TIGD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)5.38741736
2male meiosis I (GO:0007141)4.64776483
3piRNA metabolic process (GO:0034587)4.56639308
4positive regulation of mitochondrial fission (GO:0090141)4.56414928
5proteasome assembly (GO:0043248)4.53991936
6RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.04393892
7tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.04393892
8meiosis I (GO:0007127)3.94679580
9nonmotile primary cilium assembly (GO:0035058)3.89947008
10protein K6-linked ubiquitination (GO:0085020)3.76698269
11DNA methylation involved in gamete generation (GO:0043046)3.70257486
12chromosome organization involved in meiosis (GO:0070192)3.69275790
13kynurenine metabolic process (GO:0070189)3.48384144
14replication fork processing (GO:0031297)3.44834893
15pyrimidine dimer repair (GO:0006290)3.41069507
16resolution of meiotic recombination intermediates (GO:0000712)3.39958146
17ubiquinone biosynthetic process (GO:0006744)3.35450189
18endosome to melanosome transport (GO:0035646)3.32892774
19endosome to pigment granule transport (GO:0043485)3.32892774
20cullin deneddylation (GO:0010388)3.27452770
21protein deneddylation (GO:0000338)3.21004160
22regulation of cilium movement (GO:0003352)3.20990664
23rRNA catabolic process (GO:0016075)3.18927586
24C-terminal protein lipidation (GO:0006501)3.18382381
25photoreceptor cell maintenance (GO:0045494)3.09782537
26intraciliary transport (GO:0042073)3.04296146
27coenzyme catabolic process (GO:0009109)3.04165028
28male meiosis (GO:0007140)3.02774289
29mitochondrial respiratory chain complex I assembly (GO:0032981)2.99601068
30NADH dehydrogenase complex assembly (GO:0010257)2.99601068
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99601068
32response to pheromone (GO:0019236)2.99560106
33ubiquinone metabolic process (GO:0006743)2.97597218
34preassembly of GPI anchor in ER membrane (GO:0016254)2.96596974
35regulation of mitochondrial fission (GO:0090140)2.95445830
36mannosylation (GO:0097502)2.94342235
37L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.93891223
38branched-chain amino acid catabolic process (GO:0009083)2.92285580
39DNA synthesis involved in DNA repair (GO:0000731)2.92059434
40chaperone-mediated protein complex assembly (GO:0051131)2.87607869
41oligosaccharide catabolic process (GO:0009313)2.83816470
42protein K11-linked ubiquitination (GO:0070979)2.83650119
43mitochondrial RNA metabolic process (GO:0000959)2.82483906
44C-terminal protein amino acid modification (GO:0018410)2.81374893
45peroxisome fission (GO:0016559)2.80271191
46peptidyl-histidine modification (GO:0018202)2.78676534
47magnesium ion transport (GO:0015693)2.78623552
48meiotic nuclear division (GO:0007126)2.77763518
49synaptonemal complex assembly (GO:0007130)2.77572244
50pseudouridine synthesis (GO:0001522)2.76562301
51tryptophan metabolic process (GO:0006568)2.75337865
52indole-containing compound catabolic process (GO:0042436)2.74443110
53indolalkylamine catabolic process (GO:0046218)2.74443110
54tryptophan catabolic process (GO:0006569)2.74443110
55base-excision repair, AP site formation (GO:0006285)2.73469703
56maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.71979623
57iron-sulfur cluster assembly (GO:0016226)2.69791388
58metallo-sulfur cluster assembly (GO:0031163)2.69791388
59anterograde synaptic vesicle transport (GO:0048490)2.69499825
60meiotic cell cycle process (GO:1903046)2.67668631
61double-strand break repair via homologous recombination (GO:0000724)2.66192908
62quinone biosynthetic process (GO:1901663)2.66032591
63regulation of mitochondrial translation (GO:0070129)2.65846829
64ribonucleoprotein complex disassembly (GO:0032988)2.63797650
65recombinational repair (GO:0000725)2.63321926
66synaptonemal complex organization (GO:0070193)2.62667396
67negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.62472634
68reciprocal meiotic recombination (GO:0007131)2.62431874
69reciprocal DNA recombination (GO:0035825)2.62431874
70DNA double-strand break processing (GO:0000729)2.61828534
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60287806
72mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.57720604
73positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.57720604
74platelet dense granule organization (GO:0060155)2.57350913
75pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.56743817
767-methylguanosine mRNA capping (GO:0006370)2.56574471
77rRNA methylation (GO:0031167)2.54208762
78tRNA processing (GO:0008033)2.51729126
79regulation of microtubule-based movement (GO:0060632)2.51385065
80attachment of spindle microtubules to kinetochore (GO:0008608)2.51273556
81cilium morphogenesis (GO:0060271)2.51125911
82cilium assembly (GO:0042384)2.50980238
83DNA replication checkpoint (GO:0000076)2.50814992
84rRNA modification (GO:0000154)2.50600303
85cilium organization (GO:0044782)2.50162696
86protein complex biogenesis (GO:0070271)2.49190163
87facial nerve structural organization (GO:0021612)2.49161998
88L-methionine salvage (GO:0071267)2.49136553
89L-methionine biosynthetic process (GO:0071265)2.49136553
90amino acid salvage (GO:0043102)2.49136553
91centriole replication (GO:0007099)2.48980186
92acrosome reaction (GO:0007340)2.48606250
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.47808412
94nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.47327870
957-methylguanosine RNA capping (GO:0009452)2.47320798
96RNA capping (GO:0036260)2.47320798
97water-soluble vitamin biosynthetic process (GO:0042364)2.45712859
98inositol metabolic process (GO:0006020)2.44777643
99purine-containing compound salvage (GO:0043101)2.41880242
100positive regulation of prostaglandin secretion (GO:0032308)2.41399788

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.40500778
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.06216426
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.70418361
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.67474223
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.57437455
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.52106242
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.26374981
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.21247109
9PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.95892426
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.76225929
11* ELK1_19687146_ChIP-ChIP_HELA_Human2.71787752
12VDR_23849224_ChIP-Seq_CD4+_Human2.70136833
13ZNF274_21170338_ChIP-Seq_K562_Hela2.65833356
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.62725744
15DCP1A_22483619_ChIP-Seq_HELA_Human2.45876461
16FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.45087002
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.35795187
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34216506
19* GABP_19822575_ChIP-Seq_HepG2_Human2.33226026
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.18767611
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11980683
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11539674
23PADI4_21655091_ChIP-ChIP_MCF-7_Human2.07985507
24FOXP3_21729870_ChIP-Seq_TREG_Human2.01061017
25EWS_26573619_Chip-Seq_HEK293_Human1.94706950
26IGF1R_20145208_ChIP-Seq_DFB_Human1.84896656
27KDM5A_27292631_Chip-Seq_BREAST_Human1.80599678
28YY1_21170310_ChIP-Seq_MESCs_Mouse1.79845336
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.74793949
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72706641
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69297869
32VDR_22108803_ChIP-Seq_LS180_Human1.68199458
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67699389
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.66488940
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64981730
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.61068776
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59381613
38* TTF2_22483619_ChIP-Seq_HELA_Human1.58899869
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57879370
40GBX2_23144817_ChIP-Seq_PC3_Human1.55289803
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.54612924
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53655639
43TFEB_21752829_ChIP-Seq_HELA_Human1.52014804
44MYC_18940864_ChIP-ChIP_HL60_Human1.51915917
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.49425727
