TIE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)7.60014900
2vascular endothelial growth factor signaling pathway (GO:0038084)7.00277470
3blood vessel maturation (GO:0001955)6.41105865
4endothelium development (GO:0003158)6.18637323
5wound healing, spreading of epidermal cells (GO:0035313)6.08776990
6surfactant homeostasis (GO:0043129)6.06274258
7lymphangiogenesis (GO:0001946)5.99772620
8cellular response to vascular endothelial growth factor stimulus (GO:0035924)5.98542839
9endothelial tube morphogenesis (GO:0061154)5.55895024
10morphogenesis of an endothelium (GO:0003159)5.55895024
11positive regulation of vasculogenesis (GO:2001214)5.54173707
12retina vasculature morphogenesis in camera-type eye (GO:0061299)5.53822839
13regulation of endothelial cell differentiation (GO:0045601)5.19428424
14venous blood vessel morphogenesis (GO:0048845)5.03980017
15Notch signaling involved in heart development (GO:0061314)4.88189311
16ovulation from ovarian follicle (GO:0001542)4.85112844
17bundle of His cell to Purkinje myocyte communication (GO:0086069)4.78733812
18chemical homeostasis within a tissue (GO:0048875)4.73824721
19regulation of vasculogenesis (GO:2001212)4.73690692
20artery development (GO:0060840)4.72542271
21heart trabecula formation (GO:0060347)4.69833073
22glomerular filtration (GO:0003094)4.54324449
23negative regulation of adherens junction organization (GO:1903392)4.52045927
24negative regulation of focal adhesion assembly (GO:0051895)4.52045927
25negative regulation of cell junction assembly (GO:1901889)4.52045927
26negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.50453829
27endothelial cell morphogenesis (GO:0001886)4.45543853
28renal filtration (GO:0097205)4.40955523
29endothelial cell differentiation (GO:0045446)4.40654682
30patterning of blood vessels (GO:0001569)4.40497679
31vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.34137098
32cardiac myofibril assembly (GO:0055003)4.33892472
33negative regulation of nitric-oxide synthase activity (GO:0051001)4.18185147
34basement membrane organization (GO:0071711)4.15108501
35cell migration involved in sprouting angiogenesis (GO:0002042)4.11140401
36blood vessel endothelial cell migration (GO:0043534)4.09563557
37positive regulation of urine volume (GO:0035810)4.04521193
38sarcomere organization (GO:0045214)3.90946080
39negative regulation of epithelial cell migration (GO:0010633)3.90335800
40neuron remodeling (GO:0016322)3.88759286
41wound healing, spreading of cells (GO:0044319)3.84699296
42regulation of establishment or maintenance of cell polarity (GO:0032878)3.79655354
43positive regulation of endothelial cell differentiation (GO:0045603)3.70953417
44hyaluronan catabolic process (GO:0030214)3.70883579
45myofibril assembly (GO:0030239)3.68039770
46* angiogenesis (GO:0001525)3.67140209
47plasma membrane repair (GO:0001778)3.65616130
48cell migration involved in heart development (GO:0060973)3.65271302
49nephron epithelium development (GO:0072009)3.63375236
50sprouting angiogenesis (GO:0002040)3.62664108
51regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.61499737
52negative regulation of blood vessel endothelial cell migration (GO:0043537)3.57718152
53fatty acid transmembrane transport (GO:1902001)3.55864669
54embryonic heart tube development (GO:0035050)3.51580210
55* vasculogenesis (GO:0001570)3.48174650
56positive regulation of odontogenesis (GO:0042482)3.44684657
57ganglion development (GO:0061548)3.43542934
58negative regulation of DNA biosynthetic process (GO:2000279)3.41015431
59anatomical structure maturation (GO:0071695)3.35365077
60semaphorin-plexin signaling pathway (GO:0071526)3.32677234
61carnitine shuttle (GO:0006853)3.31837644
62negative regulation of endothelial cell migration (GO:0010596)3.31238409
63peptidyl-tyrosine autophosphorylation (GO:0038083)3.26005220
64coronary vasculature morphogenesis (GO:0060977)3.24301192
65positive regulation of protein kinase C signaling (GO:0090037)3.22595637
66endothelial cell migration (GO:0043542)3.20140569
67negative regulation of endothelial cell apoptotic process (GO:2000352)3.18920356
68regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.18683689
69regulation of focal adhesion assembly (GO:0051893)3.18455809
70regulation of cell-substrate junction assembly (GO:0090109)3.18455809
71regulation of actin filament-based movement (GO:1903115)3.17565781
72mRNA transcription from RNA polymerase II promoter (GO:0042789)3.17555758
73ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.14821210
74regulation of adherens junction organization (GO:1903391)3.14312621
75regulation of epithelial cell migration (GO:0010632)3.09978370
76endothelial cell chemotaxis (GO:0035767)3.09331306
77* negative regulation of angiogenesis (GO:0016525)3.08426550
78gap junction assembly (GO:0016264)3.07182638
79regulation of cardioblast differentiation (GO:0051890)3.06925231
80positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.06122238
81positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)3.04083199
82arginine catabolic process (GO:0006527)3.03616665
83negative regulation of platelet activation (GO:0010544)3.00131307
84regulation of endothelial cell proliferation (GO:0001936)2.99944946
