TIGD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)6.93259939
2modulation by symbiont of host defense response (GO:0052031)6.93259939
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.93259939
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.93259939
5positive regulation by organism of defense response of other organism involved in symbiotic interact6.93259939
6modulation by symbiont of host immune response (GO:0052553)6.93259939
7negative regulation of cell killing (GO:0031342)6.70864167
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.70864167
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.54888475
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.49796359
11antigen processing and presentation of endogenous antigen (GO:0019883)5.34106611
12macrophage activation involved in immune response (GO:0002281)5.19255531
13positive regulation of gamma-delta T cell activation (GO:0046645)5.08030571
14neutrophil activation involved in immune response (GO:0002283)5.01077400
15detection of other organism (GO:0098543)4.93518864
16leukocyte migration involved in inflammatory response (GO:0002523)4.81238107
17respiratory burst (GO:0045730)4.80475449
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.74550811
19detection of molecule of bacterial origin (GO:0032490)4.70967384
20regulation of B cell receptor signaling pathway (GO:0050855)4.70191972
21detection of bacterium (GO:0016045)4.67074537
22neutrophil activation (GO:0042119)4.62965537
23neutrophil mediated immunity (GO:0002446)4.62040344
24regulation of interferon-beta biosynthetic process (GO:0045357)4.56456354
25response to peptidoglycan (GO:0032494)4.51195969
26response to host immune response (GO:0052572)4.50809010
27response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.50809010
28negative regulation of lymphocyte mediated immunity (GO:0002707)4.50197509
29positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.47011367
30detection of external biotic stimulus (GO:0098581)4.43460913
31response to interleukin-15 (GO:0070672)4.38220627
32microglial cell activation (GO:0001774)4.27314618
33cellular extravasation (GO:0045123)4.15918276
34cellular response to interleukin-15 (GO:0071350)4.13171957
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.12240941
36granulocyte activation (GO:0036230)4.08740993
37negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.07578411
38response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.03850576
39response to host (GO:0075136)4.03850576
40response to host defenses (GO:0052200)4.03850576
41leukocyte aggregation (GO:0070486)3.99144535
42negative regulation of leukocyte mediated immunity (GO:0002704)3.85318351
43negative regulation of interleukin-12 production (GO:0032695)3.83313069
44detection of biotic stimulus (GO:0009595)3.81707445
45myeloid leukocyte mediated immunity (GO:0002444)3.77108768
46regulation of mast cell degranulation (GO:0043304)3.76164062
47macrophage activation (GO:0042116)3.70687734
48microtubule depolymerization (GO:0007019)3.58307672
49centriole assembly (GO:0098534)3.57242902
50myeloid cell activation involved in immune response (GO:0002275)3.55353978
51regulation of timing of cell differentiation (GO:0048505)3.53016266
52regulation of mast cell activation involved in immune response (GO:0033006)3.52079579
53regulation of gamma-delta T cell activation (GO:0046643)3.50715744
54limb bud formation (GO:0060174)3.49793198
55positive regulation of mast cell activation (GO:0033005)3.49178117
56axon ensheathment in central nervous system (GO:0032291)3.47175363
57central nervous system myelination (GO:0022010)3.47175363
58negative regulation of phagocytosis (GO:0050765)3.46161383
59keratinocyte development (GO:0003334)3.45556897
60mesenchymal cell differentiation involved in renal system development (GO:2001012)3.44666403
61mesenchymal cell differentiation involved in kidney development (GO:0072161)3.44666403
62regulation of myeloid leukocyte mediated immunity (GO:0002886)3.43518227
63B cell receptor signaling pathway (GO:0050853)3.43427281
64negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.38995908
65negative regulation of T cell mediated immunity (GO:0002710)3.38840385
66developmental pigmentation (GO:0048066)3.35086913
67positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.33717837
68immunoglobulin mediated immune response (GO:0016064)3.31824767
69regulation of leukocyte degranulation (GO:0043300)3.29300532
70regulation of mast cell activation (GO:0033003)3.28867112
71DNA deamination (GO:0045006)3.27959564
72regulation of development, heterochronic (GO:0040034)3.23834506
73regulation of regulated secretory pathway (GO:1903305)3.20267146
74negative regulation of DNA-dependent DNA replication (GO:2000104)3.18578475
75presynaptic membrane assembly (GO:0097105)3.17695981
76presynaptic membrane organization (GO:0097090)3.17611952
77female gonad development (GO:0008585)3.16460409
78response to muramyl dipeptide (GO:0032495)3.16210897
79regulation of nuclear cell cycle DNA replication (GO:0033262)3.14667630
80negative regulation of myoblast differentiation (GO:0045662)3.12624918
81leukocyte degranulation (GO:0043299)3.08944620
82defense response to protozoan (GO:0042832)3.07388687
83production of molecular mediator involved in inflammatory response (GO:0002532)3.05826420
84DNA ligation (GO:0006266)2.98446959
85regulation of gamma-delta T cell differentiation (GO:0045586)2.97125879
86negative regulation of execution phase of apoptosis (GO:1900118)2.96594447
87negative regulation of interleukin-6 production (GO:0032715)2.94310569
88positive regulation of T cell mediated cytotoxicity (GO:0001916)2.91955202
89positive regulation of mast cell activation involved in immune response (GO:0033008)2.91626819
90positive regulation of mast cell degranulation (GO:0043306)2.91626819
91negative regulation of innate immune response (GO:0045824)2.91404016
92activated T cell proliferation (GO:0050798)2.90989991
93regulation of T-helper 2 cell differentiation (GO:0045628)2.90923600
94negative regulation of glycoprotein biosynthetic process (GO:0010561)2.90895729
95positive regulation of protein homodimerization activity (GO:0090073)2.90532058
96regulation of T cell mediated cytotoxicity (GO:0001914)2.89961389
97regulation of T cell tolerance induction (GO:0002664)2.87135682
98antigen processing and presentation via MHC class Ib (GO:0002475)2.85610544
99ceramide catabolic process (GO:0046514)2.84306442
100positive regulation of regulated secretory pathway (GO:1903307)2.84206319
101regulation of B cell differentiation (GO:0045577)2.83518855
102protein-cofactor linkage (GO:0018065)2.83335189
103negative regulation of cAMP-mediated signaling (GO:0043951)2.82486991
104negative regulation of type 2 immune response (GO:0002829)2.81927355
