TICRR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.36405149
2regulation of nuclear cell cycle DNA replication (GO:0033262)5.54154654
3mitotic sister chromatid segregation (GO:0000070)5.49817118
4polyketide metabolic process (GO:0030638)5.24544763
5doxorubicin metabolic process (GO:0044598)5.24544763
6daunorubicin metabolic process (GO:0044597)5.24544763
7mitotic sister chromatid cohesion (GO:0007064)5.23071428
8protein localization to chromosome, centromeric region (GO:0071459)5.20065860
9nuclear pore complex assembly (GO:0051292)5.12801813
10regulation of telomere maintenance via telomerase (GO:0032210)4.96750497
11nuclear pore organization (GO:0006999)4.88008252
12DNA replication-dependent nucleosome organization (GO:0034723)4.82630131
13DNA replication-dependent nucleosome assembly (GO:0006335)4.82630131
14sister chromatid segregation (GO:0000819)4.82308306
15histone H4-K12 acetylation (GO:0043983)4.51669778
16mitotic chromosome condensation (GO:0007076)4.44704773
17DNA replication initiation (GO:0006270)4.25638469
18heterochromatin organization (GO:0070828)4.23038290
19negative regulation of telomerase activity (GO:0051974)4.17472009
20DNA topological change (GO:0006265)4.13847977
21mitotic metaphase plate congression (GO:0007080)4.10080138
22DNA unwinding involved in DNA replication (GO:0006268)4.09398450
23pore complex assembly (GO:0046931)3.95662351
24histone H4-K8 acetylation (GO:0043982)3.95318110
25histone H4-K5 acetylation (GO:0043981)3.95318110
26positive regulation of DNA-dependent DNA replication (GO:2000105)3.94864274
27regulation of mammary gland epithelial cell proliferation (GO:0033599)3.93024344
28mitotic nuclear envelope disassembly (GO:0007077)3.82668273
29rRNA modification (GO:0000154)3.78332371
30maintenance of protein location in nucleus (GO:0051457)3.77734594
31DNA duplex unwinding (GO:0032508)3.75272466
32negative regulation of histone methylation (GO:0031061)3.75039896
33regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.74956222
34rRNA transcription (GO:0009303)3.74463262
35negative regulation of telomere maintenance (GO:0032205)3.74388458
36negative regulation of epidermis development (GO:0045683)3.73547397
37DNA geometric change (GO:0032392)3.73406945
38regulation of centriole replication (GO:0046599)3.71638434
39regulation of RNA export from nucleus (GO:0046831)3.70223031
40ribosome biogenesis (GO:0042254)3.69729180
41* DNA replication checkpoint (GO:0000076)3.69278712
42DNA packaging (GO:0006323)3.66716773
43DNA synthesis involved in DNA repair (GO:0000731)3.66666295
44regulation of translation in response to stress (GO:0043555)3.66638190
45attachment of spindle microtubules to kinetochore (GO:0008608)3.66227776
46pre-miRNA processing (GO:0031054)3.66022772
47chromatin assembly (GO:0031497)3.65576009
48positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.63310393
49positive regulation of mitotic sister chromatid separation (GO:1901970)3.63310393
50positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.63310393
51rRNA methylation (GO:0031167)3.61804109
52notochord development (GO:0030903)3.60849869
53regulation of histone H3-K9 methylation (GO:0051570)3.59584799
54regulation of centrosome cycle (GO:0046605)3.56859859
55somite rostral/caudal axis specification (GO:0032525)3.56150571
56regulation of translational fidelity (GO:0006450)3.55584032
57negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.54398089
58metaphase plate congression (GO:0051310)3.54301595
59regulation of sister chromatid cohesion (GO:0007063)3.53709598
60membrane disassembly (GO:0030397)3.52410609
61nuclear envelope disassembly (GO:0051081)3.52410609
62regulation of double-strand break repair via homologous recombination (GO:0010569)3.50986747
63kinetochore organization (GO:0051383)3.48486741
64DNA strand elongation involved in DNA replication (GO:0006271)3.46746830
65negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.46075068
66regulation of double-strand break repair (GO:2000779)3.43422615
67protein localization to chromosome (GO:0034502)3.38477417
68chromatin assembly or disassembly (GO:0006333)3.30345713
69DNA strand elongation (GO:0022616)3.30042303
70regulation of posttranscriptional gene silencing (GO:0060147)3.29967499
71regulation of gene silencing by miRNA (GO:0060964)3.29967499
72regulation of gene silencing by RNA (GO:0060966)3.29967499
73kinetochore assembly (GO:0051382)3.29004468
74nucleotide-excision repair, DNA gap filling (GO:0006297)3.27298120
75regulation of mitotic spindle organization (GO:0060236)3.25268762
76regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.24436649
77regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23879237
78protein complex localization (GO:0031503)3.23761484
79telomere maintenance via semi-conservative replication (GO:0032201)3.23248466
80CENP-A containing nucleosome assembly (GO:0034080)3.22859943
