THY1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.40263138
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.20395931
3locomotory exploration behavior (GO:0035641)5.88812189
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.49956523
5synaptic vesicle exocytosis (GO:0016079)5.32625812
6glutamate secretion (GO:0014047)5.31417869
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.24593231
8vocalization behavior (GO:0071625)5.16627909
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.04850541
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.98248814
11regulation of synaptic vesicle exocytosis (GO:2000300)4.89112953
12regulation of glutamate receptor signaling pathway (GO:1900449)4.77273566
13neuronal action potential propagation (GO:0019227)4.58806118
14regulation of long-term neuronal synaptic plasticity (GO:0048169)4.52015493
15regulation of neuronal synaptic plasticity (GO:0048168)4.49309905
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.46484984
17neurotransmitter secretion (GO:0007269)4.45331041
18exploration behavior (GO:0035640)4.43064410
19regulation of synaptic vesicle transport (GO:1902803)4.36209482
20sodium ion export (GO:0071436)4.33956680
21protein localization to synapse (GO:0035418)4.32509336
22cellular potassium ion homeostasis (GO:0030007)4.22957451
23protein heterotrimerization (GO:0070208)4.17160428
24cerebellar granule cell differentiation (GO:0021707)4.04822721
25long-term memory (GO:0007616)3.98409906
26layer formation in cerebral cortex (GO:0021819)3.97246976
27regulation of synapse structural plasticity (GO:0051823)3.88324558
28synaptic transmission, glutamatergic (GO:0035249)3.84914582
29dendritic spine morphogenesis (GO:0060997)3.82078769
30glutamate receptor signaling pathway (GO:0007215)3.81968199
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.81250101
32amino acid import (GO:0043090)3.79334521
33proline transport (GO:0015824)3.79060383
34activation of protein kinase A activity (GO:0034199)3.75387048
35G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.70929409
36gamma-aminobutyric acid transport (GO:0015812)3.68628941
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.67579554
38neuron-neuron synaptic transmission (GO:0007270)3.64877272
39regulation of synaptic plasticity (GO:0048167)3.64272384
40negative regulation of cell killing (GO:0031342)3.63949764
41negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.63949764
42neuron cell-cell adhesion (GO:0007158)3.60934439
43positive regulation of membrane potential (GO:0045838)3.59354913
44cerebellar Purkinje cell differentiation (GO:0021702)3.59090867
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.48733558
46neurotransmitter transport (GO:0006836)3.47917073
47bone trabecula formation (GO:0060346)3.46287217
48neuromuscular process controlling balance (GO:0050885)3.45752363
49regulation of postsynaptic membrane potential (GO:0060078)3.44596001
50long-term synaptic potentiation (GO:0060291)3.42282552
51positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.42233595
52regulation of ARF protein signal transduction (GO:0032012)3.36375901
53regulation of dendritic spine morphogenesis (GO:0061001)3.35022073
54neurotransmitter-gated ion channel clustering (GO:0072578)3.35015547
55cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.32673857
56cerebellar Purkinje cell layer development (GO:0021680)3.28526700
57synaptic vesicle endocytosis (GO:0048488)3.27068915
58regulation of neurotransmitter levels (GO:0001505)3.26273017
59neuromuscular process controlling posture (GO:0050884)3.25354045
60positive regulation of synapse maturation (GO:0090129)3.24616956
61gamma-aminobutyric acid signaling pathway (GO:0007214)3.23884406
62collagen fibril organization (GO:0030199)3.20743629
63signal complex assembly (GO:0007172)3.20679947
64postsynaptic membrane organization (GO:0001941)3.19937542
65positive regulation of dendritic spine development (GO:0060999)3.19802035
66glycine transport (GO:0015816)3.19040110
67regulation of neurotransmitter secretion (GO:0046928)3.18455659
68positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.18217209
69vesicle transport along microtubule (GO:0047496)3.17657982
70cytoskeletal anchoring at plasma membrane (GO:0007016)3.17055186
71type B pancreatic cell proliferation (GO:0044342)3.16057070
72regulation of vesicle fusion (GO:0031338)3.13955400
73extracellular matrix assembly (GO:0085029)3.13791596
74negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.13324894
75positive regulation of fibroblast migration (GO:0010763)3.13105866
76cell communication by electrical coupling (GO:0010644)3.12085833
77negative regulation of dendrite morphogenesis (GO:0050774)3.11780223
78positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.08266936
79transmission of nerve impulse (GO:0019226)3.07506253
80regulation of clathrin-mediated endocytosis (GO:2000369)3.05551503
81neuronal ion channel clustering (GO:0045161)3.00255157
82neuron recognition (GO:0008038)3.00241840
83potassium ion homeostasis (GO:0055075)2.99943406