105regulation of natural killer cell mediated immunity (GO:0002715)2.81888358
106regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.81888358
107dendritic cell migration (GO:0036336)2.81583342
108germinal center formation (GO:0002467)2.80644235
109histone H2B ubiquitination (GO:0033523)2.80232879
110superoxide anion generation (GO:0042554)2.79538505
111regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.77491574
112transcription elongation from RNA polymerase III promoter (GO:0006385)2.77394001
113termination of RNA polymerase III transcription (GO:0006386)2.77394001
114forebrain neuron differentiation (GO:0021879)2.77124512
115positive regulation of cellular amide metabolic process (GO:0034250)2.76926494
116retina layer formation (GO:0010842)2.76047967
117negative regulation of telomere maintenance (GO:0032205)2.75789366
118negative regulation of toll-like receptor signaling pathway (GO:0034122)2.74052310
119preassembly of GPI anchor in ER membrane (GO:0016254)2.73499231
120adenosine metabolic process (GO:0046085)2.71295476
121regulation of tolerance induction (GO:0002643)2.70746247
122regulation of somitogenesis (GO:0014807)2.70669484
123centriole replication (GO:0007099)2.69471748
124cell proliferation in forebrain (GO:0021846)2.69220764
125actin filament polymerization (GO:0030041)2.68733982
126long-chain fatty acid biosynthetic process (GO:0042759)2.68430323
127oligosaccharide catabolic process (GO:0009313)2.68326431
128regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.67133509
129positive regulation of toll-like receptor signaling pathway (GO:0034123)2.67018328
130myeloid leukocyte activation (GO:0002274)2.66858986
131nucleotide transmembrane transport (GO:1901679)2.66813945
132disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.66504516
133killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.66504516
134righting reflex (GO:0060013)2.65261553
135glycosphingolipid catabolic process (GO:0046479)2.64885665
136positive regulation of protein homooligomerization (GO:0032464)2.64434516
137cranial nerve morphogenesis (GO:0021602)2.63910590
138dendritic cell chemotaxis (GO:0002407)2.63551322
139neuron cell-cell adhesion (GO:0007158)2.62778768
140amino sugar catabolic process (GO:0046348)2.61827378
141left/right axis specification (GO:0070986)2.61695465
142regulation of chromatin binding (GO:0035561)2.61481099
143negative thymic T cell selection (GO:0045060)2.61337577
144regulation of cellular amide metabolic process (GO:0034248)2.61045630
145kinetochore assembly (GO:0051382)2.59083025
146GPI anchor biosynthetic process (GO:0006506)2.59035182
147cell differentiation involved in metanephros development (GO:0072202)2.58624749
148positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.58572752
149DNA integration (GO:0015074)2.56164375
150DNA strand renaturation (GO:0000733)2.54874851
151protein heterotetramerization (GO:0051290)2.54618789
152positive regulation of uterine smooth muscle contraction (GO:0070474)2.50873289
153spinal cord association neuron differentiation (GO:0021527)2.48529572
154polyol transport (GO:0015791)2.47214202
155RNA destabilization (GO:0050779)2.47025998
156organ growth (GO:0035265)2.45990859
157postsynaptic membrane organization (GO:0001941)2.44435917
158proteasome assembly (GO:0043248)2.42556340
159startle response (GO:0001964)2.42465843
160tRNA methylation (GO:0030488)2.41742589
161mesonephros development (GO:0001823)2.41113413
162G-protein coupled receptor internalization (GO:0002031)2.40864684
163regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.40359129
164microtubule polymerization or depolymerization (GO:0031109)2.38889414
165energy homeostasis (GO:0097009)2.37797698
166sympathetic nervous system development (GO:0048485)2.36880432
167negative regulation of transcription by competitive promoter binding (GO:0010944)2.36609435
168positive regulation of action potential (GO:0045760)2.36346272
169lymphoid progenitor cell differentiation (GO:0002320)2.35886069
170negative regulation of keratinocyte proliferation (GO:0010839)2.34941343
171regulation of double-strand break repair via homologous recombination (GO:0010569)2.34623958
172cell differentiation in spinal cord (GO:0021515)2.34573923
173regulation of pigment cell differentiation (GO:0050932)2.34518846
174cornea development in camera-type eye (GO:0061303)2.34429210
175omega-hydroxylase P450 pathway (GO:0097267)2.33226640
176regulation of male gonad development (GO:2000018)2.32808040
177glycolipid catabolic process (GO:0019377)2.32768900
178GPI anchor metabolic process (GO:0006505)2.32571903
179spinal cord motor neuron differentiation (GO:0021522)2.31847750
180cerebral cortex radially oriented cell migration (GO:0021799)2.30889931
181tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.30437348
182RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.30437348
183DNA damage response, detection of DNA damage (GO:0042769)2.28889029
184synapsis (GO:0007129)2.28346356
185negative regulation of homotypic cell-cell adhesion (GO:0034111)2.27868550
186histone H4-K12 acetylation (GO:0043983)2.26831774
187generation of neurons (GO:0048699)2.25805678
188reflex (GO:0060004)2.24247614
189cilium assembly (GO:0042384)2.23933192
190replicative senescence (GO:0090399)2.23459939
191axonemal dynein complex assembly (GO:0070286)2.23429827
192male sex determination (GO:0030238)2.23413898
193eye photoreceptor cell differentiation (GO:0001754)2.22931445
194photoreceptor cell differentiation (GO:0046530)2.22931445
195regulation of platelet aggregation (GO:0090330)2.22557996
196regulation of rhodopsin mediated signaling pathway (GO:0022400)2.21857214
197axoneme assembly (GO:0035082)2.21610038
198photoreceptor cell maintenance (GO:0045494)2.20616332
199dentate gyrus development (GO:0021542)2.19997156
200inner ear receptor stereocilium organization (GO:0060122)2.18991998

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.43080595
2VDR_21846776_ChIP-Seq_THP-1_Human3.59354348
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.52772072
4GBX2_23144817_ChIP-Seq_PC3_Human3.47596067
5EZH2_22144423_ChIP-Seq_EOC_Human3.46063168
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.33437933
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.17027075
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.11763867
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.05163357
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.86152399
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.77707478
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.71928103
13MYC_22102868_ChIP-Seq_BL_Human2.71822020
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.63385947
15* SPI1_23547873_ChIP-Seq_NB4_Human2.54916741
16MAF_26560356_Chip-Seq_TH1_Human2.50059434
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.49759423
18VDR_24763502_ChIP-Seq_THP-1_Human2.49193487
