TIGAR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)6.15640857
2ribosome assembly (GO:0042255)5.66474816
3nucleobase biosynthetic process (GO:0046112)5.58830830
4mitotic metaphase plate congression (GO:0007080)5.40023809
5ribosome biogenesis (GO:0042254)4.77437211
6rRNA modification (GO:0000154)4.55829882
7folic acid metabolic process (GO:0046655)4.38577619
8proteasome assembly (GO:0043248)4.32020986
9DNA replication checkpoint (GO:0000076)4.30285323
10regulation of spindle organization (GO:0090224)4.24668032
11metaphase plate congression (GO:0051310)4.12775212
12DNA double-strand break processing (GO:0000729)4.05617720
13cullin deneddylation (GO:0010388)4.01052306
14formation of translation preinitiation complex (GO:0001731)4.00111446
15regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.93793121
16DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.90076434
17protein deneddylation (GO:0000338)3.87849685
18protein localization to kinetochore (GO:0034501)3.87468199
19signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.85751698
20signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.85751698
21signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.85751698
22anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.83131570
23termination of RNA polymerase III transcription (GO:0006386)3.82495160
24transcription elongation from RNA polymerase III promoter (GO:0006385)3.82495160
25signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.81348031
26intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.81348031
27respiratory chain complex IV assembly (GO:0008535)3.77964963
28regulation of translation in response to stress (GO:0043555)3.76475003
29regulation of translational termination (GO:0006449)3.74112471
30positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.70610610
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.68532744
32histone mRNA metabolic process (GO:0008334)3.68155671
33pseudouridine synthesis (GO:0001522)3.67980287
34regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.66191031
35chromatin remodeling at centromere (GO:0031055)3.65582533
36transcription from RNA polymerase I promoter (GO:0006360)3.64308928
37positive regulation of chromosome segregation (GO:0051984)3.62545197
38signal transduction involved in cell cycle checkpoint (GO:0072395)3.61012418
39transcription elongation from RNA polymerase I promoter (GO:0006362)3.56553469
40termination of RNA polymerase I transcription (GO:0006363)3.54936478
41regulation of mitotic spindle organization (GO:0060236)3.54884043
42exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.54625500
43regulation of mitochondrial translation (GO:0070129)3.54057302
44IMP biosynthetic process (GO:0006188)3.53261191
45chaperone-mediated protein transport (GO:0072321)3.53245472
46protein K6-linked ubiquitination (GO:0085020)3.52546846
47RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.51613981
48tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.51613981
49establishment of protein localization to mitochondrial membrane (GO:0090151)3.51208919
50negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.51118607
51mitotic nuclear envelope disassembly (GO:0007077)3.49541110
527-methylguanosine mRNA capping (GO:0006370)3.49469686
53ribonucleoprotein complex biogenesis (GO:0022613)3.48829255
54positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.48120877
55DNA deamination (GO:0045006)3.47293811
56folic acid transport (GO:0015884)3.47080812
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.46844972
58negative regulation of DNA-dependent DNA replication (GO:2000104)3.44807123
59NADH metabolic process (GO:0006734)3.44643195
60amino acid salvage (GO:0043102)3.43141487
61L-methionine salvage (GO:0071267)3.43141487
62L-methionine biosynthetic process (GO:0071265)3.43141487
63DNA catabolic process, exonucleolytic (GO:0000738)3.42603869
64establishment of chromosome localization (GO:0051303)3.42442764
65histone exchange (GO:0043486)3.40744977
66mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.39219615
67activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.39150405
68maturation of 5.8S rRNA (GO:0000460)3.39113227
697-methylguanosine RNA capping (GO:0009452)3.37250476
70RNA capping (GO:0036260)3.37250476
71rRNA methylation (GO:0031167)3.35769645
72spindle checkpoint (GO:0031577)3.35555708
73maturation of SSU-rRNA (GO:0030490)3.34411849
74protein localization to chromosome, centromeric region (GO:0071459)3.32581044
75blastocyst development (GO:0001824)3.32279870
76rRNA processing (GO:0006364)3.30019472
77protein neddylation (GO:0045116)3.29792910
78transcription initiation from RNA polymerase I promoter (GO:0006361)3.29739688
79protein-cofactor linkage (GO:0018065)3.29491903
80nuclear envelope disassembly (GO:0051081)3.28116844
81membrane disassembly (GO:0030397)3.28116844
82spliceosomal snRNP assembly (GO:0000387)3.24118748
83DNA replication initiation (GO:0006270)3.23898966
84DNA replication-dependent nucleosome assembly (GO:0006335)3.21738267
85DNA replication-dependent nucleosome organization (GO:0034723)3.21738267
86peptidyl-histidine modification (GO:0018202)3.21112507
87positive regulation of ligase activity (GO:0051351)3.21082680
88rRNA metabolic process (GO:0016072)3.20935261
89mitotic spindle checkpoint (GO:0071174)3.19563572
90protein targeting to mitochondrion (GO:0006626)3.18892816
91platelet dense granule organization (GO:0060155)3.18723808
92negative regulation of chromosome segregation (GO:0051985)3.18532618
93IMP metabolic process (GO:0046040)3.17719421
94mitotic sister chromatid segregation (GO:0000070)3.17294959
95somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.16405117
96isotype switching (GO:0045190)3.16405117
97somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.16405117
98response to X-ray (GO:0010165)3.16071384
99regulation of chromosome segregation (GO:0051983)3.15715611
100negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.14810111
101negative regulation of ligase activity (GO:0051352)3.14810111
102regulation of G0 to G1 transition (GO:0070316)3.11421213
103negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.11014018
104negative regulation of sister chromatid segregation (GO:0033046)3.11014018
105negative regulation of mitotic sister chromatid separation (GO:2000816)3.11014018
106negative regulation of mitotic sister chromatid segregation (GO:0033048)3.11014018
107regulation of mitotic spindle checkpoint (GO:1903504)3.10266246
108regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.10266246
109mitotic spindle assembly checkpoint (GO:0007094)3.09990989
110regulation of ubiquitin-protein transferase activity (GO:0051438)3.09907845
111mitochondrial DNA replication (GO:0006264)3.09904048
112attachment of spindle microtubules to kinetochore (GO:0008608)3.09879075
113cytochrome complex assembly (GO:0017004)3.09805119
114negative regulation of translational initiation (GO:0045947)3.09151010
115regulation of mitotic metaphase/anaphase transition (GO:0030071)3.06644029
116DNA damage response, detection of DNA damage (GO:0042769)3.06549049
117protein localization to mitochondrion (GO:0070585)3.05962577
118skeletal muscle tissue regeneration (GO:0043403)3.04873705
119mitochondrial RNA metabolic process (GO:0000959)3.04241087
120spindle assembly checkpoint (GO:0071173)3.03888566
121antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.02952705
122negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02677965
123establishment of protein localization to mitochondrion (GO:0072655)3.01502344
124protein complex biogenesis (GO:0070271)3.01274554
125regulation of double-strand break repair via homologous recombination (GO:0010569)3.01226736
126regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.00301852
127mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.00266697
128mitochondrial respiratory chain complex I assembly (GO:0032981)3.00266697
129NADH dehydrogenase complex assembly (GO:0010257)3.00266697
130mitochondrial respiratory chain complex assembly (GO:0033108)2.99802595
131L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.98222347
132negative regulation of protein ubiquitination (GO:0031397)2.97735592
133regulation of cellular amino acid metabolic process (GO:0006521)2.97521833
134positive regulation of cell cycle arrest (GO:0071158)2.95416550
135mitotic G1 DNA damage checkpoint (GO:0031571)2.95319533
136cell cycle G1/S phase transition (GO:0044843)2.95270683
137G1/S transition of mitotic cell cycle (GO:0000082)2.95270683
138regulation of centrosome cycle (GO:0046605)2.95035786
139methionine biosynthetic process (GO:0009086)2.94216376
140nuclear pore organization (GO:0006999)2.94097010
141kinetochore assembly (GO:0051382)2.93529406
142CENP-A containing nucleosome assembly (GO:0034080)2.92503628
143postreplication repair (GO:0006301)2.91121433
144histone-serine phosphorylation (GO:0035404)2.91073387
145nuclear envelope organization (GO:0006998)2.90273471
146signal transduction involved in DNA integrity checkpoint (GO:0072401)2.90098837
147signal transduction involved in DNA damage checkpoint (GO:0072422)2.90098837
148DNA-templated transcription, elongation (GO:0006354)2.89615504
149regulation of centriole replication (GO:0046599)2.89055144
150lung-associated mesenchyme development (GO:0060484)2.88838915
151tRNA processing (GO:0008033)2.88776608
152regulation of ligase activity (GO:0051340)2.88753387
153DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.87867890
154regulation of cellular amine metabolic process (GO:0033238)2.87716431
155antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.87123062
156regulation of nuclear cell cycle DNA replication (GO:0033262)2.87060394
157tRNA methylation (GO:0030488)2.85001789
158tRNA metabolic process (GO:0006399)2.84703441
159transcription from mitochondrial promoter (GO:0006390)2.83932194
160DNA-dependent DNA replication (GO:0006261)2.82898265

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.43245070
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.65950602
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.92208570
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.64108541
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.48991071
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.42506027
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.35430996
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.24374665
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.08170862
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.03760220
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.98229408
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.97887752
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.86235215
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.79485674
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77944772
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.76063101
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.55330781
18NANOG_18555785_ChIP-Seq_MESCs_Mouse2.47875996
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.42949134
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27507922
21ZNF274_21170338_ChIP-Seq_K562_Hela2.27493125
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.23757896
23VDR_23849224_ChIP-Seq_CD4+_Human2.20950402
24POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.14312388
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14024555
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.09497008
