TIGD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GDP-mannose metabolic process (GO:0019673)9.66063153
2negative regulation of cell aging (GO:0090344)8.86398046
3proline metabolic process (GO:0006560)8.80414979
4transcription from mitochondrial promoter (GO:0006390)8.07659382
5regulation of skeletal muscle contraction (GO:0014819)7.96279790
6meiotic chromosome segregation (GO:0045132)7.36109711
7embryonic process involved in female pregnancy (GO:0060136)7.27114531
8adenosine receptor signaling pathway (GO:0001973)7.19679608
9positive regulation of protein homooligomerization (GO:0032464)6.84253179
10replication fork processing (GO:0031297)6.69622931
11regulation of synapse structural plasticity (GO:0051823)6.69117383
12oxidative demethylation (GO:0070989)6.52043363
13establishment of apical/basal cell polarity (GO:0035089)6.37873521
14G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)6.24661936
15peptidyl-glutamic acid carboxylation (GO:0017187)6.17476282
16protein carboxylation (GO:0018214)6.17476282
17lens fiber cell differentiation (GO:0070306)6.16263998
18regulation of integrin activation (GO:0033623)6.12401377
19rRNA methylation (GO:0031167)6.10191923
20regulation of protein homooligomerization (GO:0032462)5.97820905
21DNA deamination (GO:0045006)5.93666773
22purinergic nucleotide receptor signaling pathway (GO:0035590)5.90048777
23mitotic cell cycle arrest (GO:0071850)5.74021166
24adenine nucleotide transport (GO:0051503)5.62695659
25establishment of monopolar cell polarity (GO:0061162)5.62486108
26establishment or maintenance of monopolar cell polarity (GO:0061339)5.62486108
27positive regulation of protein kinase C signaling (GO:0090037)5.60925250
28negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.57647311
29rRNA modification (GO:0000154)5.49085519
30regulation of cytokine production involved in inflammatory response (GO:1900015)5.46496545
31maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.37934726
32somatic hypermutation of immunoglobulin genes (GO:0016446)5.30066573
33somatic diversification of immune receptors via somatic mutation (GO:0002566)5.30066573
34purine ribonucleotide transport (GO:0015868)5.28773575
35negative regulation of cell cycle arrest (GO:0071157)5.22183872
36mitochondrial DNA metabolic process (GO:0032042)5.16122023
37DNA replication checkpoint (GO:0000076)4.99721334
38glutamine family amino acid biosynthetic process (GO:0009084)4.97547203
39UV protection (GO:0009650)4.97364618
40negative regulation of JAK-STAT cascade (GO:0046426)4.92044425
41DNA strand renaturation (GO:0000733)4.89351687
42response to ATP (GO:0033198)4.80572600
43embryonic placenta development (GO:0001892)4.77342696
44mitotic G1 DNA damage checkpoint (GO:0031571)4.68350286
45sensory perception of taste (GO:0050909)4.65820243
46negative regulation of Ras GTPase activity (GO:0034261)4.55258666
47poly(A)+ mRNA export from nucleus (GO:0016973)4.53412316
48regulation of nuclear cell cycle DNA replication (GO:0033262)4.53244589
49regulation of cell aging (GO:0090342)4.51842016
50cellular response to zinc ion (GO:0071294)4.51117212
51cellular response to ATP (GO:0071318)4.49464086
52behavioral response to nicotine (GO:0035095)4.45798375
53nucleoside transmembrane transport (GO:1901642)4.44310470
54estrogen biosynthetic process (GO:0006703)4.42164108
55negative regulation of fatty acid biosynthetic process (GO:0045717)4.41029581
56detection of light stimulus involved in visual perception (GO:0050908)4.39163870
57detection of light stimulus involved in sensory perception (GO:0050962)4.39163870
58transepithelial transport (GO:0070633)4.36954555
59purinergic receptor signaling pathway (GO:0035587)4.35518729
60cell migration in hindbrain (GO:0021535)4.35425560
61purine nucleotide transport (GO:0015865)4.30437091
62tRNA modification (GO:0006400)4.25921299
63folic acid metabolic process (GO:0046655)4.25177516
64negative regulation of protein oligomerization (GO:0032460)4.23558674
65nucleotide-sugar biosynthetic process (GO:0009226)4.22909192
66mitotic G1/S transition checkpoint (GO:0044819)4.20039357
67viral mRNA export from host cell nucleus (GO:0046784)4.19161393
68G1 DNA damage checkpoint (GO:0044783)4.18043508
69mRNA cleavage (GO:0006379)4.12803996
70convergent extension (GO:0060026)4.10294396
71glial cell migration (GO:0008347)4.08064303
72regulation of translational fidelity (GO:0006450)4.07330720
73spliceosomal tri-snRNP complex assembly (GO:0000244)4.05951768
74sex determination (GO:0007530)4.05777602
75positive regulation of heat generation (GO:0031652)4.04111633
76nucleotide transmembrane transport (GO:1901679)4.01597445
77alkaloid metabolic process (GO:0009820)4.00997005
78urinary tract smooth muscle contraction (GO:0014848)4.00967510
79apoptotic process involved in morphogenesis (GO:0060561)4.00581944
80melanin biosynthetic process (GO:0042438)4.00213443
81granulocyte differentiation (GO:0030851)3.99422355
82positive regulation of protein oligomerization (GO:0032461)3.99032435
83embryonic camera-type eye development (GO:0031076)3.98172655
84establishment of protein localization to mitochondrial membrane (GO:0090151)3.96815803
85auditory receptor cell stereocilium organization (GO:0060088)3.95078622
86regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.86563684
87regulation of protein oligomerization (GO:0032459)3.86259042
88mannose metabolic process (GO:0006013)3.83515197
89G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.79886928
90positive regulation by host of viral transcription (GO:0043923)3.79269259
91protein insertion into membrane (GO:0051205)3.78812197
92negative regulation of heart rate (GO:0010459)3.78710019
93negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.78586128
94dosage compensation (GO:0007549)3.74714819
95grooming behavior (GO:0007625)3.74481935
96negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.74364806
97base-excision repair (GO:0006284)3.74280787
98anatomical structure regression (GO:0060033)3.72653491
99melanin metabolic process (GO:0006582)3.70011814
100histone phosphorylation (GO:0016572)3.69485887
