TIAM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.12590634
2vocalization behavior (GO:0071625)4.81002710
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.77221026
4regulation of glutamate receptor signaling pathway (GO:1900449)4.71326956
5regulation of synapse structural plasticity (GO:0051823)4.68371838
6behavioral response to nicotine (GO:0035095)4.67297220
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.60386400
8synaptic vesicle docking involved in exocytosis (GO:0016081)4.57283577
9neuron cell-cell adhesion (GO:0007158)4.44090779
10locomotory exploration behavior (GO:0035641)4.21309286
11cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.18308098
12cartilage condensation (GO:0001502)4.13258878
13cell aggregation (GO:0098743)4.13258878
14limb bud formation (GO:0060174)4.11168245
15regulation of synaptic vesicle exocytosis (GO:2000300)4.11039821
16neurotransmitter-gated ion channel clustering (GO:0072578)4.06914745
17glutamate secretion (GO:0014047)4.03069752
18positive regulation of synapse maturation (GO:0090129)3.96405496
19chondrocyte development (GO:0002063)3.95928953
20synaptic vesicle exocytosis (GO:0016079)3.80766407
21gamma-aminobutyric acid transport (GO:0015812)3.78573255
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.76938470
23protein localization to synapse (GO:0035418)3.74193740
24regulation of synaptic vesicle transport (GO:1902803)3.73186310
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.73152396
26regulation of long-term neuronal synaptic plasticity (GO:0048169)3.71450588
27synaptic transmission, glutamatergic (GO:0035249)3.69302590
28synaptic vesicle maturation (GO:0016188)3.69036400
29fucose catabolic process (GO:0019317)3.68874426
30L-fucose metabolic process (GO:0042354)3.68874426
31L-fucose catabolic process (GO:0042355)3.68874426
32central nervous system projection neuron axonogenesis (GO:0021952)3.68158751
33ionotropic glutamate receptor signaling pathway (GO:0035235)3.68138197
34regulation of dendritic spine morphogenesis (GO:0061001)3.66521512
35regulation of neuronal synaptic plasticity (GO:0048168)3.60926235
36axonal fasciculation (GO:0007413)3.57053902
37behavioral response to ethanol (GO:0048149)3.55554036
38neuron-neuron synaptic transmission (GO:0007270)3.48590037
39positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.48496638
40cell migration in hindbrain (GO:0021535)3.48108280
41positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.47557357
42substrate-independent telencephalic tangential migration (GO:0021826)3.45098462
43substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.45098462
44prepulse inhibition (GO:0060134)3.44228305
45adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.41618627
46cerebral cortex radially oriented cell migration (GO:0021799)3.39268185
47negative regulation of dendrite development (GO:2000171)3.38685648
48neurotransmitter secretion (GO:0007269)3.37378040
49C4-dicarboxylate transport (GO:0015740)3.33673952
50layer formation in cerebral cortex (GO:0021819)3.32740280
51postsynaptic membrane organization (GO:0001941)3.31261909
52neuron recognition (GO:0008038)3.30560143
53protein polyglutamylation (GO:0018095)3.29798404
54detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.29126297
55exploration behavior (GO:0035640)3.28112762
56transmission of nerve impulse (GO:0019226)3.27850346
57dopamine receptor signaling pathway (GO:0007212)3.25851048
58glutamate receptor signaling pathway (GO:0007215)3.23837777
59dendrite morphogenesis (GO:0048813)3.21060825
60regulation of excitatory postsynaptic membrane potential (GO:0060079)3.20604354
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.20183641
62protein K11-linked deubiquitination (GO:0035871)3.20167348
63negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.17620706
64negative regulation of translation, ncRNA-mediated (GO:0040033)3.17620706
65regulation of translation, ncRNA-mediated (GO:0045974)3.17620706
66dendritic spine morphogenesis (GO:0060997)3.15077337
67DNA double-strand break processing (GO:0000729)3.12133770
68G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.11318174
69cerebellar granule cell differentiation (GO:0021707)3.10619337
70regulation of synapse maturation (GO:0090128)3.10011714
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.05506477
72presynaptic membrane assembly (GO:0097105)3.05426993
73negative regulation of sodium ion transport (GO:0010766)3.04796848
74regulation of synaptic plasticity (GO:0048167)3.04009835
75G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.02605337
76proline transport (GO:0015824)3.02593582
77chondrocyte proliferation (GO:0035988)3.02250857
78pyrimidine nucleobase catabolic process (GO:0006208)3.01886504
79behavioral defense response (GO:0002209)3.01730311
80behavioral fear response (GO:0001662)3.01730311
81neuronal action potential propagation (GO:0019227)2.99305807
82central nervous system neuron axonogenesis (GO:0021955)2.99026489
83collagen fibril organization (GO:0030199)2.98743889
84negative regulation of synaptic transmission, GABAergic (GO:0032229)2.98303627
85glial cell proliferation (GO:0014009)2.97567086
86regulation of dendritic spine development (GO:0060998)2.97394562
87startle response (GO:0001964)2.96741588
88regulation of postsynaptic membrane potential (GO:0060078)2.93715018
89negative regulation of dendrite morphogenesis (GO:0050774)2.92600351
90long-term synaptic potentiation (GO:0060291)2.90069709
91membrane depolarization during action potential (GO:0086010)2.89987320
92regulation of female receptivity (GO:0045924)2.89781765
93regulation of neurotransmitter secretion (GO:0046928)2.89290411
94long-term memory (GO:0007616)2.88271010
95response to pheromone (GO:0019236)2.88151940