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.47937297
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.47820397
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47031784
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.43903633
23TP63_19390658_ChIP-ChIP_HaCaT_Human2.43288761
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.42295582
25PCGF2_27294783_Chip-Seq_ESCs_Mouse2.41298761
26* UTX_26944678_Chip-Seq_JUKART_Human2.39729541
27KDM2B_26808549_Chip-Seq_DND41_Human2.35405850
28* SPI1_23127762_ChIP-Seq_K562_Human2.32895057
29JARID2_20064375_ChIP-Seq_MESCs_Mouse2.28801098
30RUNX1_22412390_ChIP-Seq_EML_Mouse2.26049527
31EZH2_27304074_Chip-Seq_ESCs_Mouse2.25110770
32FLI1_27457419_Chip-Seq_LIVER_Mouse2.24200553
33TAF15_26573619_Chip-Seq_HEK293_Human2.22852267
34TCF7_22412390_ChIP-Seq_EML_Mouse2.22705752
35* MAF_26560356_Chip-Seq_TH2_Human2.20044737
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.19934813
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.18106413
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.16445713
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16315039
40EED_16625203_ChIP-ChIP_MESCs_Mouse2.14885364
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.13797318
42IRF8_27001747_Chip-Seq_BMDM_Mouse2.11481520
43PCGF2_27294783_Chip-Seq_NPCs_Mouse2.08866214
44SUZ12_27294783_Chip-Seq_NPCs_Mouse2.08525260
45POU5F1_16153702_ChIP-ChIP_HESCs_Human2.04391935
46RNF2_27304074_Chip-Seq_NSC_Mouse2.02661578
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02311451
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.99308664
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.99091725
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91294059
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87187677
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86991049
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86620771
54LXR_22292898_ChIP-Seq_THP-1_Human1.83403610
55RUNX_20019798_ChIP-Seq_JUKART_Human1.81134466
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.80975691
57* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.80185927
58KDM2B_26808549_Chip-Seq_JURKAT_Human1.80164565
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.80006086
60VDR_22108803_ChIP-Seq_LS180_Human1.76246523
61IGF1R_20145208_ChIP-Seq_DFB_Human1.75284124
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74359138
63SCL_19346495_ChIP-Seq_HPC-7_Human1.72429591
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.72296797
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71451734
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.71249948
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.69958694
68* BCL6_27268052_Chip-Seq_Bcells_Human1.69663412
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69134791
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.68892386
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67447875
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67089421
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.67042831
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65453337
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.65411792
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.64678575
77SUZ12_18555785_Chip-Seq_ESCs_Mouse1.63136800
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.62547256
79P300_19829295_ChIP-Seq_ESCs_Human1.62316515
80EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.61336061
81MYB_26560356_Chip-Seq_TH1_Human1.60818486
82IRF1_19129219_ChIP-ChIP_H3396_Human1.60764035
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60558766
84SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60474609
85STAT3_18555785_Chip-Seq_ESCs_Mouse1.59524759
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.59114362
87FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58304307
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57905433
89NMYC_18555785_Chip-Seq_ESCs_Mouse1.56108732
90EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55675448
91RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55675448
92P53_22387025_ChIP-Seq_ESCs_Mouse1.55374780
93* MYB_26560356_Chip-Seq_TH2_Human1.54863976
94CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54796956
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53666528
96PU.1_20513432_ChIP-Seq_Bcells_Mouse1.53062108
97RNF2_27304074_Chip-Seq_ESCs_Mouse1.52286412
98P300_18555785_Chip-Seq_ESCs_Mouse1.51806880
99SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50682570
100* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.50339198
101CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49508534
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48013966
103RUNX1_27457419_Chip-Seq_LIVER_Mouse1.47948924
104SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46893661
105* P68_20966046_ChIP-Seq_HELA_Human1.46608628
106GATA3_27048872_Chip-Seq_THYMUS_Human1.44838348
107CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43734047
108CMYC_18555785_Chip-Seq_ESCs_Mouse1.43650597
109CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43122511
110ZFX_18555785_Chip-Seq_ESCs_Mouse1.42832004
111DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42699880
112CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42119836
113KLF4_18555785_Chip-Seq_ESCs_Mouse1.40676649
114OCT4_18555785_Chip-Seq_ESCs_Mouse1.40448964
115* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40448338
116LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40023883
117ELK3_25401928_ChIP-Seq_HUVEC_Human1.39825422
118BCOR_27268052_Chip-Seq_Bcells_Human1.38641325
119PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38468662
120PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37229748
121EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36551092
122STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35757578
123SOX2_18555785_Chip-Seq_ESCs_Mouse1.35729235
124SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35112317
125FUS_26573619_Chip-Seq_HEK293_Human1.34699113
126IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33675581
127SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33402989
128SA1_27219007_Chip-Seq_ERYTHROID_Human1.32250457
129ESRRB_18555785_Chip-Seq_ESCs_Mouse1.31859631
130ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31641751
131PU1_27457419_Chip-Seq_LIVER_Mouse1.29716163
132PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28259679
133ELF1_20517297_ChIP-Seq_JURKAT_Human1.27620908
134SMAD1_18555785_Chip-Seq_ESCs_Mouse1.27370094
135KDM2B_26808549_Chip-Seq_K562_Human1.27177963
136SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26468055
137GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26069729
138ER_23166858_ChIP-Seq_MCF-7_Human1.25803126
139EWS_26573619_Chip-Seq_HEK293_Human1.25549930