101phosphatidylglycerol biosynthetic process (GO:0006655)3.68565524
102face development (GO:0060324)3.65456097
103sulfur amino acid catabolic process (GO:0000098)3.65412316
104DNA integration (GO:0015074)3.64337733
105sphingosine metabolic process (GO:0006670)3.63597322
106regulation of phospholipid biosynthetic process (GO:0071071)3.57891533
107semaphorin-plexin signaling pathway (GO:0071526)3.57414746
108positive regulation of developmental pigmentation (GO:0048087)3.57147469
109regulation of cAMP-dependent protein kinase activity (GO:2000479)3.52861277
110regulation of protein kinase A signaling (GO:0010738)3.51921649
111pseudouridine synthesis (GO:0001522)3.50585983
112peristalsis (GO:0030432)3.49740994
113cornea development in camera-type eye (GO:0061303)3.42916893
114diol metabolic process (GO:0034311)3.42477037
115double-strand break repair via nonhomologous end joining (GO:0006303)3.37399947
116non-recombinational repair (GO:0000726)3.37399947
117mitochondrial RNA metabolic process (GO:0000959)3.36875926
118nucleoside transport (GO:0015858)3.36518245
119negative regulation of mRNA processing (GO:0050686)3.36395048
120positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.36346978
121regulation of RNA export from nucleus (GO:0046831)3.36320472
122sphingomyelin metabolic process (GO:0006684)3.32972423
123ribosomal small subunit biogenesis (GO:0042274)3.31124654
124negative regulation of interleukin-8 production (GO:0032717)3.27737188
125regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.23386718
126purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.21587155
127ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.21587155
128nucleoside bisphosphate biosynthetic process (GO:0033866)3.21587155
129very-low-density lipoprotein particle assembly (GO:0034379)3.20258678
130formation of translation preinitiation complex (GO:0001731)3.19383108
131cellular anion homeostasis (GO:0030002)3.18776529
132negative regulation of viral release from host cell (GO:1902187)3.16973230
133synaptic vesicle endocytosis (GO:0048488)3.16396313
134base-excision repair, AP site formation (GO:0006285)3.15203302
135activation of Rac GTPase activity (GO:0032863)3.15178080
136endocytic recycling (GO:0032456)3.13771853
137protein localization to endosome (GO:0036010)3.13475542
138mitotic nuclear envelope reassembly (GO:0007084)3.12436690
139nuclear envelope reassembly (GO:0031468)3.12436690
140DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.12347462
141secondary metabolite biosynthetic process (GO:0044550)3.10988483
142mitochondrion transport along microtubule (GO:0047497)3.10714190
143establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.10714190
144regulation of cell size (GO:0008361)3.10428251
145dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.06832801
146maturation of 5.8S rRNA (GO:0000460)3.05772785
147positive regulation of DNA repair (GO:0045739)3.04576484
148trivalent inorganic anion homeostasis (GO:0072506)3.04334520
149phosphate ion homeostasis (GO:0055062)3.04334520
150histone H4-K12 acetylation (GO:0043983)3.04295086
151positive regulation of circadian rhythm (GO:0042753)3.03330634
152folic acid transport (GO:0015884)3.03309086
153pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.03073002
154N-glycan processing (GO:0006491)3.02786385
155regulation of sister chromatid cohesion (GO:0007063)3.01805816
156membrane tubulation (GO:0097320)2.99368244
157mitochondrion distribution (GO:0048311)2.99007589
158protein import into peroxisome matrix (GO:0016558)2.98375139
159protein targeting to vacuole (GO:0006623)2.97831750
160protein targeting to lysosome (GO:0006622)2.97831750
161establishment of protein localization to vacuole (GO:0072666)2.97831750
162atrioventricular valve morphogenesis (GO:0003181)2.96976786
163regulation of respiratory system process (GO:0044065)2.96835339
164DNA topological change (GO:0006265)2.96760957
165regulation of mitochondrial depolarization (GO:0051900)2.95062755
166modulation by virus of host process (GO:0019054)2.94972000
167positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.94519259
168embryonic eye morphogenesis (GO:0048048)2.94035554
169labyrinthine layer development (GO:0060711)2.93172687
170trophectodermal cell differentiation (GO:0001829)2.92826255
171DNA demethylation (GO:0080111)2.92772293
172apoptotic process involved in development (GO:1902742)2.92089728
173enteric nervous system development (GO:0048484)2.91574604
174regulation of early endosome to late endosome transport (GO:2000641)2.91430597
175intracellular estrogen receptor signaling pathway (GO:0030520)2.91088982
176sialylation (GO:0097503)2.89875635
177nodal signaling pathway (GO:0038092)2.89233760
178RNA modification (GO:0009451)2.88938870
179nucleotide-excision repair, DNA gap filling (GO:0006297)2.88256088
180type B pancreatic cell proliferation (GO:0044342)2.87885922
181misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.86552651
182DNA damage response, signal transduction resulting in transcription (GO:0042772)2.85792707
183regulation of heat generation (GO:0031650)2.84892928
184negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)2.84393468
185positive regulation of odontogenesis (GO:0042482)2.83895424
186neuromuscular synaptic transmission (GO:0007274)2.81773591
187cardiolipin metabolic process (GO:0032048)2.81483093
188phosphate ion transmembrane transport (GO:0035435)2.78549285
189planar cell polarity pathway involved in neural tube closure (GO:0090179)2.77564460
190regulation of chromatin binding (GO:0035561)2.74527614
1913-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.74027902
192purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.74027902
193proline biosynthetic process (GO:0006561)11.4214134

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.72188941
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.38656255
3SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.33687955
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.01920936
5SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.89961825
6ERG_21242973_ChIP-ChIP_JURKAT_Human2.84700530
