Rank | Gene Set | Z-score |
---|---|---|
1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 6.18995860 |
2 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.71388285 |
3 | ATP synthesis coupled proton transport (GO:0015986) | 5.71388285 |
4 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.68120255 |
5 | protein neddylation (GO:0045116) | 5.51067409 |
6 | proteasome assembly (GO:0043248) | 5.49400982 |
7 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.23687272 |
8 | respiratory electron transport chain (GO:0022904) | 4.89530558 |
9 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.77779295 |
10 | termination of RNA polymerase III transcription (GO:0006386) | 4.77779295 |
11 | electron transport chain (GO:0022900) | 4.77197535 |
12 | chaperone-mediated protein transport (GO:0072321) | 4.76804724 |
13 | 7-methylguanosine mRNA capping (GO:0006370) | 4.60085894 |
14 | 7-methylguanosine RNA capping (GO:0009452) | 4.48693927 |
15 | RNA capping (GO:0036260) | 4.48693927 |
16 | CENP-A containing nucleosome assembly (GO:0034080) | 4.46775984 |
17 | chromatin remodeling at centromere (GO:0031055) | 4.33118350 |
18 | regulation of mitochondrial translation (GO:0070129) | 4.31762961 |
19 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.29623356 |
20 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.14594601 |
21 | cullin deneddylation (GO:0010388) | 4.13880892 |
22 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 4.13762622 |
23 | purine nucleobase biosynthetic process (GO:0009113) | 4.05018274 |
24 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.00710477 |
25 | rRNA modification (GO:0000154) | 4.00303248 |
26 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.99484549 |
27 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.99276004 |
28 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.98743321 |
29 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.95448891 |
30 | negative regulation of ligase activity (GO:0051352) | 3.95448891 |
31 | ribosome assembly (GO:0042255) | 3.90680919 |
32 | protein complex biogenesis (GO:0070271) | 3.86111670 |
33 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.81030712 |
34 | NADH dehydrogenase complex assembly (GO:0010257) | 3.81030712 |
35 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.81030712 |
36 | establishment of integrated proviral latency (GO:0075713) | 3.78737458 |
37 | termination of RNA polymerase I transcription (GO:0006363) | 3.78469869 |
38 | DNA replication checkpoint (GO:0000076) | 3.77454245 |
39 | protein deneddylation (GO:0000338) | 3.77148941 |
40 | amino acid salvage (GO:0043102) | 3.75406479 |
41 | L-methionine salvage (GO:0071267) | 3.75406479 |
42 | L-methionine biosynthetic process (GO:0071265) | 3.75406479 |
43 | histone exchange (GO:0043486) | 3.69884760 |
44 | transcription from RNA polymerase I promoter (GO:0006360) | 3.69801491 |
45 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.65171722 |
46 | * protein targeting to mitochondrion (GO:0006626) | 3.62282344 |
47 | * establishment of protein localization to mitochondrion (GO:0072655) | 3.60525511 |
48 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.52124202 |
49 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.50236484 |
50 | positive regulation of ligase activity (GO:0051351) | 3.48448995 |
51 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.47421583 |
52 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.47421583 |
53 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.47421583 |
54 | positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968) | 3.45711550 |
55 | nucleobase biosynthetic process (GO:0046112) | 3.45660751 |
56 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.44322267 |
57 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.44322267 |
58 | * protein localization to mitochondrion (GO:0070585) | 3.43565488 |
59 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.43422745 |
60 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.40939633 |
61 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.40939633 |
62 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.38866494 |
63 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 3.38758495 |
64 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.35978648 |
65 | metaphase plate congression (GO:0051310) | 3.31894315 |
66 | DNA double-strand break processing (GO:0000729) | 3.31675868 |
67 | ribosome biogenesis (GO:0042254) | 3.30297085 |
68 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.27350577 |
69 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.26946817 |
70 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.26946817 |
71 | blastocyst development (GO:0001824) | 3.25365440 |