81chromatin remodeling at centromere (GO:0031055)3.22254108
82sister chromatid cohesion (GO:0007062)3.22148557
83aminoglycoside antibiotic metabolic process (GO:0030647)3.21675930
84regulation of mitotic sister chromatid separation (GO:0010965)3.20581196
85regulation of mitotic sister chromatid segregation (GO:0033047)3.20581196
86regulation of sister chromatid segregation (GO:0033045)3.20581196
87DNA replication-independent nucleosome organization (GO:0034724)3.20516925
88DNA replication-independent nucleosome assembly (GO:0006336)3.20516925
89chromosome segregation (GO:0007059)3.19223527
90maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.18915083
91nuclear envelope organization (GO:0006998)3.18526355
92DNA ligation (GO:0006266)3.17533256
93non-recombinational repair (GO:0000726)3.17379299
94double-strand break repair via nonhomologous end joining (GO:0006303)3.17379299
95spindle assembly checkpoint (GO:0071173)3.16773220
96DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.16452176
97establishment of chromosome localization (GO:0051303)3.15021774
98spindle checkpoint (GO:0031577)3.13625074
99regulation of response to osmotic stress (GO:0047484)3.13545241
100negative regulation of mRNA processing (GO:0050686)3.13486809
101establishment of integrated proviral latency (GO:0075713)3.12808770
102DNA conformation change (GO:0071103)3.12333613
103meiotic chromosome segregation (GO:0045132)3.11591265
104folic acid-containing compound biosynthetic process (GO:0009396)3.11178636
105regulation of histone H3-K4 methylation (GO:0051569)3.11130620
106intestinal epithelial cell development (GO:0060576)3.10579814
107negative regulation of epidermal cell differentiation (GO:0045605)3.09835490
108somatic hypermutation of immunoglobulin genes (GO:0016446)3.09785486
109somatic diversification of immune receptors via somatic mutation (GO:0002566)3.09785486
110mitotic recombination (GO:0006312)3.09743868
111mitotic spindle checkpoint (GO:0071174)3.09166841
112regulation of DNA endoreduplication (GO:0032875)3.08659209
113DNA strand renaturation (GO:0000733)3.07031551
114regulation of chromosome segregation (GO:0051983)3.06693689
115negative regulation of chromosome segregation (GO:0051985)3.06529734
116ATP-dependent chromatin remodeling (GO:0043044)3.06446383
117spindle assembly (GO:0051225)3.05402297
118regulation of centrosome duplication (GO:0010824)3.05081606
119regulation of telomere maintenance (GO:0032204)3.04226692
120positive regulation of chromosome segregation (GO:0051984)3.04047648
121histone exchange (GO:0043486)3.02390569
122regulation of spindle organization (GO:0090224)3.01644321
123muscle organ morphogenesis (GO:0048644)3.00244017
124pseudouridine synthesis (GO:0001522)2.99867335
125replication fork processing (GO:0031297)2.99287064
126chromosome condensation (GO:0030261)2.99038156
127negative regulation of sister chromatid segregation (GO:0033046)2.97725480
128negative regulation of mitotic sister chromatid separation (GO:2000816)2.97725480
129negative regulation of mitotic sister chromatid segregation (GO:0033048)2.97725480
130negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.97725480
131histone H4-K16 acetylation (GO:0043984)2.97446796
132DNA damage response, signal transduction resulting in transcription (GO:0042772)2.96808450
133cellular protein complex localization (GO:0034629)2.94981870
134negative regulation of mRNA metabolic process (GO:1903312)2.94592880
135telomere maintenance via recombination (GO:0000722)2.93959189
136telomere maintenance via telomere lengthening (GO:0010833)2.93017205
137mitotic spindle assembly checkpoint (GO:0007094)2.92555083
138ribonucleoprotein complex biogenesis (GO:0022613)2.92258670
139regulation of mitotic metaphase/anaphase transition (GO:0030071)2.91606338
140negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.90678428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.08667067
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.61007991
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.03797861
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.97306848
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.97306848
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.97306848
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.29453051
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.24402610
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.97654732
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.77917612
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.56450422
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.54229800
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.48903191
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40880671
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.33561777
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.32863034
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.25651873
