TICAM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of interleukin-12 production (GO:0032695)4.80231792
2positive regulation by symbiont of host defense response (GO:0052509)4.48213445
3modulation by symbiont of host defense response (GO:0052031)4.48213445
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.48213445
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.48213445
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.48213445
7modulation by symbiont of host immune response (GO:0052553)4.48213445
8neutrophil activation involved in immune response (GO:0002283)4.44440860
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.42420083
10response to peptidoglycan (GO:0032494)4.26178705
11positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.16833301
12superoxide anion generation (GO:0042554)4.11789533
13regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.07388833
14regulation of B cell receptor signaling pathway (GO:0050855)3.85200011
15neutrophil activation (GO:0042119)3.77178104
16regulation of T-helper 1 cell differentiation (GO:0045625)3.77035009
17detection of external biotic stimulus (GO:0098581)3.72839689
18positive regulation of antigen processing and presentation (GO:0002579)3.70480864
19lipopolysaccharide-mediated signaling pathway (GO:0031663)3.68563469
20myeloid leukocyte mediated immunity (GO:0002444)3.68309267
21immunoglobulin mediated immune response (GO:0016064)3.66624350
22detection of bacterium (GO:0016045)3.56320744
23regulation of vitamin D biosynthetic process (GO:0060556)3.55120916
24response to muramyl dipeptide (GO:0032495)3.54832859
25neutrophil mediated immunity (GO:0002446)3.52783476
26positive regulation of type 2 immune response (GO:0002830)3.50558466
27regulation of antigen processing and presentation (GO:0002577)3.49109350
28negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.48958684
29negative regulation of cell killing (GO:0031342)3.48958684
30regulation of T cell tolerance induction (GO:0002664)3.43956483
31granulocyte activation (GO:0036230)3.40933419
32regulation of interferon-beta biosynthetic process (GO:0045357)3.40411917
33respiratory burst (GO:0045730)3.39264693
34positive regulation of gamma-delta T cell activation (GO:0046645)3.38217176
35myeloid dendritic cell activation (GO:0001773)3.35502446
36regulation of mast cell activation (GO:0033003)3.31954863
37regulation of mast cell degranulation (GO:0043304)3.30456596
38defense response to protozoan (GO:0042832)3.29711413
39detection of biotic stimulus (GO:0009595)3.28229984
40germinal center formation (GO:0002467)3.25961521
41positive regulation of interferon-alpha production (GO:0032727)3.24706509
42regulation of tolerance induction (GO:0002643)3.24043337
43regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.22476588
44regulation of mononuclear cell migration (GO:0071675)3.18185360
45regulation of RIG-I signaling pathway (GO:0039535)3.17309063
46cellular response to zinc ion (GO:0071294)3.15951136
47regulation of B cell differentiation (GO:0045577)3.13462103
48positive regulation of natural killer cell differentiation (GO:0032825)3.11710650
49macrophage activation involved in immune response (GO:0002281)3.11654319
50regulation of interleukin-8 biosynthetic process (GO:0045414)3.09821423
51regulation of mast cell activation involved in immune response (GO:0033006)3.09440867
52response to host immune response (GO:0052572)3.08126108
53response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.08126108
54regulation of dendritic cell antigen processing and presentation (GO:0002604)3.07481149
55regulation of interferon-alpha production (GO:0032647)3.06523973
56regulation of T-helper 2 cell differentiation (GO:0045628)3.05744383
57cellular response to interferon-gamma (GO:0071346)3.05664576
58dendritic cell chemotaxis (GO:0002407)3.04489687
59positive regulation of chemokine biosynthetic process (GO:0045080)3.02210451
60negative regulation of mast cell activation (GO:0033004)3.01996880
61regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.00303153
62myeloid dendritic cell differentiation (GO:0043011)3.00186346
63response to protozoan (GO:0001562)2.98133707
64regulation of type 2 immune response (GO:0002828)2.97593594
65histamine secretion (GO:0001821)2.97572476
66positive regulation of mast cell activation (GO:0033005)2.94830122
67positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.93867363
68type I interferon signaling pathway (GO:0060337)2.92705926
69cellular response to type I interferon (GO:0071357)2.92705926
70positive regulation of mast cell activation involved in immune response (GO:0033008)2.91748197
71positive regulation of mast cell degranulation (GO:0043306)2.91748197
72detection of molecule of bacterial origin (GO:0032490)2.90740484
73production of molecular mediator involved in inflammatory response (GO:0002532)2.90562233
74response to interferon-gamma (GO:0034341)2.90383358
75regulation of interleukin-12 production (GO:0032655)2.87330903
76response to type I interferon (GO:0034340)2.87325779
77positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.86560511
78negative regulation of cytokine production involved in immune response (GO:0002719)2.85096123
79regulation of chemokine biosynthetic process (GO:0045073)2.84793589
80regulation of activation of Janus kinase activity (GO:0010533)2.84511323
81regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.84210467
82negative regulation of granulocyte differentiation (GO:0030853)2.82908861
83positive regulation of macrophage cytokine production (GO:0060907)2.82745007
84positive regulation of tolerance induction (GO:0002645)2.81801702
85microglial cell activation (GO:0001774)2.81584837
86regulation of cytokine secretion involved in immune response (GO:0002739)2.81272106
87lymphocyte chemotaxis (GO:0048247)2.80881335
88cellular extravasation (GO:0045123)2.80703325
89positive regulation of B cell differentiation (GO:0045579)2.80040127
90myeloid cell activation involved in immune response (GO:0002275)2.79853028
91regulation of monocyte chemotaxis (GO:0090025)2.79484355
92detection of other organism (GO:0098543)2.79458430
93response to interferon-alpha (GO:0035455)2.79273418
94* positive regulation of interleukin-6 production (GO:0032755)2.78600822
95regulation of podosome assembly (GO:0071801)2.78354344
96response to host (GO:0075136)2.78110956
97response to host defenses (GO:0052200)2.78110956
98response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.78110956
99interferon-gamma-mediated signaling pathway (GO:0060333)2.77447390
100positive regulation of NF-kappaB import into nucleus (GO:0042346)2.77345261
101dendritic cell migration (GO:0036336)2.77295963
102cellular response to interferon-alpha (GO:0035457)2.76344714
103regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.75620883
104antigen processing and presentation of endogenous antigen (GO:0019883)2.75461434
105positive regulation of interferon-beta production (GO:0032728)2.74926444
106dendritic cell differentiation (GO:0097028)2.74302430
107antigen processing and presentation via MHC class Ib (GO:0002475)2.74236708
108B cell mediated immunity (GO:0019724)2.72749841
109positive regulation of macrophage differentiation (GO:0045651)2.72452840
110regulation of vitamin metabolic process (GO:0030656)2.71134344
111positive regulation of cellular amide metabolic process (GO:0034250)2.70663633
112macrophage activation (GO:0042116)2.70611201
113positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.70191221
114positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.70113376
115positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.70070972
116response to interferon-beta (GO:0035456)2.69780892
117DNA deamination (GO:0045006)2.69131365
118regulation of macrophage cytokine production (GO:0010935)2.68961627
119regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.67874691
120NIK/NF-kappaB signaling (GO:0038061)2.67854357
121interferon-gamma production (GO:0032609)2.66739473
122leukocyte aggregation (GO:0070486)2.66597760
123cellular response to interferon-beta (GO:0035458)2.65736265
124positive regulation of T cell migration (GO:2000406)2.65302624
125negative regulation of myeloid cell apoptotic process (GO:0033033)2.64625100
126myeloid leukocyte activation (GO:0002274)2.64190624
127positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.61406491
128positive regulation of interleukin-12 production (GO:0032735)2.60629967
129* positive regulation of interferon-gamma production (GO:0032729)2.59472471
130regulation of cellular extravasation (GO:0002691)2.59463722
131natural killer cell activation involved in immune response (GO:0002323)2.58665859
132B cell homeostasis (GO:0001782)2.56851014
133antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.55497833
134antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.55497833
135regulation of chemokine-mediated signaling pathway (GO:0070099)2.53171676
136positive regulation of T cell chemotaxis (GO:0010820)2.53038180
137regulation of T cell chemotaxis (GO:0010819)2.53038180
138positive regulation of interleukin-1 beta secretion (GO:0050718)2.52541315
139positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.52335164
140positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.50887493
141B cell receptor signaling pathway (GO:0050853)2.49261242
142regulation of myeloid leukocyte mediated immunity (GO:0002886)2.46567137
143T-helper 1 type immune response (GO:0042088)2.45415770
144mast cell activation (GO:0045576)2.45373074
145positive regulation of interleukin-10 production (GO:0032733)2.44372344

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.49171007
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.36495195
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.22139757
4E2F7_22180533_ChIP-Seq_HELA_Human4.28138099
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.24709110
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.55645323
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.23171715
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.21910438
9* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.20161120
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.19189359
11ELF1_17652178_ChIP-ChIP_JURKAT_Human3.08644798
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.97627177
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.67192190
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.60078151
15* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53836143
16SCL_19346495_ChIP-Seq_HPC-7_Human2.43448364
17* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.42929198
18FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.38428302
