THUMPD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.07266912
2maturation of SSU-rRNA (GO:0030490)4.55127614
3ribosomal small subunit biogenesis (GO:0042274)4.14271681
4DNA deamination (GO:0045006)4.04268763
5ribosomal large subunit biogenesis (GO:0042273)3.98640277
6viral transcription (GO:0019083)3.96350993
7translational termination (GO:0006415)3.90686230
8telomere maintenance via semi-conservative replication (GO:0032201)3.90589829
9DNA strand elongation involved in DNA replication (GO:0006271)3.85286660
10chromatin remodeling at centromere (GO:0031055)3.79918712
11regulation of centriole replication (GO:0046599)3.79078230
12CENP-A containing nucleosome assembly (GO:0034080)3.78877909
13DNA replication initiation (GO:0006270)3.77024431
14DNA strand elongation (GO:0022616)3.72708085
15nuclear pore organization (GO:0006999)3.72297429
16telomere maintenance via recombination (GO:0000722)3.64852669
17mitotic sister chromatid cohesion (GO:0007064)3.62678197
18mitotic sister chromatid segregation (GO:0000070)3.54222681
19kinetochore organization (GO:0051383)3.53389733
20ribonucleoprotein complex biogenesis (GO:0022613)3.49005452
21DNA replication checkpoint (GO:0000076)3.45135397
22ribosome assembly (GO:0042255)3.42043103
23regulation of DNA endoreduplication (GO:0032875)3.41725302
24sister chromatid segregation (GO:0000819)3.40445790
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.40245184
26mitotic recombination (GO:0006312)3.39222626
27translational elongation (GO:0006414)3.36922430
28cotranslational protein targeting to membrane (GO:0006613)3.34821859
29regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.33451586
30mitotic chromosome condensation (GO:0007076)3.31507422
31histone exchange (GO:0043486)3.30949369
32protein targeting to ER (GO:0045047)3.30161201
33rRNA methylation (GO:0031167)3.27933846
34proteasome assembly (GO:0043248)3.27337492
35nucleotide-excision repair, DNA gap filling (GO:0006297)3.26226229
36protein localization to kinetochore (GO:0034501)3.26039749
37DNA ligation (GO:0006266)3.25424919
38rRNA processing (GO:0006364)3.24836391
39regulation of centrosome cycle (GO:0046605)3.22415143
40mitotic nuclear envelope disassembly (GO:0007077)3.20945294
41telomere maintenance via telomere lengthening (GO:0010833)3.20893165
42pseudouridine synthesis (GO:0001522)3.20563261
43DNA replication-independent nucleosome organization (GO:0034724)3.20469228
44DNA replication-independent nucleosome assembly (GO:0006336)3.20469228
45replication fork processing (GO:0031297)3.19865395
46rRNA metabolic process (GO:0016072)3.18980718
47kinetochore assembly (GO:0051382)3.18825768
48mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.15267080
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.14725349
50purine nucleobase biosynthetic process (GO:0009113)3.13995025
51sperm-egg recognition (GO:0035036)3.11981077
52establishment of protein localization to endoplasmic reticulum (GO:0072599)3.11370477
53viral mRNA export from host cell nucleus (GO:0046784)3.10376939
54translational initiation (GO:0006413)3.09879914
55protein localization to endoplasmic reticulum (GO:0070972)3.09863852
56cellular protein complex disassembly (GO:0043624)3.09176152
57regulation of mitochondrial translation (GO:0070129)3.08375190
58transcription elongation from RNA polymerase I promoter (GO:0006362)3.08028383
59ribosome biogenesis (GO:0042254)3.06444071
60regulation of translational fidelity (GO:0006450)3.05982850
61establishment of protein localization to mitochondrial membrane (GO:0090151)3.04864911
62folic acid-containing compound biosynthetic process (GO:0009396)3.04717237
63synapsis (GO:0007129)3.03810647
64viral life cycle (GO:0019058)3.03694414
65protein localization to chromosome, centromeric region (GO:0071459)3.03257255
66non-recombinational repair (GO:0000726)3.01446558
67double-strand break repair via nonhomologous end joining (GO:0006303)3.01446558
68pore complex assembly (GO:0046931)2.99537130
69mitotic metaphase plate congression (GO:0007080)2.99489772
70rRNA modification (GO:0000154)2.98300212
71amino acid activation (GO:0043038)2.97757652
72tRNA aminoacylation (GO:0043039)2.97757652
73microtubule depolymerization (GO:0007019)2.97647614
74termination of RNA polymerase I transcription (GO:0006363)2.97280832
75tRNA aminoacylation for protein translation (GO:0006418)2.95589844
76meiotic chromosome segregation (GO:0045132)2.95009458
77transcription-coupled nucleotide-excision repair (GO:0006283)2.94189095
78binding of sperm to zona pellucida (GO:0007339)2.93451409
79IMP biosynthetic process (GO:0006188)2.92941740
80nuclear envelope disassembly (GO:0051081)2.91728883
81membrane disassembly (GO:0030397)2.91728883
82exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.91389965
83spliceosomal snRNP assembly (GO:0000387)2.91363986
84DNA topological change (GO:0006265)2.90378451
85telomere maintenance via telomerase (GO:0007004)2.88761625
86DNA strand renaturation (GO:0000733)2.88653456
87protein K6-linked ubiquitination (GO:0085020)2.88438417
88formation of translation preinitiation complex (GO:0001731)2.88075170
89establishment of integrated proviral latency (GO:0075713)2.86391460
90spindle checkpoint (GO:0031577)2.86364716
91regulation of centrosome duplication (GO:0010824)2.85713465
92transcription elongation from RNA polymerase III promoter (GO:0006385)2.85503385