84negative regulation of synaptic transmission, GABAergic (GO:0032229)2.99880696
85positive regulation of neurotransmitter secretion (GO:0001956)2.98954153
86prepulse inhibition (GO:0060134)2.98071095
87regulation of synaptic transmission, glutamatergic (GO:0051966)2.97237656
88positive regulation of neurotransmitter transport (GO:0051590)2.96908853
89positive regulation of synaptic transmission, GABAergic (GO:0032230)2.95570600
90membrane depolarization (GO:0051899)2.95182930
91regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.93580993
92membrane depolarization during action potential (GO:0086010)2.92404855
93behavioral fear response (GO:0001662)2.92364743
94behavioral defense response (GO:0002209)2.92364743
95regulation of neurotransmitter transport (GO:0051588)2.92236081
96regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.91943926
97positive regulation of synaptic transmission (GO:0050806)2.89619660
98potassium ion import (GO:0010107)2.89471232
99dendritic spine organization (GO:0097061)2.88889355
100regulation of dendritic spine development (GO:0060998)2.88467784
101regulation of synaptic transmission (GO:0050804)2.87059721
102negative T cell selection (GO:0043383)2.86536968
103peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.85204415
104cellular sodium ion homeostasis (GO:0006883)2.85143296
105learning (GO:0007612)2.84988037
106innervation (GO:0060384)2.84654512
107response to gravity (GO:0009629)2.83726431
108chemosensory behavior (GO:0007635)2.83478232
109positive T cell selection (GO:0043368)2.82685552
110kidney mesenchyme development (GO:0072074)2.82664199
111social behavior (GO:0035176)2.82477608
112intraspecies interaction between organisms (GO:0051703)2.82477608
113L-amino acid import (GO:0043092)2.82395990
114response to histamine (GO:0034776)2.81139727
115neuromuscular process (GO:0050905)2.80016612
116synaptic transmission (GO:0007268)2.78589424
117axonal fasciculation (GO:0007413)2.78525650
118dermatan sulfate biosynthetic process (GO:0030208)2.76436541
119regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.75875830
120acidic amino acid transport (GO:0015800)2.73809978
121cell migration involved in heart development (GO:0060973)2.72630661
122positive regulation of dendritic spine morphogenesis (GO:0061003)2.68851038
123dermatan sulfate metabolic process (GO:0030205)2.67034386
124protein retention in ER lumen (GO:0006621)2.66805969
125regulation of voltage-gated calcium channel activity (GO:1901385)2.62836887
126vesicle docking involved in exocytosis (GO:0006904)2.58732482
127extracellular fibril organization (GO:0043206)2.58520504
128axon extension (GO:0048675)2.57643780
129chondrocyte proliferation (GO:0035988)2.57588816
130metanephric mesenchyme development (GO:0072075)2.55715854
131anatomical structure maturation (GO:0071695)2.55671759
132regulation of synapse maturation (GO:0090128)2.54460171
133protein targeting to plasma membrane (GO:0072661)2.53903749
134endodermal cell differentiation (GO:0035987)2.53657771
135sequestering of extracellular ligand from receptor (GO:0035581)2.51567045
136mating behavior (GO:0007617)2.51385119
137regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.51135581
138positive regulation of axon extension (GO:0045773)2.50228100

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.58768943
2* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.83593296
3RARB_27405468_Chip-Seq_BRAIN_Mouse3.08229285
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05712561
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01622099
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00860267
7DROSHA_22980978_ChIP-Seq_HELA_Human2.93571260
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79660734
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79660734
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.74496678
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.65736751
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58880931
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58285314
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57879143
15* REST_21632747_ChIP-Seq_MESCs_Mouse2.57588978
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50803054
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.49918515
18GBX2_23144817_ChIP-Seq_PC3_Human2.47370339
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.43275070
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41810650
21* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32989483
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20072970
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.18575405
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.16178613
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.11213111
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.10803634
27AR_21572438_ChIP-Seq_LNCaP_Human2.04318018
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.97925542
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.97371382
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.93453352