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.38166629
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.38072958
21* SPI1_23547873_ChIP-Seq_NB4_Human2.37679689
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.35851169
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.34804914
24* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.26476984
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.04211389
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.04088465
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.97741799
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.93879662
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.93272448
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.92426607
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83584478
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.83173007
33MYB_26560356_Chip-Seq_TH2_Human1.80850633
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.76341526
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75852492
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.74452046
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73237625
38SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.70984881
39RUNX_20019798_ChIP-Seq_JUKART_Human1.68534250
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66558478
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64962705
42CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.61810889
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.59767264
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.59650036
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54276211
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54135482
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52310220
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.51337756
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50768529
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.50694600
51CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.50055145
52FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49268655
53MYB_26560356_Chip-Seq_TH1_Human1.49227578
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.45814663
55CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45692478
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.45518444
57* BRD4_25478319_ChIP-Seq_HGPS_Human1.44205752
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42679256
59* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41469499
60GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.41068170
61TRIM28_21343339_ChIP-Seq_HEK293_Human1.41015031
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39988330
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38545614
64VDR_24763502_ChIP-Seq_THP-1_Human1.38492909
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.38413041
66PU_27001747_Chip-Seq_BMDM_Mouse1.38263883
67* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36412358
68NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.35137103
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34646513
70* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33709506
71ELK1_19687146_ChIP-ChIP_HELA_Human1.33633418
72JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33491729
73CJUN_26792858_Chip-Seq_BT549_Human1.32856635
74RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30916240
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30464909
76JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30094109
77GABP_17652178_ChIP-ChIP_JURKAT_Human1.29987677
78JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29446307
79FLI1_27457419_Chip-Seq_LIVER_Mouse1.28731513
80VDR_23849224_ChIP-Seq_CD4+_Human1.26201946
81GATA1_22025678_ChIP-Seq_K562_Human1.26049620
82SPI1_23127762_ChIP-Seq_K562_Human1.25106756
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22855231
84TFEB_21752829_ChIP-Seq_HELA_Human1.21784735
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19241320
86FOXP3_21729870_ChIP-Seq_TREG_Human1.18542817
87RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17439791
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.14609935
89SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13809963
90SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13809963
91VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13561508
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13367451
93CIITA_25753668_ChIP-Seq_RAJI_Human1.12407920
94VDR_24787735_ChIP-Seq_THP-1_Human1.07181491
95* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07026527
96SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06029312
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05370466
98VDR_21846776_ChIP-Seq_THP-1_Human1.05232396
99MAF_26560356_Chip-Seq_TH1_Human1.04973016
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04783903
101TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04501428
102NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04139360
103NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04139360
104SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02810920
105CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02370080
106ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01692846
107* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01080939
