ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.68136213
2	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.10838409
3	L-fucose catabolic process (GO:0042355)	3.92189686
4	fucose catabolic process (GO:0019317)	3.92189686
5	L-fucose metabolic process (GO:0042354)	3.92189686
6	response to pheromone (GO:0019236)	3.86387016
7	indole-containing compound catabolic process (GO:0042436)	3.82334957
8	indolalkylamine catabolic process (GO:0046218)	3.82334957
9	tryptophan catabolic process (GO:0006569)	3.82334957
10	kynurenine metabolic process (GO:0070189)	3.60831631
11	proline transport (GO:0015824)	3.56127795
12	tryptophan metabolic process (GO:0006568)	3.52046193
13	indolalkylamine metabolic process (GO:0006586)	3.39560904
14	platelet dense granule organization (GO:0060155)	3.32779333
15	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.32227692
16	gamma-aminobutyric acid transport (GO:0015812)	3.27597732
17	cellular ketone body metabolic process (GO:0046950)	3.23230684
18	neuronal action potential propagation (GO:0019227)	3.06034463
19	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.02246984
20	DNA deamination (GO:0045006)	3.01538926
21	oxidative demethylation (GO:0070989)	2.97918391
22	amine catabolic process (GO:0009310)	2.95688253
23	cellular biogenic amine catabolic process (GO:0042402)	2.95688253
24	ketone body metabolic process (GO:1902224)	2.93228457
25	inositol phosphate catabolic process (GO:0071545)	2.90209817
26	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.90111742
27	pyrimidine nucleobase catabolic process (GO:0006208)	2.89700695
28	preassembly of GPI anchor in ER membrane (GO:0016254)	2.86767520
29	S-adenosylmethionine metabolic process (GO:0046500)	2.84222820
30	neural tube formation (GO:0001841)	2.83274563
31	neuronal action potential (GO:0019228)	2.82107458
32	indole-containing compound metabolic process (GO:0042430)	2.76639595
33	membrane depolarization during action potential (GO:0086010)	2.75677747
34	startle response (GO:0001964)	2.75270322
35	aromatic amino acid family catabolic process (GO:0009074)	2.73248914
36	detection of light stimulus involved in sensory perception (GO:0050962)	2.69731034
37	detection of light stimulus involved in visual perception (GO:0050908)	2.69731034
38	piRNA metabolic process (GO:0034587)	2.69322580
39	drug catabolic process (GO:0042737)	2.68992772
40	inositol phosphate dephosphorylation (GO:0046855)	2.68710837
41	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.68710837
42	synaptic vesicle maturation (GO:0016188)	2.66130310
43	cellular response to exogenous dsRNA (GO:0071360)	2.65751142
44	nucleobase catabolic process (GO:0046113)	2.65527197
45	glycosphingolipid biosynthetic process (GO:0006688)	2.65438785
46	regulation of action potential (GO:0098900)	2.65103498
47	DNA methylation involved in gamete generation (GO:0043046)	2.65070221
48	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.64903461
49	dendritic spine morphogenesis (GO:0060997)	2.62568906
50	auditory receptor cell stereocilium organization (GO:0060088)	2.62071512
51	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.58301973
52	neuromuscular synaptic transmission (GO:0007274)	2.55717287
53	cellular response to ATP (GO:0071318)	2.55221571
54	C4-dicarboxylate transport (GO:0015740)	2.52938522
55	axoneme assembly (GO:0035082)	2.51772184
56	protein import into peroxisome matrix (GO:0016558)	2.51004801
57	regulation of glucokinase activity (GO:0033131)	2.50617640
58	regulation of hexokinase activity (GO:1903299)	2.50617640
59	exogenous drug catabolic process (GO:0042738)	2.49930391
60	cytochrome complex assembly (GO:0017004)	2.49136296
61	central nervous system myelination (GO:0022010)	2.48234056
62	axon ensheathment in central nervous system (GO:0032291)	2.48234056
63	protein complex biogenesis (GO:0070271)	2.42674842
64	glycerophospholipid catabolic process (GO:0046475)	2.41371445
65	alanine transport (GO:0032328)	2.40545155
66	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.40449721
67	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.39828677
68	water-soluble vitamin biosynthetic process (GO:0042364)	2.39366605
69	positive regulation of fatty acid transport (GO:2000193)	2.37887746
70	negative regulation of mast cell activation (GO:0033004)	2.37572063
71	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.37562351