96cAMP catabolic process (GO:0006198)2.86352891
97notochord development (GO:0030903)2.85735361
98retinal cone cell development (GO:0046549)2.83310436
99auditory behavior (GO:0031223)2.83305228
100positive regulation of neurotransmitter secretion (GO:0001956)2.82133153
101presynaptic membrane organization (GO:0097090)2.82027609
102atrial cardiac muscle cell action potential (GO:0086014)2.81655518
103neuronal action potential (GO:0019228)2.81121359
104regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.79020078
105negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.77955783
106regulation of neurotransmitter transport (GO:0051588)2.77827460
107fear response (GO:0042596)2.75594470
108mechanosensory behavior (GO:0007638)2.75422271
109positive regulation of membrane potential (GO:0045838)2.75402613
110negative regulation of hormone metabolic process (GO:0032351)2.74944629
111negative regulation of hormone biosynthetic process (GO:0032353)2.74944629
112negative regulation of astrocyte differentiation (GO:0048712)2.74807753
113behavioral response to cocaine (GO:0048148)2.72554359
114positive regulation of neurotransmitter transport (GO:0051590)2.72433730
115kidney morphogenesis (GO:0060993)2.72328750
116inner ear receptor stereocilium organization (GO:0060122)2.71982250
117positive regulation of dendritic spine morphogenesis (GO:0061003)2.71623524
118neuromuscular process controlling balance (GO:0050885)2.70531885
119somite development (GO:0061053)2.67929147
120establishment of nucleus localization (GO:0040023)2.66750224
121replacement ossification (GO:0036075)2.66653618
122endochondral ossification (GO:0001958)2.66653618
123negative regulation of cytosolic calcium ion concentration (GO:0051481)2.66093319
124nucleobase catabolic process (GO:0046113)2.63835644
125positive regulation of axon extension (GO:0045773)2.62818185
126synapse assembly (GO:0007416)2.61252789
127positive regulation of fibroblast migration (GO:0010763)2.60495678
128visual learning (GO:0008542)2.59745815
129serotonin receptor signaling pathway (GO:0007210)2.59522517
130innervation (GO:0060384)2.59344597
131regulation of neurotransmitter uptake (GO:0051580)2.59284271
132regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.59017549
133auditory receptor cell stereocilium organization (GO:0060088)2.57833074
134gamma-aminobutyric acid signaling pathway (GO:0007214)2.57175714
135detection of light stimulus involved in visual perception (GO:0050908)2.55785830
136detection of light stimulus involved in sensory perception (GO:0050962)2.55785830
137kynurenine metabolic process (GO:0070189)2.55307237
138positive regulation of cardiac muscle cell differentiation (GO:2000727)2.54061436
139regulation of action potential (GO:0098900)2.53696233
140primary amino compound metabolic process (GO:1901160)2.52478177
141axoneme assembly (GO:0035082)2.52234922
142indole-containing compound catabolic process (GO:0042436)2.51758401
143indolalkylamine catabolic process (GO:0046218)2.51758401
144tryptophan catabolic process (GO:0006569)2.51758401
145neuromuscular synaptic transmission (GO:0007274)2.49604021
146action potential (GO:0001508)2.47641700
147regulation of sarcomere organization (GO:0060297)2.47580323
148adaptation of signaling pathway (GO:0023058)2.47057404
149glycosphingolipid biosynthetic process (GO:0006688)2.45189890
150reflex (GO:0060004)2.43959006
151detection of mechanical stimulus involved in sensory perception (GO:0050974)2.43901091
152positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.42876472
153replication fork processing (GO:0031297)2.42496944
154neural tube formation (GO:0001841)2.42315436
155RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.40253586
156regulation of meiosis I (GO:0060631)2.39148413
157cochlea development (GO:0090102)2.37630510
158hindbrain development (GO:0030902)2.37423569
159indolalkylamine metabolic process (GO:0006586)2.37229814
160membrane depolarization (GO:0051899)2.36851041
161negative regulation of DNA-dependent DNA replication (GO:2000104)2.35670404

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.44401801
2GBX2_23144817_ChIP-Seq_PC3_Human3.51281810
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.82860049
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64449330
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.59323170
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57852260
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57852260
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.56819144
9AR_21572438_ChIP-Seq_LNCaP_Human2.54625327
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49417128
11VDR_22108803_ChIP-Seq_LS180_Human2.44147843
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.43634262
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36060457
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35962983
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.26947350
16* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23326809
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19817308
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.17604280
19* EED_16625203_ChIP-ChIP_MESCs_Mouse2.16002368
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.09467585
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.08440917
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06539729
23* RNF2_27304074_Chip-Seq_ESCs_Mouse2.06403652
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01190207
25DROSHA_22980978_ChIP-Seq_HELA_Human1.94084099
26EWS_26573619_Chip-Seq_HEK293_Human1.91696167
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88546437
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86981955
29REST_21632747_ChIP-Seq_MESCs_Mouse1.86000207
30* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85842633
