TIAL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1startle response (GO:0001964)5.28119047
2regulation of DNA endoreduplication (GO:0032875)4.76297224
3ionotropic glutamate receptor signaling pathway (GO:0035235)4.41571414
4keratinocyte development (GO:0003334)4.24610688
5neurotransmitter-gated ion channel clustering (GO:0072578)4.20310433
6synaptic transmission, glutamatergic (GO:0035249)4.16911129
7negative regulation of DNA-dependent DNA replication (GO:2000104)4.10521363
8presynaptic membrane assembly (GO:0097105)4.02254976
9regulation of short-term neuronal synaptic plasticity (GO:0048172)3.97278152
10mitotic sister chromatid cohesion (GO:0007064)3.96604277
11replication fork processing (GO:0031297)3.93728787
12synaptic vesicle docking involved in exocytosis (GO:0016081)3.90093725
13kidney morphogenesis (GO:0060993)3.89656590
14regulation of nuclear cell cycle DNA replication (GO:0033262)3.82919545
15water-soluble vitamin biosynthetic process (GO:0042364)3.80615970
16synaptic vesicle endocytosis (GO:0048488)3.78969467
17synaptic vesicle maturation (GO:0016188)3.78838587
18dorsal/ventral axis specification (GO:0009950)3.74788732
19glutamate receptor signaling pathway (GO:0007215)3.70271191
20neuron-neuron synaptic transmission (GO:0007270)3.66407484
21positive regulation of mitotic sister chromatid separation (GO:1901970)3.66351161
22positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.66351161
23positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.66351161
24neuron cell-cell adhesion (GO:0007158)3.66115423
25DNA double-strand break processing (GO:0000729)3.61123915
26presynaptic membrane organization (GO:0097090)3.60611706
27regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.59513306
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.57664434
29mRNA splice site selection (GO:0006376)3.55814339
30postsynaptic membrane organization (GO:0001941)3.54699817
31regulation of synaptic vesicle exocytosis (GO:2000300)3.53711991
32limb bud formation (GO:0060174)3.52962692
33positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.52539407
34cerebellar Purkinje cell differentiation (GO:0021702)3.48868345
35vocalization behavior (GO:0071625)3.47267870
36respiratory chain complex IV assembly (GO:0008535)3.40478926
37locomotory exploration behavior (GO:0035641)3.37838392
38regulation of glutamate receptor signaling pathway (GO:1900449)3.30935340
39regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.30746787
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.27242316
41gamma-aminobutyric acid transport (GO:0015812)3.24799792
42sister chromatid cohesion (GO:0007062)3.23252759
43synapsis (GO:0007129)3.21829094
44cornea development in camera-type eye (GO:0061303)3.19810006
45dentate gyrus development (GO:0021542)3.18764376
46cerebellar granule cell differentiation (GO:0021707)3.16596305
47neuronal action potential propagation (GO:0019227)3.16448268
48regulation of hexokinase activity (GO:1903299)3.15947220
49regulation of glucokinase activity (GO:0033131)3.15947220
50regulation of synaptic vesicle transport (GO:1902803)3.15676592
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.15110724
52glutamate secretion (GO:0014047)3.14040648
53positive regulation of protein autophosphorylation (GO:0031954)3.13722463
54hindbrain development (GO:0030902)3.13640186
55inositol phosphate catabolic process (GO:0071545)3.13159909
56neurotransmitter secretion (GO:0007269)3.12313376
57protein K6-linked ubiquitination (GO:0085020)3.10003383
58negative regulation of dendrite morphogenesis (GO:0050774)3.08449555
59transmission of nerve impulse (GO:0019226)3.06309060
60G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.05888292
61protein localization to microtubule (GO:0035372)3.05475090
62double-strand break repair via homologous recombination (GO:0000724)3.04945710
63protein localization to synapse (GO:0035418)3.03078969
64regulation of respiratory system process (GO:0044065)3.02790756
65recombinational repair (GO:0000725)3.02480889
66prostate gland growth (GO:0060736)3.00838566
67negative regulation of dendrite development (GO:2000171)3.00837435
68synaptic vesicle exocytosis (GO:0016079)3.00623011
69histone H3-K4 trimethylation (GO:0080182)2.99293450
70cytochrome complex assembly (GO:0017004)2.99178851
71maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.98759054
72positive regulation of synapse assembly (GO:0051965)2.93805740
73prenylation (GO:0097354)2.91463884
74protein prenylation (GO:0018342)2.91463884
75regulation of excitatory postsynaptic membrane potential (GO:0060079)2.88940270
76positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.88246435
77nuclear pore complex assembly (GO:0051292)2.87975528
78polyol catabolic process (GO:0046174)2.87706539
79phosphorylated carbohydrate dephosphorylation (GO:0046838)2.86964099
80inositol phosphate dephosphorylation (GO:0046855)2.86964099
81positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.86236082
82regulation of neuronal synaptic plasticity (GO:0048168)2.85717266
83regulation of synaptic transmission, GABAergic (GO:0032228)2.84365405
84tryptophan catabolic process (GO:0006569)2.83558117
85indole-containing compound catabolic process (GO:0042436)2.83558117
86indolalkylamine catabolic process (GO:0046218)2.83558117
87positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.82910067
88regulation of female receptivity (GO:0045924)2.82095892
89negative regulation of glycogen metabolic process (GO:0070874)2.81752962
90regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.80959824
91kynurenine metabolic process (GO:0070189)2.79716119
92DNA deamination (GO:0045006)2.79621568
93lactate metabolic process (GO:0006089)2.79389592
94regulation of synaptic transmission, glutamatergic (GO:0051966)2.78784804
95dendrite morphogenesis (GO:0048813)2.78528145
96long-term memory (GO:0007616)2.76704671
97regulation of long-term neuronal synaptic plasticity (GO:0048169)2.76602624
98regulation of meiosis I (GO:0060631)2.75653990
99glomerulus development (GO:0032835)2.75457131
100negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75313991
101fucose catabolic process (GO:0019317)2.74687740
102L-fucose metabolic process (GO:0042354)2.74687740
103L-fucose catabolic process (GO:0042355)2.74687740
104membrane depolarization during action potential (GO:0086010)2.73184850
105regulation of respiratory gaseous exchange (GO:0043576)2.72554281
106forebrain morphogenesis (GO:0048853)2.71791997
107regulation of synapse assembly (GO:0051963)2.70523917
108cerebral cortex radially oriented cell migration (GO:0021799)2.69755195
109RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.69636708
110neuron recognition (GO:0008038)2.69615682
111long-term synaptic potentiation (GO:0060291)2.69432163
112mechanosensory behavior (GO:0007638)2.69112292
113positive regulation of histone H3-K4 methylation (GO:0051571)2.68615388
114parental behavior (GO:0060746)2.67837083
115regulation of postsynaptic membrane potential (GO:0060078)2.67152403
116female mating behavior (GO:0060180)2.66702984
117synapse assembly (GO:0007416)2.64990540
118telomere maintenance via telomerase (GO:0007004)2.64974121
119interkinetic nuclear migration (GO:0022027)2.64237897
120regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.64107990
121positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.64107990
122cell differentiation in hindbrain (GO:0021533)2.63312279
123negative regulation of neurotransmitter secretion (GO:0046929)2.61965093
124negative regulation of neurotransmitter transport (GO:0051589)2.61360936
125neural tube formation (GO:0001841)2.60492464
126regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.60124072
127detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.59686494
128gamma-aminobutyric acid signaling pathway (GO:0007214)2.59617886
129nuclear pore organization (GO:0006999)2.58945514
130pituitary gland development (GO:0021983)2.58736099
131auditory behavior (GO:0031223)2.58510460
132cell differentiation involved in kidney development (GO:0061005)2.58505525
133positive regulation of synaptic transmission, GABAergic (GO:0032230)2.58400254
134neuronal ion channel clustering (GO:0045161)2.58152732
135regulation of gene silencing by RNA (GO:0060966)2.57604002
136regulation of posttranscriptional gene silencing (GO:0060147)2.57604002
137regulation of gene silencing by miRNA (GO:0060964)2.57604002
138histone exchange (GO:0043486)2.56902616
139spinal cord development (GO:0021510)2.56625964
140regulation of telomere maintenance (GO:0032204)2.55708450
141protein K11-linked deubiquitination (GO:0035871)2.55672746
142sulfation (GO:0051923)2.54629414
143cyclic nucleotide catabolic process (GO:0009214)2.54564337
144regulation of centriole replication (GO:0046599)2.53757821
145reciprocal DNA recombination (GO:0035825)2.53420127
146reciprocal meiotic recombination (GO:0007131)2.53420127
147cAMP catabolic process (GO:0006198)2.51092196
148regulation of neurotransmitter secretion (GO:0046928)2.50618929
149striatum development (GO:0021756)2.50089589
150positive regulation of mRNA catabolic process (GO:0061014)2.49944313
151neurotransmitter transport (GO:0006836)2.49338442
152indolalkylamine metabolic process (GO:0006586)2.48902201
153negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.47947542
154negative regulation of translation, ncRNA-mediated (GO:0040033)2.47947542
155regulation of translation, ncRNA-mediated (GO:0045974)2.47947542
156negative regulation of cell aging (GO:0090344)2.47413764
157innervation (GO:0060384)2.47331427
158regulation of mesoderm development (GO:2000380)2.47313364
159negative regulation of axon extension involved in axon guidance (GO:0048843)2.47291704
160synapse organization (GO:0050808)2.47069701
161establishment of nucleus localization (GO:0040023)2.46998658
162tryptophan metabolic process (GO:0006568)2.46370450
163negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.46110797
164behavioral defense response (GO:0002209)2.46092719
165behavioral fear response (GO:0001662)2.46092719
166cellular response to ATP (GO:0071318)2.45674729
167membrane depolarization (GO:0051899)2.44396278
168suckling behavior (GO:0001967)2.44152807
169positive regulation of mRNA processing (GO:0050685)2.43826653
170neuromuscular synaptic transmission (GO:0007274)2.43477216
171visual learning (GO:0008542)2.42183603
172protein localization to microtubule cytoskeleton (GO:0072698)2.41760366
173cellular protein complex localization (GO:0034629)2.41748786
174alternative mRNA splicing, via spliceosome (GO:0000380)2.41593588
175cell proliferation in forebrain (GO:0021846)2.41432676
176regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.41235955
177somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.40576164
178isotype switching (GO:0045190)2.40576164
179somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.40576164
180otic vesicle formation (GO:0030916)2.40464275
181embryonic epithelial tube formation (GO:0001838)2.40198936
182exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.39529199
183chromatin remodeling at centromere (GO:0031055)2.38927541
184positive regulation of mRNA metabolic process (GO:1903313)2.38775507
185somite development (GO:0061053)2.38126203
186atrial cardiac muscle cell action potential (GO:0086014)2.37996920
187positive regulation of chromosome segregation (GO:0051984)2.37721349
188positive regulation of glycoprotein biosynthetic process (GO:0010560)2.36975630
189DNA strand renaturation (GO:0000733)2.36844280
190cellular ketone body metabolic process (GO:0046950)2.36201897
191ketone body metabolic process (GO:1902224)2.35463804
192reflex (GO:0060004)2.35227513
193response to pheromone (GO:0019236)2.34108596

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.16450470
2GBX2_23144817_ChIP-Seq_PC3_Human4.28027112
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.58720648
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.56598270
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.79482363
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.57865262
7VDR_22108803_ChIP-Seq_LS180_Human2.51359162
8TAF15_26573619_Chip-Seq_HEK293_Human2.49454288