108ELK3_25401928_ChIP-Seq_HUVEC_Human1.00873712
109CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00286653
110WT1_19549856_ChIP-ChIP_CCG9911_Human0.99479839
111E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98060179
112SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97741845
113STAT3_18555785_Chip-Seq_ESCs_Mouse0.96543104
114RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93281927
115YY1_21170310_ChIP-Seq_MESCs_Mouse0.92937634
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92426592
117GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92051417
118ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91597146
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90996394
120EZH2_27294783_Chip-Seq_NPCs_Mouse0.90975115
121RUNX1_27457419_Chip-Seq_LIVER_Mouse0.90936714
122FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.90884835
123IGF1R_20145208_ChIP-Seq_DFB_Human0.89295709
124NMYC_18555785_Chip-Seq_ESCs_Mouse0.87281222
125SOX2_20726797_ChIP-Seq_SW620_Human0.87137488
126GATA3_27048872_Chip-Seq_THYMUS_Human0.85956400
127GATA3_26560356_Chip-Seq_TH2_Human0.85469923
128IKZF1_21737484_ChIP-ChIP_HCT116_Human0.84897202
129CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82642114
130SUZ12_18555785_Chip-Seq_ESCs_Mouse0.82309100
131FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82154905
132SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.80819685
133ZFX_18555785_Chip-Seq_ESCs_Mouse0.80397854
134P53_22387025_ChIP-Seq_ESCs_Mouse0.80277492
135UTX_26944678_Chip-Seq_JUKART_Human0.79053471
136PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78485078
137TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.78022733
138STAT1_20625510_ChIP-Seq_HELA_Human0.74570695
139KDM2B_26808549_Chip-Seq_SUP-B15_Human0.73206763
140EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.73060076
141SMC1_22415368_ChIP-Seq_MEFs_Mouse0.70633056
142TBX20_22080862_ChIP-Seq_HEART_Mouse0.69020133
143TBX20_22328084_ChIP-Seq_HEART_Mouse0.69020133

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.53799526
2MP0005671_abnormal_response_to3.57572594
3MP0009785_altered_susceptibility_to3.23265125
4MP0002148_abnormal_hypersensitivity_rea3.15088548
5MP0002419_abnormal_innate_immunity2.86823188
6MP0005000_abnormal_immune_tolerance2.86545986
7MP0000015_abnormal_ear_pigmentation2.78455906
8MP0003436_decreased_susceptibility_to2.76331785
9MP0003724_increased_susceptibility_to2.75461270
10MP0005174_abnormal_tail_pigmentation2.75169192
11MP0005025_abnormal_response_to2.67520841
12* MP0001790_abnormal_immune_system2.67202519
13* MP0005387_immune_system_phenotype2.67202519
14MP0001800_abnormal_humoral_immune2.64865183
15MP0002452_abnormal_antigen_presenting2.64814527
16MP0008438_abnormal_cutaneous_collagen2.50681859
17MP0003300_gastrointestinal_ulcer2.49109932
18* MP0002723_abnormal_immune_serum2.46782885
19MP0001819_abnormal_immune_cell2.44301649
20MP0002420_abnormal_adaptive_immunity2.44287342
21MP0003191_abnormal_cellular_cholesterol2.33118243
22MP0002277_abnormal_respiratory_mucosa2.31477003
23MP0000685_abnormal_immune_system2.27736623
24MP0005075_abnormal_melanosome_morpholog2.17192992
25MP0002396_abnormal_hematopoietic_system2.12001280
26MP0008057_abnormal_DNA_replication2.08933217
27MP0000569_abnormal_digit_pigmentation2.05283334
28MP0003075_altered_response_to1.96572342
29MP0006054_spinal_hemorrhage1.93302918
30MP0002398_abnormal_bone_marrow1.92297375
31MP0000716_abnormal_immune_system1.87934604
32MP0005464_abnormal_platelet_physiology1.83446073
33MP0006082_CNS_inflammation1.82901608
34MP0002405_respiratory_system_inflammati1.80875365
35MP0003763_abnormal_thymus_physiology1.75659486
36MP0002332_abnormal_exercise_endurance1.74473379
37MP0001853_heart_inflammation1.74395257
38MP0003172_abnormal_lysosome_physiology1.73633110
39MP0001542_abnormal_bone_strength1.71104795
40MP0004381_abnormal_hair_follicle1.69119492
41MP0005451_abnormal_body_composition1.68768431
42MP0008058_abnormal_DNA_repair1.66502291
43MP0003950_abnormal_plasma_membrane1.62777408
44MP0003091_abnormal_cell_migration1.62557976
45MP0002095_abnormal_skin_pigmentation1.60321640
46MP0008004_abnormal_stomach_pH1.57919693
47MP0001845_abnormal_inflammatory_respons1.57610593
48MP0009840_abnormal_foam_cell1.56834572
49MP0009333_abnormal_splenocyte_physiolog1.56382623
50MP0000689_abnormal_spleen_morphology1.55311362
51MP0004782_abnormal_surfactant_physiolog1.55053178
52MP0002429_abnormal_blood_cell1.54417915
53MP0005164_abnormal_response_to1.54164310
54MP0010155_abnormal_intestine_physiology1.52982518
55MP0003279_aneurysm1.51936418
56MP0002006_tumorigenesis1.49027980
57MP0002722_abnormal_immune_system1.46875737
58MP0006292_abnormal_olfactory_placode1.46444786
59MP0008260_abnormal_autophagy1.43492501
60MP0004883_abnormal_blood_vessel1.40283251
61MP0001958_emphysema1.37036697
62MP0003806_abnormal_nucleotide_metabolis1.35972255
63MP0000371_diluted_coat_color1.34772983
64MP0005166_decreased_susceptibility_to1.34530536
65MP0005310_abnormal_salivary_gland1.34368896
66MP0003705_abnormal_hypodermis_morpholog1.34111751
67MP0002933_joint_inflammation1.32496518
68MP0000566_synostosis1.32379701
69MP0001533_abnormal_skeleton_physiology1.31717298
70MP0003693_abnormal_embryo_hatching1.31524311
71MP0009764_decreased_sensitivity_to1.31214208
72MP0000490_abnormal_crypts_of1.28679089