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.82190916
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.82190916
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.82190916
10VDR_21846776_ChIP-Seq_THP-1_Human2.72565811
11* XRN2_22483619_ChIP-Seq_HELA_Human2.66980288
12* LXR_22292898_ChIP-Seq_THP-1_Human2.66951413
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.45488648
14* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.45395344
15* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.45265744
16SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.42950186
17MAF_26560356_Chip-Seq_TH2_Human2.33630544
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.27180652
19POU5F1_16518401_ChIP-PET_MESCs_Mouse2.26635608
20KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.19104365
21ZNF263_19887448_ChIP-Seq_K562_Human2.17053453
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.09258050
23MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.06394081
24NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.03681362
25* BCL6_27268052_Chip-Seq_Bcells_Human2.02389332
26ZFP281_18757296_ChIP-ChIP_E14_Mouse1.98271688
27VDR_24763502_ChIP-Seq_THP-1_Human1.94604095
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.92277234
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92160406
30SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.90769041
31TCF3_18692474_ChIP-Seq_MESCs_Mouse1.89548742
32TET1_21451524_ChIP-Seq_MESCs_Mouse1.89431587
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.89237606
34ZFP281_27345836_Chip-Seq_ESCs_Mouse1.88369301
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.88018381
36MAF_26560356_Chip-Seq_TH1_Human1.85117867
37NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.83195425
38CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.82562101
39KDM2B_26808549_Chip-Seq_DND41_Human1.77449460
40SMC4_20622854_ChIP-Seq_HELA_Human1.76509669
41MYC_22102868_ChIP-Seq_BL_Human1.76151087
42CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.75752196
43RACK7_27058665_Chip-Seq_MCF-7_Human1.73340955
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71956489
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70299344
46PU.1_20513432_ChIP-Seq_Bcells_Mouse1.69680518
47SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.68597547
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.68103583
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.67019548
50CTCF_21964334_Chip-Seq_Bcells_Human1.66667440
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.63759585
52NANOG_21062744_ChIP-ChIP_HESCs_Human1.62994448
53FOXM1_23109430_ChIP-Seq_U2OS_Human1.61411161
54DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.60840656
55TCF3_18692474_ChIP-Seq_MEFs_Mouse1.58673791
56ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.57848600
57SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.57739304
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.57296922
59* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.57171435
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56951624
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.56767102
62TP53_22127205_ChIP-Seq_IMR90_Human1.54702307
63KDM2B_26808549_Chip-Seq_K562_Human1.53409341
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50630518
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50538953
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49761722
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47111179
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46703789
69HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44789639
70CTCF_20526341_ChIP-Seq_ESCs_Human1.44168794
71* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.44073782
72* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.42709090
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40753942
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.40685498
75EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40209342
76* UTX_26944678_Chip-Seq_JUKART_Human1.40168276
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39191948
78RXRA_24833708_ChIP-Seq_LIVER_Mouse1.36757412
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36139362
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35992634
81TCF7_22412390_ChIP-Seq_EML_Mouse1.35901064
82POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.35616076
83SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.34271929
84CTCF_21964334_ChIP-Seq_BJAB-B_Human1.33884271
85RARB_24833708_ChIP-Seq_LIVER_Mouse1.33388417
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.32722999
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32173497
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32022656
89SA1_27219007_Chip-Seq_Bcells_Human1.31599768
90ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30879618
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29985054
92DCP1A_22483619_ChIP-Seq_HELA_Human1.28907908
93* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28505461
94RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.28374948
95ETS1_21867929_ChIP-Seq_TH2_Mouse1.27798292
96TP53_20018659_ChIP-ChIP_R1E_Mouse1.27673234
97* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27170207
98RING1B_27294783_Chip-Seq_NPCs_Mouse1.26711491
99ATF3_27146783_Chip-Seq_COLON_Human1.26428314
100RXR_22158963_ChIP-Seq_LIVER_Mouse1.25535853
101GABP_19822575_ChIP-Seq_HepG2_Human1.25079413
102SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24890385
103FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24716610
104ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24096468
105CTCF_26484167_Chip-Seq_Bcells_Mouse1.23399042
106EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23181528
107ERA_21632823_ChIP-Seq_H3396_Human1.22329722
108SOX2_18692474_ChIP-Seq_MESCs_Mouse1.21557280
109DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20714121
110KDM2B_26808549_Chip-Seq_JURKAT_Human1.20460224
111FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20024026
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19008684
113SA1_27219007_Chip-Seq_ERYTHROID_Human1.18437511