27XRN2_22483619_ChIP-Seq_HELA_Human2.08043682
28ZNF263_19887448_ChIP-Seq_K562_Human2.06833012
29YY1_21170310_ChIP-Seq_MESCs_Mouse2.06437045
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.01703100
31AR_21909140_ChIP-Seq_LNCAP_Human2.00546989
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.98770888
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.97811144
34GABP_19822575_ChIP-Seq_HepG2_Human1.95646948
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95388994
36VDR_22108803_ChIP-Seq_LS180_Human1.92871343
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91025130
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.89042358
39SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.87776639
40DCP1A_22483619_ChIP-Seq_HELA_Human1.87328293
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.86943722
42EWS_26573619_Chip-Seq_HEK293_Human1.81588306
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81147627
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78867265
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76790939
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.76403440
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71945636
48NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.70994666
49FOXP3_21729870_ChIP-Seq_TREG_Human1.67652543
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67601333
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66172070
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58456418
53KDM5A_27292631_Chip-Seq_BREAST_Human1.56713468
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.53627517
55TTF2_22483619_ChIP-Seq_HELA_Human1.52720315
56FUS_26573619_Chip-Seq_HEK293_Human1.50673483
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.50664884
58MYC_18940864_ChIP-ChIP_HL60_Human1.50422370
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.48277686
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47700570
61NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.46727984
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45774721
63BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.44865026
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.40668269
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.40668269
66KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.40668269
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.38339103
68CIITA_25753668_ChIP-Seq_RAJI_Human1.38177558
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35519563
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32687819
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30944322
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30421341
73SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27687043
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27587157
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27387796
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27239298
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.26708467
78P300_19829295_ChIP-Seq_ESCs_Human1.24433340
79NANOG_21062744_ChIP-ChIP_HESCs_Human1.23492912
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22429789
81NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.21941435
82TAF15_26573619_Chip-Seq_HEK293_Human1.20527508
83TCF3_18692474_ChIP-Seq_MEFs_Mouse1.17938123
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.16945212
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16710552
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.14990558
87ELK1_19687146_ChIP-ChIP_HELA_Human1.14763922
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.11473196
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10455668
90SOX2_18692474_ChIP-Seq_MEFs_Mouse1.10282177
91OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08956484
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08377422
93ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07373030
94ELK1_22589737_ChIP-Seq_MCF10A_Human1.06972617
95CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06219522
96PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05615440
97SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03894021
98POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.03602725
99IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03568697
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03108201
101CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01264385
102HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00422530
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00228483
104NANOG_16153702_ChIP-ChIP_HESCs_Human0.99289745
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99155202
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98826617
107POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98697352
108NANOG_18692474_ChIP-Seq_MEFs_Mouse0.97800494
109TFEB_21752829_ChIP-Seq_HELA_Human0.97796828
110SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96972353
111TCF3_18692474_ChIP-Seq_MESCs_Mouse0.96123856
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96109010
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94000715
114IRF8_21731497_ChIP-ChIP_J774_Mouse0.93964755
115SOX2_18692474_ChIP-Seq_MESCs_Mouse0.92816635
116SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92800489
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92583616
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91849524
119CBP_20019798_ChIP-Seq_JUKART_Human0.90830897
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90830897
121KAP1_27257070_Chip-Seq_ESCs_Mouse0.89833271
122NANOG_19829295_ChIP-Seq_ESCs_Human0.89419625
123SOX2_19829295_ChIP-Seq_ESCs_Human0.89419625
124TP53_22573176_ChIP-Seq_HFKS_Human0.89268287
125E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89172953
