TICAM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)4.66637585
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.35689498
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.35689498
4antigen processing and presentation of endogenous antigen (GO:0019883)4.14861203
5regulation of vitamin metabolic process (GO:0030656)3.85166239
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.62720093
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.62720093
8positive regulation by organism of defense response of other organism involved in symbiotic interact3.62720093
9modulation by symbiont of host immune response (GO:0052553)3.62720093
10positive regulation by symbiont of host defense response (GO:0052509)3.62720093
11modulation by symbiont of host defense response (GO:0052031)3.62720093
12regulation of T-helper 1 cell differentiation (GO:0045625)3.58063573
13germinal center formation (GO:0002467)3.54304561
14regulation of podosome assembly (GO:0071801)3.53969477
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.49730088
16T-helper 1 type immune response (GO:0042088)3.49509895
17negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.48068241
18* regulation of interferon-beta biosynthetic process (GO:0045357)3.41057209
19myeloid dendritic cell differentiation (GO:0043011)3.39109613
20negative regulation of erythrocyte differentiation (GO:0045647)3.30086180
21regulation of cytokine secretion involved in immune response (GO:0002739)3.27501436
22interferon-gamma-mediated signaling pathway (GO:0060333)3.23401491
23negative regulation of cytokine production involved in immune response (GO:0002719)3.22798064
24response to protozoan (GO:0001562)3.17390956
25positive regulation of gamma-delta T cell activation (GO:0046645)3.16240403
26triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.16190598
27positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.14002855
28regulation of dendritic cell antigen processing and presentation (GO:0002604)3.10186263
29positive regulation of interferon-alpha production (GO:0032727)3.08779428
30detection of other organism (GO:0098543)3.08638473
31regulation of T-helper 2 cell differentiation (GO:0045628)3.06561819
32positive regulation of type 2 immune response (GO:0002830)3.04314722
33activation of MAPKKK activity (GO:0000185)3.03979433
34regulation of type I interferon-mediated signaling pathway (GO:0060338)3.03957588
35regulation of chronic inflammatory response (GO:0002676)3.02805467
36regulation of membrane protein ectodomain proteolysis (GO:0051043)3.01868743
37positive regulation of NF-kappaB import into nucleus (GO:0042346)3.01627511
38negative regulation of cell killing (GO:0031342)3.00827755
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.00827755
40detection of bacterium (GO:0016045)3.00667792
41regulation of interferon-alpha production (GO:0032647)2.92721126
42regulation of cholesterol storage (GO:0010885)2.92478495
43low-density lipoprotein particle clearance (GO:0034383)2.90560707
44regulation of cholesterol homeostasis (GO:2000188)2.90544132
45positive regulation of heat generation (GO:0031652)2.90333244
46myeloid dendritic cell activation (GO:0001773)2.89963661
47regulation of type 2 immune response (GO:0002828)2.88732945
48regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.88079322
49fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.87441865
50regulation of interleukin-12 biosynthetic process (GO:0045075)2.83886028
51intestinal cholesterol absorption (GO:0030299)2.83139742
52cellular response to zinc ion (GO:0071294)2.80822037
53negative regulation of myeloid cell apoptotic process (GO:0033033)2.75525545
54* regulation of chemokine biosynthetic process (GO:0045073)2.74978800
55positive regulation of B cell differentiation (GO:0045579)2.74853261
56protein localization to endosome (GO:0036010)2.74293422
57kynurenine metabolic process (GO:0070189)2.73971483
58phospholipid efflux (GO:0033700)2.73714534
59* positive regulation of chemokine biosynthetic process (GO:0045080)2.73360248
60regulation of fever generation (GO:0031620)2.72380188
61plasma lipoprotein particle clearance (GO:0034381)2.72360404
62granulocyte activation (GO:0036230)2.71856175
63regulation of interleukin-8 biosynthetic process (GO:0045414)2.71181312
64glycosphingolipid catabolic process (GO:0046479)2.71000268
65alpha-linolenic acid metabolic process (GO:0036109)2.69596336
66positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.69218678
67detection of external biotic stimulus (GO:0098581)2.69075239
68peptidyl-glutamic acid carboxylation (GO:0017187)2.68704297
69protein carboxylation (GO:0018214)2.68704297
70positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.65863368
71neutrophil activation involved in immune response (GO:0002283)2.64721285
72* macrophage activation involved in immune response (GO:0002281)2.64493055
73dendritic cell differentiation (GO:0097028)2.64260960
74tryptophan catabolic process (GO:0006569)2.64010849
75indole-containing compound catabolic process (GO:0042436)2.64010849
76indolalkylamine catabolic process (GO:0046218)2.64010849
77regulation of antigen processing and presentation (GO:0002577)2.63995352
78regulation of triglyceride catabolic process (GO:0010896)2.63705288
79positive regulation of transcription factor import into nucleus (GO:0042993)2.63618901
