TIMELESS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.02597842
2DNA replication initiation (GO:0006270)4.97075941
3DNA unwinding involved in DNA replication (GO:0006268)4.89448494
4telomere maintenance via semi-conservative replication (GO:0032201)4.80968817
5DNA strand elongation (GO:0022616)4.79081385
6protein localization to kinetochore (GO:0034501)4.53186011
7DNA replication checkpoint (GO:0000076)4.48431697
8heterochromatin organization (GO:0070828)4.48418216
9telomere maintenance via recombination (GO:0000722)4.41379230
10mitotic recombination (GO:0006312)4.27752463
11DNA replication-dependent nucleosome assembly (GO:0006335)4.13150991
12DNA replication-dependent nucleosome organization (GO:0034723)4.13150991
13DNA ligation (GO:0006266)4.09922011
14nuclear pore complex assembly (GO:0051292)4.04109839
15kinetochore organization (GO:0051383)4.00779085
16nuclear pore organization (GO:0006999)4.00168630
17regulation of nuclear cell cycle DNA replication (GO:0033262)3.93155843
18mitotic metaphase plate congression (GO:0007080)3.91869150
19chromatin remodeling at centromere (GO:0031055)3.91583654
20CENP-A containing nucleosome assembly (GO:0034080)3.91353796
21telomere maintenance via telomere lengthening (GO:0010833)3.89342280
22nucleotide-excision repair, DNA gap filling (GO:0006297)3.85397323
23protein localization to chromosome, centromeric region (GO:0071459)3.81168846
24regulation of translational fidelity (GO:0006450)3.79418870
25chromosome condensation (GO:0030261)3.77741296
26maturation of SSU-rRNA (GO:0030490)3.75690614
27mitotic nuclear envelope disassembly (GO:0007077)3.71444556
28mitotic sister chromatid segregation (GO:0000070)3.71113913
29regulation of centriole replication (GO:0046599)3.70620215
30ribosomal small subunit assembly (GO:0000028)3.67531203
31L-serine metabolic process (GO:0006563)3.67128022
32DNA replication-independent nucleosome assembly (GO:0006336)3.67037744
33DNA replication-independent nucleosome organization (GO:0034724)3.67037744
34kinetochore assembly (GO:0051382)3.64764185
35IMP biosynthetic process (GO:0006188)3.60920189
36negative regulation of mRNA processing (GO:0050686)3.60596776
37non-recombinational repair (GO:0000726)3.59160489
38double-strand break repair via nonhomologous end joining (GO:0006303)3.59160489
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.53580996
40nucleobase biosynthetic process (GO:0046112)3.51261484
41folic acid-containing compound biosynthetic process (GO:0009396)3.47620353
42metaphase plate congression (GO:0051310)3.47563659
43establishment of viral latency (GO:0019043)3.47007082
44pre-miRNA processing (GO:0031054)3.43667055
45sister chromatid segregation (GO:0000819)3.42875219
46DNA duplex unwinding (GO:0032508)3.40852038
47DNA geometric change (GO:0032392)3.40762073
48maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.40042458
49nuclear envelope disassembly (GO:0051081)3.38038110
50membrane disassembly (GO:0030397)3.38038110
51somatic hypermutation of immunoglobulin genes (GO:0016446)3.37224052
52somatic diversification of immune receptors via somatic mutation (GO:0002566)3.37224052
53meiotic chromosome segregation (GO:0045132)3.34929249
54protein K6-linked ubiquitination (GO:0085020)3.34849395
55negative regulation of mRNA metabolic process (GO:1903312)3.34586937
56regulation of centrosome cycle (GO:0046605)3.34280136
57mismatch repair (GO:0006298)3.34007783
58ribosomal large subunit biogenesis (GO:0042273)3.33904878
59regulation of sister chromatid cohesion (GO:0007063)3.32384126
60DNA packaging (GO:0006323)3.31917401
61ribosomal small subunit biogenesis (GO:0042274)3.30351909
62viral transcription (GO:0019083)3.29549444
63negative regulation of RNA splicing (GO:0033119)3.28818993
64mitotic sister chromatid cohesion (GO:0007064)3.27972057
65regulation of double-strand break repair via homologous recombination (GO:0010569)3.27020404
66pore complex assembly (GO:0046931)3.26556437
67mitotic chromosome condensation (GO:0007076)3.26222925
68regulation of helicase activity (GO:0051095)3.25238442
69DNA strand renaturation (GO:0000733)3.25210220
70translational termination (GO:0006415)3.24861887
71histone exchange (GO:0043486)3.22015872
72ribonucleoprotein complex biogenesis (GO:0022613)3.20833288
73establishment of chromosome localization (GO:0051303)3.20493543
74formation of translation preinitiation complex (GO:0001731)3.18523650
75telomere maintenance (GO:0000723)3.16945525
76ribosome biogenesis (GO:0042254)3.16210540
77nucleosome disassembly (GO:0006337)3.15622590
78protein-DNA complex disassembly (GO:0032986)3.15622590
79telomere organization (GO:0032200)3.15303344
80protein complex localization (GO:0031503)3.14787071
81chromatin assembly or disassembly (GO:0006333)3.12210900