93termination of RNA polymerase III transcription (GO:0006386)2.85503385
94anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85370104
95somatic hypermutation of immunoglobulin genes (GO:0016446)2.84935132
96somatic diversification of immune receptors via somatic mutation (GO:0002566)2.84935132
97metaphase plate congression (GO:0051310)2.84451146
98mismatch repair (GO:0006298)2.83947435
99regulation of mitotic spindle checkpoint (GO:1903504)2.83519497
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.83519497
101water-soluble vitamin biosynthetic process (GO:0042364)2.82914583
102DNA double-strand break processing (GO:0000729)2.82427255
103regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82259294
104DNA catabolic process, exonucleolytic (GO:0000738)2.81875713
105nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80970213
106positive regulation of chromosome segregation (GO:0051984)2.79065228
107mitotic spindle checkpoint (GO:0071174)2.77958354
108negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.77948292
109tRNA methylation (GO:0030488)2.77685282
110telomere organization (GO:0032200)2.77522993
111translation (GO:0006412)2.77404658
112maturation of 5.8S rRNA (GO:0000460)2.76666202
113telomere maintenance (GO:0000723)2.76475724
114cellular component biogenesis (GO:0044085)2.75936105
115cell-cell recognition (GO:0009988)2.75798097
116somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.75566848
117isotype switching (GO:0045190)2.75566848
118somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.75566848
119regulation of chromosome segregation (GO:0051983)2.75508778
120DNA replication-dependent nucleosome organization (GO:0034723)2.75213421
121DNA replication-dependent nucleosome assembly (GO:0006335)2.75213421
122ATP synthesis coupled proton transport (GO:0015986)2.75080669
123energy coupled proton transport, down electrochemical gradient (GO:0015985)2.75080669
124nucleobase biosynthetic process (GO:0046112)2.74732477
125transcription from RNA polymerase I promoter (GO:0006360)2.74391603
126intra-S DNA damage checkpoint (GO:0031573)2.74269311
127histone mRNA metabolic process (GO:0008334)2.73118232
128DNA unwinding involved in DNA replication (GO:0006268)2.72444184
129DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.72340316
130male meiosis (GO:0007140)2.71934981
131positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.71669589
132postreplication repair (GO:0006301)2.71621146
133signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.70449590
134signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.70449590
135signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.70449590
136intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.70357737
137signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.70357737
138protein complex disassembly (GO:0043241)2.70107792
139regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.69981089
140negative regulation of chromosome segregation (GO:0051985)2.69961246
141deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.69918033
142ncRNA processing (GO:0034470)2.69316277
143chromosome organization involved in meiosis (GO:0070192)2.69251961
1447-methylguanosine mRNA capping (GO:0006370)2.68850515
145RNA capping (GO:0036260)2.68559123
1467-methylguanosine RNA capping (GO:0009452)2.68559123
147chromosome segregation (GO:0007059)2.67961473
148regulation of nuclear cell cycle DNA replication (GO:0033262)2.67928929
149nuclear-transcribed mRNA catabolic process (GO:0000956)2.67743263
150ncRNA metabolic process (GO:0034660)2.66767221
151nuclear pore complex assembly (GO:0051292)2.66553732
152IMP metabolic process (GO:0046040)2.66133434
153negative regulation of mitotic sister chromatid separation (GO:2000816)2.65855264
154negative regulation of sister chromatid segregation (GO:0033046)2.65855264
155negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.65855264
156negative regulation of mitotic sister chromatid segregation (GO:0033048)2.65855264

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.77197940
2* MYC_18555785_ChIP-Seq_MESCs_Mouse3.99615428
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.59153114
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.58228240
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.23125749
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.22080863
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.03313611
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.96280388
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.92663087
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.75899422
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.67907911
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.65131098
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64937619
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.63275660
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59161957
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54445084
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.54170244
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52496716
19* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.49002856
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.45400082
21VDR_23849224_ChIP-Seq_CD4+_Human2.43289686
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36546360
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29461701