85positive regulation of epithelial cell migration (GO:0010634)2.99852899
86regulation of urine volume (GO:0035809)2.99284558
87cardiac muscle tissue morphogenesis (GO:0055008)2.95763396
88* negative regulation of blood vessel morphogenesis (GO:2000181)2.95687055
89cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.95105147
90positive regulation of adherens junction organization (GO:1903393)2.94262198
91positive regulation of receptor recycling (GO:0001921)2.94227757
92protein kinase C signaling (GO:0070528)2.94001990
93regulation of vascular permeability (GO:0043114)2.93027836
94muscle filament sliding (GO:0030049)2.92156919
95actin-myosin filament sliding (GO:0033275)2.92156919
96Notch receptor processing (GO:0007220)2.91270660
97definitive hemopoiesis (GO:0060216)2.89554808
98regulation of endothelial cell apoptotic process (GO:2000351)2.88483690
99blood vessel remodeling (GO:0001974)2.87943967
100heart valve formation (GO:0003188)2.87598846
101angiogenesis involved in wound healing (GO:0060055)2.87231435
102negative regulation of Rho protein signal transduction (GO:0035024)2.87153942
103trabecula formation (GO:0060343)2.86909485
104regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.86779421
105endocrine process (GO:0050886)2.86779421
106regulation of systemic arterial blood pressure by hormone (GO:0001990)2.86779421
107actomyosin structure organization (GO:0031032)2.83708084
108transcytosis (GO:0045056)2.83461914
109regulation of sarcomere organization (GO:0060297)2.83248577
110regulation of blood vessel endothelial cell migration (GO:0043535)2.82955942
111regulation of establishment of cell polarity (GO:2000114)2.82306475
112regulation of glomerular filtration (GO:0003093)2.81830416
113negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.81131267
114ovulation (GO:0030728)2.80183078
115labyrinthine layer development (GO:0060711)2.78606447
116negative regulation of vascular permeability (GO:0043116)2.77484349
117regulation of relaxation of muscle (GO:1901077)2.76747410
118endothelial cell proliferation (GO:0001935)2.76134761
119trabecula morphogenesis (GO:0061383)2.75335778
120cAMP biosynthetic process (GO:0006171)2.75205391
121regulation of endothelial cell migration (GO:0010594)2.74498408
122establishment of endothelial barrier (GO:0061028)2.73527954
123regulation of p38MAPK cascade (GO:1900744)2.72958713
124axon extension involved in axon guidance (GO:0048846)2.72490752
125neuron projection extension involved in neuron projection guidance (GO:1902284)2.72490752
126negative regulation of endothelial cell proliferation (GO:0001937)2.71681404
127negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.71201155
128negative regulation of protein autophosphorylation (GO:0031953)2.70568238
129regulation of the force of heart contraction (GO:0002026)2.68899899
130cardiac muscle contraction (GO:0060048)2.68789587
131tricarboxylic acid cycle (GO:0006099)2.68722765
132ventricular trabecula myocardium morphogenesis (GO:0003222)2.68524916
133cardiac muscle cell development (GO:0055013)2.68485175
134positive regulation of focal adhesion assembly (GO:0051894)2.68262049
135positive regulation of cell junction assembly (GO:1901890)2.68262049
136substrate-dependent cell migration (GO:0006929)2.66527906
137muscle tissue morphogenesis (GO:0060415)2.66227446
138phagocytosis, recognition (GO:0006910)2.64875550
139regulation of sequestering of triglyceride (GO:0010889)2.62233839
140ventricular cardiac muscle cell action potential (GO:0086005)2.61754735
141dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.61136313
142cardiac cell development (GO:0055006)2.60786496
143heart trabecula morphogenesis (GO:0061384)2.60686882
144positive regulation of endothelial cell migration (GO:0010595)2.60013445
145positive regulation of endothelial cell proliferation (GO:0001938)2.58108076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.24432986
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.49331480
3GATA2_21666600_ChIP-Seq_HMVEC_Human4.01597445
4CLOCK_20551151_ChIP-Seq_293T_Human3.49990715
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.24551081
6GATA1_22025678_ChIP-Seq_K562_Human3.01957308
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.85500650
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.78970881
9EP300_21415370_ChIP-Seq_HL-1_Mouse2.67195067
10ZNF263_19887448_ChIP-Seq_K562_Human2.59862525
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.54425349
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43107380
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.42448663
14TBX20_22328084_ChIP-Seq_HEART_Mouse2.40826320
15TBX20_22080862_ChIP-Seq_HEART_Mouse2.40826320
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31770374
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26216826
18RXR_22158963_ChIP-Seq_LIVER_Mouse2.22321823
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.20069621
20PPARA_22158963_ChIP-Seq_LIVER_Mouse2.03656934
21TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.03618426
22ESR1_21235772_ChIP-Seq_MCF-7_Human2.00886783
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.97160802
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96938078
