TIGD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K11-linked deubiquitination (GO:0035871)5.28875749
2monoubiquitinated protein deubiquitination (GO:0035520)5.23696746
3neural tube formation (GO:0001841)4.73399481
4positive regulation of developmental pigmentation (GO:0048087)4.62783115
5indole-containing compound catabolic process (GO:0042436)4.57129937
6indolalkylamine catabolic process (GO:0046218)4.57129937
7tryptophan catabolic process (GO:0006569)4.57129937
8indolalkylamine metabolic process (GO:0006586)4.44728602
9regulation of pigment cell differentiation (GO:0050932)4.44238929
10signal peptide processing (GO:0006465)4.39248481
11protein K48-linked deubiquitination (GO:0071108)4.27045592
12regulation of hippo signaling (GO:0035330)4.18148693
13cilium or flagellum-dependent cell motility (GO:0001539)4.12693242
14interkinetic nuclear migration (GO:0022027)4.09863249
15detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.08894904
16kynurenine metabolic process (GO:0070189)3.94782909
17tryptophan metabolic process (GO:0006568)3.92183332
18establishment of protein localization to Golgi (GO:0072600)3.89216803
19snRNA transcription (GO:0009301)3.70132284
20cellular response to ethanol (GO:0071361)3.64295573
21detection of light stimulus involved in visual perception (GO:0050908)3.57231422
22detection of light stimulus involved in sensory perception (GO:0050962)3.57231422
23protein K63-linked deubiquitination (GO:0070536)3.56018414
24photoreceptor cell maintenance (GO:0045494)3.52798961
25regulation of sarcomere organization (GO:0060297)3.49450568
26UDP-N-acetylglucosamine metabolic process (GO:0006047)3.45364810
27protein prenylation (GO:0018342)3.40638165
28prenylation (GO:0097354)3.40638165
29lipid translocation (GO:0034204)3.39761841
30phospholipid translocation (GO:0045332)3.39761841
31negative regulation of translation, ncRNA-mediated (GO:0040033)3.33111148
32regulation of translation, ncRNA-mediated (GO:0045974)3.33111148
33negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.33111148
34reflex (GO:0060004)3.29529575
35phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.28862748
36cellular response to sterol (GO:0036315)3.19411414
37tachykinin receptor signaling pathway (GO:0007217)3.17640680
38negative regulation of cytosolic calcium ion concentration (GO:0051481)3.15439124
39DNA double-strand break processing (GO:0000729)3.09337194
40regulation of establishment of cell polarity (GO:2000114)3.08865454
41central nervous system neuron axonogenesis (GO:0021955)3.07649113
42indole-containing compound metabolic process (GO:0042430)3.07572473
43negative regulation of calcium ion transport into cytosol (GO:0010523)3.06736450
44microtubule anchoring (GO:0034453)3.06151662
45behavioral response to ethanol (GO:0048149)3.04473645
46regulation of posttranscriptional gene silencing (GO:0060147)3.00203226
47regulation of gene silencing by miRNA (GO:0060964)3.00203226
48regulation of gene silencing by RNA (GO:0060966)3.00203226
49L-fucose catabolic process (GO:0042355)2.98182837
50fucose catabolic process (GO:0019317)2.98182837
51L-fucose metabolic process (GO:0042354)2.98182837
52double-strand break repair via homologous recombination (GO:0000724)2.95467985
53auditory receptor cell stereocilium organization (GO:0060088)2.92357674
54recombinational repair (GO:0000725)2.91883260
55cellular ketone body metabolic process (GO:0046950)2.90691341
56cytoplasmic mRNA processing body assembly (GO:0033962)2.89687446
57histone H3-K9 methylation (GO:0051567)2.87235618
58detection of mechanical stimulus involved in sensory perception (GO:0050974)2.84731595
59thyroid hormone metabolic process (GO:0042403)2.84025880
60histone H3-K4 trimethylation (GO:0080182)2.82914334
61retinal cone cell development (GO:0046549)2.82642023
62gamma-aminobutyric acid transport (GO:0015812)2.78659845
63rRNA catabolic process (GO:0016075)2.78480870
64NAD biosynthetic process (GO:0009435)2.76497413
65benzene-containing compound metabolic process (GO:0042537)2.76105632
66replication fork processing (GO:0031297)2.72690648
67amine catabolic process (GO:0009310)2.71941815