140TAL1_26923725_Chip-Seq_HPCs_Mouse1.25384246
141KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24859403
142GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24437638
143CTCF_18555785_Chip-Seq_ESCs_Mouse1.24375887
144GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23640770
145SMAD3_21741376_ChIP-Seq_EPCs_Human1.23089158
146SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.23080254
147CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20390711
148STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.18163942
149SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18160505
150CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17177639
151CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17161701
152SMC4_20622854_ChIP-Seq_HELA_Human1.16130733
153ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15155681
154CRX_20693478_ChIP-Seq_RETINA_Mouse1.14812584
155UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14749582
156RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13767963
157OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13569051
158PHF8_20622854_ChIP-Seq_HELA_Human1.13204626
159EGR1_19374776_ChIP-ChIP_THP-1_Human1.13049234
160CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12897454
161POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12587102
162TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12587102
163LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10536609
164ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09657610
165* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09350851
166SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08785543
167CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08401651
168SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08266843
169* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.08192775
170SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07769086
171TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07634254
172LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06722800
173TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06453900
174SMAD_19615063_ChIP-ChIP_OVARY_Human1.06198179
175MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06009519
176E2F1_20622854_ChIP-Seq_HELA_Human1.05494040
177REST_21632747_ChIP-Seq_MESCs_Mouse1.05488296
178CIITA_25753668_ChIP-Seq_RAJI_Human1.05160714
179CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04775451
180HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04661122
181OCT4_19829295_ChIP-Seq_ESCs_Human1.03498991
182RUNX2_22187159_ChIP-Seq_PCA_Human1.03208884
183NOTCH1_21737748_ChIP-Seq_TLL_Human1.03032726
184SMAD4_21799915_ChIP-Seq_A2780_Human1.02623906
185MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01541983
186RACK7_27058665_Chip-Seq_MCF-7_Human0.99881295
187EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99440978
188YY1_22570637_ChIP-Seq_MALME-3M_Human0.99421978
189AR_21572438_ChIP-Seq_LNCaP_Human0.98524063
190SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98403145
191TET1_21451524_ChIP-Seq_MESCs_Mouse0.95378946
192P300_27268052_Chip-Seq_Bcells_Human0.95183933
193GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94376418
194P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94269074
195PIAS1_25552417_ChIP-Seq_VCAP_Human0.93491710
196IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93413168

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.19265129
2MP0001188_hyperpigmentation3.95709200
3MP0002102_abnormal_ear_morphology3.63923735
4MP0003303_peritoneal_inflammation3.55298530
5MP0006292_abnormal_olfactory_placode3.45876325
6MP0000566_synostosis3.43199322
7MP0003136_yellow_coat_color3.25344506
8MP0002653_abnormal_ependyma_morphology3.16810170
9MP0004381_abnormal_hair_follicle3.04213687
10MP0002419_abnormal_innate_immunity2.75659564
11MP0001800_abnormal_humoral_immune2.66657756
12MP0001835_abnormal_antigen_presentation2.66566587
13MP0003191_abnormal_cellular_cholesterol2.66324645
14MP0005025_abnormal_response_to2.52161980
15MP0005387_immune_system_phenotype2.40202213
16MP0001790_abnormal_immune_system2.40202213
17MP0005671_abnormal_response_to2.39923282
18MP0003880_abnormal_central_pattern2.38919585
19MP0005409_darkened_coat_color2.35395815
20MP0005423_abnormal_somatic_nervous2.34801165
21MP0005000_abnormal_immune_tolerance2.34017907
22MP0005645_abnormal_hypothalamus_physiol2.33116495
23MP0002723_abnormal_immune_serum2.31564309
24MP0002420_abnormal_adaptive_immunity2.29101530
25MP0001819_abnormal_immune_cell2.25984744
26MP0005171_absent_coat_pigmentation2.24497218
27MP0001986_abnormal_taste_sensitivity2.23756218
28MP0000685_abnormal_immune_system2.16301078
29MP0009785_altered_susceptibility_to2.10425232
30MP0002452_abnormal_antigen_presenting2.08103316
31MP0002277_abnormal_respiratory_mucosa2.05992705
32MP0004742_abnormal_vestibular_system2.03887346
33MP0003183_abnormal_peptide_metabolism2.02885179
34MP0006082_CNS_inflammation1.97761016
35MP0006276_abnormal_autonomic_nervous1.89835030
36MP0000015_abnormal_ear_pigmentation1.89571320
37MP0008058_abnormal_DNA_repair1.86892732
38MP0008995_early_reproductive_senescence1.82621831
39MP0003787_abnormal_imprinting1.79976487
40MP0003938_abnormal_ear_development1.78660384
41MP0002398_abnormal_bone_marrow1.74654280
42MP0001533_abnormal_skeleton_physiology1.73947644
43MP0000465_gastrointestinal_hemorrhage1.73781680
44MP0003941_abnormal_skin_development1.73777113
45MP0009278_abnormal_bone_marrow1.71229969
46MP0000716_abnormal_immune_system1.70742640
47MP0003866_abnormal_defecation1.68615031
48MP0005174_abnormal_tail_pigmentation1.64075325
49MP0008260_abnormal_autophagy1.63854709
50MP0002405_respiratory_system_inflammati1.63826409
51MP0000026_abnormal_inner_ear1.60211944
52MP0001486_abnormal_startle_reflex1.54038416
53MP0003315_abnormal_perineum_morphology1.51619472
54MP0001529_abnormal_vocalization1.50334514
55MP0003300_gastrointestinal_ulcer1.48763471
56MP0001984_abnormal_olfaction1.48528134
57MP0002638_abnormal_pupillary_reflex1.46451647
58MP0002249_abnormal_larynx_morphology1.46083768
59MP0005464_abnormal_platelet_physiology1.45667942
60MP0000049_abnormal_middle_ear1.45387624
61MP0000689_abnormal_spleen_morphology1.45124066
62MP0002148_abnormal_hypersensitivity_rea1.45019382
63MP0003763_abnormal_thymus_physiology1.43310788
64MP0008789_abnormal_olfactory_epithelium1.43122850
65MP0000778_abnormal_nervous_system1.42298051
66MP0002722_abnormal_immune_system1.41884375
67MP0003172_abnormal_lysosome_physiology1.39647171
68MP0002751_abnormal_autonomic_nervous1.36800026
69MP0003786_premature_aging1.34390717
70MP0002396_abnormal_hematopoietic_system1.34317533
71MP0005075_abnormal_melanosome_morpholog1.33695194
72MP0003221_abnormal_cardiomyocyte_apopto1.33512526
73MP0002429_abnormal_blood_cell1.32858947
74MP0000383_abnormal_hair_follicle1.32740561
