

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | negative regulation of phagocytosis (GO:0050765) | 5.32487155 |
| 2 | respiratory burst (GO:0045730) | 5.24416216 |
| 3 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 5.08588436 |
| 4 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 5.08588436 |
| 5 | modulation by symbiont of host immune response (GO:0052553) | 5.08588436 |
| 6 | positive regulation by symbiont of host defense response (GO:0052509) | 5.08588436 |
| 7 | modulation by symbiont of host defense response (GO:0052031) | 5.08588436 |
| 8 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 5.08588436 |
| 9 | neutrophil activation involved in immune response (GO:0002283) | 5.08513618 |
| 10 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.05586375 |
| 11 | negative regulation of interleukin-12 production (GO:0032695) | 4.82401019 |
| 12 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.80598052 |
| 13 | neutrophil mediated immunity (GO:0002446) | 4.79169373 |
| 14 | macrophage activation involved in immune response (GO:0002281) | 4.52522481 |
| 15 | cellular extravasation (GO:0045123) | 4.51944554 |
| 16 | regulation of interferon-beta biosynthetic process (GO:0045357) | 4.47677595 |
| 17 | immunoglobulin mediated immune response (GO:0016064) | 4.39220146 |
| 18 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 4.35541794 |
| 19 | T-helper 1 type immune response (GO:0042088) | 4.23951840 |
| 20 | positive regulation of B cell differentiation (GO:0045579) | 4.20025457 |
| 21 | microglial cell activation (GO:0001774) | 4.14528269 |
| 22 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 4.12786121 |
| 23 | response to peptidoglycan (GO:0032494) | 4.11598646 |
| 24 | pinocytosis (GO:0006907) | 4.00540649 |
| 25 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.90389250 |
| 26 | detection of other organism (GO:0098543) | 3.90249839 |
| 27 | myeloid cell activation involved in immune response (GO:0002275) | 3.89862903 |
| 28 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 3.86367813 |
| 29 | regulation of hypersensitivity (GO:0002883) | 3.85604296 |
| 30 | NIK/NF-kappaB signaling (GO:0038061) | 3.84389618 |
| 31 | neutrophil activation (GO:0042119) | 3.81487366 |
| 32 | G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589) | 3.80704922 |
| 33 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.78531513 |
| 34 | negative regulation of growth of symbiont in host (GO:0044130) | 3.77676315 |
| 35 | negative regulation of growth of symbiont involved in interaction with host (GO:0044146) | 3.77676315 |
| 36 | modulation of growth of symbiont involved in interaction with host (GO:0044144) | 3.77676315 |
| 37 | regulation of growth of symbiont in host (GO:0044126) | 3.77676315 |
| 38 | response to fungus (GO:0009620) | 3.75974597 |
| 39 | negative regulation of granulocyte differentiation (GO:0030853) | 3.74765330 |
| 40 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.73816820 |
| 41 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.73816820 |
| 42 | detection of bacterium (GO:0016045) | 3.73566813 |
| 43 | negative regulation of cell killing (GO:0031342) | 3.73307428 |
| 44 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 3.73307428 |
| 45 | mast cell activation (GO:0045576) | 3.72272261 |
| 46 | cellular response to zinc ion (GO:0071294) | 3.70512162 |
| 47 | leukocyte mediated cytotoxicity (GO:0001909) | 3.67331581 |
| 48 | positive regulation of interferon-alpha production (GO:0032727) | 3.64345997 |
| 49 | glycolipid catabolic process (GO:0019377) | 3.62673570 |
| 50 | myeloid leukocyte mediated immunity (GO:0002444) | 3.62341662 |
| 51 | granulocyte activation (GO:0036230) | 3.56253974 |
| 52 | regulation of B cell differentiation (GO:0045577) | 3.53709464 |
| 53 | positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 3.49592021 |
| 54 | regulation of mast cell activation (GO:0033003) | 3.47814381 |
| 55 | B cell receptor signaling pathway (GO:0050853) | 3.47521880 |
| 56 | positive regulation of myeloid leukocyte mediated immunity (GO:0002888) | 3.47148899 |
| 57 | response to muramyl dipeptide (GO:0032495) | 3.46993644 |
| 58 | positive regulation of leukocyte degranulation (GO:0043302) | 3.45394619 |
| 59 | regulation of mast cell degranulation (GO:0043304) | 3.44400776 |
| 60 | reactive oxygen species biosynthetic process (GO:1903409) | 3.42988307 |
| 61 | negative thymic T cell selection (GO:0045060) | 3.42462200 |
| 62 | regulation of interferon-alpha production (GO:0032647) | 3.42390685 |
| 63 | regulation of vitamin D biosynthetic process (GO:0060556) | 3.41047216 |
| 64 | disruption of cells of other organism involved in symbiotic interaction (GO:0051818) | 3.40759338 |
| 65 | killing of cells in other organism involved in symbiotic interaction (GO:0051883) | 3.40759338 |
| 66 | negative regulation of inflammatory response to antigenic stimulus (GO:0002862) | 3.39363650 |
| 67 | regulation of gamma-delta T cell activation (GO:0046643) | 3.39302464 |
| 68 | macrophage activation (GO:0042116) | 3.39056350 |
| 69 | negative regulation of erythrocyte differentiation (GO:0045647) | 3.37986359 |
| 70 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 3.36650979 |
| 71 | detection of external biotic stimulus (GO:0098581) | 3.31962803 |
| 72 | B cell mediated immunity (GO:0019724) | 3.31869684 |
| 73 | mannose metabolic process (GO:0006013) | 3.28366348 |
| 74 | positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725) | 3.28009407 |
| 75 | positive regulation of antigen processing and presentation (GO:0002579) | 3.26799314 |
| 76 | positive regulation of type 2 immune response (GO:0002830) | 3.26301087 |
| 77 | regulation of T cell tolerance induction (GO:0002664) | 3.24933740 |
| 78 | response to host immune response (GO:0052572) | 3.23042575 |