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32770649
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.32083935
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.26544580
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20688963
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.09828856
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.04256434
15RNF2_18974828_ChIP-Seq_MESCs_Mouse1.98088506
16EZH2_18974828_ChIP-Seq_MESCs_Mouse1.98088506
17SALL1_21062744_ChIP-ChIP_HESCs_Human1.95996494
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.95493307
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94767734
20* REST_21632747_ChIP-Seq_MESCs_Mouse1.93277798
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.92022231
22FUS_26573619_Chip-Seq_HEK293_Human1.91391378
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88155661
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.87561294
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87074039
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82517459
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82235568
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80382550
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79504340
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78946571
31SMAD4_21799915_ChIP-Seq_A2780_Human1.77132043
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.76770927
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.75356699
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73419366
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.72930309
36P300_19829295_ChIP-Seq_ESCs_Human1.72384202
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.71372693
38ELK1_19687146_ChIP-ChIP_HELA_Human1.70920329
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69089160
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68881297
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.67590417
42RNF2_27304074_Chip-Seq_NSC_Mouse1.65958750
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.61485426
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.60770694
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.60255397
46* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60053690
47STAT3_23295773_ChIP-Seq_U87_Human1.59519895
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57902145
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.56125447
50MTF2_20144788_ChIP-Seq_MESCs_Mouse1.52678295
51GABP_17652178_ChIP-ChIP_JURKAT_Human1.52265924
52BCAT_22108803_ChIP-Seq_LS180_Human1.51057745
53DROSHA_22980978_ChIP-Seq_HELA_Human1.50503409
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48837282
55TCF4_23295773_ChIP-Seq_U87_Human1.48691609
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47696651
57EWS_26573619_Chip-Seq_HEK293_Human1.47524212
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.46526567
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46288163
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.45488476
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43595735
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42233125
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.41798097
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.40895932
65MYC_18940864_ChIP-ChIP_HL60_Human1.40777283
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40366720
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39756497
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36733983
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36069544
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.35520181
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.35193873
72YAP1_20516196_ChIP-Seq_MESCs_Mouse1.34488912
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.34082187
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33558977
75* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33371215
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33338477
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33024484
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.31023112
79CBP_20019798_ChIP-Seq_JUKART_Human1.30841839
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30841839
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.30449460
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.29786753
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29546976
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29495571
85IGF1R_20145208_ChIP-Seq_DFB_Human1.29407589
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29156840
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28954544
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27179172
89AR_21572438_ChIP-Seq_LNCaP_Human1.26409217
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25755475
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25431439
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25396331
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25143028
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.25057387
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24955018
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24608824
97AR_25329375_ChIP-Seq_VCAP_Human1.23894769
98TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23073352
99RUNX2_22187159_ChIP-Seq_PCA_Human1.22980652
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.22964150
101ZNF274_21170338_ChIP-Seq_K562_Hela1.22644160
102AHR_22903824_ChIP-Seq_MCF-7_Human1.22243575
103SOX9_26525672_Chip-Seq_HEART_Mouse1.21664267
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20732908
105ER_23166858_ChIP-Seq_MCF-7_Human1.20498911
106RING1B_27294783_Chip-Seq_NPCs_Mouse1.19530119
107P53_22387025_ChIP-Seq_ESCs_Mouse1.19300615
108AR_19668381_ChIP-Seq_PC3_Human1.18816562
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18724287
110SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18687012
111CRX_20693478_ChIP-Seq_RETINA_Mouse1.18379544
112TCF4_22108803_ChIP-Seq_LS180_Human1.17914635
113E2F7_22180533_ChIP-Seq_HELA_Human1.16556103