114TRIM28_21343339_ChIP-Seq_HEK293_Human1.18330565
115CIITA_25753668_ChIP-Seq_RAJI_Human1.17184384
116SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15935915
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15175055
118RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15016811
119NANOG_18692474_ChIP-Seq_MESCs_Mouse1.14230190
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12902916
121JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.12525578
122SOX2_18692474_ChIP-Seq_MEFs_Mouse1.11459525
123MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11100537
124STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10818794
125PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10086574
126RARA_24833708_ChIP-Seq_LIVER_Mouse1.10056558
127UBF1/2_26484160_Chip-Seq_HMECs_Human1.10055724
128NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09711483
129PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.09480717
130CREB1_26743006_Chip-Seq_LNCaP_Human1.09276758
131CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08589196
132TET1_21490601_ChIP-Seq_MESCs_Mouse1.07518295
133CTCF_27219007_Chip-Seq_Bcells_Human1.07475722
134CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07457401
135UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06752285
136P68_20966046_ChIP-Seq_HELA_Human1.06613347
137SPI1_26923725_Chip-Seq_HPCs_Mouse1.06487755
138ETS1_20019798_ChIP-Seq_JURKAT_Human1.06259249
139SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05760413
140NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.05665487
141OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05656553
142BCOR_27268052_Chip-Seq_Bcells_Human1.05619764
143ESR2_21235772_ChIP-Seq_MCF-7_Human1.05305568
144* NCOR1_26117541_ChIP-Seq_K562_Human1.05181041
145FOXP1_21924763_ChIP-Seq_HESCs_Human1.05167217
146TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.05065820
147THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05028826
148TP63_22573176_ChIP-Seq_HFKS_Human1.03672997
149PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03598029
150PHF8_20622854_ChIP-Seq_HELA_Human1.03430480
151* E2F1_20622854_ChIP-Seq_HELA_Human1.02368262
152PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01134702
153SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00087089
154YY1_22570637_ChIP-Seq_MALME-3M_Human0.99476658
155MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99280936
156RUNX1_27514584_Chip-Seq_MCF-7_Human0.98973623
157NOTCH1_21737748_ChIP-Seq_TLL_Human0.98792889

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity5.99172573
2MP0008057_abnormal_DNA_replication5.60101848
3MP0003136_yellow_coat_color5.46206301
4MP0005423_abnormal_somatic_nervous5.40433312
5MP0005171_absent_coat_pigmentation4.91936562
6MP0004233_abnormal_muscle_weight4.35295926
7MP0009278_abnormal_bone_marrow4.20379350
8MP0010030_abnormal_orbit_morphology4.12256887
9MP0001188_hyperpigmentation3.74316262
10MP0005409_darkened_coat_color3.49807839
11MP0002009_preneoplasia3.44578957
12MP0005083_abnormal_biliary_tract3.29602385
13MP0001968_abnormal_touch/_nociception2.50082435
14MP0004133_heterotaxia2.45019512
15MP0008995_early_reproductive_senescence2.43286868
16MP0008875_abnormal_xenobiotic_pharmacok2.35643622
17MP0003283_abnormal_digestive_organ2.29529056
18MP0001661_extended_life_span2.29259520
19MP0003890_abnormal_embryonic-extraembry2.22266034
20MP0001502_abnormal_circadian_rhythm2.11586045
21MP0001756_abnormal_urination2.10204649
22MP0004381_abnormal_hair_follicle2.09080249
23MP0003119_abnormal_digestive_system2.03849429
24MP0002249_abnormal_larynx_morphology2.02961993
25MP0006072_abnormal_retinal_apoptosis1.98856019
26MP0000538_abnormal_urinary_bladder1.96111846
27MP0002653_abnormal_ependyma_morphology1.95344652
28MP0000750_abnormal_muscle_regeneration1.94717226
29MP0005397_hematopoietic_system_phenotyp1.94489916
30MP0001545_abnormal_hematopoietic_system1.94489916
31MP0002638_abnormal_pupillary_reflex1.89640227
32MP0002282_abnormal_trachea_morphology1.86240075
33MP0008877_abnormal_DNA_methylation1.85019267
34MP0002736_abnormal_nociception_after1.84818136
35MP0005645_abnormal_hypothalamus_physiol1.74582330
36MP0002160_abnormal_reproductive_system1.74287409
37MP0005365_abnormal_bile_salt1.67358957
38MP0005174_abnormal_tail_pigmentation1.66207720
39MP0005076_abnormal_cell_differentiation1.64040813
40MP0005085_abnormal_gallbladder_physiolo1.62870167
41MP0000579_abnormal_nail_morphology1.60619261
42MP0000013_abnormal_adipose_tissue1.59720956
43MP0005501_abnormal_skin_physiology1.53642817
44MP0001340_abnormal_eyelid_morphology1.46648206
45MP0000462_abnormal_digestive_system1.46523263
46MP0003786_premature_aging1.44993444
47MP0001293_anophthalmia1.44845631
48MP0003567_abnormal_fetal_cardiomyocyte1.43410051
49MP0002084_abnormal_developmental_patter1.43409173
50MP0003693_abnormal_embryo_hatching1.42948038
51MP0003453_abnormal_keratinocyte_physiol1.40546589
52MP0004197_abnormal_fetal_growth/weight/1.40209050
53MP0010352_gastrointestinal_tract_polyps1.39834474
54MP0002269_muscular_atrophy1.39539218
55MP0002086_abnormal_extraembryonic_tissu1.39170164
56MP0010094_abnormal_chromosome_stability1.36879578
57MP0000639_abnormal_adrenal_gland1.34970642
58MP0001697_abnormal_embryo_size1.32470609
59MP0000015_abnormal_ear_pigmentation1.29601976
60MP0002085_abnormal_embryonic_tissue1.28482199
61MP0003172_abnormal_lysosome_physiology1.27741965
62MP0002111_abnormal_tail_morphology1.26690439
63MP0004130_abnormal_muscle_cell1.23671091
64MP0003385_abnormal_body_wall1.22927311
65MP0001346_abnormal_lacrimal_gland1.20661437
66MP0005332_abnormal_amino_acid1.16043454
67MP0001873_stomach_inflammation1.15517235
68MP0000470_abnormal_stomach_morphology1.14820614
69MP0003137_abnormal_impulse_conducting1.14330419
70MP0002254_reproductive_system_inflammat1.13867184
71MP0000762_abnormal_tongue_morphology1.13087587
72MP0003077_abnormal_cell_cycle1.12613341
73MP0009115_abnormal_fat_cell1.11845963
74MP0002932_abnormal_joint_morphology1.11374080
75MP0001919_abnormal_reproductive_system1.10115834
76MP0000747_muscle_weakness1.08732323