82attachment of spindle microtubules to kinetochore (GO:0008608)3.12121229
83spliceosomal snRNP assembly (GO:0000387)3.11577678
84V(D)J recombination (GO:0033151)3.07268375
85negative regulation of DNA-dependent DNA replication (GO:2000104)3.07216668
86positive regulation of chromosome segregation (GO:0051984)3.06866801
87IMP metabolic process (GO:0046040)3.05964109
88chromatin assembly (GO:0031497)3.03729047
89regulation of centrosome duplication (GO:0010824)3.03163331
90purine nucleobase biosynthetic process (GO:0009113)3.02431384
91rRNA processing (GO:0006364)3.00752698
92negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.00329915
93transcription-coupled nucleotide-excision repair (GO:0006283)2.99143500
94DNA replication (GO:0006260)2.98465347
95viral mRNA export from host cell nucleus (GO:0046784)2.98366397
96replication fork processing (GO:0031297)2.96112862
97regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.95355739
98spliceosomal tri-snRNP complex assembly (GO:0000244)2.93219944
99regulation of spindle organization (GO:0090224)2.92307183
100rRNA metabolic process (GO:0016072)2.91377370
101spindle checkpoint (GO:0031577)2.89489941
102negative regulation of histone methylation (GO:0031061)2.89366835
103translational initiation (GO:0006413)2.88689115
104regulation of histone H3-K9 methylation (GO:0051570)2.88658003
105nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.88523319
106mitotic cell cycle (GO:0000278)2.88340609
107translational elongation (GO:0006414)2.87997701
108negative regulation of chromosome segregation (GO:0051985)2.87285556
109DNA topological change (GO:0006265)2.86689545
110DNA conformation change (GO:0071103)2.86552125
111ATP-dependent chromatin remodeling (GO:0043044)2.86413707
112base-excision repair (GO:0006284)2.85515265
113serine family amino acid biosynthetic process (GO:0009070)2.85442308
114establishment of integrated proviral latency (GO:0075713)2.85032301
115DNA synthesis involved in DNA repair (GO:0000731)2.84806305
116nuclear envelope organization (GO:0006998)2.84766428
117intra-S DNA damage checkpoint (GO:0031573)2.84731211
118spindle assembly checkpoint (GO:0071173)2.84581545
119chromosome segregation (GO:0007059)2.83099213
120protein localization to chromosome (GO:0034502)2.82284955
121regulation of chromosome segregation (GO:0051983)2.82170968
122regulation of mitotic metaphase/anaphase transition (GO:0030071)2.81979536
123negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.81742202
124negative regulation of sister chromatid segregation (GO:0033046)2.81742202
125negative regulation of mitotic sister chromatid separation (GO:2000816)2.81742202
126negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81742202
127negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81625375
128positive regulation of mitotic sister chromatid separation (GO:1901970)2.81536805
129positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.81536805
130RNA splicing, via transesterification reactions (GO:0000375)2.80993669
131DNA deamination (GO:0045006)2.80945212
132mRNA splicing, via spliceosome (GO:0000398)2.79341069

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.61973288
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.23275346
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.05944758
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.53234516
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00744493
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99405432
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.90209133
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73142231
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.62153687
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57615070
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.33388797
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.32269092
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.22177816
14* E2F1_21310950_ChIP-Seq_MCF-7_Human2.21994752
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21201453
16* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20648268
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20376725
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18772190
19MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.16800274
20XRN2_22483619_ChIP-Seq_HELA_Human2.13037229
21AR_21909140_ChIP-Seq_LNCAP_Human2.05429370
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05011636
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.00904405
24E2F7_22180533_ChIP-Seq_HELA_Human11.0210274
25VDR_23849224_ChIP-Seq_CD4+_Human1.95342837
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.94700932
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89998582
28FOXP3_21729870_ChIP-Seq_TREG_Human1.88932268