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25876913
25FOXM1_23109430_ChIP-Seq_U2OS_Human2.19345479
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.18033052
27FOXP3_21729870_ChIP-Seq_TREG_Human2.09358045
28ELK1_19687146_ChIP-ChIP_HELA_Human2.04864848
29* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.01819176
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98270966
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.97446616
32* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92629807
33* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87045215
34XRN2_22483619_ChIP-Seq_HELA_Human1.86927333
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.86352686
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78962597
37TTF2_22483619_ChIP-Seq_HELA_Human1.76064902
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76034201
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75859472
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.72574039
41DCP1A_22483619_ChIP-Seq_HELA_Human1.61646964
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60554265
43IRF1_19129219_ChIP-ChIP_H3396_Human1.60008978
44* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59488927
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57182075
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.55548427
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55353051
48* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53135643
49* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52441869
50* GABP_19822575_ChIP-Seq_HepG2_Human1.49823365
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.48773277
52* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45878317
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45352357
54* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44609694
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43887571
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40768612
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40151707
58* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39346031
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36758078
60AR_21909140_ChIP-Seq_LNCAP_Human1.36164698
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36018117
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.30645085
63MYC_18940864_ChIP-ChIP_HL60_Human1.30428161
64IRF8_22096565_ChIP-ChIP_GC-B_Human1.28308594
65* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.25430664
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21806308
67DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20342181
68* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18152781
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17364828
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.16167488
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15700428
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.14177542
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13326093
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13210130
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11622033
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10929108
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10774236
78* SPI1_23547873_ChIP-Seq_NB4_Human1.10742548
79TFEB_21752829_ChIP-Seq_HELA_Human1.09163529
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06131392
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03534194
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.00497103
83CHD1_26751641_Chip-Seq_LNCaP_Human1.00483342
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96833834
85SOX17_20123909_ChIP-Seq_XEN_Mouse0.95488672
86ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94387629
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92874107
88SALL1_21062744_ChIP-ChIP_HESCs_Human0.92624600
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92072559
90ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91489731
91CIITA_25753668_ChIP-Seq_RAJI_Human0.91046399
92TP63_19390658_ChIP-ChIP_HaCaT_Human0.90909547
93SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89572796
94POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89217263
95ELF5_23300383_ChIP-Seq_T47D_Human0.89090160
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88828874
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88483647
98EWS_26573619_Chip-Seq_HEK293_Human0.88185986
99KDM5A_27292631_Chip-Seq_BREAST_Human0.87943914
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87524904
101IGF1R_20145208_ChIP-Seq_DFB_Human0.87224096
102SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86211682
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85752906
104SOX2_16153702_ChIP-ChIP_HESCs_Human0.85689618
105* ELK1_22589737_ChIP-Seq_MCF10A_Human0.82939731
106NANOG_16153702_ChIP-ChIP_HESCs_Human0.82029069
107CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81888638
108FUS_26573619_Chip-Seq_HEK293_Human0.80975311
109FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.80074352
110ZNF274_21170338_ChIP-Seq_K562_Hela0.79951082
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.78989925
112EZH2_27294783_Chip-Seq_NPCs_Mouse0.78175747
113TP53_22573176_ChIP-Seq_HFKS_Human0.76377064
114* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76367599
115POU5F1_16153702_ChIP-ChIP_HESCs_Human0.74279392
116KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73811638
117NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.72807784
118GATA4_21415370_ChIP-Seq_HL-1_Mouse0.72633892
119ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.72269770
120CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.71933889
121MYB_26560356_Chip-Seq_TH1_Human0.69952865
122CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.69747841
123PKCTHETA_26484144_Chip-Seq_BREAST_Human0.68765237
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.68748716
125MYB_26560356_Chip-Seq_TH2_Human0.68725011
126SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.68531469
127SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.67977187
128CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.65735445
129STAT3_18555785_Chip-Seq_ESCs_Mouse0.65116529
130* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63834683

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.06405715
2MP0008057_abnormal_DNA_replication4.02195749
3MP0008058_abnormal_DNA_repair3.86707131
4MP0003693_abnormal_embryo_hatching3.68206315
5MP0003111_abnormal_nucleus_morphology3.10651975
6MP0003077_abnormal_cell_cycle2.76732512
7MP0004957_abnormal_blastocyst_morpholog2.76214785
8MP0003136_yellow_coat_color2.74218975
9MP0008877_abnormal_DNA_methylation2.69972403
10MP0008007_abnormal_cellular_replicative2.45279022
11MP0002396_abnormal_hematopoietic_system2.44493449
12MP0005410_abnormal_fertilization2.44050391
13MP0003763_abnormal_thymus_physiology2.32912412
14MP0001835_abnormal_antigen_presentation2.25024306
15MP0003786_premature_aging2.15687106
16MP0006292_abnormal_olfactory_placode2.05969145
17MP0005671_abnormal_response_to2.05673966
18MP0008932_abnormal_embryonic_tissue1.96574411
19MP0009379_abnormal_foot_pigmentation1.93261280
20MP0005174_abnormal_tail_pigmentation1.88899708
21MP0004381_abnormal_hair_follicle1.87250143
22MP0003806_abnormal_nucleotide_metabolis1.87194321
23MP0002132_abnormal_respiratory_system1.77725673
24MP0001986_abnormal_taste_sensitivity1.75118307
25MP0002210_abnormal_sex_determination1.72117975
26MP0005075_abnormal_melanosome_morpholog1.69986709
27MP0005409_darkened_coat_color1.69670101
28MP0002102_abnormal_ear_morphology1.69256322
29MP0001929_abnormal_gametogenesis1.69209478
30MP0000015_abnormal_ear_pigmentation1.65137207
31MP0005171_absent_coat_pigmentation1.64910179
32MP0000490_abnormal_crypts_of1.63834552
33MP0001188_hyperpigmentation1.59096543
34MP0002095_abnormal_skin_pigmentation1.53081165
35MP0001800_abnormal_humoral_immune1.46623803
36MP0006072_abnormal_retinal_apoptosis1.46397015
37MP0009785_altered_susceptibility_to1.45489977
38MP0002398_abnormal_bone_marrow1.44939288
39MP0003941_abnormal_skin_development1.44671535
40MP0000566_synostosis1.43851467
41MP0001145_abnormal_male_reproductive1.40284728
42MP0001853_heart_inflammation1.39971065
43MP0003698_abnormal_male_reproductive1.34869643
44MP0009333_abnormal_splenocyte_physiolog1.33523258
45MP0006036_abnormal_mitochondrial_physio1.33306864
46MP0002723_abnormal_immune_serum1.31385400
47MP0002148_abnormal_hypersensitivity_rea1.30175969
48MP0008789_abnormal_olfactory_epithelium1.29613695
49MP0002420_abnormal_adaptive_immunity1.28680507
50MP0002452_abnormal_antigen_presenting1.28677802
51MP0000689_abnormal_spleen_morphology1.28518494
52MP0002722_abnormal_immune_system1.28033515
53MP0000703_abnormal_thymus_morphology1.27939306
54MP0001819_abnormal_immune_cell1.27112568
55MP0005000_abnormal_immune_tolerance1.26760729
56MP0006035_abnormal_mitochondrial_morpho1.23630564
57MP0003724_increased_susceptibility_to1.22961460
58MP0005257_abnormal_intraocular_pressure1.22800748
59MP0000653_abnormal_sex_gland1.22359690
60MP0002277_abnormal_respiratory_mucosa1.21706512
61MP0003186_abnormal_redox_activity1.21531132
62MP0000716_abnormal_immune_system1.20914069
63MP0003718_maternal_effect1.17983773
64MP0001661_extended_life_span1.16888216
65MP0000313_abnormal_cell_death1.15955220
66MP0002405_respiratory_system_inflammati1.15738342
67MP0004233_abnormal_muscle_weight1.15380966
68MP0005025_abnormal_response_to1.14745140
69MP0002429_abnormal_blood_cell1.12650185
70MP0002084_abnormal_developmental_patter1.12067305
71MP0009697_abnormal_copulation1.11826282
72MP0000358_abnormal_cell_content/1.10753318
73MP0000350_abnormal_cell_proliferation1.10471072
74MP0000685_abnormal_immune_system1.09910762
75MP0000427_abnormal_hair_cycle1.08969381
76MP0004197_abnormal_fetal_growth/weight/1.08793964
77MP0003984_embryonic_growth_retardation1.08677299
78MP0002088_abnormal_embryonic_growth/wei1.07565049
79MP0002019_abnormal_tumor_incidence1.06598620
80MP0003787_abnormal_imprinting1.06365960
81MP0002160_abnormal_reproductive_system1.05375590
82MP0001286_abnormal_eye_development1.05031152
83MP0002837_dystrophic_cardiac_calcinosis1.03889961
84MP0002085_abnormal_embryonic_tissue1.02898126
85MP0004147_increased_porphyrin_level1.01371440
86MP0001919_abnormal_reproductive_system1.00884189
87MP0004808_abnormal_hematopoietic_stem1.00644833
88MP0008995_early_reproductive_senescence0.99177616
89MP0001873_stomach_inflammation0.98883505
90MP0000858_altered_metastatic_potential0.97427203
91MP0001293_anophthalmia0.96829985
92MP0001545_abnormal_hematopoietic_system0.95794780
93MP0005397_hematopoietic_system_phenotyp0.95794780
94MP0003315_abnormal_perineum_morphology0.94605206
95MP0001790_abnormal_immune_system0.94359536