68cellular biogenic amine catabolic process (GO:0042402)2.71941815
69regulation of establishment or maintenance of cell polarity (GO:0032878)2.71277595
70righting reflex (GO:0060013)2.71169628
71reciprocal DNA recombination (GO:0035825)2.71008378
72reciprocal meiotic recombination (GO:0007131)2.71008378
73protein targeting to Golgi (GO:0000042)2.64731433
74cAMP catabolic process (GO:0006198)2.64103802
75nucleus localization (GO:0051647)2.63579720
76ketone body metabolic process (GO:1902224)2.62683990
77inner ear receptor stereocilium organization (GO:0060122)2.62604149
78behavioral response to nicotine (GO:0035095)2.62583066
79sphingoid metabolic process (GO:0046519)2.61504675
80oxidative demethylation (GO:0070989)2.61210343
81central nervous system projection neuron axonogenesis (GO:0021952)2.60912860
82serotonin metabolic process (GO:0042428)2.60598089
83positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.58358230
84cyclic nucleotide catabolic process (GO:0009214)2.57468663
85negative regulation of sodium ion transport (GO:0010766)2.57364170
86retrograde transport, vesicle recycling within Golgi (GO:0000301)2.57262909
87pericardium development (GO:0060039)2.56935368
88flavonoid metabolic process (GO:0009812)2.56877581
89epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.51177911
90gene silencing by RNA (GO:0031047)2.49693407
91negative regulation of keratinocyte proliferation (GO:0010839)2.46788305
92proline transport (GO:0015824)2.46673757
93histone mRNA catabolic process (GO:0071044)2.42295997
94negative regulation of systemic arterial blood pressure (GO:0003085)2.42107403
95cilium organization (GO:0044782)2.42097679
96histone lysine methylation (GO:0034968)2.40766295
97cilium assembly (GO:0042384)2.40210758
98protein targeting to vacuole (GO:0006623)2.38219395
99protein targeting to lysosome (GO:0006622)2.38219395
100establishment of protein localization to vacuole (GO:0072666)2.38219395

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.66661178
2CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.93913235
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.78687904
4IGF1R_20145208_ChIP-Seq_DFB_Human2.72464569
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.68871074
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.65298641
7VDR_22108803_ChIP-Seq_LS180_Human2.59428555
8ZNF274_21170338_ChIP-Seq_K562_Hela2.59017114
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.56659582
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.51382548
11TAF15_26573619_Chip-Seq_HEK293_Human2.43910317
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.35643434
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29530461
14AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.28953147
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.18949289
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.14998523
17FUS_26573619_Chip-Seq_HEK293_Human2.13277565
18P300_19829295_ChIP-Seq_ESCs_Human2.12791869
19EWS_26573619_Chip-Seq_HEK293_Human2.08997268
20STAT3_23295773_ChIP-Seq_U87_Human2.04001009
21SMAD4_21799915_ChIP-Seq_A2780_Human1.95135726
22ER_23166858_ChIP-Seq_MCF-7_Human1.95049763
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.91516962
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.90715195
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.86772057
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82537204
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.80478519
28AR_21572438_ChIP-Seq_LNCaP_Human1.79500812
29TCF4_23295773_ChIP-Seq_U87_Human1.76719470
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.76360180
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73630903
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.71875614
33NR3C1_21868756_ChIP-Seq_MCF10A_Human1.65376730
34CBP_20019798_ChIP-Seq_JUKART_Human1.64340398
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64340398
36BCAT_22108803_ChIP-Seq_LS180_Human1.63803778
37TP53_16413492_ChIP-PET_HCT116_Human1.63191680
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.62059111
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54774120
