TIA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.62850341
2neural tube formation (GO:0001841)4.84397789
3nucleobase catabolic process (GO:0046113)4.33493017
4neuron cell-cell adhesion (GO:0007158)4.22709231
5presynaptic membrane assembly (GO:0097105)4.08586942
6ionotropic glutamate receptor signaling pathway (GO:0035235)3.87355813
7postsynaptic membrane organization (GO:0001941)3.84912863
8olfactory bulb development (GO:0021772)3.83594537
9mRNA splice site selection (GO:0006376)3.82074118
10axonal fasciculation (GO:0007413)3.81133886
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.79382710
12neuron recognition (GO:0008038)3.78818376
13central nervous system projection neuron axonogenesis (GO:0021952)3.76916634
14somite development (GO:0061053)3.69341218
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.64949834
16glutamate receptor signaling pathway (GO:0007215)3.62550240
17presynaptic membrane organization (GO:0097090)3.60534946
18protein localization to synapse (GO:0035418)3.57774888
19sympathetic nervous system development (GO:0048485)3.56582807
20forebrain neuron differentiation (GO:0021879)3.52040883
21negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.48171945
22negative regulation of translation, ncRNA-mediated (GO:0040033)3.48171945
23regulation of translation, ncRNA-mediated (GO:0045974)3.48171945
24vocalization behavior (GO:0071625)3.45174010
25spinal cord development (GO:0021510)3.43652755
26retinal ganglion cell axon guidance (GO:0031290)3.43178166
27regulation of short-term neuronal synaptic plasticity (GO:0048172)3.42847934
28regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.41720642
29positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.40820641
30intraciliary transport (GO:0042073)3.36426135
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.34411610
32regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.34154285
33histone H3-K4 trimethylation (GO:0080182)3.33445842
34regulation of glutamate receptor signaling pathway (GO:1900449)3.30575851
35cerebral cortex radially oriented cell migration (GO:0021799)3.29244380
36synaptic transmission, glutamatergic (GO:0035249)3.29037279
37regulation of non-canonical Wnt signaling pathway (GO:2000050)3.26745376
38pre-miRNA processing (GO:0031054)3.25884704
39G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.21250545
40regulation of development, heterochronic (GO:0040034)3.21116934
41locomotory exploration behavior (GO:0035641)3.20745377
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.17193877
43DNA double-strand break processing (GO:0000729)3.10883250
44dendritic spine morphogenesis (GO:0060997)3.10158011
45regulation of respiratory system process (GO:0044065)3.08504436
46positive regulation of synapse assembly (GO:0051965)3.04326180
47regulation of timing of cell differentiation (GO:0048505)3.03137569
48response to pheromone (GO:0019236)3.02924153
49epithelial cilium movement (GO:0003351)3.02147267
50central nervous system neuron axonogenesis (GO:0021955)3.01604668
51positive regulation of dendritic spine morphogenesis (GO:0061003)3.01179667
52neuron-neuron synaptic transmission (GO:0007270)2.96886894
53dendrite morphogenesis (GO:0048813)2.94946847
54exploration behavior (GO:0035640)2.94196593
55resolution of meiotic recombination intermediates (GO:0000712)2.92389323
56transmission of nerve impulse (GO:0019226)2.88950176
57positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.86392541
58nonmotile primary cilium assembly (GO:0035058)2.82827496
59cerebellar Purkinje cell differentiation (GO:0021702)2.82794771
60spinal cord motor neuron differentiation (GO:0021522)2.82205981
61gastrulation with mouth forming second (GO:0001702)2.82165697
62negative regulation of cytosolic calcium ion concentration (GO:0051481)2.81380771
63protein localization to cilium (GO:0061512)2.80814660
64positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.78438989
65regulation of synapse assembly (GO:0051963)2.77354071
66regulation of respiratory gaseous exchange (GO:0043576)2.77034380
67layer formation in cerebral cortex (GO:0021819)2.76355173
68negative regulation of DNA recombination (GO:0045910)2.75868397
69startle response (GO:0001964)2.74957029
70microtubule anchoring (GO:0034453)2.74753694
71cornea development in camera-type eye (GO:0061303)2.74704321
72establishment of nucleus localization (GO:0040023)2.73933343
73replication fork processing (GO:0031297)2.73011932
74cerebral cortex cell migration (GO:0021795)2.72675192
75cell differentiation in spinal cord (GO:0021515)2.72162088
76synaptic vesicle exocytosis (GO:0016079)2.72005708
77centriole replication (GO:0007099)2.71107131
78neuronal stem cell maintenance (GO:0097150)2.69471368
79calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.68793059
80DNA damage response, detection of DNA damage (GO:0042769)2.68571876
81otic vesicle formation (GO:0030916)2.68381964
82long-term memory (GO:0007616)2.68227116
83DNA topological change (GO:0006265)2.67994279
84dendrite development (GO:0016358)2.67669457
85regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.67432457
86limb development (GO:0060173)2.67081393
87appendage development (GO:0048736)2.67081393
88cerebellum development (GO:0021549)2.66826081
89positive regulation of synapse maturation (GO:0090129)2.64657566