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.96902889
26EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.95245284
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95065415
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.94637965
29SCL_19346495_ChIP-Seq_HPC-7_Human1.94571611
30GATA1_19941826_ChIP-Seq_K562_Human1.94108267
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.91383949
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.91383949
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.82729240
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.82134864
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73054456
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.67173080
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.66283617
38* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.63028950
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.62335688
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53961542
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.50682656
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47521141
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.45665548
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.45519084
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44971883
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42086869
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37785748
48FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.35497067
49SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33841114
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33593138
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.32124530
52SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31777246
53BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31172344
54* LXR_22292898_ChIP-Seq_THP-1_Human1.29075974
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28021972
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26322631
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23611802
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.23444141
59GATA2_19941826_ChIP-Seq_K562_Human1.22858020
60KDM2B_26808549_Chip-Seq_DND41_Human1.22061526
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21605140
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21523685
63TP53_23651856_ChIP-Seq_MEFs_Mouse1.20155633
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19216838
65SPI1_23127762_ChIP-Seq_K562_Human1.19215402
66CDX2_20551321_ChIP-Seq_CACO-2_Human1.18989964
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18831387
68TCF7_22412390_ChIP-Seq_EML_Mouse1.18639116
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.18048006
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17998743
71RACK7_27058665_Chip-Seq_MCF-7_Human1.17563211
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17399216
73MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.17284352
74SMC3_22415368_ChIP-Seq_MEFs_Mouse1.16815910
75CJUN_26792858_Chip-Seq_BT549_Human1.15330998
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14200499
77JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13647551
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12640000
79STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11938778
80* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11886063
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11780248
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11259456
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10834475
84* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09298551
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09084861
86RUNX_20019798_ChIP-Seq_JUKART_Human1.08774710
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07367700
88SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05349122
89SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02257428
90KDM2B_26808549_Chip-Seq_K562_Human1.01759889
91EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01518950
92JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00463463
93BRD4_25478319_ChIP-Seq_HGPS_Human1.00420894
94RING1B_27294783_Chip-Seq_ESCs_Mouse0.99705873
95* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99251281
96TCF4_18268006_ChIP-ChIP_LS174T_Human0.99122116
97VDR_22108803_ChIP-Seq_LS180_Human0.98989803
98FOXO3_23340844_ChIP-Seq_DLD1_Human0.97792611
99SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97532050
100SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97532050
101CTCF_27219007_Chip-Seq_Bcells_Human0.97015311
102NCOR1_26117541_ChIP-Seq_K562_Human0.96908224
103SOX2_20726797_ChIP-Seq_SW620_Human0.96075437
104NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95662326
105EZH2_27304074_Chip-Seq_ESCs_Mouse0.94055823
106SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91828594
107MAF_26560356_Chip-Seq_TH1_Human0.91824323
108CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.91557764
109TP53_22127205_ChIP-Seq_IMR90_Human0.90551021
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90477529
111CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89943752
112P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89915525
113SOX11_22085726_ChIP-Seq_ESNs_Mouse0.88876743