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.54204795
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54204795
42AR_25329375_ChIP-Seq_VCAP_Human1.53873356
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53585673
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.52845824
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52633055
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.50626428
47EZH2_22144423_ChIP-Seq_EOC_Human1.49833825
48TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.49486117
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46960215
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46888793
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46881378
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46814165
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.40509279
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38864426
55TCF4_22108803_ChIP-Seq_LS180_Human1.38400993
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38126108
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36879946
58FLI1_21867929_ChIP-Seq_TH2_Mouse1.36665115
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.34433853
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.32573274
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32286937
62PRDM14_20953172_ChIP-Seq_ESCs_Human1.30742085
63RUNX2_22187159_ChIP-Seq_PCA_Human1.30622435
64AHR_22903824_ChIP-Seq_MCF-7_Human1.29627599
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.28301493
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26506216
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25688312
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24044787
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.23456521
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20880013
71OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19008208
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.18030153
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.15539089
74* CDX2_22108803_ChIP-Seq_LS180_Human1.15525915
75FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15422101
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.15116438
77TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14931301
78P53_22387025_ChIP-Seq_ESCs_Mouse1.13778526
79CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13167929
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12541386
81KDM2B_26808549_Chip-Seq_REH_Human1.10925062
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10846585
83IRF1_19129219_ChIP-ChIP_H3396_Human1.10020519
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08811672
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07149724
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07149724
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06753865
88SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06248263
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05489363
90NANOG_19829295_ChIP-Seq_ESCs_Human1.05316827
91SOX2_19829295_ChIP-Seq_ESCs_Human1.05316827
92CMYC_18555785_Chip-Seq_ESCs_Mouse1.05266994
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04032378
94FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04012814
95P300_18555785_Chip-Seq_ESCs_Mouse1.03422374
96RXR_22108803_ChIP-Seq_LS180_Human1.02665830
97DROSHA_22980978_ChIP-Seq_HELA_Human1.01546222
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01242049
99STAT3_18555785_Chip-Seq_ESCs_Mouse1.00975423
100TP53_22573176_ChIP-Seq_HFKS_Human1.00804163

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.77256507
2MP0000569_abnormal_digit_pigmentation5.52237848
3MP0003195_calcinosis2.98705670
4MP0003646_muscle_fatigue2.69842219
5MP0008877_abnormal_DNA_methylation2.45553107
6MP0009046_muscle_twitch2.35609035
7MP0001501_abnormal_sleep_pattern2.29505404
8MP0005551_abnormal_eye_electrophysiolog2.25481962
9MP0004043_abnormal_pH_regulation2.10216936
10MP0000372_irregular_coat_pigmentation2.04156903
11MP0000427_abnormal_hair_cycle2.03066370
12MP0003045_fibrosis2.00650521
13MP0003950_abnormal_plasma_membrane1.92329425
14MP0000383_abnormal_hair_follicle1.92198525
15MP0005174_abnormal_tail_pigmentation1.84973474