80regulation of gamma-delta T cell differentiation (GO:0045586)2.62962403
81response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.62860938
82response to host (GO:0075136)2.62860938
83response to host defenses (GO:0052200)2.62860938
84negative regulation of nitric oxide biosynthetic process (GO:0045019)2.62695583
85B cell mediated immunity (GO:0019724)2.61638371
86* cellular response to lipopolysaccharide (GO:0071222)2.61350541
87immunoglobulin mediated immune response (GO:0016064)2.59900901
88response to peptidoglycan (GO:0032494)2.58150073
89protein-lipid complex assembly (GO:0065005)2.58043216
90urea cycle (GO:0000050)2.57666026
91urea metabolic process (GO:0019627)2.57666026
92cellular response to interferon-gamma (GO:0071346)2.57570373
93regulation of gamma-delta T cell activation (GO:0046643)2.57345186
94regulation of mononuclear cell migration (GO:0071675)2.57187655
95valine metabolic process (GO:0006573)2.56779190
96negative regulation of cholesterol transport (GO:0032375)2.56385176
97negative regulation of sterol transport (GO:0032372)2.56385176
98phospholipid homeostasis (GO:0055091)2.56277702
99plasma lipoprotein particle assembly (GO:0034377)2.55775463
100positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.55737133
101JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.55439789
102tryptophan metabolic process (GO:0006568)2.55185410
103* cellular response to molecule of bacterial origin (GO:0071219)2.54016954
104regulation of interleukin-12 production (GO:0032655)2.53822486
105modulation by symbiont of host cellular process (GO:0044068)2.53760568
106virion attachment to host cell (GO:0019062)2.53352666
107adhesion of symbiont to host cell (GO:0044650)2.53352666
108cellular response to thyroid hormone stimulus (GO:0097067)2.51643407
109positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.51307533
110CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.49440659
111positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.49222417
112Arp2/3 complex-mediated actin nucleation (GO:0034314)2.48695192
113high-density lipoprotein particle remodeling (GO:0034375)2.47884776
114regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.47736930
115positive regulation of Cdc42 GTPase activity (GO:0043089)2.47260338
116mannose metabolic process (GO:0006013)2.46761318
117detection of biotic stimulus (GO:0009595)2.46645967
118apoptotic cell clearance (GO:0043277)2.45804854
119negative regulation of production of molecular mediator of immune response (GO:0002701)2.45580993
120positive regulation of antigen processing and presentation (GO:0002579)2.45135993
121positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.45022846
122respiratory burst (GO:0045730)2.44853871
123positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.44789507
124reverse cholesterol transport (GO:0043691)2.44116832
125glycolipid catabolic process (GO:0019377)2.43871122
126aromatic amino acid family catabolic process (GO:0009074)2.42908295
127positive regulation of triglyceride metabolic process (GO:0090208)2.41705578
128sulfur amino acid catabolic process (GO:0000098)2.39645607
129lipoprotein metabolic process (GO:0042157)2.38085210
130pinocytosis (GO:0006907)2.37041687
131regulation of cholesterol esterification (GO:0010872)2.36336968
132intestinal absorption (GO:0050892)2.35692028
133response to type I interferon (GO:0034340)2.35131604
134positive regulation of lipoprotein lipase activity (GO:0051006)2.34366269
135positive regulation of triglyceride lipase activity (GO:0061365)2.34366269
136lysine metabolic process (GO:0006553)2.32694231
137lysine catabolic process (GO:0006554)2.32694231
138antigen processing and presentation via MHC class Ib (GO:0002475)2.32379625
139defense response to protozoan (GO:0042832)2.32375875
140* lipopolysaccharide-mediated signaling pathway (GO:0031663)2.31843793
141hydrogen peroxide biosynthetic process (GO:0050665)2.30215662
142negative regulation of fibrinolysis (GO:0051918)2.30215423
143type I interferon signaling pathway (GO:0060337)2.29772804
144cellular response to type I interferon (GO:0071357)2.29772804
145protein-lipid complex remodeling (GO:0034368)2.29539824
146macromolecular complex remodeling (GO:0034367)2.29539824
147plasma lipoprotein particle remodeling (GO:0034369)2.29539824
148positive regulation of natural killer cell differentiation (GO:0032825)2.28914891
149negative regulation of interleukin-12 production (GO:0032695)2.28052091
150response to muramyl dipeptide (GO:0032495)2.27625890
151positive regulation of lipid storage (GO:0010884)2.27467652
152COPI coating of Golgi vesicle (GO:0048205)2.27056703
153Golgi transport vesicle coating (GO:0048200)2.27056703
154nitrogen cycle metabolic process (GO:0071941)2.27036740
155NIK/NF-kappaB signaling (GO:0038061)2.26963146
156homocysteine metabolic process (GO:0050667)2.26269300
157detection of molecule of bacterial origin (GO:0032490)2.26215928
158mature B cell differentiation involved in immune response (GO:0002313)2.25203704
159mature B cell differentiation (GO:0002335)2.25122650
160I-kappaB phosphorylation (GO:0007252)2.24364345
161positive regulation of lipid catabolic process (GO:0050996)2.23970326
162response to host immune response (GO:0052572)2.23930002
163response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.23930002
164reactive oxygen species biosynthetic process (GO:1903409)2.23920372
