TIGD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1V(D)J recombination (GO:0033151)6.94345124
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.89112790
3negative regulation of thymocyte apoptotic process (GO:0070244)5.80456725
4DNA unwinding involved in DNA replication (GO:0006268)5.44177182
5DNA topological change (GO:0006265)5.40639103
6regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.72365386
7resolution of meiotic recombination intermediates (GO:0000712)4.63279224
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.52285672
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.52285672
10positive regulation of gamma-delta T cell activation (GO:0046645)4.48168297
11eosinophil chemotaxis (GO:0048245)4.10430287
12response to hydroperoxide (GO:0033194)4.09315827
13positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.96804489
14T cell migration (GO:0072678)3.96058474
15antigen processing and presentation of endogenous antigen (GO:0019883)3.95354722
16COPII vesicle coating (GO:0048208)3.94350272
17regulation of RNA export from nucleus (GO:0046831)3.88599100
18regulation of B cell receptor signaling pathway (GO:0050855)3.87178383
19ribosomal small subunit assembly (GO:0000028)3.86933536
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.83125183
21hepatocyte differentiation (GO:0070365)3.81955099
22cellular response to ethanol (GO:0071361)3.80999117
23interferon-gamma production (GO:0032609)3.79453784
24response to interleukin-15 (GO:0070672)3.71769357
25antigen processing and presentation via MHC class Ib (GO:0002475)3.70291590
26omega-hydroxylase P450 pathway (GO:0097267)3.63926536
27DNA deamination (GO:0045006)3.61934918
28nuclear pore complex assembly (GO:0051292)3.61616679
29eosinophil migration (GO:0072677)3.58381470
30viral transcription (GO:0019083)3.56976200
31negative regulation of fibrinolysis (GO:0051918)3.53330818
32regulation of gamma-delta T cell differentiation (GO:0045586)3.51302215
33cellular response to interleukin-15 (GO:0071350)3.51069947
34urea metabolic process (GO:0019627)3.46249538
35mast cell activation (GO:0045576)3.42387407
36somatic cell DNA recombination (GO:0016444)3.41634814
37somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.41634814
38nuclear pore organization (GO:0006999)3.41201469
39histone monoubiquitination (GO:0010390)3.39565503
40translational termination (GO:0006415)3.36764853
41positive regulation of macrophage differentiation (GO:0045651)3.35796048
42regulation of fibrinolysis (GO:0051917)3.34084128
43regulation of regulatory T cell differentiation (GO:0045589)3.33236321
44positive regulation of B cell differentiation (GO:0045579)3.29337640
45L-serine metabolic process (GO:0006563)3.27972865
46neutrophil activation involved in immune response (GO:0002283)3.27486891
47SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.27021604
48cotranslational protein targeting to membrane (GO:0006613)3.22931952
49positive regulation of T cell mediated cytotoxicity (GO:0001916)3.22832655
50sister chromatid segregation (GO:0000819)3.21863141
51regulation of nucleobase-containing compound transport (GO:0032239)3.21544627
52lymph node development (GO:0048535)3.21281151
53protein targeting to ER (GO:0045047)3.20391764
54urea cycle (GO:0000050)3.20121143
55mature B cell differentiation (GO:0002335)3.18624751
56mature B cell differentiation involved in immune response (GO:0002313)3.18452468
57glyoxylate metabolic process (GO:0046487)3.18157445
58regulation of translation in response to stress (GO:0043555)3.17915307
59regulation of isotype switching to IgG isotypes (GO:0048302)3.17242964
60T cell homeostasis (GO:0043029)3.16777214
61positive regulation of interferon-alpha production (GO:0032727)3.15648550
62T cell differentiation in thymus (GO:0033077)3.15288373
63regulation of histone H3-K9 methylation (GO:0051570)3.13341639
64regulation of alpha-beta T cell proliferation (GO:0046640)3.12347398
65monoubiquitinated protein deubiquitination (GO:0035520)3.12073961
66response to interferon-beta (GO:0035456)3.10877191
67cellular response to type I interferon (GO:0071357)3.10865640
68type I interferon signaling pathway (GO:0060337)3.10865640
69somatic diversification of immune receptors (GO:0002200)3.10425505
70response to type I interferon (GO:0034340)3.10377345
71regulation of T cell mediated cytotoxicity (GO:0001914)3.08898512
72regulation of gamma-delta T cell activation (GO:0046643)3.08769369
73GTP biosynthetic process (GO:0006183)3.07692052
74regulation of T-helper 1 cell differentiation (GO:0045625)3.07208110
75positive regulation of DNA recombination (GO:0045911)3.06518923
76response to protozoan (GO:0001562)3.05383414
77protein localization to endoplasmic reticulum (GO:0070972)3.04063799
78Arp2/3 complex-mediated actin nucleation (GO:0034314)3.03865114
79deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.03709630
80establishment of protein localization to endoplasmic reticulum (GO:0072599)3.02957037
81nitrogen cycle metabolic process (GO:0071941)3.02639126
82positive regulation of defense response to virus by host (GO:0002230)3.02340090
83pyrimidine dimer repair (GO:0006290)3.02333661
84positive regulation of isotype switching (GO:0045830)3.00425172
85defense response to protozoan (GO:0042832)2.99517963
86purine ribonucleotide transport (GO:0015868)2.99411682
87centrosome duplication (GO:0051298)2.99255321
88mitotic sister chromatid cohesion (GO:0007064)2.97697593
89regulation of female gonad development (GO:2000194)2.96674116
90regulation of interferon-alpha production (GO:0032647)2.96634344
91negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.95535590
92negative regulation of cell killing (GO:0031342)2.95535590
93B cell receptor signaling pathway (GO:0050853)2.95342866
94very-low-density lipoprotein particle assembly (GO:0034379)2.94028649
95regulation of B cell differentiation (GO:0045577)2.93706048
96cellular response to virus (GO:0098586)2.93630011
97CTP metabolic process (GO:0046036)2.91541818
98CTP biosynthetic process (GO:0006241)2.91541818
99regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.90460142
100positive regulation of alpha-beta T cell proliferation (GO:0046641)2.90151164
101negative regulation of translational initiation (GO:0045947)2.89630591
102regulation of thymocyte apoptotic process (GO:0070243)2.87387101
103cellular response to interferon-beta (GO:0035458)2.86889821
104mitotic chromosome condensation (GO:0007076)2.86254723