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15619663
115VDR_23849224_ChIP-Seq_CD4+_Human1.15189333
116RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14689349
117TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14635651
118FLI1_21867929_ChIP-Seq_TH2_Mouse1.13994988
119PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13971263
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13531357
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13531357
122ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13324581
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12011090
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10014190
125P300_18555785_Chip-Seq_ESCs_Mouse1.09509993
126GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09242309
127SOX2_19829295_ChIP-Seq_ESCs_Human1.08866625
128NANOG_19829295_ChIP-Seq_ESCs_Human1.08866625
129FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08655537
130P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08614549
131PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06306500
132TP63_19390658_ChIP-ChIP_HaCaT_Human1.05808175
133OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05649270
134CMYC_18555785_Chip-Seq_ESCs_Mouse1.05047327
135* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04809866
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03930116
137SMAD4_21741376_ChIP-Seq_EPCs_Human1.03835487
138SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03281937
139TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03080694
140KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02779422
141TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02648125
142KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02301881
143SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01548838
144ISL1_27105846_Chip-Seq_CPCs_Mouse1.01178978
145SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00894712
146STAT3_18555785_Chip-Seq_ESCs_Mouse1.00396434
147EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99529777
148CDX2_22108803_ChIP-Seq_LS180_Human0.98646199

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.06928085
2MP0004859_abnormal_synaptic_plasticity3.56636543
3MP0003880_abnormal_central_pattern3.23905938
4MP0003635_abnormal_synaptic_transmissio2.73557663
5MP0010234_abnormal_vibrissa_follicle2.71185961
6MP0003122_maternal_imprinting2.61810066
7MP0005646_abnormal_pituitary_gland2.61713436
8MP0009745_abnormal_behavioral_response2.57414320
9MP0003121_genomic_imprinting2.56057588
10MP0003195_calcinosis2.52456333
11MP0009046_muscle_twitch2.40959916
12MP0006292_abnormal_olfactory_placode2.38202904
13MP0002063_abnormal_learning/memory/cond2.37563548
14MP0002102_abnormal_ear_morphology2.36298929
15MP0008057_abnormal_DNA_replication2.27767668
16MP0002064_seizures2.19326785
17MP0001188_hyperpigmentation2.15223767
18MP0001486_abnormal_startle_reflex2.12332891
19MP0004270_analgesia2.07627988
20MP0009780_abnormal_chondrocyte_physiolo2.00338519
21MP0002572_abnormal_emotion/affect_behav2.00309949
22MP0002822_catalepsy1.99135403
23MP0002272_abnormal_nervous_system1.90429168
24MP0002163_abnormal_gland_morphology1.89096616
25MP0010094_abnormal_chromosome_stability1.87306749
26MP0008058_abnormal_DNA_repair1.87299566
27MP0005248_abnormal_Harderian_gland1.83879024
28MP0002160_abnormal_reproductive_system1.81450559
29MP0002837_dystrophic_cardiac_calcinosis1.79722630
30MP0002067_abnormal_sensory_capabilities1.75785499
31MP0005423_abnormal_somatic_nervous1.65531199
32MP0000778_abnormal_nervous_system1.64800186
33MP0000631_abnormal_neuroendocrine_gland1.64746303
34MP0005389_reproductive_system_phenotype1.61601657
35MP0000427_abnormal_hair_cycle1.60765710
36MP0002557_abnormal_social/conspecific_i1.60764371
37MP0005379_endocrine/exocrine_gland_phen1.60339375
38MP0005386_behavior/neurological_phenoty1.58633257
39MP0004924_abnormal_behavior1.58633257
40MP0005174_abnormal_tail_pigmentation1.55618011
41MP0000566_synostosis1.54735808
42MP0008569_lethality_at_weaning1.52832847
43MP0005394_taste/olfaction_phenotype1.50415559
44MP0005499_abnormal_olfactory_system1.50415559
45MP0003283_abnormal_digestive_organ1.47564341
46MP0005171_absent_coat_pigmentation1.47369918
47MP0000569_abnormal_digit_pigmentation1.46593455
48MP0004885_abnormal_endolymph1.45003959
49MP0000372_irregular_coat_pigmentation1.44358469
50MP0003123_paternal_imprinting1.43794062
51MP0002184_abnormal_innervation1.41337856
52MP0010678_abnormal_skin_adnexa1.41246190
53MP0005645_abnormal_hypothalamus_physiol1.40337921
54MP0002638_abnormal_pupillary_reflex1.40329019
55MP0001944_abnormal_pancreas_morphology1.39758254
56MP0001968_abnormal_touch/_nociception1.39090435
57MP0002734_abnormal_mechanical_nocicepti1.33262536
58MP0000516_abnormal_urinary_system1.31541299
59MP0005367_renal/urinary_system_phenotyp1.31541299
60MP0003693_abnormal_embryo_hatching1.30951603
61MP0002928_abnormal_bile_duct1.30462058
62MP0005220_abnormal_exocrine_pancreas1.30110629
63MP0002882_abnormal_neuron_morphology1.29619899
64MP0001986_abnormal_taste_sensitivity1.28707454
65MP0000955_abnormal_spinal_cord1.28291907
66MP0005187_abnormal_penis_morphology1.27398356
67MP0006072_abnormal_retinal_apoptosis1.26714048
68MP0003890_abnormal_embryonic-extraembry1.26528833
69MP0003567_abnormal_fetal_cardiomyocyte1.24341131
70MP0000613_abnormal_salivary_gland1.23743199
71MP0001984_abnormal_olfaction1.22482299
72MP0001286_abnormal_eye_development1.22035086
73MP0002152_abnormal_brain_morphology1.21318353
74MP0001485_abnormal_pinna_reflex1.19086295
75MP0004811_abnormal_neuron_physiology1.18891123
76MP0008877_abnormal_DNA_methylation1.18542101
77MP0008789_abnormal_olfactory_epithelium1.18145623
78MP0001501_abnormal_sleep_pattern1.17941948
79MP0006276_abnormal_autonomic_nervous1.17681236
80MP0009250_abnormal_appendicular_skeleto1.17185443
81MP0004215_abnormal_myocardial_fiber1.13153763
82MP0004134_abnormal_chest_morphology1.12548312
83MP0003718_maternal_effect1.12534178
84MP0002736_abnormal_nociception_after1.12223164
85MP0005409_darkened_coat_color1.11426091