126CRX_20693478_ChIP-Seq_RETINA_Mouse0.89115430
127KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88704751
128ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88639839
129IRF1_19129219_ChIP-ChIP_H3396_Human0.87716988
130CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86136012
131SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.85927125
132MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85723056
133SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85578672
134SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85110939
135ELF5_23300383_ChIP-Seq_T47D_Human0.84858701
136HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84003329
137CDX2_22108803_ChIP-Seq_LS180_Human0.83254583
138TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.82957591
139NANOG_18692474_ChIP-Seq_MESCs_Mouse0.82731079
140NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.81578048
141FOXA1_27270436_Chip-Seq_PROSTATE_Human0.81254944
142FOXA1_25329375_ChIP-Seq_VCAP_Human0.81254944
143SALL4_22934838_ChIP-ChIP_CD34+_Human0.81214316
144NOTCH1_21737748_ChIP-Seq_TLL_Human0.80646330
145AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80617174

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.67044520
2MP0003111_abnormal_nucleus_morphology4.45373066
3MP0003646_muscle_fatigue4.42719423
4MP0004957_abnormal_blastocyst_morpholog4.08555106
5MP0003718_maternal_effect3.41357308
6MP0010094_abnormal_chromosome_stability3.39778728
7MP0003077_abnormal_cell_cycle3.28258223
8MP0004084_abnormal_cardiac_muscle3.08087409
9MP0002102_abnormal_ear_morphology2.83957785
10MP0008057_abnormal_DNA_replication2.65991518
11MP0003186_abnormal_redox_activity2.58802655
12MP0000372_irregular_coat_pigmentation2.48991666
13MP0000750_abnormal_muscle_regeneration2.48101512
14MP0008058_abnormal_DNA_repair2.47632591
15MP0001730_embryonic_growth_arrest2.41276673
16MP0008260_abnormal_autophagy2.30747894
17MP0006054_spinal_hemorrhage2.28978122
18MP0003221_abnormal_cardiomyocyte_apopto2.28147299
19MP0003123_paternal_imprinting2.26264987
20MP0008932_abnormal_embryonic_tissue2.25267227
21MP0002269_muscular_atrophy2.24571955
22MP0004036_abnormal_muscle_relaxation2.13146143
23MP0004145_abnormal_muscle_electrophysio2.10848139
24MP0003195_calcinosis2.09474036
25MP0002837_dystrophic_cardiac_calcinosis2.07528633
26MP0003890_abnormal_embryonic-extraembry2.05739530
27MP0003806_abnormal_nucleotide_metabolis2.04094508
28MP0003786_premature_aging2.00560456
29MP0005330_cardiomyopathy1.94856443
30MP0000747_muscle_weakness1.93388299
31MP0008877_abnormal_DNA_methylation1.92965993
32MP0009697_abnormal_copulation1.91463619
33MP0006072_abnormal_retinal_apoptosis1.90478944
34MP0005380_embryogenesis_phenotype1.88090589
35MP0001672_abnormal_embryogenesis/_devel1.88090589
36MP0000751_myopathy1.87906621
37MP0004215_abnormal_myocardial_fiber1.81652038
38MP0000749_muscle_degeneration1.80208389
39MP0000350_abnormal_cell_proliferation1.78722701
40MP0005367_renal/urinary_system_phenotyp1.76255643
41MP0000516_abnormal_urinary_system1.76255643
42MP0000569_abnormal_digit_pigmentation1.72990670
43MP0006036_abnormal_mitochondrial_physio1.72030904
44MP0009840_abnormal_foam_cell1.71864763
45MP0005075_abnormal_melanosome_morpholog1.69907462
46MP0008007_abnormal_cellular_replicative1.69414584
47MP0003984_embryonic_growth_retardation1.67715013
48MP0006035_abnormal_mitochondrial_morpho1.67278574
49MP0002106_abnormal_muscle_physiology1.64802257
50MP0002088_abnormal_embryonic_growth/wei1.63725003
51MP0000015_abnormal_ear_pigmentation1.62820637
52MP0008789_abnormal_olfactory_epithelium1.60579625
53MP0005408_hypopigmentation1.56846792
54MP0001697_abnormal_embryo_size1.55684052
55MP0005410_abnormal_fertilization1.54487251
56MP0002736_abnormal_nociception_after1.54322372
57MP0003941_abnormal_skin_development1.52273734
58MP0002080_prenatal_lethality1.50583465
59MP0002163_abnormal_gland_morphology1.50531392
60MP0010307_abnormal_tumor_latency1.50099257
61MP0003567_abnormal_fetal_cardiomyocyte1.48459297
62MP0001764_abnormal_homeostasis1.47595717
63MP0004087_abnormal_muscle_fiber1.43566657
64MP0005253_abnormal_eye_physiology1.41644010
65MP0001853_heart_inflammation1.37502908
66MP0000647_abnormal_sebaceous_gland1.34672356
67MP0005084_abnormal_gallbladder_morpholo1.34643293
68MP0002085_abnormal_embryonic_tissue1.33605393
69MP0002090_abnormal_vision1.30295938
70MP0005395_other_phenotype1.23801375
71MP0005369_muscle_phenotype1.23648825
72MP0002084_abnormal_developmental_patter1.22454595
73MP0002086_abnormal_extraembryonic_tissu1.21028783
74MP0001293_anophthalmia1.20505627
75MP0000358_abnormal_cell_content/1.20020174
76MP0002095_abnormal_skin_pigmentation1.19877379
77MP0005174_abnormal_tail_pigmentation1.18222836
78MP0002148_abnormal_hypersensitivity_rea1.17401788
79MP0004233_abnormal_muscle_weight1.17232540
80MP0000759_abnormal_skeletal_muscle1.16528323
81MP0002332_abnormal_exercise_endurance1.15871026
82MP0005620_abnormal_muscle_contractility1.13025543
83MP0001661_extended_life_span1.12715146
84MP0002210_abnormal_sex_determination1.12352942
85MP0002653_abnormal_ependyma_morphology1.11895290
86MP0000427_abnormal_hair_cycle1.10970700
87MP0005451_abnormal_body_composition1.10197506
88MP0006082_CNS_inflammation1.09930590
89MP0005266_abnormal_metabolism1.08926872
90MP0003315_abnormal_perineum_morphology1.08746766
91MP0009785_altered_susceptibility_to1.08281258
92MP0002127_abnormal_cardiovascular_syste1.08007569
93MP0001324_abnormal_eye_pigmentation1.07315137
94MP0001529_abnormal_vocalization1.06228397
95MP0006138_congestive_heart_failure1.03661410
96MP0010352_gastrointestinal_tract_polyps1.03068808
97MP0003137_abnormal_impulse_conducting1.02476332
98MP0001544_abnormal_cardiovascular_syste1.01795431
99MP0005385_cardiovascular_system_phenoty1.01795431