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45674862
47XRN2_22483619_ChIP-Seq_HELA_Human1.43158949
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41294920
49CIITA_25753668_ChIP-Seq_RAJI_Human1.41036193
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40414077
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34951123
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.34508355
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32758214
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32757401
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29117380
56E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25759497
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24983286
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24857915
59TP53_22573176_ChIP-Seq_HFKS_Human1.24655186
60ER_23166858_ChIP-Seq_MCF-7_Human1.19293300
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.16155419
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15509639
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13928604
64SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11549891
65FUS_26573619_Chip-Seq_HEK293_Human1.09947534
66MYC_19030024_ChIP-ChIP_MESCs_Mouse1.07007694
67PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06829835
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04028644
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03623350
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03133054
71E2F7_22180533_ChIP-Seq_HELA_Human1.01039372
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00045607
73CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98861824
74CBP_20019798_ChIP-Seq_JUKART_Human0.98775523
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98775523
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98640790
77ELK1_22589737_ChIP-Seq_MCF10A_Human0.95445550
78CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95290042
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93710353
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93037229
81AR_20517297_ChIP-Seq_VCAP_Human0.91680834
82FLI1_27457419_Chip-Seq_LIVER_Mouse0.91581242
83CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91167531
84ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.91009799
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90534776
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89348749
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89057675
88RNF2_27304074_Chip-Seq_NSC_Mouse0.83416514
89TAF15_26573619_Chip-Seq_HEK293_Human0.83199526
90IRF1_19129219_ChIP-ChIP_H3396_Human0.81326837
91CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.80655269
92PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79490473
93HTT_18923047_ChIP-ChIP_STHdh_Human0.78089527
94GATA4_21415370_ChIP-Seq_HL-1_Mouse0.77911971
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77859127
96CTBP1_25329375_ChIP-Seq_LNCAP_Human0.77033709
97STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.76097706
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.75678388
99* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.74993979
100KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.74629848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.51296919
2MP0008058_abnormal_DNA_repair3.96822330
3MP0009697_abnormal_copulation2.64652678
4MP0003186_abnormal_redox_activity2.53394063
5MP0002160_abnormal_reproductive_system2.50099522
6MP0002090_abnormal_vision2.36334333
7MP0002102_abnormal_ear_morphology2.30826093
8MP0003718_maternal_effect2.24696141
9MP0009046_muscle_twitch2.23723109
10MP0008875_abnormal_xenobiotic_pharmacok2.13849745
11MP0006072_abnormal_retinal_apoptosis2.11049872
12MP0003136_yellow_coat_color2.09847297
13MP0006276_abnormal_autonomic_nervous2.09751363
14MP0000358_abnormal_cell_content/2.04804246
15MP0000427_abnormal_hair_cycle1.94938697
16MP0005253_abnormal_eye_physiology1.91814433
17MP0006035_abnormal_mitochondrial_morpho1.88323531
18MP0005551_abnormal_eye_electrophysiolog1.86655620
19MP0002638_abnormal_pupillary_reflex1.84742569
20MP0001542_abnormal_bone_strength1.81808194