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88751098
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.87749974
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81466035
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77791513
33TTF2_22483619_ChIP-Seq_HELA_Human1.75549763
34DCP1A_22483619_ChIP-Seq_HELA_Human1.74650302
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73583408
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71945723
37* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65527323
38* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61456648
39SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.60807105
40ELK1_19687146_ChIP-ChIP_HELA_Human1.57968284
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56885340
42GABP_19822575_ChIP-Seq_HepG2_Human1.54147583
43CIITA_25753668_ChIP-Seq_RAJI_Human1.53239598
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52604873
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51456097
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50031742
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48660461
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.47518968
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.44258755
50MYC_22102868_ChIP-Seq_BL_Human1.42589918
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41051303
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40956547
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40803913
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40370946
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.39869094
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38741606
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38299782
58KDM5A_27292631_Chip-Seq_BREAST_Human1.35519280
59CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.33202752
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29412198
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29412198
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29412198
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27388592
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.26429605
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25350512
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24154860
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24084687
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23010962
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22293976
70E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20654251
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18317140
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.17526049
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17400292
74* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13485361
75CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13435970
76* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11190080
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10818756
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.07490001
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06754030
80MYC_18940864_ChIP-ChIP_HL60_Human1.04628130
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04536058
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03448040
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02383411
84* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99663140
85VDR_21846776_ChIP-Seq_THP-1_Human0.99351115
86TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98708983
87KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98302888
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95285190
89SOX2_16153702_ChIP-ChIP_HESCs_Human0.94745621
90NANOG_16153702_ChIP-ChIP_HESCs_Human0.92351918
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90945835
92ZNF263_19887448_ChIP-Seq_K562_Human0.90873754
93* SALL1_21062744_ChIP-ChIP_HESCs_Human0.90250246
94* TFEB_21752829_ChIP-Seq_HELA_Human0.90180960
95* CHD1_26751641_Chip-Seq_LNCaP_Human0.89827329
96SPI1_23547873_ChIP-Seq_NB4_Human0.89006781
97NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88542787
98* SOX17_20123909_ChIP-Seq_XEN_Mouse0.87987731
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87952151
100NANOG_21062744_ChIP-ChIP_HESCs_Human0.87751338
101SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87192494
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86689703
103NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.86479054
104TCF3_18692474_ChIP-Seq_MESCs_Mouse0.84253249
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82379850
106ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.81765856
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79935463
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.76463445