96MP0005387_immune_system_phenotype0.94359536
97MP0003567_abnormal_fetal_cardiomyocyte0.93691706
98MP0002234_abnormal_pharynx_morphology0.92360042
99MP0000372_irregular_coat_pigmentation0.90697053
100MP0005253_abnormal_eye_physiology0.89089723
101MP0002163_abnormal_gland_morphology0.89069714
102MP0005187_abnormal_penis_morphology0.88438249
103MP0002938_white_spotting0.88057726
104MP0002233_abnormal_nose_morphology0.87960411
105MP0000428_abnormal_craniofacial_morphol0.86325955
106MP0003123_paternal_imprinting0.85580754
107MP0000465_gastrointestinal_hemorrhage0.85293936
108MP0002697_abnormal_eye_size0.84642678
109MP0001119_abnormal_female_reproductive0.84046960
110MP0000613_abnormal_salivary_gland0.83656745
111MP0001730_embryonic_growth_arrest0.82996968
112MP0005389_reproductive_system_phenotype0.82599826
113MP0002419_abnormal_innate_immunity0.81295067
114MP0005391_vision/eye_phenotype0.81010091
115MP0003121_genomic_imprinting0.80927365
116MP0002009_preneoplasia0.80265776
117MP0005379_endocrine/exocrine_gland_phen0.78347299
118MP0002638_abnormal_pupillary_reflex0.78057768
119MP0010155_abnormal_intestine_physiology0.77258638
120MP0005083_abnormal_biliary_tract0.75113200
121MP0005395_other_phenotype0.74511536
122MP0000631_abnormal_neuroendocrine_gland0.73368424
123MP0000516_abnormal_urinary_system0.73341830
124MP0005367_renal/urinary_system_phenotyp0.73341830
125MP0003755_abnormal_palate_morphology0.73172178
126MP0002086_abnormal_extraembryonic_tissu0.72718007
127MP0001944_abnormal_pancreas_morphology0.72717924
128MP0005499_abnormal_olfactory_system0.72544967
129MP0005394_taste/olfaction_phenotype0.72544967
130MP0010352_gastrointestinal_tract_polyps0.72405841
131MP0002161_abnormal_fertility/fecundity0.70800334
132MP0002092_abnormal_eye_morphology0.70216736
133MP0003656_abnormal_erythrocyte_physiolo0.69909475
134MP0004133_heterotaxia0.68559937
135MP0003646_muscle_fatigue0.68276330
136MP0009703_decreased_birth_body0.67936675
137MP0000647_abnormal_sebaceous_gland0.67724390
138MP0003937_abnormal_limbs/digits/tail_de0.67712732
139MP0001672_abnormal_embryogenesis/_devel0.67234474
140MP0005380_embryogenesis_phenotype0.67234474
141MP0002751_abnormal_autonomic_nervous0.67081431
142MP0005248_abnormal_Harderian_gland0.67051582
143MP0010307_abnormal_tumor_latency0.66882403
144MP0002006_tumorigenesis0.64423118
145MP0003890_abnormal_embryonic-extraembry0.63543359
146MP0005408_hypopigmentation0.62717200
147MP0002166_altered_tumor_susceptibility0.62336151
148MP0002080_prenatal_lethality0.61978856
149MP0001186_pigmentation_phenotype0.58217399
150MP0001845_abnormal_inflammatory_respons0.57376666
151MP0001697_abnormal_embryo_size0.57173079

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.39105192
2Chromsome breakage (HP:0040012)4.17837525
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.10198359
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.58602252
5Birth length less than 3rd percentile (HP:0003561)3.57351773
6Abnormality of cells of the erythroid lineage (HP:0012130)3.35913526
7Abnormal number of erythroid precursors (HP:0012131)3.20396650
8Duplicated collecting system (HP:0000081)3.06442385
9Abnormality of chromosome stability (HP:0003220)3.02538423
10Abnormality of the preputium (HP:0100587)3.00239914
1111 pairs of ribs (HP:0000878)2.99978522
12Acute encephalopathy (HP:0006846)2.98368847
13Abnormality of the renal collecting system (HP:0004742)2.96198102
14Acute necrotizing encephalopathy (HP:0006965)2.80977704
15Aplastic anemia (HP:0001915)2.75828733
16Pallor (HP:0000980)2.72150323
17Increased CSF lactate (HP:0002490)2.72094927
18Macrocytic anemia (HP:0001972)2.68010810
19Breast hypoplasia (HP:0003187)2.66316840
20Abnormality of DNA repair (HP:0003254)2.65878588
21Meckel diverticulum (HP:0002245)2.63948672
22Abnormal spermatogenesis (HP:0008669)2.55714716
233-Methylglutaconic aciduria (HP:0003535)2.54980075
24Mitochondrial inheritance (HP:0001427)2.53587930
25IgM deficiency (HP:0002850)2.50832754
26Abnormality of the ileum (HP:0001549)2.50374896
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.48814349
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.48814349
29Supernumerary spleens (HP:0009799)2.47238842
30Absent thumb (HP:0009777)2.46861796
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.46542971
32Absent/shortened dynein arms (HP:0200106)2.46542971
33Renal Fanconi syndrome (HP:0001994)2.46470436
34Progressive macrocephaly (HP:0004481)2.44678656
35Abnormal mitochondria in muscle tissue (HP:0008316)2.44238632
36Aplasia/Hypoplasia of the sacrum (HP:0008517)2.43523296
37Abnormality of methionine metabolism (HP:0010901)2.42841025
38Premature graying of hair (HP:0002216)2.42757755
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.41917988
40Hyperinsulinemic hypoglycemia (HP:0000825)2.40030032
41Abnormal lung lobation (HP:0002101)2.37313988
42Abnormal respiratory motile cilium physiology (HP:0012261)2.34947926
43Abnormal ciliary motility (HP:0012262)2.34555315
44Type I transferrin isoform profile (HP:0003642)2.34166446
45Hypoplasia of the fovea (HP:0007750)2.33886279
46Aplasia/Hypoplasia of the fovea (HP:0008060)2.33886279
47Oral leukoplakia (HP:0002745)2.32830772
48Abnormal respiratory motile cilium morphology (HP:0005938)2.31969326
49Abnormal respiratory epithelium morphology (HP:0012253)2.31969326
50IgG deficiency (HP:0004315)2.31187861