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.83983061
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78711134
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73577364
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72566256
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.72435092
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69608416
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68744496
38* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.67400833
39SMAD4_21799915_ChIP-Seq_A2780_Human1.64566336
40ER_23166858_ChIP-Seq_MCF-7_Human1.61954970
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61278896
42BCAT_22108803_ChIP-Seq_LS180_Human1.58597975
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58237797
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.56327873
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.55828373
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54720108
47CBP_20019798_ChIP-Seq_JUKART_Human1.54720108
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54555669
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54259574
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53763155
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47478701
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46843877
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46619755
54TP53_16413492_ChIP-PET_HCT116_Human1.45617865
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44659162
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43977278
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.43155875
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.43075412
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42104497
60* P300_19829295_ChIP-Seq_ESCs_Human1.41004781
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.40118212
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.39000785
63AR_25329375_ChIP-Seq_VCAP_Human1.36740545
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35114200
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34919048
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31716530
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.31574477
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31556131
69* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30885005
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30621524
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29195455
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29096476
73STAT3_23295773_ChIP-Seq_U87_Human1.29090033
74* TCF4_22108803_ChIP-Seq_LS180_Human1.28315535
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27924079
76TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26387317
77* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25838772
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25136428
79TRIM28_21343339_ChIP-Seq_HEK293_Human1.24820554
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24609758
81RXR_22108803_ChIP-Seq_LS180_Human1.24155189
82TP53_18474530_ChIP-ChIP_U2OS_Human1.23933917
83* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23601774
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.22770916
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.22733515
86TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.22511254
87* AR_19668381_ChIP-Seq_PC3_Human1.21451284
88POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21301890
89RNF2_27304074_Chip-Seq_NSC_Mouse1.21017602
90TAF15_26573619_Chip-Seq_HEK293_Human1.20933518
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20021890
92RING1B_27294783_Chip-Seq_ESCs_Mouse1.19911398
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19267440
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.19255501
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17773182
96* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17400953
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17296179
98SOX2_19829295_ChIP-Seq_ESCs_Human1.16806918
99NANOG_19829295_ChIP-Seq_ESCs_Human1.16806918
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16324515
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15275343
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15260731
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15213414
104TP53_22573176_ChIP-Seq_HFKS_Human1.14842222
105* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14173945
106* SMAD4_21741376_ChIP-Seq_EPCs_Human1.13825940
107P53_22387025_ChIP-Seq_ESCs_Mouse1.12936340
108ZNF274_21170338_ChIP-Seq_K562_Hela1.12043433
109* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11112463
110* RING1B_27294783_Chip-Seq_NPCs_Mouse1.10632525
111ARNT_22903824_ChIP-Seq_MCF-7_Human1.10404888
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10166241
113TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09993720
114JUN_21703547_ChIP-Seq_K562_Human1.09617147
115TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09318160
116NOTCH1_21737748_ChIP-Seq_TLL_Human1.09226937
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09212913
118KDM2B_26808549_Chip-Seq_REH_Human1.08867962
119* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08618023
120* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08618023
121BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08134705
122* TCF4_23295773_ChIP-Seq_U87_Human1.07890622
123P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07883396
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06602288
125E2F1_18555785_Chip-Seq_ESCs_Mouse1.06486591
126SMAD3_21741376_ChIP-Seq_HESCs_Human1.05963250
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05408693
128* RUNX2_22187159_ChIP-Seq_PCA_Human1.05340680
129* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04886334