86MP0008872_abnormal_physiological_respon1.10533893
87MP0002234_abnormal_pharynx_morphology1.10214429
88MP0002735_abnormal_chemical_nociception1.08430981
89MP0002751_abnormal_autonomic_nervous1.08227858
90MP0001293_anophthalmia1.07749245
91MP0002066_abnormal_motor_capabilities/c1.06523457
92MP0001177_atelectasis1.06250686
93MP0003119_abnormal_digestive_system1.04720405
94MP0002138_abnormal_hepatobiliary_system1.04534101
95MP0000015_abnormal_ear_pigmentation1.03981701
96MP0003111_abnormal_nucleus_morphology1.03855202
97MP0002909_abnormal_adrenal_gland1.03260412
98MP0002938_white_spotting1.02210911
99MP0003385_abnormal_body_wall1.01367819
100MP0000049_abnormal_middle_ear1.00858387
101MP0003755_abnormal_palate_morphology1.00814895
102MP0001919_abnormal_reproductive_system1.00053470
103MP0002693_abnormal_pancreas_physiology0.99837269
104MP0010307_abnormal_tumor_latency0.98986826
105MP0009703_decreased_birth_body0.98586028
106MP0001440_abnormal_grooming_behavior0.98536021
107MP0004145_abnormal_muscle_electrophysio0.98391908
108MP0004142_abnormal_muscle_tone0.97360508
109MP0001502_abnormal_circadian_rhythm0.97131351
110MP0000647_abnormal_sebaceous_gland0.95149004
111MP0001963_abnormal_hearing_physiology0.94704805
112MP0003115_abnormal_respiratory_system0.94551101
113MP0003861_abnormal_nervous_system0.94509809
114MP0002876_abnormal_thyroid_physiology0.94077439
115MP0003136_yellow_coat_color0.93163885
116* MP0001145_abnormal_male_reproductive0.92767513
117MP0005551_abnormal_eye_electrophysiolog0.92755668
118MP0001529_abnormal_vocalization0.92496441
119MP0002009_preneoplasia0.91789846
120MP0004133_heterotaxia0.90970724
121* MP0002210_abnormal_sex_determination0.90277220
122MP0002095_abnormal_skin_pigmentation0.88589737
123MP0004085_abnormal_heartbeat0.87577690
124MP0000383_abnormal_hair_follicle0.87512893
125MP0003937_abnormal_limbs/digits/tail_de0.87227501
126MP0005084_abnormal_gallbladder_morpholo0.87017062
127* MP0000653_abnormal_sex_gland0.86858561
128MP0002752_abnormal_somatic_nervous0.86493324
129MP0003646_muscle_fatigue0.85991959
130MP0002127_abnormal_cardiovascular_syste0.84812900
131MP0004043_abnormal_pH_regulation0.84550382
132MP0005253_abnormal_eye_physiology0.81451228
133MP0002229_neurodegeneration0.80597205
134MP0002249_abnormal_larynx_morphology0.80529588
135MP0002081_perinatal_lethality0.80490614
136* MP0001929_abnormal_gametogenesis0.80219050
137MP0003879_abnormal_hair_cell0.79907268
138MP0000026_abnormal_inner_ear0.79498822
139MP0004197_abnormal_fetal_growth/weight/0.79190087
140MP0005195_abnormal_posterior_eye0.78689218
141MP0000428_abnormal_craniofacial_morphol0.77968230
142MP0000013_abnormal_adipose_tissue0.77518426
143MP0002233_abnormal_nose_morphology0.77477499
144MP0003935_abnormal_craniofacial_develop0.77012286
145MP0003938_abnormal_ear_development0.76772593
146* MP0002082_postnatal_lethality0.76389406
147* MP0010770_preweaning_lethality0.76389406
148MP0003943_abnormal_hepatobiliary_system0.75285567
149MP0003942_abnormal_urinary_system0.74043335
150MP0001324_abnormal_eye_pigmentation0.72725505
151MP0008007_abnormal_cellular_replicative0.72631319
152MP0005391_vision/eye_phenotype0.72314551
153MP0004957_abnormal_blastocyst_morpholog0.70900905
154MP0003077_abnormal_cell_cycle0.69822688

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.64557982
2Febrile seizures (HP:0002373)4.12876533
3Volvulus (HP:0002580)3.98594600
4Blue irides (HP:0000635)3.82402029
5Hypochromic microcytic anemia (HP:0004840)3.46161988
6Hepatoblastoma (HP:0002884)3.43079772
7Pancreatic cysts (HP:0001737)3.23300765
8Atonic seizures (HP:0010819)3.22020709
9Epileptic encephalopathy (HP:0200134)3.21554925
10Papillary thyroid carcinoma (HP:0002895)3.15014390
11Focal seizures (HP:0007359)3.08428588
12Pancreatic fibrosis (HP:0100732)3.04895356
13Protruding tongue (HP:0010808)3.00420798
14Bell-shaped thorax (HP:0001591)2.96494324
15Curly hair (HP:0002212)2.94086260
16Conjunctival hamartoma (HP:0100780)2.92616437
17Hamartoma of the eye (HP:0010568)2.91975569
18Methylmalonic acidemia (HP:0002912)2.80693595
19Congenital stationary night blindness (HP:0007642)2.77957029
20Hyperinsulinemic hypoglycemia (HP:0000825)2.77023470
21Hypothermia (HP:0002045)2.75467138
22True hermaphroditism (HP:0010459)2.74000833
23Hypoplasia of the fovea (HP:0007750)2.73934465
24Aplasia/Hypoplasia of the fovea (HP:0008060)2.73934465
25Abnormal hair whorl (HP:0010721)2.72083340
26High anterior hairline (HP:0009890)2.72062365
27Neoplasm of the adrenal cortex (HP:0100641)2.67969681
28Nephronophthisis (HP:0000090)2.66978781
29Abnormality of chromosome stability (HP:0003220)2.64240983
30Hyperventilation (HP:0002883)2.59319924
31Molar tooth sign on MRI (HP:0002419)2.59099527
32Abnormality of midbrain morphology (HP:0002418)2.59099527
33Anophthalmia (HP:0000528)2.58695311
34Broad-based gait (HP:0002136)2.58441505
35Gaze-evoked nystagmus (HP:0000640)2.57393095
36Pendular nystagmus (HP:0012043)2.52964810
37Myelomeningocele (HP:0002475)2.48309166
38Enlarged penis (HP:0000040)2.47428619
39Abnormality of the renal cortex (HP:0011035)2.47389197
40Intestinal atresia (HP:0011100)2.45919198
41Furrowed tongue (HP:0000221)2.43013658
42Progressive cerebellar ataxia (HP:0002073)2.40107454
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.38722074
44Thyroiditis (HP:0100646)2.38577956
45Hypoglycemic seizures (HP:0002173)2.35427439
46Meckel diverticulum (HP:0002245)2.31559014
47Pancreatic islet-cell hyperplasia (HP:0004510)2.30574453
48Excessive salivation (HP:0003781)2.28186485
49Drooling (HP:0002307)2.28186485
50Abnormality of the renal medulla (HP:0100957)2.28026992
51Occipital encephalocele (HP:0002085)2.27011189
52Cystic hygroma (HP:0000476)2.26440028
53Abnormality of the fovea (HP:0000493)2.25880612
54Medulloblastoma (HP:0002885)2.24739880
55Abnormality of vitamin B metabolism (HP:0004340)2.24307286
56Absent thumb (HP:0009777)2.23875655
57Abnormality of the ileum (HP:0001549)2.22226764
58Back pain (HP:0003418)2.22152068
59Cubitus valgus (HP:0002967)2.21337946
60Absent frontal sinuses (HP:0002688)2.20520383
61Hypoglycemic coma (HP:0001325)2.20428005