21MP0002837_dystrophic_cardiac_calcinosis1.81393924
22MP0000647_abnormal_sebaceous_gland1.81365584
23MP0002210_abnormal_sex_determination1.76124992
24MP0004142_abnormal_muscle_tone1.75975024
25MP0005367_renal/urinary_system_phenotyp1.64839682
26MP0000516_abnormal_urinary_system1.64839682
27MP0001764_abnormal_homeostasis1.64545894
28MP0001929_abnormal_gametogenesis1.62122176
29MP0002653_abnormal_ependyma_morphology1.60670725
30MP0003786_premature_aging1.59666457
31MP0005389_reproductive_system_phenotype1.58824371
32MP0009764_decreased_sensitivity_to1.58619873
33MP0004233_abnormal_muscle_weight1.57460232
34MP0010094_abnormal_chromosome_stability1.56715592
35MP0006054_spinal_hemorrhage1.56528792
36MP0002095_abnormal_skin_pigmentation1.49276125
37MP0001968_abnormal_touch/_nociception1.45201452
38MP0008789_abnormal_olfactory_epithelium1.41126284
39MP0005394_taste/olfaction_phenotype1.40444550
40MP0005499_abnormal_olfactory_system1.40444550
41MP0003806_abnormal_nucleotide_metabolis1.40165350
42MP0003941_abnormal_skin_development1.35969266
43MP0000653_abnormal_sex_gland1.35592609
44MP0003111_abnormal_nucleus_morphology1.32183710
45MP0001145_abnormal_male_reproductive1.31559496
46MP0008932_abnormal_embryonic_tissue1.31268736
47MP0005646_abnormal_pituitary_gland1.30334567
48MP0003698_abnormal_male_reproductive1.26311414
49MP0004043_abnormal_pH_regulation1.25214240
50MP0005410_abnormal_fertilization1.23581782
51MP0000371_diluted_coat_color1.20914214
52MP0005647_abnormal_sex_gland1.19889923
53MP0003172_abnormal_lysosome_physiology1.19377932
54MP0005084_abnormal_gallbladder_morpholo1.18217168
55MP0003121_genomic_imprinting1.18178136
56MP0005171_absent_coat_pigmentation1.15931657
57MP0006036_abnormal_mitochondrial_physio1.15804768
58MP0005248_abnormal_Harderian_gland1.14542217
59MP0005058_abnormal_lysosome_morphology1.14164437
60MP0001324_abnormal_eye_pigmentation1.12668789
61MP0000372_irregular_coat_pigmentation1.09676923
62MP0003195_calcinosis1.07445049
63MP0000383_abnormal_hair_follicle1.06634354
64MP0000569_abnormal_digit_pigmentation0.96871147
65MP0005391_vision/eye_phenotype0.96648460
66MP0003693_abnormal_embryo_hatching0.96480234
67MP0001545_abnormal_hematopoietic_system0.96474303
68MP0005397_hematopoietic_system_phenotyp0.96474303
69MP0001119_abnormal_female_reproductive0.94081612
70MP0001919_abnormal_reproductive_system0.93212422
71MP0005319_abnormal_enzyme/_coenzyme0.92369447
72MP0005075_abnormal_melanosome_morpholog0.92251797
73MP0002751_abnormal_autonomic_nervous0.92164502
74MP0008007_abnormal_cellular_replicative0.91084893
75MP0000631_abnormal_neuroendocrine_gland0.90843834
76MP0002332_abnormal_exercise_endurance0.90068552
77MP0005645_abnormal_hypothalamus_physiol0.87829034
78MP0002938_white_spotting0.86863686
79MP0010386_abnormal_urinary_bladder0.85751806
80MP0002067_abnormal_sensory_capabilities0.85466826
81MP0009840_abnormal_foam_cell0.83085251
82MP0008961_abnormal_basal_metabolism0.79257973
83MP0005266_abnormal_metabolism0.77971849
84MP0002229_neurodegeneration0.76396093
85MP0003283_abnormal_digestive_organ0.73102962
86MP0001529_abnormal_vocalization0.72621069
87MP0002822_catalepsy0.72565460
88MP0005408_hypopigmentation0.72494281
89MP0002733_abnormal_thermal_nociception0.72221247
90MP0004185_abnormal_adipocyte_glucose0.71804498
91MP0003077_abnormal_cell_cycle0.71403169
92MP0004957_abnormal_blastocyst_morpholog0.70202771
93MP0009765_abnormal_xenobiotic_induced0.70142519
94MP0005310_abnormal_salivary_gland0.69978292
95MP0002970_abnormal_white_adipose0.69417239
96MP0001486_abnormal_startle_reflex0.67847835
97MP0003011_delayed_dark_adaptation0.67547158
98MP0002161_abnormal_fertility/fecundity0.67539940
99MP0000749_muscle_degeneration0.67450380
100MP0010678_abnormal_skin_adnexa0.67163520

Predicted human phenotypes

RankGene SetZ-score
1Medial flaring of the eyebrow (HP:0010747)4.65707088
2Congenital primary aphakia (HP:0007707)3.90361961
3Gait imbalance (HP:0002141)3.75899884
4Nephrogenic diabetes insipidus (HP:0009806)3.74377462
5True hermaphroditism (HP:0010459)3.34052628
6Pancreatic fibrosis (HP:0100732)3.27933949