90neuron fate determination (GO:0048664)2.64242875
91behavioral response to ethanol (GO:0048149)2.62484148
92neurotransmitter-gated ion channel clustering (GO:0072578)2.61958850
93regulation of synaptic transmission, glutamatergic (GO:0051966)2.61531615
94microtubule depolymerization (GO:0007019)2.61526546
95histone H2A acetylation (GO:0043968)2.61209275
96cilium organization (GO:0044782)2.60942637
97limb bud formation (GO:0060174)2.60886736
98cilium assembly (GO:0042384)2.60537819
99negative regulation of axon extension (GO:0030517)2.60428909
100innervation (GO:0060384)2.60270436
101gamma-aminobutyric acid signaling pathway (GO:0007214)2.60224746
102behavioral fear response (GO:0001662)2.59142625
103behavioral defense response (GO:0002209)2.59142625
104regulation of excitatory postsynaptic membrane potential (GO:0060079)2.58659595
105regulation of growth hormone secretion (GO:0060123)2.57045428
106synapse assembly (GO:0007416)2.56965132
107regulation of synapse maturation (GO:0090128)2.56433587
108negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.55999883
109regulation of dendritic spine morphogenesis (GO:0061001)2.55892932
110cilium movement (GO:0003341)2.55703980
111cardiac ventricle formation (GO:0003211)2.53811782
112head development (GO:0060322)2.53810736
113regulation of postsynaptic membrane potential (GO:0060078)2.52453278
114regulation of synapse organization (GO:0050807)2.50665969
115negative regulation of DNA-dependent DNA replication (GO:2000104)2.50525460
116spinal cord association neuron differentiation (GO:0021527)2.50510720
117dentate gyrus development (GO:0021542)2.49936589
118negative regulation of axon extension involved in axon guidance (GO:0048843)2.49060489
119mechanosensory behavior (GO:0007638)2.48350597
120negative regulation of oligodendrocyte differentiation (GO:0048715)2.48089803
121positive regulation of synaptic transmission, GABAergic (GO:0032230)2.47766121
122regulation of synaptic vesicle exocytosis (GO:2000300)2.47573857
123cochlea development (GO:0090102)2.47165897
124synaptic vesicle docking involved in exocytosis (GO:0016081)2.46973825
125kinetochore assembly (GO:0051382)2.46340616
126pancreas development (GO:0031016)2.46074292
127cilium morphogenesis (GO:0060271)2.45201506
128neuronal action potential propagation (GO:0019227)2.45063466
129fear response (GO:0042596)2.45047922
130regulation of collateral sprouting (GO:0048670)2.44753781
131microtubule polymerization or depolymerization (GO:0031109)2.44585132
132negative regulation of axon guidance (GO:1902668)2.44444382
133establishment of mitochondrion localization (GO:0051654)2.44120365
134histone H3-K9 methylation (GO:0051567)2.42687608
135behavioral response to nicotine (GO:0035095)2.42219305
136regulation of long-term neuronal synaptic plasticity (GO:0048169)2.41446715
137cranial nerve structural organization (GO:0021604)2.40982304
138neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.40907319
139synaptic vesicle endocytosis (GO:0048488)2.39982316
140regulation of telomere maintenance (GO:0032204)2.39559716
141cranial nerve morphogenesis (GO:0021602)2.39420013
142lateral sprouting from an epithelium (GO:0060601)2.39094526
143embryonic epithelial tube formation (GO:0001838)2.39086181
144cilium or flagellum-dependent cell motility (GO:0001539)2.39070446
145regulation of neuronal synaptic plasticity (GO:0048168)2.38595116
146positive regulation of dendritic spine development (GO:0060999)2.38019319
147neuronal ion channel clustering (GO:0045161)2.37811028
148regulation of axon extension involved in axon guidance (GO:0048841)2.37609650
149hippocampus development (GO:0021766)2.37575037
150ncRNA catabolic process (GO:0034661)2.37298483
151cardiac chamber formation (GO:0003207)2.36816278
152cell migration in hindbrain (GO:0021535)2.36586397
153regulation of axon guidance (GO:1902667)2.35969915
154kidney morphogenesis (GO:0060993)2.35817063
155regulation of oligodendrocyte differentiation (GO:0048713)2.34568432
156negative regulation of transcription regulatory region DNA binding (GO:2000678)2.34164877
157cell differentiation involved in kidney development (GO:0061005)2.34066023
158peptidyl-lysine trimethylation (GO:0018023)2.33874615
159hindbrain development (GO:0030902)2.33517187
160response to histamine (GO:0034776)2.32976196
161* regulation of mRNA splicing, via spliceosome (GO:0048024)2.32881355
162learning (GO:0007612)2.32478278
163glial cell proliferation (GO:0014009)2.31808826
164auditory behavior (GO:0031223)2.29684741
165long-term synaptic potentiation (GO:0060291)2.29596419
166positive regulation of membrane potential (GO:0045838)2.28499123
167mitotic sister chromatid cohesion (GO:0007064)2.27707278
168righting reflex (GO:0060013)2.24515046
169membrane hyperpolarization (GO:0060081)2.23902159

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.79308227
2GBX2_23144817_ChIP-Seq_PC3_Human4.03527899
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87744721
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.83500131
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.61742294
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.56572222
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50492547
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42114398
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.41688357