75MP0006072_abnormal_retinal_apoptosis1.32488361
76MP0005379_endocrine/exocrine_gland_phen1.31956373
77MP0001845_abnormal_inflammatory_respons1.31712712
78MP0004142_abnormal_muscle_tone1.31315072
79MP0000703_abnormal_thymus_morphology1.29450656
80MP0003718_maternal_effect1.29261349
81MP0005394_taste/olfaction_phenotype1.27168955
82MP0005499_abnormal_olfactory_system1.27168955
83MP0001485_abnormal_pinna_reflex1.25927242
84MP0008961_abnormal_basal_metabolism1.25314769
85MP0000631_abnormal_neuroendocrine_gland1.25193683
86MP0002938_white_spotting1.25009546
87MP0005646_abnormal_pituitary_gland1.23731678
88MP0009764_decreased_sensitivity_to1.21513038
89MP0000490_abnormal_crypts_of1.21308283
90MP0010386_abnormal_urinary_bladder1.20308345
91MP0010155_abnormal_intestine_physiology1.19759544
92MP0001963_abnormal_hearing_physiology1.18991792
93MP0003828_pulmonary_edema1.17318537
94MP0005551_abnormal_eye_electrophysiolog1.16367054
95MP0003111_abnormal_nucleus_morphology1.15132328
96MP0002928_abnormal_bile_duct1.13852515
97MP0008469_abnormal_protein_level1.13405478
98MP0002160_abnormal_reproductive_system1.12965306
99MP0005377_hearing/vestibular/ear_phenot1.12668872
100MP0003878_abnormal_ear_physiology1.12668872
101MP0008877_abnormal_DNA_methylation1.12151097
102MP0004133_heterotaxia1.11416011
103MP0002132_abnormal_respiratory_system1.10155527
104MP0002752_abnormal_somatic_nervous1.08615693
105MP0009333_abnormal_splenocyte_physiolog1.08252177
106MP0002184_abnormal_innervation1.07152606
107MP0002876_abnormal_thyroid_physiology1.06056270
108MP0003690_abnormal_glial_cell1.05272898
109MP0001905_abnormal_dopamine_level1.04789314
110MP0005253_abnormal_eye_physiology1.04707237
111MP0005248_abnormal_Harderian_gland1.04690754
112MP0002095_abnormal_skin_pigmentation1.04254279
113MP0003937_abnormal_limbs/digits/tail_de1.02670877
114MP0005310_abnormal_salivary_gland1.01211462
115MP0002163_abnormal_gland_morphology1.00791933
116MP0009046_muscle_twitch1.00237972
117MP0005451_abnormal_body_composition0.99152978
118MP0003329_amyloid_beta_deposits0.98804511
119MP0002557_abnormal_social/conspecific_i0.98064563
120MP0009379_abnormal_foot_pigmentation0.97467691
121MP0008057_abnormal_DNA_replication0.97003208
122MP0000613_abnormal_salivary_gland0.95523977
123MP0002272_abnormal_nervous_system0.95412787
124MP0004130_abnormal_muscle_cell0.95184710
125MP0004858_abnormal_nervous_system0.94239972
126MP0009745_abnormal_behavioral_response0.93887468
127MP0004883_abnormal_blood_vessel0.93772047
128MP0002735_abnormal_chemical_nociception0.92002677
129MP0003724_increased_susceptibility_to0.91705444
130MP0002067_abnormal_sensory_capabilities0.89579930
131MP0002233_abnormal_nose_morphology0.88687920
132MP0001851_eye_inflammation0.88241095
133MP0004947_skin_inflammation0.88045882
134MP0002177_abnormal_outer_ear0.87795784
135MP0003646_muscle_fatigue0.87771060
136MP0001727_abnormal_embryo_implantation0.87765434
137MP0000372_irregular_coat_pigmentation0.87741978
138MP0001286_abnormal_eye_development0.87244626
139MP0000762_abnormal_tongue_morphology0.87196128
140MP0001919_abnormal_reproductive_system0.87135292
141MP0002098_abnormal_vibrissa_morphology0.86856637
142MP0000647_abnormal_sebaceous_gland0.86842383
143MP0003755_abnormal_palate_morphology0.86628911
144MP0000858_altered_metastatic_potential0.86572529
145MP0005389_reproductive_system_phenotype0.84468284
146MP0001346_abnormal_lacrimal_gland0.83440746
147MP0008874_decreased_physiological_sensi0.83170309
148MP0003121_genomic_imprinting0.83046359
149MP0009250_abnormal_appendicular_skeleto0.82766905
150MP0002572_abnormal_emotion/affect_behav0.81734435
151MP0001186_pigmentation_phenotype0.81239836
152MP0001545_abnormal_hematopoietic_system0.81162759
153MP0005397_hematopoietic_system_phenotyp0.81162759
154MP0003122_maternal_imprinting0.79255512
155MP0003385_abnormal_body_wall0.78849829
156MP0001968_abnormal_touch/_nociception0.77498079
157MP0002734_abnormal_mechanical_nocicepti0.76873240
158MP0010094_abnormal_chromosome_stability0.75775332
159MP0004270_analgesia0.75189788
160MP0002116_abnormal_craniofacial_bone0.74304095
161MP0008932_abnormal_embryonic_tissue0.74010362
162MP0004811_abnormal_neuron_physiology0.72484154
163MP0001663_abnormal_digestive_system0.72449440
164MP0000604_amyloidosis0.71708924
165MP0006035_abnormal_mitochondrial_morpho0.69889021
166MP0003075_altered_response_to0.66513420
167MP0004185_abnormal_adipocyte_glucose0.64581265
168MP0000343_altered_response_to0.63352215
169MP0004510_myositis0.58725403
170MP0002693_abnormal_pancreas_physiology0.56736755
171MP0005390_skeleton_phenotype0.56141597
172MP0000955_abnormal_spinal_cord0.54908638
173MP0009765_abnormal_xenobiotic_induced0.48974671
174MP0002909_abnormal_adrenal_gland0.47784746
175MP0003011_delayed_dark_adaptation0.46935327

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.45522286
2Myositis (HP:0100614)6.17056794
3Recurrent abscess formation (HP:0002722)6.05050271
4Recurrent bacterial skin infections (HP:0005406)5.83785317
5Orchitis (HP:0100796)5.82754597
6Chromosomal breakage induced by crosslinking agents (HP:0003221)5.77624488
7Retrobulbar optic neuritis (HP:0100654)5.37531708
8Optic neuritis (HP:0100653)5.37531708
9Abnormality of macrophages (HP:0004311)5.08797332
10Chromsome breakage (HP:0040012)5.02738603
11Recurrent gram-negative bacterial infections (HP:0005420)4.82580841
12Hypochromic microcytic anemia (HP:0004840)4.75977698
13Stomatitis (HP:0010280)4.72397488
14Duplicated collecting system (HP:0000081)4.55309372
15Gastrointestinal infarctions (HP:0005244)4.46903654
16Elevated erythrocyte sedimentation rate (HP:0003565)4.39485907
17Mediastinal lymphadenopathy (HP:0100721)4.38122605
18Abnormality of the renal collecting system (HP:0004742)4.08228093
19Encephalitis (HP:0002383)4.03570198
20Meningitis (HP:0001287)3.86994714
21Hypochromic anemia (HP:0001931)3.82715359
22Recurrent fungal infections (HP:0002841)3.82695380
23Keratoconjunctivitis sicca (HP:0001097)3.80708958
24Recurrent skin infections (HP:0001581)3.77305136
25Episodic fever (HP:0001954)3.62673415
26Urticaria (HP:0001025)3.59163757
27Abnormal delayed hypersensitivity skin test (HP:0002963)3.57838390
28Keratoconjunctivitis (HP:0001096)3.54513852
29Increased IgE level (HP:0003212)3.42904004
30Spontaneous hematomas (HP:0007420)3.36671745
31Recurrent cutaneous fungal infections (HP:0011370)3.36637358
32Chronic mucocutaneous candidiasis (HP:0002728)3.36637358
33Chest pain (HP:0100749)3.31302097
34Prolonged bleeding time (HP:0003010)3.15368629
35Gingivitis (HP:0000230)3.11786682
36Upper limb muscle weakness (HP:0003484)3.09902391
37Cellulitis (HP:0100658)3.09172539
38Vasculitis (HP:0002633)3.03206788
39Congenital stationary night blindness (HP:0007642)2.88343864
40Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.87769275
41Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.87619828
42Gingival bleeding (HP:0000225)2.87603958
43Septo-optic dysplasia (HP:0100842)2.86372587
44Abnormality of the preputium (HP:0100587)2.84408162
45Prostate neoplasm (HP:0100787)2.82680997
46Abnormality of DNA repair (HP:0003254)2.81952182
47Meckel diverticulum (HP:0002245)2.80573083
48Absent/shortened dynein arms (HP:0200106)2.79072838
49Dynein arm defect of respiratory motile cilia (HP:0012255)2.79072838
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.77956364
51Abnormal ciliary motility (HP:0012262)2.73257576
52Abnormality of the pulmonary veins (HP:0011718)2.68797626
53True hermaphroditism (HP:0010459)2.68650785
54Duplication of thumb phalanx (HP:0009942)2.66175616
55Abnormality of the ileum (HP:0001549)2.65508314
56Hemoptysis (HP:0002105)2.61037650
57Increased IgM level (HP:0003496)2.57079470
58Microcytic anemia (HP:0001935)2.56878415
59Peritonitis (HP:0002586)2.56718346
60Abnormal respiratory epithelium morphology (HP:0012253)2.56153264
61Abnormal respiratory motile cilium morphology (HP:0005938)2.56153264
62Anorexia (HP:0002039)2.54815525
63Sepsis (HP:0100806)2.54214564
64Arterial thrombosis (HP:0004420)2.51154311
65Gastrointestinal inflammation (HP:0004386)2.48174684
66Sex reversal (HP:0012245)2.46854236
67Abnormal sex determination (HP:0012244)2.46854236
68White forelock (HP:0002211)2.46628077
69Atelectasis (HP:0100750)2.41621817
70Abnormality of the septum pellucidum (HP:0007375)2.40181659
71Patchy hypopigmentation of hair (HP:0011365)2.39290943
72Leukocytosis (HP:0001974)2.39150088
73Petechiae (HP:0000967)2.39102309
74Pulmonary embolism (HP:0002204)2.39063124
75Pulmonary infiltrates (HP:0002113)2.37957190
76Inflammation of the large intestine (HP:0002037)2.37811912
77Abnormal hair whorl (HP:0010721)2.34173174
78Epistaxis (HP:0000421)2.32419264
79Aplasia cutis congenita (HP:0001057)2.31829159
80Metaphyseal cupping (HP:0003021)2.31740057
81Congenital sensorineural hearing impairment (HP:0008527)2.31715696
82Panhypogammaglobulinemia (HP:0003139)2.30949215
83Stomach cancer (HP:0012126)2.30895779
84Clubbing of toes (HP:0100760)2.29270064
85Abnormality of the heme biosynthetic pathway (HP:0010472)2.28615964
86Abnormality of chromosome stability (HP:0003220)2.26881499
87Ectopic kidney (HP:0000086)2.23592614
88Lymphopenia (HP:0001888)2.23242961
89Abnormal respiratory motile cilium physiology (HP:0012261)2.22596480
90Absent radius (HP:0003974)2.19233915
91Febrile seizures (HP:0002373)2.18739098
92Acute hepatic failure (HP:0006554)2.18369973
93Conical tooth (HP:0000698)2.17004262
94Triphalangeal thumb (HP:0001199)2.16777765
95Reticulocytopenia (HP:0001896)2.16355291
96Abnormality of the pleura (HP:0002103)2.15325508
97Absent septum pellucidum (HP:0001331)2.13014072
98Decreased central vision (HP:0007663)2.11281808
99Absent forearm bone (HP:0003953)2.08007758
100Aplasia involving forearm bones (HP:0009822)2.08007758
101Attenuation of retinal blood vessels (HP:0007843)2.07973794
102Medial flaring of the eyebrow (HP:0010747)2.07237132
103Nephroblastoma (Wilms tumor) (HP:0002667)2.06915637
104Preaxial hand polydactyly (HP:0001177)2.06612594
105Abnormality of incisor morphology (HP:0011063)2.06460641
106Abnormality of the endocardium (HP:0004306)2.06073575
107Optic nerve hypoplasia (HP:0000609)2.05624985
108Submucous cleft hard palate (HP:0000176)2.05338080
109Abnormality of the axillary hair (HP:0100134)2.04571565
110Abnormality of secondary sexual hair (HP:0009888)2.04571565
111Pancreatic fibrosis (HP:0100732)2.04472001
112Aplasia of the musculature (HP:0100854)2.03787477
113Male pseudohermaphroditism (HP:0000037)2.03458140
114Abnormality of the peritoneum (HP:0002585)2.03139362
115Slow saccadic eye movements (HP:0000514)2.03081638
116Nasolacrimal duct obstruction (HP:0000579)2.02981552
117Deep palmar crease (HP:0006191)2.02958954
118Parakeratosis (HP:0001036)2.01927448
119Osteomalacia (HP:0002749)2.00205474
120Osteomyelitis (HP:0002754)1.98126006
121Abnormality of cells of the lymphoid lineage (HP:0012140)1.97359871
122Abnormal platelet volume (HP:0011876)1.96374475
123Gangrene (HP:0100758)1.96282301
124Pancreatic cysts (HP:0001737)1.95804180
125Overfolded helix (HP:0000396)1.94773088
126Aplasia/Hypoplasia of the lens (HP:0008063)1.93589052
127Keratitis (HP:0000491)1.93406596
128Tubulointerstitial nephritis (HP:0001970)1.92409042
129Hypermelanotic macule (HP:0001034)1.92255265
130Median cleft lip (HP:0000161)1.91620860
131Focal motor seizures (HP:0011153)1.91351258
132Vertigo (HP:0002321)1.90989866
133Embryonal renal neoplasm (HP:0011794)1.90923390
134Nephronophthisis (HP:0000090)1.90142653
135Granulocytopenia (HP:0001913)1.89541917
136Aplasia/Hypoplasia of the earlobes (HP:0009906)1.89046008
137Recurrent viral infections (HP:0004429)1.88138813
138Aganglionic megacolon (HP:0002251)1.87618242
139Increased corneal curvature (HP:0100692)1.87109061
140Keratoconus (HP:0000563)1.87109061
141Prolonged neonatal jaundice (HP:0006579)1.86318988
142Recurrent sinusitis (HP:0011108)1.86203230
143Fetal akinesia sequence (HP:0001989)1.85836727
144Hypergammaglobulinemia (HP:0010702)1.85605044
145Supranuclear gaze palsy (HP:0000605)1.85447299
146Renal agenesis (HP:0000104)1.85437868
147Acne (HP:0001061)1.84219704
148Glomerulopathy (HP:0100820)1.83644066
149Anomalous pulmonary venous return (HP:0010772)1.81787859
150Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.81558363
151Concave nail (HP:0001598)1.79817273
152Amyotrophic lateral sclerosis (HP:0007354)1.79257494
153Amyloidosis (HP:0011034)1.78709616
154Aplasia/hypoplasia of the uterus (HP:0008684)1.77347516
155Viral hepatitis (HP:0006562)1.77022361
156Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76910308
157Abnormality of the lacrimal duct (HP:0011481)1.76597909
158Neoplasm of the adrenal cortex (HP:0100641)1.76541794
159Oligodactyly (hands) (HP:0001180)1.75366835
160Nephrogenic diabetes insipidus (HP:0009806)1.75207484
161Gait imbalance (HP:0002141)1.75007815
162Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74766838
163Long foot (HP:0001833)1.73898725
164Obstructive lung disease (HP:0006536)1.73784716
165Chronic obstructive pulmonary disease (HP:0006510)1.73784716
166Loss of speech (HP:0002371)1.73350722
167Abnormality of the renal medulla (HP:0100957)1.72809196
168Bone marrow hypocellularity (HP:0005528)1.72690478
169Abnormality of T cells (HP:0002843)1.71870000
170Purpura (HP:0000979)1.71437195
171Small intestinal stenosis (HP:0012848)1.71154647
172Duodenal stenosis (HP:0100867)1.71154647
173Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70737947
174Toxemia of pregnancy (HP:0100603)1.70374662
175Difficulty running (HP:0009046)1.70371876
176Hypothermia (HP:0002045)1.70284026
177Choroideremia (HP:0001139)1.69989535
178Pustule (HP:0200039)1.68345475
179Congenital primary aphakia (HP:0007707)1.68098176