62Abnormal rod and cone electroretinograms (HP:0008323)2.19361190
63Bowel incontinence (HP:0002607)2.18364452
64Absence seizures (HP:0002121)2.18179406
65Depressed nasal tip (HP:0000437)2.17557702
66Meningioma (HP:0002858)2.17466948
67Narrow nasal bridge (HP:0000446)2.17065071
68Gait imbalance (HP:0002141)2.14544183
69Generalized tonic-clonic seizures (HP:0002069)2.13075546
70Stomach cancer (HP:0012126)2.11088634
71Nephrogenic diabetes insipidus (HP:0009806)2.10135353
72Dialeptic seizures (HP:0011146)2.08669797
73Optic nerve hypoplasia (HP:0000609)2.08477065
74Ketoacidosis (HP:0001993)2.06984775
75Astrocytoma (HP:0009592)2.05764306
76Abnormality of the astrocytes (HP:0100707)2.05764306
77Congenital primary aphakia (HP:0007707)2.05463574
78Myokymia (HP:0002411)2.05013336
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.04837121
80Chromsome breakage (HP:0040012)2.04432722
81Abnormality of the preputium (HP:0100587)2.03429211
82Ectopic kidney (HP:0000086)2.02680166
83Small hand (HP:0200055)2.02289472
84Abnormality of the phalanges of the 2nd finger (HP:0009541)2.02068611
85Abnormality of the labia minora (HP:0012880)2.01242649
86Long nose (HP:0003189)2.01230105
87Breast carcinoma (HP:0003002)2.00539120
88Abnormality of endocrine pancreas physiology (HP:0012093)2.00426095
89Abnormality of the pancreatic islet cells (HP:0006476)2.00426095
90Embryonal renal neoplasm (HP:0011794)1.98889562
91Congenital, generalized hypertrichosis (HP:0004540)1.98738218
92Visual hallucinations (HP:0002367)1.97189233
93Hemiparesis (HP:0001269)1.96912717
94Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95286746
95Thyroid carcinoma (HP:0002890)1.94105854
96Progressive macrocephaly (HP:0004481)1.94004738
97Hamartoma (HP:0010566)1.93714150
98Homocystinuria (HP:0002156)1.92786744
99Abnormality of homocysteine metabolism (HP:0010919)1.92786744
100Gastrointestinal atresia (HP:0002589)1.91943122
101Nephroblastoma (Wilms tumor) (HP:0002667)1.91937416
102Methylmalonic aciduria (HP:0012120)1.91440032
103Severe visual impairment (HP:0001141)1.90531995
104Subacute progressive viral hepatitis (HP:0006572)1.89905705
105Tubular atrophy (HP:0000092)1.89776693
106Medial flaring of the eyebrow (HP:0010747)1.88797647
107Abnormal large intestine physiology (HP:0012700)1.88291785
108Renal cortical cysts (HP:0000803)1.86256310
109Septo-optic dysplasia (HP:0100842)1.86204736
110Abolished electroretinogram (ERG) (HP:0000550)1.85784613
111Dysdiadochokinesis (HP:0002075)1.85453765
112Neoplasm of the adrenal gland (HP:0100631)1.84921748
113Wide intermamillary distance (HP:0006610)1.84881390
114Abnormal lung lobation (HP:0002101)1.83436482
115Hematochezia (HP:0002573)1.83364499
116Hypoplastic left heart (HP:0004383)1.82174876
117Pulmonic stenosis (HP:0001642)1.81926120
118Exotropia (HP:0000577)1.81683517
119Colon cancer (HP:0003003)1.80956534
120Radioulnar synostosis (HP:0002974)1.80155428
121Cystic liver disease (HP:0006706)1.79855527
122Macroorchidism (HP:0000053)1.79851745
123Abnormality of the vitamin B12 metabolism (HP:0004341)1.79732829
124Glioma (HP:0009733)1.79726882
125Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79013956
126Dandy-Walker malformation (HP:0001305)1.78591582
127Impaired vibration sensation in the lower limbs (HP:0002166)1.78409232
128Hypoplasia of the uterus (HP:0000013)1.77738311
129Sloping forehead (HP:0000340)1.77524544
130Gastroesophageal reflux (HP:0002020)1.77139250
131Clubbing of toes (HP:0100760)1.76936414
132Scrotal hypoplasia (HP:0000046)1.76754105
133Sclerocornea (HP:0000647)1.76692522
134Attenuation of retinal blood vessels (HP:0007843)1.76339700
135Abnormality of the nasal septum (HP:0000419)1.75900782
136Adenoma sebaceum (HP:0009720)1.74465998
137Angiofibromas (HP:0010615)1.74465998
138Embryonal neoplasm (HP:0002898)1.73836522
139Poor coordination (HP:0002370)1.73297309
140Aplasia involving bones of the upper limbs (HP:0009823)1.71860549
141Aplasia of the phalanges of the hand (HP:0009802)1.71860549
142Aplasia involving bones of the extremities (HP:0009825)1.71860549
143Hyperglycemia (HP:0003074)1.71818657
144Absent speech (HP:0001344)1.71031373
145Abnormal biliary tract morphology (HP:0012440)1.70739172
146Renal hypoplasia (HP:0000089)1.69009544
147Increased corneal curvature (HP:0100692)1.68842324
148Keratoconus (HP:0000563)1.68842324
149Fair hair (HP:0002286)1.68618926
150Urethral obstruction (HP:0000796)1.68540768
151Urinary bladder sphincter dysfunction (HP:0002839)1.68498370
152Truncal ataxia (HP:0002078)1.68422648
153Action tremor (HP:0002345)1.68075713
154Abnormality of salivation (HP:0100755)1.67513289
155Benign neoplasm of the central nervous system (HP:0100835)1.67304174
156Abnormal pancreas size (HP:0012094)1.67040971
157Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.66996221
158Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.66582551
159Degeneration of the lateral corticospinal tracts (HP:0002314)1.66582551
160Genetic anticipation (HP:0003743)1.66469841
161Tented upper lip vermilion (HP:0010804)1.66437810
162Aplasia/hypoplasia of the uterus (HP:0008684)1.66179442
163Deeply set eye (HP:0000490)1.66134730
164Vesicoureteral reflux (HP:0000076)1.65922647
165Narrow forehead (HP:0000341)1.65842756
166Abnormality of the pons (HP:0007361)1.65801819
167Genital tract atresia (HP:0001827)1.65799426
168Aqueductal stenosis (HP:0002410)1.65681712
169Abnormality of aspartate family amino acid metabolism (HP:0010899)1.65480341
170Abnormality of the duodenum (HP:0002246)1.65095050
171Decreased central vision (HP:0007663)1.64834866
172Large for gestational age (HP:0001520)1.64678508
173Pigmentary retinal degeneration (HP:0001146)1.63964365
174Impaired smooth pursuit (HP:0007772)1.63402128
175Abnormality of chromosome segregation (HP:0002916)1.63161204
176Vaginal atresia (HP:0000148)1.61925526
177Asymmetry of the thorax (HP:0001555)1.61747521
178Maternal diabetes (HP:0009800)1.61416812
179Epileptiform EEG discharges (HP:0011182)1.61311405
180Micropenis (HP:0000054)1.60168275
181Autism (HP:0000717)1.59625463
182Ectopic anus (HP:0004397)1.58308479