72	reflex (GO:0060004)	2.34721572
73	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.33690719
74	polyol catabolic process (GO:0046174)	2.33317969
75	regulation of neurotransmitter uptake (GO:0051580)	2.32887200
76	action potential (GO:0001508)	2.29718372
77	spinal cord motor neuron differentiation (GO:0021522)	2.28874095
78	respiratory chain complex IV assembly (GO:0008535)	2.27403109
79	sulfation (GO:0051923)	2.26791432
80	cellular potassium ion transport (GO:0071804)	2.26424705
81	potassium ion transmembrane transport (GO:0071805)	2.26424705
82	neurotransmitter metabolic process (GO:0042133)	2.26092956
83	retinal cone cell development (GO:0046549)	2.24843930
84	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.24797678
85	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.24752622
86	transmission of nerve impulse (GO:0019226)	2.24419985
87	synaptic transmission, glutamatergic (GO:0035249)	2.21352826
88	dentate gyrus development (GO:0021542)	2.21275217
89	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.21262892
90	potassium ion transport (GO:0006813)	2.20200114
91	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.20030702
92	transepithelial transport (GO:0070633)	2.19985471
93	primary amino compound metabolic process (GO:1901160)	2.19777886
94	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.18358324
95	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.18184699
96	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.18184699
97	presynaptic membrane organization (GO:0097090)	2.18033698
98	regulation of sarcomere organization (GO:0060297)	2.17143535
99	neuron-neuron synaptic transmission (GO:0007270)	2.16614939
100	protein K11-linked deubiquitination (GO:0035871)	2.16411493

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.59707549
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.55495793
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.94450311
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.81384404
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.60632424
6	VDR_22108803_ChIP-Seq_LS180_Human	2.42887220
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.23179159
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.21446694
9	REST_21632747_ChIP-Seq_MESCs_Mouse	1.94952965
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.93750743
11	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.84917039
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.81342567
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.79592740
14	TAF15_26573619_Chip-Seq_HEK293_Human	1.74181218
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.73271654
16	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.65916468
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.64511570
18	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.59544556
19	P300_19829295_ChIP-Seq_ESCs_Human	1.58781494
20	FUS_26573619_Chip-Seq_HEK293_Human	1.57094355
21	DROSHA_22980978_ChIP-Seq_HELA_Human	1.56785581
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.53236416
23	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.52985530
24	* BCAT_22108803_ChIP-Seq_LS180_Human	1.52291011
25	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.50729881
26	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.50397394
27	TCF4_23295773_ChIP-Seq_U87_Human	1.47898772
28	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.46416727
29	CBP_20019798_ChIP-Seq_JUKART_Human	1.46388994
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.46388994
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.45378650
32	STAT3_23295773_ChIP-Seq_U87_Human	1.43404926
33	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.41380773
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.37234715
35	SMAD4_21799915_ChIP-Seq_A2780_Human	1.36425889
36	AR_25329375_ChIP-Seq_VCAP_Human	1.36319499
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35286534
38	EWS_26573619_Chip-Seq_HEK293_Human	1.33907945
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.32944933
40	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.28452027
41	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.28242460
42	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28242460
43	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.26962669