51Homocystinuria (HP:0002156)2.30982679
52Abnormality of homocysteine metabolism (HP:0010919)2.30982679
53Pancytopenia (HP:0001876)2.29954045
54Asplenia (HP:0001746)2.28621233
55Volvulus (HP:0002580)2.25900061
56Recurrent bronchitis (HP:0002837)2.25220958
57Hepatic necrosis (HP:0002605)2.24279922
58Megaloblastic anemia (HP:0001889)2.21478768
59Abnormality of the pons (HP:0007361)2.21353760
60Recurrent sinusitis (HP:0011108)2.20895239
61Median cleft lip (HP:0000161)2.19545460
62Myelodysplasia (HP:0002863)2.18865948
63Bone marrow hypocellularity (HP:0005528)2.18488388
64Hypoglycemic coma (HP:0001325)2.18248766
65Cerebral edema (HP:0002181)2.17149437
66Hepatocellular necrosis (HP:0001404)2.17132391
67Abnormality of the fovea (HP:0000493)2.16231719
68Clubbing of toes (HP:0100760)2.15956051
69Hypoplasia of the pons (HP:0012110)2.14248604
70Rib fusion (HP:0000902)2.14120055
71Increased hepatocellular lipid droplets (HP:0006565)2.13678646
72Ectopic kidney (HP:0000086)2.11615248
73Reduced antithrombin III activity (HP:0001976)2.08813842
74Microvesicular hepatic steatosis (HP:0001414)2.07820304
75Small intestinal stenosis (HP:0012848)2.06609064
76Duodenal stenosis (HP:0100867)2.06609064
77Aplasia/Hypoplasia of the spleen (HP:0010451)2.05484872
78Sloping forehead (HP:0000340)2.04028392
79Triphalangeal thumb (HP:0001199)2.02011834
80Abnormality of the carotid arteries (HP:0005344)1.99987251
81Lymphoma (HP:0002665)1.98351636
82Cleft eyelid (HP:0000625)1.97965380
83Severe combined immunodeficiency (HP:0004430)1.97655456
84Rough bone trabeculation (HP:0100670)1.97593399
85Overlapping toe (HP:0001845)1.96178390
86Abnormality of the labia minora (HP:0012880)1.95972397
87Abnormality of the anterior horn cell (HP:0006802)1.95698795
88Degeneration of anterior horn cells (HP:0002398)1.95698795
89Agnosia (HP:0010524)1.95335819
90Facial cleft (HP:0002006)1.94928138
91Hypoplasia of the radius (HP:0002984)1.93804528
92Sensory axonal neuropathy (HP:0003390)1.91966499
93Abnormality of secondary sexual hair (HP:0009888)1.91914361
94Abnormality of the axillary hair (HP:0100134)1.91914361
95Patellar aplasia (HP:0006443)1.91493894
96Progressive external ophthalmoplegia (HP:0000590)1.91481882
97Rhinitis (HP:0012384)1.91184527
98Hyperglycinemia (HP:0002154)1.89665370
99Selective tooth agenesis (HP:0001592)1.89496390
100Abnormality of glycolysis (HP:0004366)1.88503295
101Absent radius (HP:0003974)1.88116395
102Colon cancer (HP:0003003)1.87991817
103Methylmalonic acidemia (HP:0002912)1.87427965
104Testicular atrophy (HP:0000029)1.86925847
105Pancreatic fibrosis (HP:0100732)1.86294445
106Increased serum lactate (HP:0002151)1.86036068
107True hermaphroditism (HP:0010459)1.85000486
108Dyschromatopsia (HP:0007641)1.84926486
109Cerebral hypomyelination (HP:0006808)1.84747002
110Impulsivity (HP:0100710)1.84486817
111Horseshoe kidney (HP:0000085)1.84268168
112Abnormality of the heme biosynthetic pathway (HP:0010472)1.83568422
113Abnormality of B cell number (HP:0010975)1.83314535
114B lymphocytopenia (HP:0010976)1.83314535
115Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81661893
116Nephroblastoma (Wilms tumor) (HP:0002667)1.81512556
117Thrombocytosis (HP:0001894)1.80588089
118Abnormality of serum amino acid levels (HP:0003112)1.80330406
119Lactic acidosis (HP:0003128)1.80302890
120Type 2 muscle fiber atrophy (HP:0003554)1.78946623
121Nephronophthisis (HP:0000090)1.77819538
122Aplasia/Hypoplasia of the patella (HP:0006498)1.77380103
123Bronchiectasis (HP:0002110)1.77328189
124Squamous cell carcinoma (HP:0002860)1.76052816
125Bronchitis (HP:0012387)1.75829816
126Preaxial hand polydactyly (HP:0001177)1.75577798
127Ketoacidosis (HP:0001993)1.75048016
128Abnormal number of incisors (HP:0011064)1.74897610
129Lipid accumulation in hepatocytes (HP:0006561)1.74208878
130Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.73899804
131Abnormality of the intrinsic pathway (HP:0010989)1.73772829
132Agammaglobulinemia (HP:0004432)1.73132412
133Increased serum pyruvate (HP:0003542)1.73073213
134Aplasia involving forearm bones (HP:0009822)1.72949555
135Absent forearm bone (HP:0003953)1.72949555
136Septo-optic dysplasia (HP:0100842)1.72830828
137Optic nerve coloboma (HP:0000588)1.72714333
138Pancreatic cysts (HP:0001737)1.72089128
139Abnormality of the septum pellucidum (HP:0007375)1.71189104
140Abnormality of the duodenum (HP:0002246)1.70611983
141Abnormal protein glycosylation (HP:0012346)1.70173186
142Abnormal glycosylation (HP:0012345)1.70173186
143Abnormal protein N-linked glycosylation (HP:0012347)1.70173186
144Embryonal renal neoplasm (HP:0011794)1.69671804
145Amniotic constriction ring (HP:0009775)1.69278147
146Abnormality of placental membranes (HP:0011409)1.69278147
147Short thumb (HP:0009778)1.68612676
148Progressive muscle weakness (HP:0003323)1.68590083
149Facial hemangioma (HP:0000329)1.67793464
150Exercise intolerance (HP:0003546)1.67428186
151Abnormality of aspartate family amino acid metabolism (HP:0010899)1.66884189
152Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.66661957
153Increased nuchal translucency (HP:0010880)1.66229420

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.21831798
2WEE12.83061534
3EIF2AK12.80041711
4BUB12.74765966
5SRPK12.68084228
6CDC72.65539865
7ACVR1B2.52645241
8VRK22.47272903
9VRK12.26275936
10NEK12.16723489
11CASK2.09938891
12TLK12.04870912
13NME22.04001111
14BMPR1B2.03563929