105respiratory burst (GO:0045730)2.84697822
106negative T cell selection (GO:0043383)2.83014936
107leukocyte aggregation (GO:0070486)2.82523858
108serine family amino acid biosynthetic process (GO:0009070)2.79488520
109regulation of interleukin-12 biosynthetic process (GO:0045075)2.79378071
110response to peptidoglycan (GO:0032494)2.78531346
111oxidative demethylation (GO:0070989)2.78468377
112formation of translation preinitiation complex (GO:0001731)2.77977161
113translational elongation (GO:0006414)2.77714819
114positive regulation of granulocyte differentiation (GO:0030854)2.77371769
115positive regulation of mitotic sister chromatid separation (GO:1901970)2.75702615
116positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.75702615
117positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.75702615
118regulation of centriole replication (GO:0046599)2.75560728
119regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.73728112
120positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.73434720
121myeloid dendritic cell activation (GO:0001773)2.73087900
122UTP biosynthetic process (GO:0006228)2.73005020
123actin nucleation (GO:0045010)2.72513419
124protein localization to chromosome, centromeric region (GO:0071459)2.72493465
125signal peptide processing (GO:0006465)2.71430747
126rRNA methylation (GO:0031167)2.70988095
127response to interferon-alpha (GO:0035455)2.70967883
128ribosomal large subunit biogenesis (GO:0042273)2.70837185
129mitochondrial respiratory chain complex I assembly (GO:0032981)2.70421771
130NADH dehydrogenase complex assembly (GO:0010257)2.70421771
131mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.70421771
132DNA biosynthetic process (GO:0071897)2.70291023
133carnitine shuttle (GO:0006853)2.69536199
134response to UV-B (GO:0010224)2.68098378
135pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.67181343
136negative thymic T cell selection (GO:0045060)2.66939945
137platelet dense granule organization (GO:0060155)2.66114222
138DNA replication initiation (GO:0006270)2.63854338
139ER overload response (GO:0006983)2.63724587
140apoptotic DNA fragmentation (GO:0006309)2.63632036
141negative regulation of cell aging (GO:0090344)2.63501209
142cellular response to zinc ion (GO:0071294)2.61333866
143mast cell activation involved in immune response (GO:0002279)2.60017476
144mast cell degranulation (GO:0043303)2.60017476
145positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.59912361
146positive regulation of immunoglobulin mediated immune response (GO:0002891)2.59314645
147positive regulation of B cell mediated immunity (GO:0002714)2.59314645
148ribosomal small subunit biogenesis (GO:0042274)2.59119733
149glycine metabolic process (GO:0006544)2.57994479
150purine nucleobase biosynthetic process (GO:0009113)2.57553326
151leukocyte degranulation (GO:0043299)2.56590722
152mitotic recombination (GO:0006312)2.55366713
153autophagic vacuole fusion (GO:0000046)2.54778127
154antigen receptor-mediated signaling pathway (GO:0050851)2.53672591
155UTP metabolic process (GO:0046051)2.53055531
156pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.52583206
157positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.52360931
158T cell lineage commitment (GO:0002360)2.52019250
159plasma lipoprotein particle assembly (GO:0034377)2.51568129
160viral life cycle (GO:0019058)2.51220040
161nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.50664008
162cellular glucuronidation (GO:0052695)2.48842514
163ribosome assembly (GO:0042255)2.48239540
164midgut development (GO:0007494)2.47805997
165regulation of centrosome cycle (GO:0046605)2.45780780
166paraxial mesoderm development (GO:0048339)2.44944633
167membrane budding (GO:0006900)2.43703618
168protein carboxylation (GO:0018214)2.43539713
169peptidyl-glutamic acid carboxylation (GO:0017187)2.43539713
170regulation of response to tumor cell (GO:0002834)2.42747570
171positive regulation of response to tumor cell (GO:0002836)2.42747570
172positive regulation of immune response to tumor cell (GO:0002839)2.42747570
173regulation of immune response to tumor cell (GO:0002837)2.42747570
174histone ubiquitination (GO:0016574)2.41329762
175chaperone-mediated protein complex assembly (GO:0051131)2.38800615
176epoxygenase P450 pathway (GO:0019373)2.38598658
177DNA duplex unwinding (GO:0032508)2.38448377
178erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.37459988
179L-phenylalanine metabolic process (GO:0006558)2.37459988
180primitive streak formation (GO:0090009)2.36986839
181regulation of protein activation cascade (GO:2000257)2.36915010
182rRNA modification (GO:0000154)2.35986426
183erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.35687812
184L-phenylalanine catabolic process (GO:0006559)2.35687812
185embryonic process involved in female pregnancy (GO:0060136)2.35157975
186spermatid nucleus differentiation (GO:0007289)2.30953561
187drug catabolic process (GO:0042737)2.30593449
188exogenous drug catabolic process (GO:0042738)2.30030830
189nucleobase biosynthetic process (GO:0046112)2.29900200
190negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.28722899
191regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.28393897
192regulation of mitotic metaphase/anaphase transition (GO:0030071)2.28393897
193glucuronate metabolic process (GO:0019585)2.26605619
194uronic acid metabolic process (GO:0006063)2.26605619
195short-chain fatty acid metabolic process (GO:0046459)2.26368486
196polyketide metabolic process (GO:0030638)2.26034961
197doxorubicin metabolic process (GO:0044598)2.26034961
198daunorubicin metabolic process (GO:0044597)2.26034961
199regulation of centrosome duplication (GO:0010824)2.25807199

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.38439835
2E2F7_22180533_ChIP-Seq_HELA_Human5.13061405
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.88589344
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.84885970
5AR_21909140_ChIP-Seq_LNCAP_Human3.75332328
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.65325102
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.16105491
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.14441277
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.12733666
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.98753894
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.96330883
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.86251550
13* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.77947263
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.74469377
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.71581129
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.70070622
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.64290372
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.60581495
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.57330837
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.56897879
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.53004525
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.49930227
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.49649749
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48520018
25* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.43264186
26GATA1_22025678_ChIP-Seq_K562_Human2.41179618
27SCL_19346495_ChIP-Seq_HPC-7_Human2.35911139
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.34689650
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.33644356
30* PADI4_21655091_ChIP-ChIP_MCF-7_Human2.27650875
31RUNX_20019798_ChIP-Seq_JUKART_Human2.25715436
32MYCN_18555785_ChIP-Seq_MESCs_Mouse2.24669688
33GABP_17652178_ChIP-ChIP_JURKAT_Human2.22783574
34MYB_21317192_ChIP-Seq_ERMYB_Mouse2.20699890
35IRF8_27001747_Chip-Seq_BMDM_Mouse2.18581104
36MYB_26560356_Chip-Seq_TH2_Human2.16235520
37XRN2_22483619_ChIP-Seq_HELA_Human2.15085709
38TP63_19390658_ChIP-ChIP_HaCaT_Human2.13529384
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.12085721
40CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11306077
41SPI1_23547873_ChIP-Seq_NB4_Human2.11215365
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.10497230
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07520656
44TTF2_22483619_ChIP-Seq_HELA_Human2.07455146
45MYB_26560356_Chip-Seq_TH1_Human2.05148811
46* ERG_20887958_ChIP-Seq_HPC-7_Mouse2.04930124
47EGR1_19374776_ChIP-ChIP_THP-1_Human2.03781542
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.96671304
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.93024670
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.91694843
51VDR_23849224_ChIP-Seq_CD4+_Human1.89990198
52ZNF263_19887448_ChIP-Seq_K562_Human1.84832366
53TP63_17297297_ChIP-ChIP_HaCaT_Human1.84497568
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.84455604
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.84139453
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.81279018
57MYC_18555785_ChIP-Seq_MESCs_Mouse1.80721597
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.80293013
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74863551
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.73379542
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.72270130
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.72183053
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70613297
64* MAF_26560356_Chip-Seq_TH1_Human1.69997055
65* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.69757582
66GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.68914642
67MYC_22102868_ChIP-Seq_BL_Human1.66482849
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64128228
69WT1_19549856_ChIP-ChIP_CCG9911_Human1.59699189
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.58442302
71* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.57316990
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55940766
73ELK1_19687146_ChIP-ChIP_HELA_Human1.55613698
74IRF1_19129219_ChIP-ChIP_H3396_Human1.54584156
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53890586
76EST1_17652178_ChIP-ChIP_JURKAT_Human1.52928766
77FOXP3_21729870_ChIP-Seq_TREG_Human1.52579337
78VDR_21846776_ChIP-Seq_THP-1_Human1.49212621
79SOX17_20123909_ChIP-Seq_XEN_Mouse1.49193439
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47798714
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.46682098
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.46129065
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45981014
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.44821105
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44679854
86BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44373314
87VDR_24763502_ChIP-Seq_THP-1_Human1.42807181
88UTX_26944678_Chip-Seq_JUKART_Human1.42693098
89JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40436136
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39910738
91EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38229272
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.38190150
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36984118
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.33499857
95* EWS_26573619_Chip-Seq_HEK293_Human1.32282004
96PU_27001747_Chip-Seq_BMDM_Mouse1.32076488
97HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30685400
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29387308
99GATA3_27048872_Chip-Seq_THYMUS_Human1.28831314
100DCP1A_22483619_ChIP-Seq_HELA_Human1.27828605
101GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26615888
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26513856
103E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25671535
104SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22210211
105TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.20121804
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20056561
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19659306
108E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17542132
109MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16143590
110CIITA_25753668_ChIP-Seq_RAJI_Human1.16055879
111CHD1_26751641_Chip-Seq_LNCaP_Human1.15333328
112* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15146099
113STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15081884
114GATA3_26560356_Chip-Seq_TH2_Human1.13965447
115E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13851409
116FUS_26573619_Chip-Seq_HEK293_Human1.12993610
117ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12611708
118ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12331191
119KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12128807
120EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12051460
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11459187
122ETS1_20019798_ChIP-Seq_JURKAT_Human1.11257139
123GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09538207
124GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09154108
125CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09109506
126SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09004806
127MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06857217
128* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06087935
129SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03886168
130CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03720278
131NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03589289
132RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03336546
133CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02077946
134HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98899235
135* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98716580
136RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98466474
137KDM5A_27292631_Chip-Seq_BREAST_Human0.98114831
138SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97836107
139CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96650311
140SPI1_23127762_ChIP-Seq_K562_Human0.96273598
141E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95495715
142MAF_26560356_Chip-Seq_TH2_Human0.94705158
143MYC_19030024_ChIP-ChIP_MESCs_Mouse0.94521981
144GABP_19822575_ChIP-Seq_HepG2_Human0.94319479
145PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93745760
146CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93199682
147CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93187846
148FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92739916
149SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90540690
150HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90308620
151KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90282940
152KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90282940
153KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90282940
154CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89967251
155MYC_18940864_ChIP-ChIP_HL60_Human0.89946642
156PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89478149
157ELF5_23300383_ChIP-Seq_T47D_Human0.88876989
158TP53_18474530_ChIP-ChIP_U2OS_Human0.88126473
159RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87389150
160TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87346358
161HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.87004005
162TFEB_21752829_ChIP-Seq_HELA_Human0.85843844
163SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84956297
164PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84142607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition5.69121001
2MP0001835_abnormal_antigen_presentation4.11342861
3MP0005671_abnormal_response_to3.73685739
4MP0002139_abnormal_hepatobiliary_system3.66503763
5MP0010094_abnormal_chromosome_stability3.62654149
6MP0003763_abnormal_thymus_physiology3.34640780
7MP0009785_altered_susceptibility_to3.05864737
8MP0003890_abnormal_embryonic-extraembry3.01481983
9MP0000685_abnormal_immune_system2.98841135
10MP0001800_abnormal_humoral_immune2.96460461
11MP0005000_abnormal_immune_tolerance2.70918648
12MP0002148_abnormal_hypersensitivity_rea2.68401761
13MP0003941_abnormal_skin_development2.66394234
14MP0003724_increased_susceptibility_to2.65940247
15MP0002723_abnormal_immune_serum2.57361637
16MP0002166_altered_tumor_susceptibility2.56329600
17MP0006082_CNS_inflammation2.52467729
18MP0005025_abnormal_response_to2.51167662
19MP0001790_abnormal_immune_system2.50698832
20MP0005387_immune_system_phenotype2.50698832
21MP0002452_abnormal_antigen_presenting2.50091827
22MP0002876_abnormal_thyroid_physiology2.49957610
23MP0002420_abnormal_adaptive_immunity2.47780967
24MP0003436_decreased_susceptibility_to2.45644285
25MP0001819_abnormal_immune_cell2.43978773
26MP0002419_abnormal_innate_immunity2.26442954
27MP0002398_abnormal_bone_marrow2.25867093
28MP0001873_stomach_inflammation2.21480076
29MP0002405_respiratory_system_inflammati2.12729271
30MP0005360_urolithiasis2.12422534
31MP0000462_abnormal_digestive_system2.08298633
32MP0004957_abnormal_blastocyst_morpholog2.05029536
33MP0001849_ear_inflammation2.04631711
34MP0000716_abnormal_immune_system2.03505813
35MP0000689_abnormal_spleen_morphology2.00655860
36MP0003718_maternal_effect1.94898988
37MP0002396_abnormal_hematopoietic_system1.93880064
38MP0002722_abnormal_immune_system1.92041061
39MP0010155_abnormal_intestine_physiology1.91691852
40MP0001666_abnormal_nutrient_absorption1.90482646
41MP0002006_tumorigenesis1.90103103
42MP0005085_abnormal_gallbladder_physiolo1.88907616
43MP0008057_abnormal_DNA_replication1.87678325
44MP0003077_abnormal_cell_cycle1.81055847
45MP0002429_abnormal_blood_cell1.75096393
46MP0005408_hypopigmentation1.74278261
47MP0001845_abnormal_inflammatory_respons1.74071886
48MP0003693_abnormal_embryo_hatching1.73349002
49MP0005464_abnormal_platelet_physiology1.72544597
50MP0000703_abnormal_thymus_morphology1.67122065
51MP0009333_abnormal_splenocyte_physiolog1.65138595
52MP0003385_abnormal_body_wall1.62223878
53MP0008932_abnormal_embryonic_tissue1.60767614
54MP0008469_abnormal_protein_level1.56081922
55MP0004808_abnormal_hematopoietic_stem1.52955043
56MP0000490_abnormal_crypts_of1.50464645
57MP0003011_delayed_dark_adaptation1.48291662
58MP0004510_myositis1.48086549
59MP0003866_abnormal_defecation1.45968682
60MP0003111_abnormal_nucleus_morphology1.45914897
61MP0008058_abnormal_DNA_repair1.44864754
62MP0003252_abnormal_bile_duct1.43429588
63MP0001293_anophthalmia1.42839098
64MP0010030_abnormal_orbit_morphology1.39670998
65MP0000465_gastrointestinal_hemorrhage1.38192899
66MP0009278_abnormal_bone_marrow1.34533911
67MP0002933_joint_inflammation1.32766432
68MP0005075_abnormal_melanosome_morpholog1.32682919
69MP0003186_abnormal_redox_activity1.31850412
70MP0002092_abnormal_eye_morphology1.31583025
71MP0008875_abnormal_xenobiotic_pharmacok1.31073537
72MP0001853_heart_inflammation1.30189716
73MP0006054_spinal_hemorrhage1.28146300
74MP0005174_abnormal_tail_pigmentation1.27514803
75MP0004084_abnormal_cardiac_muscle1.26945511
76MP0005058_abnormal_lysosome_morphology1.25828860
77MP0003868_abnormal_feces_composition1.25797486
78MP0004147_increased_porphyrin_level1.25754075
79MP0009053_abnormal_anal_canal1.25668605
80MP0004233_abnormal_muscle_weight1.22210535
81MP0001730_embryonic_growth_arrest1.22005609
82MP0001697_abnormal_embryo_size1.19474445
83MP0009379_abnormal_foot_pigmentation1.18423086
84MP0009384_cardiac_valve_regurgitation1.18252677