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.23741913
19NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.21924118
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.14063556
21NANOG_18555785_ChIP-Seq_MESCs_Mouse2.10845925
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08809814
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05133597
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.04011355
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03498222
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94568646
27NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.94245112
28SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.89549844
29AR_21909140_ChIP-Seq_LNCAP_Human1.89148641
30TCF3_18692474_ChIP-Seq_MEFs_Mouse1.88194191
31TCF3_18692474_ChIP-Seq_MESCs_Mouse1.87305359
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85268426
33POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.77836730
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73785905
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.71925321
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.69533564
37STAT3_1855785_ChIP-Seq_MESCs_Mouse1.63570104
38NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.62814053
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.62417892
40XRN2_22483619_ChIP-Seq_HELA_Human1.58328586
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55608829
42SOX2_18555785_ChIP-Seq_MESCs_Mouse1.55333960
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.55134809
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.53487309
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50868840
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.50695280
47FOXP3_21729870_ChIP-Seq_TREG_Human1.47929872
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46053235
49MYC_22102868_ChIP-Seq_BL_Human1.45103411
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.43828809
51VDR_23849224_ChIP-Seq_CD4+_Human1.42895022
52CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.41984202
53NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.40548066
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.40350527
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.38585020
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.37489991
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37108850
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32986954
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30411266
60TTF2_22483619_ChIP-Seq_HELA_Human1.30201487
61ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.29843406
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28798513
63KDM5A_27292631_Chip-Seq_BREAST_Human1.28400293
64SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26173184
65POU5F1_16518401_ChIP-PET_MESCs_Mouse1.25327730
66NANOG_21062744_ChIP-ChIP_HESCs_Human1.24123284
67GABP_19822575_ChIP-Seq_HepG2_Human1.23963444
68CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23691479
69IRF1_19129219_ChIP-ChIP_H3396_Human1.21967753
70CIITA_25753668_ChIP-Seq_RAJI_Human1.20699741
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19487195
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18761009
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15898938
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15422793
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15415465
76POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.15257116
77PKCTHETA_26484144_Chip-Seq_BREAST_Human1.15022794
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14878628
79THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13106465
80DCP1A_22483619_ChIP-Seq_HELA_Human1.11693902
81NANOG_18692474_ChIP-Seq_MESCs_Mouse1.10911125
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.10225958
83TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.10101833
84SOX2_18692474_ChIP-Seq_MESCs_Mouse1.09730565
85NANOG_18692474_ChIP-Seq_MEFs_Mouse1.09687395
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08456638
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07058463
88ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05706630
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05384603
90HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04053449
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02152604
92SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01048038
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01011944
94CHD1_26751641_Chip-Seq_LNCaP_Human1.00965583
95OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00528717
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00393526
97ELK1_19687146_ChIP-ChIP_HELA_Human0.99311413
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98792367
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97373428
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93413361
101NANOG_16153702_ChIP-ChIP_HESCs_Human0.93192699
102HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91361986
103ZNF263_19887448_ChIP-Seq_K562_Human0.91150579
104FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.89952134
105MYC_18940864_ChIP-ChIP_HL60_Human0.89614828
106PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88680378
107E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.88300448
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88157616
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86842635
110PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.85848782
111CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84829345
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84797889
113TFEB_21752829_ChIP-Seq_HELA_Human0.84588431
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84504877
115ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83878236
116SOX2_16153702_ChIP-ChIP_HESCs_Human0.83511655
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83082955
118NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82881745
119SOX17_20123909_ChIP-Seq_XEN_Mouse0.82842622
120TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.81749307
121VDR_21846776_ChIP-Seq_THP-1_Human0.74283972
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.71685083
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.71419779
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.70238950
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.70086764
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.69338860
127TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.68798242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.67411624
2MP0004957_abnormal_blastocyst_morpholog4.11458610
3MP0003693_abnormal_embryo_hatching3.73063100
4MP0003111_abnormal_nucleus_morphology3.72766737
5MP0010094_abnormal_chromosome_stability3.71305516
6MP0003077_abnormal_cell_cycle3.36494204
7MP0006292_abnormal_olfactory_placode3.24987057
8MP0004264_abnormal_extraembryonic_tissu2.96765624
9MP0003890_abnormal_embryonic-extraembry2.86712240
10MP0008058_abnormal_DNA_repair2.44318491
11MP0003121_genomic_imprinting2.34720032
12MP0010352_gastrointestinal_tract_polyps2.32480188
13MP0000350_abnormal_cell_proliferation2.26809519
14MP0008932_abnormal_embryonic_tissue2.21191609
15MP0005380_embryogenesis_phenotype2.19979523
16MP0001672_abnormal_embryogenesis/_devel2.19979523
17MP0008007_abnormal_cellular_replicative2.06185057
18MP0003123_paternal_imprinting2.03810842
19MP0005075_abnormal_melanosome_morpholog2.03113755
20MP0002653_abnormal_ependyma_morphology1.99178533
21MP0003984_embryonic_growth_retardation1.94640145
22MP0002088_abnormal_embryonic_growth/wei1.93046277
23MP0001730_embryonic_growth_arrest1.92670027
24MP0002396_abnormal_hematopoietic_system1.91897121
25MP0005394_taste/olfaction_phenotype1.87525214
26MP0005499_abnormal_olfactory_system1.87525214
27MP0002085_abnormal_embryonic_tissue1.80985909
28MP0003011_delayed_dark_adaptation1.80333357
29MP0001293_anophthalmia1.74301118
30MP0001346_abnormal_lacrimal_gland1.70387111
31MP0010030_abnormal_orbit_morphology1.67779630
32MP0002084_abnormal_developmental_patter1.65430434
33MP0002086_abnormal_extraembryonic_tissu1.63659986
34MP0004233_abnormal_muscle_weight1.60141608
35MP0002254_reproductive_system_inflammat1.59525148
36MP0001697_abnormal_embryo_size1.59356696
37MP0009697_abnormal_copulation1.58546354
38MP0000537_abnormal_urethra_morphology1.58428328
39MP0009672_abnormal_birth_weight1.57982804
40MP0003786_premature_aging1.57756358
41MP0003718_maternal_effect1.52620866
42MP0003315_abnormal_perineum_morphology1.48177608
43MP0000490_abnormal_crypts_of1.45740988
44MP0004197_abnormal_fetal_growth/weight/1.43186388
45MP0002697_abnormal_eye_size1.42401908
46MP0003122_maternal_imprinting1.40524897
47MP0003938_abnormal_ear_development1.39388680
48MP0000566_synostosis1.37039200
49MP0002080_prenatal_lethality1.36576408
50MP0000313_abnormal_cell_death1.36501244
51MP0003705_abnormal_hypodermis_morpholog1.36242506
52MP0008877_abnormal_DNA_methylation1.35537716
53MP0002009_preneoplasia1.29724719
54MP0010307_abnormal_tumor_latency1.26975123
55MP0005257_abnormal_intraocular_pressure1.26099747
56MP0002092_abnormal_eye_morphology1.23107183
57MP0003787_abnormal_imprinting1.20703237
58MP0003119_abnormal_digestive_system1.19956118
59MP0004185_abnormal_adipocyte_glucose1.19205272
60MP0000678_abnormal_parathyroid_gland1.17177305
61MP0002277_abnormal_respiratory_mucosa1.16944087
62MP0004133_heterotaxia1.16538223
63MP0002332_abnormal_exercise_endurance1.15895175
64MP0006035_abnormal_mitochondrial_morpho1.15219111
65MP0003937_abnormal_limbs/digits/tail_de1.11052340
66MP0002019_abnormal_tumor_incidence1.08878466
67MP0001849_ear_inflammation1.07774303
68MP0001661_extended_life_span1.07023380
69MP0000432_abnormal_head_morphology1.05210061
70MP0002210_abnormal_sex_determination1.03441725
71MP0001145_abnormal_male_reproductive1.02338199