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41531017
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34310825
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27413833
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26666381
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26666381
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.25085073
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20808611
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.15388926
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13087717
19FUS_26573619_Chip-Seq_HEK293_Human2.12601251
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12364333
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04282084
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03906076
23TAF15_26573619_Chip-Seq_HEK293_Human2.01215762
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.99625752
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.97681447
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96761046
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95599892
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.94830546
29VDR_22108803_ChIP-Seq_LS180_Human1.93221832
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.92329467
31IGF1R_20145208_ChIP-Seq_DFB_Human1.90023483
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86821147
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.86277933
34REST_21632747_ChIP-Seq_MESCs_Mouse1.85526474
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84396257
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82976904
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81024177
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.78597123
39P300_19829295_ChIP-Seq_ESCs_Human1.76624777
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76171648
41DROSHA_22980978_ChIP-Seq_HELA_Human1.72149565
42EWS_26573619_Chip-Seq_HEK293_Human1.70273834
43SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66295339
44SMAD4_21799915_ChIP-Seq_A2780_Human1.58287668
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56773822
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56079888
47RNF2_27304074_Chip-Seq_NSC_Mouse1.56029690
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.55066767
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.54425396
50AR_21572438_ChIP-Seq_LNCaP_Human1.54028573
51ZNF274_21170338_ChIP-Seq_K562_Hela1.53403410
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51410033
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50863246
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49579915
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49273773
56RARB_27405468_Chip-Seq_BRAIN_Mouse1.43504098
57* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40887723
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39722956
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39722956
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38798159
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37479622
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36956098
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32452220
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.31716336
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31269500
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29632423
67CBP_20019798_ChIP-Seq_JUKART_Human1.29632423
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.29209148
69REST_18959480_ChIP-ChIP_MESCs_Mouse1.28041122
70AR_25329375_ChIP-Seq_VCAP_Human1.27603076
71STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.27467600
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27461057
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.26557976
74STAT3_23295773_ChIP-Seq_U87_Human1.26515369
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25944801
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24808948
77IRF1_19129219_ChIP-ChIP_H3396_Human1.24719572
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.24397391
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23897117
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.23375401
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.23196985
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23130118
83RING1B_27294783_Chip-Seq_ESCs_Mouse1.22817792
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22769607
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.22440068
86SOX9_26525672_Chip-Seq_HEART_Mouse1.22133804
87BCAT_22108803_ChIP-Seq_LS180_Human1.21731058
88TCF4_23295773_ChIP-Seq_U87_Human1.20543496
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19801829
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18510041
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17466807
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17300637
93E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17181367
94SOX2_21211035_ChIP-Seq_LN229_Gbm1.16999714
95WT1_19549856_ChIP-ChIP_CCG9911_Human1.15941618
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15262055
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.15011617
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.14971884
99TAL1_26923725_Chip-Seq_HPCs_Mouse1.14886164
100* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14353657
101TBX3_20139965_ChIP-Seq_ESCs_Mouse1.13840821