165tricarboxylic acid metabolic process (GO:0072350)2.23227695
166regulation of B cell differentiation (GO:0045577)2.22739345
167positive regulation of triglyceride biosynthetic process (GO:0010867)2.22255028
1682-oxoglutarate metabolic process (GO:0006103)2.21002655

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.41514893
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.27715639
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.40877016
4* RXR_22158963_ChIP-Seq_LIVER_Mouse3.14735472
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.07138224
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.02038576
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.85041285
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.57047991
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53341455
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.49355755
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42209536
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.42136351
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39697904
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.39392159
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.37528370
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.36404709
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.35043678
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.34438280
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.28578893
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26678508
21MYC_22102868_ChIP-Seq_BL_Human2.12932916
22VDR_21846776_ChIP-Seq_THP-1_Human2.08899615
23* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.08624289
24TP63_17297297_ChIP-ChIP_HaCaT_Human2.07818338
25BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96404389
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.90206497
27GATA1_22025678_ChIP-Seq_K562_Human1.80603931
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.79682023
29FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.78745445
30VDR_24763502_ChIP-Seq_THP-1_Human1.77481873
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76618823
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74967908
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.74642999
34SCL_19346495_ChIP-Seq_HPC-7_Human1.72986444
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.70767479
36MAF_26560356_Chip-Seq_TH1_Human1.70082442
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.69174200
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66864594
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64315843
40TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64122039
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.62835748
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61003695
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59721083
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.57622988
45TCF7_22412390_ChIP-Seq_EML_Mouse1.56490302
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.55952886
47SPI1_23547873_ChIP-Seq_NB4_Human1.52861480
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51745722
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51286761
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46950116
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.45527199
52* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45327763
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.45088554
54MYB_26560356_Chip-Seq_TH2_Human1.42618477
55UTX_26944678_Chip-Seq_JUKART_Human1.42380687
56* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37891042
57PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36951908
58CLOCK_20551151_ChIP-Seq_293T_Human1.36496808
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36215312
60NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36131576
61MYB_26560356_Chip-Seq_TH1_Human1.34109699
62SPI1_23127762_ChIP-Seq_K562_Human1.30949267
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.29712642
64LXR_22292898_ChIP-Seq_THP-1_Human1.29202110
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28617031
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27872745
67ZNF263_19887448_ChIP-Seq_K562_Human1.27773482
68EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.26757041
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26696111
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24342859
71* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24224723
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20440099
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19900343
74KDM2B_26808549_Chip-Seq_K562_Human1.19598732
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19406264
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17820787
77PU_27001747_Chip-Seq_BMDM_Mouse1.17769894
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16985616
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15408703
80RUNX_20019798_ChIP-Seq_JUKART_Human1.15174214
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14779646
82KDM2B_26808549_Chip-Seq_DND41_Human1.12905346
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12562221
84* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11953846
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11404228
86PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10967615