16MP0001968_abnormal_touch/_nociception1.74636425
17MP0005645_abnormal_hypothalamus_physiol1.72409403
18MP0006276_abnormal_autonomic_nervous1.67453827
19MP0005253_abnormal_eye_physiology1.64722242
20MP0002138_abnormal_hepatobiliary_system1.59657790
21MP0002736_abnormal_nociception_after1.58233139
22MP0005310_abnormal_salivary_gland1.56954936
23MP0002168_other_aberrant_phenotype1.56145684
24MP0002102_abnormal_ear_morphology1.54902403
25MP0003890_abnormal_embryonic-extraembry1.54797589
26MP0003787_abnormal_imprinting1.48777559
27MP0005646_abnormal_pituitary_gland1.48195877
28MP0009745_abnormal_behavioral_response1.44656547
29MP0001486_abnormal_startle_reflex1.44251206
30MP0001984_abnormal_olfaction1.41723388
31MP0003136_yellow_coat_color1.35439534
32MP0002638_abnormal_pupillary_reflex1.33861277
33MP0010094_abnormal_chromosome_stability1.32892868
34MP0004142_abnormal_muscle_tone1.32007679
35MP0002837_dystrophic_cardiac_calcinosis1.30829196
36MP0000015_abnormal_ear_pigmentation1.28032047
37MP0002928_abnormal_bile_duct1.27715818
38MP0010386_abnormal_urinary_bladder1.26312929
39MP0005395_other_phenotype1.25668999
40MP0000631_abnormal_neuroendocrine_gland1.22567504
41MP0005670_abnormal_white_adipose1.22565838
42MP0003718_maternal_effect1.21298590
43MP0008058_abnormal_DNA_repair1.20155793
44MP0006054_spinal_hemorrhage1.19827504
45MP0002735_abnormal_chemical_nociception1.19346123
46MP0005386_behavior/neurological_phenoty1.18530367
47MP0004924_abnormal_behavior1.18530367
48MP0002009_preneoplasia1.17900144
49MP0004145_abnormal_muscle_electrophysio1.17867116
50MP0000371_diluted_coat_color1.13187604
51MP0005075_abnormal_melanosome_morpholog1.12039019
52MP0008872_abnormal_physiological_respon1.11112985
53MP0003252_abnormal_bile_duct1.10660278
54MP0010678_abnormal_skin_adnexa1.09668279
55MP0005266_abnormal_metabolism1.09062943
56MP0002272_abnormal_nervous_system1.08945183
57MP0004147_increased_porphyrin_level1.08021436
58MP0006292_abnormal_olfactory_placode1.06669035
59MP0002095_abnormal_skin_pigmentation1.06290189
60MP0002938_white_spotting1.05823304
61MP0002064_seizures1.05793870
62MP0008961_abnormal_basal_metabolism1.05061392
63MP0005647_abnormal_sex_gland1.04160663
64MP0001986_abnormal_taste_sensitivity1.03159998
65MP0002067_abnormal_sensory_capabilities1.03131065
66MP0005171_absent_coat_pigmentation1.00345993
67MP0002572_abnormal_emotion/affect_behav0.99730627
68MP0006072_abnormal_retinal_apoptosis0.99190822
69MP0003633_abnormal_nervous_system0.95758685
70MP0002876_abnormal_thyroid_physiology0.95622076
71MP0005167_abnormal_blood-brain_barrier0.94189053
72MP0001485_abnormal_pinna_reflex0.93836159
73MP0008995_early_reproductive_senescence0.93355341
74MP0005187_abnormal_penis_morphology0.92710154
75MP0002229_neurodegeneration0.92114211
76MP0009697_abnormal_copulation0.91876042
77MP0005085_abnormal_gallbladder_physiolo0.91013940
78MP0003698_abnormal_male_reproductive0.90656024
79MP0004130_abnormal_muscle_cell0.90555910
80MP0004215_abnormal_myocardial_fiber0.90523448
81MP0002557_abnormal_social/conspecific_i0.89145358
82MP0004381_abnormal_hair_follicle0.87804181
83MP0003943_abnormal_hepatobiliary_system0.86178641
84MP0003635_abnormal_synaptic_transmissio0.84949101
85MP0000538_abnormal_urinary_bladder0.84349846
86MP0000778_abnormal_nervous_system0.83448138
87MP0003631_nervous_system_phenotype0.79288292
88MP0000230_abnormal_systemic_arterial0.78325726
89MP0000516_abnormal_urinary_system0.78130160
90MP0005367_renal/urinary_system_phenotyp0.78130160
91MP0003937_abnormal_limbs/digits/tail_de0.78028754
92MP0003880_abnormal_central_pattern0.77953612
93MP0001970_abnormal_pain_threshold0.74855368
94MP0001929_abnormal_gametogenesis0.74336428
95MP0002160_abnormal_reproductive_system0.73496543
96MP0005389_reproductive_system_phenotype0.71585360
97MP0005195_abnormal_posterior_eye0.71363833
98MP0003632_abnormal_nervous_system0.71264140
99MP0002063_abnormal_learning/memory/cond0.68973972
100MP0002332_abnormal_exercise_endurance0.68692429

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)4.69108887
2Hyperventilation (HP:0002883)4.54883598
3Gaze-evoked nystagmus (HP:0000640)4.22965100