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13820379
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13482492
104TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13399168
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13165857
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12059456
107TCF4_18268006_ChIP-ChIP_LS174T_Human1.11784531
108TP53_16413492_ChIP-PET_HCT116_Human1.11357520
109RUNX2_22187159_ChIP-Seq_PCA_Human1.10454977
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10292776
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10114449
112TP53_18474530_ChIP-ChIP_U2OS_Human1.08542558
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.08494393
114TCF4_22108803_ChIP-Seq_LS180_Human1.06630829
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06619233
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06427774
117AR_19668381_ChIP-Seq_PC3_Human1.06078358
118ER_23166858_ChIP-Seq_MCF-7_Human1.06040784
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05931797
120CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05435672
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.04981961
122P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04774837
123ELK1_19687146_ChIP-ChIP_HELA_Human1.03662040
124P53_22387025_ChIP-Seq_ESCs_Mouse1.03631172
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02525452
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01946594
127* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00737048
128EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00154425
129VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99633763
130PRDM14_20953172_ChIP-Seq_ESCs_Human0.99240638
131AHR_22903824_ChIP-Seq_MCF-7_Human0.98128259
132CMYC_18555785_Chip-Seq_ESCs_Mouse0.97180626
133* SOX2_16153702_ChIP-ChIP_HESCs_Human0.97164390
134SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95050194
135MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94555238
136MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94149992

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.79830272
2MP0004859_abnormal_synaptic_plasticity3.38607734
3MP0005423_abnormal_somatic_nervous2.83687421
4MP0003635_abnormal_synaptic_transmissio2.65594562
5MP0006292_abnormal_olfactory_placode2.64024263
6MP0003787_abnormal_imprinting2.58199504
7MP0008877_abnormal_DNA_methylation2.45181297
8MP0000778_abnormal_nervous_system2.43533101
9MP0001188_hyperpigmentation2.25830338
10MP0003122_maternal_imprinting2.25055693
11MP0002063_abnormal_learning/memory/cond2.24521893
12MP0009745_abnormal_behavioral_response2.21630946
13MP0004133_heterotaxia2.19446100
14MP0002572_abnormal_emotion/affect_behav2.05392655
15MP0003121_genomic_imprinting2.04884734
16MP0001486_abnormal_startle_reflex2.01343941
17MP0004270_analgesia2.00814161
18MP0001293_anophthalmia1.97379659
19MP0005409_darkened_coat_color1.94988476
20MP0002064_seizures1.87052234
21MP0002184_abnormal_innervation1.83657516
22MP0001968_abnormal_touch/_nociception1.82799206
23MP0006276_abnormal_autonomic_nervous1.74926190
24MP0002557_abnormal_social/conspecific_i1.72565758
25MP0000569_abnormal_digit_pigmentation1.72420799
26MP0000631_abnormal_neuroendocrine_gland1.71636370
27MP0002272_abnormal_nervous_system1.71251858
28MP0002067_abnormal_sensory_capabilities1.68559543
29MP0002938_white_spotting1.64450049
30MP0002822_catalepsy1.64359833
31MP0005248_abnormal_Harderian_gland1.62105045
32MP0005646_abnormal_pituitary_gland1.61902795
33MP0001529_abnormal_vocalization1.59498883
34MP0008057_abnormal_DNA_replication1.59385699
35MP0006072_abnormal_retinal_apoptosis1.59295748
36MP0009046_muscle_twitch1.59273149
37MP0004885_abnormal_endolymph1.57277946
38MP0001286_abnormal_eye_development1.56645043
39MP0001984_abnormal_olfaction1.54967910
40MP0002734_abnormal_mechanical_nocicepti1.54581597
41MP0002102_abnormal_ear_morphology1.51587782
42MP0003119_abnormal_digestive_system1.50930048
43MP0005645_abnormal_hypothalamus_physiol1.49308313
44MP0005394_taste/olfaction_phenotype1.48551453
45MP0005499_abnormal_olfactory_system1.48551453
46MP0003567_abnormal_fetal_cardiomyocyte1.46850415
47MP0002736_abnormal_nociception_after1.46795278
48MP0002638_abnormal_pupillary_reflex1.39957505
49MP0001502_abnormal_circadian_rhythm1.39793419
50MP0000049_abnormal_middle_ear1.39690630
51MP0005386_behavior/neurological_phenoty1.39321800
52MP0004924_abnormal_behavior1.39321800
53MP0005551_abnormal_eye_electrophysiolog1.38406033
54MP0002735_abnormal_chemical_nociception1.38372942
55MP0000955_abnormal_spinal_cord1.35325609
56MP0002697_abnormal_eye_size1.33791157
57MP0008058_abnormal_DNA_repair1.33659365
58MP0002882_abnormal_neuron_morphology1.33296379
59MP0008789_abnormal_olfactory_epithelium1.32476124
60MP0002152_abnormal_brain_morphology1.23047027
61MP0003938_abnormal_ear_development1.22953170
62MP0005253_abnormal_eye_physiology1.22825672
63MP0008569_lethality_at_weaning1.21673904
64MP0003385_abnormal_body_wall1.19278434
65MP0003861_abnormal_nervous_system1.19068838
66MP0002751_abnormal_autonomic_nervous1.18584876
67MP0001501_abnormal_sleep_pattern1.16856578
68MP0002653_abnormal_ependyma_morphology1.15906776
69MP0000566_synostosis1.15591942
70MP0004811_abnormal_neuron_physiology1.14513911
71MP0000516_abnormal_urinary_system1.13831649
72MP0005367_renal/urinary_system_phenotyp1.13831649
73MP0000647_abnormal_sebaceous_gland1.12407455