85MP0002138_abnormal_hepatobiliary_system1.16632376
86MP0002084_abnormal_developmental_patter1.15829480
87MP0001764_abnormal_homeostasis1.13999927
88MP0001533_abnormal_skeleton_physiology1.13380959
89MP0002009_preneoplasia1.12262753
90MP0001986_abnormal_taste_sensitivity1.10734853
91MP0005380_embryogenesis_phenotype1.08500231
92MP0001672_abnormal_embryogenesis/_devel1.08500231
93MP0000762_abnormal_tongue_morphology1.08376207
94MP0002233_abnormal_nose_morphology1.08287603
95MP0003172_abnormal_lysosome_physiology1.08171168
96MP0002086_abnormal_extraembryonic_tissu1.07237539
97MP0000343_altered_response_to1.06306328
98MP0000350_abnormal_cell_proliferation1.04179977
99MP0001879_abnormal_lymphatic_vessel1.03591708
100MP0009764_decreased_sensitivity_to1.02354038
101MP0005310_abnormal_salivary_gland1.01634729
102MP0002088_abnormal_embryonic_growth/wei1.00000324
103MP0005584_abnormal_enzyme/coenzyme_acti0.99799022
104MP0001851_eye_inflammation0.99465668
105MP0002638_abnormal_pupillary_reflex0.99432848
106MP0000858_altered_metastatic_potential0.99394623
107MP0002160_abnormal_reproductive_system0.98922802
108MP0001915_intracranial_hemorrhage0.98839065
109MP0003984_embryonic_growth_retardation0.97955164
110MP0009763_increased_sensitivity_to0.97954914
111MP0010352_gastrointestinal_tract_polyps0.96681867
112MP0006036_abnormal_mitochondrial_physio0.96636852
113MP0005197_abnormal_uvea_morphology0.96495751
114MP0005397_hematopoietic_system_phenotyp0.95619864
115MP0001545_abnormal_hematopoietic_system0.95619864
116MP0002080_prenatal_lethality0.94800757
117MP0002697_abnormal_eye_size0.94481392
118MP0002075_abnormal_coat/hair_pigmentati0.94433976
119MP0005367_renal/urinary_system_phenotyp0.94261742
120MP0000516_abnormal_urinary_system0.94261742
121MP0005220_abnormal_exocrine_pancreas0.93507899
122MP0004197_abnormal_fetal_growth/weight/0.92691179
123MP0003828_pulmonary_edema0.92001469
124MP0003937_abnormal_limbs/digits/tail_de0.90746079
125MP0003123_paternal_imprinting0.88106317
126MP0002019_abnormal_tumor_incidence0.87737492
127MP0009672_abnormal_birth_weight0.86900581
128MP0002234_abnormal_pharynx_morphology0.86883959
129MP0002693_abnormal_pancreas_physiology0.86726470
130MP0005551_abnormal_eye_electrophysiolog0.85795539
131MP0005623_abnormal_meninges_morphology0.83984293
132MP0002060_abnormal_skin_morphology0.83545548
133MP0003315_abnormal_perineum_morphology0.83321620
134MP0000372_irregular_coat_pigmentation0.83082512
135MP0000015_abnormal_ear_pigmentation0.81365974
136MP0004272_abnormal_basement_membrane0.80918918
137MP0002085_abnormal_embryonic_tissue0.80034751
138MP0005501_abnormal_skin_physiology0.79922802
139MP0001286_abnormal_eye_development0.79138575
140MP0009697_abnormal_copulation0.78009119
141MP0000609_abnormal_liver_physiology0.76059255
142MP0001340_abnormal_eyelid_morphology0.75796085
143MP0006138_congestive_heart_failure0.75718796
144MP0002132_abnormal_respiratory_system0.75491007
145MP0002998_abnormal_bone_remodeling0.75067659
146MP0005248_abnormal_Harderian_gland0.74933490
147MP0003942_abnormal_urinary_system0.74836175
148MP0003448_altered_tumor_morphology0.74796366
149MP0005391_vision/eye_phenotype0.74633582
150MP0005076_abnormal_cell_differentiation0.72480745
151MP0005319_abnormal_enzyme/_coenzyme0.72374349
152MP0008007_abnormal_cellular_replicative0.72122024
153MP0001727_abnormal_embryo_implantation0.71905023
154MP0003755_abnormal_palate_morphology0.71605747
155MP0004947_skin_inflammation0.71588494
156MP0003705_abnormal_hypodermis_morpholog0.71177224
157MP0005253_abnormal_eye_physiology0.70904558
158MP0001661_extended_life_span0.70643080
159MP0006292_abnormal_olfactory_placode0.70489797
160MP0001186_pigmentation_phenotype0.69414252
161MP0005166_decreased_susceptibility_to0.68774283
162MP0004782_abnormal_surfactant_physiolog0.68135273
163MP0003300_gastrointestinal_ulcer0.67610309
164MP0003699_abnormal_female_reproductive0.67267360
165MP0005395_other_phenotype0.67220767
166MP0001663_abnormal_digestive_system0.65177410
167MP0003303_peritoneal_inflammation0.64970822
168MP0006072_abnormal_retinal_apoptosis0.64784688
169MP0001881_abnormal_mammary_gland0.64633271
170MP0003935_abnormal_craniofacial_develop0.64216881
171MP0009765_abnormal_xenobiotic_induced0.63706830
172MP0000733_abnormal_muscle_development0.63673354
173MP0002095_abnormal_skin_pigmentation0.62655272
174MP0005365_abnormal_bile_salt0.62632282
175MP0003075_altered_response_to0.61967649
176MP0008873_increased_physiological_sensi0.60760754
177MP0000598_abnormal_liver_morphology0.60085331
178MP0003943_abnormal_hepatobiliary_system0.57592069

Predicted human phenotypes

RankGene SetZ-score
1Hypoproteinemia (HP:0003075)7.47143786
2Erythroderma (HP:0001019)4.56661940
3Myositis (HP:0100614)4.56618508
4Eosinophilia (HP:0001880)4.56400332
5Recurrent abscess formation (HP:0002722)4.01559641
6Recurrent bacterial skin infections (HP:0005406)3.72773590
7Ankyloglossia (HP:0010296)3.72167371
8IgM deficiency (HP:0002850)3.57937397
9Recurrent bronchitis (HP:0002837)3.51822663
10T lymphocytopenia (HP:0005403)3.38176433
11Aplasia/Hypoplasia of the thymus (HP:0010515)3.36498032
12Hypothermia (HP:0002045)3.29126448
13Abnormality of T cells (HP:0002843)3.26488795
14Elevated erythrocyte sedimentation rate (HP:0003565)3.22879959
15Panhypogammaglobulinemia (HP:0003139)3.22604760
16Abnormality of T cell number (HP:0011839)3.21351922
17Recurrent viral infections (HP:0004429)3.20143777
18Eczematoid dermatitis (HP:0000976)3.19681923
19Recurrent gram-negative bacterial infections (HP:0005420)3.18400018
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.06402042
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.06402042
22Optic neuritis (HP:0100653)3.05442362
23Retrobulbar optic neuritis (HP:0100654)3.05442362
24Recurrent fungal infections (HP:0002841)3.04098514
25Meningitis (HP:0001287)2.98625143
26Abnormality of T cell physiology (HP:0011840)2.96740990
27Severe combined immunodeficiency (HP:0004430)2.96118331
28Orchitis (HP:0100796)2.95956256
29Encephalitis (HP:0002383)2.94207845
30Hypobetalipoproteinemia (HP:0003563)2.91768540
31Abnormal rod and cone electroretinograms (HP:0008323)2.90615214
32Recurrent sinusitis (HP:0011108)2.89702221
33Thyroiditis (HP:0100646)2.89676123
34Chronic otitis media (HP:0000389)2.88160239
35Reduced antithrombin III activity (HP:0001976)2.86033530
36Chronic sinusitis (HP:0011109)2.84651127
37Spontaneous hematomas (HP:0007420)2.83161324