114TP53_20018659_ChIP-ChIP_R1E_Mouse0.88734110
115TET1_21490601_ChIP-Seq_MESCs_Mouse0.88035039
116JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87732900
117* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87579925
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87505803
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86922264
120VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86666823
121KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86588300
122PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86529766
123RUNX1_27514584_Chip-Seq_MCF-7_Human0.85872788
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84952155
125ELK4_26923725_Chip-Seq_MESODERM_Mouse0.84565620
126KDM2B_26808549_Chip-Seq_JURKAT_Human0.84195500
127JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83769539
128GATA4_21415370_ChIP-Seq_HL-1_Mouse0.83041698
129MYC_27129775_Chip-Seq_CORNEA_Mouse0.82875086
130WT1_19549856_ChIP-ChIP_CCG9911_Human0.82724045
131FOXA2_19822575_ChIP-Seq_HepG2_Human0.82260535
132TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81174432
133DROSHA_22980978_ChIP-Seq_HELA_Human0.81028488
134NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.80827804
135UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.80701920
136RAD21_21589869_ChIP-Seq_MESCs_Mouse0.79779732
137* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.79686459
138ISL1_27105846_Chip-Seq_CPCs_Mouse0.79022068
139SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.78714819
140ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.78585890
141WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.78061628
142* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77149886
143SA1_22415368_ChIP-Seq_MEFs_Mouse0.77029517
144P300_27058665_Chip-Seq_ZR-75-30cells_Human0.75448041
145NR3C1_23031785_ChIP-Seq_PC12_Mouse0.73225780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0010368_abnormal_lymphatic_system6.13236258
2* MP0001879_abnormal_lymphatic_vessel4.77549858
3MP0005167_abnormal_blood-brain_barrier4.59478863
4MP0004084_abnormal_cardiac_muscle4.51028305
5MP0004272_abnormal_basement_membrane4.43260027
6MP0004215_abnormal_myocardial_fiber2.94105713
7MP0004036_abnormal_muscle_relaxation2.91521885
8MP0003724_increased_susceptibility_to2.88766791
9MP0002837_dystrophic_cardiac_calcinosis2.65379426
10MP0000751_myopathy2.62859301
11MP0006138_congestive_heart_failure2.48582355
12* MP0003828_pulmonary_edema2.35012228
13MP0005330_cardiomyopathy2.28506634
14MP0008775_abnormal_heart_ventricle2.26444401
15MP0003279_aneurysm2.25172321
16MP0006054_spinal_hemorrhage2.19066799
17MP0001544_abnormal_cardiovascular_syste2.10124088
18MP0005385_cardiovascular_system_phenoty2.10124088
19MP0000767_abnormal_smooth_muscle1.92088388
20MP0004130_abnormal_muscle_cell1.89854118
21MP0002933_joint_inflammation1.88147507
22MP0002972_abnormal_cardiac_muscle1.86637773
23MP0010630_abnormal_cardiac_muscle1.83768138
24MP0002138_abnormal_hepatobiliary_system1.78244703
25MP0000343_altered_response_to1.77173452
26MP0004085_abnormal_heartbeat1.72139500
27MP0000749_muscle_degeneration1.69645437
28MP0003566_abnormal_cell_adhesion1.66954868
29MP0005165_increased_susceptibility_to1.66934654
30MP0000013_abnormal_adipose_tissue1.65310218
31MP0002877_abnormal_melanocyte_morpholog1.64268596
32MP0005670_abnormal_white_adipose1.62830613
33MP0004484_altered_response_of1.61964776
34MP0003705_abnormal_hypodermis_morpholog1.60866818
35MP0010030_abnormal_orbit_morphology1.58848992
36MP0001958_emphysema1.53829524
37MP0004087_abnormal_muscle_fiber1.51924634
38MP0005620_abnormal_muscle_contractility1.51762985
39MP0000750_abnormal_muscle_regeneration1.49412925
40MP0004510_myositis1.45077499
41MP0003646_muscle_fatigue1.44639828
42MP0004147_increased_porphyrin_level1.44587874
43MP0002127_abnormal_cardiovascular_syste1.44534466
44* MP0002128_abnormal_blood_circulation1.43979515
45MP0002332_abnormal_exercise_endurance1.42807286
46MP0003191_abnormal_cellular_cholesterol1.38055259
47MP0000249_abnormal_blood_vessel1.36641238
48MP0005595_abnormal_vascular_smooth1.33098424
49MP0009278_abnormal_bone_marrow1.32297025
50MP0005084_abnormal_gallbladder_morpholo1.29661185
51MP0004782_abnormal_surfactant_physiolog1.27984185
52MP0000465_gastrointestinal_hemorrhage1.26641428
53* MP0002925_abnormal_cardiovascular_devel1.21699147
54MP0002106_abnormal_muscle_physiology1.20485874
55* MP0001614_abnormal_blood_vessel1.17527283
56MP0003567_abnormal_fetal_cardiomyocyte1.17518192
57MP0004145_abnormal_muscle_electrophysio1.17448689
58* MP0000266_abnormal_heart_morphology1.13673956
59MP0003300_gastrointestinal_ulcer1.13048989
60MP0004233_abnormal_muscle_weight1.09885093
61MP0003137_abnormal_impulse_conducting1.06851282
62MP0001849_ear_inflammation1.06682178
63MP0008438_abnormal_cutaneous_collagen1.05323089
64MP0000230_abnormal_systemic_arterial1.05018514
65MP0009697_abnormal_copulation1.03918098
66MP0005666_abnormal_adipose_tissue1.03681592
67MP0003868_abnormal_feces_composition0.98796465
68MP0005275_abnormal_skin_tensile0.97442538
69MP0004808_abnormal_hematopoietic_stem0.95860906
70MP0002295_abnormal_pulmonary_circulatio0.94024650
71MP0008004_abnormal_stomach_pH0.93708592
72MP0005369_muscle_phenotype0.90025554