7Aplasia/Hypoplasia of the tibia (HP:0005772)3.20155656
8Hepatic necrosis (HP:0002605)3.19046077
9Hepatocellular necrosis (HP:0001404)3.16194466
10Short tibia (HP:0005736)3.14343224
11Mitochondrial inheritance (HP:0001427)3.08668559
12Increased CSF lactate (HP:0002490)3.04476744
13Pancreatic cysts (HP:0001737)2.89931761
14Molar tooth sign on MRI (HP:0002419)2.87756694
15Abnormality of midbrain morphology (HP:0002418)2.87756694
16Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.79885676
17Degeneration of the lateral corticospinal tracts (HP:0002314)2.79885676
18Aplasia/Hypoplasia of the lens (HP:0008063)2.75252064
19Acute necrotizing encephalopathy (HP:0006965)2.63212244
20Attenuation of retinal blood vessels (HP:0007843)2.62367401
21Nephronophthisis (HP:0000090)2.61865938
22Congenital hepatic fibrosis (HP:0002612)2.60682162
23Vacuolated lymphocytes (HP:0001922)2.60353913
24Entropion (HP:0000621)2.59459982
25Abnormality of the labia minora (HP:0012880)2.58233966
26Poor coordination (HP:0002370)2.51922146
27Genital tract atresia (HP:0001827)2.50921129
28Abnormal protein glycosylation (HP:0012346)2.49436732
29Abnormal glycosylation (HP:0012345)2.49436732
30Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.49436732
31Abnormal protein N-linked glycosylation (HP:0012347)2.49436732
32Poikiloderma (HP:0001029)2.47514976
33Lactic acidosis (HP:0003128)2.46272183
34Acute encephalopathy (HP:0006846)2.44353536
35Ketosis (HP:0001946)2.43544190
36Polyphagia (HP:0002591)2.42631046
37Large eyes (HP:0001090)2.41403717
38Aplasia/Hypoplasia of the tongue (HP:0010295)2.39996959
39Vaginal atresia (HP:0000148)2.39795397
403-Methylglutaconic aciduria (HP:0003535)2.37406232
41Abnormal mitochondria in muscle tissue (HP:0008316)2.33925449
42Chromsome breakage (HP:0040012)2.33275392
43Degeneration of anterior horn cells (HP:0002398)2.28240005
44Abnormality of the anterior horn cell (HP:0006802)2.28240005
45Increased serum lactate (HP:0002151)2.26340896
46Sclerocornea (HP:0000647)2.25490781
47Renal cortical cysts (HP:0000803)2.25356159
48Hypokinesia (HP:0002375)2.22808468
49Methylmalonic aciduria (HP:0012120)2.21073367
50Astigmatism (HP:0000483)2.19038737
51Tubulointerstitial nephritis (HP:0001970)2.18104056
52Abnormality of macular pigmentation (HP:0008002)2.17809224
53Postaxial foot polydactyly (HP:0001830)2.17176284
54Microvesicular hepatic steatosis (HP:0001414)2.14657083
55Retinal dysplasia (HP:0007973)2.14598123
56CNS demyelination (HP:0007305)2.13190147
57Decreased testicular size (HP:0008734)2.12616263
58Renal Fanconi syndrome (HP:0001994)2.11479991
59Abnormality of glycosphingolipid metabolism (HP:0004343)2.10844565
60Abnormality of glycolipid metabolism (HP:0010969)2.10844565
61Abnormality of liposaccharide metabolism (HP:0010968)2.10844565
62Occipital encephalocele (HP:0002085)2.10355602
63Lipid accumulation in hepatocytes (HP:0006561)2.09860228
64Postaxial hand polydactyly (HP:0001162)2.06855370
65Abnormality of the renal medulla (HP:0100957)2.06543275
66Abnormality of the corticospinal tract (HP:0002492)2.06521719
67Prominent nasal bridge (HP:0000426)2.05911210
68Progressive macrocephaly (HP:0004481)2.04764216
69Broad foot (HP:0001769)2.02529657
70Albinism (HP:0001022)2.01126808
71Poor head control (HP:0002421)2.00734261
72Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99228782
73Pachygyria (HP:0001302)1.98801785
74Polymicrogyria (HP:0002126)1.98132248
75Sloping forehead (HP:0000340)1.97528456
76Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96724242
77Progressive microcephaly (HP:0000253)1.95879039
78Aganglionic megacolon (HP:0002251)1.93961030
79Specific learning disability (HP:0001328)1.92958992
80Anencephaly (HP:0002323)1.92766235
81Metabolic acidosis (HP:0001942)1.92751052
82Ketoacidosis (HP:0001993)1.92182658
83Abnormality of the renal cortex (HP:0011035)1.91492083
84Oculomotor apraxia (HP:0000657)1.90617415
85Dicarboxylic aciduria (HP:0003215)1.87590557
86Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87590557
87Loss of speech (HP:0002371)1.87505363
88Microretrognathia (HP:0000308)1.87212187
89Type I transferrin isoform profile (HP:0003642)1.86666523