15PBK1.96181139
16EIF2AK31.95295885
17MKNK21.91843770
18MKNK11.88813432
19BRSK21.85150405
20TSSK61.78398753
21IRAK41.77055592
22MST41.73532697
23TXK1.69988626
24TRIM281.67062510
25WNK41.66210203
26ZAK1.64505040
27FRK1.62554030
28PNCK1.62538358
29PLK41.61870210
30TTK1.61528721
31TGFBR11.55582287
32TAF11.46517723
33ATR1.44841701
34EIF2AK21.40175065
35PDK21.39307842
36MAP4K11.37593633
37CLK11.37569463
38PASK1.37009105
39MAP4K21.36762247
40CDK81.32882293
41RPS6KB21.30938831
42STK31.29984953
43TEC1.29661872
44BLK1.27028690
45IRAK31.26757357
46PLK11.22321942
47SIK31.20688200
48DYRK31.16046698
49NEK21.15693336
50CDK71.12029471
51SCYL21.10166862
52KIT1.09118692
53AURKB1.08330432
54CHEK21.04959902
55CCNB11.03318245
56PDK40.94987473
57PDK30.94987473
58YES10.94423641
59PLK30.91495303
60MAP3K140.88679142
61STK40.88372295
62NEK60.84082018
63PIM20.83184758
64INSRR0.82883374
65STK38L0.82391710
66JAK30.81277453
67CHEK10.79851336
68ATM0.78418107
69EPHA20.77727663
70STK100.77432380
71CDK120.77195061
72RPS6KA50.76129910
73LATS10.75617204
74NUAK10.75400353
75ADRBK20.73569121
76IKBKB0.73032194
77ERBB30.71932650
78GRK10.70738327
79RPS6KA40.70104515
80NME10.69434413
81CAMK1G0.69140536
82IRAK10.68372948
83PLK20.67304679
84CSNK2A20.66732535
85FLT30.66247060
86LYN0.66039134
87BTK0.66011024
88CSNK2A10.63936097
89KDR0.63473587
90IKBKE0.62151482
91EEF2K0.61416056
92CSNK1E0.61014123
93IRAK20.58194210
94PINK10.55679509
95PIM10.55588555
96NEK90.55239892
97LCK0.55223678
98OXSR10.53226207
99BRD40.53134774
100CDK190.52874396
101TNIK0.51839693
102SYK0.51356879
103CDK30.51145569
104AURKA0.50395330
105MAP3K120.50390581
106WNK10.50364209
107BCR0.50014787
108CAMK1D0.49912713
109WNK30.48367823
110CSF1R0.47174378
111MUSK0.46769151
112MAPK150.46349314
113RAF10.43820755
114TYK20.43513174
115ZAP700.43436560
116CSNK1G30.42922295
117CSNK1G10.41417307
118PRKDC0.40180572
119PRKCI0.40162201
120AKT30.40081817
121STK390.39312391
122AKT20.38536524
123MARK30.38445012
124MAPKAPK50.38437664
125CSNK1A1L0.38213425
126MELK0.38109924
127TESK20.38094700
128GRK70.38040233
129CDK20.37835156
130MAPK130.36977337
131CDK90.36723518
132DYRK20.36361140
133BRSK10.35504470
134KSR10.34942237
135CDK40.34770830
136ALK0.34614211
137RPS6KB10.32984937
138CDK10.32319517
139OBSCN0.30770140

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.99549969
2Ribosome_Homo sapiens_hsa030103.89150725
3Mismatch repair_Homo sapiens_hsa034303.62509231
4Proteasome_Homo sapiens_hsa030503.33832496
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.22519768
6Homologous recombination_Homo sapiens_hsa034403.22123088
7RNA polymerase_Homo sapiens_hsa030203.07565074
8Spliceosome_Homo sapiens_hsa030402.84628534
9Fanconi anemia pathway_Homo sapiens_hsa034602.78833787
10Nucleotide excision repair_Homo sapiens_hsa034202.70789088
11Base excision repair_Homo sapiens_hsa034102.65275661
12Non-homologous end-joining_Homo sapiens_hsa034502.54015957
13Basal transcription factors_Homo sapiens_hsa030222.41355516
14Pyrimidine metabolism_Homo sapiens_hsa002402.32160460
15RNA transport_Homo sapiens_hsa030132.26580925
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.04389338
17One carbon pool by folate_Homo sapiens_hsa006701.97795346
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95598189
19Cell cycle_Homo sapiens_hsa041101.84189127
20Primary immunodeficiency_Homo sapiens_hsa053401.80412163
21RNA degradation_Homo sapiens_hsa030181.78092145
22Pyruvate metabolism_Homo sapiens_hsa006201.56923038
23Protein export_Homo sapiens_hsa030601.55029174
24Propanoate metabolism_Homo sapiens_hsa006401.52579909
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44292860
26Purine metabolism_Homo sapiens_hsa002301.37935853
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.34531777
28mRNA surveillance pathway_Homo sapiens_hsa030151.23749969
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23102075
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22162093
31Allograft rejection_Homo sapiens_hsa053301.22076901
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17775424
33p53 signaling pathway_Homo sapiens_hsa041151.16062835
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.14549276
35Systemic lupus erythematosus_Homo sapiens_hsa053221.12999537
36Herpes simplex infection_Homo sapiens_hsa051681.12025211
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10510039
38Antigen processing and presentation_Homo sapiens_hsa046121.10297583
39Epstein-Barr virus infection_Homo sapiens_hsa051691.06434372
40Huntingtons disease_Homo sapiens_hsa050161.02432469
41NF-kappa B signaling pathway_Homo sapiens_hsa040640.98453905
42Autoimmune thyroid disease_Homo sapiens_hsa053200.96998449
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96265009
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96163737
45Measles_Homo sapiens_hsa051620.96063830
46Hematopoietic cell lineage_Homo sapiens_hsa046400.94467596
47Graft-versus-host disease_Homo sapiens_hsa053320.93114668
48Fatty acid elongation_Homo sapiens_hsa000620.89571869
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88184807
50Oxidative phosphorylation_Homo sapiens_hsa001900.87465167
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86463605
52Carbon metabolism_Homo sapiens_hsa012000.86292532
53Biosynthesis of amino acids_Homo sapiens_hsa012300.85835426
54Butanoate metabolism_Homo sapiens_hsa006500.85508543