74MP0001485_abnormal_pinna_reflex1.11763740
75MP0001440_abnormal_grooming_behavior1.06941738
76MP0005171_absent_coat_pigmentation1.06518089
77MP0003890_abnormal_embryonic-extraembry1.06436161
78MP0008995_early_reproductive_senescence1.06056087
79MP0004742_abnormal_vestibular_system1.04605377
80MP0002752_abnormal_somatic_nervous1.03434122
81MP0000026_abnormal_inner_ear1.03344000
82MP0003123_paternal_imprinting1.02757224
83MP0009703_decreased_birth_body1.02732708
84MP0010094_abnormal_chromosome_stability1.01806941
85MP0002733_abnormal_thermal_nociception1.01074848
86MP0002234_abnormal_pharynx_morphology0.98638178
87MP0001970_abnormal_pain_threshold0.97951609
88MP0002249_abnormal_larynx_morphology0.96616889
89MP0002066_abnormal_motor_capabilities/c0.95989798
90MP0009379_abnormal_foot_pigmentation0.95635140
91MP0003942_abnormal_urinary_system0.95559354
92MP0001963_abnormal_hearing_physiology0.94674368
93MP0002092_abnormal_eye_morphology0.92939262
94MP0003937_abnormal_limbs/digits/tail_de0.92697054
95MP0001299_abnormal_eye_distance/0.91145126
96MP0002084_abnormal_developmental_patter0.91121073
97MP0003755_abnormal_palate_morphology0.90820843
98MP0005174_abnormal_tail_pigmentation0.90549034
99MP0002095_abnormal_skin_pigmentation0.89364312
100MP0001324_abnormal_eye_pigmentation0.89268135
101MP0003136_yellow_coat_color0.88898671
102MP0009250_abnormal_appendicular_skeleto0.88833151
103MP0002116_abnormal_craniofacial_bone0.88115765
104MP0001905_abnormal_dopamine_level0.87982468
105MP0003935_abnormal_craniofacial_develop0.87599547
106MP0004142_abnormal_muscle_tone0.86825480
107MP0002177_abnormal_outer_ear0.86210469
108MP0004197_abnormal_fetal_growth/weight/0.85390944
109MP0000015_abnormal_ear_pigmentation0.85288382
110MP0002081_perinatal_lethality0.83204839
111MP0004134_abnormal_chest_morphology0.82152177
112MP0000537_abnormal_urethra_morphology0.80890011
113MP0002009_preneoplasia0.80858328
114MP0010030_abnormal_orbit_morphology0.80719511
115MP0004145_abnormal_muscle_electrophysio0.79440478
116MP0005187_abnormal_penis_morphology0.78754159
117MP0003943_abnormal_hepatobiliary_system0.78737179
118MP0002233_abnormal_nose_morphology0.78466233
119MP0003195_calcinosis0.77580511
120MP0001346_abnormal_lacrimal_gland0.77240158
121MP0005391_vision/eye_phenotype0.76966082
122MP0003137_abnormal_impulse_conducting0.76204144
123MP0005377_hearing/vestibular/ear_phenot0.75534487
124MP0003878_abnormal_ear_physiology0.75534487
125MP0005195_abnormal_posterior_eye0.72708526
126MP0001177_atelectasis0.72203654
127MP0002114_abnormal_axial_skeleton0.72070183
128MP0010386_abnormal_urinary_bladder0.71731463
129MP0003315_abnormal_perineum_morphology0.69741286

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)3.56113650
2Epileptic encephalopathy (HP:0200134)3.12635871
3Abnormality of the labia minora (HP:0012880)3.09937257
4Febrile seizures (HP:0002373)3.07389500
5Protruding tongue (HP:0010808)2.98063306
6Pancreatic cysts (HP:0001737)2.82582542
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.76627063
8Short 4th metacarpal (HP:0010044)2.76627063
9Broad-based gait (HP:0002136)2.74022730
10Colon cancer (HP:0003003)2.73447862
11Cortical dysplasia (HP:0002539)2.66870536
12Progressive cerebellar ataxia (HP:0002073)2.61699830
13Supernumerary spleens (HP:0009799)2.57565521
14Abnormality of the renal medulla (HP:0100957)2.55549837
15Volvulus (HP:0002580)2.55089682
16Focal seizures (HP:0007359)2.54391612
17Vitreoretinal degeneration (HP:0000655)2.40381430
18Excessive salivation (HP:0003781)2.36045236
19Drooling (HP:0002307)2.36045236
20Abnormal lung lobation (HP:0002101)2.23568341
21Postaxial hand polydactyly (HP:0001162)2.21876272
22Postaxial foot polydactyly (HP:0001830)2.21537247
23Atonic seizures (HP:0010819)2.20703491
24Hyperventilation (HP:0002883)2.20561668
25Aplasia/Hypoplasia of the sternum (HP:0006714)2.14092070
26Abnormal hair whorl (HP:0010721)2.14090211
27Tubulointerstitial nephritis (HP:0001970)2.12418283
28Tented upper lip vermilion (HP:0010804)2.09313850
29Septo-optic dysplasia (HP:0100842)2.07865046
30Bifid tongue (HP:0010297)2.07677498
31Abnormality of the pubic bones (HP:0003172)2.07539139
32Absent speech (HP:0001344)2.06707514
33Obsessive-compulsive behavior (HP:0000722)2.06453348
34Medulloblastoma (HP:0002885)2.04075099
35Papillary thyroid carcinoma (HP:0002895)2.03419770
36Exotropia (HP:0000577)2.02620499
37Aqueductal stenosis (HP:0002410)2.02099996
38Morphological abnormality of the middle ear (HP:0008609)2.01866317
39Cutaneous finger syndactyly (HP:0010554)2.00994491
40Thyroiditis (HP:0100646)1.99820098
41Oligodactyly (hands) (HP:0001180)1.99577635
42Genetic anticipation (HP:0003743)1.98079111
43Midline defect of the nose (HP:0004122)1.97852814
44Hip dysplasia (HP:0001385)1.95566383
45Optic nerve hypoplasia (HP:0000609)1.95226509
46Anencephaly (HP:0002323)1.94924792
47Gastrointestinal atresia (HP:0002589)1.94164995
48Dandy-Walker malformation (HP:0001305)1.92285172
49Gait imbalance (HP:0002141)1.91320493
50Intestinal atresia (HP:0011100)1.90667395
51Autism (HP:0000717)1.89234968
52Neoplasm of the adrenal cortex (HP:0100641)1.89128019
53Broad alveolar ridges (HP:0000187)1.88141097
54Widely spaced teeth (HP:0000687)1.87974896
55Cystic liver disease (HP:0006706)1.87934377
56Meckel diverticulum (HP:0002245)1.87548416