77MP0000371_diluted_coat_color1.08483295
78MP0002735_abnormal_chemical_nociception1.07236714
79MP0001664_abnormal_digestion1.06275601
80MP0008932_abnormal_embryonic_tissue1.04313167
81MP0003755_abnormal_palate_morphology1.03745415
82MP0004134_abnormal_chest_morphology1.03414206
83MP0003806_abnormal_nucleotide_metabolis1.01504218
84MP0005410_abnormal_fertilization1.00829604
85MP0003935_abnormal_craniofacial_develop1.00523037
86MP0003705_abnormal_hypodermis_morpholog0.99745559
87MP0002116_abnormal_craniofacial_bone0.99501230
88MP0001958_emphysema0.98434493
89MP0002060_abnormal_skin_morphology0.97381500
90MP0004957_abnormal_blastocyst_morpholog0.95970629
91MP0003942_abnormal_urinary_system0.95649117
92MP0001672_abnormal_embryogenesis/_devel0.93338776
93MP0005380_embryogenesis_phenotype0.93338776
94MP0005623_abnormal_meninges_morphology0.92443965
95MP0002114_abnormal_axial_skeleton0.92376653
96MP0005551_abnormal_eye_electrophysiolog0.91453558
97MP0005584_abnormal_enzyme/coenzyme_acti0.89364178
98MP0005075_abnormal_melanosome_morpholog0.88820380
99MP0003656_abnormal_erythrocyte_physiolo0.88559118
100MP0001765_abnormal_ion_homeostasis0.88396181
101MP0004142_abnormal_muscle_tone0.86470135
102MP0001324_abnormal_eye_pigmentation0.86180247
103MP0002796_impaired_skin_barrier0.85759727
104MP0000490_abnormal_crypts_of0.85663713
105MP0005257_abnormal_intraocular_pressure0.85240990
106MP0000003_abnormal_adipose_tissue0.84566780
107MP0000955_abnormal_spinal_cord0.84445205
108MP0000367_abnormal_coat/_hair0.83932217
109MP0004043_abnormal_pH_regulation0.83866534
110MP0000751_myopathy0.82257929
111MP0004185_abnormal_adipocyte_glucose0.81035711
112MP0009053_abnormal_anal_canal0.79232102
113MP0005248_abnormal_Harderian_gland0.79030720
114MP0002751_abnormal_autonomic_nervous0.78531581
115MP0009931_abnormal_skin_appearance0.78370053
116MP0000358_abnormal_cell_content/0.77278083
117MP0000049_abnormal_middle_ear0.76059926
118MP0010771_integument_phenotype0.75759783
119MP0005330_cardiomyopathy0.75683744
120MP0000778_abnormal_nervous_system0.75630116
121MP0005266_abnormal_metabolism0.75617611
122MP0002971_abnormal_brown_adipose0.74636857
123MP0008058_abnormal_DNA_repair0.73910236
124MP0001730_embryonic_growth_arrest0.73501938
125MP0002970_abnormal_white_adipose0.72942464
126MP0009046_muscle_twitch0.72940257
127MP0002075_abnormal_coat/hair_pigmentati0.71706412
128MP0005389_reproductive_system_phenotype0.71232716
129MP0002080_prenatal_lethality0.70867934
130MP0003123_paternal_imprinting0.70679472
131MP0002697_abnormal_eye_size0.70625245
132MP0005647_abnormal_sex_gland0.70123644
133MP0009840_abnormal_foam_cell0.70015654
134MP0005084_abnormal_gallbladder_morpholo0.69474867
135MP0005508_abnormal_skeleton_morphology0.69425485
136MP0003959_abnormal_lean_body0.69087106
137MP0001727_abnormal_embryo_implantation0.68832061
138MP0005058_abnormal_lysosome_morphology0.68278990
139MP0004019_abnormal_vitamin_homeostasis0.68099849
140MP0000432_abnormal_head_morphology0.68044561
141MP0001348_abnormal_lacrimal_gland0.67931720
142MP0003861_abnormal_nervous_system0.67142838
143MP0002019_abnormal_tumor_incidence0.66425189
144MP0003111_abnormal_nucleus_morphology0.65699642
145MP0005220_abnormal_exocrine_pancreas0.65522010
146MP0005375_adipose_tissue_phenotype0.65188003
147MP0009643_abnormal_urine_homeostasis0.64767378
148MP0008770_decreased_survivor_rate0.63799171
149MP0000467_abnormal_esophagus_morphology0.63598534
150MP0003448_altered_tumor_morphology0.62406175
151MP0003303_peritoneal_inflammation0.61308882
152MP0010386_abnormal_urinary_bladder0.60944819
153MP0009384_cardiac_valve_regurgitation0.60233083
154MP0001905_abnormal_dopamine_level0.57463269
155MP0000678_abnormal_parathyroid_gland0.54539922
156MP0003091_abnormal_cell_migration0.53684116
157MP0002909_abnormal_adrenal_gland0.53496675
158MP0004858_abnormal_nervous_system0.53379145
159MP0003315_abnormal_perineum_morphology0.50395546
160MP0001191_abnormal_skin_condition0.49738858
161MP0001186_pigmentation_phenotype0.47990654
162MP0005377_hearing/vestibular/ear_phenot0.47976456
163MP0003878_abnormal_ear_physiology0.47976456
164MP0002210_abnormal_sex_determination0.47249300
165MP0002136_abnormal_kidney_physiology0.45776685
166MP0001970_abnormal_pain_threshold0.37575662
167MP0002933_joint_inflammation0.36381558
168MP0001216_abnormal_epidermal_layer0.35771864
169MP0005666_abnormal_adipose_tissue0.34702994
170MP0009333_abnormal_splenocyte_physiolog0.34462764
171MP0000759_abnormal_skeletal_muscle0.34391556

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)6.86284082
2Concave nail (HP:0001598)5.67530246
3Rib fusion (HP:0000902)5.26445143
4Turricephaly (HP:0000262)5.03802732
5Annular pancreas (HP:0001734)4.93924026
6Thin bony cortex (HP:0002753)4.91129444
7Dyschromatopsia (HP:0007641)4.89256277
8Facial hemangioma (HP:0000329)4.84131838
9Attenuation of retinal blood vessels (HP:0007843)4.77054234
10Coronal craniosynostosis (HP:0004440)4.68447351
11Increased IgM level (HP:0003496)4.61915840
12Mesangial abnormality (HP:0001966)4.43794089
13Popliteal pterygium (HP:0009756)4.27543639
14Alopecia of scalp (HP:0002293)4.27048092
15Ulnar bowing (HP:0003031)4.26338817
16Pustule (HP:0200039)4.25711518
17Hypochromic microcytic anemia (HP:0004840)4.24688990
18Rectal fistula (HP:0100590)4.19232346
19Rectovaginal fistula (HP:0000143)4.19232346
20Akinesia (HP:0002304)4.19131740
21Abnormality of the intrinsic pathway (HP:0010989)4.18881687
22Poikiloderma (HP:0001029)4.14031455
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.93098481
24Vaginal fistula (HP:0004320)3.78879377
25Intestinal fistula (HP:0100819)3.74352481
26Congenital stationary night blindness (HP:0007642)3.73003006
27Abnormal hemoglobin (HP:0011902)3.71014417
28Facial diplegia (HP:0001349)3.68962637
29Hemorrhage of the eye (HP:0011885)3.67698359
30Fetal akinesia sequence (HP:0001989)3.60096873
31Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.54810719
32Growth hormone excess (HP:0000845)3.54452633
33Aplasia/Hypoplasia of the patella (HP:0006498)3.49927180
34Alacrima (HP:0000522)3.49098738
35Anteriorly placed anus (HP:0001545)3.46494314