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04654573
131PRDM14_20953172_ChIP-Seq_ESCs_Human1.03381598
132HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03176093
133CMYC_18555785_Chip-Seq_ESCs_Mouse1.02606155
134POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02416361
135CRX_20693478_ChIP-Seq_RETINA_Mouse1.02297059
136KDM2B_26808549_Chip-Seq_K562_Human1.01362599
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01289779
138NANOG_18555785_Chip-Seq_ESCs_Mouse1.00592012
139CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99775442
140* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98345469
141* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98345469
142* SMAD4_21741376_ChIP-Seq_HESCs_Human0.97224227
143AHR_22903824_ChIP-Seq_MCF-7_Human0.95998259
144FUS_26573619_Chip-Seq_HEK293_Human0.95574676
145TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95436253
146IGF1R_20145208_ChIP-Seq_DFB_Human0.94506504

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.45730721
2MP0002822_catalepsy4.64861388
3MP0003635_abnormal_synaptic_transmissio3.30514545
4MP0004270_analgesia3.23241816
5MP0003880_abnormal_central_pattern3.12174693
6MP0002063_abnormal_learning/memory/cond2.93572880
7MP0009745_abnormal_behavioral_response2.74849227
8MP0005423_abnormal_somatic_nervous2.69936854
9MP0009780_abnormal_chondrocyte_physiolo2.65637479
10MP0003787_abnormal_imprinting2.64498233
11MP0008877_abnormal_DNA_methylation2.59293970
12MP0001968_abnormal_touch/_nociception2.30134882
13MP0009250_abnormal_appendicular_skeleto2.26569043
14MP0002572_abnormal_emotion/affect_behav2.26410307
15MP0002064_seizures2.22826015
16MP0005551_abnormal_eye_electrophysiolog2.09044390
17MP0004134_abnormal_chest_morphology2.08529408
18MP0006292_abnormal_olfactory_placode2.05796777
19MP0005503_abnormal_tendon_morphology2.00814581
20MP0002736_abnormal_nociception_after1.99548757
21MP0006072_abnormal_retinal_apoptosis1.97525233
22MP0009046_muscle_twitch1.97394828
23MP0002102_abnormal_ear_morphology1.92227642
24MP0003283_abnormal_digestive_organ1.90834753
25MP0000778_abnormal_nervous_system1.90324688
26MP0002734_abnormal_mechanical_nocicepti1.89042865
27MP0002735_abnormal_chemical_nociception1.87541805
28MP0002282_abnormal_trachea_morphology1.83463003
29MP0000163_abnormal_cartilage_morphology1.76366957
30MP0002909_abnormal_adrenal_gland1.68644495
31MP0008872_abnormal_physiological_respon1.68392232
32MP0001486_abnormal_startle_reflex1.66747109
33MP0005253_abnormal_eye_physiology1.66644517
34MP0001299_abnormal_eye_distance/1.63591918
35MP0003755_abnormal_palate_morphology1.61065430
36MP0000751_myopathy1.61005706
37MP0002184_abnormal_innervation1.57016575
38MP0003646_muscle_fatigue1.56834730
39MP0001485_abnormal_pinna_reflex1.53976671
40MP0002638_abnormal_pupillary_reflex1.52609538
41MP0003123_paternal_imprinting1.51332344
42MP0005646_abnormal_pituitary_gland1.51086624
43MP0004811_abnormal_neuron_physiology1.48104143
44MP0002272_abnormal_nervous_system1.47358615
45MP0001177_atelectasis1.47296218
46MP0002938_white_spotting1.44771124
47MP0004043_abnormal_pH_regulation1.44552662
48MP0002115_abnormal_skeleton_extremities1.43950164
49MP0000049_abnormal_middle_ear1.43776558
50MP0002249_abnormal_larynx_morphology1.43684732
51MP0002896_abnormal_bone_mineralization1.42678478
52MP0000427_abnormal_hair_cycle1.42527086
53MP0005386_behavior/neurological_phenoty1.41069981
54MP0004924_abnormal_behavior1.41069981
55MP0001986_abnormal_taste_sensitivity1.39209312
56MP0002557_abnormal_social/conspecific_i1.39044900
57MP0000569_abnormal_digit_pigmentation1.34343448
58MP0004145_abnormal_muscle_electrophysio1.33228243
59MP0002089_abnormal_postnatal_growth/wei1.32939187
60MP0003195_calcinosis1.32596724
61MP0009384_cardiac_valve_regurgitation1.32499271
62MP0002933_joint_inflammation1.31949596
63MP0004142_abnormal_muscle_tone1.30851411
64MP0004742_abnormal_vestibular_system1.29360477
65MP0001970_abnormal_pain_threshold1.29003616
66MP0001188_hyperpigmentation1.26794200
67MP0002733_abnormal_thermal_nociception1.26737783
68MP0002751_abnormal_autonomic_nervous1.26022756
69MP0002116_abnormal_craniofacial_bone1.25322608
70MP0000955_abnormal_spinal_cord1.22623787
71MP0002067_abnormal_sensory_capabilities1.21524065
72MP0003385_abnormal_body_wall1.18749524
73MP0003890_abnormal_embryonic-extraembry1.18559133
74MP0003136_yellow_coat_color1.18546018
75MP0001270_distended_abdomen1.17926313
76MP0001984_abnormal_olfaction1.14864254
77MP0005174_abnormal_tail_pigmentation1.14820096
78MP0004858_abnormal_nervous_system1.12995357
79MP0004885_abnormal_endolymph1.11335227
80MP0002113_abnormal_skeleton_development1.10907032
81MP0001529_abnormal_vocalization1.08653831
82MP0001501_abnormal_sleep_pattern1.07899600
83MP0001440_abnormal_grooming_behavior1.07422211
84MP0004147_increased_porphyrin_level1.07026330
85MP0002752_abnormal_somatic_nervous1.06743981
86MP0001293_anophthalmia1.05649295
87MP0003879_abnormal_hair_cell1.05154420
88MP0000762_abnormal_tongue_morphology1.04268751
89MP0002876_abnormal_thyroid_physiology1.03606788
90MP0002109_abnormal_limb_morphology1.02986948
91MP0005508_abnormal_skeleton_morphology1.02046734
92MP0003705_abnormal_hypodermis_morpholog1.01434763
93MP0002152_abnormal_brain_morphology1.01214045
94MP0003935_abnormal_craniofacial_develop1.00371000
95MP0002066_abnormal_motor_capabilities/c1.00282833
96MP0003718_maternal_effect0.99649017
97MP0000372_irregular_coat_pigmentation0.99410671
98MP0002882_abnormal_neuron_morphology0.98611954
99MP0008438_abnormal_cutaneous_collagen0.98431095
100MP0003119_abnormal_digestive_system0.97913243
101MP0008569_lethality_at_weaning0.97758806
102MP0005187_abnormal_penis_morphology0.97390973
103MP0002234_abnormal_pharynx_morphology0.97250952