57Abnormality of the renal cortex (HP:0011035)1.87359525
58Cutaneous syndactyly (HP:0012725)1.85896017
59Gaze-evoked nystagmus (HP:0000640)1.85279416
60Poor coordination (HP:0002370)1.84732461
61Scrotal hypoplasia (HP:0000046)1.84451442
62Aplasia/Hypoplasia of the uvula (HP:0010293)1.84380885
63Abnormality of the 4th metacarpal (HP:0010012)1.82728519
64Truncal ataxia (HP:0002078)1.82358939
65Renal hypoplasia (HP:0000089)1.82009583
66Narrow nasal bridge (HP:0000446)1.81870443
67Blue irides (HP:0000635)1.81704874
68Abnormality of the ileum (HP:0001549)1.81679149
69Aplasia/Hypoplasia of the tongue (HP:0010295)1.81594069
70Medial flaring of the eyebrow (HP:0010747)1.81579734
71Severe visual impairment (HP:0001141)1.81119012
72Patellar aplasia (HP:0006443)1.80847307
73Anophthalmia (HP:0000528)1.80032391
74Micropenis (HP:0000054)1.79853758
75Inappropriate behavior (HP:0000719)1.79515244
76Nephroblastoma (Wilms tumor) (HP:0002667)1.79477134
77Absent eyebrow (HP:0002223)1.79198250
78Acute lymphatic leukemia (HP:0006721)1.78923851
79Slow-growing hair (HP:0002217)1.78156780
80Abnormality of hair growth rate (HP:0011363)1.78156780
81Narrow forehead (HP:0000341)1.77923316
82Labial hypoplasia (HP:0000066)1.77244985
83Stereotypic behavior (HP:0000733)1.76609494
84Neoplasm of the oral cavity (HP:0100649)1.75524558
85True hermaphroditism (HP:0010459)1.74302704
86Renal duplication (HP:0000075)1.74101359
87Absence seizures (HP:0002121)1.73126160
88Bilateral microphthalmos (HP:0007633)1.73109508
89Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73040772
90Renal cortical cysts (HP:0000803)1.71851810
91Amyotrophic lateral sclerosis (HP:0007354)1.70783109
92Glioma (HP:0009733)1.70696257
93Severe Myopia (HP:0011003)1.70631871
94Embryonal renal neoplasm (HP:0011794)1.70582419
95Preaxial hand polydactyly (HP:0001177)1.70147030
96Molar tooth sign on MRI (HP:0002419)1.69730580
97Abnormality of midbrain morphology (HP:0002418)1.69730580
98Abnormal biliary tract physiology (HP:0012439)1.69084702
99Bile duct proliferation (HP:0001408)1.69084702
100Abnormality of the parietal bone (HP:0002696)1.68661001
101Gastroesophageal reflux (HP:0002020)1.68365528
102Thyroid carcinoma (HP:0002890)1.68265067
103Decreased lacrimation (HP:0000633)1.68059192
104Abnormal respiratory epithelium morphology (HP:0012253)1.67881992
105Abnormal respiratory motile cilium morphology (HP:0005938)1.67881992
106Scanning speech (HP:0002168)1.67365620
107High anterior hairline (HP:0009890)1.67265802
108Broad foot (HP:0001769)1.67243613
109Short philtrum (HP:0000322)1.66841743
110Rhabdomyosarcoma (HP:0002859)1.66261465
111Growth hormone deficiency (HP:0000824)1.66194901
112Congenital primary aphakia (HP:0007707)1.65971174
113Specific learning disability (HP:0001328)1.65929271
114Hyperglycinemia (HP:0002154)1.65248612
115Deeply set eye (HP:0000490)1.65139362
116Hemiparesis (HP:0001269)1.64706687
117Abnormality of chromosome stability (HP:0003220)1.64589124
118Abnormality of the parathyroid morphology (HP:0011766)1.63884208
119Hepatoblastoma (HP:0002884)1.63670988
120Severe combined immunodeficiency (HP:0004430)1.63620866
121Abolished electroretinogram (ERG) (HP:0000550)1.63503253
122Nephrogenic diabetes insipidus (HP:0009806)1.63417190
123Gonadotropin excess (HP:0000837)1.63240509
124Aplasia/Hypoplasia of the tibia (HP:0005772)1.63212916
125Visual hallucinations (HP:0002367)1.61876181
126Thickened helices (HP:0000391)1.61793678
127Heterochromia iridis (HP:0001100)1.61241668
128Alacrima (HP:0000522)1.60892146
129Abnormality of salivation (HP:0100755)1.60801268
130Highly arched eyebrow (HP:0002553)1.58550864
131Genital tract atresia (HP:0001827)1.58052443
132Chronic hepatic failure (HP:0100626)1.57998729
133Lissencephaly (HP:0001339)1.57425775
134Cupped ear (HP:0000378)1.56471461
135Trigonocephaly (HP:0000243)1.56335042
136Thyroid-stimulating hormone excess (HP:0002925)1.56239468
137Abnormality of the phalanges of the hallux (HP:0010057)1.55108194
138Increased nuchal translucency (HP:0010880)1.53160560
139Dialeptic seizures (HP:0011146)1.53154300
140Absent frontal sinuses (HP:0002688)1.53001585
141Vaginal atresia (HP:0000148)1.52020436
142Open mouth (HP:0000194)1.51696611
143Aplasia/Hypoplasia of the brainstem (HP:0007362)1.51665578
144Hypoplasia of the brainstem (HP:0002365)1.51665578
145Anteriorly placed anus (HP:0001545)1.51532694
146Amblyopia (HP:0000646)1.51170619
147Hypoplasia of the maxilla (HP:0000327)1.50813575
148Abnormality of the nasolacrimal system (HP:0000614)1.50427320
149Impaired smooth pursuit (HP:0007772)1.49811375
150Limb dystonia (HP:0002451)1.49660610
151Long nose (HP:0003189)1.49135237
152Elfin facies (HP:0004428)1.48164887
153Megalencephaly (HP:0001355)1.48146412
154Macroorchidism (HP:0000053)1.48145252
155Pancreatic fibrosis (HP:0100732)1.47809666
156Abnormality of the intervertebral disk (HP:0005108)1.47712311
157Embryonal neoplasm (HP:0002898)1.47268840
158Asymmetry of the thorax (HP:0001555)1.47025176
159Abnormality of chromosome segregation (HP:0002916)1.46915215
160Sacral dimple (HP:0000960)1.46894311
161Nephronophthisis (HP:0000090)1.46641584

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.14506425
2MARK13.60030550
3NTRK33.58442427
4CASK3.37534329
5EPHA43.32244493
6MAPK132.77674236
7BRD42.20325851
8NTRK22.17995515
9SIK22.17504842
10FRK2.09228791
11MAP2K72.00687832
12TRIM281.97796281