44	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.25946680
45	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.25897277
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.25078865
47	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24711044
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.22563281
49	NCOR_22424771_ChIP-Seq_293T_Human	1.21791317
50	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.21735007
51	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.21080676
52	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.18405963
53	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.18200557
54	AR_21572438_ChIP-Seq_LNCaP_Human	1.18032172
55	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15123485
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14811241
57	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.14450475
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13541442
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13541442
60	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.12754450
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12503491
62	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.12433577
63	* TCF4_22108803_ChIP-Seq_LS180_Human	1.09626611
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09501428
65	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09324909
66	* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.09066506
67	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08541591
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07613531
69	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07316474
70	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.06190378
71	TAF2_19829295_ChIP-Seq_ESCs_Human	1.06187344
72	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.05966797
73	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.05956293
74	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04802903
75	IRF1_19129219_ChIP-ChIP_H3396_Human	1.04605174
76	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.04240619
77	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.04104335
78	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.03737672
79	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.02986797
80	RNF2_27304074_Chip-Seq_NSC_Mouse	1.02208417
81	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.02052718
82	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.01912629
83	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.01897051
84	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.01165371
85	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.00834653
86	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.00834653
87	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00115033
88	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99725390
89	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.99428705
90	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.99370191
91	ERA_21632823_ChIP-Seq_H3396_Human	0.98273528
92	MYC_19829295_ChIP-Seq_ESCs_Human	0.97748668
93	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.97725999
94	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.97604273
95	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96935730
96	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.96499384
97	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.96350433
98	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.96246201
99	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.96183396
100	AR_20517297_ChIP-Seq_VCAP_Human	0.94063834

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	3.03987217
2	MP0003195_calcinosis	2.75970673
3	MP0008877_abnormal_DNA_methylation	2.43311604
4	MP0001968_abnormal_touch/_nociception	2.42726219
5	MP0009745_abnormal_behavioral_response	2.29008177
6	MP0008875_abnormal_xenobiotic_pharmacok	2.28874089
7	MP0003880_abnormal_central_pattern	2.27394672
8	MP0001986_abnormal_taste_sensitivity	2.24433715
9	MP0002272_abnormal_nervous_system	2.20659110
10	MP0009046_muscle_twitch	2.12448290
11	MP0005551_abnormal_eye_electrophysiolog	2.10394848
12	MP0005645_abnormal_hypothalamus_physiol	2.07606338
13	MP0008872_abnormal_physiological_respon	2.06768117
14	MP0002163_abnormal_gland_morphology	2.06284811
15	MP0002876_abnormal_thyroid_physiology	2.05570198
16	MP0002064_seizures	2.00664957