87VDR_24787735_ChIP-Seq_THP-1_Human1.10563185
88KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10388820
89BCOR_27268052_Chip-Seq_Bcells_Human1.10110908
90PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09402067
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09281398
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09054767
93SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08921444
94CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08900121
95RACK7_27058665_Chip-Seq_MCF-7_Human1.08775298
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08732699
97KDM2B_26808549_Chip-Seq_JURKAT_Human1.08395891
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08243067
99GATA1_19941827_ChIP-Seq_MEL_Mouse1.08144314
100SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07610845
101SMAD_19615063_ChIP-ChIP_OVARY_Human1.07583376
102SA1_27219007_Chip-Seq_ERYTHROID_Human1.05853580
103ELF1_20517297_ChIP-Seq_JURKAT_Human1.05131263
104PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04789044
105BCL6_27268052_Chip-Seq_Bcells_Human1.04629618
106GATA2_21666600_ChIP-Seq_HMVEC_Human1.02406170
107GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02291007
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01886325
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00761425
110SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00667187
111GATA1_19941826_ChIP-Seq_K562_Human1.00136408
112MAF_26560356_Chip-Seq_TH2_Human0.99782310
113NCOR1_26117541_ChIP-Seq_K562_Human0.98819014
114CDX2_20551321_ChIP-Seq_CACO-2_Human0.98534260
115GATA4_25053715_ChIP-Seq_YYC3_Human0.98521183
116GATA6_25053715_ChIP-Seq_YYC3_Human0.98227096
117ATF3_27146783_Chip-Seq_COLON_Human0.97576155
118STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95932199
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95594160
120TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94398261
121TRIM28_21343339_ChIP-Seq_HEK293_Human0.93572122
122HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93231989
123GATA2_19941826_ChIP-Seq_K562_Human0.93122770
124GATA3_27048872_Chip-Seq_THYMUS_Human0.92208919

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.54867023
2MP0009840_abnormal_foam_cell2.86998181
3MP0002139_abnormal_hepatobiliary_system2.84807511
4MP0001835_abnormal_antigen_presentation2.71793039
5MP0003436_decreased_susceptibility_to2.49908628
6MP0003303_peritoneal_inflammation2.48521203
7MP0005365_abnormal_bile_salt2.42293843
8MP0005058_abnormal_lysosome_morphology2.29109838
9MP0003300_gastrointestinal_ulcer2.18037355
10MP0003191_abnormal_cellular_cholesterol2.17454305
11MP0009785_altered_susceptibility_to2.00234810
12MP0005085_abnormal_gallbladder_physiolo1.95226803
13MP0003705_abnormal_hypodermis_morpholog1.93971110
14MP0001666_abnormal_nutrient_absorption1.88874862
15MP0005387_immune_system_phenotype1.87729813
16MP0001790_abnormal_immune_system1.87729813
17* MP0002419_abnormal_innate_immunity1.87047830
18* MP0005025_abnormal_response_to1.80927395
19MP0003252_abnormal_bile_duct1.80303538
20MP0000685_abnormal_immune_system1.80097992
21MP0005000_abnormal_immune_tolerance1.72537440
22* MP0001800_abnormal_humoral_immune1.72019630
23MP0005464_abnormal_platelet_physiology1.71978726
24MP0008004_abnormal_stomach_pH1.67659488
25* MP0002452_abnormal_antigen_presenting1.66962603
26MP0008875_abnormal_xenobiotic_pharmacok1.65137889
27MP0004510_myositis1.60347425
28MP0006082_CNS_inflammation1.59920574
29MP0002148_abnormal_hypersensitivity_rea1.58696137
30MP0003724_increased_susceptibility_to1.55490404
31MP0002166_altered_tumor_susceptibility1.54223747
32MP0010329_abnormal_lipoprotein_level1.53633568
33* MP0002723_abnormal_immune_serum1.52818092
34MP0004947_skin_inflammation1.51698325
35MP0010155_abnormal_intestine_physiology1.49803967
36MP0010352_gastrointestinal_tract_polyps1.49281879
37MP0005671_abnormal_response_to1.45647810
38MP0001853_heart_inflammation1.45341947
39* MP0001845_abnormal_inflammatory_respons1.43982629
40MP0003566_abnormal_cell_adhesion1.43521415
41MP0001533_abnormal_skeleton_physiology1.41498402
42MP0000609_abnormal_liver_physiology1.40276676
43MP0002138_abnormal_hepatobiliary_system1.39439443
44* MP0008469_abnormal_protein_level1.39059118
45* MP0001819_abnormal_immune_cell1.39050721
46* MP0002420_abnormal_adaptive_immunity1.37894224
47MP0005083_abnormal_biliary_tract1.36249042
48MP0003172_abnormal_lysosome_physiology1.35715862
49MP0003763_abnormal_thymus_physiology1.34603708
50MP0003091_abnormal_cell_migration1.34386378
51MP0003828_pulmonary_edema1.29179306
52MP0001873_stomach_inflammation1.26356196
53* MP0005166_decreased_susceptibility_to1.25085067
54MP0002405_respiratory_system_inflammati1.25053223
55MP0008260_abnormal_autophagy1.24461452
56MP0009643_abnormal_urine_homeostasis1.23283612
57MP0002332_abnormal_exercise_endurance1.22334247
58MP0009764_decreased_sensitivity_to1.21940209
59* MP0009333_abnormal_splenocyte_physiolog1.21146967
60MP0005332_abnormal_amino_acid1.19327066
61MP0005319_abnormal_enzyme/_coenzyme1.17850805
62MP0010234_abnormal_vibrissa_follicle1.15397392
63MP0002006_tumorigenesis1.15157277
64MP0005023_abnormal_wound_healing1.14271846
65* MP0000716_abnormal_immune_system1.13018890
66MP0003806_abnormal_nucleotide_metabolis1.12397818
67MP0000343_altered_response_to1.12264488
68MP0002398_abnormal_bone_marrow1.11011053
