.54118199
115Salivary secretion_Homo sapiens_hsa049700.53825274
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53358123
117Allograft rejection_Homo sapiens_hsa053300.51364327
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50629853
119Arginine and proline metabolism_Homo sapiens_hsa003300.49903642
120Mineral absorption_Homo sapiens_hsa049780.49705713
121Fat digestion and absorption_Homo sapiens_hsa049750.49232748
122Arachidonic acid metabolism_Homo sapiens_hsa005900.47082933
123Vitamin B6 metabolism_Homo sapiens_hsa007500.45535935
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.45296126
125Glucagon signaling pathway_Homo sapiens_hsa049220.43975291
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43964914
127Long-term depression_Homo sapiens_hsa047300.43553548
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43210063
129Folate biosynthesis_Homo sapiens_hsa007900.42378305
130cAMP signaling pathway_Homo sapiens_hsa040240.42023983
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42013091
132Non-homologous end-joining_Homo sapiens_hsa034500.41681297
133Glutathione metabolism_Homo sapiens_hsa004800.41267793
134Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40035177
135GnRH signaling pathway_Homo sapiens_hsa049120.39467467
136Intestinal immune network for IgA production_Homo sapiens_hsa046720.39120904
137RNA degradation_Homo sapiens_hsa030180.38824383
138Gap junction_Homo sapiens_hsa045400.38498744
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.38456889
140Oxytocin signaling pathway_Homo sapiens_hsa049210.38455247
141Glycerolipid metabolism_Homo sapiens_hsa005610.37953965
142Linoleic acid metabolism_Homo sapiens_hsa005910.37302628
143Alcoholism_Homo sapiens_hsa050340.36609618
144Graft-versus-host disease_Homo sapiens_hsa053320.34693935
145Calcium signaling pathway_Homo sapiens_hsa040200.34382659
146Insulin signaling pathway_Homo sapiens_hsa049100.34153085

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