| 79 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.23042575 |
| 80 | negative regulation of B cell proliferation (GO:0030889) | 3.22136231 |
| 81 | production of molecular mediator involved in inflammatory response (GO:0002532) | 3.21084151 |
| 82 | regulation of regulated secretory pathway (GO:1903305) | 3.21026305 |
| 83 | dendritic cell differentiation (GO:0097028) | 3.20332000 |
| 84 | ceramide catabolic process (GO:0046514) | 3.18986455 |
| 85 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.16980459 |
| 86 | regulation of mast cell activation involved in immune response (GO:0033006) | 3.16206675 |
| 87 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 3.15845704 |
| 88 | myeloid dendritic cell differentiation (GO:0043011) | 3.15797433 |
| 89 | positive regulation of mast cell activation (GO:0033005) | 3.14771484 |
| 90 | regulation of tolerance induction (GO:0002643) | 3.14109604 |
| 91 | negative T cell selection (GO:0043383) | 3.13667325 |
| 92 | myeloid dendritic cell activation (GO:0001773) | 3.13585306 |
| 93 | positive regulation of cellular amide metabolic process (GO:0034250) | 3.12719498 |
| 94 | defense response to protozoan (GO:0042832) | 3.10189085 |
| 95 | detection of molecule of bacterial origin (GO:0032490) | 3.09875097 |
| 96 | oligosaccharide catabolic process (GO:0009313) | 3.09229654 |
| 97 | cellular response to exogenous dsRNA (GO:0071360) | 3.07166456 |
| 98 | myeloid leukocyte activation (GO:0002274) | 3.06711684 |
| 99 | cellular response to thyroid hormone stimulus (GO:0097067) | 3.04790757 |
| 100 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.04591912 |
| 101 | regulation of leukocyte degranulation (GO:0043300) | 3.03647662 |
| 102 | detection of biotic stimulus (GO:0009595) | 3.03374741 |
| 103 | positive regulation of monocyte chemotaxis (GO:0090026) | 3.01682754 |
| 104 | positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557) | 3.01002761 |
| 105 | leukotriene metabolic process (GO:0006691) | 3.00183807 |
| 106 | leukocyte degranulation (GO:0043299) | 2.99324670 |
| 107 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 2.99226928 |
| 108 | response to host (GO:0075136) | 2.99226928 |
| 109 | response to host defenses (GO:0052200) | 2.99226928 |
| 110 | positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516) | 2.99193582 |
| 111 | defense response to fungus (GO:0050832) | 2.99051013 |
| 112 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 2.98416755 |
| 113 | G-protein coupled purinergic receptor signaling pathway (GO:0035588) | 2.98078165 |
| 114 | germinal center formation (GO:0002467) | 2.96134799 |
| 115 | macrophage differentiation (GO:0030225) | 2.95031509 |
| 116 | T cell migration (GO:0072678) | 2.94185679 |
| 117 | lymphocyte chemotaxis (GO:0048247) | 2.94119112 |
| 118 | superoxide anion generation (GO:0042554) | 2.94077969 |
| 119 | response to protozoan (GO:0001562) | 2.92584519 |
| 120 | regulation of type 2 immune response (GO:0002828) | 2.92218134 |
| 121 | mast cell degranulation (GO:0043303) | 2.91951956 |
| 122 | mast cell activation involved in immune response (GO:0002279) | 2.91951956 |
| 123 | regulation of interleukin-12 production (GO:0032655) | 2.91683834 |
| 124 | negative regulation of mast cell activation (GO:0033004) | 2.91055679 |
| 125 | angiogenesis involved in wound healing (GO:0060055) | 2.90368000 |
| 126 | regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645) | 2.89804637 |
| 127 | positive regulation of gamma-delta T cell activation (GO:0046645) | 2.89603398 |
| 128 | negative regulation of interleukin-17 production (GO:0032700) | 2.89054640 |
| 129 | negative regulation of T cell mediated immunity (GO:0002710) | 2.89000663 |
| 130 | positive regulation of interferon-beta production (GO:0032728) | 2.86987282 |
| 131 | positive regulation of mast cell degranulation (GO:0043306) | 2.86853382 |
| 132 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 2.86853382 |
| 133 | regulation of inflammatory response to antigenic stimulus (GO:0002861) | 2.86799544 |
| 134 | cellular response to interferon-gamma (GO:0071346) | 2.86535912 |
| 135 | dendritic cell chemotaxis (GO:0002407) | 2.85488581 |
| 136 | dendritic cell migration (GO:0036336) | 2.84689126 |
| 137 | regulation of antigen processing and presentation (GO:0002577) | 2.84644581 |
| 138 | actin nucleation (GO:0045010) | 2.84623721 |
| 139 | regulation of vitamin metabolic process (GO:0030656) | 2.83484067 |
| 140 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 2.83268905 |
| 141 | regulation of mononuclear cell migration (GO:0071675) | 2.82825242 |
| 142 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.82140330 |
| 143 | regulation of T-helper 2 cell differentiation (GO:0045628) | 2.81349237 |
| 144 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.78158853 |
| 145 | glycosphingolipid catabolic process (GO:0046479) | 2.77549318 |
| 146 | positive regulation of chemokine secretion (GO:0090197) | 2.77517337 |
| 147 | megakaryocyte development (GO:0035855) | 2.77078473 |
| 148 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 2.74913848 |
| 149 | lipoxygenase pathway (GO:0019372) | 2.72945759 |
| 150 | B cell homeostasis (GO:0001782) | 2.72384956 |
| 151 | regulation of monocyte chemotaxis (GO:0090025) | 2.72100128 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.87294753 |
| 2 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 5.23450043 |
| 3 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 4.29794926 |
| 4 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 4.26860234 |
| 5 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.67228868 |
| 6 | * IRF8_27001747_Chip-Seq_BMDM_Mouse | 3.62835551 |
| 7 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 3.47049385 |