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.87649927
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81969489
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.77686813
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.71756964
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.63815500
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.63358104
37KDM2B_26808549_Chip-Seq_K562_Human1.59282509
38* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58197117
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56360550
40EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.54247098
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.49600672
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49304832
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44538580
44KDM2B_26808549_Chip-Seq_DND41_Human1.43544124
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42916176
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.41457513
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.41369159
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38592794
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.37715283
50GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37217269
51RING1B_27294783_Chip-Seq_ESCs_Mouse1.32397042
52ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31681647
53SMAD4_21799915_ChIP-Seq_A2780_Human1.31329513
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30147092
55KDM2B_26808549_Chip-Seq_JURKAT_Human1.28961847
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28938564
57TP53_20018659_ChIP-ChIP_R1E_Mouse1.28448051
58SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28424560
59* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28322273
60* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27076827
61* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25646547
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23482469
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22208025
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22048471
65OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.21794889
66AR_19668381_ChIP-Seq_PC3_Human1.20922403
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20256825
68* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20164024
69TP53_23651856_ChIP-Seq_MEFs_Mouse1.17476914
70CLOCK_20551151_ChIP-Seq_293T_Human1.16426739
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15732000
72SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14996370
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.14923306
74DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11201256
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11022012
76SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08505611
77RUNX_20019798_ChIP-Seq_JUKART_Human1.08386516
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07863445
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.07305048
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06510593
81TP53_16413492_ChIP-PET_HCT116_Human1.05228286
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04755419
83* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04580552
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.04355213
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04156295
86* LXR_22292898_ChIP-Seq_THP-1_Human1.03073964
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.02119751
88AR_25329375_ChIP-Seq_VCAP_Human1.01248562
89SA1_22415368_ChIP-Seq_MEFs_Mouse1.00482456
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00457581
91GATA1_26923725_Chip-Seq_HPCs_Mouse1.00422897
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99170650
93SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98125979
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97965739
95TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.97545412
96NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97122448
97* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96822421
98* RXR_22108803_ChIP-Seq_LS180_Human0.96207857
99PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95737238
100* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94203241
101ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93658970
102SMAD4_21741376_ChIP-Seq_HESCs_Human0.92976685
103SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92698047
104CTCF_27219007_Chip-Seq_Bcells_Human0.92446866
105STAT3_23295773_ChIP-Seq_U87_Human0.92184186
106TP53_18474530_ChIP-ChIP_U2OS_Human0.90704651
107TAF15_26573619_Chip-Seq_HEK293_Human0.90232795
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90226010
109* TET1_21490601_ChIP-Seq_MESCs_Mouse0.90173702
110* BRD4_25478319_ChIP-Seq_HGPS_Human0.89191636
111YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89048395
112RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88538636
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.88317488
114ZNF274_21170338_ChIP-Seq_K562_Hela0.87862601
115NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87427469
116* ISL1_27105846_Chip-Seq_CPCs_Mouse0.87388578