100MP0000371_diluted_coat_color1.01676286
101MP0009672_abnormal_birth_weight1.01172004
102MP0002233_abnormal_nose_morphology1.00375488
103MP0000313_abnormal_cell_death0.99364688
104MP0002234_abnormal_pharynx_morphology0.99037933
105MP0001145_abnormal_male_reproductive0.97637500
106MP0001929_abnormal_gametogenesis0.95724810
107MP0004197_abnormal_fetal_growth/weight/0.94346912
108MP0002938_white_spotting0.94171664
109MP0001188_hyperpigmentation0.93531131
110MP0005671_abnormal_response_to0.93271141
111MP0010630_abnormal_cardiac_muscle0.92603554
112MP0004130_abnormal_muscle_cell0.92543133
113MP0005670_abnormal_white_adipose0.92523205
114MP0004185_abnormal_adipocyte_glucose0.92135211
115MP0003937_abnormal_limbs/digits/tail_de0.91547901
116MP0005379_endocrine/exocrine_gland_phen0.90865608
117MP0003448_altered_tumor_morphology0.88567716
118MP0005499_abnormal_olfactory_system0.87057548
119MP0005394_taste/olfaction_phenotype0.87057548
120MP0005389_reproductive_system_phenotype0.85472159
121MP0004484_altered_response_of0.85317206
122MP0002972_abnormal_cardiac_muscle0.85223095
123MP0005551_abnormal_eye_electrophysiolog0.84079903
124MP0003828_pulmonary_edema0.83612748
125MP0005384_cellular_phenotype0.83165654
126MP0002160_abnormal_reproductive_system0.82767610
127MP0000653_abnormal_sex_gland0.82364380
128MP0009764_decreased_sensitivity_to0.82362456
129MP0003119_abnormal_digestive_system0.81272543
130MP0005076_abnormal_cell_differentiation0.79745408
131MP0005621_abnormal_cell_physiology0.79442333
132MP0006292_abnormal_olfactory_placode0.79186338
133MP0005377_hearing/vestibular/ear_phenot0.78246087
134MP0003878_abnormal_ear_physiology0.78246087
135MP0002177_abnormal_outer_ear0.77413704
136MP0002254_reproductive_system_inflammat0.76196912
137MP0001919_abnormal_reproductive_system0.76182223
138MP0001727_abnormal_embryo_implantation0.74567869
139MP0005666_abnormal_adipose_tissue0.74083127
140MP0002751_abnormal_autonomic_nervous0.73811512
141MP0003950_abnormal_plasma_membrane0.73568912
142MP0005332_abnormal_amino_acid0.72256796
143MP0002006_tumorigenesis0.71644613
144MP0002277_abnormal_respiratory_mucosa0.71271540
145MP0002019_abnormal_tumor_incidence0.70625787
146MP0009333_abnormal_splenocyte_physiolog0.70298655
147MP0000685_abnormal_immune_system0.70077395
148MP0003755_abnormal_palate_morphology0.70065851
149MP0000733_abnormal_muscle_development0.69799068
150MP0004142_abnormal_muscle_tone0.69402585
151MP0001542_abnormal_bone_strength0.69363585
152MP0001191_abnormal_skin_condition0.68611424
153MP0001119_abnormal_female_reproductive0.68529803
154MP0005197_abnormal_uvea_morphology0.68446266
155MP0003011_delayed_dark_adaptation0.68273231
156MP0008775_abnormal_heart_ventricle0.68050980
157MP0003705_abnormal_hypodermis_morpholog0.66547536
158MP0003699_abnormal_female_reproductive0.66163207
159MP0009703_decreased_birth_body0.64409063
160MP0000428_abnormal_craniofacial_morphol0.60217296
161MP0002396_abnormal_hematopoietic_system0.58642803
162MP0000627_abnormal_mammary_gland0.55960584

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)4.83024354
2Birth length less than 3rd percentile (HP:0003561)4.71069005
3Carpal bone hypoplasia (HP:0001498)4.41355794
4Muscle fiber splitting (HP:0003555)4.38896376
5Cerebral hypomyelination (HP:0006808)4.33868538
6Areflexia of lower limbs (HP:0002522)4.02195284
7Acute necrotizing encephalopathy (HP:0006965)4.00118209
8Bundle branch block (HP:0011710)3.86007979
9Hyperglycinemia (HP:0002154)3.83894586
10Increased CSF lactate (HP:0002490)3.68509245
11Progressive muscle weakness (HP:0003323)3.63069059
12Abnormality of the labia minora (HP:0012880)3.54418888
13Acute encephalopathy (HP:0006846)3.52440651
14Impulsivity (HP:0100710)3.45554988
15Multiple enchondromatosis (HP:0005701)3.43183699
16Hyperglycinuria (HP:0003108)3.41856559
17Mitochondrial inheritance (HP:0001427)3.39828725
18Progressive macrocephaly (HP:0004481)3.39776014
19Atrioventricular block (HP:0001678)3.38032923
20Rough bone trabeculation (HP:0100670)3.34656421
21Abnormal mitochondria in muscle tissue (HP:0008316)3.29303003
22Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.29059051
23Patellar aplasia (HP:0006443)3.26979551
24Exercise-induced muscle cramps (HP:0003710)3.24262289
25Aplasia/Hypoplasia of the patella (HP:0006498)3.20715750
26Increased hepatocellular lipid droplets (HP:0006565)3.18822735
27Difficulty climbing stairs (HP:0003551)3.15356865
28Aplastic anemia (HP:0001915)3.15158256
29Lipid accumulation in hepatocytes (HP:0006561)3.13405599
30Testicular atrophy (HP:0000029)3.12354785
313-Methylglutaconic aciduria (HP:0003535)3.10832347
32Premature ovarian failure (HP:0008209)3.06038555
33Exercise-induced myalgia (HP:0003738)3.01795296
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.97539763
35Abnormality of alanine metabolism (HP:0010916)2.97539763
36Hyperalaninemia (HP:0003348)2.97539763
37Ventricular fibrillation (HP:0001663)2.95282974
38Ureteral duplication (HP:0000073)2.93745758
39Gout (HP:0001997)2.88858858
40Increased serum lactate (HP:0002151)2.88507722
41Secondary amenorrhea (HP:0000869)2.83221043
42Absent radius (HP:0003974)2.78020799
43Hepatocellular necrosis (HP:0001404)2.77318404
44Rhabdomyolysis (HP:0003201)2.76406656
45Heart block (HP:0012722)2.75174164
46Shoulder girdle muscle weakness (HP:0003547)2.72559946
47Pelvic girdle muscle weakness (HP:0003749)2.71305338
48Abnormality of glycine metabolism (HP:0010895)2.70607778
49Abnormality of serine family amino acid metabolism (HP:0010894)2.70607778
50Muscle fiber inclusion bodies (HP:0100299)2.68907064
51Methylmalonic acidemia (HP:0002912)2.66845478
52Molar tooth sign on MRI (HP:0002419)2.65369491
53Abnormality of midbrain morphology (HP:0002418)2.65369491
54Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.65081226