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.75586871
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74092076
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72749111
112TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.72131759
113SOX2_18692474_ChIP-Seq_MEFs_Mouse0.71709431
114IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.71240809
115RBPJ_22232070_ChIP-Seq_NCS_Mouse0.71115633
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.68702645
117PKCTHETA_26484144_Chip-Seq_BREAST_Human0.68589048
118TBX5_21415370_ChIP-Seq_HL-1_Mouse0.68080694

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.69704668
2MP0008057_abnormal_DNA_replication4.55844965
3MP0003693_abnormal_embryo_hatching4.45832367
4MP0003111_abnormal_nucleus_morphology4.42247022
5MP0003077_abnormal_cell_cycle3.75050556
6MP0004957_abnormal_blastocyst_morpholog3.70854202
7MP0008058_abnormal_DNA_repair3.48015910
8MP0008007_abnormal_cellular_replicative2.76636692
9MP0008932_abnormal_embryonic_tissue2.67095282
10MP0002396_abnormal_hematopoietic_system2.46027305
11MP0000350_abnormal_cell_proliferation2.05392474
12MP0003786_premature_aging2.03547024
13MP0008877_abnormal_DNA_methylation2.02808040
14MP0010352_gastrointestinal_tract_polyps2.00852647
15MP0001730_embryonic_growth_arrest1.91351386
16MP0006292_abnormal_olfactory_placode1.87331924
17MP0009697_abnormal_copulation1.75797031
18MP0010307_abnormal_tumor_latency1.74231335
19MP0010030_abnormal_orbit_morphology1.72626716
20MP0000490_abnormal_crypts_of1.70598364
21MP0003890_abnormal_embryonic-extraembry1.70483005
22MP0001672_abnormal_embryogenesis/_devel1.64929375
23MP0005380_embryogenesis_phenotype1.64929375
24MP0003705_abnormal_hypodermis_morpholog1.62236265
25MP0001346_abnormal_lacrimal_gland1.60835421
26MP0003941_abnormal_skin_development1.56810715
27MP0002085_abnormal_embryonic_tissue1.52232962
28MP0003121_genomic_imprinting1.51681451
29MP0003123_paternal_imprinting1.51028266
30MP0001697_abnormal_embryo_size1.49899884
31MP0003984_embryonic_growth_retardation1.42145622
32MP0002084_abnormal_developmental_patter1.41245377
33MP0002088_abnormal_embryonic_growth/wei1.39016744
34MP0009379_abnormal_foot_pigmentation1.37507141
35MP0003718_maternal_effect1.35303164
36MP0004808_abnormal_hematopoietic_stem1.34357977
37MP0000313_abnormal_cell_death1.33899390
38MP0002019_abnormal_tumor_incidence1.33664018
39* MP0002080_prenatal_lethality1.33333636
40MP0002086_abnormal_extraembryonic_tissu1.31514532
41MP0004133_heterotaxia1.27545289
42MP0003763_abnormal_thymus_physiology1.27182846
43MP0004233_abnormal_muscle_weight1.26847173
44MP0004197_abnormal_fetal_growth/weight/1.24840329
45MP0001293_anophthalmia1.22253169
46MP0005076_abnormal_cell_differentiation1.19521028
47MP0002210_abnormal_sex_determination1.17537992
48MP0000703_abnormal_thymus_morphology1.17064236
49MP0004185_abnormal_adipocyte_glucose1.14927261
50MP0001545_abnormal_hematopoietic_system1.13765767
51MP0005397_hematopoietic_system_phenotyp1.13765767
52MP0009333_abnormal_splenocyte_physiolog1.13203036
53MP0003136_yellow_coat_color1.12138731
54MP0003861_abnormal_nervous_system1.06615037
55MP0003937_abnormal_limbs/digits/tail_de1.05803534
56MP0003942_abnormal_urinary_system1.05454260
57MP0002009_preneoplasia1.05429865
58MP0002398_abnormal_bone_marrow1.02978612
59MP0002233_abnormal_nose_morphology1.01924975
60MP0003567_abnormal_fetal_cardiomyocyte0.99377843
61MP0001849_ear_inflammation0.96760005
62MP0009278_abnormal_bone_marrow0.96445039
63MP0002132_abnormal_respiratory_system0.96309135
64MP0001145_abnormal_male_reproductive0.96214189
65MP0006035_abnormal_mitochondrial_morpho0.94171273
66MP0003787_abnormal_imprinting0.94013898
67MP0002722_abnormal_immune_system0.93572931
68MP0002111_abnormal_tail_morphology0.93315538
69MP0000566_synostosis0.90649626
70MP0000689_abnormal_spleen_morphology0.90103010
71MP0000358_abnormal_cell_content/0.90004649
72MP0003119_abnormal_digestive_system0.90001589
73MP0003943_abnormal_hepatobiliary_system0.89361986
74MP0003115_abnormal_respiratory_system0.89257573
75MP0000049_abnormal_middle_ear0.88515314
76MP0002160_abnormal_reproductive_system0.87366898
77MP0001119_abnormal_female_reproductive0.87072347
78MP0009053_abnormal_anal_canal0.85368195
79MP0004147_increased_porphyrin_level0.85224303
80MP0005499_abnormal_olfactory_system0.84554500
81MP0005394_taste/olfaction_phenotype0.84554500
82MP0003315_abnormal_perineum_morphology0.83958026
83MP0002095_abnormal_skin_pigmentation0.83207417
84MP0000653_abnormal_sex_gland0.83106664
85MP0001286_abnormal_eye_development0.82863154
86MP0002938_white_spotting0.82640927
87MP0005075_abnormal_melanosome_morpholog0.82390696
88MP0000537_abnormal_urethra_morphology0.80026659
89MP0001986_abnormal_taste_sensitivity0.78879945
90MP0001929_abnormal_gametogenesis0.77873904