72MP0002932_abnormal_joint_morphology1.01778099
73MP0008789_abnormal_olfactory_epithelium1.00464324
74MP0000428_abnormal_craniofacial_morphol1.00396629
75MP0003755_abnormal_palate_morphology0.99420248
76MP0002127_abnormal_cardiovascular_syste0.96949414
77MP0003699_abnormal_female_reproductive0.96709181
78MP0003935_abnormal_craniofacial_develop0.93901336
79MP0000049_abnormal_middle_ear0.93539873
80MP0009703_decreased_birth_body0.93389724
81MP0005076_abnormal_cell_differentiation0.92751560
82MP0002160_abnormal_reproductive_system0.91676281
83MP0003941_abnormal_skin_development0.90789417
84MP0001286_abnormal_eye_development0.90377085
85MP0002114_abnormal_axial_skeleton0.89713317
86MP0005623_abnormal_meninges_morphology0.87408851
87MP0000762_abnormal_tongue_morphology0.87395736
88MP0002877_abnormal_melanocyte_morpholog0.87223995
89MP0002938_white_spotting0.87181907
90MP0003942_abnormal_urinary_system0.86536164
91MP0001929_abnormal_gametogenesis0.85462425
92MP0002233_abnormal_nose_morphology0.84519602
93MP0010234_abnormal_vibrissa_follicle0.84394597
94MP0005266_abnormal_metabolism0.83274453
95MP0002234_abnormal_pharynx_morphology0.82658800
96MP0002111_abnormal_tail_morphology0.81955282
97MP0005384_cellular_phenotype0.81618690
98MP0002249_abnormal_larynx_morphology0.78771879
99MP0005187_abnormal_penis_morphology0.78578374
100MP0004858_abnormal_nervous_system0.78027717
101MP0002161_abnormal_fertility/fecundity0.77499627
102MP0000653_abnormal_sex_gland0.77361930
103MP0003943_abnormal_hepatobiliary_system0.77351488
104MP0009053_abnormal_anal_canal0.77209961
105MP0003283_abnormal_digestive_organ0.77094629
106MP0000383_abnormal_hair_follicle0.76278946
107MP0003136_yellow_coat_color0.75874690
108MP0003115_abnormal_respiratory_system0.75687137
109MP0001119_abnormal_female_reproductive0.73700265
110MP0005501_abnormal_skin_physiology0.73080461
111MP0003385_abnormal_body_wall0.72121151
112MP0002925_abnormal_cardiovascular_devel0.71142695
113MP0008770_decreased_survivor_rate0.70987389
114MP0005621_abnormal_cell_physiology0.70814436
115MP0008995_early_reproductive_senescence0.70120863
116MP0005023_abnormal_wound_healing0.69959166
117MP0002132_abnormal_respiratory_system0.68519750
118MP0002116_abnormal_craniofacial_bone0.68216499
119MP0002751_abnormal_autonomic_nervous0.68109829
120MP0005391_vision/eye_phenotype0.67451638
121MP0003861_abnormal_nervous_system0.67292281
122MP0005395_other_phenotype0.67005711
123MP0004808_abnormal_hematopoietic_stem0.66714584
124MP0000703_abnormal_thymus_morphology0.66612210
125MP0000358_abnormal_cell_content/0.66460917
126MP0003698_abnormal_male_reproductive0.65283037
127MP0003567_abnormal_fetal_cardiomyocyte0.63115327
128MP0004381_abnormal_hair_follicle0.62133941
129MP0002970_abnormal_white_adipose0.61415943

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.36464862
2Chromsome breakage (HP:0040012)5.13038596
3Bilateral microphthalmos (HP:0007633)4.87087867
4Ependymoma (HP:0002888)4.54061559
5Hypochromic microcytic anemia (HP:0004840)4.40260117
6Rhabdomyosarcoma (HP:0002859)3.87241806
7Rib fusion (HP:0000902)3.86119156
8Meckel diverticulum (HP:0002245)3.79993945
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.76397796
10Impulsivity (HP:0100710)3.69840512
11Abnormality of the ileum (HP:0001549)3.61552160
12Neoplasm of striated muscle (HP:0009728)3.57236015
13Nephroblastoma (Wilms tumor) (HP:0002667)3.50077543
14Multiple enchondromatosis (HP:0005701)3.47687372
15Abnormality of chromosome stability (HP:0003220)3.25733644
16Embryonal renal neoplasm (HP:0011794)3.23361456
17Abnormality of the astrocytes (HP:0100707)3.18536152
18Astrocytoma (HP:0009592)3.18536152
19Abnormality of the preputium (HP:0100587)3.14381421
20Small intestinal stenosis (HP:0012848)3.09494008
21Duodenal stenosis (HP:0100867)3.09494008
22Medulloblastoma (HP:0002885)3.07443159
23Hepatoblastoma (HP:0002884)3.06611536
24Supernumerary spleens (HP:0009799)3.03440115
25Abnormal lung lobation (HP:0002101)2.96548148
26Abnormality of the lower motor neuron (HP:0002366)2.92821356
27Birth length less than 3rd percentile (HP:0003561)2.88681441
28Abnormality of the labia minora (HP:0012880)2.86527319
29Aplasia/hypoplasia of the humerus (HP:0006507)2.86230201
30Breast hypoplasia (HP:0003187)2.85269121
31Rectovaginal fistula (HP:0000143)2.83862604
32Rectal fistula (HP:0100590)2.83862604
33Abnormality of cochlea (HP:0000375)2.82998692
34Glioma (HP:0009733)2.80458792
35Shawl scrotum (HP:0000049)2.73628391
36Intestinal fistula (HP:0100819)2.66776075
37Short humerus (HP:0005792)2.65217676
38Patellar aplasia (HP:0006443)2.63954674
39Reticulocytopenia (HP:0001896)2.62508115
40Myelodysplasia (HP:0002863)2.55065367
41Septate vagina (HP:0001153)2.55012442
42Selective tooth agenesis (HP:0001592)2.53125984
43Fused cervical vertebrae (HP:0002949)2.52477814
44Absent radius (HP:0003974)2.52073744
45Abnormality of chromosome segregation (HP:0002916)2.51944020