117SMAD3_21741376_ChIP-Seq_ESCs_Human0.87248777
118AHR_22903824_ChIP-Seq_MCF-7_Human0.87027228
119ARNT_22903824_ChIP-Seq_MCF-7_Human0.85915401
120SMC4_20622854_ChIP-Seq_HELA_Human0.85764001
121CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85120417
122TP53_22127205_ChIP-Seq_IMR90_Human0.84343245
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84026437
124ELK3_25401928_ChIP-Seq_HUVEC_Human0.83373134
125RAD21_21589869_ChIP-Seq_MESCs_Mouse0.82765226
126SMAD3_21741376_ChIP-Seq_EPCs_Human0.82582502
127CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.81982209
128TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.81953640
129KLF4_19829295_ChIP-Seq_ESCs_Human0.81875482
130TCF4_23295773_ChIP-Seq_U87_Human0.81522914
131TCF7_22412390_ChIP-Seq_EML_Mouse0.81097080
132ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80544602
133TOP2B_26459242_ChIP-Seq_MCF-7_Human0.79928744
134TRIM28_21343339_ChIP-Seq_HEK293_Human0.79865587
135NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.79371544
136NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78190615
137NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77895786
138* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.77868162
139TBX3_20139965_ChIP-Seq_MESCs_Mouse0.77366835
140MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.77306683
141EGR1_19032775_ChIP-ChIP_M12_Human0.76394258
142TBX3_20139965_ChIP-Seq_ESCs_Mouse0.76311313

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.61714612
2MP0008438_abnormal_cutaneous_collagen5.51905748
3MP0003880_abnormal_central_pattern4.71244186
4* MP0003635_abnormal_synaptic_transmissio4.44203944
5MP0005503_abnormal_tendon_morphology3.55909766
6MP0009745_abnormal_behavioral_response3.54558520
7MP0004270_analgesia3.49509809
8MP0003705_abnormal_hypodermis_morpholog3.47851892
9MP0002063_abnormal_learning/memory/cond3.44460916
10MP0002064_seizures3.31104076
11MP0002822_catalepsy3.06207714
12MP0001968_abnormal_touch/_nociception2.99662902
13MP0001958_emphysema2.92089191
14MP0009046_muscle_twitch2.87400766
15MP0003279_aneurysm2.85437569
16MP0002572_abnormal_emotion/affect_behav2.74069487
17MP0005275_abnormal_skin_tensile2.64891865
18MP0002272_abnormal_nervous_system2.54881359
19MP0005423_abnormal_somatic_nervous2.52306146
20MP0001501_abnormal_sleep_pattern2.50986847
21MP0004272_abnormal_basement_membrane2.42093104
22MP0008569_lethality_at_weaning2.39960510
23MP0001486_abnormal_startle_reflex2.39186831
24MP0002734_abnormal_mechanical_nocicepti2.27423568
25MP0002736_abnormal_nociception_after2.25886523
26MP0003329_amyloid_beta_deposits2.18067597
27MP0002735_abnormal_chemical_nociception2.10247721
28MP0004858_abnormal_nervous_system2.03636795
29MP0009780_abnormal_chondrocyte_physiolo2.01240255
30MP0001542_abnormal_bone_strength1.98582106
31MP0001440_abnormal_grooming_behavior1.92975217
32MP0005257_abnormal_intraocular_pressure1.92167041
33MP0001970_abnormal_pain_threshold1.91374750
34MP0002733_abnormal_thermal_nociception1.87098078
35MP0004811_abnormal_neuron_physiology1.84280625
36MP0002067_abnormal_sensory_capabilities1.78450167
37MP0009384_cardiac_valve_regurgitation1.76432574
38MP0002909_abnormal_adrenal_gland1.64636703
39MP0002295_abnormal_pulmonary_circulatio1.64578496
40MP0002184_abnormal_innervation1.62049594
41MP0003879_abnormal_hair_cell1.59572213
42MP0004924_abnormal_behavior1.57664461
43MP0005386_behavior/neurological_phenoty1.57664461
44MP0006054_spinal_hemorrhage1.55325564
45MP0002557_abnormal_social/conspecific_i1.55285976
46MP0003787_abnormal_imprinting1.52820692
47MP0005508_abnormal_skeleton_morphology1.44566952
48MP0003633_abnormal_nervous_system1.43990277
49MP0008961_abnormal_basal_metabolism1.40642658
50MP0000955_abnormal_spinal_cord1.39055793
51MP0003566_abnormal_cell_adhesion1.36729196
52MP0002066_abnormal_motor_capabilities/c1.35613182
53MP0005623_abnormal_meninges_morphology1.34115263
54MP0000013_abnormal_adipose_tissue1.30688050
55MP0010368_abnormal_lymphatic_system1.26465457
56MP0004510_myositis1.26404447
57MP0000778_abnormal_nervous_system1.24522908
58MP0003941_abnormal_skin_development1.24479047
59MP0002882_abnormal_neuron_morphology1.24274147
60MP0004885_abnormal_endolymph1.20213257
61MP0006276_abnormal_autonomic_nervous1.19792736
62MP0002254_reproductive_system_inflammat1.18214603
63MP0001502_abnormal_circadian_rhythm1.17027411
64MP0008874_decreased_physiological_sensi1.15538909
65MP0003631_nervous_system_phenotype1.13474178
66MP0003075_altered_response_to1.12970118
67MP0000767_abnormal_smooth_muscle1.10823320
68MP0000534_abnormal_ureter_morphology1.10476873
69MP0005595_abnormal_vascular_smooth1.08525311
70MP0000604_amyloidosis1.03488877
71MP0002108_abnormal_muscle_morphology1.01539379
72MP0000920_abnormal_myelination1.00327113
73MP0005409_darkened_coat_color1.00324987
74MP0003091_abnormal_cell_migration0.99814505
75MP0005646_abnormal_pituitary_gland0.99784823
76MP0004142_abnormal_muscle_tone0.99561278
77MP0008872_abnormal_physiological_respon0.99051861
78MP0001905_abnormal_dopamine_level0.98473939
79MP0000751_myopathy0.96358930