73MP0002166_altered_tumor_susceptibility1.27486565
74MP0008469_abnormal_protein_level1.25263940
75MP0002132_abnormal_respiratory_system1.24773227
76MP0008007_abnormal_cellular_replicative1.24155536
77MP0001188_hyperpigmentation1.24106305
78MP0003183_abnormal_peptide_metabolism1.22711443
79MP0003448_altered_tumor_morphology1.21461462
80MP0001873_stomach_inflammation1.19133782
81MP0005058_abnormal_lysosome_morphology1.17742048
82MP0000858_altered_metastatic_potential1.17549506
83MP0000465_gastrointestinal_hemorrhage1.16499727
84MP0003303_peritoneal_inflammation1.15464708
85MP0001986_abnormal_taste_sensitivity1.13176457
86MP0005023_abnormal_wound_healing1.08070938
87MP0004808_abnormal_hematopoietic_stem1.07622150
88MP0000703_abnormal_thymus_morphology1.06171260
89MP0003828_pulmonary_edema1.04705024
90MP0005275_abnormal_skin_tensile1.04569894
91MP0000604_amyloidosis1.03814718
92MP0000343_altered_response_to1.00803842
93MP0002998_abnormal_bone_remodeling0.99891325
94MP0005397_hematopoietic_system_phenotyp0.98911426
95MP0001545_abnormal_hematopoietic_system0.98911426
96MP0010094_abnormal_chromosome_stability0.96908044
97MP0001186_pigmentation_phenotype0.96775035
98MP0004947_skin_inflammation0.96274051
99MP0009763_increased_sensitivity_to0.96173075
100MP0003195_calcinosis0.93907383
101MP0002075_abnormal_coat/hair_pigmentati0.92166945
102MP0003690_abnormal_glial_cell0.91043080
103MP0005165_increased_susceptibility_to0.88401390
104MP0003656_abnormal_erythrocyte_physiolo0.88277896
105MP0005171_absent_coat_pigmentation0.87421945
106MP0000767_abnormal_smooth_muscle0.86625439
107MP0003795_abnormal_bone_structure0.86360448
108MP0003453_abnormal_keratinocyte_physiol0.86096865
109MP0003566_abnormal_cell_adhesion0.84886193
110MP0000372_irregular_coat_pigmentation0.84501336
111MP0010386_abnormal_urinary_bladder0.83737889
112MP0009697_abnormal_copulation0.82366851
113MP0005390_skeleton_phenotype0.82018217
114MP0002254_reproductive_system_inflammat0.81548222
115MP0009278_abnormal_bone_marrow0.80431410
116MP0002877_abnormal_melanocyte_morpholog0.76444307
117MP0003045_fibrosis0.75118012
118MP0005409_darkened_coat_color0.73434360
119MP0003866_abnormal_defecation0.72700033
120MP0010352_gastrointestinal_tract_polyps0.72202473
121MP0005645_abnormal_hypothalamus_physiol0.72067533
122MP0003111_abnormal_nucleus_morphology0.71448743
123MP0003077_abnormal_cell_cycle0.70951078
124MP0003186_abnormal_redox_activity0.70667482
125MP0002295_abnormal_pulmonary_circulatio0.70343707
126MP0002139_abnormal_hepatobiliary_system0.69852478
127MP0000681_abnormal_thyroid_gland0.69526694
128MP0008995_early_reproductive_senescence0.69181083
129MP0000749_muscle_degeneration0.68330159
130MP0005257_abnormal_intraocular_pressure0.68224915
131MP0002009_preneoplasia0.68085313
132MP0009765_abnormal_xenobiotic_induced0.67804498
133MP0003786_premature_aging0.67272607
134MP0001851_eye_inflammation0.67158588
135MP0005379_endocrine/exocrine_gland_phen0.67147850
136MP0004510_myositis0.65485244
137MP0001663_abnormal_digestive_system0.64925677
138MP0005595_abnormal_vascular_smooth0.63778981
139MP0000313_abnormal_cell_death0.63291292
140MP0002693_abnormal_pancreas_physiology0.61765066
141MP0001243_abnormal_dermal_layer0.61590601
142MP0002019_abnormal_tumor_incidence0.59997682
143MP0000249_abnormal_blood_vessel0.53441226
144MP0003787_abnormal_imprinting0.53400950

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.50178318
2Recurrent bacterial skin infections (HP:0005406)4.67477800
3Eczematoid dermatitis (HP:0000976)4.58368827
4Myositis (HP:0100614)4.52105000
5Optic neuritis (HP:0100653)4.33577587
6Retrobulbar optic neuritis (HP:0100654)4.33577587
7Mediastinal lymphadenopathy (HP:0100721)4.14402548
8Orchitis (HP:0100796)3.96112795
9Peritonitis (HP:0002586)3.67664069
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.67387291
11Elevated erythrocyte sedimentation rate (HP:0003565)3.65587057
12Recurrent gram-negative bacterial infections (HP:0005420)3.59049863
13Obstructive lung disease (HP:0006536)3.56059863
14Chronic obstructive pulmonary disease (HP:0006510)3.56059863
15Gastrointestinal infarctions (HP:0005244)3.48391313
16Abnormality of macrophages (HP:0004311)3.47611685
17Loss of speech (HP:0002371)3.41694227
18Chromsome breakage (HP:0040012)3.34275290
19Meningitis (HP:0001287)3.29611388
20Gingivitis (HP:0000230)3.29420396
21IgM deficiency (HP:0002850)3.27054370
22Prostate neoplasm (HP:0100787)3.20353606
23Recurrent pneumonia (HP:0006532)3.19600971
24Dysostosis multiplex (HP:0000943)3.19013824
25Amyloidosis (HP:0011034)3.08885311
26Recurrent fungal infections (HP:0002841)2.99778767
27Myocardial infarction (HP:0001658)2.98374173
28Vacuolated lymphocytes (HP:0001922)2.97727767
29Spondylolisthesis (HP:0003302)2.90804057
30Recurrent skin infections (HP:0001581)2.86887543
31Albinism (HP:0001022)2.73618295
32Vasculitis (HP:0002633)2.71985325
33Reduced antithrombin III activity (HP:0001976)2.67666610
34Recurrent viral infections (HP:0004429)2.67054236
35Abnormality of glycosaminoglycan metabolism (HP:0004371)2.66584202
36Abnormality of mucopolysaccharide metabolism (HP:0011020)2.66584202
37Abnormality of polysaccharide metabolism (HP:0011012)2.66584202
38Abnormality of the prostate (HP:0008775)2.64692472
39Disinhibition (HP:0000734)2.62342130
40Urinary glycosaminoglycan excretion (HP:0003541)2.62106910