36Delayed epiphyseal ossification (HP:0002663)3.44656259
37Tongue fasciculations (HP:0001308)3.42825993
38Bony spicule pigmentary retinopathy (HP:0007737)3.34113037
39Short humerus (HP:0005792)3.32279741
40Orthostatic hypotension (HP:0001278)3.31752382
41Male infertility (HP:0003251)3.25556812
42Chorioretinal atrophy (HP:0000533)3.25553776
43Renal Fanconi syndrome (HP:0001994)3.24328182
44Short chin (HP:0000331)3.21681717
45Muscle fibrillation (HP:0010546)3.21587958
46Increased hepatocellular lipid droplets (HP:0006565)3.20165515
47Hypercortisolism (HP:0001578)3.20021038
48Prolonged partial thromboplastin time (HP:0003645)3.18336459
49Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.15733831
50Vertebral hypoplasia (HP:0008417)3.15733831
51Aplasia/hypoplasia of the humerus (HP:0006507)3.15474369
52Amniotic constriction ring (HP:0009775)3.11983735
53Abnormality of placental membranes (HP:0011409)3.11983735
54Joint hemorrhage (HP:0005261)3.11768556
55Abnormal albumin level (HP:0012116)3.10686642
56Hypoalbuminemia (HP:0003073)3.10686642
57Birth length less than 3rd percentile (HP:0003561)3.09886961
58Lipid accumulation in hepatocytes (HP:0006561)3.08781962
59Congenital hip dislocation (HP:0001374)3.08041906
60Choroideremia (HP:0001139)3.02321615
61Mucopolysacchariduria (HP:0008155)3.02099235
62Urinary glycosaminoglycan excretion (HP:0003541)3.02099235
63Intestinal atresia (HP:0011100)2.97587913
64Large for gestational age (HP:0001520)2.93362078
65Malnutrition (HP:0004395)2.91378835
66Polycythemia (HP:0001901)2.88426183
67Premature skin wrinkling (HP:0100678)2.88025748
68Abnormality of male internal genitalia (HP:0000022)2.86638136
69Atrioventricular block (HP:0001678)2.83251900
70Abnormality of the costochondral junction (HP:0000919)2.83227418
71Broad alveolar ridges (HP:0000187)2.82523783
72Abnormality of the aortic arch (HP:0012303)2.82173465
73Pancreatic islet-cell hyperplasia (HP:0004510)2.80892649
74Absent radius (HP:0003974)2.80021439
75Decreased electroretinogram (ERG) amplitude (HP:0000654)2.78127610
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.77332003
77Dysostosis multiplex (HP:0000943)2.75401386
78Basal cell carcinoma (HP:0002671)2.75292895
79Dysautonomia (HP:0002459)2.73760109
80Hamartoma (HP:0010566)2.71015285
81Squamous cell carcinoma (HP:0002860)2.69516461
82Enlarged epiphyses (HP:0010580)2.68770088
83Aplasia involving forearm bones (HP:0009822)2.68252077
84Absent forearm bone (HP:0003953)2.68252077
85Abnormality of glycosaminoglycan metabolism (HP:0004371)2.68191623
86Abnormality of mucopolysaccharide metabolism (HP:0011020)2.68191623
87Abnormality of polysaccharide metabolism (HP:0011012)2.68191623
88Choanal stenosis (HP:0000452)2.65470796
89Myotonia (HP:0002486)2.65417298
90Cerebral aneurysm (HP:0004944)2.64489628
91Decreased lacrimation (HP:0000633)2.63534505
92Clumsiness (HP:0002312)2.60475482
93Breast hypoplasia (HP:0003187)2.56385425
94Diaphragmatic weakness (HP:0009113)2.53397204
95Hypophosphatemic rickets (HP:0004912)2.50249379
96Joint stiffness (HP:0001387)2.47207104
97Hypokinesia (HP:0002375)2.46238397
98Bowing of the arm (HP:0006488)2.42110104
99Bowed forearm bones (HP:0003956)2.42110104
100Decreased central vision (HP:0007663)2.41607681
101Volvulus (HP:0002580)2.39200035
102Increased intramyocellular lipid droplets (HP:0012240)2.39036453
103Narrow nasal bridge (HP:0000446)2.36552378
104Selective tooth agenesis (HP:0001592)2.36519026
105Flat occiput (HP:0005469)2.36199927
106Aplasia/Hypoplasia involving the musculature (HP:0001460)2.36195666
107Increased muscle lipid content (HP:0009058)2.36090651
108Neonatal onset (HP:0003623)2.34312489
109Hypotrichosis (HP:0001006)2.34196096
110Absent thumb (HP:0009777)2.34097093
111Hypochromic anemia (HP:0001931)2.34048499
112Neonatal respiratory distress (HP:0002643)2.32559358
113Abnormality of the astrocytes (HP:0100707)2.31218200
114Astrocytoma (HP:0009592)2.31218200
115Widely patent fontanelles and sutures (HP:0004492)2.30146267
116Myopathic facies (HP:0002058)2.28263514
117Aplasia of the musculature (HP:0100854)2.27414717
118Vertebral fusion (HP:0002948)2.26663667
119Increased number of teeth (HP:0011069)2.26658549
120Hypotelorism (HP:0000601)2.25870531
121Thin ribs (HP:0000883)2.25405918
122Hyperparathyroidism (HP:0000843)2.24915858
123Albinism (HP:0001022)2.23149543
124Bifid uvula (HP:0000193)2.21219985
125Acute lymphatic leukemia (HP:0006721)2.20247838
126Split hand (HP:0001171)2.18282150
127Thickened helices (HP:0000391)2.17413332
128Pterygium (HP:0001059)2.17398805
129Short thumb (HP:0009778)2.17336540
130Abnormal epiphyseal ossification (HP:0010656)2.13191209
131Zonular cataract (HP:0010920)2.12900116
132Abnormality of the labia minora (HP:0012880)2.10845124
133Hypoplasia of the pons (HP:0012110)2.09222308
134Capillary hemangiomas (HP:0005306)2.08512921
135Tented upper lip vermilion (HP:0010804)2.08504522
136Lower limb hyperreflexia (HP:0002395)2.08125223
137Redundant skin (HP:0001582)2.07472882
138Generalized amyotrophy (HP:0003700)2.06838064
139Pendular nystagmus (HP:0012043)2.05450513
140Asymmetric septal hypertrophy (HP:0001670)2.05359900
141Bulbar palsy (HP:0001283)2.03469606
142Short 5th finger (HP:0009237)2.00933763
143Respiratory difficulties (HP:0002880)2.00211874
144Patellar aplasia (HP:0006443)1.99662795
145Exertional dyspnea (HP:0002875)1.98552993
146Diminished movement (HP:0002374)1.98247827
147Rectal prolapse (HP:0002035)1.96186483
148Congenital glaucoma (HP:0001087)1.94787890
149Cheilitis (HP:0100825)1.92655609
150Abnormal drinking behavior (HP:0030082)1.92304670
151Polydipsia (HP:0001959)1.92304670
152Reduced antithrombin III activity (HP:0001976)1.92128175
153Menstrual irregularities (HP:0000858)1.91978599
154Hypoplastic heart (HP:0001961)1.89064004
155Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.88944543
156Premature graying of hair (HP:0002216)1.88770121
157Abnormality of the periventricular white matter (HP:0002518)1.87360639
158Bilateral sensorineural hearing impairment (HP:0008619)1.84290378
159Progressive external ophthalmoplegia (HP:0000590)1.84230538