55Myopathic facies (HP:0002058)2.64093506
56Abnormality of the umbilical cord (HP:0010881)2.63809745
57Type I transferrin isoform profile (HP:0003642)2.62914713
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.61489679
59Aplasia involving forearm bones (HP:0009822)2.58869672
60Absent forearm bone (HP:0003953)2.58869672
61Cerebral edema (HP:0002181)2.57630222
62Renal Fanconi syndrome (HP:0001994)2.56921585
63Lactic acidosis (HP:0003128)2.56684609
64Abnormality of the anterior horn cell (HP:0006802)2.55059739
65Degeneration of anterior horn cells (HP:0002398)2.55059739
66Abnormal atrioventricular conduction (HP:0005150)2.54711726
67Hyperglycemia (HP:0003074)2.52861086
68Aplasia/Hypoplasia involving the musculature (HP:0001460)2.52548476
69Methylmalonic aciduria (HP:0012120)2.52109181
70Poor head control (HP:0002421)2.50802608
71Abnormal glycosylation (HP:0012345)2.50023394
72Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.50023394
73Abnormal protein N-linked glycosylation (HP:0012347)2.50023394
74Abnormal protein glycosylation (HP:0012346)2.50023394
75CNS hypomyelination (HP:0003429)2.48936360
76Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.48157140
77Decreased activity of mitochondrial respiratory chain (HP:0008972)2.48157140
78Abnormality of chromosome stability (HP:0003220)2.45265449
79Hepatic necrosis (HP:0002605)2.44600709
80Abnormality of serum amino acid levels (HP:0003112)2.44059510
81Ependymoma (HP:0002888)2.43372980
82Sudden death (HP:0001699)2.41781976
83Abnormal trabecular bone morphology (HP:0100671)2.41755416
84Muscle hypertrophy of the lower extremities (HP:0008968)2.40131167
85Rimmed vacuoles (HP:0003805)2.39499025
86Nemaline bodies (HP:0003798)2.37725073
87Pancreatic cysts (HP:0001737)2.37683093
88Abnormality of the musculature of the pelvis (HP:0001469)2.37466241
89Abnormality of the hip-girdle musculature (HP:0001445)2.37466241
90Unsteady gait (HP:0002317)2.36854339
91Amniotic constriction ring (HP:0009775)2.36476958
92Abnormality of placental membranes (HP:0011409)2.36476958
93Calf muscle hypertrophy (HP:0008981)2.35914221
94Congenital, generalized hypertrichosis (HP:0004540)2.34646032
95Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.33179797
96Exertional dyspnea (HP:0002875)2.32409882
97Ventricular tachycardia (HP:0004756)2.31445015
98Short tibia (HP:0005736)2.30698306
99CNS demyelination (HP:0007305)2.29906192
100Aplasia/Hypoplasia of the tibia (HP:0005772)2.23566138
101Respiratory failure (HP:0002878)2.23453190
102Aplasia/hypoplasia of the humerus (HP:0006507)2.21968360
103Oral leukoplakia (HP:0002745)2.19289741
104Delusions (HP:0000746)2.18923952
105Personality changes (HP:0000751)2.18506449
106Colon cancer (HP:0003003)2.18036053
107Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.16453883
108Increased connective tissue (HP:0009025)2.13767340
109Optic disc pallor (HP:0000543)2.13011114
110Difficulty running (HP:0009046)2.11944847
111Microvesicular hepatic steatosis (HP:0001414)2.10220556
112Death in infancy (HP:0001522)2.09834895
113Bifid tongue (HP:0010297)2.09164365
114Myoglobinuria (HP:0002913)2.08690999
115Sparse eyelashes (HP:0000653)2.05037059
116Meckel diverticulum (HP:0002245)2.03840671
117Abnormality of methionine metabolism (HP:0010901)2.02775589
118Squamous cell carcinoma (HP:0002860)2.02634630
119Cutaneous melanoma (HP:0012056)2.00549367
120Small intestinal stenosis (HP:0012848)1.99543784
121Duodenal stenosis (HP:0100867)1.99543784
122Spinal muscular atrophy (HP:0007269)1.99404102
123Posterior subcapsular cataract (HP:0007787)1.98681402
124Renal cortical cysts (HP:0000803)1.98417208
125Insulin-resistant diabetes mellitus (HP:0000831)1.98213824
126Aplasia/Hypoplasia of the fovea (HP:0008060)1.98190431
127Hypoplasia of the fovea (HP:0007750)1.98190431
128Trismus (HP:0000211)1.97821726
129Hyporeflexia of lower limbs (HP:0002600)1.97576240
130Progressive inability to walk (HP:0002505)1.97518454
131Patent foramen ovale (HP:0001655)1.97444403
132Abnormality of lateral ventricle (HP:0030047)1.96853944
133Stenosis of the external auditory canal (HP:0000402)1.95629706
134External ophthalmoplegia (HP:0000544)1.95520196
135Muscle fibrillation (HP:0010546)1.95244538
136Tetraplegia (HP:0002445)1.94469260
137Aplasia/hypoplasia of the uterus (HP:0008684)1.94256833
138EMG: neuropathic changes (HP:0003445)1.91936564
139Entropion (HP:0000621)1.91258989
140Abnormality of the pons (HP:0007361)1.90894295
141Abnormality of the ileum (HP:0001549)1.90843525
142Megaloblastic anemia (HP:0001889)1.89588600
143Abnormality of the preputium (HP:0100587)1.88720818
144Exercise intolerance (HP:0003546)1.88010593
145Calcaneovalgus deformity (HP:0001848)1.87760765
146Increased serum pyruvate (HP:0003542)1.87484643
147Dysautonomia (HP:0002459)1.86893275
148Pancreatic islet-cell hyperplasia (HP:0004510)1.86161046
149Median cleft lip (HP:0000161)1.85848774
150Breast aplasia (HP:0100783)1.85347644
151Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.85126604
152Horseshoe kidney (HP:0000085)1.84883923
153Pancytopenia (HP:0001876)1.84752027
154Chromosomal breakage induced by crosslinking agents (HP:0003221)1.84557242
155Lethargy (HP:0001254)1.84193090
156Atrophy/Degeneration involving motor neurons (HP:0007373)1.83321885
157Chromsome breakage (HP:0040012)1.82584308
158Reduced antithrombin III activity (HP:0001976)1.81818161
159Short palpebral fissure (HP:0012745)1.81634766
160Abnormal lung lobation (HP:0002101)1.81446177
161Inability to walk (HP:0002540)1.81346113
162Ventricular arrhythmia (HP:0004308)1.81143560
163Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80579903
164Abnormal spermatogenesis (HP:0008669)1.79263456
165Absent hand (HP:0004050)1.78869539
166Emotional lability (HP:0000712)1.78538441