180Abnormality of the carotid arteries (HP:0005344)1.66932393
181Short thumb (HP:0009778)1.66580007
182Molar tooth sign on MRI (HP:0002419)1.66278452
183Abnormality of midbrain morphology (HP:0002418)1.66278452
184Ureteral duplication (HP:0000073)1.65980495
185Abnormality of the intervertebral disk (HP:0005108)1.65918036
186Oligohydramnios (HP:0001562)1.65758075
187Esotropia (HP:0000565)1.65690592
188T lymphocytopenia (HP:0005403)1.64291930
189Agitation (HP:0000713)1.64028152
190Neoplasm of the tracheobronchial system (HP:0100552)1.62832421
191Alveolar cell carcinoma (HP:0006519)1.61942248
192Abnormality of the pericardium (HP:0001697)1.61742241
193IgM deficiency (HP:0002850)1.61416561
194Hepatosplenomegaly (HP:0001433)1.60533324
195Papilledema (HP:0001085)1.57149998
196Colitis (HP:0002583)1.57091026
197Postural instability (HP:0002172)1.55997422

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.68021715
2RIPK44.44722245
3CASK3.89227726
4IRAK33.85076903
5MAP4K13.20506832
6IRAK43.17928341
7ZAK3.01396051
8IRAK22.76043713
9ERN12.67613357
10CSK2.65863313
11MARK12.60218533
12MKNK22.58605415
13EPHB12.55223381
14TNIK2.54806580
15MAP2K32.43342112
16TAOK12.40924052
17BLK2.29980329
18IRAK12.24871752
19GRK62.08544084
20CDK192.07853937
21KSR22.02997411
22SIK31.99326421
23SRPK11.98293687
24PNCK1.97436108
25MAP3K111.96708692
26GRK11.90340739
27TYK21.89716182
28BMPR1B1.89260799
29MKNK11.83433431
30PLK41.81218126
31TESK21.80724599
32TLK11.74829470
33TXK1.70107850
34HCK1.64097429
35EIF2AK21.53658688
36MAP2K71.53050712
37NEK61.52901986
38ZAP701.52289039
39MAP3K31.50730923
40BUB11.49959524
41DYRK1B1.49186876
42INSRR1.48705490
43BTK1.45977099
44MAPK131.42971059
45KSR11.41638047
46SYK1.41112833
47MAP2K41.38064431
48MAP3K141.33946817
49JAK21.30402917
50PKN11.28238124
51ADRBK21.25871393
52PRKD21.20428366
53CDK31.10002199
54LRRK21.09275723
55TRIB31.06803596
56PTK61.02943587
57YES11.02192162
58BMPR21.01824737
59BCR1.00669981
60DYRK20.97208113
61AKT30.97004191
62PRPF4B0.94544964
63TBK10.94119112
64EPHA30.93529740
65MAP3K10.93222569
66BRD40.91407674
67NTRK20.90014747
68VRK10.89371310
69CSF1R0.88618947
70LCK0.87025259
71CLK10.86036155
72PDK10.85061984
73RAF10.84680141
74JAK30.84006374
75TNK20.82724672
76EPHB20.81020956
77MAP3K70.80558273
78MUSK0.79447145
79STK110.77822865
80GRK70.77601692
81NME10.77031546
82STK380.76210804
83MAP3K60.75223908
84TAOK20.75197729
85CAMK2B0.74867989
86PDPK10.74263554
87SGK30.73978252
88MARK30.73243025
89OXSR10.72108823
90TTK0.71772067
91PRKCZ0.71601211
92FYN0.70701128
93PRKCE0.69274234
94PRKCI0.66658947
95RPS6KL10.65680598
96RPS6KC10.65680598
97MATK0.65059253
98DAPK20.64476375
99TAOK30.63766854
100CDK80.62419359
101PAK60.60320340
102NLK0.59708387
103RPS6KA60.58041974
104EPHA20.57199745
105DYRK1A0.56965473
106IKBKE0.55901068
107MAPK150.55521574
108SIK20.55497754
109PLK30.54331254
110RPS6KA20.54120997
111UHMK10.53548169
112TEC0.51919755
113MAP3K120.51671788
114KIT0.51620814
115MAP3K50.50734390
116PAK30.50252609
117MAP2K20.49814837
118SIK10.48740541
119RET0.48428154
120WNK30.48087083
121MAP3K130.47674434
122MAP3K20.47235051
123RPS6KA50.45905844
124FES0.45497902
125RPS6KA40.45482505
126ERBB30.45063922
127PBK0.44785243
128PRKCQ0.44728982
129NUAK10.43901712
130CAMK2D0.43886472
131ITK0.43706543
132CAMK40.43326368
133CSNK1A1L0.41816833
134PTK2B0.41730460
135ATR0.41314752
136RPS6KA10.41309130
137PLK10.41207955
138BRAF0.40399163
139PLK20.39976279
140DYRK30.39358023
141CAMKK10.38602313
142LYN0.38562927
143SMG10.37961028
144CAMK2A0.37442655
145MAPKAPK50.37052972
146IKBKB0.36659927
147CAMK2G0.36300699
148EIF2AK10.35928770
149STK100.35752708
150STK390.35460272
151PKN20.35088924
152MAPK70.34889563
153NTRK30.34841326
154EPHA40.33687721
155AURKA0.33277127
156HIPK20.32460262
157MARK20.30870756
158MAP3K40.30467016
159SGK20.30280581
160TIE10.30245529
161STK38L0.29612845
162CDK70.28434036
163SGK4940.27535275
164SGK2230.27535275
165CHEK20.27125785
166PRKG10.26936776
167PRKCG0.25954791
168CSNK1G30.25367176
169FGR0.25090510
170PRKACA0.24065497
171CDC42BPA0.20659558
172CDK10.19992699

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.31935283
2Osteoclast differentiation_Homo sapiens_hsa043802.80536101
3Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.59302726
4Phototransduction_Homo sapiens_hsa047442.56224735
5RNA polymerase_Homo sapiens_hsa030202.45524423
6Leishmaniasis_Homo sapiens_hsa051402.44840366
7B cell receptor signaling pathway_Homo sapiens_hsa046622.36975185
8Nicotine addiction_Homo sapiens_hsa050332.29744465
9Homologous recombination_Homo sapiens_hsa034402.29143495
10Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.17348849
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17214085
12Acute myeloid leukemia_Homo sapiens_hsa052212.15048898
13Tuberculosis_Homo sapiens_hsa051522.08511696
14Staphylococcus aureus infection_Homo sapiens_hsa051502.06490302
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.91850473
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.87918665
17Sphingolipid metabolism_Homo sapiens_hsa006001.84041952
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.83575051
19Non-small cell lung cancer_Homo sapiens_hsa052231.76848975
20Basal transcription factors_Homo sapiens_hsa030221.66041057
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.65459292
22Phagosome_Homo sapiens_hsa041451.64558277
23Autoimmune thyroid disease_Homo sapiens_hsa053201.62721763
24Proteasome_Homo sapiens_hsa030501.60944499
25Mismatch repair_Homo sapiens_hsa034301.50627491
26Pyrimidine metabolism_Homo sapiens_hsa002401.49415278
27Taste transduction_Homo sapiens_hsa047421.49262537
28Arachidonic acid metabolism_Homo sapiens_hsa005901.49262173
29Non-homologous end-joining_Homo sapiens_hsa034501.47198476
30Primary immunodeficiency_Homo sapiens_hsa053401.41780040
31Nucleotide excision repair_Homo sapiens_hsa034201.41579491
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.37846130
33Endometrial cancer_Homo sapiens_hsa052131.36047573
34Ether lipid metabolism_Homo sapiens_hsa005651.35960387
35DNA replication_Homo sapiens_hsa030301.33045389
36Viral myocarditis_Homo sapiens_hsa054161.31719482
37VEGF signaling pathway_Homo sapiens_hsa043701.29715591
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26914432
39Base excision repair_Homo sapiens_hsa034101.25942405
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25733280
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24572242
42Salmonella infection_Homo sapiens_hsa051321.23318494
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23036370
44Allograft rejection_Homo sapiens_hsa053301.22092530
45Serotonergic synapse_Homo sapiens_hsa047261.20945848
46Pancreatic cancer_Homo sapiens_hsa052121.20415938
47Shigellosis_Homo sapiens_hsa051311.19822328
48Hepatitis B_Homo sapiens_hsa051611.18053016
49Legionellosis_Homo sapiens_hsa051341.18007328