73MP0003950_abnormal_plasma_membrane0.87086066
74MP0005623_abnormal_meninges_morphology0.86493798
75MP0003943_abnormal_hepatobiliary_system0.85192509
76MP0003303_peritoneal_inflammation0.84911799
77MP0005375_adipose_tissue_phenotype0.84097513
78MP0005360_urolithiasis0.81228545
79MP0001545_abnormal_hematopoietic_system0.81211515
80MP0005397_hematopoietic_system_phenotyp0.81211515
81MP0005409_darkened_coat_color0.79535790
82* MP0001784_abnormal_fluid_regulation0.77759101
83MP0001915_intracranial_hemorrhage0.77521107
84MP0001851_eye_inflammation0.77214194
85MP0000003_abnormal_adipose_tissue0.76466941
86MP0005085_abnormal_gallbladder_physiolo0.74385676
87MP0005319_abnormal_enzyme/_coenzyme0.73311973
88MP0000759_abnormal_skeletal_muscle0.72669387
89MP0008875_abnormal_xenobiotic_pharmacok0.71698323
90MP0004883_abnormal_blood_vessel0.71451121
91MP0010329_abnormal_lipoprotein_level0.71395361
92MP0005164_abnormal_response_to0.71166974
93MP0002932_abnormal_joint_morphology0.69677385
94MP0004185_abnormal_adipocyte_glucose0.68624814
95MP0000049_abnormal_middle_ear0.67919058
96MP0002269_muscular_atrophy0.67061162
97MP0009643_abnormal_urine_homeostasis0.66994291
98MP0003221_abnormal_cardiomyocyte_apopto0.66937685
99MP0009764_decreased_sensitivity_to0.64819883
100MP0003948_abnormal_gas_homeostasis0.64774779
101MP0003045_fibrosis0.64280707
102MP0003935_abnormal_craniofacial_develop0.63970971
103MP0002108_abnormal_muscle_morphology0.61959474
104MP0003075_altered_response_to0.58345743
105MP0003091_abnormal_cell_migration0.57953289
106MP0001756_abnormal_urination0.57702877
107MP0003941_abnormal_skin_development0.56113434
108MP0005187_abnormal_penis_morphology0.55777046
109MP0002088_abnormal_embryonic_growth/wei0.55026750
110MP0005365_abnormal_bile_salt0.54995969
111MP0003385_abnormal_body_wall0.54898466
112MP0000747_muscle_weakness0.54382781
113MP0003984_embryonic_growth_retardation0.54142532
114MP0004885_abnormal_endolymph0.51511311
115MP0002086_abnormal_extraembryonic_tissu0.51341036
116MP0002168_other_aberrant_phenotype0.50657877
117MP0009780_abnormal_chondrocyte_physiolo0.49994868
118MP0002896_abnormal_bone_mineralization0.49766627
119MP0006036_abnormal_mitochondrial_physio0.49703213
120MP0002092_abnormal_eye_morphology0.49546026
121MP0003633_abnormal_nervous_system0.45309973
122MP0005023_abnormal_wound_healing0.45024615
123MP0000613_abnormal_salivary_gland0.44878312
124MP0000467_abnormal_esophagus_morphology0.42831436
125MP0005508_abnormal_skeleton_morphology0.41226977
126MP0005058_abnormal_lysosome_morphology0.40589944
127MP0000733_abnormal_muscle_development0.40356329
128MP0001293_anophthalmia0.40155090
129MP0005166_decreased_susceptibility_to0.39766007

Predicted human phenotypes

RankGene SetZ-score
1Polycythemia (HP:0001901)6.24408233
2Spontaneous hematomas (HP:0007420)5.53380885
3Hematochezia (HP:0002573)5.43970900
4Ventricular tachycardia (HP:0004756)5.09060151
5Sudden death (HP:0001699)4.87257512
6Muscle fiber splitting (HP:0003555)4.50482974
7Atrial fibrillation (HP:0005110)4.18052626
8Esophageal varix (HP:0002040)4.12640115
9Supraventricular arrhythmia (HP:0005115)3.98910466
10Abnormality of the nasal mucosa (HP:0000433)3.94808801
11Broad metatarsal (HP:0001783)3.86517069
12Primary atrial arrhythmia (HP:0001692)3.85255275
13Lymphangioma (HP:0100764)3.82434219
14Increased connective tissue (HP:0009025)3.78137339
15Cerebral aneurysm (HP:0004944)3.76680603
16Cerebral hemorrhage (HP:0001342)3.72675246
17Nonimmune hydrops fetalis (HP:0001790)3.71270970
18Supraventricular tachycardia (HP:0004755)3.70463768
19Lipoatrophy (HP:0100578)3.65314075
20Arterial tortuosity (HP:0005116)3.58020864
21Right ventricular cardiomyopathy (HP:0011663)3.57010059
22Capillary hemangiomas (HP:0005306)3.54842465
23Visceral angiomatosis (HP:0100761)3.50673944
24Hyporeflexia of lower limbs (HP:0002600)3.45578395
25Absent hand (HP:0004050)3.42237774
26Atrioventricular block (HP:0001678)3.41403248
27Hemangiomatosis (HP:0007461)3.29497876
28Conjunctival telangiectasia (HP:0000524)3.26398149
29Vascular tortuosity (HP:0004948)3.23126741
30Overgrowth (HP:0001548)3.10146278
31Subaortic stenosis (HP:0001682)3.08185556
32Abnormality of the left ventricular outflow tract (HP:0011103)3.08185556
33Dilated cardiomyopathy (HP:0001644)3.00818443
34Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.96633128
35Short 4th metacarpal (HP:0010044)2.96633128
36Protrusio acetabuli (HP:0003179)2.95854149
37Exercise-induced myalgia (HP:0003738)2.94257637
38Difficulty running (HP:0009046)2.93410429
39Cavernous hemangioma (HP:0001048)2.91975663
40Deep venous thrombosis (HP:0002625)2.90830904
41Heart block (HP:0012722)2.90143569
42Asymmetric septal hypertrophy (HP:0001670)2.82538969
43Calf muscle hypertrophy (HP:0008981)2.80806652
44Syncope (HP:0001279)2.80125455
45Menorrhagia (HP:0000132)2.78601244
46Exercise-induced muscle cramps (HP:0003710)2.78343902
47Abnormality of the vasculature of the conjunctiva (HP:0008054)2.77205917
48Pulmonary artery stenosis (HP:0004415)2.77200522
49Myotonia (HP:0002486)2.77190666
50Aneurysm (HP:0002617)2.74925045
51Myoglobinuria (HP:0002913)2.73935131
52Vertebral clefting (HP:0008428)2.73919589
53Hip contracture (HP:0003273)2.72133640