80MP0009250_abnormal_appendicular_skeleto0.95448295
81MP0001984_abnormal_olfaction0.94889191
82MP0002152_abnormal_brain_morphology0.94815472
83MP0003122_maternal_imprinting0.91699794
84MP0001177_atelectasis0.88593893
85MP0002069_abnormal_eating/drinking_beha0.87605051
86MP0005645_abnormal_hypothalamus_physiol0.86434958
87MP0003045_fibrosis0.86362129
88MP0002896_abnormal_bone_mineralization0.86072476
89MP0010234_abnormal_vibrissa_follicle0.85691096
90MP0002133_abnormal_respiratory_system0.84644546
91MP0005388_respiratory_system_phenotype0.84644546
92MP0001849_ear_inflammation0.83869533
93MP0005023_abnormal_wound_healing0.83849357
94MP0002060_abnormal_skin_morphology0.82974210
95MP0001529_abnormal_vocalization0.82395047
96MP0003942_abnormal_urinary_system0.82313703
97MP0003385_abnormal_body_wall0.81862987
98MP0001348_abnormal_lacrimal_gland0.81485866
99MP0000049_abnormal_middle_ear0.80678402
100MP0003763_abnormal_thymus_physiology0.80158800
101MP0000569_abnormal_digit_pigmentation0.78587110
102MP0005535_abnormal_body_temperature0.77321641
103MP0001243_abnormal_dermal_layer0.76543189
104MP0010030_abnormal_orbit_morphology0.76052139
105MP0003172_abnormal_lysosome_physiology0.73875861
106MP0003283_abnormal_digestive_organ0.73442737
107MP0000428_abnormal_craniofacial_morphol0.72209047
108MP0004145_abnormal_muscle_electrophysio0.72080480
109MP0002089_abnormal_postnatal_growth/wei0.71310679
110MP0004484_altered_response_of0.71256833
111MP0003634_abnormal_glial_cell0.70259776
112MP0002229_neurodegeneration0.68703001
113MP0004742_abnormal_vestibular_system0.67403311
114MP0000462_abnormal_digestive_system0.66204706
115MP0000703_abnormal_thymus_morphology0.65857750
116MP0003632_abnormal_nervous_system0.63702683
117MP0002837_dystrophic_cardiac_calcinosis0.63651500
118MP0003690_abnormal_glial_cell0.61884751
119MP0004085_abnormal_heartbeat0.61049920
120MP0005166_decreased_susceptibility_to0.59503749
121MP0002249_abnormal_larynx_morphology0.59118124
122MP0000749_muscle_degeneration0.58896991
123MP0004130_abnormal_muscle_cell0.58761526
124MP0000759_abnormal_skeletal_muscle0.58191162
125MP0008770_decreased_survivor_rate0.57692562
126MP0001299_abnormal_eye_distance/0.56829450
127MP0000747_muscle_weakness0.56651606
128MP0002090_abnormal_vision0.56541123
129MP0010769_abnormal_survival0.55618390
130MP0005390_skeleton_phenotype0.55332882
131MP0003300_gastrointestinal_ulcer0.53299849
132MP0001943_abnormal_respiration0.52043172
133MP0010768_mortality/aging0.51302889
134MP0000003_abnormal_adipose_tissue0.51280191
135MP0004233_abnormal_muscle_weight0.50606256
136MP0010386_abnormal_urinary_bladder0.49734872
137MP0005394_taste/olfaction_phenotype0.49572499
138MP0005499_abnormal_olfactory_system0.49572499
139MP0003956_abnormal_body_size0.48911319
140MP0005167_abnormal_blood-brain_barrier0.48740726

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.13274942
2Myokymia (HP:0002411)6.66884827
3Premature rupture of membranes (HP:0001788)6.40027745
4Focal seizures (HP:0007359)5.55429134
5Visual hallucinations (HP:0002367)5.21310626
6Atonic seizures (HP:0010819)4.65866157
7Ankle contracture (HP:0006466)4.32209725
8Absence seizures (HP:0002121)4.01041448
9Broad metatarsal (HP:0001783)4.00197453
10Febrile seizures (HP:0002373)3.98381106
11Vascular tortuosity (HP:0004948)3.95309888
12Aortic aneurysm (HP:0004942)3.90803440
13Epileptic encephalopathy (HP:0200134)3.89380110
14Progressive cerebellar ataxia (HP:0002073)3.87497299
15Shallow orbits (HP:0000586)3.86351372
16Action tremor (HP:0002345)3.81895455
17Bladder diverticulum (HP:0000015)3.76922068
18Supranuclear gaze palsy (HP:0000605)3.74445091
19Aortic dissection (HP:0002647)3.67719737
20Type 1 muscle fiber predominance (HP:0003803)3.62245628
21Soft skin (HP:0000977)3.54229676
22Dialeptic seizures (HP:0011146)3.51948088
23Abnormality of dentin (HP:0010299)3.49051411
24Follicular hyperkeratosis (HP:0007502)3.45032102
25Generalized tonic-clonic seizures (HP:0002069)3.39438005
26Slender build (HP:0001533)3.39348404
27Impaired vibration sensation in the lower limbs (HP:0002166)3.33657572
28Arterial tortuosity (HP:0005116)3.24542458
29Depression (HP:0000716)3.20785912
30Spinal rigidity (HP:0003306)3.18114319
31Papilledema (HP:0001085)3.17001413
32Hemiplegia (HP:0002301)3.16527344
33Wormian bones (HP:0002645)3.13503090
34Neonatal short-limb short stature (HP:0008921)3.13413395
35Truncal ataxia (HP:0002078)3.07251676
36Ankle clonus (HP:0011448)3.05853700
37Poor eye contact (HP:0000817)2.99895618
38Dysmetria (HP:0001310)2.99420921
39Abnormal social behavior (HP:0012433)2.96302023
40Impaired social interactions (HP:0000735)2.96302023
41Atrophic scars (HP:0001075)2.96150736
42T lymphocytopenia (HP:0005403)2.91724915
43Urinary bladder sphincter dysfunction (HP:0002839)2.91595340
44Dysdiadochokinesis (HP:0002075)2.84673754
45Urinary urgency (HP:0000012)2.83971467
46Annular pancreas (HP:0001734)2.83634447
47Impaired smooth pursuit (HP:0007772)2.81966587
48Broad-based gait (HP:0002136)2.80163985
49Gaze-evoked nystagmus (HP:0000640)2.79732814
50Fragile skin (HP:0001030)2.77307405