46Abnormality of the duodenum (HP:0002246)2.51111428
47Trismus (HP:0000211)2.49982757
48Sloping forehead (HP:0000340)2.49867135
49Short thumb (HP:0009778)2.47692425
50High anterior hairline (HP:0009890)2.46924439
51Aplasia/Hypoplasia of the patella (HP:0006498)2.43713623
52Abnormality of the salivary glands (HP:0010286)2.43593271
53Neoplasm of the oral cavity (HP:0100649)2.35933711
54Aplasia/Hypoplasia of the sternum (HP:0006714)2.34810336
55Absent forearm bone (HP:0003953)2.34036210
56Aplasia involving forearm bones (HP:0009822)2.34036210
57Premature ovarian failure (HP:0008209)2.32265980
58Carpal bone hypoplasia (HP:0001498)2.31696551
59Proximal placement of thumb (HP:0009623)2.28308624
60Aplasia/Hypoplasia of the fovea (HP:0008060)2.27892249
61Hypoplasia of the fovea (HP:0007750)2.27892249
62Vaginal fistula (HP:0004320)2.26847657
63Bone marrow hypocellularity (HP:0005528)2.25785936
64Urethral obstruction (HP:0000796)2.25710880
65Atresia of the external auditory canal (HP:0000413)2.24045233
66Deviation of the thumb (HP:0009603)2.23564190
67Volvulus (HP:0002580)2.23191023
68Microvesicular hepatic steatosis (HP:0001414)2.22601514
69Choanal atresia (HP:0000453)2.22065667
70Triphalangeal thumb (HP:0001199)2.20780702
71Cortical dysplasia (HP:0002539)2.19032562
72Bifid tongue (HP:0010297)2.18790780
73Abnormality of DNA repair (HP:0003254)2.18033200
74Preauricular skin tag (HP:0000384)2.16958867
75Duplicated collecting system (HP:0000081)2.16496484
76Horseshoe kidney (HP:0000085)2.14636139
77Abnormal number of incisors (HP:0011064)2.13637502
78Testicular atrophy (HP:0000029)2.12703234
79Hypochromic anemia (HP:0001931)2.12670486
80Deep philtrum (HP:0002002)2.10086438
81Ectopic kidney (HP:0000086)2.09709013
82Overlapping toe (HP:0001845)2.08995149
83Facial hemangioma (HP:0000329)2.07002263
84Morphological abnormality of the inner ear (HP:0011390)2.06693270
85Clubbing of toes (HP:0100760)2.06493432
86Tracheoesophageal fistula (HP:0002575)2.05242501
87Abnormality of the carotid arteries (HP:0005344)2.03818916
88Prominent nose (HP:0000448)2.02543297
89Microretrognathia (HP:0000308)2.01546675
90Atrophy/Degeneration involving motor neurons (HP:0007373)1.99972936
91Amyotrophic lateral sclerosis (HP:0007354)1.98719516
92Partial duplication of thumb phalanx (HP:0009944)1.97939714
93Obsessive-compulsive behavior (HP:0000722)1.97307014
94Skin tags (HP:0010609)1.96349041
95Cafe-au-lait spot (HP:0000957)1.95814259
96Arteriovenous malformation (HP:0100026)1.95084015
97Increased nuchal translucency (HP:0010880)1.94683245
98Broad distal phalanx of finger (HP:0009836)1.93536131
99Sandal gap (HP:0001852)1.93307279
100Anal stenosis (HP:0002025)1.93208383
101Squamous cell carcinoma (HP:0002860)1.92337687
102Spinal muscular atrophy (HP:0007269)1.92300642
103Long eyelashes (HP:0000527)1.92103610
104Abnormality of the phalanges of the hallux (HP:0010057)1.91786314
105Heterotopia (HP:0002282)1.91474639
106Supernumerary ribs (HP:0005815)1.90051465
107Tongue fasciculations (HP:0001308)1.89022499
108Pendular nystagmus (HP:0012043)1.88631448
109Absent thumb (HP:0009777)1.88348356
110Abnormality of abdominal situs (HP:0011620)1.87292282
111Abdominal situs inversus (HP:0003363)1.87292282
112Degeneration of anterior horn cells (HP:0002398)1.86390182
113Abnormality of the anterior horn cell (HP:0006802)1.86390182
114Supernumerary bones of the axial skeleton (HP:0009144)1.86145844
115Poikiloderma (HP:0001029)1.85454328
116Abnormality of the fingertips (HP:0001211)1.85363516
117Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84449380
118Embryonal neoplasm (HP:0002898)1.83732697
119Missing ribs (HP:0000921)1.82863226
120Secondary amenorrhea (HP:0000869)1.81830820
121Large earlobe (HP:0009748)1.80660775
122Malignant neoplasm of the central nervous system (HP:0100836)1.80623892
123Aplastic anemia (HP:0001915)1.79831606
124Facial cleft (HP:0002006)1.78733525
125Hyperacusis (HP:0010780)1.77597312
126Progressive external ophthalmoplegia (HP:0000590)1.76914945
127Duplication of thumb phalanx (HP:0009942)1.76483980
128Cleft eyelid (HP:0000625)1.76080616
129Abnormality of the renal collecting system (HP:0004742)1.75803417
130Deep palmar crease (HP:0006191)1.75785039
131Capillary hemangiomas (HP:0005306)1.75321362
132Progressive muscle weakness (HP:0003323)1.74804578
133Dysmetric saccades (HP:0000641)1.74731032
134Partial duplication of the phalanx of hand (HP:0009999)1.74685770
135Preauricular pit (HP:0004467)1.74098366
136Abnormality of the calcaneus (HP:0008364)1.68463996
137Abnormality of the distal phalanx of the thumb (HP:0009617)1.67109479
138Homocystinuria (HP:0002156)1.65340600
139Abnormality of homocysteine metabolism (HP:0010919)1.65340600
14011 pairs of ribs (HP:0000878)1.63233400
141Hypergonadotropic hypogonadism (HP:0000815)1.62872607
142Aplasia/Hypoplasia of the earlobes (HP:0009906)1.62271044