91MP0005174_abnormal_tail_pigmentation0.77270876
92MP0008789_abnormal_olfactory_epithelium0.77197313
93MP0004264_abnormal_extraembryonic_tissu0.77130085
94MP0000858_altered_metastatic_potential0.77117022
95MP0003385_abnormal_body_wall0.75949195
96MP0005501_abnormal_skin_physiology0.75660115
97MP0000432_abnormal_head_morphology0.75083992
98MP0002429_abnormal_blood_cell0.74945996
99MP0005389_reproductive_system_phenotype0.74897867
100MP0001915_intracranial_hemorrhage0.73943565
101MP0002163_abnormal_gland_morphology0.73697015
102MP0009703_decreased_birth_body0.73234060
103MP0002075_abnormal_coat/hair_pigmentati0.72102461
104MP0000579_abnormal_nail_morphology0.70429545
105MP0003755_abnormal_palate_morphology0.67836310
106MP0002116_abnormal_craniofacial_bone0.66879465
107MP0002081_perinatal_lethality0.66774795
108MP0009672_abnormal_birth_weight0.66649574
109MP0000716_abnormal_immune_system0.66642439
110MP0002092_abnormal_eye_morphology0.66595424
111MP0001661_extended_life_span0.66397968
112MP0005384_cellular_phenotype0.66309761
113MP0003935_abnormal_craniofacial_develop0.65784664
114MP0000428_abnormal_craniofacial_morphol0.65647213
115MP0001919_abnormal_reproductive_system0.65447330
116MP0002877_abnormal_melanocyte_morpholog0.65408387
117MP0002089_abnormal_postnatal_growth/wei0.64872099
118MP0001186_pigmentation_phenotype0.63925501
119MP0002697_abnormal_eye_size0.62950690
120MP0002102_abnormal_ear_morphology0.62921346
121MP0000015_abnormal_ear_pigmentation0.62866756
122MP0005621_abnormal_cell_physiology0.62479061
123MP0002249_abnormal_larynx_morphology0.61738940
124MP0000631_abnormal_neuroendocrine_gland0.61726269
125MP0003448_altered_tumor_morphology0.60697624
126MP0003699_abnormal_female_reproductive0.59288474
127MP0001800_abnormal_humoral_immune0.59146425
128MP0002114_abnormal_axial_skeleton0.58664351
129MP0001529_abnormal_vocalization0.58380425
130MP0003938_abnormal_ear_development0.58201375
131MP0008995_early_reproductive_senescence0.58072705

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.62661876
2Chromsome breakage (HP:0040012)5.55834941
3Birth length less than 3rd percentile (HP:0003561)4.23074395
4Reticulocytopenia (HP:0001896)4.15766053
5Duplicated collecting system (HP:0000081)4.02213440
6Meckel diverticulum (HP:0002245)3.68348851
7Abnormality of chromosome stability (HP:0003220)3.64225228
8Medulloblastoma (HP:0002885)3.63017068
9Abnormality of the renal collecting system (HP:0004742)3.61327504
10Abnormality of the preputium (HP:0100587)3.58416205
11Abnormality of the ileum (HP:0001549)3.58019437
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.55825669
13Abnormality of cochlea (HP:0000375)3.36748458
14Breast hypoplasia (HP:0003187)3.28872035
15Patellar aplasia (HP:0006443)3.14496293
16Colon cancer (HP:0003003)3.02150459
17Aplasia/Hypoplasia of the patella (HP:0006498)2.93772004
18Ectopic kidney (HP:0000086)2.91807037
19Small intestinal stenosis (HP:0012848)2.91609999
20Duodenal stenosis (HP:0100867)2.91609999
21Myelodysplasia (HP:0002863)2.88075112
22Selective tooth agenesis (HP:0001592)2.86977502
23Abnormality of cells of the erythroid lineage (HP:0012130)2.86057885
24Absent thumb (HP:0009777)2.85307805
25Ependymoma (HP:0002888)2.82864963
26Absent radius (HP:0003974)2.82773266
27Clubbing of toes (HP:0100760)2.80920244
28Overlapping toe (HP:0001845)2.75978957
29Aplastic anemia (HP:0001915)2.69681578
30Abnormal number of erythroid precursors (HP:0012131)2.69266838
31Aplasia involving forearm bones (HP:0009822)2.63330342
32Absent forearm bone (HP:0003953)2.63330342
33High anterior hairline (HP:0009890)2.63033504
34Abnormal number of incisors (HP:0011064)2.62732589
35Morphological abnormality of the inner ear (HP:0011390)2.58793185
36Agnosia (HP:0010524)2.58023839
37Supernumerary spleens (HP:0009799)2.54801486
38Abnormality of the labia minora (HP:0012880)2.52737363
39Abnormality of the carotid arteries (HP:0005344)2.51411492
40Volvulus (HP:0002580)2.48543356
41Rhabdomyosarcoma (HP:0002859)2.47900390
42Bone marrow hypocellularity (HP:0005528)2.46295719
43Abnormal lung lobation (HP:0002101)2.44520481
44Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41676415
45Nephroblastoma (Wilms tumor) (HP:0002667)2.41446200
46Triphalangeal thumb (HP:0001199)2.41443899
47Abnormality of the duodenum (HP:0002246)2.39295089
48Short thumb (HP:0009778)2.38310542
49Cortical dysplasia (HP:0002539)2.37184752
50Sloping forehead (HP:0000340)2.34026476
51Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.28533512
52Absent epiphyses (HP:0010577)2.28533512
53Embryonal renal neoplasm (HP:0011794)2.27006934
54Broad distal phalanx of finger (HP:0009836)2.26738886
55Rough bone trabeculation (HP:0100670)2.26294296
56Asplenia (HP:0001746)2.25504274
57Impulsivity (HP:0100710)2.25283490