13ERBB31.91563967
14MAP3K41.86623736
15MKNK21.83808543
16MKNK11.82111848
17PLK41.66609496
18PNCK1.62620766
19SRPK11.59950017
20UHMK11.59812512
21CDC71.58281086
22YES11.56588786
23DYRK1A1.51217937
24MAP4K21.43352212
25SGK21.41158202
26MINK11.37184914
27ACVR1B1.35683033
28CCNB11.35041475
29KSR11.30835646
30BMPR1B1.26637620
31CDK31.22578928
32LATS11.20738260
33EPHA31.19195175
34MAP3K121.15796856
35CAMK1G1.14784937
36SGK2231.11029815
37SGK4941.11029815
38CSNK1G21.09806361
39CSNK1A1L1.09165486
40FGFR21.06158745
41ZAK1.05476738
42PLK21.05385469
43CDK191.02522088
44CDK50.96888896
45CAMKK20.93659188
46STK390.92642267
47NLK0.91809186
48CSNK1G30.91207593
49RPS6KA40.91164243
50WEE10.90993220
51BRSK20.90759555
52AKT30.89785164
53MUSK0.89494182
54WNK30.87711211
55PINK10.83944310
56CAMK2B0.83153994
57OXSR10.83043008
58FES0.82680204
59ADRBK20.81372671
60FGFR10.80857085
61RIPK40.80177142
62STK30.79469424
63MARK20.78917860
64SGK30.78526377
65FLT30.77896336
66CAMK10.75547141
67SIK30.74022718
68SGK10.73217303
69CSNK1G10.72858899
70DYRK20.72724887
71PRPF4B0.71011975
72STK38L0.70490371
73CAMK40.69679594
74ADRBK10.68655665
75TAF10.67234631
76RPS6KA20.66923615
77MAP2K40.66392194
78MAP3K70.66310925
79CDK80.66014639
80CDC42BPA0.65915613
81CAMK2A0.64926870
82WNK10.64877319
83GRK10.64072837
84INSRR0.63673269
85PAK30.63561803
86PRKCG0.63525235
87NUAK10.62721257
88ERBB20.62277206
89ATM0.62207584
90MAP3K100.62047342
91DAPK20.60419114
92EIF2AK30.60404901
93PAK60.59641448
94DAPK10.58874517
95BCR0.58747107
96CDK180.57908553
97TTK0.57714263
98ATR0.57424081
99STK160.57255946
100PLK10.56991863
101WNK40.56121303
102TGFBR10.55951426
103DYRK30.55891838
104NEK60.54791404
105PKN10.53942627
106MAP3K60.53790819
107HIPK20.53619688
108FGFR30.53603657
109CDK150.53349024
110BRAF0.51377945
111EPHB20.50988257
112CDK11A0.49568944
113PIK3CA0.48915238
114CSNK1D0.48724803
115CDK140.48070693
116TSSK60.48065476
117CAMKK10.47844903
118MAPK90.47762277
119GSK3B0.46763767
120MAPK150.46462322
121PHKG10.45909020
122PHKG20.45909020
123PRKG10.44884701
124PLK30.44034794
125DYRK1B0.43922991
126TYRO30.43492613
127CDK10.43449371
128RPS6KB10.43142424
129CSNK1E0.42962914
130PRKCE0.41758384
131CLK10.41605673
132PASK0.41303686
133MAPK100.40505836
134VRK10.39899893
135RPS6KA30.39449895
136STK110.39215983
137PRKDC0.39194792
138MAP3K90.38879649
139BMPR20.38705787
140MAPK80.38632373
141CHEK20.33461002

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.60473086
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.48984197
3Steroid biosynthesis_Homo sapiens_hsa001002.71433381
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35608751
5Circadian entrainment_Homo sapiens_hsa047132.32263463
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.28538871
7Glutamatergic synapse_Homo sapiens_hsa047242.26844608
8Morphine addiction_Homo sapiens_hsa050322.24358220
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.15624656
10Propanoate metabolism_Homo sapiens_hsa006402.15001143
11Long-term potentiation_Homo sapiens_hsa047202.14810187
12Butanoate metabolism_Homo sapiens_hsa006502.07540971
13GABAergic synapse_Homo sapiens_hsa047272.05325844
14Basal transcription factors_Homo sapiens_hsa030222.04080921
15Protein export_Homo sapiens_hsa030602.03428518
16Amphetamine addiction_Homo sapiens_hsa050311.92029906
17Taste transduction_Homo sapiens_hsa047421.86047452
18Olfactory transduction_Homo sapiens_hsa047401.83525337
19Dopaminergic synapse_Homo sapiens_hsa047281.79160759
20Axon guidance_Homo sapiens_hsa043601.69688069
21Serotonergic synapse_Homo sapiens_hsa047261.65518520
22Long-term depression_Homo sapiens_hsa047301.63815216
23Phototransduction_Homo sapiens_hsa047441.59050121
24Cholinergic synapse_Homo sapiens_hsa047251.55428023
25Cocaine addiction_Homo sapiens_hsa050301.51420481
26Insulin secretion_Homo sapiens_hsa049111.48785325
27Renin secretion_Homo sapiens_hsa049241.46540320
28Regulation of autophagy_Homo sapiens_hsa041401.43762331
29Ether lipid metabolism_Homo sapiens_hsa005651.43512599
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43047502
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.40869871
32Salivary secretion_Homo sapiens_hsa049701.39647510
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38207497
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37583408
35Calcium signaling pathway_Homo sapiens_hsa040201.36667092
36Synaptic vesicle cycle_Homo sapiens_hsa047211.36197523
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35478976
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34053470
39Oxytocin signaling pathway_Homo sapiens_hsa049211.29344093
40Gap junction_Homo sapiens_hsa045401.20198760
41Melanogenesis_Homo sapiens_hsa049161.18321111
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17517474
43Wnt signaling pathway_Homo sapiens_hsa043101.17464527
44RNA transport_Homo sapiens_hsa030131.16166475
45TGF-beta signaling pathway_Homo sapiens_hsa043501.16035367
46Alcoholism_Homo sapiens_hsa050341.15864687
47Gastric acid secretion_Homo sapiens_hsa049711.15712739
48cAMP signaling pathway_Homo sapiens_hsa040241.14830478
49Basal cell carcinoma_Homo sapiens_hsa052171.10824987
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.10659683
51Hedgehog signaling pathway_Homo sapiens_hsa043401.05713895
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05013545