69MP0003656_abnormal_erythrocyte_physiolo1.09918631
70MP0009278_abnormal_bone_marrow1.07891464
71MP0003866_abnormal_defecation1.07631214
72MP0005076_abnormal_cell_differentiation1.06356748
73MP0000689_abnormal_spleen_morphology1.05684431
74MP0005397_hematopoietic_system_phenotyp1.05650555
75MP0001545_abnormal_hematopoietic_system1.05650555
76MP0000858_altered_metastatic_potential1.02648447
77MP0005164_abnormal_response_to1.02584163
78MP0003186_abnormal_redox_activity1.01494787
79MP0005390_skeleton_phenotype1.00989156
80MP0000598_abnormal_liver_morphology1.00934328
81* MP0002429_abnormal_blood_cell0.99470799
82MP0002722_abnormal_immune_system0.99401552
83MP0008438_abnormal_cutaneous_collagen0.97187439
84MP0003183_abnormal_peptide_metabolism0.96175940
85MP0002118_abnormal_lipid_homeostasis0.96097447
86MP0010307_abnormal_tumor_latency0.94743435
87MP0002796_impaired_skin_barrier0.93697320
88MP0002396_abnormal_hematopoietic_system0.92252529
89MP0002877_abnormal_melanocyte_morpholog0.92190643
90MP0002136_abnormal_kidney_physiology0.91943487
91MP0005310_abnormal_salivary_gland0.91301413
92MP0000604_amyloidosis0.91236009
93MP0002254_reproductive_system_inflammat0.91223736
94MP0003195_calcinosis0.90028020
95MP0009763_increased_sensitivity_to0.89410994
96MP0005451_abnormal_body_composition0.89359660
97MP0002933_joint_inflammation0.89257583
98MP0001851_eye_inflammation0.89178498
99MP0005584_abnormal_enzyme/coenzyme_acti0.88350250
100MP0001216_abnormal_epidermal_layer0.88337130
101MP0000490_abnormal_crypts_of0.88123828
102MP0006054_spinal_hemorrhage0.87811602
103MP0002998_abnormal_bone_remodeling0.85120431
104MP0000249_abnormal_blood_vessel0.84959251
105MP0003075_altered_response_to0.84889224
106MP0005165_increased_susceptibility_to0.84476195
107MP0004808_abnormal_hematopoietic_stem0.84256229
108* MP0003448_altered_tumor_morphology0.83560498
109MP0004264_abnormal_extraembryonic_tissu0.82852079
110MP0001542_abnormal_bone_strength0.82620239
111MP0003279_aneurysm0.81579154
112MP0003690_abnormal_glial_cell0.80960064
113MP0000767_abnormal_smooth_muscle0.80733267
114MP0001849_ear_inflammation0.79950781
115MP0005167_abnormal_blood-brain_barrier0.79915305
116MP0000465_gastrointestinal_hemorrhage0.79758197
117MP0001663_abnormal_digestive_system0.79594960
118MP0003453_abnormal_keratinocyte_physiol0.78645028
119MP0004019_abnormal_vitamin_homeostasis0.77733211
120MP0003045_fibrosis0.73646315
121MP0003795_abnormal_bone_structure0.72535806
122MP0008874_decreased_physiological_sensi0.71584414
123MP0005666_abnormal_adipose_tissue0.71376113
124MP0000678_abnormal_parathyroid_gland0.68990193
125MP0004883_abnormal_blood_vessel0.65871116
126MP0005257_abnormal_intraocular_pressure0.62523763

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)4.97694682
2Abnormality of liposaccharide metabolism (HP:0010968)4.97694682
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.97694682
4Eczematoid dermatitis (HP:0000976)3.87591027
5Recurrent abscess formation (HP:0002722)3.61217933
6Recurrent bacterial skin infections (HP:0005406)3.54899288
7Loss of speech (HP:0002371)3.49829835
8Recurrent gram-negative bacterial infections (HP:0005420)3.45628457
9Optic neuritis (HP:0100653)3.44234221
10Retrobulbar optic neuritis (HP:0100654)3.44234221
11Autoimmune thrombocytopenia (HP:0001973)3.41390181
12Myocardial infarction (HP:0001658)3.22650945
13Stomatitis (HP:0010280)3.10021603
14Vacuolated lymphocytes (HP:0001922)3.04704316
15Abnormality of glutamine family amino acid metabolism (HP:0010902)3.01137688
16Xanthomatosis (HP:0000991)2.97738994
17Abnormality of macrophages (HP:0004311)2.96948178
18Systemic lupus erythematosus (HP:0002725)2.95674070
19Increased IgE level (HP:0003212)2.89923368
20Elevated erythrocyte sedimentation rate (HP:0003565)2.79134905
21Recurrent fungal infections (HP:0002841)2.78992644
22Urinary glycosaminoglycan excretion (HP:0003541)2.76003464
23Mucopolysacchariduria (HP:0008155)2.76003464
24Hypoglycemic coma (HP:0001325)2.75574662
25Nuclear cataract (HP:0100018)2.75481227
26Recurrent skin infections (HP:0001581)2.71339764
27Deep venous thrombosis (HP:0002625)2.71094237
28Myositis (HP:0100614)2.69803350
29Increased cerebral lipofuscin (HP:0011813)2.67778698
30Abnormality of monocarboxylic acid metabolism (HP:0010996)2.65837982
31Pustule (HP:0200039)2.64447821
32* Recurrent viral infections (HP:0004429)2.63698254
33Axonal loss (HP:0003447)2.57949170
34Gastrointestinal stroma tumor (HP:0100723)2.56723604
35Hydroxyprolinuria (HP:0003080)2.56137495
36Abnormality of proline metabolism (HP:0010907)2.56137495
37Colitis (HP:0002583)2.54701133
38Dysostosis multiplex (HP:0000943)2.54135152
39Interstitial pulmonary disease (HP:0006530)2.52082709
40Abnormality of polysaccharide metabolism (HP:0011012)2.51550795
41Abnormality of glycosaminoglycan metabolism (HP:0004371)2.51550795
42Abnormality of mucopolysaccharide metabolism (HP:0011020)2.51550795
43Keratoconjunctivitis sicca (HP:0001097)2.50502366
44Abnormality of the common coagulation pathway (HP:0010990)2.48510885
45Amyloidosis (HP:0011034)2.46651200
46Cellulitis (HP:0100658)2.44795183
47Gingival bleeding (HP:0000225)2.43296960
48Obstructive lung disease (HP:0006536)2.42987358
49Chronic obstructive pulmonary disease (HP:0006510)2.42987358
50Increased neuronal autofluorescent lipopigment (HP:0002074)2.40863700
51Pulmonary infiltrates (HP:0002113)2.40402115