4Pancreatic cysts (HP:0001737)4.19757242
5Progressive cerebellar ataxia (HP:0002073)3.70449996
6Pancreatic fibrosis (HP:0100732)3.54995715
7True hermaphroditism (HP:0010459)3.44336043
8Chronic hepatic failure (HP:0100626)3.40307941
9Febrile seizures (HP:0002373)3.27436584
10Attenuation of retinal blood vessels (HP:0007843)3.16813585
11Fair hair (HP:0002286)3.16621761
12Abnormality of the renal cortex (HP:0011035)3.06015876
13Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.03280775
14Abnormality of midbrain morphology (HP:0002418)2.97161646
15Molar tooth sign on MRI (HP:0002419)2.97161646
16Protruding tongue (HP:0010808)2.97149749
17Absent speech (HP:0001344)2.93466028
18Central scotoma (HP:0000603)2.91381658
19Clumsiness (HP:0002312)2.91023260
20Aplasia/Hypoplasia of the tibia (HP:0005772)2.87094962
21Nephronophthisis (HP:0000090)2.81758210
22Abnormality of the renal medulla (HP:0100957)2.81722313
23Congenital stationary night blindness (HP:0007642)2.80672700
24Cystic liver disease (HP:0006706)2.64396811
25Increased neuronal autofluorescent lipopigment (HP:0002074)2.55754931
26Medial flaring of the eyebrow (HP:0010747)2.46741739
27Generalized hypopigmentation of hair (HP:0011358)2.44596930
28Bony spicule pigmentary retinopathy (HP:0007737)2.42964785
29Widely spaced teeth (HP:0000687)2.42513015
30Cerebellar dysplasia (HP:0007033)2.41759150
31Congenital sensorineural hearing impairment (HP:0008527)2.40863512
32Intestinal atresia (HP:0011100)2.39056254
33Volvulus (HP:0002580)2.37732845
34Chromsome breakage (HP:0040012)2.35182316
35Dialeptic seizures (HP:0011146)2.31113518
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.29520619
37Broad-based gait (HP:0002136)2.28238589
38Aplasia/Hypoplasia of the tongue (HP:0010295)2.27351289
39Tubulointerstitial nephritis (HP:0001970)2.26042262
40Tubular atrophy (HP:0000092)2.23581519
41Abnormality of chromosome stability (HP:0003220)2.20514558
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.18946568
43Progressive inability to walk (HP:0002505)2.18207459
44Focal seizures (HP:0007359)2.15748083
45Abolished electroretinogram (ERG) (HP:0000550)2.14930859
46Clubbing of toes (HP:0100760)2.12512926
47Scotoma (HP:0000575)2.11632489
48Type II lissencephaly (HP:0007260)2.08998537
49Dysmetric saccades (HP:0000641)2.08269812
50Increased corneal curvature (HP:0100692)2.08200009
51Keratoconus (HP:0000563)2.08200009
52Cupped ear (HP:0000378)2.07726182
53Decreased circulating renin level (HP:0003351)2.07340123
54Absence seizures (HP:0002121)2.05443948
55Congenital hepatic fibrosis (HP:0002612)2.04175742
56Thyroiditis (HP:0100646)2.02680516
57Tented upper lip vermilion (HP:0010804)2.02069094
58Renal cortical cysts (HP:0000803)2.01663706
59Congenital primary aphakia (HP:0007707)2.00186724
60Drooling (HP:0002307)1.99778373
61Inability to walk (HP:0002540)1.99597709
62Sloping forehead (HP:0000340)1.99580805
63Facial diplegia (HP:0001349)1.99512267
64Hypoplastic labia majora (HP:0000059)1.99113983
65Small hand (HP:0200055)1.97532894
66Polydipsia (HP:0001959)1.97428948
67Abnormal drinking behavior (HP:0030082)1.97428948
68Gait imbalance (HP:0002141)1.97157374
69Poor coordination (HP:0002370)1.96721532
70Astigmatism (HP:0000483)1.95814779
71Preaxial foot polydactyly (HP:0001841)1.95205657
72Genital tract atresia (HP:0001827)1.95059681
73Submucous cleft hard palate (HP:0000176)1.94921045
74Abnormality of the labia majora (HP:0012881)1.94684151
75Stomach cancer (HP:0012126)1.94583180
76Highly arched eyebrow (HP:0002553)1.87561123
77Atonic seizures (HP:0010819)1.87087916
78Postaxial foot polydactyly (HP:0001830)1.86965707
79Enlarged kidneys (HP:0000105)1.85955118
80Abnormality of the ischium (HP:0003174)1.85599951
81Bile duct proliferation (HP:0001408)1.85376593
82Abnormal biliary tract physiology (HP:0012439)1.85376593
83Patellar aplasia (HP:0006443)1.83505921
84Furrowed tongue (HP:0000221)1.82272860
85Urinary bladder sphincter dysfunction (HP:0002839)1.81491535
86Vaginal atresia (HP:0000148)1.81263791
87Short foot (HP:0001773)1.80715406
88Nephrogenic diabetes insipidus (HP:0009806)1.79109214
89Excessive salivation (HP:0003781)1.77729933