| 8 | * SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.39699954 |
| 9 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.23653055 |
| 10 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.15678355 |
| 11 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.10330783 |
| 12 | * NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.01036219 |
| 13 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.96530985 |
| 14 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.80871353 |
| 15 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.78358288 |
| 16 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.69640876 |
| 17 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.63401263 |
| 18 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.62438265 |
| 19 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.60629617 |
| 20 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 2.52774665 |
| 21 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.45077218 |
| 22 | VDR_24763502_ChIP-Seq_THP-1_Human | 2.32941050 |
| 23 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.27536904 |
| 24 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.23331395 |
| 25 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.13650465 |
| 26 | GATA1_22025678_ChIP-Seq_K562_Human | 2.10292820 |
| 27 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.09143394 |
| 28 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.06464978 |
| 29 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 2.05983937 |
| 30 | MYC_22102868_ChIP-Seq_BL_Human | 2.04695798 |
| 31 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.04203932 |
| 32 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.02220034 |
| 33 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 2.00958005 |
| 34 | MYB_26560356_Chip-Seq_TH2_Human | 1.98653574 |
| 35 | SPI1_23127762_ChIP-Seq_K562_Human | 1.87256537 |
| 36 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.84584583 |
| 37 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.82023726 |
| 38 | * LXR_22292898_ChIP-Seq_THP-1_Human | 1.80533026 |
| 39 | MAF_26560356_Chip-Seq_TH1_Human | 1.78511436 |
| 40 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.76152801 |
| 41 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.75051285 |
| 42 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.73877173 |
| 43 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.72967046 |
| 44 | MYB_26560356_Chip-Seq_TH1_Human | 1.70167871 |
| 45 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.70160202 |
| 46 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.66953378 |
| 47 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.63583640 |
| 48 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.56665738 |
| 49 | UTX_26944678_Chip-Seq_JUKART_Human | 1.53283662 |
| 50 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.53260810 |
| 51 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.52900592 |
| 52 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.51540298 |
| 53 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.48066681 |
| 54 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.45851282 |
| 55 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.45682672 |
| 56 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.45251724 |
| 57 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.44484811 |
| 58 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.37995116 |
| 59 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.37170363 |
| 60 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.35591812 |
| 61 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.35542177 |
| 62 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.34910503 |
| 63 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.33688260 |
| 64 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.33533932 |
| 65 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.31865061 |
| 66 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.30264221 |
| 67 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.28785064 |
| 68 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.25893732 |
| 69 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.25382275 |
| 70 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.24499076 |
| 71 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.20627407 |
| 72 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.20315757 |
| 73 | GATA1_19941826_ChIP-Seq_K562_Human | 1.18243447 |
| 74 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.17173087 |
| 75 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.11718522 |
| 76 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.08794585 |
| 77 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.08276177 |
| 78 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.08028687 |
| 79 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.07262056 |
| 80 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.07198360 |
| 81 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.06340099 |
| 82 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.06326868 |
| 83 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.05233935 |
| 84 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.04771584 |
| 85 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.02904771 |
| 86 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.02848712 |
| 87 | GATA3_26560356_Chip-Seq_TH2_Human | 1.02577913 |
| 88 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.00565270 |
| 89 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.00553430 |
| 90 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.00511976 |
| 91 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.00403223 |
| 92 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.99627843 |