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.04945348
54GnRH signaling pathway_Homo sapiens_hsa049121.04838398
55Linoleic acid metabolism_Homo sapiens_hsa005911.03644809
56Fanconi anemia pathway_Homo sapiens_hsa034601.03504260
57Selenocompound metabolism_Homo sapiens_hsa004501.00809505
58mRNA surveillance pathway_Homo sapiens_hsa030150.99572457
59ErbB signaling pathway_Homo sapiens_hsa040120.98526883
60Colorectal cancer_Homo sapiens_hsa052100.98265049
61Oocyte meiosis_Homo sapiens_hsa041140.96356281
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96055178
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94354754
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94184979
65Lysine degradation_Homo sapiens_hsa003100.94019055
66Glioma_Homo sapiens_hsa052140.93281223
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93115127
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92503186
69Spliceosome_Homo sapiens_hsa030400.90640336
70Estrogen signaling pathway_Homo sapiens_hsa049150.88327067
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87867356
72Circadian rhythm_Homo sapiens_hsa047100.87210457
73Endometrial cancer_Homo sapiens_hsa052130.87073466
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86954853
75Peroxisome_Homo sapiens_hsa041460.83954980
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82695770
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82613364
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78787544
79Choline metabolism in cancer_Homo sapiens_hsa052310.78152045
80Fatty acid metabolism_Homo sapiens_hsa012120.77062308
81MAPK signaling pathway_Homo sapiens_hsa040100.75049098
82RNA degradation_Homo sapiens_hsa030180.73842566
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72810938
84Mismatch repair_Homo sapiens_hsa034300.72233850
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71668913
86Dilated cardiomyopathy_Homo sapiens_hsa054140.71033971
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.70800251
88Fat digestion and absorption_Homo sapiens_hsa049750.70715582
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70607720
90Caffeine metabolism_Homo sapiens_hsa002320.70178121
91Non-small cell lung cancer_Homo sapiens_hsa052230.69371758
92Nitrogen metabolism_Homo sapiens_hsa009100.69193426
93Type II diabetes mellitus_Homo sapiens_hsa049300.67621526
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67094910
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.65477093
96Adherens junction_Homo sapiens_hsa045200.65412231
97Tryptophan metabolism_Homo sapiens_hsa003800.65244784
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64039681
99Non-homologous end-joining_Homo sapiens_hsa034500.62862154
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.62819315
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62417357
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62383968
103Notch signaling pathway_Homo sapiens_hsa043300.61470098
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60986232
105ABC transporters_Homo sapiens_hsa020100.60614970
106Dorso-ventral axis formation_Homo sapiens_hsa043200.60436004
107Ras signaling pathway_Homo sapiens_hsa040140.57660166
108Rap1 signaling pathway_Homo sapiens_hsa040150.57341215
109Retinol metabolism_Homo sapiens_hsa008300.57061866
110Tight junction_Homo sapiens_hsa045300.57008597
111Cell cycle_Homo sapiens_hsa041100.56632194
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.56114937
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55033387
114MicroRNAs in cancer_Homo sapiens_hsa052060.55033027
115Pancreatic secretion_Homo sapiens_hsa049720.54186542
116Fatty acid degradation_Homo sapiens_hsa000710.53980366
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.53155673
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50911301
119Hippo signaling pathway_Homo sapiens_hsa043900.50893317
120Cardiac muscle contraction_Homo sapiens_hsa042600.49984635
121Melanoma_Homo sapiens_hsa052180.49957223
122p53 signaling pathway_Homo sapiens_hsa041150.48408741
123Homologous recombination_Homo sapiens_hsa034400.47882612
124Prostate cancer_Homo sapiens_hsa052150.47601160
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47242660
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46567396
127Renal cell carcinoma_Homo sapiens_hsa052110.46395096
128Thyroid hormone synthesis_Homo sapiens_hsa049180.45969243
129T cell receptor signaling pathway_Homo sapiens_hsa046600.45965916
130Pathways in cancer_Homo sapiens_hsa052000.45773070
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45159828
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44670988
133Inositol phosphate metabolism_Homo sapiens_hsa005620.44328510
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42664006
135Fatty acid elongation_Homo sapiens_hsa000620.41803363
136Vibrio cholerae infection_Homo sapiens_hsa051100.41705926
137Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41347264
138Nucleotide excision repair_Homo sapiens_hsa034200.41105205
139Glycerolipid metabolism_Homo sapiens_hsa005610.39883602
140Base excision repair_Homo sapiens_hsa034100.39586355
141DNA replication_Homo sapiens_hsa030300.39411532
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.37331730
143FoxO signaling pathway_Homo sapiens_hsa040680.30729071

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