52Nausea (HP:0002018)2.36290460
53Malnutrition (HP:0004395)2.35886856
54Disinhibition (HP:0000734)2.34514124
55Abnormality of aromatic amino acid family metabolism (HP:0004338)2.33295362
56Generalized aminoaciduria (HP:0002909)2.33064431
57Thrombocytosis (HP:0001894)2.29891459
58Purpura (HP:0000979)2.28255013
59Emphysema (HP:0002097)2.27958861
60Thin bony cortex (HP:0002753)2.27898553
61Gingivitis (HP:0000230)2.25513495
62Neurofibrillary tangles (HP:0002185)2.24637451
63Complement deficiency (HP:0004431)2.24565038
64Hypobetalipoproteinemia (HP:0003563)2.24007161
65Abnormality of purine metabolism (HP:0004352)2.23009021
66Arterial thrombosis (HP:0004420)2.21212461
67Orchitis (HP:0100796)2.21079517
68Intrahepatic cholestasis (HP:0001406)2.20524985
69Keratoconjunctivitis (HP:0001096)2.19869568
70Periodontitis (HP:0000704)2.19864019
71Progressive neurologic deterioration (HP:0002344)2.18724569
72Joint hemorrhage (HP:0005261)2.18215017
73Impaired platelet aggregation (HP:0003540)2.17737780
74Abnormal platelet function (HP:0011869)2.17737780
75Increased IgM level (HP:0003496)2.17570185
76Polycythemia (HP:0001901)2.14733873
77Chronic otitis media (HP:0000389)2.14289280
78Gangrene (HP:0100758)2.13024702
79Chronic mucocutaneous candidiasis (HP:0002728)2.10964926
80Recurrent cutaneous fungal infections (HP:0011370)2.10964926
81Cervical subluxation (HP:0003308)2.10801127
82Inflammation of the large intestine (HP:0002037)2.10582683
83Hypergammaglobulinemia (HP:0010702)2.10408703
84Peritonitis (HP:0002586)2.10383401
85Petechiae (HP:0000967)2.09223880
86Hypertensive crisis (HP:0100735)2.08502990
87Abnormality of fatty-acid metabolism (HP:0004359)2.07595134
88Hyperammonemia (HP:0001987)2.06326707
89Abnormality of complement system (HP:0005339)2.06206329
90Glomerulonephritis (HP:0000099)2.06155159
91Esophageal varix (HP:0002040)2.05876853
92Gastrointestinal inflammation (HP:0004386)2.05510475
93Neuronal loss in central nervous system (HP:0002529)2.03150527
94Abnormality of sulfur amino acid metabolism (HP:0004339)2.02836073
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02581444
96Menorrhagia (HP:0000132)2.02118137
97Vasculitis (HP:0002633)2.01003812
98Increased serum ferritin (HP:0003281)2.00912964
99Vertebral compression fractures (HP:0002953)2.00711259
100Abnormal delayed hypersensitivity skin test (HP:0002963)1.99091193
101Urticaria (HP:0001025)1.98857589
102Parakeratosis (HP:0001036)1.98786486
103Abnormality of nucleobase metabolism (HP:0010932)1.98746268
104Spondylolisthesis (HP:0003302)1.98701162
105Asymmetric septal hypertrophy (HP:0001670)1.96391742
106Epistaxis (HP:0000421)1.95584895
107Hemoptysis (HP:0002105)1.95195720
108Nasal polyposis (HP:0100582)1.95119878
109Mediastinal lymphadenopathy (HP:0100721)1.95029708
110Abnormality of iron homeostasis (HP:0011031)1.94834451
111Hepatosplenomegaly (HP:0001433)1.94787903
112Agammaglobulinemia (HP:0004432)1.94124421
113Ketosis (HP:0001946)1.94041066
114Segmental peripheral demyelination/remyelination (HP:0003481)1.93484292
115Abnormality of the nasal mucosa (HP:0000433)1.92715515
116Apathy (HP:0000741)1.92508075
117Hyperglycinuria (HP:0003108)1.92393746
118Mutism (HP:0002300)1.92188233
119Abnormality of transition element cation homeostasis (HP:0011030)1.91385726
120Polygenic inheritance (HP:0010982)1.91309533
121Abnormal platelet volume (HP:0011876)1.90740453
122Hypolipoproteinemia (HP:0010981)1.90387390
123Restrictive lung disease (HP:0002091)1.90203398
124Prolonged neonatal jaundice (HP:0006579)1.90018173
125Prolonged partial thromboplastin time (HP:0003645)1.89046423
126Gastrointestinal infarctions (HP:0005244)1.89045702
127Diminished motivation (HP:0000745)1.88444613
128Abnormality of T cell physiology (HP:0011840)1.87013251
129Increased mean platelet volume (HP:0011877)1.86712833
130Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.85639789
131Bone pain (HP:0002653)1.84982966
132Achilles tendon contracture (HP:0001771)1.83424422
133Osteomyelitis (HP:0002754)1.83348539
134Abnormality of the intrinsic pathway (HP:0010989)1.83193469
135Acne (HP:0001061)1.82928475
136Meningitis (HP:0001287)1.82210231
137Fat malabsorption (HP:0002630)1.81052550
138Osteolytic defects of the hand bones (HP:0009699)1.80180705
139Osteolytic defects of the phalanges of the hand (HP:0009771)1.80180705
140Encephalitis (HP:0002383)1.80123421
141Hyperlipoproteinemia (HP:0010980)1.79942621
142Mitral stenosis (HP:0001718)1.79896358
143Right ventricular cardiomyopathy (HP:0011663)1.79826007
144Hypoalphalipoproteinemia (HP:0003233)1.79443675
145Distal lower limb muscle weakness (HP:0009053)1.79345830
146Nephritis (HP:0000123)1.78703952
147Hyperparathyroidism (HP:0000843)1.78178028
148Cerebral inclusion bodies (HP:0100314)1.78039918
149Hematochezia (HP:0002573)1.76601361
150Upper motor neuron abnormality (HP:0002127)1.74850437
151Arthralgia (HP:0002829)1.74545919
152Thick nail (HP:0001805)1.74070375
153Spontaneous hematomas (HP:0007420)1.73991829
154Hemorrhage of the eye (HP:0011885)1.70336711
155Thoracic kyphosis (HP:0002942)1.69746091

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.72799932
2PRPF4B3.30067833
3TRIB33.15323722
4MAP4K13.15258100
5TAOK32.90997158
6PKN22.54404540
7TYK22.39432371
8TBK12.36775153
9IRAK32.31206453
10MAP3K102.11596286
11BLK1.96617058
12JAK31.85387465
13SIK11.83500970
14MAP3K141.77243166
15SMG11.77009542