| 93 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.99582229 |
| 94 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.99384869 |
| 95 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 0.94496140 |
| 96 | MAF_26560356_Chip-Seq_TH2_Human | 0.94349878 |
| 97 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.94014665 |
| 98 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.93970059 |
| 99 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.93304101 |
| 100 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.92908020 |
| 101 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.92418835 |
| 102 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.92334730 |
| 103 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.90573757 |
| 104 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.90026922 |
| 105 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.89153250 |
| 106 | * SPI1_20517297_ChIP-Seq_HL60_Human | 0.89099514 |
| 107 | * GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.87366556 |
| 108 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.86973861 |
| 109 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 0.86333826 |
| 110 | FOXP3_21729870_ChIP-Seq_TREG_Human | 0.86124629 |
| 111 | GATA2_19941826_ChIP-Seq_K562_Human | 0.83640103 |
| 112 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.82833391 |
| 113 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.82491684 |
| 114 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.82361770 |
| 115 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 0.79264466 |
| 116 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.78549747 |
| 117 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.77006749 |
| 118 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.76988727 |
| 119 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.75288998 |
| 120 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.75232612 |
| 121 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 0.74667887 |
| 122 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.74458359 |
| 123 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.73772287 |
| 124 | ETS1_22383799_ChIP-Seq_G1ME_Mouse | 0.70202366 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 4.78181221 |
| 2 | MP0003436_decreased_susceptibility_to | 3.40999342 |
| 3 | MP0003303_peritoneal_inflammation | 3.35465518 |
| 4 | MP0002419_abnormal_innate_immunity | 3.21079191 |
| 5 | MP0002148_abnormal_hypersensitivity_rea | 3.02207633 |
| 6 | MP0002396_abnormal_hematopoietic_system | 2.81900020 |
| 7 | MP0005464_abnormal_platelet_physiology | 2.80545133 |
| 8 | MP0005058_abnormal_lysosome_morphology | 2.75028354 |
| 9 | MP0009785_altered_susceptibility_to | 2.74425577 |
| 10 | MP0005025_abnormal_response_to | 2.73032659 |
| 11 | MP0005000_abnormal_immune_tolerance | 2.67873739 |
| 12 | MP0002452_abnormal_antigen_presenting | 2.66941904 |
| 13 | MP0003172_abnormal_lysosome_physiology | 2.60317517 |
| 14 | MP0005671_abnormal_response_to | 2.54340459 |
| 15 | MP0001800_abnormal_humoral_immune | 2.52550500 |
| 16 | MP0006082_CNS_inflammation | 2.44017590 |
| 17 | MP0001819_abnormal_immune_cell | 2.39947978 |
| 18 | MP0002420_abnormal_adaptive_immunity | 2.39376430 |
| 19 | MP0002723_abnormal_immune_serum | 2.38264980 |
| 20 | MP0003191_abnormal_cellular_cholesterol | 2.29181649 |
| 21 | MP0001790_abnormal_immune_system | 2.16079225 |
| 22 | MP0005387_immune_system_phenotype | 2.16079225 |
| 23 | MP0000685_abnormal_immune_system | 2.10294289 |
| 24 | MP0002398_abnormal_bone_marrow | 1.95305638 |
| 25 | MP0009333_abnormal_splenocyte_physiolog | 1.91222713 |
| 26 | MP0000716_abnormal_immune_system | 1.89692952 |
| 27 | MP0002166_altered_tumor_susceptibility | 1.87824611 |
| 28 | MP0002405_respiratory_system_inflammati | 1.87546025 |
| 29 | MP0001853_heart_inflammation | 1.87226473 |
| 30 | MP0003724_increased_susceptibility_to | 1.86297772 |
| 31 | MP0003183_abnormal_peptide_metabolism | 1.81852721 |
| 32 | MP0000343_altered_response_to | 1.78408095 |
| 33 | MP0001845_abnormal_inflammatory_respons | 1.76287778 |
| 34 | MP0000689_abnormal_spleen_morphology | 1.76274368 |
| 35 | MP0003300_gastrointestinal_ulcer | 1.70825281 |
| 36 | MP0001533_abnormal_skeleton_physiology | 1.69833339 |
| 37 | MP0002006_tumorigenesis | 1.69713406 |
| 38 | MP0005451_abnormal_body_composition | 1.69174836 |
| 39 | MP0008057_abnormal_DNA_replication | 1.68796853 |
| 40 | MP0004808_abnormal_hematopoietic_stem | 1.65669146 |
| 41 | MP0002429_abnormal_blood_cell | 1.64290024 |
| 42 | MP0002722_abnormal_immune_system | 1.63891875 |
| 43 | MP0005174_abnormal_tail_pigmentation | 1.63751892 |
| 44 | MP0000465_gastrointestinal_hemorrhage | 1.63748741 |
| 45 | MP0010307_abnormal_tumor_latency | 1.61299404 |
| 46 | MP0010155_abnormal_intestine_physiology | 1.60189684 |
| 47 | MP0001545_abnormal_hematopoietic_system | 1.58719936 |
| 48 | MP0005397_hematopoietic_system_phenotyp | 1.58719936 |
| 49 | MP0000490_abnormal_crypts_of | 1.53117141 |
| 50 | MP0008469_abnormal_protein_level | 1.49177235 |
| 51 | MP0003693_abnormal_embryo_hatching | 1.47634618 |
| 52 | MP0009840_abnormal_foam_cell | 1.45647284 |
| 53 | MP0003075_altered_response_to | 1.44839532 |
| 54 | MP0003690_abnormal_glial_cell | 1.43413998 |
| 55 | MP0000858_altered_metastatic_potential | 1.41488619 |
| 56 | MP0010094_abnormal_chromosome_stability | 1.38454450 |
| 57 | MP0002139_abnormal_hepatobiliary_system | 1.32413872 |
| 58 | MP0003763_abnormal_thymus_physiology | 1.31411932 |
| 59 | MP0002138_abnormal_hepatobiliary_system | 1.29514831 |
| 60 | MP0005075_abnormal_melanosome_morpholog | 1.25469513 |
| 61 | MP0003111_abnormal_nucleus_morphology | 1.24974450 |
| 62 | MP0009278_abnormal_bone_marrow | 1.24260542 |