51Mild short stature (HP:0003502)2.76205220
52Diplopia (HP:0000651)2.75516182
53Abnormality of binocular vision (HP:0011514)2.75516182
54Genetic anticipation (HP:0003743)2.73083686
55Abnormality of T cell number (HP:0011839)2.71158099
56Anxiety (HP:0000739)2.71152847
57Abnormality of the lower motor neuron (HP:0002366)2.70358556
58Dysmetric saccades (HP:0000641)2.69741736
59Amblyopia (HP:0000646)2.69416569
60Abnormal eating behavior (HP:0100738)2.65151010
61Increased variability in muscle fiber diameter (HP:0003557)2.64166850
62Coronal craniosynostosis (HP:0004440)2.62897966
63Postural instability (HP:0002172)2.60239008
64Pointed chin (HP:0000307)2.58720931
65Turricephaly (HP:0000262)2.53562205
66Upper limb amyotrophy (HP:0009129)2.53280275
67Distal upper limb amyotrophy (HP:0007149)2.53280275
68Overgrowth (HP:0001548)2.50201103
69Cerebral inclusion bodies (HP:0100314)2.46322403
70Stereotypic behavior (HP:0000733)2.46073986
71Ventricular fibrillation (HP:0001663)2.45960789
72Hyperextensible skin (HP:0000974)2.45421115
73Insomnia (HP:0100785)2.44520988
74Biconcave vertebral bodies (HP:0004586)2.44313940
75Abnormality of ocular smooth pursuit (HP:0000617)2.42696670
76Blue sclerae (HP:0000592)2.36599670
77Cerebral aneurysm (HP:0004944)2.34762228
78Spastic gait (HP:0002064)2.32419899
79Vertebral compression fractures (HP:0002953)2.30016341
80Hand muscle atrophy (HP:0009130)2.28517279
81Mitral regurgitation (HP:0001653)2.27969789
82Mutism (HP:0002300)2.27314031
83Torticollis (HP:0000473)2.27265201
84Megalencephaly (HP:0001355)2.26288882
85Scanning speech (HP:0002168)2.24667880
86Hypercortisolism (HP:0001578)2.24604113
87Mildly elevated creatine phosphokinase (HP:0008180)2.24144427
88Cervical subluxation (HP:0003308)2.23029655
89Spinal canal stenosis (HP:0003416)2.20342631
90Intention tremor (HP:0002080)2.18104035
91Insidious onset (HP:0003587)2.17686296
92Termporal pattern (HP:0011008)2.17686296
93Neurofibrillary tangles (HP:0002185)2.17062066
94Abnormality of oral frenula (HP:0000190)2.16423780
95Ankyloglossia (HP:0010296)2.16281659
96Mitral valve prolapse (HP:0001634)2.15528943
97Abnormality of skeletal muscle fiber size (HP:0012084)2.14168870
98Lower limb amyotrophy (HP:0007210)2.13893271
99Focal dystonia (HP:0004373)2.13433130
100Bradykinesia (HP:0002067)2.12554539
101Progressive inability to walk (HP:0002505)2.12130773
102Achilles tendon contracture (HP:0001771)2.09222715
103Impaired vibratory sensation (HP:0002495)2.09064251
104Joint laxity (HP:0001388)2.08931080
105Hyperventilation (HP:0002883)2.08896069
106Wrist flexion contracture (HP:0001239)2.07905562
107Status epilepticus (HP:0002133)2.06810183
108Abnormality of B cell number (HP:0010975)2.01941597
109B lymphocytopenia (HP:0010976)2.01941597
110Lower limb asymmetry (HP:0100559)2.00926829
111Rapidly progressive (HP:0003678)2.00793525
112Macroorchidism (HP:0000053)2.00224902
113Aortic regurgitation (HP:0001659)1.98271004
114Peritonitis (HP:0002586)1.98216290
115Obstructive sleep apnea (HP:0002870)1.97805226
116Hyperacusis (HP:0010780)1.96999260
117Wide anterior fontanel (HP:0000260)1.96464154
118Renal duplication (HP:0000075)1.96389709
119Hypoventilation (HP:0002791)1.95634149
120Hemiparesis (HP:0001269)1.95560095
121Drooling (HP:0002307)1.95146178
122Excessive salivation (HP:0003781)1.95146178
123Bundle branch block (HP:0011710)1.94881448
124Ulnar bowing (HP:0003031)1.93462450
125Panhypogammaglobulinemia (HP:0003139)1.91644346
126Protrusio acetabuli (HP:0003179)1.90078464
127Abnormality of saccadic eye movements (HP:0000570)1.89071679
128Deep palmar crease (HP:0006191)1.87906752
129Abnormal delivery (HP:0001787)1.87166720
130Dilatation of the ascending aorta (HP:0005111)1.86841076
131Narrow nasal bridge (HP:0000446)1.84699931
132Neuronal loss in central nervous system (HP:0002529)1.84540434
133Sleep apnea (HP:0010535)1.84290773
134Limb-girdle muscle weakness (HP:0003325)1.82480326
135Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82370784
136Craniofacial dystonia (HP:0012179)1.81280308
137Flat cornea (HP:0007720)1.81010880
138Bowel diverticulosis (HP:0005222)1.80367485
139Lower limb muscle weakness (HP:0007340)1.79961138
140Aortic valve stenosis (HP:0001650)1.79836091
141Ectopia lentis (HP:0001083)1.79226410
142Abnormality of the Achilles tendon (HP:0005109)1.79035258
143Protruding ear (HP:0000411)1.78865520
144Amyotrophic lateral sclerosis (HP:0007354)1.76318302
145Generalized hypotonia (HP:0001290)1.76298685
146Deviation of the hallux (HP:0010051)1.76146720
147Generalized amyotrophy (HP:0003700)1.74781999
148Aplasia involving bones of the upper limbs (HP:0009823)1.74235014
149Aplasia of the phalanges of the hand (HP:0009802)1.74235014
150Aplasia involving bones of the extremities (HP:0009825)1.74235014
151Psychosis (HP:0000709)1.74097166
152Striae distensae (HP:0001065)1.74022594
153Gait ataxia (HP:0002066)1.72991819
154Genu recurvatum (HP:0002816)1.72211323
155Round ear (HP:0100830)1.72055966
156Spondylolisthesis (HP:0003302)1.71380903
157Aneurysm (HP:0002617)1.71221936