90Progressive inability to walk (HP:0002505)1.86416240
91Abnormal rod and cone electroretinograms (HP:0008323)1.86063812
92Gaze-evoked nystagmus (HP:0000640)1.85146674
93Thyroid-stimulating hormone excess (HP:0002925)1.84560466
94Abnormality of DNA repair (HP:0003254)1.81875837
95Increased hepatocellular lipid droplets (HP:0006565)1.80345769
96Central scotoma (HP:0000603)1.80017604
97Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80007291
98Aplastic anemia (HP:0001915)1.79553360
99Optic disc pallor (HP:0000543)1.76737323
100Median cleft lip (HP:0000161)1.75906495

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K73.59782528
2VRK22.80062833
3IRAK32.77591793
4STK38L2.72984904
5STK162.68691747
6BMPR1B2.63502502
7BUB12.42782462
8AKT32.35730529
9TRIM282.31621292
10MAP4K22.31611441
11NUAK12.25110589
12MAP3K42.24577425
13ADRBK22.14664163
14PBK2.01087346
15BCKDK1.99137963
16CSNK1G31.90813826
17CSNK1A1L1.88962106
18FRK1.82746032
19SRPK11.79951992
20CDK81.75873525
21PNCK1.71724676
22VRK11.67978150
23PDK21.67420919
24PIM21.61159363
25BCR1.57790836
26CSNK1G21.52773921
27CSNK1G11.42495921
28GRK11.41834673
29DYRK31.41731739
30NEK11.41049077
31ACVR1B1.38730684
32ERBB31.38338743
33EIF2AK31.33504438
34PINK11.31174902
35TAOK31.30299697
36RPS6KA41.28175596
37CDK191.28117794
38FER1.28082515
39CDK91.16500111
40PRKD21.14392892
41WNK31.13585203
42NEK91.08483098
43PLK41.06633072
44GRK71.02994441
45CCNB11.02219757
46TAF10.97096707
47PLK10.97040281
48PRKCE0.93669783
49BRD40.87902704
50PLK20.87537599
51CDC70.86566268
52NME20.86438438
53CHEK20.86405740
54CDK30.84612845
55TESK20.80452802
56TGFBR10.80060754
57ATR0.79305341
58MAPK130.77970384
59ABL20.77396024
60IKBKB0.75927431
61ERN10.68273730
62MKNK20.67614697
63RPS6KA50.67535863
64WEE10.66781691
65PKN10.66732839
66AURKA0.66512223
67BMPR20.65759059
68NEK20.59183962
69PRKCI0.58556282
70STK380.58551865
71PRKCG0.57581355
72TNIK0.57357657
73ATM0.55582035
74TTK0.55208193
75CAMK1G0.53568534
76TESK10.53080810
77CAMK1D0.51611939
78EIF2AK10.50153967
79TNK20.49450102
80LIMK10.47947748
81BRSK20.46034940
82CSNK2A10.45800166
83CHUK0.45306267
84PRKD30.44028609
85SIK30.42261722
86ADRBK10.39952414
87MKNK10.39364467
88BRAF0.38347536
89DYRK20.38322721
90CSNK1A10.38303081
91EPHB20.36537809
92MAPKAPK50.35649360
93MARK30.35360308
94CDK60.33634055
95ERBB40.32257978
96CSNK2A20.31966964
97CDK70.29770176
98PTK2B0.29543311
99CHEK10.28989756
100KSR10.28778039

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030502.80881932
2Sulfur metabolism_Homo sapiens_hsa009202.68175889
3Homologous recombination_Homo sapiens_hsa034402.61265058
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.54045060
5Butanoate metabolism_Homo sapiens_hsa006502.51894566
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39632946
7Propanoate metabolism_Homo sapiens_hsa006402.36035716
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.27471346
9Fanconi anemia pathway_Homo sapiens_hsa034602.24766463
10Oxidative phosphorylation_Homo sapiens_hsa001902.23064810
11Sulfur relay system_Homo sapiens_hsa041222.18447780
12Steroid biosynthesis_Homo sapiens_hsa001002.10732522
13Protein export_Homo sapiens_hsa030602.09190732
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.08704119
15Basal transcription factors_Homo sapiens_hsa030222.03946782
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.03465076
17beta-Alanine metabolism_Homo sapiens_hsa004101.98742988
18RNA polymerase_Homo sapiens_hsa030201.96886024
19Selenocompound metabolism_Homo sapiens_hsa004501.95918828
20Nucleotide excision repair_Homo sapiens_hsa034201.89417526
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83583285
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80760202
23Parkinsons disease_Homo sapiens_hsa050121.75039544
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.62283135
25Huntingtons disease_Homo sapiens_hsa050161.61163378
26Fatty acid elongation_Homo sapiens_hsa000621.57972856
27Non-homologous end-joining_Homo sapiens_hsa034501.57561414
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.54882968
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54598338