| 63 | MP0000015_abnormal_ear_pigmentation | 1.22972639 |
| 64 | MP0001851_eye_inflammation | 1.22967260 |
| 65 | MP0008260_abnormal_autophagy | 1.22377216 |
| 66 | MP0009764_decreased_sensitivity_to | 1.22126914 |
| 67 | MP0006054_spinal_hemorrhage | 1.20914814 |
| 68 | MP0001873_stomach_inflammation | 1.13295470 |
| 69 | MP0000569_abnormal_digit_pigmentation | 1.13023822 |
| 70 | MP0005310_abnormal_salivary_gland | 1.11687087 |
| 71 | MP0004947_skin_inflammation | 1.11533763 |
| 72 | MP0008007_abnormal_cellular_replicative | 1.10235041 |
| 73 | MP0000703_abnormal_thymus_morphology | 1.09519953 |
| 74 | MP0003077_abnormal_cell_cycle | 1.09151436 |
| 75 | MP0003448_altered_tumor_morphology | 1.07619376 |
| 76 | MP0003806_abnormal_nucleotide_metabolis | 1.07061802 |
| 77 | MP0003329_amyloid_beta_deposits | 1.04676170 |
| 78 | MP0005166_decreased_susceptibility_to | 1.01428790 |
| 79 | MP0008004_abnormal_stomach_pH | 0.98144681 |
| 80 | MP0005167_abnormal_blood-brain_barrier | 0.97539474 |
| 81 | MP0003866_abnormal_defecation | 0.95821489 |
| 82 | MP0002019_abnormal_tumor_incidence | 0.94435949 |
| 83 | MP0004510_myositis | 0.94005400 |
| 84 | MP0002998_abnormal_bone_remodeling | 0.93478620 |
| 85 | MP0003656_abnormal_erythrocyte_physiolo | 0.92825861 |
| 86 | MP0000249_abnormal_blood_vessel | 0.90195530 |
| 87 | MP0002877_abnormal_melanocyte_morpholog | 0.89510329 |
| 88 | MP0000604_amyloidosis | 0.86985105 |
| 89 | MP0002095_abnormal_skin_pigmentation | 0.85963770 |
| 90 | MP0003453_abnormal_keratinocyte_physiol | 0.85820919 |
| 91 | MP0003091_abnormal_cell_migration | 0.85513461 |
| 92 | MP0009763_increased_sensitivity_to | 0.85115055 |
| 93 | MP0003566_abnormal_cell_adhesion | 0.83796285 |
| 94 | MP0008058_abnormal_DNA_repair | 0.82418832 |
| 95 | MP0005164_abnormal_response_to | 0.82037384 |
| 96 | MP0005076_abnormal_cell_differentiation | 0.81941896 |
| 97 | MP0001915_intracranial_hemorrhage | 0.80597180 |
| 98 | MP0000920_abnormal_myelination | 0.80562461 |
| 99 | MP0002254_reproductive_system_inflammat | 0.79809122 |
| 100 | MP0004883_abnormal_blood_vessel | 0.79749005 |
| 101 | MP0000371_diluted_coat_color | 0.78278363 |
| 102 | MP0008873_increased_physiological_sensi | 0.78059482 |
| 103 | MP0003828_pulmonary_edema | 0.77909419 |
| 104 | MP0001542_abnormal_bone_strength | 0.76503549 |
| 105 | MP0001663_abnormal_digestive_system | 0.74813389 |
| 106 | MP0004782_abnormal_surfactant_physiolog | 0.74390077 |
| 107 | MP0001986_abnormal_taste_sensitivity | 0.72834419 |
| 108 | MP0000313_abnormal_cell_death | 0.71330680 |
| 109 | MP0002933_joint_inflammation | 0.70436230 |
| 110 | MP0009115_abnormal_fat_cell | 0.69825040 |
| 111 | MP0005647_abnormal_sex_gland | 0.67937904 |
| 112 | MP0009765_abnormal_xenobiotic_induced | 0.67582670 |
| 113 | MP0005390_skeleton_phenotype | 0.67300791 |
| 114 | MP0001849_ear_inflammation | 0.63744869 |
| 115 | MP0003279_aneurysm | 0.62552104 |
| 116 | MP0002132_abnormal_respiratory_system | 0.59452019 |
| 117 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.58749965 |
| 118 | MP0003795_abnormal_bone_structure | 0.58463553 |
| 119 | MP0000598_abnormal_liver_morphology | 0.58296314 |
| 120 | MP0005319_abnormal_enzyme/_coenzyme | 0.56744004 |
| 121 | MP0008874_decreased_physiological_sensi | 0.54006538 |
| 122 | MP0003186_abnormal_redox_activity | 0.53706367 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Recurrent abscess formation (HP:0002722) | 6.66940476 |
| 2 | Recurrent bacterial skin infections (HP:0005406) | 6.33879659 |
| 3 | Eczematoid dermatitis (HP:0000976) | 6.02500723 |
| 4 | Recurrent gram-negative bacterial infections (HP:0005420) | 4.66771127 |
| 5 | Elevated erythrocyte sedimentation rate (HP:0003565) | 4.37442222 |
| 6 | Obstructive lung disease (HP:0006536) | 4.23787202 |
| 7 | Chronic obstructive pulmonary disease (HP:0006510) | 4.23787202 |
| 8 | Myositis (HP:0100614) | 4.13884766 |
| 9 | Recurrent skin infections (HP:0001581) | 4.01170970 |
| 10 | Systemic lupus erythematosus (HP:0002725) | 3.95703718 |
| 11 | Loss of speech (HP:0002371) | 3.84029825 |
| 12 | Mediastinal lymphadenopathy (HP:0100721) | 3.80350649 |
| 13 | Papilledema (HP:0001085) | 3.79709703 |
| 14 | Vacuolated lymphocytes (HP:0001922) | 3.72617211 |
| 15 | Thrombocytosis (HP:0001894) | 3.71285204 |
| 16 | Abnormality of glycolipid metabolism (HP:0010969) | 3.67190848 |
| 17 | Abnormality of liposaccharide metabolism (HP:0010968) | 3.67190848 |
| 18 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 3.67190848 |
| 19 | Meningitis (HP:0001287) | 3.65417794 |
| 20 | Abnormality of macrophages (HP:0004311) | 3.64278186 |
| 21 | Cellulitis (HP:0100658) | 3.64113203 |
| 22 | Mutism (HP:0002300) | 3.62604884 |
| 23 | Recurrent fungal infections (HP:0002841) | 3.60977329 |
| 24 | Spontaneous hematomas (HP:0007420) | 3.53851731 |
| 25 | Recurrent viral infections (HP:0004429) | 3.52549847 |
| 26 | Agnosia (HP:0010524) | 3.51174865 |
| 27 | Increased cerebral lipofuscin (HP:0011813) | 3.35406683 |
| 28 | IgM deficiency (HP:0002850) | 3.30902057 |
| 29 | Abnormality of the prostate (HP:0008775) | 3.28502278 |
| 30 | Amyloidosis (HP:0011034) | 3.28197313 |
| 31 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 3.17695750 |
| 32 | Glomerulonephritis (HP:0000099) | 3.12581117 |
| 33 | Disinhibition (HP:0000734) | 3.03849853 |
| 34 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.99222886 |
| 35 | Gingivitis (HP:0000230) | 2.98705905 |
| 36 | Periodontitis (HP:0000704) | 2.93057829 |
| 37 | Joint hemorrhage (HP:0005261) | 2.91075909 |
| 38 | Abnormality of T cell physiology (HP:0011840) | 2.90587732 |
| 39 | Orchitis (HP:0100796) | 2.90201668 |
| 40 | Gastrointestinal infarctions (HP:0005244) | 2.87067864 |
| 41 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.86521042 |