16FGFR41.76365632
17DDR21.75046476
18PIM21.71278111
19FLT31.69177244
20KIT1.68536569
21ZAP701.61665031
22JAK11.59995756
23EPHB11.57703172
24GRK71.56720691
25PTK61.54164707
26BCKDK1.47759480
27IKBKE1.45785049
28STK101.45632253
29MST1R1.42121202
30EEF2K1.39972700
31ICK1.39915623
32MAP2K31.38691761
33NEK91.37835435
34MAP3K11.37047606
35RPS6KA41.35264775
36CSF1R1.33772550
37MOS1.33738780
38RIPK11.33219967
39LRRK21.32295805
40IKBKB1.32218353
41EPHA31.23451831
42TTN1.22468488
43IRAK21.21623037
44SIK31.20636864
45BTK1.19380181
46TGFBR21.18893754
47IRAK41.17356361
48FGR1.12815676
49TESK11.11897376
50CAMK1D1.11056552
51NME21.11010419
52CSK1.08229632
53ARAF1.06744316
54MAP3K31.06002534
55BMPR21.05635887
56GRK61.05081112
57CHUK1.03943601
58EPHA21.02833330
59TESK21.00217255
60PIM10.96884425
61MAP3K110.96211181
62IRAK10.95103013
63SYK0.94509312
64RIPK40.93788063
65MAPK110.91703759
66TXK0.90706951
67BMX0.90000305
68JAK20.86869508
69FGFR30.84139215
70TEC0.80067107
71KDR0.79704410
72PRKG20.79324898
73HCK0.79245272
74MYLK0.79071512
75MAPK70.78431069
76PIK3CA0.77727020
77ITK0.77557700
78FRK0.76975187
79DMPK0.74761762
80PRKD20.74243463
81CDK120.72941666
82PDGFRA0.72138259
83LCK0.71656707
84LYN0.70659892
85TRPM70.69544111
86TAOK20.69434026
87SCYL20.67866554
88MATK0.66716607
89CDC42BPA0.65710262
90PAK40.65141398
91MAP3K80.64403881
92PIK3CG0.61558772
93NUAK10.58236666
94KSR20.57101219
95MAP3K50.57017260
96PRKAA20.56877451
97PDPK10.56387671
98MARK20.55660667
99SIK20.54989856
100MTOR0.54956719
101MARK30.53874503
102TNK20.53217098
103MAP3K70.52971796
104RPS6KA60.52913923
105STK30.51845405
106TAOK10.51272486
107STK40.51121526
108ABL20.50528182
109CDK60.50006499
110CAMK1G0.49214315
111LATS20.48218044
112PAK20.47501720
113MAP3K130.47220593
114PTK20.46420449
115HIPK20.46215899
116MAPK40.45822731
117MAPKAPK20.45216909
118MET0.44998092
119RPS6KL10.44644439
120RPS6KC10.44644439
121DAPK30.43950482
122PDGFRB0.42580512
123EGFR0.41825930
124ILK0.41814963
125STK240.41484378
126PDK10.40863369
127RPS6KA20.40338365
128CLK10.39940350
129MAP2K60.37460353
130CDK40.35066720
131MAPK120.34892629
132FES0.31467890
133MELK0.29843113
134BRAF0.28204126
135MAP3K90.28007683

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.42685472
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.16208561
3Leishmaniasis_Homo sapiens_hsa051402.09405524
4Rheumatoid arthritis_Homo sapiens_hsa053232.04397567
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.02852077
6Caffeine metabolism_Homo sapiens_hsa002322.02383848
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.00985084
8Asthma_Homo sapiens_hsa053101.99673938
9Nitrogen metabolism_Homo sapiens_hsa009101.95211575
10Autoimmune thyroid disease_Homo sapiens_hsa053201.91977296
11Tryptophan metabolism_Homo sapiens_hsa003801.81513531
12Pentose and glucuronate interconversions_Homo sapiens_hsa000401.79970392
13Fatty acid degradation_Homo sapiens_hsa000711.77169806
14Arginine biosynthesis_Homo sapiens_hsa002201.72749577
15Complement and coagulation cascades_Homo sapiens_hsa046101.68143238
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.65606613
17Fat digestion and absorption_Homo sapiens_hsa049751.58531428
18African trypanosomiasis_Homo sapiens_hsa051431.58049432
19Type I diabetes mellitus_Homo sapiens_hsa049401.57689439
20* NF-kappa B signaling pathway_Homo sapiens_hsa040641.56237372
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.54923827
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.51963629
23Osteoclast differentiation_Homo sapiens_hsa043801.46886418
24* Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42736144
25Legionellosis_Homo sapiens_hsa051341.40547001
26Folate biosynthesis_Homo sapiens_hsa007901.38090313
27Antigen processing and presentation_Homo sapiens_hsa046121.37225356
28PPAR signaling pathway_Homo sapiens_hsa033201.36502829
29Other glycan degradation_Homo sapiens_hsa005111.35657802
30Bladder cancer_Homo sapiens_hsa052191.34263825
31Lysosome_Homo sapiens_hsa041421.34146334
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30447633
33Starch and sucrose metabolism_Homo sapiens_hsa005001.28450284
34Prion diseases_Homo sapiens_hsa050201.27667917
35Sulfur relay system_Homo sapiens_hsa041221.25863289
36B cell receptor signaling pathway_Homo sapiens_hsa046621.24227605
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21960328
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.21307070
39Sulfur metabolism_Homo sapiens_hsa009201.20001981
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18261000
41Toxoplasmosis_Homo sapiens_hsa051451.17894642
42Measles_Homo sapiens_hsa051621.16697522
43Tuberculosis_Homo sapiens_hsa051521.16046593
44Vitamin digestion and absorption_Homo sapiens_hsa049771.15706177
45Malaria_Homo sapiens_hsa051441.15199420
46Galactose metabolism_Homo sapiens_hsa000521.14850838
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.14293904
48Selenocompound metabolism_Homo sapiens_hsa004501.13718384
49Renin-angiotensin system_Homo sapiens_hsa046141.12083278
50* Pertussis_Homo sapiens_hsa051331.11388861
51Primary immunodeficiency_Homo sapiens_hsa053401.09961612
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07933029
53Chemokine signaling pathway_Homo sapiens_hsa040621.06811508
54Phagosome_Homo sapiens_hsa041451.05070643
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.04859309