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85022892
56Parkinsons disease_Homo sapiens_hsa050120.83902359
57Lysine degradation_Homo sapiens_hsa003100.83841852
58Sulfur metabolism_Homo sapiens_hsa009200.82665528
59Asthma_Homo sapiens_hsa053100.76988468
60Sulfur relay system_Homo sapiens_hsa041220.76043445
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74462753
62Pentose phosphate pathway_Homo sapiens_hsa000300.72422068
63Arachidonic acid metabolism_Homo sapiens_hsa005900.71330974
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71198710
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69618914
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67197937
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65644182
68Viral carcinogenesis_Homo sapiens_hsa052030.63304155
69Other glycan degradation_Homo sapiens_hsa005110.63082815
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61784727
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60930281
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59325629
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58529047
74Circadian rhythm_Homo sapiens_hsa047100.58444894
75Folate biosynthesis_Homo sapiens_hsa007900.57677194
76Legionellosis_Homo sapiens_hsa051340.55505642
77Cardiac muscle contraction_Homo sapiens_hsa042600.54790456
78Glutathione metabolism_Homo sapiens_hsa004800.54564282
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54521182
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54354235
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53615660
82Hedgehog signaling pathway_Homo sapiens_hsa043400.53215590
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52495827
84Peroxisome_Homo sapiens_hsa041460.51073418
85Fatty acid metabolism_Homo sapiens_hsa012120.49902160
86Thyroid cancer_Homo sapiens_hsa052160.49876544
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49829773
88Linoleic acid metabolism_Homo sapiens_hsa005910.49680050
89Ether lipid metabolism_Homo sapiens_hsa005650.49533344
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47913631
91HTLV-I infection_Homo sapiens_hsa051660.47264616
92Nitrogen metabolism_Homo sapiens_hsa009100.46530296
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46387961
94TGF-beta signaling pathway_Homo sapiens_hsa043500.45611939
95Phototransduction_Homo sapiens_hsa047440.45339031
96Vitamin B6 metabolism_Homo sapiens_hsa007500.43494007
97Influenza A_Homo sapiens_hsa051640.41744729
98beta-Alanine metabolism_Homo sapiens_hsa004100.41696466
99Sphingolipid metabolism_Homo sapiens_hsa006000.40947768
100Type I diabetes mellitus_Homo sapiens_hsa049400.40892149
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.39583753
102Alzheimers disease_Homo sapiens_hsa050100.38915632
103Vitamin digestion and absorption_Homo sapiens_hsa049770.38627227
104Fatty acid degradation_Homo sapiens_hsa000710.38523216
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38031576
106T cell receptor signaling pathway_Homo sapiens_hsa046600.37784710
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.37622800
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36025744
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35413241
110Hippo signaling pathway_Homo sapiens_hsa043900.35115740
111Metabolic pathways_Homo sapiens_hsa011000.34800687
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34485033
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33609257
114Shigellosis_Homo sapiens_hsa051310.32635691
115Basal cell carcinoma_Homo sapiens_hsa052170.31691169
116Leishmaniasis_Homo sapiens_hsa051400.31281793
117Malaria_Homo sapiens_hsa051440.30737290
118Apoptosis_Homo sapiens_hsa042100.30204389
119Arginine biosynthesis_Homo sapiens_hsa002200.29729566
120Fructose and mannose metabolism_Homo sapiens_hsa000510.29407408
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28734052
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28524639
123Chemical carcinogenesis_Homo sapiens_hsa052040.26987169
124Arginine and proline metabolism_Homo sapiens_hsa003300.26883059
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.26530140
126Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25941586
127B cell receptor signaling pathway_Homo sapiens_hsa046620.25533778
128Selenocompound metabolism_Homo sapiens_hsa004500.24485532
129Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23953095
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.23894975
131Alcoholism_Homo sapiens_hsa050340.23741987
132Tryptophan metabolism_Homo sapiens_hsa003800.22996408
133Viral myocarditis_Homo sapiens_hsa054160.22212386
134Renin-angiotensin system_Homo sapiens_hsa046140.21757729
135Wnt signaling pathway_Homo sapiens_hsa043100.21217821
136Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20895816
137Oocyte meiosis_Homo sapiens_hsa041140.20863329
138Caffeine metabolism_Homo sapiens_hsa002320.20185526
139Hepatitis B_Homo sapiens_hsa051610.19846308
140N-Glycan biosynthesis_Homo sapiens_hsa005100.18930800
141Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18027666
142Steroid biosynthesis_Homo sapiens_hsa001000.17896749
143Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17731477
144Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16951432
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.16706150
146Retinol metabolism_Homo sapiens_hsa008300.15548000

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