58Tracheoesophageal fistula (HP:0002575)2.23632269
59Pallor (HP:0000980)2.22949249
60Oral leukoplakia (HP:0002745)2.22697933
61Diastasis recti (HP:0001540)2.20859359
62Abnormality of DNA repair (HP:0003254)2.19583087
63Increased nuchal translucency (HP:0010880)2.19451199
64Horseshoe kidney (HP:0000085)2.16454647
65Microvesicular hepatic steatosis (HP:0001414)2.14984243
66Hyperacusis (HP:0010780)2.13498841
67Premature graying of hair (HP:0002216)2.13410874
68Facial cleft (HP:0002006)2.12107098
6911 pairs of ribs (HP:0000878)2.11151080
70High pitched voice (HP:0001620)2.10472215
71Choanal atresia (HP:0000453)2.10069580
72Atresia of the external auditory canal (HP:0000413)2.08944811
73Ureteral duplication (HP:0000073)2.07617865
74Aplasia/Hypoplasia of the spleen (HP:0010451)2.07427647
75Macrocytic anemia (HP:0001972)2.07217478
76Acute lymphatic leukemia (HP:0006721)2.06091275
77Overriding aorta (HP:0002623)2.05346530
78Abnormality of the calcaneus (HP:0008364)2.03510312
79Neoplasm of the oral cavity (HP:0100649)2.02627634
80Proximal placement of thumb (HP:0009623)2.02428039
81Abnormality of the anterior horn cell (HP:0006802)2.02111931
82Degeneration of anterior horn cells (HP:0002398)2.02111931
83Glioma (HP:0009733)1.99727591
84Multiple enchondromatosis (HP:0005701)1.99338128
85Neoplasm of the pancreas (HP:0002894)1.95688077
86Deviation of the thumb (HP:0009603)1.94499036
87Irregular epiphyses (HP:0010582)1.94256450
88Basal cell carcinoma (HP:0002671)1.93310591
89Supernumerary bones of the axial skeleton (HP:0009144)1.91527628
90Abnormality of abdominal situs (HP:0011620)1.91056501
91Abdominal situs inversus (HP:0003363)1.91056501
92Progressive muscle weakness (HP:0003323)1.89722499
93Rib fusion (HP:0000902)1.88607716
94Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.88490746
95Astrocytoma (HP:0009592)1.85596736
96Abnormality of the astrocytes (HP:0100707)1.85596736
97Amaurosis fugax (HP:0100576)1.85076667
98Aplasia/Hypoplasia of the sternum (HP:0006714)1.84770733
99Neoplasm of striated muscle (HP:0009728)1.84159115
100Duplication of thumb phalanx (HP:0009942)1.84102990
101Abnormality of reticulocytes (HP:0004312)1.82371913
102Carpal bone hypoplasia (HP:0001498)1.81973660
103Broad thumb (HP:0011304)1.81020803
104Facial hemangioma (HP:0000329)1.80752106
105Cafe-au-lait spot (HP:0000957)1.80456297
106Deep philtrum (HP:0002002)1.80308917
107Abnormality of the septum pellucidum (HP:0007375)1.79210881
108Lymphoma (HP:0002665)1.78205566
109Absent septum pellucidum (HP:0001331)1.78180400
110Cleft eyelid (HP:0000625)1.76160864
111Embryonal neoplasm (HP:0002898)1.76076662
112Microglossia (HP:0000171)1.75552223
113Microtia (HP:0008551)1.75424843
114Supernumerary ribs (HP:0005815)1.75300313
115Squamous cell carcinoma (HP:0002860)1.72403898
116Obsessive-compulsive behavior (HP:0000722)1.72134704
117Trigonocephaly (HP:0000243)1.70948248
118Abnormal trabecular bone morphology (HP:0100671)1.70939402
119Septo-optic dysplasia (HP:0100842)1.69538112
120Prominent nose (HP:0000448)1.68838784
121Urethral obstruction (HP:0000796)1.68370867
122Calcaneovalgus deformity (HP:0001848)1.68138501
123Hypoplasia of the capital femoral epiphysis (HP:0003090)1.67682667
124Insomnia (HP:0100785)1.67541227
125Elfin facies (HP:0004428)1.67472518
126Deep palmar crease (HP:0006191)1.66658960
127Aplasia/Hypoplasia of the earlobes (HP:0009906)1.65599152
128Abnormality of pyrimidine metabolism (HP:0004353)1.65588413
129Cellular immunodeficiency (HP:0005374)1.64558858
130Renal duplication (HP:0000075)1.63428617
131Slender long bone (HP:0003100)1.63221287
132Broad phalanges of the hand (HP:0009768)1.62425122
133Abnormality of the fingertips (HP:0001211)1.61732299
134Tetralogy of Fallot (HP:0001636)1.61359561
135Chin dimple (HP:0010751)1.61155120
136Neoplasm of the colon (HP:0100273)1.60748802
137Sandal gap (HP:0001852)1.60656987
138Arteriovenous malformation (HP:0100026)1.60358847
139Missing ribs (HP:0000921)1.60309658
140Optic nerve coloboma (HP:0000588)1.58379717
141Pancytopenia (HP:0001876)1.58349959

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.68955781
2BUB13.84935535
3WEE13.52772116
4TTK2.96780491
5SRPK12.85598253
6VRK22.76055477
7SMG12.69208621
8NEK22.63332480
9CDK122.47619047
10EIF2AK12.39892604
11PLK42.20955668
12MKNK12.20714245
13CDK72.18374545
14ZAK2.15987180
15ATR2.15982710
16PLK12.08735150
17NME22.03840266
18TLK12.03227310
19MKNK21.93125718
20STK161.92992215
21RPS6KB21.91855440
22TAF11.89863755
23TSSK61.88721897
24VRK11.84994791
25CHEK21.78199278
26AURKB1.75565913
27PASK1.66729989
28ICK1.54398677
29EEF2K1.49558648
30BRD41.46856682
31CHEK11.46300789
32EPHA21.43513405
33PNCK1.43456547
34PLK31.43160310
35TRIB31.40184681
36CDK41.39193965
37ACVR1B1.35384914
38STK101.34369720
39STK41.32040737