90Focal motor seizures (HP:0011153)1.76927608
91Increased cerebral lipofuscin (HP:0011813)1.74851634
92Tubulointerstitial abnormality (HP:0001969)1.74078299
93Short chin (HP:0000331)1.73595182
94Hypoplastic ischia (HP:0003175)1.73160781
95Preaxial hand polydactyly (HP:0001177)1.71461297
96Astrocytoma (HP:0009592)1.71296807
97Abnormality of the astrocytes (HP:0100707)1.71296807
98Thyroid-stimulating hormone excess (HP:0002925)1.70849309
99Abnormality of macular pigmentation (HP:0008002)1.70668995
100Lissencephaly (HP:0001339)1.70064791

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.77235574
2ACVR1B3.30933573
3BMPR1B2.95957930
4WNK32.26101485
5AKT31.95984605
6MKNK21.89716018
7CASK1.81005194
8TAOK31.77863867
9STK38L1.77188871
10ADRBK21.77110802
11MAPK131.75528822
12NUAK11.73485987
13MAP4K21.68825784
14MAP3K41.64240519
15LATS11.51997099
16PIK3CG1.45821981
17INSRR1.45554495
18ZAK1.43127810
19STK391.39488419
20BRD41.37851095
21OXSR11.33948704
22BRSK21.31402104
23PINK11.25249531
24NTRK31.13573011
25GRK11.12971246
26TEC1.09018385
27TNIK1.04292291
28CAMK1G1.01875840
29NLK0.99224588
30SGK20.98358683
31TRIM280.95829648
32MKNK10.91998117
33MELK0.91294205
34ADRBK10.89487945
35PAK30.85716103
36CAMK1D0.85282090
37CDK120.85238622
38FER0.84463589
39EIF2AK30.83544145
40TGFBR10.83394423
41MAP3K70.82157205
42OBSCN0.80994318
43PTK2B0.80486821
44CAMKK20.80359757
45TXK0.76738282
46PIK3CA0.76694284
47PRKAA20.76330612
48EPHA40.74365129
49STK30.73667665
50BCR0.73518101
51ERBB30.73218376
52PRKCE0.71752874
53FGFR20.70390057
54IRAK10.69101315
55TRPM70.66356497
56PLK20.64603511
57STK380.64520127
58PDK20.60512190
59BLK0.58003509
60DAPK20.57913129
61TNK20.57487490
62MARK10.57064444
63CAMK40.56907178
64PRKAA10.53922836
65CSNK1A1L0.52184685
66PLK40.51539435
67ATM0.51208674
68EPHA30.48513453
69ATR0.46448340
70MAP2K70.44736603
71MARK30.44103913
72MAPK110.44061875
73SGK2230.43794369
74SGK4940.43794369
75PKN10.42930630
76CSNK1D0.42740642
77CSNK1G10.42731229
78FLT30.42115156
79WNK40.41705128
80CAMK10.41455857
81CAMK2A0.40796349
82SGK10.37635392
83CHEK20.37401282
84PRKCG0.36190119
85CHUK0.35139599
86STK110.33626367
87NEK60.33615509
88SGK30.33362065
89PRKACB0.33331562
90ERBB20.33330632
91DYRK1A0.31811000
92ITK0.30891139
93CSNK1G20.30200678
94GSK3B0.28794615
95WNK10.28010830
96PRKCB0.26455778
97CDK30.26208425
98KIT0.25408576
99CSNK1A10.24554727
100PIM10.24505802

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006502.64532138
2ABC transporters_Homo sapiens_hsa020102.35029848
3Phototransduction_Homo sapiens_hsa047442.31057062
4Homologous recombination_Homo sapiens_hsa034402.27729715
5Nicotine addiction_Homo sapiens_hsa050332.25590737
6Fanconi anemia pathway_Homo sapiens_hsa034602.25308570
7Tryptophan metabolism_Homo sapiens_hsa003802.07403198
8Non-homologous end-joining_Homo sapiens_hsa034502.01825920
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.01001895
10Nitrogen metabolism_Homo sapiens_hsa009101.96117582
11Taste transduction_Homo sapiens_hsa047421.90013135
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.89409026
13Linoleic acid metabolism_Homo sapiens_hsa005911.86311515
14Lysine degradation_Homo sapiens_hsa003101.86071778
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.81483419
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.79578765
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75044962
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.71334716
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.70228566
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65136073
21Selenocompound metabolism_Homo sapiens_hsa004501.60265363
22Ether lipid metabolism_Homo sapiens_hsa005651.52556876
23Morphine addiction_Homo sapiens_hsa050321.52375940
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44214743
25Olfactory transduction_Homo sapiens_hsa047401.44048443
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41267997
27Propanoate metabolism_Homo sapiens_hsa006401.40587055
28Dorso-ventral axis formation_Homo sapiens_hsa043201.37196805
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31424694
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27026862