104MP0003633_abnormal_nervous_system0.97020449
105MP0004215_abnormal_myocardial_fiber0.96606754
106MP0003121_genomic_imprinting0.95341196
107MP0002233_abnormal_nose_morphology0.92908003
108MP0005195_abnormal_posterior_eye0.92795743
109MP0005645_abnormal_hypothalamus_physiol0.92456735
110MP0004133_heterotaxia0.88993349
111MP0010030_abnormal_orbit_morphology0.88149856
112MP0002653_abnormal_ependyma_morphology0.84150834
113MP0000516_abnormal_urinary_system0.83714001
114MP0005367_renal/urinary_system_phenotyp0.83714001
115MP0003937_abnormal_limbs/digits/tail_de0.83222853
116MP0003137_abnormal_impulse_conducting0.82807583
117MP0003861_abnormal_nervous_system0.82734970
118MP0000631_abnormal_neuroendocrine_gland0.82663661
119MP0000026_abnormal_inner_ear0.82067576
120MP0003938_abnormal_ear_development0.81172033
121MP0006276_abnormal_autonomic_nervous0.80956315
122MP0010386_abnormal_urinary_bladder0.80606023
123MP0002095_abnormal_skin_pigmentation0.80513522
124MP0002229_neurodegeneration0.80290984
125MP0003656_abnormal_erythrocyte_physiolo0.79975478
126MP0002114_abnormal_axial_skeleton0.79800624
127MP0003942_abnormal_urinary_system0.79280241
128MP0008789_abnormal_olfactory_epithelium0.78131324
129MP0000534_abnormal_ureter_morphology0.77644164
130MP0004085_abnormal_heartbeat0.77247611
131MP0001963_abnormal_hearing_physiology0.76738508
132MP0001502_abnormal_circadian_rhythm0.76527199
133MP0005410_abnormal_fertilization0.75513390
134MP0000432_abnormal_head_morphology0.75478117
135MP0005248_abnormal_Harderian_gland0.73181638
136MP0001943_abnormal_respiration0.72027180
137MP0003091_abnormal_cell_migration0.71335069
138MP0002108_abnormal_muscle_morphology0.71048868
139MP0002069_abnormal_eating/drinking_beha0.70159918
140MP0005623_abnormal_meninges_morphology0.69974323
141MP0002837_dystrophic_cardiac_calcinosis0.67905915
142MP0003075_altered_response_to0.67622220
143MP0001905_abnormal_dopamine_level0.66853816
144MP0002081_perinatal_lethality0.66589137
145MP0003122_maternal_imprinting0.63510619

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)6.52846371
2Irregular epiphyses (HP:0010582)6.34533778
3Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.26811925
4Vitreoretinal degeneration (HP:0000655)5.14448300
5Hypoplastic ischia (HP:0003175)4.83597286
6Hyperventilation (HP:0002883)4.70848281
7Cupped ribs (HP:0000887)4.52850013
8Flat capital femoral epiphysis (HP:0003370)4.48097201
9Small epiphyses (HP:0010585)4.32637758
10Abnormality of the ischium (HP:0003174)4.19248987
11Abnormal tarsal ossification (HP:0008369)4.00182243
12Mild short stature (HP:0003502)3.94853470
13Flat acetabular roof (HP:0003180)3.88461817
14Genu varum (HP:0002970)3.75922119
15Focal motor seizures (HP:0011153)3.62466398
16Febrile seizures (HP:0002373)3.61048137
17Neonatal short-limb short stature (HP:0008921)3.55222526
18Pancreatic cysts (HP:0001737)3.52199054
19Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.49462762
20Abnormality of femoral epiphyses (HP:0006499)3.49462762
21Pancreatic fibrosis (HP:0100732)3.35056106
22Molar tooth sign on MRI (HP:0002419)3.32037691
23Abnormality of midbrain morphology (HP:0002418)3.32037691
24True hermaphroditism (HP:0010459)3.23142265
25Abnormality of the epiphysis of the femoral head (HP:0010574)3.20893360
26Delayed epiphyseal ossification (HP:0002663)3.14081377
27Metaphyseal dysplasia (HP:0100255)3.14049550
28Abnormality of the pubic bones (HP:0003172)3.13727447
29Nephronophthisis (HP:0000090)3.10750257
30Myokymia (HP:0002411)3.09281866
31Metaphyseal cupping (HP:0003021)3.07730650
32Atonic seizures (HP:0010819)3.05298519
33Inability to walk (HP:0002540)3.04496081
34Chronic hepatic failure (HP:0100626)3.04157527
35Osteoarthritis (HP:0002758)2.98024861
36Gaze-evoked nystagmus (HP:0000640)2.95485045
37Abnormality of the femoral head (HP:0003368)2.90093161
38Drooling (HP:0002307)2.82673763
39Coxa vara (HP:0002812)2.80439533
40Abnormal foot bone ossification (HP:0010675)2.77957325
41Type II lissencephaly (HP:0007260)2.77729130
42Abnormality of the vertebral endplates (HP:0005106)2.74464259
43Short femoral neck (HP:0100864)2.73877452
44Arthropathy (HP:0003040)2.69507057
45Congenital stationary night blindness (HP:0007642)2.69124912
46Progressive inability to walk (HP:0002505)2.68551792
47Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.68342161
48Absent epiphyses (HP:0010577)2.68342161
49Abnormality of the renal medulla (HP:0100957)2.66971760
50Flattened epiphyses (HP:0003071)2.66252396
51Medial flaring of the eyebrow (HP:0010747)2.57099523
52Absent frontal sinuses (HP:0002688)2.57035380
53Hip contracture (HP:0003273)2.56617248
54Excessive salivation (HP:0003781)2.55884692
55Absent speech (HP:0001344)2.55731042
56Abnormality of the proximal phalanges of the hand (HP:0009834)2.55593981
57Dialeptic seizures (HP:0011146)2.54073382
58Focal seizures (HP:0007359)2.51270224
59Spinal cord compression (HP:0002176)2.50963348
60Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.49706064
61Limited hip movement (HP:0008800)2.49593853
62Intestinal atresia (HP:0011100)2.48903291
63Colon cancer (HP:0003003)2.45285764
64Irregular vertebral endplates (HP:0003301)2.44602407
65Abnormality of the renal cortex (HP:0011035)2.43468257
66Abnormality of the labia minora (HP:0012880)2.40671088
67Protruding tongue (HP:0010808)2.40004751
68Attenuation of retinal blood vessels (HP:0007843)2.37165164
69Lissencephaly (HP:0001339)2.36189080
70Hemiparesis (HP:0001269)2.35076076
71Epileptic encephalopathy (HP:0200134)2.32508672
72Relative macrocephaly (HP:0004482)2.29675175
73Waddling gait (HP:0002515)2.29177273
74Abnormality of carpal bone ossification (HP:0006257)2.28605614
75Optic nerve hypoplasia (HP:0000609)2.28576171
76Hypoplasia of the odontoid process (HP:0003311)2.26047039