158Epileptiform EEG discharges (HP:0011182)1.71185558
159Elbow flexion contracture (HP:0002987)1.70682506
160Resting tremor (HP:0002322)1.70652717
161Generalized myoclonic seizures (HP:0002123)1.69737110
162Overriding aorta (HP:0002623)1.68429045

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.39060312
2EPHA44.01595679
3MAP3K93.68820063
4MYLK2.75604959
5MINK12.64156330
6MAP3K42.50655785
7KSR22.42926237
8PAK62.35041724
9CAMKK12.30799128
10DAPK22.28240432
11PRKD32.24797293
12LIMK12.18560708
13RIPK42.16308121
14TESK12.01843526
15NTRK21.94325764
16DDR21.90458516
17NTRK11.90177288
18SIK21.80199097
19MAP2K71.76560124
20MAP3K121.75003070
21PAK21.74826862
22MAP3K131.71707429
23STK381.68375977
24TYRO31.62846610
25PRKCH1.56219047
26MAP2K41.55090302
27PTK21.54873967
28FES1.51812207
29DAPK11.46889138
30CDK51.46685552
31KSR11.44906588
32TAOK11.44649998
33MARK11.42346921
34TRIB31.32019045
35TNK21.26908105
36PRPF4B1.24875174
37MAP3K71.24389806
38MAP3K21.21323024
39ARAF1.21303963
40ALK1.19682920
41GRK51.19568398
42PLK21.19243327
43CDK191.18633065
44CAMKK21.17687957
45TTN1.16617810
46RET1.16347308
47TXK1.14273139
48PRKCG1.10397154
49CAMK11.10286724
50PNCK1.10077985
51UHMK11.08665860
52CAMK2G1.02308402
53PKN21.02017603
54RAF11.01203886
55PRKG20.95738044
56PDK10.95145825
57STK110.95009202
58PTK2B0.93844668
59LATS20.93806261
60MARK20.92058013
61BRSK10.91219406
62DMPK0.89723409
63GRK60.87426051
64CDK150.87397162
65CDK180.86604291
66PAK30.84215782
67ROCK10.83891480
68CDK140.83508288
69MOS0.81316874
70LMTK20.79991580
71MAP3K10.79700414
72SGK30.79077099
73CDK11A0.77891722
74PDGFRA0.76647642
75CAMK2A0.72951562
76BRAF0.71422608
77PDPK10.70730625
78PDGFRB0.70211878
79TNIK0.69503660
80ABL20.69278114
81CASK0.68311183
82EPHB20.66193821
83RPS6KA20.63859310
84FYN0.63044187
85PAK40.62274809
86EEF2K0.61782361
87WNK10.60760835
88PINK10.58891010
89PRKCQ0.58599718
90CAMK2B0.58096020
91RIPK10.57456942
92MAPK130.57423510
93DAPK30.56908842
94SGK10.56860984
95CAMK1G0.56100488
96PRKD20.55734227
97SGK2230.54481767
98SGK4940.54481767
99PAK10.54163491
100CAMK2D0.53734430
101SCYL20.52364121
102ITK0.51793982
103MAPK70.51344952
104CDC42BPA0.51242732
105ADRBK10.50832393
106SYK0.49769002
107MAPK100.49745363
108ROCK20.48890720
109BMPR20.48671674
110NEK90.48152731
111BMX0.47905203
112FGFR20.47749932
113CAMK40.47544478
114HCK0.47392981
115SGK20.46893530
116CSNK1G20.45245730
117RPS6KA30.44293716
118MAP4K10.44168457
119JAK10.43686779
120NEK60.42199519
121AKT30.41745293
122ERBB40.39986885
123PRKCE0.39204244
124SRC0.37167119
125MAP3K110.36114004
126MAP2K10.35591537
127PKN10.35531924
128MAPK120.35344270
129PRKCB0.35089503
130FGFR30.35077999
131DYRK1A0.33721885
132NEK10.33680804
133TAOK20.32420559
134PHKG20.30465266
135PHKG10.30465266
136PLK30.29923955
137PRKD10.28449542
138PRKCA0.27349237
139SIK10.27274430

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.97930506
2Synaptic vesicle cycle_Homo sapiens_hsa047212.80117291
3Long-term potentiation_Homo sapiens_hsa047202.67107177
4Olfactory transduction_Homo sapiens_hsa047402.49911931
5Circadian entrainment_Homo sapiens_hsa047132.34084172
6Amphetamine addiction_Homo sapiens_hsa050312.27185904
7Glutamatergic synapse_Homo sapiens_hsa047242.25353631
8GABAergic synapse_Homo sapiens_hsa047272.24320453
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.21656377
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20606279
11Morphine addiction_Homo sapiens_hsa050322.13898573
12Salivary secretion_Homo sapiens_hsa049702.07693000
13Dopaminergic synapse_Homo sapiens_hsa047281.95638215
14Gastric acid secretion_Homo sapiens_hsa049711.94121925
15ECM-receptor interaction_Homo sapiens_hsa045121.93511074
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80593102
17Cholinergic synapse_Homo sapiens_hsa047251.80075299
18Insulin secretion_Homo sapiens_hsa049111.74089419
19Vitamin B6 metabolism_Homo sapiens_hsa007501.68224786
20Oxytocin signaling pathway_Homo sapiens_hsa049211.66581343
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65062629
22Renin secretion_Homo sapiens_hsa049241.56501169
23Long-term depression_Homo sapiens_hsa047301.52791588
24GnRH signaling pathway_Homo sapiens_hsa049121.48110857
25Focal adhesion_Homo sapiens_hsa045101.47014855
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46337323
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43313382
28Calcium signaling pathway_Homo sapiens_hsa040201.43125354
29Cocaine addiction_Homo sapiens_hsa050301.41930924
30Glioma_Homo sapiens_hsa052141.40507309
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34777660
32Protein digestion and absorption_Homo sapiens_hsa049741.34156532
33Taste transduction_Homo sapiens_hsa047421.34099741
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29275608
35Estrogen signaling pathway_Homo sapiens_hsa049151.28626450
36Gap junction_Homo sapiens_hsa045401.26343273
37T cell receptor signaling pathway_Homo sapiens_hsa046601.23568850
38Serotonergic synapse_Homo sapiens_hsa047261.22545251
39cAMP signaling pathway_Homo sapiens_hsa040241.20719387
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13416384