183Abnormality of incisor morphology (HP:0011063)1.57954159
184Inappropriate behavior (HP:0000719)1.57419659
185Amblyopia (HP:0000646)1.56854869
186Poor eye contact (HP:0000817)1.55861563
187Specific learning disability (HP:0001328)1.55142359

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.48182215
2CASK3.54841502
3AKT33.51894582
4MKNK23.50047150
5PRPF4B3.18815757
6ICK2.96894516
7SGK22.61963450
8ACVR1B2.59580069
9MKNK12.43917546
10GRK12.23452114
11WNK32.19107826
12MAP2K72.16688526
13EIF2AK32.13984423
14TAF12.08112443
15ERBB31.98253679
16SGK4941.97578888
17SGK2231.97578888
18EIF2AK11.96568449
19SGK31.92527263
20TNIK1.88773896
21BRD41.85014502
22MAPK131.79564600
23NEK61.77137385
24PINK11.74469630
25TRIM281.70623834
26PLK21.70174461
27LATS11.69511054
28YES11.69197469
29EPHA41.57613575
30MST41.55746288
31TNK21.52109891
32WEE11.46599830
33MAP3K41.46418335
34BRSK21.39068044
35VRK21.25089232
36PRKD31.24548557
37WNK11.22098321
38MINK11.19776656
39NTRK21.19264872
40CSNK1A1L1.18879220
41SRPK11.17239505
42SIK31.16863573
43CDC71.16782002
44MARK11.16734758
45PASK1.16406638
46CDC42BPA1.14090839
47STK38L1.13758850
48STK241.13148642
49STK31.11597392
50WNK41.11380552
51PLK41.08186172
52MAP4K21.06709684
53BUB11.04291710
54UHMK11.04255280
55TGFBR10.99706525
56SGK10.96310211
57PRKCH0.94349690
58NUAK10.92162154
59CSNK1G20.92071153
60DYRK1A0.90339514
61CDK30.89814551
62MAP2K40.89592719
63CDK120.88184793
64FGFR20.87646812
65PIK3CA0.87190899
66VRK10.86202056
67CDK80.83780689
68CSNK1G30.83718890
69TTK0.83467451
70RPS6KB10.81080111
71NLK0.80344170
72PRKCG0.80125135
73INSRR0.80037096
74PLK30.78802120
75PHKG20.78685357
76PHKG10.78685357
77BMPR1B0.78556481
78PLK10.75305072
79IRAK20.74839634
80MAPK70.73285687
81BMPR20.71920973
82STK110.71197345
83CCNB10.71098676
84PTK2B0.69030734
85CDK50.67216058
86CSNK1G10.64871774
87CAMK40.64693234
88EIF2AK20.63539234
89RPS6KA20.62573694
90TSSK60.62230936
91FGFR10.60450927
92ZAK0.58877796
93FLT30.57537286
94CAMKK10.57362823
95ALK0.57257303
96RPS6KA30.56072447
97DAPK20.55553414
98PAK30.55173019
99CAMK2A0.54902891
100FRK0.54818881
101STK160.54067449
102PRKG10.51635613
103ATR0.51179784
104CHEK20.50985166
105CAMK2B0.49622322
106GSK3B0.49589552
107KSR10.49244750
108MAPK100.48839954
109CAMKK20.48290897
110PRKCE0.48083634
111MAPK140.46381663
112CSNK1A10.46300415
113MAP3K120.45413026
114HIPK20.44097083
115TLK10.43774056
116NEK20.43225090
117PRKCB0.42231605
118FER0.42189116
119DAPK10.41513955
120MELK0.41505585
121CSNK1D0.41140502
122BRAF0.40641771
123CDK10.40460439
124ADRBK20.40344473
125RPS6KC10.40232488
126RPS6KL10.40232488
127PRKDC0.40185100
128BCR0.39941528
129OXSR10.39794749
130PNCK0.38763440
131CDK20.38143849
132CHEK10.37723692
133FGFR30.37172766
134STK390.37114871
135GRK70.37104703
136ATM0.36916247
137CDK190.36684043
138MAPKAPK50.35456599
139RPS6KB20.34484967
140ADRBK10.33282977
141PDK20.33074438
142CAMK1G0.32401489
143BRSK10.31455540
144CSNK1E0.31308935
145PRKAA10.31209395
146RPS6KA60.31121203
147TAOK10.29969122
148NEK10.27362114
149PRKCI0.24958228
150PRKAA20.24732246

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.93511391
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.79093145
3Homologous recombination_Homo sapiens_hsa034403.11925368
4Protein export_Homo sapiens_hsa030603.00734770
5Caffeine metabolism_Homo sapiens_hsa002322.93058471
6Long-term potentiation_Homo sapiens_hsa047202.79475589
7Non-homologous end-joining_Homo sapiens_hsa034502.74247998
8Circadian entrainment_Homo sapiens_hsa047132.65621427
9Glutamatergic synapse_Homo sapiens_hsa047242.53180220
10Basal transcription factors_Homo sapiens_hsa030222.48862853
11GABAergic synapse_Homo sapiens_hsa047272.43816622
12Amphetamine addiction_Homo sapiens_hsa050312.39001277
13Morphine addiction_Homo sapiens_hsa050322.28072887
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.24380193
15Olfactory transduction_Homo sapiens_hsa047402.22084783
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.16889894
17Selenocompound metabolism_Homo sapiens_hsa004502.11561086
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.10882957
19Synaptic vesicle cycle_Homo sapiens_hsa047212.02736012
20Endometrial cancer_Homo sapiens_hsa052132.00901856
21Taste transduction_Homo sapiens_hsa047421.95767913
22Butanoate metabolism_Homo sapiens_hsa006501.92511771
23One carbon pool by folate_Homo sapiens_hsa006701.88424528
24Dopaminergic synapse_Homo sapiens_hsa047281.84440786
25Long-term depression_Homo sapiens_hsa047301.82996076
26Insulin secretion_Homo sapiens_hsa049111.81434808
27RNA transport_Homo sapiens_hsa030131.81338902
28Cocaine addiction_Homo sapiens_hsa050301.77374234
29RNA polymerase_Homo sapiens_hsa030201.72390461
30Nitrogen metabolism_Homo sapiens_hsa009101.72239679
31Dorso-ventral axis formation_Homo sapiens_hsa043201.59102332
32ErbB signaling pathway_Homo sapiens_hsa040121.58482664
33Salivary secretion_Homo sapiens_hsa049701.57053863
34Cholinergic synapse_Homo sapiens_hsa047251.55423922
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54374088
36Glioma_Homo sapiens_hsa052141.53661273
37Propanoate metabolism_Homo sapiens_hsa006401.50806393
38Vitamin B6 metabolism_Homo sapiens_hsa007501.49895510
39Calcium signaling pathway_Homo sapiens_hsa040201.45943670
40Phototransduction_Homo sapiens_hsa047441.37388963
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36513671
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36348539
43Serotonergic synapse_Homo sapiens_hsa047261.36240857
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36099611
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35431152
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33275041
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.32025182
48Mismatch repair_Homo sapiens_hsa034301.28381701
49Renin secretion_Homo sapiens_hsa049241.27620394
50Axon guidance_Homo sapiens_hsa043601.26147378
51Spliceosome_Homo sapiens_hsa030401.25518192
52mRNA surveillance pathway_Homo sapiens_hsa030151.24926103
53Gap junction_Homo sapiens_hsa045401.22501809
54Oxytocin signaling pathway_Homo sapiens_hsa049211.21567772