31Glycerolipid metabolism_Homo sapiens_hsa005611.26322836
32Calcium signaling pathway_Homo sapiens_hsa040201.25391189
33Glutamatergic synapse_Homo sapiens_hsa047241.22301064
34Circadian entrainment_Homo sapiens_hsa047131.21629213
35Serotonergic synapse_Homo sapiens_hsa047261.21170125
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20901758
37Salivary secretion_Homo sapiens_hsa049701.18957184
38Histidine metabolism_Homo sapiens_hsa003401.14846377
39Circadian rhythm_Homo sapiens_hsa047101.13751683
40Ovarian steroidogenesis_Homo sapiens_hsa049131.11518293
41GABAergic synapse_Homo sapiens_hsa047271.09880777
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98564517
43Fatty acid biosynthesis_Homo sapiens_hsa000610.95578800
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.95499496
45beta-Alanine metabolism_Homo sapiens_hsa004100.94480942
46Retinol metabolism_Homo sapiens_hsa008300.93376273
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93233233
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90813859
49Basal transcription factors_Homo sapiens_hsa030220.89851775
50Sphingolipid metabolism_Homo sapiens_hsa006000.88967635
51Cholinergic synapse_Homo sapiens_hsa047250.88843587
52Long-term depression_Homo sapiens_hsa047300.86977717
53Type II diabetes mellitus_Homo sapiens_hsa049300.86080247
54Chemical carcinogenesis_Homo sapiens_hsa052040.84483609
55Insulin secretion_Homo sapiens_hsa049110.78050360
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76250857
57Regulation of autophagy_Homo sapiens_hsa041400.73523251
58Caffeine metabolism_Homo sapiens_hsa002320.73495862
59Renin secretion_Homo sapiens_hsa049240.71121028
60FoxO signaling pathway_Homo sapiens_hsa040680.70611218
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70402491
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.69900567
63cAMP signaling pathway_Homo sapiens_hsa040240.69783393
64Oxytocin signaling pathway_Homo sapiens_hsa049210.68401370
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.68274513
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66291323
67TGF-beta signaling pathway_Homo sapiens_hsa043500.63121946
68Fatty acid degradation_Homo sapiens_hsa000710.60413244
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59469407
70Platelet activation_Homo sapiens_hsa046110.58730798
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57593223
72Dopaminergic synapse_Homo sapiens_hsa047280.57074791
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56326620
74Peroxisome_Homo sapiens_hsa041460.56247017
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.55612962
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55039410
77RNA degradation_Homo sapiens_hsa030180.54760540
78Arachidonic acid metabolism_Homo sapiens_hsa005900.52602280
79Gastric acid secretion_Homo sapiens_hsa049710.51704882
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50794343
81RNA polymerase_Homo sapiens_hsa030200.50691870
82Inositol phosphate metabolism_Homo sapiens_hsa005620.47741451
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47686853
84One carbon pool by folate_Homo sapiens_hsa006700.47426821
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46661663
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44725316
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.44028367
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43389215
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41864789
90Systemic lupus erythematosus_Homo sapiens_hsa053220.40766439
91Pancreatic secretion_Homo sapiens_hsa049720.40743849
92Choline metabolism in cancer_Homo sapiens_hsa052310.39109881
93Fatty acid metabolism_Homo sapiens_hsa012120.39012459
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38395276
95Purine metabolism_Homo sapiens_hsa002300.37301903
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35810517
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34893233
98Melanoma_Homo sapiens_hsa052180.34649725
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33149569
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31573768

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