40DYRK31.27842564
41TESK21.26486461
42EIF2AK31.26003873
43NEK11.22554718
44MAP3K81.22139509
45CLK11.21665733
46AURKA1.21506280
47ATM1.19367091
48LATS11.16347418
49PIM11.15245087
50TGFBR11.13493488
51LATS21.09716890
52BRSK21.08713820
53CDK21.00219719
54PAK40.97366517
55NME10.94955322
56EIF2AK20.93507359
57PIM20.92989106
58YES10.92911072
59MAP4K10.90942696
60CAMK1G0.86615095
61CDK80.86227154
62MAP3K100.84083612
63RPS6KA40.81108407
64IRAK40.80746458
65SCYL20.79391067
66FGFR20.79357041
67FLT30.79339038
68ALK0.78829017
69CDK10.78388904
70CAMK1D0.76503170
71CCNB10.75623384
72CSNK2A10.72350014
73CSNK2A20.71258706
74CDK60.70143320
75PBK0.66318057
76PAK10.61635818
77BRSK10.60789164
78STK30.59184404
79IRAK30.58917089
80MELK0.57997670
81RPS6KA50.57741617
82PRKD30.57183136
83BTK0.56827465
84PRKCI0.53823003
85FGFR10.51893888
86CDK30.50628160
87NUAK10.50158502
88CDK90.47578360
89PRKDC0.45452585
90STK38L0.45096601
91KDR0.44203349
92DYRK20.43707615
93TEC0.43648780
94CDK11A0.43131798
95MST40.42831657
96TXK0.42571153
97CDK150.40726516
98AKT10.40358753
99TAOK20.39763124
100CDK180.39011262
101MTOR0.38959913
102CSNK1D0.38616603
103TYRO30.38524117
104MAP3K90.38378101
105MAPK140.38246403
106FGFR40.38167947
107JAK30.37755844
108RPS6KC10.37685057
109RPS6KL10.37685057
110PKN20.36407319
111AKT30.35659572
112BMX0.35607014
113AKT20.35435402
114IKBKB0.35378264
115BRAF0.34252902
116RPS6KA60.33692439
117CSNK1E0.33362529
118LYN0.33249869
119CSF1R0.33063347
120SIK10.33039817
121CHUK0.31806180
122MAP2K20.31732045
123CDK140.29074285
124ERBB40.28527730
125MAPK10.28499024
126LCK0.27447271
127MST1R0.27407139
128KIT0.27108537
129GRK60.26826113
130GSK3B0.26183925
131MET0.25038848
132DMPK0.23293333

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.25494345
2Mismatch repair_Homo sapiens_hsa034304.50271641
3Base excision repair_Homo sapiens_hsa034103.28387003
4Homologous recombination_Homo sapiens_hsa034403.27919403
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.26027568
6Spliceosome_Homo sapiens_hsa030403.23568760
7Ribosome_Homo sapiens_hsa030103.13424699
8Fanconi anemia pathway_Homo sapiens_hsa034602.99819100
9Nucleotide excision repair_Homo sapiens_hsa034202.90656624
10One carbon pool by folate_Homo sapiens_hsa006702.81857766
11RNA transport_Homo sapiens_hsa030132.81629599
12Cell cycle_Homo sapiens_hsa041102.79482196
13RNA polymerase_Homo sapiens_hsa030202.77071344
14Non-homologous end-joining_Homo sapiens_hsa034502.35631091
15Proteasome_Homo sapiens_hsa030502.27031095
16Pyrimidine metabolism_Homo sapiens_hsa002402.23591118
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13070493
18RNA degradation_Homo sapiens_hsa030181.91632951
19Basal transcription factors_Homo sapiens_hsa030221.86696152
20mRNA surveillance pathway_Homo sapiens_hsa030151.79807964
21p53 signaling pathway_Homo sapiens_hsa041151.56640869
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35715776
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29546191
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.29520064
25Systemic lupus erythematosus_Homo sapiens_hsa053221.27009527
26Herpes simplex infection_Homo sapiens_hsa051681.17062759
27Purine metabolism_Homo sapiens_hsa002301.16542655
28Carbon metabolism_Homo sapiens_hsa012001.14867383
29Epstein-Barr virus infection_Homo sapiens_hsa051691.13311795
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12367334
31Pyruvate metabolism_Homo sapiens_hsa006200.99399486
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98977656
33Viral carcinogenesis_Homo sapiens_hsa052030.98471357
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88035485
35Primary immunodeficiency_Homo sapiens_hsa053400.87701152
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87341198
37HTLV-I infection_Homo sapiens_hsa051660.86474473
38MicroRNAs in cancer_Homo sapiens_hsa052060.84275648
39Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81527696
40Central carbon metabolism in cancer_Homo sapiens_hsa052300.79927884
41N-Glycan biosynthesis_Homo sapiens_hsa005100.79766805
42Antigen processing and presentation_Homo sapiens_hsa046120.79258743
43Steroid biosynthesis_Homo sapiens_hsa001000.77091156
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73625822
45NF-kappa B signaling pathway_Homo sapiens_hsa040640.72738745
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71588624
47Small cell lung cancer_Homo sapiens_hsa052220.68913803
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68796256
49Measles_Homo sapiens_hsa051620.67651380
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67179413
51Basal cell carcinoma_Homo sapiens_hsa052170.66375212
52Notch signaling pathway_Homo sapiens_hsa043300.64684886
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63750507
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61195754