| 42 | Recurrent cutaneous fungal infections (HP:0011370) | 2.86521042 |
| 43 | Osteomyelitis (HP:0002754) | 2.84434188 |
| 44 | Dysostosis multiplex (HP:0000943) | 2.83939498 |
| 45 | J-shaped sella turcica (HP:0002680) | 2.78513856 |
| 46 | Chronic otitis media (HP:0000389) | 2.75134354 |
| 47 | Vasculitis (HP:0002633) | 2.74534230 |
| 48 | Basal ganglia calcification (HP:0002135) | 2.68241862 |
| 49 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 2.68076028 |
| 50 | Increased IgE level (HP:0003212) | 2.63724757 |
| 51 | Purpura (HP:0000979) | 2.61823438 |
| 52 | Neuronal loss in central nervous system (HP:0002529) | 2.58261399 |
| 53 | Upper motor neuron abnormality (HP:0002127) | 2.56535685 |
| 54 | Recurrent pneumonia (HP:0006532) | 2.54164412 |
| 55 | Epistaxis (HP:0000421) | 2.52879186 |
| 56 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 2.51251957 |
| 57 | Petechiae (HP:0000967) | 2.50483711 |
| 58 | Prostate neoplasm (HP:0100787) | 2.47690136 |
| 59 | Autoimmune thrombocytopenia (HP:0001973) | 2.47072753 |
| 60 | Myocardial infarction (HP:0001658) | 2.45270875 |
| 61 | Eosinophilia (HP:0001880) | 2.43049296 |
| 62 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.41255182 |
| 63 | Retrobulbar optic neuritis (HP:0100654) | 2.39291309 |
| 64 | Optic neuritis (HP:0100653) | 2.39291309 |
| 65 | Agammaglobulinemia (HP:0004432) | 2.38352816 |
| 66 | Pustule (HP:0200039) | 2.38259090 |
| 67 | Hepatosplenomegaly (HP:0001433) | 2.37329080 |
| 68 | Inflammation of the large intestine (HP:0002037) | 2.33923561 |
| 69 | Diminished motivation (HP:0000745) | 2.32486206 |
| 70 | Gastrointestinal inflammation (HP:0004386) | 2.32412438 |
| 71 | Pulmonary infiltrates (HP:0002113) | 2.31578816 |
| 72 | Apathy (HP:0000741) | 2.31521578 |
| 73 | Chest pain (HP:0100749) | 2.30634648 |
| 74 | Thoracic kyphosis (HP:0002942) | 2.30330646 |
| 75 | Leukocytosis (HP:0001974) | 2.29888118 |
| 76 | Urticaria (HP:0001025) | 2.29840899 |
| 77 | Prolonged bleeding time (HP:0003010) | 2.29226828 |
| 78 | Abnormal platelet function (HP:0011869) | 2.28683029 |
| 79 | Impaired platelet aggregation (HP:0003540) | 2.28683029 |
| 80 | Hemoptysis (HP:0002105) | 2.27721388 |
| 81 | Amaurosis fugax (HP:0100576) | 2.26524704 |
| 82 | Global brain atrophy (HP:0002283) | 2.24735859 |
| 83 | Granulocytopenia (HP:0001913) | 2.24476825 |
| 84 | Interstitial pulmonary disease (HP:0006530) | 2.23824895 |
| 85 | Mucopolysacchariduria (HP:0008155) | 2.23566256 |
| 86 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.23566256 |
| 87 | Increased serum ferritin (HP:0003281) | 2.22758119 |
| 88 | Axonal loss (HP:0003447) | 2.21752355 |
| 89 | Recurrent lower respiratory tract infections (HP:0002783) | 2.19333750 |
| 90 | Abnormality of the pleura (HP:0002103) | 2.18527793 |
| 91 | Sepsis (HP:0100806) | 2.16133832 |
| 92 | Abnormality of T cells (HP:0002843) | 2.15991275 |
| 93 | Personality changes (HP:0000751) | 2.15808471 |
| 94 | Keratoconjunctivitis sicca (HP:0001097) | 2.15734869 |
| 95 | Abnormality of complement system (HP:0005339) | 2.15161274 |
| 96 | Spondylolisthesis (HP:0003302) | 2.14718184 |
| 97 | Hematochezia (HP:0002573) | 2.13367278 |
| 98 | Cheilitis (HP:0100825) | 2.12389916 |
| 99 | Polygenic inheritance (HP:0010982) | 2.11405722 |
| 100 | Colitis (HP:0002583) | 2.10562127 |
| 101 | Skin ulcer (HP:0200042) | 2.09373283 |
| 102 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.06783584 |
| 103 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.06783584 |
| 104 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.06783584 |
| 105 | Progressive neurologic deterioration (HP:0002344) | 2.05768378 |
| 106 | Restrictive lung disease (HP:0002091) | 2.04693564 |
| 107 | Abnormality of the thoracic spine (HP:0100711) | 2.03890197 |
| 108 | Polyneuropathy (HP:0001271) | 2.03477204 |
| 109 | Arterial thrombosis (HP:0004420) | 1.99855675 |
| 110 | Inappropriate behavior (HP:0000719) | 1.98426193 |
| 111 | Stomatitis (HP:0010280) | 1.97850956 |
| 112 | Pulmonary fibrosis (HP:0002206) | 1.97686944 |
| 113 | Panhypogammaglobulinemia (HP:0003139) | 1.97648810 |
| 114 | Malnutrition (HP:0004395) | 1.96854434 |
| 115 | Chromsome breakage (HP:0040012) | 1.96007686 |
| 116 | Complement deficiency (HP:0004431) | 1.95821262 |
| 117 | Hypertensive crisis (HP:0100735) | 1.95396932 |
| 118 | Recurrent bronchitis (HP:0002837) | 1.94386110 |
| 119 | Abnormality of the lumbar spine (HP:0100712) | 1.93897464 |
| 120 | Acrocyanosis (HP:0001063) | 1.93602976 |
| 121 | Keratoconjunctivitis (HP:0001096) | 1.93107436 |
| 122 | B lymphocytopenia (HP:0010976) | 1.91575709 |
| 123 | Abnormality of B cell number (HP:0010975) | 1.91575709 |
| 124 | Skin rash (HP:0000988) | 1.91077252 |
| 125 | Lymphopenia (HP:0001888) | 1.90730600 |
| 126 | T lymphocytopenia (HP:0005403) | 1.89781217 |
| 127 | Nephritis (HP:0000123) | 1.89558421 |
| 128 | Thin bony cortex (HP:0002753) | 1.88654988 |
| 129 | Encephalitis (HP:0002383) | 1.88172432 |
| 130 | Abnormality of the periventricular white matter (HP:0002518) | 1.86517670 |
| 131 | Pulmonary embolism (HP:0002204) | 1.86031337 |
| 132 | Esophageal varix (HP:0002040) | 1.85610628 |
| 133 | Peripheral demyelination (HP:0011096) | 1.84652297 |
| 134 | Memory impairment (HP:0002354) | 1.84099926 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BLK | 3.70666081 |
| 2 | IRAK4 | 3.54963413 |
| 3 | PRPF4B | 3.12849858 |
| 4 | MAP4K1 | 3.12334933 |
| 5 | RIPK4 | 2.82230105 |
| 6 | CLK1 | 2.74797471 |
| 7 | TAOK3 | 2.48199865 |
| 8 | KIT | 2.42818241 |
| 9 | TYK2 | 2.33144210 |
| 10 | STK10 | 2.30546444 |
| 11 | CSF1R | 2.29919858 |
| 12 | MAP3K14 | 2.22540341 |
| 13 | TEC | 2.16338527 |
| 14 | TGFBR2 | 2.12735770 |
| 15 | ERN1 | 2.12681639 |
| 16 | IRAK3 | 2.01914286 |
| 17 | BTK | 1.93863064 |
| 18 | TBK1 | 1.91227982 |