55cAMP signaling pathway_Homo sapiens_hsa040241.20612950
56GnRH signaling pathway_Homo sapiens_hsa049121.20400022
57Tryptophan metabolism_Homo sapiens_hsa003801.17761625
58Type II diabetes mellitus_Homo sapiens_hsa049301.17568623
59Nucleotide excision repair_Homo sapiens_hsa034201.17138123
60Gastric acid secretion_Homo sapiens_hsa049711.16923389
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16553542
62Non-small cell lung cancer_Homo sapiens_hsa052231.14862246
63Basal cell carcinoma_Homo sapiens_hsa052171.13456282
64Estrogen signaling pathway_Homo sapiens_hsa049151.08926980
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06904620
66Wnt signaling pathway_Homo sapiens_hsa043101.06164150
67cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04730605
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03415151
69Oxidative phosphorylation_Homo sapiens_hsa001901.02843846
70Circadian rhythm_Homo sapiens_hsa047101.01780199
71Ether lipid metabolism_Homo sapiens_hsa005650.99971565
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97579125
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95426797
74Melanogenesis_Homo sapiens_hsa049160.95249529
75Alcoholism_Homo sapiens_hsa050340.94047211
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93728889
77Vitamin digestion and absorption_Homo sapiens_hsa049770.92925174
78p53 signaling pathway_Homo sapiens_hsa041150.91702765
79Linoleic acid metabolism_Homo sapiens_hsa005910.91217605
80Cell cycle_Homo sapiens_hsa041100.90927513
81Oocyte meiosis_Homo sapiens_hsa041140.90155678
82Choline metabolism in cancer_Homo sapiens_hsa052310.89689347
83TGF-beta signaling pathway_Homo sapiens_hsa043500.89663929
84Purine metabolism_Homo sapiens_hsa002300.88069290
85Prostate cancer_Homo sapiens_hsa052150.85727653
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84869451
87MAPK signaling pathway_Homo sapiens_hsa040100.84347666
88Proteasome_Homo sapiens_hsa030500.83821981
89Colorectal cancer_Homo sapiens_hsa052100.83332211
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82559325
91Hedgehog signaling pathway_Homo sapiens_hsa043400.81783556
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.81425527
93Folate biosynthesis_Homo sapiens_hsa007900.79881209
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79365155
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.79303409
96Regulation of autophagy_Homo sapiens_hsa041400.78678871
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.77572458
98FoxO signaling pathway_Homo sapiens_hsa040680.75775539
99Lysine degradation_Homo sapiens_hsa003100.75540612
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75423951
101mTOR signaling pathway_Homo sapiens_hsa041500.75123573
102Insulin signaling pathway_Homo sapiens_hsa049100.74175391
103DNA replication_Homo sapiens_hsa030300.73611794
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73441487
105Prolactin signaling pathway_Homo sapiens_hsa049170.73382601
106Collecting duct acid secretion_Homo sapiens_hsa049660.72968334
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72213098
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71902846
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71376925
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71024459
111Ras signaling pathway_Homo sapiens_hsa040140.69645032
112Renal cell carcinoma_Homo sapiens_hsa052110.69457480
113Inositol phosphate metabolism_Homo sapiens_hsa005620.68585196
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67740587
115Dilated cardiomyopathy_Homo sapiens_hsa054140.66941730
116Glucagon signaling pathway_Homo sapiens_hsa049220.66274230
117Parkinsons disease_Homo sapiens_hsa050120.65702723
118Melanoma_Homo sapiens_hsa052180.64167189
119Acute myeloid leukemia_Homo sapiens_hsa052210.63861522
120Pancreatic secretion_Homo sapiens_hsa049720.63508299
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62322618
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61341138
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60890469
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59294179
125Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58048055
126Peroxisome_Homo sapiens_hsa041460.56955317
127Hippo signaling pathway_Homo sapiens_hsa043900.56828219
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56281475
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55833711
130RNA degradation_Homo sapiens_hsa030180.55804050
131Thyroid hormone synthesis_Homo sapiens_hsa049180.55111300
132ABC transporters_Homo sapiens_hsa020100.55106722
133MicroRNAs in cancer_Homo sapiens_hsa052060.52589734
134Rap1 signaling pathway_Homo sapiens_hsa040150.52072130
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51939194
136Retinol metabolism_Homo sapiens_hsa008300.51683833
137Huntingtons disease_Homo sapiens_hsa050160.50503482
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49717808
139Glycerolipid metabolism_Homo sapiens_hsa005610.49325841
140Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47939923
141Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45276238
142Vibrio cholerae infection_Homo sapiens_hsa051100.44780635
143Cysteine and methionine metabolism_Homo sapiens_hsa002700.44599110
144Chemical carcinogenesis_Homo sapiens_hsa052040.42982913
145Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41964995
146Sulfur metabolism_Homo sapiens_hsa009200.41432577
147Chronic myeloid leukemia_Homo sapiens_hsa052200.41236851
148Steroid biosynthesis_Homo sapiens_hsa001000.40311448
149Fanconi anemia pathway_Homo sapiens_hsa034600.39045863
150Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38345541
151Ovarian steroidogenesis_Homo sapiens_hsa049130.37912266
152Metabolic pathways_Homo sapiens_hsa011000.36225780
153Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35212741
154Pyrimidine metabolism_Homo sapiens_hsa002400.34656386
155Alzheimers disease_Homo sapiens_hsa050100.31900076
156Ribosome_Homo sapiens_hsa030100.31374804
157Tight junction_Homo sapiens_hsa045300.30747948

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