72 | positive regulation of mitochondrial fission (GO:0090141) | 3.24554171 |
73 | mitochondrial RNA metabolic process (GO:0000959) | 3.23617292 |
74 | IMP biosynthetic process (GO:0006188) | 3.23460817 |
75 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.23180535 |
76 | GTP biosynthetic process (GO:0006183) | 3.23149709 |
77 | cell cycle G1/S phase transition (GO:0044843) | 3.20740164 |
78 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.20740164 |
79 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.20490410 |
80 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.20223860 |
81 | DNA replication-independent nucleosome organization (GO:0034724) | 3.18969746 |
82 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.18969746 |
83 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.18944786 |
84 | ribosomal large subunit biogenesis (GO:0042273) | 3.16931587 |
85 | transcription elongation from RNA polymerase II promoter (GO:0006368) | 3.16266403 |
86 | transcription from mitochondrial promoter (GO:0006390) | 3.15637791 |
87 | DNA strand elongation (GO:0022616) | 3.13827067 |
88 | kinetochore assembly (GO:0051382) | 3.13236432 |
89 | cellular component biogenesis (GO:0044085) | 3.12684080 |
90 | peptidyl-histidine modification (GO:0018202) | 3.12595460 |
91 | cytochrome complex assembly (GO:0017004) | 3.11461808 |
92 | establishment of viral latency (GO:0019043) | 3.11230870 |
93 | protein-cofactor linkage (GO:0018065) | 3.11019518 |
94 | mitotic metaphase plate congression (GO:0007080) | 3.09137785 |
95 | translation (GO:0006412) | 3.08891614 |
96 | regulation of cellular amine metabolic process (GO:0033238) | 3.08477526 |
97 | regulation of ligase activity (GO:0051340) | 3.08399477 |
98 | kinetochore organization (GO:0051383) | 3.07163611 |
99 | DNA-templated transcription, elongation (GO:0006354) | 3.07087869 |
100 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.04169674 |
101 | rRNA methylation (GO:0031167) | 3.03102209 |
102 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.01767352 |
103 | formation of translation preinitiation complex (GO:0001731) | 3.00790651 |
104 | long-chain fatty acid biosynthetic process (GO:0042759) | 2.99302316 |
105 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.99147207 |
106 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.97836534 |
107 | maturation of 5.8S rRNA (GO:0000460) | 2.97480559 |
108 | negative regulation of protein ubiquitination (GO:0031397) | 2.97007778 |
109 | hydrogen ion transmembrane transport (GO:1902600) | 2.95316623 |
110 | telomere maintenance via recombination (GO:0000722) | 2.95116750 |
111 | amino acid activation (GO:0043038) | 2.94393590 |
112 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.93756887 |
113 | rRNA processing (GO:0006364) | 2.93222316 |
114 | spliceosomal snRNP assembly (GO:0000387) | 2.91259795 |
115 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.87291521 |
116 | rRNA metabolic process (GO:0016072) | 2.86287082 |
117 | ATP biosynthetic process (GO:0006754) | 2.85358937 |
118 | positive regulation of viral transcription (GO:0050434) | 2.82395813 |
119 | response to redox state (GO:0051775) | 2.81964057 |
120 | UTP biosynthetic process (GO:0006228) | 2.78123110 |
121 | oxidative phosphorylation (GO:0006119) | 2.77471295 |
122 | pseudouridine synthesis (GO:0001522) | 2.75153512 |
123 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.74497655 |
124 | * mitochondrial transport (GO:0006839) | 2.74181081 |
125 | DNA deamination (GO:0045006) | 2.73752345 |
126 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.73694431 |
127 | respiratory chain complex IV assembly (GO:0008535) | 2.72964197 |
128 | NADH metabolic process (GO:0006734) | 2.72404476 |
129 | GMP metabolic process (GO:0046037) | 2.70788507 |
130 | quinone biosynthetic process (GO:1901663) | 2.67743937 |
131 | ubiquinone biosynthetic process (GO:0006744) | 2.67743937 |
132 | positive regulation of cell cycle arrest (GO:0071158) | 2.67542968 |
133 | DNA damage response, detection of DNA damage (GO:0042769) | 2.65199372 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 5.45224711 |
2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.13772247 |
3 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.69574970 |
4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.24976393 |
5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.14332598 |
6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.99436520 |
7 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.82283411 |
8 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.77443873 |
9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.74503701 |
10 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.29686018 |