| 19 | EEF2K | 1.90128291 |
| 20 | FGR | 1.87377840 |
| 21 | PIM2 | 1.86617360 |
| 22 | FES | 1.83857625 |
| 23 | NEK9 | 1.72792097 |
| 24 | MAP3K10 | 1.67044152 |
| 25 | SYK | 1.66825216 |
| 26 | CDC42BPA | 1.60315458 |
| 27 | MAP2K3 | 1.60297361 |
| 28 | ZAP70 | 1.58106490 |
| 29 | FLT3 | 1.48674030 |
| 30 | EIF2AK1 | 1.44576140 |
| 31 | TXK | 1.41140206 |
| 32 | LYN | 1.29530694 |
| 33 | DDR2 | 1.29048775 |
| 34 | IKBKB | 1.29037522 |
| 35 | MAP3K11 | 1.27425116 |
| 36 | PIM1 | 1.20425374 |
| 37 | CSK | 1.19545429 |
| 38 | MATK | 1.19170228 |
| 39 | ITK | 1.17289118 |
| 40 | PKN2 | 1.17205358 |
| 41 | IKBKE | 1.15803615 |
| 42 | MAP3K1 | 1.14233384 |
| 43 | STK4 | 1.12498604 |
| 44 | HCK | 1.12479999 |
| 45 | SCYL2 | 1.12333092 |
| 46 | BRSK2 | 1.11177418 |
| 47 | GRK7 | 1.09063954 |
| 48 | JAK3 | 1.05056839 |
| 49 | JAK1 | 1.04349240 |
| 50 | SMG1 | 0.98544594 |
| 51 | LRRK2 | 0.97956786 |
| 52 | TAOK2 | 0.97500352 |
| 53 | TNK2 | 0.97417624 |
| 54 | CDC7 | 0.96939034 |
| 55 | LCK | 0.95460852 |
| 56 | RPS6KA6 | 0.94889119 |
| 57 | MAP3K13 | 0.94153350 |
| 58 | TTN | 0.93767704 |
| 59 | RPS6KC1 | 0.90698513 |
| 60 | RPS6KL1 | 0.90698513 |
| 61 | MAP3K8 | 0.90320118 |
| 62 | GRK6 | 0.89762214 |
| 63 | CAMK1D | 0.89442719 |
| 64 | RPS6KA4 | 0.88313941 |
| 65 | TAOK1 | 0.86805059 |
| 66 | SIK3 | 0.86280295 |
| 67 | JAK2 | 0.85112087 |
| 68 | EPHB1 | 0.82178049 |
| 69 | VRK1 | 0.81798482 |
| 70 | MAPK4 | 0.79328158 |
| 71 | ATR | 0.79122100 |
| 72 | EIF2AK3 | 0.77495165 |
| 73 | NEK2 | 0.77025135 |
| 74 | STK16 | 0.76887475 |
| 75 | PAK4 | 0.76553427 |
| 76 | BMPR2 | 0.76170040 |
| 77 | PDPK1 | 0.75630315 |
| 78 | MAP3K3 | 0.75063477 |
| 79 | CDK6 | 0.74296645 |
| 80 | CDK12 | 0.73117176 |
| 81 | CDK4 | 0.72597618 |
| 82 | TRPM7 | 0.71623316 |
| 83 | MAP3K6 | 0.70358968 |
| 84 | MOS | 0.67324576 |
| 85 | TSSK6 | 0.66627936 |
| 86 | MARK3 | 0.65333295 |
| 87 | RPS6KA2 | 0.65175951 |
| 88 | WEE1 | 0.65163617 |
| 89 | CHUK | 0.64912753 |
| 90 | SIK2 | 0.63963943 |
| 91 | EIF2AK2 | 0.63692144 |
| 92 | MAPKAPK2 | 0.60268230 |
| 93 | ACVR1B | 0.59871289 |
| 94 | RIPK1 | 0.56903706 |
| 95 | BUB1 | 0.55092202 |
| 96 | YES1 | 0.54545789 |
| 97 | PRKCQ | 0.53510172 |
| 98 | IRAK2 | 0.52453841 |
| 99 | TTK | 0.51682933 |
| 100 | PRKCD | 0.51010395 |
| 101 | NME2 | 0.50228428 |
| 102 | PRKD2 | 0.48663807 |
| 103 | PDK1 | 0.48253703 |
| 104 | MARK2 | 0.47038707 |
| 105 | ABL1 | 0.45219080 |
| 106 | PIK3CG | 0.43365589 |
| 107 | TRIB3 | 0.42214656 |
| 108 | MAPK7 | 0.40953611 |
| 109 | ABL2 | 0.40664309 |
| 110 | FYN | 0.40439794 |
| 111 | KSR2 | 0.39810947 |
| 112 | HIPK2 | 0.39717499 |
| 113 | CCNB1 | 0.39709996 |
| 114 | MAPK11 | 0.37895282 |
| 115 | CDK8 | 0.37681468 |
| 116 | DAPK2 | 0.36396094 |
| 117 | RPS6KB2 | 0.36188179 |
| 118 | MAP3K5 | 0.36030599 |
| 119 | BRSK1 | 0.35712784 |
| 120 | CAMKK1 | 0.35031873 |
| 121 | ZAK | 0.34432552 |
| 122 | IRAK1 | 0.34197348 |
| 123 | CAMK1G | 0.33611088 |
| 124 | TGFBR1 | 0.31890711 |
| 125 | CDK19 | 0.30298774 |
| 126 | EGFR | 0.30163612 |
| 127 | TESK2 | 0.29667020 |
| 128 | PDK2 | 0.28722852 |
| 129 | FGFR3 | 0.28307403 |
| 130 | CAMKK2 | 0.27583622 |
| 131 | MAPK12 | 0.27552107 |
| 132 | CDK7 | 0.27383530 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Leishmaniasis_Homo sapiens_hsa05140 | 3.14822907 |
| 2 | Other glycan degradation_Homo sapiens_hsa00511 | 3.02440992 |
| 3 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.96992181 |
| 4 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 2.89954412 |
| 5 | DNA replication_Homo sapiens_hsa03030 | 2.86508201 |
| 6 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.80224802 |
| 7 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.43716069 |
| 8 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.38150816 |
| 9 | Lysosome_Homo sapiens_hsa04142 | 2.29453282 |
| 10 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.15888046 |
| 11 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.14287371 |
| 12 | Pertussis_Homo sapiens_hsa05133 | 2.05729439 |
| 13 | Tuberculosis_Homo sapiens_hsa05152 | 2.00383532 |
| 14 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 2.00359258 |
| 15 | Legionellosis_Homo sapiens_hsa05134 | 1.95516384 |
| 16 | Mismatch repair_Homo sapiens_hsa03430 | 1.90120602 |
| 17 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.87852601 |
| 18 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.87805876 |
| 19 | Base excision repair_Homo sapiens_hsa03410 | 1.79607086 |
| 20 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.78689874 |
| 21 | Measles_Homo sapiens_hsa05162 | 1.74991823 |
| 22 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.74800798 |
| 23 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.69397389 |
| 24 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.63962146 |
| 25 | Homologous recombination_Homo sapiens_hsa03440 | 1.63231879 |
| 26 | Phagosome_Homo sapiens_hsa04145 | 1.61308618 |
| 27 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.58143178 |
| 28 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.57773238 |
| 29 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.53263308 |
| 30 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.52026883 |
| 31 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.47629324 |
| 32 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.46701533 |
| 33 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.43059469 |
| 34 | Influenza A_Homo sapiens_hsa05164 | 1.42909413 |
| 35 | Apoptosis_Homo sapiens_hsa04210 | 1.41313212 |
| 36 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.39289715 |
| 37 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.30126054 |
| 38 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.28862163 |
| 39 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.26892925 |