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.82357385
39Agammaglobulinemia (HP:0004432)2.81780814
40Recurrent skin infections (HP:0001581)2.79192569
41Recurrent cutaneous fungal infections (HP:0011370)2.78521197
42Chronic mucocutaneous candidiasis (HP:0002728)2.78521197
43Hypoplasia of the thymus (HP:0000778)2.74442487
44Aplastic anemia (HP:0001915)2.74100282
45Severe visual impairment (HP:0001141)2.69938963
46Absent rod-and cone-mediated responses on ERG (HP:0007688)2.69834620
47Petechiae (HP:0000967)2.67223009
48Abnormality of complement system (HP:0005339)2.66454355
49IgG deficiency (HP:0004315)2.65775150
50Abnormality of monocarboxylic acid metabolism (HP:0010996)2.61781669
51Deep venous thrombosis (HP:0002625)2.60672348
52Reticulocytopenia (HP:0001896)2.59055191
53Prolonged partial thromboplastin time (HP:0003645)2.58700630
54B lymphocytopenia (HP:0010976)2.58409349
55Abnormality of B cell number (HP:0010975)2.58409349
56Abnormality of the thymus (HP:0000777)2.57638065
57Increased neuronal autofluorescent lipopigment (HP:0002074)2.57081253
58Abnormality of oral frenula (HP:0000190)2.56618482
59Hepatocellular necrosis (HP:0001404)2.54202197
60Prolonged bleeding time (HP:0003010)2.53445911
61Cerebral palsy (HP:0100021)2.53038450
62Combined immunodeficiency (HP:0005387)2.51974339
63Thrombocytosis (HP:0001894)2.45792273
64Type I transferrin isoform profile (HP:0003642)2.45190316
65Hepatic necrosis (HP:0002605)2.43684371
66Abnormal tarsal ossification (HP:0008369)2.42796435
67Abnormal pancreas size (HP:0012094)2.42009526
68Generalized aminoaciduria (HP:0002909)2.40387846
69Chronic obstructive pulmonary disease (HP:0006510)2.39086098
70Obstructive lung disease (HP:0006536)2.39086098
71Pustule (HP:0200039)2.38819081
72Inflammation of the large intestine (HP:0002037)2.37526184
73Vacuolated lymphocytes (HP:0001922)2.37341228
74Papillary thyroid carcinoma (HP:0002895)2.36204975
75Gingival bleeding (HP:0000225)2.35312945
76Chin dimple (HP:0010751)2.35168618
77Epistaxis (HP:0000421)2.33586551
78Papilledema (HP:0001085)2.32204166
79Chronic diarrhea (HP:0002028)2.32142690
80Abnormal number of erythroid precursors (HP:0012131)2.30456099
81Lymphopenia (HP:0001888)2.30104749
82Abnormality of cells of the erythroid lineage (HP:0012130)2.24380709
83Keratoconjunctivitis sicca (HP:0001097)2.23601896
84Gastrointestinal inflammation (HP:0004386)2.20710910
85Vasculitis (HP:0002633)2.20567195
86Stomatitis (HP:0010280)2.18832156
87Agnosia (HP:0010524)2.18831654
88Abnormality of macrophages (HP:0004311)2.18613906
89Septate vagina (HP:0001153)2.17493637
90Abnormality of methionine metabolism (HP:0010901)2.17180904
91Nasal polyposis (HP:0100582)2.16714537
92Interstitial pulmonary disease (HP:0006530)2.15398831
93Purpura (HP:0000979)2.14806882
94Gastrointestinal stroma tumor (HP:0100723)2.14154553
95Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.13782685
96Abnormality of cells of the lymphoid lineage (HP:0012140)2.12774803
97Abnormal foot bone ossification (HP:0010675)2.11749732
98Keratoconjunctivitis (HP:0001096)2.10556000
99Pallor (HP:0000980)2.10405512
100Abnormality of eosinophils (HP:0001879)2.10340770
101Attenuation of retinal blood vessels (HP:0007843)2.10185701
102Mediastinal lymphadenopathy (HP:0100721)2.06439674
103Bronchitis (HP:0012387)2.06427938
104Recurrent pneumonia (HP:0006532)2.05997172
105Pancytopenia (HP:0001876)2.05683244
106Multiple enchondromatosis (HP:0005701)2.05134323
107Congenital stationary night blindness (HP:0007642)2.04878797
108Granulocytopenia (HP:0001913)2.04170370
109Joint swelling (HP:0001386)2.03338372
110Lymphoma (HP:0002665)2.03168087
111Increased cerebral lipofuscin (HP:0011813)2.03148093
112Pulmonary infiltrates (HP:0002113)2.01627551
113Albinism (HP:0001022)2.01533363
114Thoracic kyphosis (HP:0002942)2.00943068
115Abnormal hair whorl (HP:0010721)1.99507210
116Birth length less than 3rd percentile (HP:0003561)1.97607329
117Hypoplasia of the pons (HP:0012110)1.95939675
118Hemoptysis (HP:0002105)1.95916144
119Microcytic anemia (HP:0001935)1.95563895
120Osteomalacia (HP:0002749)1.94010885
121Mitochondrial inheritance (HP:0001427)1.93919191
122Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93663810
123Constricted visual fields (HP:0001133)1.93529077
124Cellulitis (HP:0100658)1.93486135
125Acute lymphatic leukemia (HP:0006721)1.86430788
126Neoplasm of the colon (HP:0100273)1.84677494
127Abnormality of the intrinsic pathway (HP:0010989)1.83729832
128Adrenal hypoplasia (HP:0000835)1.77842406
129Spontaneous abortion (HP:0005268)1.77353042
130Anal stenosis (HP:0002025)1.76456296
131Abnormality of aromatic amino acid family metabolism (HP:0004338)1.74534537
132Pruritus (HP:0000989)1.73284690
133Hyperlipoproteinemia (HP:0010980)1.72732396
134Megaloblastic anemia (HP:0001889)1.72142159
135Conjugated hyperbilirubinemia (HP:0002908)1.71870612
136Bifid uvula (HP:0000193)1.70670718
137Chromsome breakage (HP:0040012)1.70572914
138Gout (HP:0001997)1.70149465
139Thyroid carcinoma (HP:0002890)1.69787773
140Intrahepatic cholestasis (HP:0001406)1.69731736
141Abnormality of the pons (HP:0007361)1.67374379
142Vaginal fistula (HP:0004320)1.65984046
143Hyperammonemia (HP:0001987)1.64659689
144Hypolipoproteinemia (HP:0010981)1.64468666
145Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.63389357
146Termporal pattern (HP:0011008)1.60031641
147Insidious onset (HP:0003587)1.60031641
148Sepsis (HP:0100806)1.59927783
149Acute myeloid leukemia (HP:0004808)1.59457492
150Abnormality of the common coagulation pathway (HP:0010990)1.59434709
151Cellular immunodeficiency (HP:0005374)1.58684911
152Abnormality of pyrimidine metabolism (HP:0004353)1.57956150
153Lower limb hyperreflexia (HP:0002395)1.55430200
154Leukocytosis (HP:0001974)1.55320827
155Abnormality of the nasal septum (HP:0000419)1.55019560
156Overlapping toe (HP:0001845)1.54579693
157Gonadotropin excess (HP:0000837)1.54487411
158Acanthocytosis (HP:0001927)1.54037690
159Preauricular pit (HP:0004467)1.52847285
160Periauricular skin pits (HP:0100277)1.52847285
161Macrocytic anemia (HP:0001972)1.50599685
162Nephritis (HP:0000123)1.49533413
163Abnormality of glutamine family amino acid metabolism (HP:0010902)1.47568789
164Small epiphyses (HP:0010585)1.46891010
165Septo-optic dysplasia (HP:0100842)1.45556548
166Increased mean platelet volume (HP:0011877)1.45429584
167Skin rash (HP:0000988)1.45164139
168Hepatoblastoma (HP:0002884)1.43470788