160Abnormal urine phosphate concentration (HP:0012599)1.84200189
161Generalized hyperpigmentation (HP:0007440)1.84190976
162Malignant hyperthermia (HP:0002047)1.84018600
163Abnormality of the lower motor neuron (HP:0002366)1.83937348
164Slender long bone (HP:0003100)1.83780945
165Abnormality of the pons (HP:0007361)1.82764312
166Epiphyseal stippling (HP:0010655)1.78043518

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.25898423
2DDR25.15191434
3MAPK154.79487137
4WNK44.36576134
5MAP3K64.27220196
6TYRO33.35258245
7MAP3K113.17499477
8ZAK3.07928912
9MUSK3.00540754
10PINK12.95694768
11FGR2.83137752
12UHMK12.77837424
13MATK2.68713003
14PDGFRA2.51848493
15BLK2.41211559
16TESK22.28925708
17BMX2.25977426
18PRKD22.21708912
19STK162.10530407
20DAPK12.10038887
21CSK2.07194118
22DYRK1B2.00562916
23PIM21.95401631
24ERN11.87537877
25GRK61.84639145
26LATS21.83474968
27YES11.83052346
28IRAK21.70503044
29MAP2K31.56552164
30CDK71.51520702
31PDK21.45829353
32EEF2K1.44872962
33PHKG21.43484588
34PHKG11.43484588
35TRIB31.40191988
36SMG11.38444680
37PDPK11.34701831
38MST1R1.34241924
39TRPM71.33097420
40CDK41.32316008
41CDK61.25343479
42AKT31.21524003
43MAP3K101.21421973
44IRAK31.18168381
45NEK21.17986991
46CCNB11.16995772
47GSK3A1.16837721
48ADRBK11.15886913
49EPHA21.14559084
50RPS6KL11.12597190
51RPS6KC11.12597190
52CDC42BPA1.12536743
53PKN21.11140846
54NME21.10773641
55DYRK31.07490282
56MAPK111.04586701
57PIM11.04500746
58MAP2K61.01183841
59PRPF4B0.99793245
60ADRBK20.98712962
61RPS6KA60.94894961
62RPS6KA20.90589831
63CHEK20.89489887
64MAPK120.89053275
65RPS6KA50.84183342
66TAOK20.83294194
67BCKDK0.82086273
68ACVR1B0.79131797
69ARAF0.78558870
70CSNK1G10.77851477
71STK390.76980268
72TBK10.74438708
73DYRK20.74383530
74MTOR0.72858442
75WNK10.72397905
76MAP3K90.70893932
77HIPK20.70416861
78ZAP700.63499918
79PRKAA10.63388675
80PDGFRB0.62432742
81STK110.60460665
82RPS6KA10.60228150
83PAK60.59759339
84MELK0.58084240
85NTRK20.57406899
86CAMK2G0.54933797
87CAMK2B0.54649730
88IKBKB0.54266521
89SIK20.52397764
90RIPK10.51624824
91PLK10.48329653
92CSNK1G30.47547464
93ALK0.47496678
94EGFR0.46057127
95EPHB20.45683379
96MARK20.44442476
97TNK20.43960762
98MAPK80.41838302
99MAPK40.40001264
100TAOK10.39257266
101MAP2K20.38913493
102PRKD10.37715374
103CSNK1D0.37443045
104PAK20.37156850
105PRKCZ0.36903798
106SIK10.36536495
107CDK20.36276181
108RAF10.35132817
109MAP4K10.35095376
110CAMK2D0.35084697
111CDK150.34883570
112DAPK30.34630830
113CAMK2A0.34167609
114CDK11A0.33114342
115ERBB30.32896666
116TTN0.32781224
117AURKA0.32632931
118CDK80.31422603
119RPS6KB10.30968458
120DMPK0.30961770
121CDK180.30822058
122PTK20.30282655
123MAPK10.30005122
124CSNK1G20.29540913
125BRAF0.29478393
126PRKAA20.28729500
127OXSR10.28427622
128MAPK100.28274278
129MAP2K40.28003196
130INSR0.27771908
131TLK10.26847249
132RPS6KB20.26358972
133CAMKK10.26324500
134DAPK20.25878257
135BMPR1B0.25825822
136MAPK30.25744685
137CDK140.25122311
138MARK10.25017848
139PRKCI0.24936649
140CSNK2A10.24267583
141MET0.24170118
142MAPK140.23796984
143ABL20.23561513
144PAK10.23397824
145CSNK1A1L0.22481512
146ATR0.22356754
147PTK60.21902740
148LYN0.21625701
149PKN10.21142714
150CHUK0.20088411
151AKT20.20009808
152CHEK10.18593112
153PDK10.18456841
154PRKD30.18368212
155RPS6KA30.17986101
156FGFR10.17364424
157CDK10.17191850
158MAPK90.16953830
159CSNK2A20.16602125

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006047.04707294
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001306.01266318
3Fatty acid biosynthesis_Homo sapiens_hsa000615.97815621
4Base excision repair_Homo sapiens_hsa034104.09375015
5Mismatch repair_Homo sapiens_hsa034303.89774599
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.09608717
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.92459178
8Sulfur relay system_Homo sapiens_hsa041222.92015641
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.79057967
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.67470877
11Arginine and proline metabolism_Homo sapiens_hsa003302.47027723
12DNA replication_Homo sapiens_hsa030302.44582972
13Hedgehog signaling pathway_Homo sapiens_hsa043402.21738931
14mTOR signaling pathway_Homo sapiens_hsa041502.08304652
15Hippo signaling pathway_Homo sapiens_hsa043902.08105442
16Notch signaling pathway_Homo sapiens_hsa043302.02989948
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.02476095
18Biosynthesis of amino acids_Homo sapiens_hsa012301.98375587
19Sphingolipid metabolism_Homo sapiens_hsa006001.91449233
20Fatty acid metabolism_Homo sapiens_hsa012121.85451309
21Arginine biosynthesis_Homo sapiens_hsa002201.67640504
22Bladder cancer_Homo sapiens_hsa052191.64552119
23mRNA surveillance pathway_Homo sapiens_hsa030151.63042290
24Circadian rhythm_Homo sapiens_hsa047101.60467375
25Basal cell carcinoma_Homo sapiens_hsa052171.55510765
26Folate biosynthesis_Homo sapiens_hsa007901.50466980
27Adherens junction_Homo sapiens_hsa045201.40668499
28Wnt signaling pathway_Homo sapiens_hsa043101.39957876
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.38869414
30Lysine degradation_Homo sapiens_hsa003101.36849936
31Longevity regulating pathway - mammal_Homo sapiens_hsa042111.36028115
32Nucleotide excision repair_Homo sapiens_hsa034201.35494194
33TGF-beta signaling pathway_Homo sapiens_hsa043501.30282884
34Other glycan degradation_Homo sapiens_hsa005111.23393089
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19330791
36Spliceosome_Homo sapiens_hsa030401.14248604
37Gap junction_Homo sapiens_hsa045401.14227135
38Vitamin digestion and absorption_Homo sapiens_hsa049771.07539425
39VEGF signaling pathway_Homo sapiens_hsa043701.04899630
40RNA polymerase_Homo sapiens_hsa030201.04674774
41Colorectal cancer_Homo sapiens_hsa052101.03760876
42Alcoholism_Homo sapiens_hsa050341.01770753
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01092423
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99294295
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98696499
46RNA transport_Homo sapiens_hsa030130.97520786
47Choline metabolism in cancer_Homo sapiens_hsa052310.97337528
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96817455