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.64006709
2TTK3.93736037
3CDC73.44643343
4WEE13.07874764
5BUB12.89717845
6GRK52.73761006
7SMG12.55091122
8GRK62.48514268
9NEK22.35485134
10CHEK22.28129764
11PLK12.25660974
12STK102.25255398
13CDK72.23067868
14EPHA22.08988242
15ICK2.06023321
16ERN12.00930896
17PBK1.98630539
18PLK41.97745131
19CAMK1D1.81669799
20CAMK1G1.81129757
21CSF1R1.72716558
22SRPK11.67716586
23GRK11.63282028
24ADRBK21.59165780
25TRIB31.58235558
26TYRO31.54922003
27AKT31.52621942
28EIF2AK11.50500199
29NEK11.46075692
30AURKB1.39580882
31* CHEK11.38399537
32MATK1.35291122
33MAPK71.32078009
34ATR1.29230473
35RPS6KB21.29154372
36TAF11.28866924
37VRK21.22933002
38CDK41.22896201
39PAK41.18875736
40ACVR1B1.18268789
41BRSK21.17394867
42MAP3K91.14671005
43BRD41.14327561
44DYRK31.14218754
45ERBB41.13121103
46LATS21.11725169
47AURKA1.08139814
48MOS1.07212481
49TGFBR21.06560695
50ATM1.02699855
51CDK20.99150718
52PLK30.98919073
53MAP3K130.96208215
54ZAK0.92968415
55MAP3K100.92792005
56TSSK60.91976734
57GRK70.91710199
58STK40.91578335
59EIF2AK30.90368087
60ALK0.88155049
61TESK20.88132309
62SCYL20.84042586
63LATS10.83764078
64MAP3K80.83232912
65EIF2AK20.82988338
66RAF10.81093497
67STK38L0.80795141
68STK30.80080901
69CLK10.80030192
70MET0.78586600
71MTOR0.74906946
72MKNK20.74223109
73VRK10.72937990
74PRKCI0.72911041
75BRSK10.72752395
76CDK10.72541442
77WNK10.72494088
78MKNK10.69832564
79MAPK110.67702553
80MELK0.66938462
81AKT20.66691301
82CAMK40.65412170
83KSR20.64200579
84CDK90.63802847
85TLK10.60528517
86PIM10.60490285
87PKN20.59208160
88NME10.59098026
89PRKG20.58426067
90CDK80.56788787
91MST1R0.54748449
92PAK10.53311183
93CSNK1E0.49435331
94HIPK20.48160516
95FGFR10.43103662
96MAPKAPK30.42744806
97MARK20.42179996
98MAPK140.40301409
99CDK60.39709724
100ADRBK10.38998528
101CDK30.38265062
102EEF2K0.38010467
103PASK0.37306044
104TRIM280.37267715
105IRAK30.37026410
106DYRK20.34311795
107CDK11A0.34123131
108GSK3B0.34030063
109MAP3K60.33229519
110PDK20.33205200
111CSNK2A10.33116576
112CDK150.33090372
113RPS6KA40.32472075
114MAPK100.32206990
115NEK60.31072694
116CDK180.30190881
117MAPK10.29975571
118FGFR30.29634006
119CSNK2A20.29496700
120PAK20.28536563
121BRAF0.28458553
122MAPKAPK50.27799865
123CSK0.26349070
124RPS6KA10.26143612
125PRKAA10.25827157
126AKT10.25257320
127CSNK1D0.24927918
128PNCK0.24705618
129CHUK0.24525038
130NTRK10.24078592
131CCNB10.20028442
132NME20.18744661
133PRKDC0.18203711

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.44365534
2DNA replication_Homo sapiens_hsa030304.25445657
3Mismatch repair_Homo sapiens_hsa034303.75914606
4Vitamin B6 metabolism_Homo sapiens_hsa007503.60187668
5RNA transport_Homo sapiens_hsa030133.19111422
6Fanconi anemia pathway_Homo sapiens_hsa034603.06869338
7Cell cycle_Homo sapiens_hsa041103.06699538
8Homologous recombination_Homo sapiens_hsa034403.05698613
9Spliceosome_Homo sapiens_hsa030402.71056532
10Base excision repair_Homo sapiens_hsa034102.63459103
11RNA polymerase_Homo sapiens_hsa030202.56499271
12One carbon pool by folate_Homo sapiens_hsa006702.35650543
13Nucleotide excision repair_Homo sapiens_hsa034202.27176611
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.21150145
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.10525460
16mRNA surveillance pathway_Homo sapiens_hsa030152.07110126
17RNA degradation_Homo sapiens_hsa030182.02219884
18Basal transcription factors_Homo sapiens_hsa030221.99066034
19Ribosome_Homo sapiens_hsa030101.97270466
20p53 signaling pathway_Homo sapiens_hsa041151.92561202
21Non-homologous end-joining_Homo sapiens_hsa034501.84807086
22Pyrimidine metabolism_Homo sapiens_hsa002401.82090444
23Fructose and mannose metabolism_Homo sapiens_hsa000511.63884697
24Proteasome_Homo sapiens_hsa030501.46803905
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.33938009
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19912999
27Arachidonic acid metabolism_Homo sapiens_hsa005901.19636857
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11326159
29MicroRNAs in cancer_Homo sapiens_hsa052061.06393270
30Galactose metabolism_Homo sapiens_hsa000521.06187285
31Thyroid cancer_Homo sapiens_hsa052161.04975441
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04504584
33Chronic myeloid leukemia_Homo sapiens_hsa052201.02402970
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01692081
35Herpes simplex infection_Homo sapiens_hsa051680.99716820
36Linoleic acid metabolism_Homo sapiens_hsa005910.99307193
37Basal cell carcinoma_Homo sapiens_hsa052170.94128204
38Oocyte meiosis_Homo sapiens_hsa041140.92482995
39mTOR signaling pathway_Homo sapiens_hsa041500.92337167
40Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91568310
41Purine metabolism_Homo sapiens_hsa002300.87002530
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86514207
43Viral carcinogenesis_Homo sapiens_hsa052030.83315820
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81826538