41Mucopolysacchariduria (HP:0008155)2.62106910
42Type I transferrin isoform profile (HP:0003642)2.61353875
43Petechiae (HP:0000967)2.60872185
44Recurrent lower respiratory tract infections (HP:0002783)2.57863394
45Pulmonary infiltrates (HP:0002113)2.56811377
46Progressive neurologic deterioration (HP:0002344)2.56726700
47Keratoconjunctivitis sicca (HP:0001097)2.53018832
48Periodontitis (HP:0000704)2.51467458
49Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.50438666
50Abnormal protein N-linked glycosylation (HP:0012347)2.50438666
51Abnormal protein glycosylation (HP:0012346)2.50438666
52Abnormal glycosylation (HP:0012345)2.50438666
53Hematochezia (HP:0002573)2.49764078
54Systemic lupus erythematosus (HP:0002725)2.48591184
55Episodic fever (HP:0001954)2.46219024
56Premature rupture of membranes (HP:0001788)2.43655121
57Agammaglobulinemia (HP:0004432)2.42623623
58Arterial thrombosis (HP:0004420)2.39236158
59Chronic mucocutaneous candidiasis (HP:0002728)2.38989415
60Recurrent cutaneous fungal infections (HP:0011370)2.38989415
61Stomatitis (HP:0010280)2.36656502
62Cheilitis (HP:0100825)2.34840723
63Cellulitis (HP:0100658)2.32089662
64Keratoconjunctivitis (HP:0001096)2.30975862
65Increased cerebral lipofuscin (HP:0011813)2.29887644
66Abnormal delayed hypersensitivity skin test (HP:0002963)2.29329569
67T lymphocytopenia (HP:0005403)2.28915275
68Encephalitis (HP:0002383)2.28811850
69Abnormality of T cell physiology (HP:0011840)2.24970537
70Nuclear cataract (HP:0100018)2.23996852
71Pulmonary fibrosis (HP:0002206)2.23851293
72Type 1 muscle fiber predominance (HP:0003803)2.23448959
73Granulocytopenia (HP:0001913)2.23338927
74Gangrene (HP:0100758)2.22930399
75Chest pain (HP:0100749)2.22441003
76Prolonged bleeding time (HP:0003010)2.22198998
77Gingival bleeding (HP:0000225)2.22086386
78Clubbing of toes (HP:0100760)2.21184001
79Urticaria (HP:0001025)2.20114507
80Vertebral compression fractures (HP:0002953)2.19172936
81Fatigue (HP:0012378)2.19135549
82Birth length less than 3rd percentile (HP:0003561)2.18811863
83Abnormality of T cell number (HP:0011839)2.18610046
84Hemoptysis (HP:0002105)2.18236171
85Eosinophilia (HP:0001880)2.18192181
86Basal ganglia calcification (HP:0002135)2.17698335
87Asymmetric septal hypertrophy (HP:0001670)2.17412055
88Poor head control (HP:0002421)2.16737752
89Inflammation of the large intestine (HP:0002037)2.16696728
90Dilatation of the ascending aorta (HP:0005111)2.16003768
91Abnormality of the peritoneum (HP:0002585)2.15725874
92Chronic diarrhea (HP:0002028)2.14148797
93Abnormality of the renal collecting system (HP:0004742)2.12196984
94Aortic aneurysm (HP:0004942)2.11198414
95Nemaline bodies (HP:0003798)2.10929289
96Chronic otitis media (HP:0000389)2.08448503
97Thin bony cortex (HP:0002753)2.07065439
98IgG deficiency (HP:0004315)2.06692154
99Increased serum ferritin (HP:0003281)2.06539505
100White forelock (HP:0002211)2.05824917
101Abnormality of the pericardium (HP:0001697)2.05558428
102Thrombocytosis (HP:0001894)2.05049600
103Hepatosplenomegaly (HP:0001433)2.05021496
104Osteomyelitis (HP:0002754)2.04807469
105Aplastic anemia (HP:0001915)2.04546686
106Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.04414794
107Patchy hypopigmentation of hair (HP:0011365)2.03436765
108Glomerulopathy (HP:0100820)2.03285687
109Malnutrition (HP:0004395)2.02684991
110Leukocytosis (HP:0001974)2.02450626
111Increased IgM level (HP:0003496)2.00895578
112Abnormality of the pleura (HP:0002103)2.00690587
113Muscle fiber inclusion bodies (HP:0100299)1.99172345
114Abnormality of glycolipid metabolism (HP:0010969)1.98944031
115Abnormality of liposaccharide metabolism (HP:0010968)1.98944031
116Abnormality of glycosphingolipid metabolism (HP:0004343)1.98944031
117Gastrointestinal inflammation (HP:0004386)1.98879119
118Duplicated collecting system (HP:0000081)1.98829295
119Lymphoma (HP:0002665)1.98786659
120Aplasia/Hypoplasia of the uvula (HP:0010293)1.98251338
121Lymphopenia (HP:0001888)1.97361665
122Axonal loss (HP:0003447)1.96895012
123Protrusio acetabuli (HP:0003179)1.96882444
124Neutropenia (HP:0001875)1.95235637
125Polyneuropathy (HP:0001271)1.94582122
126Panhypogammaglobulinemia (HP:0003139)1.93580174
127Osteolytic defects of the hand bones (HP:0009699)1.93280858
128Osteolytic defects of the phalanges of the hand (HP:0009771)1.93280858
129Abnormality of cells of the lymphoid lineage (HP:0012140)1.92985461
130Pustule (HP:0200039)1.92294515
131Reticulocytopenia (HP:0001896)1.92040440
132Leukopenia (HP:0001882)1.91806629
133Abnormality of eosinophils (HP:0001879)1.91597148
134Glomerulonephritis (HP:0000099)1.91168366
135Recurrent bronchitis (HP:0002837)1.90620086
136Hypothermia (HP:0002045)1.90481283
137Bone marrow hypocellularity (HP:0005528)1.89135281
138Spontaneous hematomas (HP:0007420)1.87721234
139Hypertensive crisis (HP:0100735)1.87557576
140Acne (HP:0001061)1.86480345
141Recurrent sinusitis (HP:0011108)1.86269774
142Aortic dissection (HP:0002647)1.86079961
143Abnormality of DNA repair (HP:0003254)1.86005523
144Abnormality of the vasculature of the conjunctiva (HP:0008054)1.85831353
145Abnormality of T cells (HP:0002843)1.85217257
146Polycythemia (HP:0001901)1.84871548
147Aplasia cutis congenita (HP:0001057)1.84283469
148Spinal cord lesions (HP:0100561)1.84028579
149Syringomyelia (HP:0003396)1.84028579
150Pulmonary embolism (HP:0002204)1.83550433