17	MP0002138_abnormal_hepatobiliary_system	1.98741827
18	MP0003646_muscle_fatigue	1.97350792
19	MP0005423_abnormal_somatic_nervous	1.91140127
20	MP0002638_abnormal_pupillary_reflex	1.90463418
21	MP0004145_abnormal_muscle_electrophysio	1.87938645
22	MP0001501_abnormal_sleep_pattern	1.85945740
23	MP0001984_abnormal_olfaction	1.82458753
24	MP0003635_abnormal_synaptic_transmissio	1.82000035
25	MP0002837_dystrophic_cardiac_calcinosis	1.81704856
26	MP0001486_abnormal_startle_reflex	1.75971536
27	MP0005646_abnormal_pituitary_gland	1.64367178
28	MP0004859_abnormal_synaptic_plasticity	1.59611856
29	MP0002572_abnormal_emotion/affect_behav	1.55740756
30	MP0005379_endocrine/exocrine_gland_phen	1.55166265
31	MP0004924_abnormal_behavior	1.54890964
32	MP0005386_behavior/neurological_phenoty	1.54890964
33	MP0004270_analgesia	1.53641626
34	MP0004043_abnormal_pH_regulation	1.53603512
35	MP0002063_abnormal_learning/memory/cond	1.53520721
36	MP0005174_abnormal_tail_pigmentation	1.53520684
37	MP0000569_abnormal_digit_pigmentation	1.51467384
38	MP0003252_abnormal_bile_duct	1.49797697
39	MP0006276_abnormal_autonomic_nervous	1.48038257
40	MP0002928_abnormal_bile_duct	1.47969125
41	MP0001970_abnormal_pain_threshold	1.45477613
42	MP0004885_abnormal_endolymph	1.43029332
43	MP0004147_increased_porphyrin_level	1.42250501
44	MP0002734_abnormal_mechanical_nocicepti	1.40967938
45	MP0002733_abnormal_thermal_nociception	1.37133683
46	MP0002735_abnormal_chemical_nociception	1.32187900
47	MP0010386_abnormal_urinary_bladder	1.31252277
48	MP0002102_abnormal_ear_morphology	1.29465793
49	MP0006072_abnormal_retinal_apoptosis	1.27556224
50	MP0004142_abnormal_muscle_tone	1.26587328
51	MP0002736_abnormal_nociception_after	1.26453533
52	MP0005084_abnormal_gallbladder_morpholo	1.26143387
53	MP0000427_abnormal_hair_cycle	1.25898389
54	MP0003172_abnormal_lysosome_physiology	1.24285873
55	MP0002067_abnormal_sensory_capabilities	1.20324315
56	MP0000015_abnormal_ear_pigmentation	1.16809949
57	MP0001485_abnormal_pinna_reflex	1.16545029
58	MP0002557_abnormal_social/conspecific_i	1.14887144
59	MP0005253_abnormal_eye_physiology	1.14709332
60	MP0003879_abnormal_hair_cell	1.12787674
61	MP0001502_abnormal_circadian_rhythm	1.08810650
62	MP0005075_abnormal_melanosome_morpholog	1.06223387
63	MP0002229_neurodegeneration	1.01272664
64	MP0005167_abnormal_blood-brain_barrier	1.00737907
65	MP0010329_abnormal_lipoprotein_level	1.00700451
66	MP0004742_abnormal_vestibular_system	1.00355002
67	MP0001905_abnormal_dopamine_level	1.00076321
68	MP0002160_abnormal_reproductive_system	0.98167561
69	MP0005671_abnormal_response_to	0.97461117
70	MP0003183_abnormal_peptide_metabolism	0.94381531
71	MP0004130_abnormal_muscle_cell	0.93640227
72	MP0002653_abnormal_ependyma_morphology	0.88992724
73	MP0001835_abnormal_antigen_presentation	0.87030918
74	MP0005220_abnormal_exocrine_pancreas	0.86431200
75	MP0004215_abnormal_myocardial_fiber	0.86314559
76	MP0002693_abnormal_pancreas_physiology	0.84717176
77	MP0005389_reproductive_system_phenotype	0.84105377
78	MP0006292_abnormal_olfactory_placode	0.84058721
79	MP0005332_abnormal_amino_acid	0.83988814
80	MP0001756_abnormal_urination	0.83703841
81	MP0005365_abnormal_bile_salt	0.82677424
82	MP0001440_abnormal_grooming_behavior	0.81557810
83	MP0004133_heterotaxia	0.80566331
84	MP0000230_abnormal_systemic_arterial	0.80283293
85	MP0005448_abnormal_energy_balance	0.79910791
86	MP0003121_genomic_imprinting	0.78739871
87	MP0004085_abnormal_heartbeat	0.77875838
88	MP0005410_abnormal_fertilization	0.77733384
89	MP0000372_irregular_coat_pigmentation	0.77498516
90	MP0003633_abnormal_nervous_system	0.76477616
91	MP0001765_abnormal_ion_homeostasis	0.76161797
92	MP0000631_abnormal_neuroendocrine_gland	0.75765555
93	MP0002095_abnormal_skin_pigmentation	0.74354213
94	MP0005535_abnormal_body_temperature	0.73036225
95	MP0005310_abnormal_salivary_gland	0.71366968
96	MP0001529_abnormal_vocalization	0.71235133
97	MP0002066_abnormal_motor_capabilities/c	0.71153642
98	MP0002882_abnormal_neuron_morphology	0.69382799
99	MP0002069_abnormal_eating/drinking_beha	0.68736708
100	MP0008775_abnormal_heart_ventricle	0.67369295

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	3.54137407
2	Febrile seizures (HP:0002373)	3.46409652
3	Focal motor seizures (HP:0011153)	3.45641131
4	Pancreatic cysts (HP:0001737)	3.44216198