55Oocyte meiosis_Homo sapiens_hsa041140.60022001
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58146351
57Apoptosis_Homo sapiens_hsa042100.57438273
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56588096
59Protein export_Homo sapiens_hsa030600.56331500
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55972069
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51908092
62Folate biosynthesis_Homo sapiens_hsa007900.50446968
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50290550
64TGF-beta signaling pathway_Homo sapiens_hsa043500.49853440
65Fatty acid elongation_Homo sapiens_hsa000620.49801973
66Fructose and mannose metabolism_Homo sapiens_hsa000510.49103255
67Hepatitis B_Homo sapiens_hsa051610.48082291
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.47927804
69Propanoate metabolism_Homo sapiens_hsa006400.46232162
70Hematopoietic cell lineage_Homo sapiens_hsa046400.46184365
71Legionellosis_Homo sapiens_hsa051340.45120102
72Thyroid cancer_Homo sapiens_hsa052160.44486852
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43590781
74Galactose metabolism_Homo sapiens_hsa000520.43555180
75Colorectal cancer_Homo sapiens_hsa052100.43214956
76Chronic myeloid leukemia_Homo sapiens_hsa052200.43208498
77Hippo signaling pathway_Homo sapiens_hsa043900.43013952
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42871404
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41488355
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.41296849
81Pathways in cancer_Homo sapiens_hsa052000.40892486
82Viral myocarditis_Homo sapiens_hsa054160.40719886
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40399840
84Alcoholism_Homo sapiens_hsa050340.40164169
85Non-small cell lung cancer_Homo sapiens_hsa052230.39723314
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.38986674
87Influenza A_Homo sapiens_hsa051640.38940596
88Allograft rejection_Homo sapiens_hsa053300.38808283
89Graft-versus-host disease_Homo sapiens_hsa053320.38468235
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38298375
91Endometrial cancer_Homo sapiens_hsa052130.38244685
92Sulfur relay system_Homo sapiens_hsa041220.36249828
93Lysine degradation_Homo sapiens_hsa003100.33876660
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.33446830
95Prostate cancer_Homo sapiens_hsa052150.33406590
96Pentose phosphate pathway_Homo sapiens_hsa000300.33210621
97Acute myeloid leukemia_Homo sapiens_hsa052210.32710386
98Shigellosis_Homo sapiens_hsa051310.32416984
99Autoimmune thyroid disease_Homo sapiens_hsa053200.32350710
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32308669
101Glutathione metabolism_Homo sapiens_hsa004800.32187166
102Hedgehog signaling pathway_Homo sapiens_hsa043400.31862811
103Arginine and proline metabolism_Homo sapiens_hsa003300.30335944
104Metabolic pathways_Homo sapiens_hsa011000.29793361
105Biosynthesis of amino acids_Homo sapiens_hsa012300.29629575
106Fatty acid metabolism_Homo sapiens_hsa012120.29355645
107Vitamin B6 metabolism_Homo sapiens_hsa007500.29108155
108Arginine biosynthesis_Homo sapiens_hsa002200.28633137
109Selenocompound metabolism_Homo sapiens_hsa004500.28503917
110Wnt signaling pathway_Homo sapiens_hsa043100.27722488
111Huntingtons disease_Homo sapiens_hsa050160.26295193
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26193745
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25961458
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.25902204
115Adherens junction_Homo sapiens_hsa045200.25858359
116Arachidonic acid metabolism_Homo sapiens_hsa005900.25459100
117Bladder cancer_Homo sapiens_hsa052190.24932195
118Leishmaniasis_Homo sapiens_hsa051400.24464722
119Melanoma_Homo sapiens_hsa052180.23690458
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22783610
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.22075654
122Tight junction_Homo sapiens_hsa045300.21951843
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21079798
124Asthma_Homo sapiens_hsa053100.20852844
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20221886
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19426781
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19355962
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18641535
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18282924
130Glioma_Homo sapiens_hsa052140.17852379
131HIF-1 signaling pathway_Homo sapiens_hsa040660.17488226
132Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16797276
133B cell receptor signaling pathway_Homo sapiens_hsa046620.15959695
134T cell receptor signaling pathway_Homo sapiens_hsa046600.15317734
135Pancreatic cancer_Homo sapiens_hsa052120.14473068
136Melanogenesis_Homo sapiens_hsa049160.12617919

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