77Gait imbalance (HP:0002141)2.25432681
78Enlarged epiphyses (HP:0010580)2.24239845
79Abnormality of the phalanges of the 2nd finger (HP:0009541)2.23442189
80Aplasia/hypoplasia of the femur (HP:0005613)2.22787295
81Abnormality of incisor morphology (HP:0011063)2.21960796
82Abolished electroretinogram (ERG) (HP:0000550)2.20527736
83Conical tooth (HP:0000698)2.20522653
84Fetal akinesia sequence (HP:0001989)2.20329149
85Cervical subluxation (HP:0003308)2.20003318
86Broad-based gait (HP:0002136)2.19421771
87Absence seizures (HP:0002121)2.14445164
88Torticollis (HP:0000473)2.13794742
89Limb dystonia (HP:0002451)2.11915989
90Obstructive sleep apnea (HP:0002870)2.11677244
91Exostoses (HP:0100777)2.11156223
92Genital tract atresia (HP:0001827)2.11153084
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.08898307
94Pendular nystagmus (HP:0012043)2.08013163
95Thoracolumbar scoliosis (HP:0002944)2.07927691
96Cystic liver disease (HP:0006706)2.07774727
97Aplasia/Hypoplasia of the tibia (HP:0005772)2.07718414
98Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.06398776
99Thin ribs (HP:0000883)2.06264716
100Aplasia/Hypoplasia of the tongue (HP:0010295)2.05054507
101Pachygyria (HP:0001302)2.03842533
102Metaphyseal irregularity (HP:0003025)2.02337225
103Hepatoblastoma (HP:0002884)2.01408181
104Anencephaly (HP:0002323)2.00476651
105Vaginal atresia (HP:0000148)1.99244335
106Congenital primary aphakia (HP:0007707)1.98756641
107Fair hair (HP:0002286)1.97463252
108Sclerocornea (HP:0000647)1.96807282
109Protuberant abdomen (HP:0001538)1.96792767
110Barrel-shaped chest (HP:0001552)1.96401228
111Cerebellar dysplasia (HP:0007033)1.96345287
112Stomach cancer (HP:0012126)1.95228704
113Long clavicles (HP:0000890)1.94381395
114Platyspondyly (HP:0000926)1.94320702
115Focal dystonia (HP:0004373)1.94025017
116Small hand (HP:0200055)1.93916720
117Ovoid vertebral bodies (HP:0003300)1.93069046
118Genetic anticipation (HP:0003743)1.93002764
119Oligodactyly (hands) (HP:0001180)1.92851130
120Increased corneal curvature (HP:0100692)1.92709441
121Keratoconus (HP:0000563)1.92709441
122Widely spaced teeth (HP:0000687)1.92165040
123Limited elbow extension (HP:0001377)1.91920083
124Volvulus (HP:0002580)1.91636210
125Broad phalanx (HP:0006009)1.89972244
126Progressive cerebellar ataxia (HP:0002073)1.89896871
127Chorioretinal atrophy (HP:0000533)1.89779339
128Broad long bones (HP:0005622)1.89243031
129Overgrowth (HP:0001548)1.88965834
130Abnormality of the odontoid process (HP:0003310)1.88540789
131Abnormality of the 2nd finger (HP:0004100)1.87814194
132Abnormality of the middle phalanges of the hand (HP:0009833)1.87303040
133Postaxial hand polydactyly (HP:0001162)1.87060563
134Abnormal ossification of hand bones (HP:0005921)1.86808245
135Neoplasm of the adrenal cortex (HP:0100641)1.86367688
136Generalized tonic-clonic seizures (HP:0002069)1.84668997
137Retinal dysplasia (HP:0007973)1.83372081
138Bilateral microphthalmos (HP:0007633)1.83307275
139Cupped ear (HP:0000378)1.83247618
140Megalencephaly (HP:0001355)1.83010511
141Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.82582384
142Lower limb asymmetry (HP:0100559)1.82529488
143Abnormal hand bone ossification (HP:0010660)1.82184173
144Shallow orbits (HP:0000586)1.82143828
145Poor eye contact (HP:0000817)1.82057926
146Abnormal vertebral ossification (HP:0100569)1.81402436
147Abnormal drinking behavior (HP:0030082)1.80194808
148Polydipsia (HP:0001959)1.80194808
149Genu recurvatum (HP:0002816)1.80156997
150Mesomelia (HP:0003027)1.79237993
151Broad ribs (HP:0000885)1.79228530
152Nephrogenic diabetes insipidus (HP:0009806)1.79033088
153Anophthalmia (HP:0000528)1.78762566
154Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.78240790
155Radial bowing (HP:0002986)1.77802432
156Renal cortical cysts (HP:0000803)1.77796643
157Decreased central vision (HP:0007663)1.77268074
158Aplasia/Hypoplasia of the uvula (HP:0010293)1.76535837
159Action tremor (HP:0002345)1.76418422
160Protrusio acetabuli (HP:0003179)1.75967814
161Abnormality of alanine metabolism (HP:0010916)1.75710486
162Hyperalaninemia (HP:0003348)1.75710486
163Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75710486
164Short middle phalanx of finger (HP:0005819)1.75403003
165Hypoplastic iliac wings (HP:0002866)1.73860075
166Hypoplastic pelvis (HP:0008839)1.73644647
167Postaxial foot polydactyly (HP:0001830)1.73399940
168Stillbirth (HP:0003826)1.73283368
169Hypoplastic ilia (HP:0000946)1.73263432
170Bulbous nose (HP:0000414)1.73086459
171Abnormal rod and cone electroretinograms (HP:0008323)1.72861061
172Congenital hepatic fibrosis (HP:0002612)1.72689944
173Abnormality of the intervertebral disk (HP:0005108)1.72611664
174Abnormality of the middle phalanges of the toes (HP:0010183)1.70949398
175Tracheomalacia (HP:0002779)1.70749461
176Gastrointestinal atresia (HP:0002589)1.70129383
177Dyskinesia (HP:0100660)1.69654308
178Lumbar hyperlordosis (HP:0002938)1.69123336
179Micromelia (HP:0002983)1.68839920
180Fibular hypoplasia (HP:0003038)1.68175386
181Broad thumb (HP:0011304)1.67617688
182Glioma (HP:0009733)1.67283454
183Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.67130879
184Genu valgum (HP:0002857)1.66985001
185Long nose (HP:0003189)1.66302302
186Bony spicule pigmentary retinopathy (HP:0007737)1.65897540
187Astigmatism (HP:0000483)1.65696204
188Narrow forehead (HP:0000341)1.64455225
189Tubular atrophy (HP:0000092)1.63987413
190Dandy-Walker malformation (HP:0001305)1.63846699
191Preaxial hand polydactyly (HP:0001177)1.61756571
192Disproportionate short-trunk short stature (HP:0003521)1.60206955
193Patellar aplasia (HP:0006443)1.59848480

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.46811905
2FRK4.75347447
3MARK13.51128031
4NTRK33.24855810
5DDR23.21994834