169Abnormality of aspartate family amino acid metabolism (HP:0010899)1.41288979
170Short tibia (HP:0005736)1.40782629
171Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.40365376
172Abnormal protein N-linked glycosylation (HP:0012347)1.40365376
173Abnormal protein glycosylation (HP:0012346)1.40365376
174Abnormal glycosylation (HP:0012345)1.40365376
175Rectovaginal fistula (HP:0000143)1.39617615
176Rectal fistula (HP:0100590)1.39617615
177Squamous cell carcinoma (HP:0002860)1.38946561
178Premature ovarian failure (HP:0008209)1.36801184
179Methylmalonic acidemia (HP:0002912)1.34812239

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MET3.85811776
2NME23.80800590
3MAP4K13.22707985
4TXK2.87884872
5TEC2.77983018
6IRAK42.77370776
7TYK22.66128904
8TNIK2.62630433
9MAP3K142.51547256
10KIT2.47511758
11NLK2.42078894
12BLK2.41805984
13BMPR1B2.27366676
14MST1R2.23981879
15BTK2.20435631
16CDK122.16111943
17TTK2.09471607
18IKBKE2.08286083
19JAK32.06281583
20FLT31.98784475
21ZAP701.88128327
22CDC71.85656598
23CSF1R1.81612847
24ITK1.70584350
25CDK61.70298370
26EIF2AK11.69592278
27TBK11.68833926
28MAP3K131.67740129
29SYK1.63440827
30ICK1.59725883
31MAPK151.55126787
32CDK191.54886216
33LCK1.54344149
34FES1.50267680
35EIF2AK31.50123813
36TAOK31.50114893
37CDK71.49176642
38TRIM281.47076390
39PIM21.41426034
40PIK3CG1.39652044
41TGFBR11.38807527
42NEK11.37538772
43GRK61.31280046
44JAK11.30002077
45STK101.28231429
46NEK91.28167739
47MAP2K31.26704468
48HCK1.24914843
49VRK11.24672267
50IKBKB1.23683780
51BRD41.23493190
52FGFR41.20314680
53IRAK31.20132029
54EPHA21.20109081
55SCYL21.18597423
56ERBB41.14563554
57PIM11.14337890
58ADRBK21.14211040
59PKN21.12682416
60LYN1.11362918
61TGFBR21.09352040
62LATS11.05774605
63ARAF1.04913066
64CLK11.04652902
65DYRK31.03959793
66SIK31.01438781
67RPS6KB11.00877622
68PLK40.99983815
69MAP3K100.99303325
70CSK0.99121259
71BCR0.98183454
72NEK20.97858665
73PBK0.97308482
74KDR0.94650778
75AURKB0.90941371
76PAK20.90785102
77ZAK0.90634239
78ACVR1B0.87376958
79MAP3K80.87107898
80IRAK10.87079201
81AURKA0.86564887
82FGFR30.86522686
83CHEK20.84680286
84HIPK20.82209983
85PLK10.80468570
86DYRK1B0.79806115
87MUSK0.79592254
88WEE10.79440797
89AKT30.78358582
90RAF10.77932342
91STK240.77522903
92RPS6KB20.77365893
93TLK10.74966606
94ATR0.74871900
95TIE10.74826820
96YES10.74471389
97JAK20.73117112
98CHEK10.70260336
99BRSK20.69939604
100SIK10.69931886
101RPS6KA40.69926936
102MAPK110.69122897
103MAP2K70.68739264
104MAP3K120.66571365
105GRK70.65293478
106MAPKAPK50.65265077
107TNK20.63369761
108BMPR20.62927182
109STK30.62863451
110MAP3K70.62630602
111RIPK40.62191617
112CDK30.61942936
113CDK20.61825721
114RPS6KA50.60975292
115PRKCQ0.60019633
116ATM0.60006190
117MKNK10.59833052
118PDK20.59814166
119EIF2AK20.59496209
120EEF2K0.58911094
121PLK30.58535081
122CDK80.57953702
123CSNK1E0.57800739
124EPHA30.57652139
125TRPM70.56927065
126PDGFRA0.56112151
127CAMKK20.55769431
128MARK30.55718517
129PIK3CA0.54738856
130PASK0.53781469
131MST40.53221642
132BUB10.52959758
133TAF10.52936826
134MAPK40.52898503
135MAP2K60.52498368
136LATS20.51965132
137CAMK10.51951875
138CDK90.51939311
139MTOR0.51480845
140CSNK2A20.50810032
141RPS6KA60.50071143
142NEK60.49628344
143CSNK2A10.48051330
144CDK40.47657363
145MOS0.47593505
146FRK0.46345226
147CDK10.46160330
148SRPK10.45421481
149TYRO30.45349440
150ERN10.43772458
151LRRK20.42604851
152RIPK10.42384933
153STK160.41558212
154OBSCN0.41409669
155MAP3K90.41332395
156RPS6KC10.40201784
157RPS6KL10.40201784
158BCKDK0.38436711
159CSNK1G10.38409526
160PRKG20.37787427
161ABL10.36768580
162ILK0.33188377
163MKNK20.29952424
164EGFR0.29845530
165MELK0.29589586
166MAP3K20.29088972
167CSNK1A1L0.28935714
168GSK3B0.27714225
169MAP3K50.27228804
170AKT20.25668640
171MAP3K40.24323151
172KSR10.24266434
173MYLK0.23124862

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.06460639
2Ribosome_Homo sapiens_hsa030103.53928649
3Protein export_Homo sapiens_hsa030602.78056669
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.44719068
5Antigen processing and presentation_Homo sapiens_hsa046122.41074717
6Measles_Homo sapiens_hsa051622.39303211
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.33538920
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.22482133
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.15355602
10Staphylococcus aureus infection_Homo sapiens_hsa051502.14646006
11DNA replication_Homo sapiens_hsa030302.12763596
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.10881794
13Leishmaniasis_Homo sapiens_hsa051402.08998894
14Non-homologous end-joining_Homo sapiens_hsa034502.07995222
15Hematopoietic cell lineage_Homo sapiens_hsa046402.07791224
16NF-kappa B signaling pathway_Homo sapiens_hsa040642.01755279
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.01627211
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.98213428
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.97197617
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.91254904
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.85591615
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.75052038
23Herpes simplex infection_Homo sapiens_hsa051681.72153745
24B cell receptor signaling pathway_Homo sapiens_hsa046621.71683584
25Folate biosynthesis_Homo sapiens_hsa007901.71450713
26Sulfur relay system_Homo sapiens_hsa041221.71394838
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.70875815
28Cell cycle_Homo sapiens_hsa041101.70464165
29RNA transport_Homo sapiens_hsa030131.68320767
30Propanoate metabolism_Homo sapiens_hsa006401.68306395
31Graft-versus-host disease_Homo sapiens_hsa053321.66221992
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.60467889
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.59496276
34Mismatch repair_Homo sapiens_hsa034301.57052001
35Allograft rejection_Homo sapiens_hsa053301.56417380
36Biosynthesis of amino acids_Homo sapiens_hsa012301.55198021
37Arginine biosynthesis_Homo sapiens_hsa002201.55159564
38Carbon metabolism_Homo sapiens_hsa012001.54274039
39Pyruvate metabolism_Homo sapiens_hsa006201.52428943
40Osteoclast differentiation_Homo sapiens_hsa043801.51783256
41Pyrimidine metabolism_Homo sapiens_hsa002401.48823354
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48248341
43Retinol metabolism_Homo sapiens_hsa008301.48160093
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43929548
45Other glycan degradation_Homo sapiens_hsa005111.43281404
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41067451
47Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38594574
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.36040365
49T cell receptor signaling pathway_Homo sapiens_hsa046601.34908783
50RNA polymerase_Homo sapiens_hsa030201.34823054
51Phenylalanine metabolism_Homo sapiens_hsa003601.31776841
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.31462198
53Jak-STAT signaling pathway_Homo sapiens_hsa046301.24609453
54mRNA surveillance pathway_Homo sapiens_hsa030151.23824439
55Nucleotide excision repair_Homo sapiens_hsa034201.19502164
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17974604
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16900029
58Sulfur metabolism_Homo sapiens_hsa009201.16499684
59Fatty acid degradation_Homo sapiens_hsa000711.15129258
60Hepatitis B_Homo sapiens_hsa051611.15095705
61Proteasome_Homo sapiens_hsa030501.14624933
62Pertussis_Homo sapiens_hsa051331.13749658
63One carbon pool by folate_Homo sapiens_hsa006701.12560774
64Caffeine metabolism_Homo sapiens_hsa002321.11391562
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11084105
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10652308
67Legionellosis_Homo sapiens_hsa051341.07330756
68Base excision repair_Homo sapiens_hsa034101.05640927
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04999967
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.02711566
71Selenocompound metabolism_Homo sapiens_hsa004501.00811695
72Influenza A_Homo sapiens_hsa051640.99887600
73Steroid biosynthesis_Homo sapiens_hsa001000.99757689
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99348855
75Spliceosome_Homo sapiens_hsa030400.98139012
76Fatty acid metabolism_Homo sapiens_hsa012120.97959515
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97015533
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95883359
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95567895
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95166175
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95111945
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94627761
83Tyrosine metabolism_Homo sapiens_hsa003500.93785207
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93656325
85Tuberculosis_Homo sapiens_hsa051520.90249975
86Chemical carcinogenesis_Homo sapiens_hsa052040.89748173
87Fatty acid biosynthesis_Homo sapiens_hsa000610.89375811
88Butanoate metabolism_Homo sapiens_hsa006500.88410516
89Pentose phosphate pathway_Homo sapiens_hsa000300.87896544
90Acute myeloid leukemia_Homo sapiens_hsa052210.87604065
91RNA degradation_Homo sapiens_hsa030180.86187503
92Chemokine signaling pathway_Homo sapiens_hsa040620.85844206
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85207269
94Autoimmune thyroid disease_Homo sapiens_hsa053200.84276446
95Oxidative phosphorylation_Homo sapiens_hsa001900.84115243
96Vitamin B6 metabolism_Homo sapiens_hsa007500.81723650
97Homologous recombination_Homo sapiens_hsa034400.80476927
98Parkinsons disease_Homo sapiens_hsa050120.76651109
99Purine metabolism_Homo sapiens_hsa002300.75636998
100Rheumatoid arthritis_Homo sapiens_hsa053230.75294458
101Apoptosis_Homo sapiens_hsa042100.75111781
102Starch and sucrose metabolism_Homo sapiens_hsa005000.74943870
103Lysosome_Homo sapiens_hsa041420.73342306
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71188597
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67827578
106Complement and coagulation cascades_Homo sapiens_hsa046100.66909458
107p53 signaling pathway_Homo sapiens_hsa041150.66771853
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.66342818
109Asthma_Homo sapiens_hsa053100.65999167
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65339311
111Epstein-Barr virus infection_Homo sapiens_hsa051690.64350880
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63912767
113Toxoplasmosis_Homo sapiens_hsa051450.63807595
114Systemic lupus erythematosus_Homo sapiens_hsa053220.62875929
115TGF-beta signaling pathway_Homo sapiens_hsa043500.60666062
116Fatty acid elongation_Homo sapiens_hsa000620.60505510
117Arginine and proline metabolism_Homo sapiens_hsa003300.59239198
118Alzheimers disease_Homo sapiens_hsa050100.57773375
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56657739
120Peroxisome_Homo sapiens_hsa041460.56237782
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55893473
122Thyroid cancer_Homo sapiens_hsa052160.55097537
123Malaria_Homo sapiens_hsa051440.54147384
124Vitamin digestion and absorption_Homo sapiens_hsa049770.53311751
125Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52761697
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.52726429
127Viral myocarditis_Homo sapiens_hsa054160.51930097
128Huntingtons disease_Homo sapiens_hsa050160.50659159
129ABC transporters_Homo sapiens_hsa020100.49947815
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49776855
131Renin-angiotensin system_Homo sapiens_hsa046140.47945030
132Circadian rhythm_Homo sapiens_hsa047100.47703470
133FoxO signaling pathway_Homo sapiens_hsa040680.47478812
134Platelet activation_Homo sapiens_hsa046110.46589407
135Shigellosis_Homo sapiens_hsa051310.46515413
136Glutathione metabolism_Homo sapiens_hsa004800.44290397
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.44201377
138HTLV-I infection_Homo sapiens_hsa051660.43188554
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42492966
140N-Glycan biosynthesis_Homo sapiens_hsa005100.41856259
141Fat digestion and absorption_Homo sapiens_hsa049750.41638327
142Basal transcription factors_Homo sapiens_hsa030220.40615735
143TNF signaling pathway_Homo sapiens_hsa046680.40487934
144Pancreatic cancer_Homo sapiens_hsa052120.40454494
145PPAR signaling pathway_Homo sapiens_hsa033200.39395186
146Type I diabetes mellitus_Homo sapiens_hsa049400.38208569
147Lysine degradation_Homo sapiens_hsa003100.37098886
148Oocyte meiosis_Homo sapiens_hsa041140.36695167
149Arachidonic acid metabolism_Homo sapiens_hsa005900.36554417
150Galactose metabolism_Homo sapiens_hsa000520.35273109
151Small cell lung cancer_Homo sapiens_hsa052220.34245191
152Phagosome_Homo sapiens_hsa041450.33227856
153Fanconi anemia pathway_Homo sapiens_hsa034600.32054235
154Viral carcinogenesis_Homo sapiens_hsa052030.31240971
155Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30522756
156Metabolic pathways_Homo sapiens_hsa011000.29590214
157Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29462015

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