5	Gaze-evoked nystagmus (HP:0000640)	3.27418156
6	Focal seizures (HP:0007359)	3.20570703
7	Congenital stationary night blindness (HP:0007642)	3.13403058
8	Progressive cerebellar ataxia (HP:0002073)	3.11204984
9	Abnormality of the renal cortex (HP:0011035)	3.04180664
10	Type II lissencephaly (HP:0007260)	3.01296792
11	Attenuation of retinal blood vessels (HP:0007843)	2.96516826
12	Molar tooth sign on MRI (HP:0002419)	2.92500515
13	Abnormality of midbrain morphology (HP:0002418)	2.92500515
14	Nephronophthisis (HP:0000090)	2.83969790
15	Abolished electroretinogram (ERG) (HP:0000550)	2.78700491
16	Pancreatic fibrosis (HP:0100732)	2.76021367
17	Abnormal drinking behavior (HP:0030082)	2.74742511
18	Polydipsia (HP:0001959)	2.74742511
19	Genetic anticipation (HP:0003743)	2.74004346
20	True hermaphroditism (HP:0010459)	2.62026710
21	Decreased circulating renin level (HP:0003351)	2.60569938
22	Broad-based gait (HP:0002136)	2.58122903
23	Abnormality of the renal medulla (HP:0100957)	2.54766669
24	Hemiparesis (HP:0001269)	2.54114468
25	Dialeptic seizures (HP:0011146)	2.53152630
26	Progressive inability to walk (HP:0002505)	2.52899998
27	Protruding tongue (HP:0010808)	2.48316890
28	Epileptic encephalopathy (HP:0200134)	2.46746586
29	Inability to walk (HP:0002540)	2.46682081
30	Ketoacidosis (HP:0001993)	2.45799819
31	Chronic hepatic failure (HP:0100626)	2.42378497
32	Abnormal rod and cone electroretinograms (HP:0008323)	2.39178773
33	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.36746775
34	Visual hallucinations (HP:0002367)	2.34577417
35	Large for gestational age (HP:0001520)	2.31903060
36	Medial flaring of the eyebrow (HP:0010747)	2.29160192
37	Ketosis (HP:0001946)	2.28217245
38	Lissencephaly (HP:0001339)	2.27253524
39	Thyroiditis (HP:0100646)	2.26563278
40	Renal cortical cysts (HP:0000803)	2.21236534
41	Panhypogammaglobulinemia (HP:0003139)	2.20938637
42	Polyuria (HP:0000103)	2.20069924
43	Absence seizures (HP:0002121)	2.19955310
44	Stomatitis (HP:0010280)	2.19501189
45	Generalized tonic-clonic seizures (HP:0002069)	2.17122365
46	Cystic liver disease (HP:0006706)	2.15245556
47	Methylmalonic aciduria (HP:0012120)	2.12845267
48	Decreased central vision (HP:0007663)	2.10623863
49	Methylmalonic acidemia (HP:0002912)	2.07261482
50	Increased CSF lactate (HP:0002490)	2.04567330
51	Clumsiness (HP:0002312)	2.03284496
52	Atonic seizures (HP:0010819)	2.03203721
53	Absent speech (HP:0001344)	2.00787921
54	Mitochondrial inheritance (HP:0001427)	2.00446665
55	Cerebellar dysplasia (HP:0007033)	2.00323082
56	Neoplasm of the adrenal cortex (HP:0100641)	1.99838790
57	Pachygyria (HP:0001302)	1.97032840
58	Metabolic alkalosis (HP:0200114)	1.96048344
59	Status epilepticus (HP:0002133)	1.95760340
60	Bony spicule pigmentary retinopathy (HP:0007737)	1.95091110
61	Hypothermia (HP:0002045)	1.94873199
62	Polyphagia (HP:0002591)	1.92967109
63	Albinism (HP:0001022)	1.92922547
64	Fair hair (HP:0002286)	1.91858730
65	Widely spaced teeth (HP:0000687)	1.90770635
66	Hemiplegia (HP:0002301)	1.90276401
67	Calf muscle hypertrophy (HP:0008981)	1.90252958
68	Pendular nystagmus (HP:0012043)	1.90229372
69	Severe muscular hypotonia (HP:0006829)	1.88271188
70	Agitation (HP:0000713)	1.86029793
71	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.84979716
72	Hepatocellular necrosis (HP:0001404)	1.84271144
73	Dyskinesia (HP:0100660)	1.83875590
74	Prolonged QT interval (HP:0001657)	1.83099168
75	Abnormality of B cell number (HP:0010975)	1.81773922
76	Stomach cancer (HP:0012126)	1.81371606
77	Tubular atrophy (HP:0000092)	1.80865211
78	Hepatic necrosis (HP:0002605)	1.80754844
79	Muscle hypertrophy of the lower extremities (HP:0008968)	1.80615761
80	Gait imbalance (HP:0002141)	1.80020073
81	Abnormal urine output (HP:0012590)	1.78083822
82	Congenital sensorineural hearing impairment (HP:0008527)	1.74591735
83	Progressive macrocephaly (HP:0004481)	1.73463384
84	Progressive microcephaly (HP:0000253)	1.72725958
85	Lipid accumulation in hepatocytes (HP:0006561)	1.71963128
86	Retinal dysplasia (HP:0007973)	1.71376116
87	Optic disc pallor (HP:0000543)	1.69173482
88	Congenital hepatic fibrosis (HP:0002612)	1.68594723
89	Epileptiform EEG discharges (HP:0011182)	1.67481132
90	Hyperglycinuria (HP:0003108)	1.66293660
91	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.65961161