167Deformed tarsal bones (HP:0008119)1.76828983
168Microretrognathia (HP:0000308)1.76562752
169Nausea (HP:0002018)1.75736333
170Abolished electroretinogram (ERG) (HP:0000550)1.74767327
171Progressive external ophthalmoplegia (HP:0000590)1.74409943
172Generalized aminoaciduria (HP:0002909)1.74297753
173Abnormality of DNA repair (HP:0003254)1.73854022
174Postnatal microcephaly (HP:0005484)1.73825523
175Leukodystrophy (HP:0002415)1.72966684
176Abnormality of the duodenum (HP:0002246)1.72703452
177Pendular nystagmus (HP:0012043)1.71742109
178IgG deficiency (HP:0004315)1.68166202
179Parakeratosis (HP:0001036)1.67187709

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.18497407
2WEE14.70337461
3NEK13.58720377
4MST43.55667819
5AKT32.96879313
6TSSK62.95886859
7EPHA22.94804972
8EIF2AK12.91249642
9TRIM282.89746476
10PLK42.82665684
11PBK2.75036995
12NEK22.46540135
13PDK42.40538477
14PDK32.40538477
15SRPK12.36840951
16TTK2.33337433
17PINK12.24392700
18PNCK2.20875125
19NUAK12.16131461
20MAP3K122.06535450
21BRSK21.98536452
22VRK21.96245346
23PLK11.93378440
24LATS21.91627820
25ZAK1.84859427
26PDK21.72479817
27STK161.71820937
28PLK31.68924888
29STK38L1.65039260
30NME21.64319449
31WNK31.62617491
32TAF11.62424693
33EIF2AK31.60579071
34TNIK1.54530361
35TTN1.53877140
36OBSCN1.53771842
37CDC71.51522449
38NME11.48375250
39BCR1.48268559
40BMPR1B1.47913692
41BRSK11.46101918
42FRK1.44422774
43MAP4K21.38364126
44DYRK31.35182470
45ADRBK21.35091967
46PLK21.34624500
47STK391.34483431
48ERBB41.34381552
49ERBB31.30798976
50ALK1.27900230
51ARAF1.23184516
52OXSR11.20457760
53CHEK21.19593612
54AURKB1.19572871
55AURKA1.17954711
56CDK121.14265776
57ACVR1B1.11172981
58GRK11.09225658
59PHKG21.09102488
60PHKG11.09102488
61BCKDK1.07505755
62BRAF1.05484862
63CCNB11.04777205
64TXK1.03822123
65TESK21.02274521
66IRAK30.93331866
67TESK10.92416633
68MAP3K80.92368128
69MKNK20.90530689
70MAP3K90.90008553
71CHEK10.87233838
72CDK70.86793322
73STK240.85665226
74CDK40.83342631
75STK30.80579953
76WNK40.78537255
77LIMK10.78370679
78MYLK0.76242661
79CDK90.76179630
80PRKCI0.75235226
81CSNK1G10.72440307
82TGFBR10.71718078
83TLK10.71255170
84STK380.70534463
85CSNK1G30.68123605
86CDK20.65694502
87PRKAA10.64083913
88STK40.63647271
89ATR0.63263834
90TIE10.63245941
91MAP3K50.62701004
92PAK10.60917181
93VRK10.60433053
94CSNK1G20.60410395
95PRKCE0.59335727
96MAP3K110.58708587
97PIM20.57231600
98EIF2AK20.56723850
99MAP3K40.55120093
100CSNK1E0.54141601
101RPS6KB20.53360496
102MARK30.53262581
103IKBKB0.53138361
104FER0.52064968
105RPS6KA40.51049660
106CSNK2A20.50212525
107CSNK1A1L0.48489618
108ABL20.47378029
109CSNK2A10.47185062
110CDK10.45361408
111DAPK10.44779996
112DYRK20.44129408
113GRK70.44072572
114INSRR0.43248523
115LATS10.42343717
116TGFBR20.42182113
117ATM0.41835418
118PAK30.40943993
119NEK60.39547304
120SIK30.39317256
121PIM10.39235435
122AKT20.38359278
123MKNK10.38322070
124MTOR0.38278072
125PIK3CG0.37935314
126PAK40.36579964
127TAOK10.36461692
128KDR0.35472875
129RAF10.33871725
130NLK0.33750382
131MAPKAPK30.33589088
132DAPK30.32852617
133FGFR10.32525018
134CLK10.31939062
135MELK0.29930437
136EGFR0.28451941
137TRIB30.28314562
138IGF1R0.28127361
139CDK80.27208951
140TAOK20.24307147
141MARK10.21750104
142STK100.21207533
143MAP2K30.21120998
144PRKCG0.20615077
145MAPK100.20544525
146PAK60.16816609
147GRK50.16713555
148CAMK2G0.16667335
149MAP3K30.16233525
150KSR20.15394988
151MAP3K60.15057660
152RPS6KA50.14929854

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.54302484
2RNA polymerase_Homo sapiens_hsa030204.44613430
3Vitamin B6 metabolism_Homo sapiens_hsa007504.41506679
4Proteasome_Homo sapiens_hsa030504.18164857
5Protein export_Homo sapiens_hsa030603.81579296
6RNA transport_Homo sapiens_hsa030133.42909921
7DNA replication_Homo sapiens_hsa030302.84463823
8Mismatch repair_Homo sapiens_hsa034302.67021568
9Spliceosome_Homo sapiens_hsa030402.45752476
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.37180271
11Pyrimidine metabolism_Homo sapiens_hsa002402.34594104
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.34289212
13Cell cycle_Homo sapiens_hsa041102.18116144
14Regulation of autophagy_Homo sapiens_hsa041402.07190730
15Homologous recombination_Homo sapiens_hsa034402.00975949
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.99857556
17Basal transcription factors_Homo sapiens_hsa030221.97987347
18Nucleotide excision repair_Homo sapiens_hsa034201.97318913
19Base excision repair_Homo sapiens_hsa034101.78448681
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.73955911
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71742543
22Pentose phosphate pathway_Homo sapiens_hsa000301.71406096
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70515174
24Ribosome_Homo sapiens_hsa030101.68003149
25Folate biosynthesis_Homo sapiens_hsa007901.65668127
26Biosynthesis of amino acids_Homo sapiens_hsa012301.62234711
27Carbon metabolism_Homo sapiens_hsa012001.57417666
28One carbon pool by folate_Homo sapiens_hsa006701.57325924
29Purine metabolism_Homo sapiens_hsa002301.56435983
30Fructose and mannose metabolism_Homo sapiens_hsa000511.56105433
31Fanconi anemia pathway_Homo sapiens_hsa034601.48584117
32Steroid biosynthesis_Homo sapiens_hsa001001.46909151
33Sulfur metabolism_Homo sapiens_hsa009201.46801636
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45683809
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.42284838
36Oocyte meiosis_Homo sapiens_hsa041141.40855262
37p53 signaling pathway_Homo sapiens_hsa041151.38160188
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36919554
39RNA degradation_Homo sapiens_hsa030181.30225519
40mRNA surveillance pathway_Homo sapiens_hsa030151.27758134
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26235710
42Epstein-Barr virus infection_Homo sapiens_hsa051691.22896461