11 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.17457134 |
12 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.08803642 |
13 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.01402219 |
14 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.00323486 |
15 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.47870604 |
16 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.43726065 |
17 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.34904166 |
18 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.26026279 |
19 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.25461416 |
20 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.20944610 |
21 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.18713792 |
22 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.17114581 |
23 | * PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.09626509 |
24 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.97555697 |
25 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.95654732 |
26 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.89788857 |
27 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.88495458 |
28 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.85782759 |
29 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.73993661 |
30 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.72714833 |
31 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.72710067 |
32 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.69474476 |
33 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.69304346 |
34 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.66784376 |
35 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.66595925 |
36 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.65619302 |
37 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.64781370 |
38 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.63969742 |
39 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.62147357 |
40 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.59180428 |
41 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.56622202 |
42 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.56018429 |
43 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.43718703 |
44 | VDR_22108803_ChIP-Seq_LS180_Human | 1.41401148 |
45 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.39808246 |
46 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.38760906 |
47 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.38480519 |
48 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.37158533 |
49 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.35646644 |
50 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.35456134 |
51 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.32892829 |
52 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.31636108 |
53 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.31083193 |
54 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.30725543 |
55 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.28378216 |
56 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.27752070 |
57 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.27529459 |
58 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.27349009 |
59 | * HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.26578523 |
60 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.25067689 |
61 | * ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.22237864 |
62 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.18700314 |
63 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.15268040 |
64 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.14773448 |
65 | FUS_26573619_Chip-Seq_HEK293_Human | 1.14754394 |
66 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.14485510 |
67 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.09869466 |
68 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.09740853 |
69 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.06818845 |
70 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.04351964 |
71 | * BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.98531584 |
72 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 0.97667938 |
73 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.97361612 |
74 | * TAF15_26573619_Chip-Seq_HEK293_Human | 0.96135636 |
75 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.95046935 |
76 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.94991765 |
77 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.94973811 |
78 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.94605744 |
79 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.94304547 |
80 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.93249857 |