45Epstein-Barr virus infection_Homo sapiens_hsa051690.81782619
46Pyruvate metabolism_Homo sapiens_hsa006200.81771967
47Alcoholism_Homo sapiens_hsa050340.81590412
48Carbon metabolism_Homo sapiens_hsa012000.78563654
49Folate biosynthesis_Homo sapiens_hsa007900.77858318
50Hippo signaling pathway_Homo sapiens_hsa043900.76397963
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75447020
52HTLV-I infection_Homo sapiens_hsa051660.74716838
53Pentose phosphate pathway_Homo sapiens_hsa000300.73884129
54Systemic lupus erythematosus_Homo sapiens_hsa053220.72175157
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71292901
56Hedgehog signaling pathway_Homo sapiens_hsa043400.71177767
57Notch signaling pathway_Homo sapiens_hsa043300.66815588
58Steroid biosynthesis_Homo sapiens_hsa001000.66645919
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62490808
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.58315832
61Pathways in cancer_Homo sapiens_hsa052000.57146702
62Small cell lung cancer_Homo sapiens_hsa052220.55955704
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55525857
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55413910
65Endometrial cancer_Homo sapiens_hsa052130.54186878
66Biosynthesis of amino acids_Homo sapiens_hsa012300.51374243
67N-Glycan biosynthesis_Homo sapiens_hsa005100.51289213
68Melanoma_Homo sapiens_hsa052180.50693219
69Colorectal cancer_Homo sapiens_hsa052100.50106220
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49872868
71TGF-beta signaling pathway_Homo sapiens_hsa043500.49785046
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48897681
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47885953
74Glioma_Homo sapiens_hsa052140.46905360
75Antigen processing and presentation_Homo sapiens_hsa046120.46115056
76Apoptosis_Homo sapiens_hsa042100.44381864
77Adherens junction_Homo sapiens_hsa045200.42159394
78ErbB signaling pathway_Homo sapiens_hsa040120.40979431
79Bladder cancer_Homo sapiens_hsa052190.40514874
80Wnt signaling pathway_Homo sapiens_hsa043100.40210281
81Selenocompound metabolism_Homo sapiens_hsa004500.39749671
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39431986
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38436621
84Regulation of autophagy_Homo sapiens_hsa041400.38382594
85Acute myeloid leukemia_Homo sapiens_hsa052210.36993921
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.36951708
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36323932
88Primary immunodeficiency_Homo sapiens_hsa053400.35611701
89Lysine degradation_Homo sapiens_hsa003100.35048606
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.34966726
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.34572122
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34480233
93Insulin signaling pathway_Homo sapiens_hsa049100.34289772
94Inositol phosphate metabolism_Homo sapiens_hsa005620.32172314
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31686674
96Non-small cell lung cancer_Homo sapiens_hsa052230.30494046
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30309298
98FoxO signaling pathway_Homo sapiens_hsa040680.28505588
99Other glycan degradation_Homo sapiens_hsa005110.28362643
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.28012206
101Pancreatic cancer_Homo sapiens_hsa052120.27933805
102Sulfur relay system_Homo sapiens_hsa041220.27566304
103Ether lipid metabolism_Homo sapiens_hsa005650.26957519
104Ovarian steroidogenesis_Homo sapiens_hsa049130.26780838
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25793502
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24574206
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24172626
108Arginine biosynthesis_Homo sapiens_hsa002200.23956299
109Renal cell carcinoma_Homo sapiens_hsa052110.23617201
110Fatty acid biosynthesis_Homo sapiens_hsa000610.23427940
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22515028
112Glutathione metabolism_Homo sapiens_hsa004800.22453591
113Prostate cancer_Homo sapiens_hsa052150.22013375
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.21316360
115Choline metabolism in cancer_Homo sapiens_hsa052310.20436244
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19680443
117Tight junction_Homo sapiens_hsa045300.19351179
118Vitamin digestion and absorption_Homo sapiens_hsa049770.18206427
119Influenza A_Homo sapiens_hsa051640.17731996
120Hepatitis B_Homo sapiens_hsa051610.17704001
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.16279646
122Proteoglycans in cancer_Homo sapiens_hsa052050.15751829
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14769376
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14215195
125AMPK signaling pathway_Homo sapiens_hsa041520.13990293
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.13405452
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.13015533

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