30Tryptophan metabolism_Homo sapiens_hsa003801.50112225
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41598025
32Regulation of autophagy_Homo sapiens_hsa041401.41503332
33Mismatch repair_Homo sapiens_hsa034301.40889580
34Glutathione metabolism_Homo sapiens_hsa004801.37001163
35Pyrimidine metabolism_Homo sapiens_hsa002401.32111874
36DNA replication_Homo sapiens_hsa030301.31698097
37RNA transport_Homo sapiens_hsa030131.30906578
38Lysosome_Homo sapiens_hsa041421.27426841
39Pyruvate metabolism_Homo sapiens_hsa006201.25550721
40Peroxisome_Homo sapiens_hsa041461.23196417
41Base excision repair_Homo sapiens_hsa034101.20597398
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.20179084
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19548236
44Other glycan degradation_Homo sapiens_hsa005111.18559050
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17416191
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15881833
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14236295
48RNA degradation_Homo sapiens_hsa030181.05013373
49Lysine degradation_Homo sapiens_hsa003101.03707977
50Alzheimers disease_Homo sapiens_hsa050101.03389199
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02441379
52Collecting duct acid secretion_Homo sapiens_hsa049661.01128089
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95409659
54Ribosome_Homo sapiens_hsa030100.93591695
55Metabolic pathways_Homo sapiens_hsa011000.91051103
56Circadian rhythm_Homo sapiens_hsa047100.89312783
57Sphingolipid metabolism_Homo sapiens_hsa006000.86214897
58Fatty acid degradation_Homo sapiens_hsa000710.83124201
59Caffeine metabolism_Homo sapiens_hsa002320.82369883
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81187124
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79316677
62Fatty acid metabolism_Homo sapiens_hsa012120.78546219
63Purine metabolism_Homo sapiens_hsa002300.76122860
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74017902
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73291321
66Fatty acid biosynthesis_Homo sapiens_hsa000610.72689325
67Phototransduction_Homo sapiens_hsa047440.72434106
68Glycerolipid metabolism_Homo sapiens_hsa005610.72217333
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68741694
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.67166681
71One carbon pool by folate_Homo sapiens_hsa006700.66714077
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63604465
73Spliceosome_Homo sapiens_hsa030400.61035801
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60075156
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59476614
76Cell cycle_Homo sapiens_hsa041100.59003001
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55287616
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53103132
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51488379
80p53 signaling pathway_Homo sapiens_hsa041150.50834345
81Vitamin B6 metabolism_Homo sapiens_hsa007500.50787275
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50761760
83N-Glycan biosynthesis_Homo sapiens_hsa005100.50418241
84Arginine and proline metabolism_Homo sapiens_hsa003300.49526713
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46594910
86Folate biosynthesis_Homo sapiens_hsa007900.42008480
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39629520
88mRNA surveillance pathway_Homo sapiens_hsa030150.38335085
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.38068023
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37726291
91Rheumatoid arthritis_Homo sapiens_hsa053230.36312463
92Oocyte meiosis_Homo sapiens_hsa041140.36243490
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33971727
94Chemical carcinogenesis_Homo sapiens_hsa052040.32575055
95Synaptic vesicle cycle_Homo sapiens_hsa047210.31585462
96ABC transporters_Homo sapiens_hsa020100.31320738
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30463512
98Vibrio cholerae infection_Homo sapiens_hsa051100.30311899
99Legionellosis_Homo sapiens_hsa051340.26078998
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25699712

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