92	Amyotrophic lateral sclerosis (HP:0007354)	1.65516625
93	EEG with generalized epileptiform discharges (HP:0011198)	1.64848428
94	Tachypnea (HP:0002789)	1.64618116
95	Hypsarrhythmia (HP:0002521)	1.63584665
96	Abnormality of renin-angiotensin system (HP:0000847)	1.61366840
97	Hematochezia (HP:0002573)	1.60020319
98	Bundle branch block (HP:0011710)	1.60001634
99	Hypomagnesemia (HP:0002917)	1.59863643
100	Generalized hypopigmentation of hair (HP:0011358)	1.59720743

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.19577845
2	ADRBK2	2.97354946
3	PINK1	2.91255939
4	DAPK2	2.35323523
5	BMPR1B	2.34207075
6	GRK1	2.28839998
7	TAOK3	2.25949805
8	MAPK13	2.16674277
9	MAP4K2	2.13458412
10	PHKG2	1.99100644
11	PHKG1	1.99100644
12	MARK1	1.92801376
13	WNK4	1.90980690
14	NTRK3	1.63022546
15	PAK3	1.60761776
16	TLK1	1.59404359
17	INSRR	1.56665237
18	MAP3K4	1.51782362
19	WNK3	1.50965911
20	OBSCN	1.48573664
21	ZAK	1.48336005
22	TXK	1.46499971
23	OXSR1	1.44264072
24	CAMKK2	1.41469352
25	EPHA4	1.36921977
26	SIK2	1.30294810
27	ACVR1B	1.29635687
28	CASK	1.23743824
29	FGFR2	1.18683333
30	NTRK2	1.13670378
31	TNK2	1.12823528
32	NUAK1	1.12289146
33	CAMKK1	1.11863213
34	TNIK	1.08895239
35	KIT	1.05470557
36	PAK6	1.01403300
37	SYK	0.96071270
38	STK39	0.95992994
39	STK11	0.94613344
40	PLK2	0.92499317
41	CAMK1	0.92301530
42	ADRBK1	0.91993843
43	PRKCE	0.89855200
44	PRKCQ	0.88299338
45	PRKCG	0.83399558
46	LMTK2	0.82929844
47	ITK	0.80913445
48	MAP4K1	0.80429146
49	MUSK	0.74172036
50	PRKD3	0.73983055
51	MAP2K6	0.71415020
52	TRIM28	0.71369241
53	SGK2	0.70624211
54	TEC	0.68266858
55	PTK2B	0.68167128
56	CAMK2A	0.66780655
57	PKN1	0.66604377
58	CAMK4	0.65108721
59	MINK1	0.64784319
60	PIK3CA	0.64741151
61	MAP2K7	0.63318394
62	DYRK1A	0.62322784
63	BCKDK	0.61743369
64	GRK6	0.60450602
65	PRKCI	0.59894112
66	PRKAA1	0.59375287
67	MAPKAPK3	0.58409074
68	MAPK12	0.57184823
69	FLT3	0.57150273
70	IKBKB	0.57122749
71	AKT3	0.55720598
72	PRKG1	0.55132805
73	SGK494	0.54427988
74	SGK223	0.54427988
75	PRKACA	0.53708046
76	NLK	0.53614943
77	MAP3K7	0.53270526
78	FES	0.53026583
79	CAMK2D	0.51272779
80	GRK5	0.50889531
81	GRK7	0.50872670
82	IKBKE	0.48515164
83	PIK3CG	0.46945863
84	PRKCH	0.46720557
85	DYRK2	0.46131221
86	MAP2K4	0.45180210
87	CSNK1G2	0.44994806
88	SIK3	0.44968544
89	CDK5	0.44442480
90	PRKAA2	0.43271891
91	PRKCZ	0.43060072
92	CSF1R	0.42387479
93	TGFBR1	0.42298134
94	WNK1	0.42160512
95	CSNK1A1L	0.41738193
96	HIPK2	0.41448980
97	IRAK1	0.41113090
98	PRKCA	0.40503844
99	LYN	0.39754995
100	BLK	0.39616796

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.80152698
2	Caffeine metabolism_Homo sapiens_hsa00232	2.77344597
3	Nicotine addiction_Homo sapiens_hsa05033	2.47342245
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.30248107
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.10379305
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.00771756
7	Insulin secretion_Homo sapiens_hsa04911	1.99604171
8	Butanoate metabolism_Homo sapiens_hsa00650	1.99368411
9	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.97723246
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.93737913
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.90197681
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.85138154
13	Morphine addiction_Homo sapiens_hsa05032	1.84195487
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.82896674
15	Olfactory transduction_Homo sapiens_hsa04740	1.79904820
16	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.75506368
17	Circadian entrainment_Homo sapiens_hsa04713	1.73949744
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.73827907
19	Asthma_Homo sapiens_hsa05310	1.72061992
20	Primary immunodeficiency_Homo sapiens_hsa05340	1.62879657
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.62298622
22	GABAergic synapse_Homo sapiens_hsa04727	1.58185654
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.53870987
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.52984894
25	Glutamatergic synapse_Homo sapiens_hsa04724	1.50481406
26	Taste transduction_Homo sapiens_hsa04742	1.49909791
27	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.49050426
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.45351893
29	Peroxisome_Homo sapiens_hsa04146	1.43859845
30	ABC transporters_Homo sapiens_hsa02010	1.43346570
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.38374658