81 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.92772602 |
82 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.92364034 |
83 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.90869862 |
84 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.90134825 |
85 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 0.89974606 |
86 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.89293531 |
87 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.89063513 |
88 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.89033658 |
89 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.86081586 |
90 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.83759783 |
91 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.83187848 |
92 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.82703685 |
93 | EWS_26573619_Chip-Seq_HEK293_Human | 0.82493557 |
94 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.82209879 |
95 | GBX2_23144817_ChIP-Seq_PC3_Human | 0.81483487 |
96 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.77395805 |
97 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.76520258 |
98 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.76184070 |
99 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.75461232 |
100 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.75417860 |
101 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.75043938 |
102 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 0.74864940 |
103 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.74819720 |
104 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.74255937 |
105 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.73592871 |
106 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.72883144 |
107 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.70182612 |
108 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.69541542 |
109 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.69504308 |
110 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.69024880 |
111 | EOMES_21245162_ChIP-Seq_HESCs_Human | 0.68748776 |
112 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.68123474 |
113 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.67878522 |
114 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.67552432 |
115 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.66780993 |
116 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.66252947 |
117 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.66041250 |
118 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.65190208 |
119 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.65031453 |
120 | * NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.64599362 |
121 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.64471284 |
122 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.64406415 |
123 | JUN_21703547_ChIP-Seq_K562_Human | 0.64138287 |
124 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.63657023 |
125 | TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse | 0.62948444 |
126 | REST_19997604_ChIP-ChIP_NEURONS_Mouse | 0.62515301 |
127 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.61693783 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003806_abnormal_nucleotide_metabolis | 4.98762167 |
2 | MP0003880_abnormal_central_pattern | 3.61197799 |
3 | MP0003718_maternal_effect | 3.22292277 |
4 | MP0001529_abnormal_vocalization | 3.03888278 |
5 | MP0003693_abnormal_embryo_hatching | 2.66194191 |
6 | MP0001905_abnormal_dopamine_level | 2.62194458 |
7 | MP0003646_muscle_fatigue | 2.44225862 |
8 | MP0008260_abnormal_autophagy | 2.33255921 |
9 | MP0005408_hypopigmentation | 2.31681493 |
10 | MP0008007_abnormal_cellular_replicative | 2.29333183 |
11 | MP0004957_abnormal_blastocyst_morpholog | 2.22895400 |
12 | MP0006276_abnormal_autonomic_nervous | 2.11873509 |
13 | MP0009046_muscle_twitch | 2.07039063 |
14 | MP0004084_abnormal_cardiac_muscle | 2.03776893 |
15 | MP0002938_white_spotting | 1.97343952 |
16 | MP0008932_abnormal_embryonic_tissue | 1.93350894 |
17 | MP0002163_abnormal_gland_morphology | 1.93027152 |
18 | MP0003136_yellow_coat_color | 1.91917338 |
19 | MP0008877_abnormal_DNA_methylation | 1.91672800 |
20 | MP0003123_paternal_imprinting | 1.87325059 |
21 | MP0001440_abnormal_grooming_behavior | 1.86201934 |
22 | MP0006035_abnormal_mitochondrial_morpho | 1.84816608 |
23 | MP0008875_abnormal_xenobiotic_pharmacok | 1.81644066 |
24 | MP0000749_muscle_degeneration | 1.78733761 |
25 | MP0004036_abnormal_muscle_relaxation | 1.74093329 |
26 | MP0006036_abnormal_mitochondrial_physio | 1.74021457 |
27 | MP0003950_abnormal_plasma_membrane | 1.72183664 |
28 | MP0002837_dystrophic_cardiac_calcinosis | 1.70608554 |