151Autoimmune thrombocytopenia (HP:0001973)1.83191529
152Vertigo (HP:0002321)1.82459757
153Vascular tortuosity (HP:0004948)1.82397727
154Abnormality of the preputium (HP:0100587)1.80212003
155Abnormal hair whorl (HP:0010721)1.79487460
156B lymphocytopenia (HP:0010976)1.78542288
157Abnormality of B cell number (HP:0010975)1.78542288
158Anorexia (HP:0002039)1.78150994

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK44.01276308
2IRAK33.70837135
3MAP3K143.35171341
4STK162.79235213
5BLK2.73872134
6SIK32.48715793
7TXK2.41323952
8MOS2.40411635
9DDR22.31448412
10ZAK2.28292786
11MAP4K12.23799581
12KIT2.21477851
13MAP2K32.19607170
14TAOK31.94545946
15IKBKB1.93559322
16IKBKE1.90343249
17TYK21.84815809
18MAP3K31.83184485
19TBK11.82132415
20FGR1.78984938
21JAK31.78977011
22CSF1R1.74289827
23BTK1.71852364
24RIPK41.70149936
25TEC1.67464467
26BMPR21.66293451
27MYLK1.64127878
28TAOK11.55876517
29EIF2AK31.55393475
30BRD41.55362617
31EIF2AK21.50666737
32YES11.38270136
33SYK1.33148773
34TTN1.31280432
35IRAK11.30052423
36MAP3K131.29350476
37PIM21.25991456
38CASK1.25859088
39TGFBR21.24536356
40CDC42BPA1.23697599
41JAK21.23567074
42LYN1.23216764
43CHUK1.21561798
44ADRBK21.20694587
45VRK11.17532713
46TNIK1.16779474
47TLK11.14284044
48GRK11.13444207
49PLK41.10897253
50TAOK21.10108552
51NME21.04134688
52HCK1.03790429
53MAP3K11.01721000
54CLK11.01663827
55LCK1.00633415
56ZAP700.99929380
57SRPK10.98174695
58IRAK20.97724348
59RIPK10.96815984
60MST40.92851006
61EPHB10.91318226
62FES0.91295102
63LIMK10.88319464
64INSRR0.88042465
65DYRK30.84263323
66TSSK60.83847332
67EIF2AK10.83727396
68GRK70.83470014
69MAP3K110.83275524
70PIM10.82934804
71PAK40.79913162
72STK40.79744754
73ITK0.78174862
74FGFR40.78135425
75NEK60.77902584
76MATK0.77864480
77NLK0.77860773
78BMPR1B0.77531912
79MAP2K70.76914137
80PIK3CG0.76790175
81EPHA30.76156790
82CSK0.76130601
83PTK2B0.74615099
84ATR0.73662836
85PDGFRA0.72355930
86MAPK70.71811804
87ABL20.71743109
88RPS6KA40.69978922
89TRPM70.68511482
90CDK80.68040389
91ERN10.67438124
92ERBB30.66996307
93FGFR30.66522551
94FLT30.66258136
95MKNK10.65158145
96KSR20.64965306
97OBSCN0.63581171
98TNK20.63053371
99STK100.62936531
100ROCK20.62639720
101PRKD20.62338246
102JAK10.62260219
103DMPK0.62021276
104CDK120.59179687
105PRKG20.57318481
106ARAF0.57238376
107MARK30.56401082
108PASK0.54317400
109CDK30.54124484
110PDK10.54084577
111PDPK10.53225607
112ACVR1B0.53088376
113TESK10.52848283
114CCNB10.51504804
115ILK0.50835455
116PRKCD0.50498287
117MKNK20.49509768
118HIPK20.48083424
119RPS6KA60.46850519
120RAF10.46843870
121MAP3K120.46770311
122MAPK130.46642308
123KSR10.45828219
124NEK90.45797337
125PDGFRB0.45168352
126CDK60.44754965
127RPS6KC10.44150532
128RPS6KL10.44150532
129ROCK10.43033545
130FRK0.42998520
131MAP2K60.42531757
132EGFR0.41881792
133LATS20.41818630
134MAPKAPK20.41297951
135PAK10.40007514
136PRPF4B0.39651150
137STK380.39019735
138CDK70.38405650
139MAP3K50.38028029
140MAP3K20.37220355
141MAPK120.36136839
142MELK0.36083389
143CDK90.36060280
144PBK0.35734926
145MUSK0.34975591
146STK240.34302956
147ABL10.32700843

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.06364091
2Leishmaniasis_Homo sapiens_hsa051402.42018133
3* NF-kappa B signaling pathway_Homo sapiens_hsa040642.36299585
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.32979896
5Graft-versus-host disease_Homo sapiens_hsa053322.14465000
6Other glycan degradation_Homo sapiens_hsa005112.10759071
7Primary immunodeficiency_Homo sapiens_hsa053402.08996677
8Measles_Homo sapiens_hsa051622.07054156
9* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.06562425
10Fanconi anemia pathway_Homo sapiens_hsa034602.00250587
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.98522674
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96616094
13DNA replication_Homo sapiens_hsa030301.96036598
14Allograft rejection_Homo sapiens_hsa053301.93804236
15Homologous recombination_Homo sapiens_hsa034401.89406028
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.87866658
17Legionellosis_Homo sapiens_hsa051341.80100843
18Staphylococcus aureus infection_Homo sapiens_hsa051501.78031190
19Base excision repair_Homo sapiens_hsa034101.74877523
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.73512400
21Herpes simplex infection_Homo sapiens_hsa051681.70385098
22Hematopoietic cell lineage_Homo sapiens_hsa046401.62694725
23Osteoclast differentiation_Homo sapiens_hsa043801.61192450
24* Pertussis_Homo sapiens_hsa051331.53527685
25Tuberculosis_Homo sapiens_hsa051521.51476162
26Malaria_Homo sapiens_hsa051441.50308583
27Rheumatoid arthritis_Homo sapiens_hsa053231.48997414
28Influenza A_Homo sapiens_hsa051641.47067142
29Antigen processing and presentation_Homo sapiens_hsa046121.43984572
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.38889005
31RNA polymerase_Homo sapiens_hsa030201.36991752
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.35760865
33Non-homologous end-joining_Homo sapiens_hsa034501.35275809
34B cell receptor signaling pathway_Homo sapiens_hsa046621.33924681
35Asthma_Homo sapiens_hsa053101.29701494
36Mismatch repair_Homo sapiens_hsa034301.29380937
37Proteasome_Homo sapiens_hsa030501.28437724
38Lysosome_Homo sapiens_hsa041421.24049657
39TNF signaling pathway_Homo sapiens_hsa046681.23454005
40Autoimmune thyroid disease_Homo sapiens_hsa053201.23050543
41Pyrimidine metabolism_Homo sapiens_hsa002401.15407782