| 40 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.26777920 |
| 41 | Shigellosis_Homo sapiens_hsa05131 | 1.24605725 |
| 42 | Salmonella infection_Homo sapiens_hsa05132 | 1.23187581 |
| 43 | Malaria_Homo sapiens_hsa05144 | 1.22720956 |
| 44 | Hepatitis B_Homo sapiens_hsa05161 | 1.18387736 |
| 45 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.17613841 |
| 46 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.10663853 |
| 47 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.07281549 |
| 48 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.02934515 |
| 49 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.97943798 |
| 50 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.97365473 |
| 51 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.96714620 |
| 52 | Platelet activation_Homo sapiens_hsa04611 | 0.96224106 |
| 53 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.94701250 |
| 54 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.94456708 |
| 55 | Asthma_Homo sapiens_hsa05310 | 0.92447049 |
| 56 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.90170854 |
| 57 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.89206189 |
| 58 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.87281609 |
| 59 | Cell cycle_Homo sapiens_hsa04110 | 0.87043291 |
| 60 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.85698706 |
| 61 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.84632387 |
| 62 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.83299668 |
| 63 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.82153654 |
| 64 | Viral myocarditis_Homo sapiens_hsa05416 | 0.81964821 |
| 65 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.76842418 |
| 66 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.73609211 |
| 67 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.73240420 |
| 68 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.71728538 |
| 69 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.70804814 |
| 70 | Spliceosome_Homo sapiens_hsa03040 | 0.69960251 |
| 71 | Prion diseases_Homo sapiens_hsa05020 | 0.68244431 |
| 72 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.67514667 |
| 73 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.67268499 |
| 74 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.67113542 |
| 75 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.64276616 |
| 76 | Hepatitis C_Homo sapiens_hsa05160 | 0.64122381 |
| 77 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.63066884 |
| 78 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.62281091 |
| 79 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.62194704 |
| 80 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.61843928 |
| 81 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.60982516 |
| 82 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.60889276 |
| 83 | Ribosome_Homo sapiens_hsa03010 | 0.58956875 |
| 84 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.57435190 |
| 85 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.57260369 |
| 86 | Bladder cancer_Homo sapiens_hsa05219 | 0.56375811 |
| 87 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.56286807 |
| 88 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.55756548 |
| 89 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.53973960 |
| 90 | Allograft rejection_Homo sapiens_hsa05330 | 0.53908958 |
| 91 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.52444739 |
| 92 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.51004177 |
| 93 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.50936453 |
| 94 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.49548625 |
| 95 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.48883345 |
| 96 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.44950873 |
| 97 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.44639554 |
| 98 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.44113329 |
| 99 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.43828257 |
| 100 | HTLV-I infection_Homo sapiens_hsa05166 | 0.43619695 |
| 101 | Galactose metabolism_Homo sapiens_hsa00052 | 0.41202958 |
| 102 | Protein export_Homo sapiens_hsa03060 | 0.40499288 |
| 103 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.40032323 |
| 104 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.39916578 |
| 105 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.37676321 |
| 106 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.36511230 |
| 107 | Endocytosis_Homo sapiens_hsa04144 | 0.35407588 |
| 108 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.33881498 |
| 109 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.33875080 |
| 110 | Amoebiasis_Homo sapiens_hsa05146 | 0.33582214 |
| 111 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.32840242 |
| 112 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.32314602 |
| 113 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.31487741 |
| 114 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.29755198 |
| 115 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.29704263 |
| 116 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.28459973 |
| 117 | ABC transporters_Homo sapiens_hsa02010 | 0.28189110 |
| 118 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.26320189 |
| 119 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.25021875 |
| 120 | Insulin resistance_Homo sapiens_hsa04931 | 0.24707570 |
| 121 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.24647956 |
| 122 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.24588477 |
| 123 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.23715336 |
| 124 | Mineral absorption_Homo sapiens_hsa04978 | 0.22801545 |
| 125 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.18500293 |