49p53 signaling pathway_Homo sapiens_hsa041150.93254435
50Fanconi anemia pathway_Homo sapiens_hsa034600.93048687
51ErbB signaling pathway_Homo sapiens_hsa040120.91432190
52Systemic lupus erythematosus_Homo sapiens_hsa053220.91022997
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89780068
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89207529
55Shigellosis_Homo sapiens_hsa051310.88540633
56Taste transduction_Homo sapiens_hsa047420.88478975
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88356989
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85368248
59Pyrimidine metabolism_Homo sapiens_hsa002400.83373523
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.81419060
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80036400
62Lysosome_Homo sapiens_hsa041420.79388064
63One carbon pool by folate_Homo sapiens_hsa006700.78848808
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77403632
65Chronic myeloid leukemia_Homo sapiens_hsa052200.76285920
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74685376
67Nitrogen metabolism_Homo sapiens_hsa009100.74420074
68Inositol phosphate metabolism_Homo sapiens_hsa005620.71054038
69Oocyte meiosis_Homo sapiens_hsa041140.70478204
70MicroRNAs in cancer_Homo sapiens_hsa052060.69357079
71Homologous recombination_Homo sapiens_hsa034400.69207293
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68947812
73Ovarian steroidogenesis_Homo sapiens_hsa049130.68046913
74Insulin signaling pathway_Homo sapiens_hsa049100.66640430
75Dorso-ventral axis formation_Homo sapiens_hsa043200.66545341
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65113652
77Tight junction_Homo sapiens_hsa045300.64672381
78Fructose and mannose metabolism_Homo sapiens_hsa000510.64651668
79N-Glycan biosynthesis_Homo sapiens_hsa005100.64431835
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.64143084
81Endometrial cancer_Homo sapiens_hsa052130.63425311
82Steroid biosynthesis_Homo sapiens_hsa001000.62222929
83Viral myocarditis_Homo sapiens_hsa054160.62149982
84AMPK signaling pathway_Homo sapiens_hsa041520.61977431
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61491708
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61469079
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58667033
88Acute myeloid leukemia_Homo sapiens_hsa052210.57856352
89Selenocompound metabolism_Homo sapiens_hsa004500.57034093
90Glycerolipid metabolism_Homo sapiens_hsa005610.55060273
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53498153
92Cell cycle_Homo sapiens_hsa041100.53360686
93Pyruvate metabolism_Homo sapiens_hsa006200.52012563
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49110889
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.48014267
96Long-term depression_Homo sapiens_hsa047300.47469264
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.46012259
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45631031
99Calcium signaling pathway_Homo sapiens_hsa040200.45528132
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.44957390
101Thyroid cancer_Homo sapiens_hsa052160.44082198
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42843613
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41046201
104Nicotine addiction_Homo sapiens_hsa050330.41021253
105Cocaine addiction_Homo sapiens_hsa050300.40893572
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39655946
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38841115
108Estrogen signaling pathway_Homo sapiens_hsa049150.38720985
109Proteoglycans in cancer_Homo sapiens_hsa052050.38443683
110Insulin resistance_Homo sapiens_hsa049310.38135931
111Glutathione metabolism_Homo sapiens_hsa004800.37075278
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.37012741
113Basal transcription factors_Homo sapiens_hsa030220.36094810
114Metabolic pathways_Homo sapiens_hsa011000.35517945
115Fatty acid elongation_Homo sapiens_hsa000620.34947813
116MAPK signaling pathway_Homo sapiens_hsa040100.33555390
117Small cell lung cancer_Homo sapiens_hsa052220.33388468
118GnRH signaling pathway_Homo sapiens_hsa049120.32891184
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.32450249
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.30217624
121Melanogenesis_Homo sapiens_hsa049160.30208756
122Focal adhesion_Homo sapiens_hsa045100.30079955
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29451211
124Fat digestion and absorption_Homo sapiens_hsa049750.28600008
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26587279
126Axon guidance_Homo sapiens_hsa043600.25797635
127Vitamin B6 metabolism_Homo sapiens_hsa007500.25712592
128Viral carcinogenesis_Homo sapiens_hsa052030.25661670
129Cardiac muscle contraction_Homo sapiens_hsa042600.25563671
130Bile secretion_Homo sapiens_hsa049760.24449077
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24287805
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22666217
133Sulfur metabolism_Homo sapiens_hsa009200.22007399
134Pathways in cancer_Homo sapiens_hsa052000.21484913
135Non-small cell lung cancer_Homo sapiens_hsa052230.21223994
136Glioma_Homo sapiens_hsa052140.21012059
137Glucagon signaling pathway_Homo sapiens_hsa049220.20634001
138Endocytosis_Homo sapiens_hsa041440.20546422
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.20302441
140Purine metabolism_Homo sapiens_hsa002300.19954583
141Ribosome_Homo sapiens_hsa030100.19808824
142Phenylalanine metabolism_Homo sapiens_hsa003600.17773401
143RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17510247
144Hepatitis C_Homo sapiens_hsa051600.16754304
145HTLV-I infection_Homo sapiens_hsa051660.14954295
146Galactose metabolism_Homo sapiens_hsa000520.14949780
147Melanoma_Homo sapiens_hsa052180.14798314
148Phototransduction_Homo sapiens_hsa047440.13363073
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10245621
150Chemical carcinogenesis_Homo sapiens_hsa052040.09603942
151Steroid hormone biosynthesis_Homo sapiens_hsa001400.09096898
152Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.08301733
153Drug metabolism - other enzymes_Homo sapiens_hsa009830.07446247

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