6MAP3K42.86913542
7PRPF4B2.85850569
8ACVR1B2.49685074
9WNK32.40561018
10DAPK22.33215920
11CASK2.23467833
12LATS22.21535951
13NUAK12.19249973
14MAP2K72.15575961
15PAK62.10729223
16PLK22.07964871
17MAP3K92.03215289
18MAP4K21.87229578
19KSR11.85770922
20ZAK1.85575306
21LATS11.83937294
22CAMKK11.78252307
23TAOK11.75302571
24STK38L1.74273839
25OXSR11.71883688
26MINK11.71282358
27NTRK21.70695118
28TAOK21.67600992
29ADRBK21.64318345
30PRKD31.63026315
31MAPK131.53075581
32TLK11.52294584
33ERBB31.45148332
34WNK41.44143668
35KSR21.43359028
36GRK11.41440039
37SGK21.39951069
38STK391.39215117
39INSRR1.36423370
40CAMKK21.35240511
41MAP2K41.33960278
42DAPK11.29235880
43CDK191.23753556
44SGK2231.23747032
45SGK4941.23747032
46PNCK1.19879548
47CDK51.19386896
48SGK31.12813992
49TAOK31.10790759
50MAP3K121.09185395
51FGFR21.05951538
52TNIK1.04590457
53SIK21.04425689
54STK241.02609675
55MOS0.99529448
56NME10.99032153
57SIK30.95162581
58CSNK1G10.93297057
59MAP3K60.92340053
60PHKG20.92275468
61PHKG10.92275468
62TYRO30.91843495
63PKN10.91687037
64NTRK10.91629995
65TRIB30.90962629
66CAMK10.85416326
67PTK2B0.85013803
68DYRK1A0.83221155
69EIF2AK30.82361909
70PLK40.80549705
71STK380.80542280
72OBSCN0.79435260
73DYRK20.79237880
74CDK180.79234775
75PRKCG0.79041921
76SGK10.78445751
77ADRBK10.75558512
78FES0.74266164
79CSNK1G30.74218290
80CSNK1A1L0.73647669
81CAMK2A0.73622207
82CDK150.71354404
83RET0.70677989
84STK110.69457860
85BMPR20.69352518
86DMPK0.68631441
87CAMK1G0.68362507
88CDK140.64862376
89WNK10.63618102
90PRKCH0.62944831
91MAP3K130.59610726
92MAP2K10.59000784
93CDK11A0.58195538
94MUSK0.56919279
95MARK20.56850788
96VRK10.56525072
97MKNK10.56052987
98EPHB20.54359028
99CCNB10.53634541
100RAF10.53261450
101MAP3K20.52629399
102TGFBR10.51559274
103TXK0.50596156
104STK30.47926980
105CSNK1G20.47692606
106PAK30.46896379
107MAP3K30.46812493
108PRKCE0.45475189
109CAMK1D0.44916202
110CAMK2B0.44642862
111PLK30.44476474
112BMX0.42643095
113TRIM280.42379242
114PIK3CA0.42132400
115PDPK10.41833144
116PRKG10.41719800
117AKT30.41617080
118CSNK1D0.41501983
119ERBB40.40935352
120PRKCQ0.39576538
121BMPR1B0.39519173
122MAPK100.38589033
123CSNK1A10.38475074
124MAPK80.38317990
125MKNK20.38080353
126CAMK40.37657457
127BCR0.37607572
128* ROCK10.37171118
129PRKACA0.37018653
130PRKCZ0.36677362
131CAMK2D0.34392678
132DYRK30.34276590
133MAPK120.33987777
134CDK30.33819293
135RPS6KA30.33763606
136PDK10.32824995
137TAF10.32691091
138MST40.32688883
139PRKG20.31795694
140PINK10.31721663
141RIPK10.31379435
142NEK60.31229752
143MAPK70.31160932
144PLK10.30481259
145NEK20.30424471
146ATM0.30198361
147UHMK10.30112442
148BRSK20.29788014
149TIE10.29662984
150GRK50.29501753
151RIPK40.29461378

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.13290169
2Nicotine addiction_Homo sapiens_hsa050332.87706095
3Phototransduction_Homo sapiens_hsa047442.68133427
4Circadian entrainment_Homo sapiens_hsa047132.48024026
5Amphetamine addiction_Homo sapiens_hsa050312.39679946
6Synaptic vesicle cycle_Homo sapiens_hsa047212.29927804
7Morphine addiction_Homo sapiens_hsa050322.20635861
8Long-term potentiation_Homo sapiens_hsa047202.14895856
9GABAergic synapse_Homo sapiens_hsa047272.13956668
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.12146674
11Glutamatergic synapse_Homo sapiens_hsa047242.11778110
12Dopaminergic synapse_Homo sapiens_hsa047282.05622700
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.04349088
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.01604203
15Cocaine addiction_Homo sapiens_hsa050302.01533922
16Cholinergic synapse_Homo sapiens_hsa047251.80658476
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75778914
18Salivary secretion_Homo sapiens_hsa049701.74069429
19Oxytocin signaling pathway_Homo sapiens_hsa049211.72558956
20Butanoate metabolism_Homo sapiens_hsa006501.71436461
21Long-term depression_Homo sapiens_hsa047301.68270001
22Linoleic acid metabolism_Homo sapiens_hsa005911.63621672
23Basal transcription factors_Homo sapiens_hsa030221.62608376
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60748115
25Propanoate metabolism_Homo sapiens_hsa006401.60437678
26Regulation of autophagy_Homo sapiens_hsa041401.58600509
27GnRH signaling pathway_Homo sapiens_hsa049121.56296102
28Fanconi anemia pathway_Homo sapiens_hsa034601.54571977
29Gap junction_Homo sapiens_hsa045401.54175684
30Insulin secretion_Homo sapiens_hsa049111.53789311
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50693986
32Serotonergic synapse_Homo sapiens_hsa047261.50067290
33Renin secretion_Homo sapiens_hsa049241.47390086
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46069392
35ECM-receptor interaction_Homo sapiens_hsa045121.44631915
36Axon guidance_Homo sapiens_hsa043601.44423498
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.42307477
38Glioma_Homo sapiens_hsa052141.40982645
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36091209
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35643991
41Ether lipid metabolism_Homo sapiens_hsa005651.34967429
42Selenocompound metabolism_Homo sapiens_hsa004501.34814477
43Caffeine metabolism_Homo sapiens_hsa002321.33216358
44Taste transduction_Homo sapiens_hsa047421.32586009
45Homologous recombination_Homo sapiens_hsa034401.32428062
46ErbB signaling pathway_Homo sapiens_hsa040121.31569450
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30046072
48Gastric acid secretion_Homo sapiens_hsa049711.28481811
49RNA degradation_Homo sapiens_hsa030181.27628226
50Calcium signaling pathway_Homo sapiens_hsa040201.24353638
51cAMP signaling pathway_Homo sapiens_hsa040241.22475133
52Tryptophan metabolism_Homo sapiens_hsa003801.21679803
53Protein digestion and absorption_Homo sapiens_hsa049741.20522926
54RNA polymerase_Homo sapiens_hsa030201.17548382