54Abnormal atrioventricular conduction (HP:0005150)2.70787895
55Hemorrhage of the eye (HP:0011885)2.70207022
56Prolonged QT interval (HP:0001657)2.69415355
57Portal hypertension (HP:0001409)2.68271115
58Increased variability in muscle fiber diameter (HP:0003557)2.65881443
59Neonatal death (HP:0003811)2.63106847
60Palpitations (HP:0001962)2.56224368
61Abnormality of skeletal muscle fiber size (HP:0012084)2.54082920
62Premature rupture of membranes (HP:0001788)2.53710219
63Abnormal vertebral ossification (HP:0100569)2.50655266
64EMG: myopathic abnormalities (HP:0003458)2.48784453
65Bundle branch block (HP:0011710)2.45796402
66Hypoglycemic coma (HP:0001325)2.43208638
67Abnormality of the calf musculature (HP:0001430)2.41250288
68Muscle hypertrophy of the lower extremities (HP:0008968)2.40472998
69Abnormality of the hepatic vasculature (HP:0006707)2.38458594
70Aortic valve stenosis (HP:0001650)2.36938306
71Abnormality of the 4th metacarpal (HP:0010012)2.36144773
72Asymmetry of the thorax (HP:0001555)2.34567697
73Difficulty climbing stairs (HP:0003551)2.33570233
74Joint hemorrhage (HP:0005261)2.32143858
75Skull defect (HP:0001362)2.31778604
76Joint contractures involving the joints of the feet (HP:0100492)2.29709389
77Flexion contracture of toe (HP:0005830)2.29709389
78Stroke (HP:0001297)2.29475506
79Aortic aneurysm (HP:0004942)2.29406362
80Spinal rigidity (HP:0003306)2.28867947
81Mucosal telangiectasiae (HP:0100579)2.28479667
82Microcytic anemia (HP:0001935)2.27845791
83Limited hip movement (HP:0008800)2.19693234
84Abnormality of fatty-acid metabolism (HP:0004359)2.19472094
85Cervical subluxation (HP:0003308)2.17628777
86Abnormality of the intrinsic pathway (HP:0010989)2.16683846
87Ventricular arrhythmia (HP:0004308)2.14491440
88Porencephaly (HP:0002132)2.13469483
89Mesangial abnormality (HP:0001966)2.13158431
90Ectopia lentis (HP:0001083)2.12065791
91Aortic dissection (HP:0002647)2.11651730
92Lymphedema (HP:0001004)2.11150479
93Shallow orbits (HP:0000586)2.11117356
94Distal lower limb muscle weakness (HP:0009053)2.10787210
95Bulbous nose (HP:0000414)2.10219495
96Mitral valve prolapse (HP:0001634)2.07432386
97Impaired platelet aggregation (HP:0003540)2.07323121
98Abnormal platelet function (HP:0011869)2.07323121
99Rhabdomyolysis (HP:0003201)2.06981293
100Ventricular fibrillation (HP:0001663)2.04873901
101Centrally nucleated skeletal muscle fibers (HP:0003687)2.04454618
102Ketoacidosis (HP:0001993)2.01111526
103Pulmonary embolism (HP:0002204)2.00615193
104Trismus (HP:0000211)2.00284297
105Hypoplasia of the iris (HP:0007676)2.00058579
106Anterior segment dysgenesis (HP:0007700)1.96542302
107Coxa vara (HP:0002812)1.96085874
108Adactyly (HP:0009776)1.95815119
109Tetraparesis (HP:0002273)1.95750021
110Prolonged bleeding time (HP:0003010)1.95702701
111Wrist flexion contracture (HP:0001239)1.95138730
112Pulmonary hypertension (HP:0002092)1.94697751
113Growth hormone excess (HP:0000845)1.93961298
114Hydroureter (HP:0000072)1.93721411
115Venous insufficiency (HP:0005293)1.93578056
116Thrombophlebitis (HP:0004418)1.90314386
117Occipital encephalocele (HP:0002085)1.90275350
118Neoplasm of the oral cavity (HP:0100649)1.89286198
119Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87167532
120Dicarboxylic aciduria (HP:0003215)1.87167532
121Large hands (HP:0001176)1.87131177
122Venous abnormality (HP:0002624)1.86638093
123Epistaxis (HP:0000421)1.86497609
124Conjunctival hamartoma (HP:0100780)1.85729471
125Malignant hyperthermia (HP:0002047)1.85464807
126Wormian bones (HP:0002645)1.85258693
127Interstitial pulmonary disease (HP:0006530)1.83984780
128Areflexia of lower limbs (HP:0002522)1.81596259
129Pigmentary retinal degeneration (HP:0001146)1.80393329
130Congestive heart failure (HP:0001635)1.80134220
131Hemiplegia (HP:0002301)1.80081905
132Joint stiffness (HP:0001387)1.79689255
133Exotropia (HP:0000577)1.79478544
134Broad face (HP:0000283)1.79384728
135Abnormal EKG (HP:0003115)1.78155864
136Distal arthrogryposis (HP:0005684)1.78075306
137Polygenic inheritance (HP:0010982)1.77200796
138Facial diplegia (HP:0001349)1.76943900
139High pitched voice (HP:0001620)1.76678550
140Ketosis (HP:0001946)1.76432291
141Rectal prolapse (HP:0002035)1.75344099
142Lumbar hyperlordosis (HP:0002938)1.74551916
143Myocardial infarction (HP:0001658)1.73692371
144Congenital hip dislocation (HP:0001374)1.71673186
145Abnormality of the anterior chamber (HP:0000593)1.70199692
146Scotoma (HP:0000575)1.69954787
147Abnormality of the periventricular white matter (HP:0002518)1.69270932
148Coxa valga (HP:0002673)1.68085978

Predicted kinase interactions (KEA)

RankGene SetZ-score
1* TIE17.91896095
2KDR7.64875747
3TGFBR24.81220722
4TGFBR13.66688793
5FES3.14116378
6TRIB32.44069904
7RIPK12.38186907
8MYLK2.28496754
9TTN2.20515292
10PKN22.05351320
11ERN12.01390543
12EPHB21.84625136
13PTK2B1.83968551
14MAP2K31.83923955
15NTRK11.68708273
16BCKDK1.61293889
17FGFR41.50029544
18GRK11.48117878
19PTK61.40200417
20EPHB11.39097750
21DMPK1.36023100
22PRKG21.30886212
23PDK21.19257346
24LMTK21.14809710
25OBSCN1.11112840
26PDGFRA1.10247696
27MAP3K31.01137768
28MAPK120.99660792
29FER0.98475427
30PAK40.97884674
31PRKD10.94022325
32PHKG20.90273275
33PHKG10.90273275
34FGFR30.89570875
35INSRR0.88823378