56T cell receptor signaling pathway_Homo sapiens_hsa046601.00742204
57Peroxisome_Homo sapiens_hsa041461.00698710
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99594555
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.98710574
60Histidine metabolism_Homo sapiens_hsa003400.97991404
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97733472
62Fatty acid metabolism_Homo sapiens_hsa012120.97529522
63Hematopoietic cell lineage_Homo sapiens_hsa046400.95943075
64Lysine degradation_Homo sapiens_hsa003100.95479827
65Apoptosis_Homo sapiens_hsa042100.95450512
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95357915
67TNF signaling pathway_Homo sapiens_hsa046680.95313014
68* Influenza A_Homo sapiens_hsa051640.94402805
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93673093
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92954459
71Insulin resistance_Homo sapiens_hsa049310.92839100
72VEGF signaling pathway_Homo sapiens_hsa043700.89817821
73Pentose phosphate pathway_Homo sapiens_hsa000300.89276782
74Carbon metabolism_Homo sapiens_hsa012000.87644450
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87231007
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87140678
77ABC transporters_Homo sapiens_hsa020100.85182397
78Acute myeloid leukemia_Homo sapiens_hsa052210.83080956
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.82449743
80beta-Alanine metabolism_Homo sapiens_hsa004100.82078571
81Epstein-Barr virus infection_Homo sapiens_hsa051690.81212363
82Prolactin signaling pathway_Homo sapiens_hsa049170.80126931
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.79604340
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.79167677
85Notch signaling pathway_Homo sapiens_hsa043300.78132230
86Viral myocarditis_Homo sapiens_hsa054160.77697602
87Pancreatic cancer_Homo sapiens_hsa052120.77647938
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76313573
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76011505
90* Herpes simplex infection_Homo sapiens_hsa051680.75396510
91Bile secretion_Homo sapiens_hsa049760.75109991
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.73936860
93Chronic myeloid leukemia_Homo sapiens_hsa052200.72116907
94* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72011717
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69512947
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68251425
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67833424
98Biosynthesis of amino acids_Homo sapiens_hsa012300.67550094
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66800979
100HTLV-I infection_Homo sapiens_hsa051660.66207099
101Allograft rejection_Homo sapiens_hsa053300.66015695
102Shigellosis_Homo sapiens_hsa051310.65526120
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65502236
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64720844
105Chemical carcinogenesis_Homo sapiens_hsa052040.64459668
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64273772
107Amoebiasis_Homo sapiens_hsa051460.63251037
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.63120213
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62868789
110Sphingolipid metabolism_Homo sapiens_hsa006000.62582762
111Fructose and mannose metabolism_Homo sapiens_hsa000510.61820850
112* Hepatitis B_Homo sapiens_hsa051610.61609124
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59859134
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59289632
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58567067
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58171618
117Renal cell carcinoma_Homo sapiens_hsa052110.57647495
118Propanoate metabolism_Homo sapiens_hsa006400.56922469
119Salmonella infection_Homo sapiens_hsa051320.56389392
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56221602
121* Hepatitis C_Homo sapiens_hsa051600.55943706
122Graft-versus-host disease_Homo sapiens_hsa053320.55069736
123Non-small cell lung cancer_Homo sapiens_hsa052230.54416082
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53627106
125One carbon pool by folate_Homo sapiens_hsa006700.53572392
126Viral carcinogenesis_Homo sapiens_hsa052030.52667508
127Endocytosis_Homo sapiens_hsa041440.51446755
128Phenylalanine metabolism_Homo sapiens_hsa003600.50514888
129Small cell lung cancer_Homo sapiens_hsa052220.49941617
130Vibrio cholerae infection_Homo sapiens_hsa051100.46085147
131HIF-1 signaling pathway_Homo sapiens_hsa040660.44141733
132Type II diabetes mellitus_Homo sapiens_hsa049300.41405576
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40742903
134GnRH signaling pathway_Homo sapiens_hsa049120.37165307
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35019057
136Platelet activation_Homo sapiens_hsa046110.34744570
137Proteoglycans in cancer_Homo sapiens_hsa052050.34615187
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33794416
139Prostate cancer_Homo sapiens_hsa052150.33333328
140MAPK signaling pathway_Homo sapiens_hsa040100.33217339
141FoxO signaling pathway_Homo sapiens_hsa040680.33030396
142mTOR signaling pathway_Homo sapiens_hsa041500.31977242
143Insulin signaling pathway_Homo sapiens_hsa049100.30593106
144Phospholipase D signaling pathway_Homo sapiens_hsa040720.28695583
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.26712643
146ErbB signaling pathway_Homo sapiens_hsa040120.26395597

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