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.15934560
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13832290
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12546070
58Estrogen signaling pathway_Homo sapiens_hsa049151.09852795
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09191707
60Endometrial cancer_Homo sapiens_hsa052131.08703749
61Melanogenesis_Homo sapiens_hsa049161.06363484
62cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04359896
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04232798
64Circadian rhythm_Homo sapiens_hsa047101.00283216
65Dilated cardiomyopathy_Homo sapiens_hsa054140.99198514
66Ovarian steroidogenesis_Homo sapiens_hsa049130.98886392
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98579109
68Focal adhesion_Homo sapiens_hsa045100.97431108
69Cardiac muscle contraction_Homo sapiens_hsa042600.96286337
70MAPK signaling pathway_Homo sapiens_hsa040100.94479049
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92341920
72Steroid biosynthesis_Homo sapiens_hsa001000.91601530
73Oxidative phosphorylation_Homo sapiens_hsa001900.88625396
74Type II diabetes mellitus_Homo sapiens_hsa049300.88310787
75Oocyte meiosis_Homo sapiens_hsa041140.86680874
76Wnt signaling pathway_Homo sapiens_hsa043100.86667061
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84305358
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84166933
79Protein export_Homo sapiens_hsa030600.82920155
80Rap1 signaling pathway_Homo sapiens_hsa040150.82176614
81Hippo signaling pathway_Homo sapiens_hsa043900.81913812
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.81749602
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.80774057
84Colorectal cancer_Homo sapiens_hsa052100.79468315
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78867516
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78521304
87Nitrogen metabolism_Homo sapiens_hsa009100.77956922
88Non-homologous end-joining_Homo sapiens_hsa034500.77060457
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77026681
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75879556
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75237827
92Hedgehog signaling pathway_Homo sapiens_hsa043400.75177066
93mTOR signaling pathway_Homo sapiens_hsa041500.73356717
94Choline metabolism in cancer_Homo sapiens_hsa052310.73351953
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72565937
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.72488193
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71807691
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71741263
99Parkinsons disease_Homo sapiens_hsa050120.70408789
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.70336014
101Ras signaling pathway_Homo sapiens_hsa040140.70296560
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67106681
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.66255872
104Melanoma_Homo sapiens_hsa052180.65989846
105Non-small cell lung cancer_Homo sapiens_hsa052230.65609056
106Dorso-ventral axis formation_Homo sapiens_hsa043200.64367902
107Proteoglycans in cancer_Homo sapiens_hsa052050.62516737
108ABC transporters_Homo sapiens_hsa020100.62273322
109VEGF signaling pathway_Homo sapiens_hsa043700.61456153
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.60248087
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58667160
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58434072
113Vibrio cholerae infection_Homo sapiens_hsa051100.57266580
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56686518
115TGF-beta signaling pathway_Homo sapiens_hsa043500.56183926
116Thyroid hormone synthesis_Homo sapiens_hsa049180.56102813
117Glucagon signaling pathway_Homo sapiens_hsa049220.55799709
118Basal cell carcinoma_Homo sapiens_hsa052170.55456695
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54916722
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54611302
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52954408
122Purine metabolism_Homo sapiens_hsa002300.50968010
123Fat digestion and absorption_Homo sapiens_hsa049750.50911275
124Alzheimers disease_Homo sapiens_hsa050100.50857171
125FoxO signaling pathway_Homo sapiens_hsa040680.50836069
126Insulin signaling pathway_Homo sapiens_hsa049100.50738973
127Renal cell carcinoma_Homo sapiens_hsa052110.50379732
128Glycerolipid metabolism_Homo sapiens_hsa005610.49781958
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49746932
130Bladder cancer_Homo sapiens_hsa052190.49543982
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47904365
132Retinol metabolism_Homo sapiens_hsa008300.47838771
133Mineral absorption_Homo sapiens_hsa049780.47436894
134Huntingtons disease_Homo sapiens_hsa050160.46738074
135Collecting duct acid secretion_Homo sapiens_hsa049660.46018911
136Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45753316
137Chemical carcinogenesis_Homo sapiens_hsa052040.45512936
138beta-Alanine metabolism_Homo sapiens_hsa004100.43378136
139Adherens junction_Homo sapiens_hsa045200.41725506
140Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41465257
141Pancreatic cancer_Homo sapiens_hsa052120.41278680
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41260947
143Intestinal immune network for IgA production_Homo sapiens_hsa046720.40953516
144Alcoholism_Homo sapiens_hsa050340.40073241
145Prolactin signaling pathway_Homo sapiens_hsa049170.40052081
146Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39668659
147Pancreatic secretion_Homo sapiens_hsa049720.38239431
148Vitamin B6 metabolism_Homo sapiens_hsa007500.35718859
149Peroxisome_Homo sapiens_hsa041460.35323017
150Cysteine and methionine metabolism_Homo sapiens_hsa002700.35254011
151Lysine degradation_Homo sapiens_hsa003100.32548850

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