42Protein export_Homo sapiens_hsa030601.14020561
43Amoebiasis_Homo sapiens_hsa051461.13713566
44Phagosome_Homo sapiens_hsa041451.13328639
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09596993
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07535669
47Type I diabetes mellitus_Homo sapiens_hsa049401.06471992
48Apoptosis_Homo sapiens_hsa042101.06227655
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.06174835
50Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05294720
51Spliceosome_Homo sapiens_hsa030401.03064257
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01139216
53Chemokine signaling pathway_Homo sapiens_hsa040620.99905551
54Shigellosis_Homo sapiens_hsa051310.99888894
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99183773
56Epstein-Barr virus infection_Homo sapiens_hsa051690.98396438
57Salmonella infection_Homo sapiens_hsa051320.95865989
58Toxoplasmosis_Homo sapiens_hsa051450.93911107
59Notch signaling pathway_Homo sapiens_hsa043300.93148546
60* Hepatitis B_Homo sapiens_hsa051610.90708062
61Basal transcription factors_Homo sapiens_hsa030220.90393594
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90204544
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89926203
64RNA degradation_Homo sapiens_hsa030180.88813207
65African trypanosomiasis_Homo sapiens_hsa051430.87182887
66Ribosome_Homo sapiens_hsa030100.83257238
67Sphingolipid metabolism_Homo sapiens_hsa006000.82932668
68T cell receptor signaling pathway_Homo sapiens_hsa046600.78429606
69Nucleotide excision repair_Homo sapiens_hsa034200.76253655
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75914929
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74380397
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73235151
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69250870
74p53 signaling pathway_Homo sapiens_hsa041150.68067207
75Cell cycle_Homo sapiens_hsa041100.66379257
76One carbon pool by folate_Homo sapiens_hsa006700.65468854
77Viral myocarditis_Homo sapiens_hsa054160.64541447
78Prolactin signaling pathway_Homo sapiens_hsa049170.63888191
79Platelet activation_Homo sapiens_hsa046110.62699986
80Complement and coagulation cascades_Homo sapiens_hsa046100.62406368
81Purine metabolism_Homo sapiens_hsa002300.61154948
82Arachidonic acid metabolism_Homo sapiens_hsa005900.60898714
83Hepatitis C_Homo sapiens_hsa051600.60647292
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.59972872
85Acute myeloid leukemia_Homo sapiens_hsa052210.58513391
86Collecting duct acid secretion_Homo sapiens_hsa049660.57958531
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.55093339
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54362625
89Bladder cancer_Homo sapiens_hsa052190.54074623
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53784841
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53575469
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51912700
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.51689775
94Prion diseases_Homo sapiens_hsa050200.51331482
95N-Glycan biosynthesis_Homo sapiens_hsa005100.51236328
96Vibrio cholerae infection_Homo sapiens_hsa051100.50685268
97Endocytosis_Homo sapiens_hsa041440.50120790
98Sulfur metabolism_Homo sapiens_hsa009200.49762425
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48957416
100HTLV-I infection_Homo sapiens_hsa051660.48667286
101Focal adhesion_Homo sapiens_hsa045100.48121570
102Dorso-ventral axis formation_Homo sapiens_hsa043200.48098401
103Proteoglycans in cancer_Homo sapiens_hsa052050.48090858
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47940294
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45879167
106Pancreatic cancer_Homo sapiens_hsa052120.43681744
107Renal cell carcinoma_Homo sapiens_hsa052110.43193152
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41312969
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41224012
110Viral carcinogenesis_Homo sapiens_hsa052030.40501903
111Systemic lupus erythematosus_Homo sapiens_hsa053220.39624567
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38370872
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.37768005
114Regulation of autophagy_Homo sapiens_hsa041400.37499583
115HIF-1 signaling pathway_Homo sapiens_hsa040660.36644550
116VEGF signaling pathway_Homo sapiens_hsa043700.36176406
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35694873
118FoxO signaling pathway_Homo sapiens_hsa040680.33663533
119Folate biosynthesis_Homo sapiens_hsa007900.31483986
120Inositol phosphate metabolism_Homo sapiens_hsa005620.31253974
121Chronic myeloid leukemia_Homo sapiens_hsa052200.29289313
122mRNA surveillance pathway_Homo sapiens_hsa030150.29150517
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27447867
124GnRH signaling pathway_Homo sapiens_hsa049120.26694620
125Small cell lung cancer_Homo sapiens_hsa052220.26650569
126Insulin resistance_Homo sapiens_hsa049310.26492829
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25575791
128Mineral absorption_Homo sapiens_hsa049780.23399772
129Non-small cell lung cancer_Homo sapiens_hsa052230.21493387
130Type II diabetes mellitus_Homo sapiens_hsa049300.19232218
131Galactose metabolism_Homo sapiens_hsa000520.17674732
132MAPK signaling pathway_Homo sapiens_hsa040100.17327410

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