36MAP4K10.82862810
37LRRK20.81834532
38PDK30.81430738
39PDK40.81430738
40JAK30.79162008
41FGFR20.78046781
42KIT0.77253974
43ILK0.72678951
44PRKAA20.69958370
45TEC0.67996475
46MAP3K70.66829129
47STK240.66730692
48RPS6KA20.64803739
49WNK40.63879513
50MAP3K110.63051174
51MET0.61802783
52MOS0.59948115
53CAMK40.59197011
54PRKCH0.58128731
55MAP3K10.54916722
56PIK3CA0.54261232
57FLT30.53030463
58CSK0.52916177
59MAPKAPK30.51611215
60MARK20.51138403
61NEK90.50175917
62MAP3K130.49484066
63MAPK70.49438641
64TBK10.49213060
65HCK0.46763246
66MUSK0.46322404
67PINK10.45835889
68PTK20.45682974
69JAK10.43848253
70ZAP700.43814841
71ROCK20.43237884
72RET0.42207688
73SIK10.41240786
74CAMK1D0.40934741
75BMPR1B0.39261110
76PDPK10.39118129
77JAK20.38222376
78MAP2K20.37448326
79MAPK150.36820604
80SCYL20.36465282
81PRKD30.36258773
82GRK50.35136034
83MAPKAPK50.34478040
84PDGFRB0.34293487
85IGF1R0.32791795
86TYRO30.31922604
87LATS20.31894645
88TRPM70.31434159
89STK100.31304558
90EPHA30.30728210
91DAPK30.29494071
92PRKD20.29077035
93PRKAA10.28140601
94EEF2K0.28125414
95IRAK30.28077696
96TYK20.27673277
97GRK70.27565586
98SRC0.27218064
99GSK3A0.26357333
100PAK60.26172886
101EGFR0.25160053
102EPHA20.24696785
103LCK0.24638500
104MAPK40.24114196
105ROCK10.23728237
106BTK0.23104988
107DAPK20.22771126
108CAMK10.22340307
109INSR0.21184575
110PDK10.20966795
111LATS10.20604969
112RPS6KC10.20364313
113RPS6KL10.20364313
114MAP2K10.19715816
115MATK0.19673863
116RPS6KA60.19406502
117PRKACB0.18185977
118PRKCE0.18095533
119ITK0.17765317
120MAP3K100.16921984
121LIMK10.16902502
122MAP3K60.16572142
123NLK0.16452981
124NTRK30.15759601
125ABL20.14971092
126CDK90.14849717
127PAK20.14060807
128CSNK1G10.13910023
129ARAF0.13609985
130AKT20.13059384
131SGK20.12138612
132ERBB40.12051310
133MTOR0.11561271
134SGK2230.10371242
135SGK4940.10371242
136TESK10.10075308
137SGK30.09533188
138PIK3CG0.09430424

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005314.23942822
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.54921716
3Fatty acid degradation_Homo sapiens_hsa000713.07181646
4ECM-receptor interaction_Homo sapiens_hsa045122.78821113
5Dilated cardiomyopathy_Homo sapiens_hsa054142.67724659
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.67531071
7Propanoate metabolism_Homo sapiens_hsa006402.67110258
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.48177828
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27653782
10Caffeine metabolism_Homo sapiens_hsa002322.18843192
11Focal adhesion_Homo sapiens_hsa045102.11261095
12Fatty acid metabolism_Homo sapiens_hsa012122.06236578
13PPAR signaling pathway_Homo sapiens_hsa033201.98537577
14Arginine biosynthesis_Homo sapiens_hsa002201.85228138
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.81070307
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.80262119
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.78286293
18Complement and coagulation cascades_Homo sapiens_hsa046101.76636974
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.72220494
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.63810426
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.59412544
22Tryptophan metabolism_Homo sapiens_hsa003801.52510699
23Platelet activation_Homo sapiens_hsa046111.52290513
24Insulin resistance_Homo sapiens_hsa049311.49875595
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.45779897
26Small cell lung cancer_Homo sapiens_hsa052221.40920821
27Notch signaling pathway_Homo sapiens_hsa043301.39151701
28Adherens junction_Homo sapiens_hsa045201.25125672
29Amoebiasis_Homo sapiens_hsa051461.25031080
30Cardiac muscle contraction_Homo sapiens_hsa042601.22765713
31Carbon metabolism_Homo sapiens_hsa012001.22057346
32Viral myocarditis_Homo sapiens_hsa054161.21158975
33Adipocytokine signaling pathway_Homo sapiens_hsa049201.21054450
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19657959
35Phospholipase D signaling pathway_Homo sapiens_hsa040721.18977372
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17645288
37Bile secretion_Homo sapiens_hsa049761.17552162
38Dorso-ventral axis formation_Homo sapiens_hsa043201.16508713
39Rap1 signaling pathway_Homo sapiens_hsa040151.11567726
40TGF-beta signaling pathway_Homo sapiens_hsa043501.10731839
41Prion diseases_Homo sapiens_hsa050201.08047083
42Malaria_Homo sapiens_hsa051441.07655077
43Fatty acid elongation_Homo sapiens_hsa000621.05572159
44Protein digestion and absorption_Homo sapiens_hsa049741.03865847
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02496091
46Bladder cancer_Homo sapiens_hsa052191.01103533
47Toxoplasmosis_Homo sapiens_hsa051451.00370304
48beta-Alanine metabolism_Homo sapiens_hsa004100.98940916
49PI3K-Akt signaling pathway_Homo sapiens_hsa041510.98532454
50Butanoate metabolism_Homo sapiens_hsa006500.93895982
51Pyruvate metabolism_Homo sapiens_hsa006200.93532386
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93222703
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.92361783
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91887131
55VEGF signaling pathway_Homo sapiens_hsa043700.91790928
56Lysine degradation_Homo sapiens_hsa003100.90661386
57African trypanosomiasis_Homo sapiens_hsa051430.90181573