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18167588
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17468273
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14149130
46Rheumatoid arthritis_Homo sapiens_hsa053231.13051158
47Fatty acid elongation_Homo sapiens_hsa000621.07017330
48Glycerophospholipid metabolism_Homo sapiens_hsa005641.04950186
49Huntingtons disease_Homo sapiens_hsa050161.02639901
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98608066
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96405215
52Cardiac muscle contraction_Homo sapiens_hsa042600.94040862
53Parkinsons disease_Homo sapiens_hsa050120.92688700
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.84895137
55Oxidative phosphorylation_Homo sapiens_hsa001900.84248391
56mTOR signaling pathway_Homo sapiens_hsa041500.80228904
57Circadian rhythm_Homo sapiens_hsa047100.77730342
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76618772
59Selenocompound metabolism_Homo sapiens_hsa004500.76084489
60Vibrio cholerae infection_Homo sapiens_hsa051100.72914008
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68470978
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67363828
63Sulfur relay system_Homo sapiens_hsa041220.65204737
64Graft-versus-host disease_Homo sapiens_hsa053320.63374058
65Phototransduction_Homo sapiens_hsa047440.61505839
66Asthma_Homo sapiens_hsa053100.60967501
67Galactose metabolism_Homo sapiens_hsa000520.60243065
68Arginine and proline metabolism_Homo sapiens_hsa003300.59368520
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58346750
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57476577
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56716203
72Type I diabetes mellitus_Homo sapiens_hsa049400.56479130
73Autoimmune thyroid disease_Homo sapiens_hsa053200.52922859
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52826072
75Allograft rejection_Homo sapiens_hsa053300.51871103
76Tryptophan metabolism_Homo sapiens_hsa003800.50554526
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50301663
78Primary immunodeficiency_Homo sapiens_hsa053400.50231415
79Peroxisome_Homo sapiens_hsa041460.50003472
80Metabolic pathways_Homo sapiens_hsa011000.48928795
81Lysosome_Homo sapiens_hsa041420.48474971
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46851472
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45983133
84TGF-beta signaling pathway_Homo sapiens_hsa043500.40545228
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40308429
86Non-homologous end-joining_Homo sapiens_hsa034500.39959581
87HIF-1 signaling pathway_Homo sapiens_hsa040660.39741907
88Insulin signaling pathway_Homo sapiens_hsa049100.39708102
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39216685
90N-Glycan biosynthesis_Homo sapiens_hsa005100.37565672
91Vitamin digestion and absorption_Homo sapiens_hsa049770.37451855
92Propanoate metabolism_Homo sapiens_hsa006400.35828102
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35462662
94Shigellosis_Homo sapiens_hsa051310.35413314
95AMPK signaling pathway_Homo sapiens_hsa041520.34767252
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.33919431
97Viral carcinogenesis_Homo sapiens_hsa052030.33541554
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33218310
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32754096
100Dilated cardiomyopathy_Homo sapiens_hsa054140.32427039
101Arginine biosynthesis_Homo sapiens_hsa002200.31643614
102FoxO signaling pathway_Homo sapiens_hsa040680.31107739
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.29550895
104Nitrogen metabolism_Homo sapiens_hsa009100.28964745
105Alzheimers disease_Homo sapiens_hsa050100.28804531
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27806845
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27500066
108Glutathione metabolism_Homo sapiens_hsa004800.26962684
109Caffeine metabolism_Homo sapiens_hsa002320.25715893
110Tight junction_Homo sapiens_hsa045300.25631495
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.23613892
112Pyruvate metabolism_Homo sapiens_hsa006200.22851978
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22773006
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22654253
115Glucagon signaling pathway_Homo sapiens_hsa049220.21402664
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20703825
117Sphingolipid metabolism_Homo sapiens_hsa006000.19842325
118Phagosome_Homo sapiens_hsa041450.19830674
119Antigen processing and presentation_Homo sapiens_hsa046120.18195357
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18182691
121Butanoate metabolism_Homo sapiens_hsa006500.17454770
122Hematopoietic cell lineage_Homo sapiens_hsa046400.16268509
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15930544
124Hippo signaling pathway_Homo sapiens_hsa043900.14820773
125beta-Alanine metabolism_Homo sapiens_hsa004100.13916106
126Herpes simplex infection_Homo sapiens_hsa051680.13779877
127HTLV-I infection_Homo sapiens_hsa051660.12631136
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.11058355
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.10935475
130Glycerolipid metabolism_Homo sapiens_hsa005610.10346303
131Fatty acid degradation_Homo sapiens_hsa000710.08898877
132Systemic lupus erythematosus_Homo sapiens_hsa053220.06534077
133Linoleic acid metabolism_Homo sapiens_hsa005910.06335768
134Thyroid cancer_Homo sapiens_hsa052160.05684357
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.04998280
136Collecting duct acid secretion_Homo sapiens_hsa049660.04435386
137Fatty acid metabolism_Homo sapiens_hsa012120.04075758
138Legionellosis_Homo sapiens_hsa051340.03677608
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.03547690

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