29 | MP0004270_analgesia | 1.66564523 |
30 | MP0003111_abnormal_nucleus_morphology | 1.65941915 |
31 | MP0002734_abnormal_mechanical_nocicepti | 1.64407406 |
32 | MP0003786_premature_aging | 1.63070970 |
33 | MP0002272_abnormal_nervous_system | 1.59768087 |
34 | MP0002736_abnormal_nociception_after | 1.57477664 |
35 | MP0004215_abnormal_myocardial_fiber | 1.55618462 |
36 | MP0005171_absent_coat_pigmentation | 1.55514215 |
37 | MP0001968_abnormal_touch/_nociception | 1.55217909 |
38 | MP0004145_abnormal_muscle_electrophysio | 1.54684546 |
39 | MP0004142_abnormal_muscle_tone | 1.52746657 |
40 | MP0001485_abnormal_pinna_reflex | 1.50168295 |
41 | MP0008057_abnormal_DNA_replication | 1.49603333 |
42 | MP0008058_abnormal_DNA_repair | 1.46298814 |
43 | MP0002064_seizures | 1.42470558 |
44 | MP0003315_abnormal_perineum_morphology | 1.41263305 |
45 | MP0001188_hyperpigmentation | 1.39868101 |
46 | MP0001542_abnormal_bone_strength | 1.37274654 |
47 | MP0000750_abnormal_muscle_regeneration | 1.36987975 |
48 | MP0003077_abnormal_cell_cycle | 1.35183947 |
49 | MP0003878_abnormal_ear_physiology | 1.34301777 |
50 | MP0005377_hearing/vestibular/ear_phenot | 1.34301777 |
51 | MP0005075_abnormal_melanosome_morpholog | 1.33851723 |
52 | MP0003890_abnormal_embryonic-extraembry | 1.31961874 |
53 | MP0009745_abnormal_behavioral_response | 1.31796605 |
54 | MP0000358_abnormal_cell_content/ | 1.31626824 |
55 | MP0002095_abnormal_skin_pigmentation | 1.26858820 |
56 | MP0005330_cardiomyopathy | 1.25705972 |
57 | MP0001486_abnormal_startle_reflex | 1.24904930 |
58 | MP0010094_abnormal_chromosome_stability | 1.24675495 |
59 | MP0000747_muscle_weakness | 1.21884729 |
60 | MP0001764_abnormal_homeostasis | 1.18701104 |
61 | MP0002102_abnormal_ear_morphology | 1.18187378 |
62 | MP0004147_increased_porphyrin_level | 1.18114872 |
63 | MP0004484_altered_response_of | 1.17759966 |
64 | MP0005451_abnormal_body_composition | 1.16987216 |
65 | MP0002090_abnormal_vision | 1.16283796 |
66 | MP0001501_abnormal_sleep_pattern | 1.15819132 |
67 | MP0000350_abnormal_cell_proliferation | 1.15481581 |
68 | MP0001986_abnormal_taste_sensitivity | 1.15356099 |
69 | MP0005253_abnormal_eye_physiology | 1.14953150 |
70 | MP0001661_extended_life_span | 1.14806091 |
71 | MP0005386_behavior/neurological_phenoty | 1.14526697 |
72 | MP0004924_abnormal_behavior | 1.14526697 |
73 | MP0002876_abnormal_thyroid_physiology | 1.13874478 |
74 | MP0004742_abnormal_vestibular_system | 1.13142049 |
75 | MP0000751_myopathy | 1.12739237 |
76 | MP0002735_abnormal_chemical_nociception | 1.11427287 |
77 | MP0002067_abnormal_sensory_capabilities | 1.09537774 |
78 | MP0002572_abnormal_emotion/affect_behav | 1.08979450 |
79 | MP0001727_abnormal_embryo_implantation | 1.08274503 |
80 | MP0008872_abnormal_physiological_respon | 1.07004737 |
81 | MP0005423_abnormal_somatic_nervous | 1.06130457 |
82 | MP0005084_abnormal_gallbladder_morpholo | 1.05887543 |
83 | MP0001697_abnormal_embryo_size | 1.05437035 |
84 | MP0000372_irregular_coat_pigmentation | 1.05041613 |
85 | MP0003635_abnormal_synaptic_transmissio | 1.04986251 |
86 | MP0003137_abnormal_impulse_conducting | 1.04645804 |
87 | MP0003938_abnormal_ear_development | 1.04021737 |
88 | MP0005379_endocrine/exocrine_gland_phen | 1.03585623 |
89 | MP0000015_abnormal_ear_pigmentation | 1.01772782 |
90 | MP0000566_synostosis | 1.01243752 |
91 | MP0001970_abnormal_pain_threshold | 1.00365611 |
92 | MP0005395_other_phenotype | 1.00006977 |
93 | MP0003221_abnormal_cardiomyocyte_apopto | 0.99915597 |
94 | MP0001929_abnormal_gametogenesis | 0.97082756 |
95 | MP0009697_abnormal_copulation | 0.95621614 |
96 | MP0001963_abnormal_hearing_physiology | 0.91587762 |
97 | MP0001324_abnormal_eye_pigmentation | 0.91019553 |
98 | MP0003879_abnormal_hair_cell | 0.90759321 |
99 | MP0002638_abnormal_pupillary_reflex | 0.89651971 |
100 | MP0002106_abnormal_muscle_physiology | 0.89573359 |
101 | MP0006292_abnormal_olfactory_placode | 0.88947790 |
102 | MP0005620_abnormal_muscle_contractility | 0.87655753 |
103 | MP0001293_anophthalmia | 0.87020274 |
104 | MP0002972_abnormal_cardiac_muscle | 0.86645490 |
105 | MP0003195_calcinosis | 0.86471404 |
106 | MP0000647_abnormal_sebaceous_gland | 0.86395226 |
107 | MP0003567_abnormal_fetal_cardiomyocyte | 0.86325652 |
108 | MP0000313_abnormal_cell_death | 0.83913539 |
109 | MP0000920_abnormal_myelination | 0.83576238 |
110 | MP0005551_abnormal_eye_electrophysiolog | 0.83394023 |
111 | MP0006138_congestive_heart_failure | 0.83393233 |
112 | MP0002080_prenatal_lethality | 0.82243037 |
113 | MP0010030_abnormal_orbit_morphology | 0.82124822 |
114 | MP0009379_abnormal_foot_pigmentation | 0.81780746 |
115 | MP0005174_abnormal_tail_pigmentation | 0.81675810 |