41ErbB signaling pathway_Homo sapiens_hsa040121.11364015
42Melanogenesis_Homo sapiens_hsa049161.09329450
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08361048
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06865216
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05678725
46Type II diabetes mellitus_Homo sapiens_hsa049301.04420915
47Dorso-ventral axis formation_Homo sapiens_hsa043201.03975955
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03390406
49Nitrogen metabolism_Homo sapiens_hsa009101.02071709
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.98383983
51VEGF signaling pathway_Homo sapiens_hsa043700.97755783
52Proteoglycans in cancer_Homo sapiens_hsa052050.97176539
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.93440133
54Hippo signaling pathway_Homo sapiens_hsa043900.90756021
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.90310188
56Axon guidance_Homo sapiens_hsa043600.89533594
57Collecting duct acid secretion_Homo sapiens_hsa049660.89069871
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88353579
59Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86702019
60Amoebiasis_Homo sapiens_hsa051460.86622498
61Choline metabolism in cancer_Homo sapiens_hsa052310.84886590
62Oocyte meiosis_Homo sapiens_hsa041140.84884900
63Primary immunodeficiency_Homo sapiens_hsa053400.83737696
64MAPK signaling pathway_Homo sapiens_hsa040100.82809035
65Non-small cell lung cancer_Homo sapiens_hsa052230.81027758
66Dilated cardiomyopathy_Homo sapiens_hsa054140.78077356
67Tight junction_Homo sapiens_hsa045300.77482323
68Thyroid hormone synthesis_Homo sapiens_hsa049180.77461611
69Pancreatic secretion_Homo sapiens_hsa049720.77035537
70Type I diabetes mellitus_Homo sapiens_hsa049400.76616930
71Rap1 signaling pathway_Homo sapiens_hsa040150.75558090
72mTOR signaling pathway_Homo sapiens_hsa041500.75149365
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74607031
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71516521
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71422008
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70788728
77Endocytosis_Homo sapiens_hsa041440.70500180
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69590322
79Endometrial cancer_Homo sapiens_hsa052130.69336958
80Chemokine signaling pathway_Homo sapiens_hsa040620.68391229
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68380818
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66239031
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65878043
84Adherens junction_Homo sapiens_hsa045200.65247264
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.63455919
86Ras signaling pathway_Homo sapiens_hsa040140.63069812
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62518292
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62511843
89Cardiac muscle contraction_Homo sapiens_hsa042600.61275813
90Melanoma_Homo sapiens_hsa052180.61120077
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.59441128
92Colorectal cancer_Homo sapiens_hsa052100.59416113
93Glucagon signaling pathway_Homo sapiens_hsa049220.56880486
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56684048
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56137059
96Platelet activation_Homo sapiens_hsa046110.56050488
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55868471
98Vibrio cholerae infection_Homo sapiens_hsa051100.55153793
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55132915
100Hedgehog signaling pathway_Homo sapiens_hsa043400.54391717
101Renal cell carcinoma_Homo sapiens_hsa052110.53935516
102Inositol phosphate metabolism_Homo sapiens_hsa005620.52585941
103Wnt signaling pathway_Homo sapiens_hsa043100.51127701
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50141738
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.47884127
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47726547
107Chronic myeloid leukemia_Homo sapiens_hsa052200.46858735
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46083099
109Insulin signaling pathway_Homo sapiens_hsa049100.45931568
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45546207
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45199636
112Basal cell carcinoma_Homo sapiens_hsa052170.44816223
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44115771
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43803980
115Bile secretion_Homo sapiens_hsa049760.43319222
116Prolactin signaling pathway_Homo sapiens_hsa049170.42438989
117Prion diseases_Homo sapiens_hsa050200.41056225
118Phototransduction_Homo sapiens_hsa047440.38776255
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37744779
120MicroRNAs in cancer_Homo sapiens_hsa052060.37518183
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33233590
122Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32635596
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32247552
124Pathways in cancer_Homo sapiens_hsa052000.31788635
125Bladder cancer_Homo sapiens_hsa052190.29651524

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