50Chronic myeloid leukemia_Homo sapiens_hsa052201.17535400
51Spliceosome_Homo sapiens_hsa030401.17455101
52Graft-versus-host disease_Homo sapiens_hsa053321.17313304
53Type II diabetes mellitus_Homo sapiens_hsa049301.16716681
54Purine metabolism_Homo sapiens_hsa002301.14612298
55Influenza A_Homo sapiens_hsa051641.14187264
56Colorectal cancer_Homo sapiens_hsa052101.13767351
57Renal cell carcinoma_Homo sapiens_hsa052111.12894136
58Endocytosis_Homo sapiens_hsa041441.12739519
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11964415
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11954678
61Morphine addiction_Homo sapiens_hsa050321.11320531
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08866549
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08558738
64Antigen processing and presentation_Homo sapiens_hsa046121.07467439
65Toxoplasmosis_Homo sapiens_hsa051451.06467275
66Leukocyte transendothelial migration_Homo sapiens_hsa046701.05000381
67Apoptosis_Homo sapiens_hsa042101.04933754
68Intestinal immune network for IgA production_Homo sapiens_hsa046721.04749455
69Type I diabetes mellitus_Homo sapiens_hsa049401.04626205
70Asthma_Homo sapiens_hsa053101.04105423
71Neurotrophin signaling pathway_Homo sapiens_hsa047221.03941559
72Oxidative phosphorylation_Homo sapiens_hsa001901.03451464
73Prolactin signaling pathway_Homo sapiens_hsa049171.02992233
74Hepatitis C_Homo sapiens_hsa051601.00433200
75Axon guidance_Homo sapiens_hsa043600.99420107
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99118604
77Linoleic acid metabolism_Homo sapiens_hsa005910.98878946
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98341717
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97938926
80Choline metabolism in cancer_Homo sapiens_hsa052310.97734610
81FoxO signaling pathway_Homo sapiens_hsa040680.97243260
82Protein export_Homo sapiens_hsa030600.94335486
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.93652538
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93383312
85Hematopoietic cell lineage_Homo sapiens_hsa046400.93261437
86Other glycan degradation_Homo sapiens_hsa005110.92807344
87Ribosome_Homo sapiens_hsa030100.91177147
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.89442212
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.88687498
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87920478
91Platelet activation_Homo sapiens_hsa046110.86892909
92Basal cell carcinoma_Homo sapiens_hsa052170.86298275
93ErbB signaling pathway_Homo sapiens_hsa040120.85687074
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84246548
95RNA degradation_Homo sapiens_hsa030180.81604017
96Huntingtons disease_Homo sapiens_hsa050160.80065635
97Rheumatoid arthritis_Homo sapiens_hsa053230.79482953
98TNF signaling pathway_Homo sapiens_hsa046680.79120254
99mTOR signaling pathway_Homo sapiens_hsa041500.79018843
100p53 signaling pathway_Homo sapiens_hsa041150.78189975
101Measles_Homo sapiens_hsa051620.76605168
102Viral carcinogenesis_Homo sapiens_hsa052030.76359248
103Regulation of autophagy_Homo sapiens_hsa041400.75727742
104Glutamatergic synapse_Homo sapiens_hsa047240.75056616
105Cholinergic synapse_Homo sapiens_hsa047250.74188159
106MAPK signaling pathway_Homo sapiens_hsa040100.72438436
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72055700
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70105603
109Inositol phosphate metabolism_Homo sapiens_hsa005620.70077358
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.69962755
111Vitamin B6 metabolism_Homo sapiens_hsa007500.69229091
112Synaptic vesicle cycle_Homo sapiens_hsa047210.68564337
113Cell cycle_Homo sapiens_hsa041100.67374474
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.66787173
115Rap1 signaling pathway_Homo sapiens_hsa040150.65747940
116Wnt signaling pathway_Homo sapiens_hsa043100.64653963
117GnRH signaling pathway_Homo sapiens_hsa049120.64404203
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61126130
119mRNA surveillance pathway_Homo sapiens_hsa030150.60794586
120Vitamin digestion and absorption_Homo sapiens_hsa049770.60474614
121Hedgehog signaling pathway_Homo sapiens_hsa043400.60230024
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60221363
123Fatty acid elongation_Homo sapiens_hsa000620.58856554
124Insulin signaling pathway_Homo sapiens_hsa049100.57535645
125Alzheimers disease_Homo sapiens_hsa050100.57221174
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56689152
127Epstein-Barr virus infection_Homo sapiens_hsa051690.56482245
128GABAergic synapse_Homo sapiens_hsa047270.56072544
129Parkinsons disease_Homo sapiens_hsa050120.55476543
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54017086
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53449904
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52511626
133Calcium signaling pathway_Homo sapiens_hsa040200.50509682
134Malaria_Homo sapiens_hsa051440.50224679
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49812881
136Collecting duct acid secretion_Homo sapiens_hsa049660.48984537
137Insulin resistance_Homo sapiens_hsa049310.47670394
138Estrogen signaling pathway_Homo sapiens_hsa049150.47317200
139Notch signaling pathway_Homo sapiens_hsa043300.46567874
140Glioma_Homo sapiens_hsa052140.46069652
141Pertussis_Homo sapiens_hsa051330.45871850
142Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45805654
143Ras signaling pathway_Homo sapiens_hsa040140.45318942
144African trypanosomiasis_Homo sapiens_hsa051430.45243790
145Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45002004
146Olfactory transduction_Homo sapiens_hsa047400.43231190
147Circadian rhythm_Homo sapiens_hsa047100.43091899
148Herpes simplex infection_Homo sapiens_hsa051680.40911563
149RNA transport_Homo sapiens_hsa030130.40704384
150Steroid biosynthesis_Homo sapiens_hsa001000.40603763
151Glycosaminoglycan degradation_Homo sapiens_hsa005310.39921549
152T cell receptor signaling pathway_Homo sapiens_hsa046600.39707733
153Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38738684
154Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37710288
155Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36799478
156Chemokine signaling pathway_Homo sapiens_hsa040620.34297908
157Long-term depression_Homo sapiens_hsa047300.33594552
158Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33470879
159Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33349899
160Cocaine addiction_Homo sapiens_hsa050300.33196025
161Jak-STAT signaling pathway_Homo sapiens_hsa046300.32258241
162Glycerophospholipid metabolism_Homo sapiens_hsa005640.30668082
163Toll-like receptor signaling pathway_Homo sapiens_hsa046200.29608487
164Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29471427
165Retinol metabolism_Homo sapiens_hsa008300.29460183

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