32	Calcium signaling pathway_Homo sapiens_hsa04020	1.32901255
33	Circadian rhythm_Homo sapiens_hsa04710	1.31595115
34	Regulation of autophagy_Homo sapiens_hsa04140	1.30644274
35	Type I diabetes mellitus_Homo sapiens_hsa04940	1.22933893
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.22880632
37	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.19211162
38	Selenocompound metabolism_Homo sapiens_hsa00450	1.18571350
39	Salivary secretion_Homo sapiens_hsa04970	1.15772452
40	Gastric acid secretion_Homo sapiens_hsa04971	1.13763244
41	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.10021023
42	Collecting duct acid secretion_Homo sapiens_hsa04966	1.08161902
43	Allograft rejection_Homo sapiens_hsa05330	1.05054081
44	Oxidative phosphorylation_Homo sapiens_hsa00190	1.02741976
45	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.02435437
46	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.01832564
47	Cardiac muscle contraction_Homo sapiens_hsa04260	0.98500532
48	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.98359936
49	Serotonergic synapse_Homo sapiens_hsa04726	0.97701311
50	Amphetamine addiction_Homo sapiens_hsa05031	0.97243194
51	Dopaminergic synapse_Homo sapiens_hsa04728	0.96896245
52	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.95413506
53	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.94414404
54	beta-Alanine metabolism_Homo sapiens_hsa00410	0.92327647
55	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.91568746
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.90052861
57	Renin secretion_Homo sapiens_hsa04924	0.88768678
58	Retinol metabolism_Homo sapiens_hsa00830	0.88575192
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.84896936
60	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.83532385
61	Graft-versus-host disease_Homo sapiens_hsa05332	0.83167933
62	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.82277435
63	Propanoate metabolism_Homo sapiens_hsa00640	0.82033629
64	Cholinergic synapse_Homo sapiens_hsa04725	0.81479328
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.79962828
66	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.79151296
67	Histidine metabolism_Homo sapiens_hsa00340	0.78317042
68	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.71595444
69	cAMP signaling pathway_Homo sapiens_hsa04024	0.70576647
70	Parkinsons disease_Homo sapiens_hsa05012	0.69078381
71	Fatty acid degradation_Homo sapiens_hsa00071	0.68532926
72	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.66401599
73	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.65972840
74	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.65804913
75	Bile secretion_Homo sapiens_hsa04976	0.65695059
76	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.63862316
77	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.62673439
78	Fanconi anemia pathway_Homo sapiens_hsa03460	0.61500426
79	Cocaine addiction_Homo sapiens_hsa05030	0.60176575
80	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.58945950
81	RNA degradation_Homo sapiens_hsa03018	0.55497845
82	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.54284596
83	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.53395253
84	Long-term depression_Homo sapiens_hsa04730	0.52925740
85	RNA polymerase_Homo sapiens_hsa03020	0.52752836
86	Type II diabetes mellitus_Homo sapiens_hsa04930	0.49777188
87	Protein export_Homo sapiens_hsa03060	0.49772574
88	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.48174407
89	Lysine degradation_Homo sapiens_hsa00310	0.46967416
90	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.46712456
91	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.46443732
92	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.45189573
93	Alzheimers disease_Homo sapiens_hsa05010	0.44462253
94	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.44327442
95	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44061996
96	Basal transcription factors_Homo sapiens_hsa03022	0.44043893
97	Rheumatoid arthritis_Homo sapiens_hsa05323	0.43341397
98	Glucagon signaling pathway_Homo sapiens_hsa04922	0.41677561
99	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.41244516
100	Pancreatic secretion_Homo sapiens_hsa04972	0.40650723

TIAF1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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