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.88248038
59Renin secretion_Homo sapiens_hsa049240.88049299
60Other glycan degradation_Homo sapiens_hsa005110.87842530
61Ovarian steroidogenesis_Homo sapiens_hsa049130.86808791
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85259052
63Proteoglycans in cancer_Homo sapiens_hsa052050.84354841
64Endocytosis_Homo sapiens_hsa041440.81516012
65Tight junction_Homo sapiens_hsa045300.80827137
66Staphylococcus aureus infection_Homo sapiens_hsa051500.80166035
67ABC transporters_Homo sapiens_hsa020100.79852905
68HIF-1 signaling pathway_Homo sapiens_hsa040660.79604976
69Nitrogen metabolism_Homo sapiens_hsa009100.78066151
70Peroxisome_Homo sapiens_hsa041460.77858547
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75788358
72GnRH signaling pathway_Homo sapiens_hsa049120.75578800
73Shigellosis_Homo sapiens_hsa051310.73861441
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70685542
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67826670
76Starch and sucrose metabolism_Homo sapiens_hsa005000.66779823
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66714926
78MAPK signaling pathway_Homo sapiens_hsa040100.65323766
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65250693
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63332584
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62564188
82Rheumatoid arthritis_Homo sapiens_hsa053230.62287373
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62067734
84Serotonergic synapse_Homo sapiens_hsa047260.59152532
85Morphine addiction_Homo sapiens_hsa050320.58811420
86Pathways in cancer_Homo sapiens_hsa052000.58577749
87Pancreatic cancer_Homo sapiens_hsa052120.58369183
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58096308
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57368031
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57337538
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56420628
92Glutamatergic synapse_Homo sapiens_hsa047240.55642204
93Chronic myeloid leukemia_Homo sapiens_hsa052200.54914524
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.54683823
95Fat digestion and absorption_Homo sapiens_hsa049750.54157565
96Glucagon signaling pathway_Homo sapiens_hsa049220.53227564
97MicroRNAs in cancer_Homo sapiens_hsa052060.51405826
98Melanogenesis_Homo sapiens_hsa049160.50566720
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50535862
100TNF signaling pathway_Homo sapiens_hsa046680.50156216
101AMPK signaling pathway_Homo sapiens_hsa041520.49277540
102Hippo signaling pathway_Homo sapiens_hsa043900.49130053
103Renin-angiotensin system_Homo sapiens_hsa046140.48613671
104Vitamin digestion and absorption_Homo sapiens_hsa049770.48062478
105Insulin signaling pathway_Homo sapiens_hsa049100.47824124
106Arginine and proline metabolism_Homo sapiens_hsa003300.47408330
107Lysosome_Homo sapiens_hsa041420.45235322
108Choline metabolism in cancer_Homo sapiens_hsa052310.45097003
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44158097
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43071560
111Pertussis_Homo sapiens_hsa051330.42020070
112Hematopoietic cell lineage_Homo sapiens_hsa046400.42005204
113Circadian entrainment_Homo sapiens_hsa047130.41053908
114Basal cell carcinoma_Homo sapiens_hsa052170.40915524
115Ras signaling pathway_Homo sapiens_hsa040140.38221771
116cAMP signaling pathway_Homo sapiens_hsa040240.38065490
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37429859
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37417920
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36904943
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.36872941
121Osteoclast differentiation_Homo sapiens_hsa043800.36269003
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.36173592
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35341404
124Sulfur relay system_Homo sapiens_hsa041220.34101287
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33930366
126Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33431235
127Long-term depression_Homo sapiens_hsa047300.33179641
128Thyroid hormone synthesis_Homo sapiens_hsa049180.32085655
129Oxytocin signaling pathway_Homo sapiens_hsa049210.31145018
130Gap junction_Homo sapiens_hsa045400.30965313
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30859584
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.30569081
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30297549
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30152386
135Leishmaniasis_Homo sapiens_hsa051400.29205489
136Salivary secretion_Homo sapiens_hsa049700.29078539
137Glioma_Homo sapiens_hsa052140.28897681
138Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28823429
139Calcium signaling pathway_Homo sapiens_hsa040200.28786981
140Glycerolipid metabolism_Homo sapiens_hsa005610.28497810
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28460745
142Gastric acid secretion_Homo sapiens_hsa049710.28104666
143Estrogen signaling pathway_Homo sapiens_hsa049150.27920450
144Salmonella infection_Homo sapiens_hsa051320.27636680
145Renal cell carcinoma_Homo sapiens_hsa052110.26789612
146Axon guidance_Homo sapiens_hsa043600.26557057

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