116 | MP0006072_abnormal_retinal_apoptosis | 0.81662633 |
117 | MP0002332_abnormal_exercise_endurance | 0.81521627 |
118 | MP0003186_abnormal_redox_activity | 0.81375331 |
119 | MP0004043_abnormal_pH_regulation | 0.80938387 |
120 | MP0005410_abnormal_fertilization | 0.80349969 |
121 | MP0005266_abnormal_metabolism | 0.79936675 |
122 | MP0001730_embryonic_growth_arrest | 0.79616926 |
123 | MP0002063_abnormal_learning/memory/cond | 0.79504790 |
124 | MP0002160_abnormal_reproductive_system | 0.79470520 |
125 | MP0005389_reproductive_system_phenotype | 0.79029691 |
126 | MP0003941_abnormal_skin_development | 0.78695270 |
127 | MP0002229_neurodegeneration | 0.78477547 |
128 | MP0000653_abnormal_sex_gland | 0.78336831 |
129 | MP0003937_abnormal_limbs/digits/tail_de | 0.77563329 |
130 | MP0001672_abnormal_embryogenesis/_devel | 0.77382085 |
131 | MP0005380_embryogenesis_phenotype | 0.77382085 |
132 | MP0005369_muscle_phenotype | 0.77147596 |
133 | MP0002210_abnormal_sex_determination | 0.76929437 |
134 | MP0002234_abnormal_pharynx_morphology | 0.76673383 |
135 | MP0005332_abnormal_amino_acid | 0.76552956 |
136 | MP0002066_abnormal_motor_capabilities/c | 0.75592631 |
137 | MP0001145_abnormal_male_reproductive | 0.74220053 |
138 | MP0002085_abnormal_embryonic_tissue | 0.73183176 |
139 | MP0003011_delayed_dark_adaptation | 0.71039729 |
140 | MP0002084_abnormal_developmental_patter | 0.70164047 |
141 | MP0000371_diluted_coat_color | 0.68502502 |
142 | MP0001881_abnormal_mammary_gland | 0.67359779 |
143 | MP0001119_abnormal_female_reproductive | 0.66830161 |
144 | MP0005187_abnormal_penis_morphology | 0.64203746 |
145 | MP0001853_heart_inflammation | 0.63651970 |
146 | MP0002282_abnormal_trachea_morphology | 0.63230500 |
147 | MP0005197_abnormal_uvea_morphology | 0.60357270 |
148 | MP0010307_abnormal_tumor_latency | 0.58677150 |
149 | MP0000427_abnormal_hair_cycle | 0.58569616 |
150 | MP0001186_pigmentation_phenotype | 0.58188052 |
151 | MP0004233_abnormal_muscle_weight | 0.57068681 |
152 | MP0008995_early_reproductive_senescence | 0.56916367 |
153 | MP0000569_abnormal_digit_pigmentation | 0.55826688 |
154 | MP0001984_abnormal_olfaction | 0.53149514 |
155 | MP0002088_abnormal_embryonic_growth/wei | 0.53093771 |
156 | MP0003698_abnormal_male_reproductive | 0.52921154 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Acute necrotizing encephalopathy (HP:0006965) | 5.40766682 |
2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.80392474 |
3 | Mitochondrial inheritance (HP:0001427) | 4.79128221 |
4 | Progressive macrocephaly (HP:0004481) | 4.43155664 |
5 | Increased CSF lactate (HP:0002490) | 4.36566346 |
6 | Abnormality of glycolysis (HP:0004366) | 4.33265671 |
7 | Increased serum pyruvate (HP:0003542) | 4.33265671 |
8 | Cerebral hypomyelination (HP:0006808) | 4.28535565 |
9 | Hepatocellular necrosis (HP:0001404) | 4.21894322 |
10 | Acute encephalopathy (HP:0006846) | 4.19063610 |
11 | Increased hepatocellular lipid droplets (HP:0006565) | 3.86377556 |
12 | Hepatic necrosis (HP:0002605) | 3.65273907 |
13 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.50559125 |
14 | Breast hypoplasia (HP:0003187) | 3.38417116 |
15 | Carpal bone hypoplasia (HP:0001498) | 3.37883217 |
16 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 3.35014509 |
17 | Lipid accumulation in hepatocytes (HP:0006561) | 3.30187358 |
18 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.25009647 |
19 | 3-Methylglutaconic aciduria (HP:0003535) | 3.21678207 |
20 | Increased serum lactate (HP:0002151) | 3.13599242 |
21 | Birth length less than 3rd percentile (HP:0003561) | 3.11881552 |
22 | Respiratory failure (HP:0002878) | 3.09560124 |
23 | Renal Fanconi syndrome (HP:0001994) | 2.98127107 |
24 | Type I transferrin isoform profile (HP:0003642) | 2.97449161 |
25 | Abnormality of methionine metabolism (HP:0010901) | 2.97075277 |
26 | Exercise intolerance (HP:0003546) | 2.91979479 |
27 | Lactic acidosis (HP:0003128) | 2.89774771 |
28 | Methylmalonic acidemia (HP:0002912) | 2.89561617 |
29 | Parakeratosis (HP:0001036) | 2.78295376 |
30 | Leukodystrophy (HP:0002415) | 2.76106714 |
31 | Cerebral edema (HP:0002181) | 2.74021752 |
32 | Abnormality of the anterior horn cell (HP:0006802) | 2.70256214 |
33 | Degeneration of anterior horn cells (HP:0002398) | 2.70256214 |
34 | CNS hypomyelination (HP:0003429) | 2.69459046 |
35 | Rough bone trabeculation (HP:0100670) | 2.69023815 |
36 | Muscle fiber splitting (HP:0003555) | 2.65859147 |
37 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.65123249 |
38 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.65123249 |
39 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.64276486 |
40 | Abnormality of alanine metabolism (HP:0010916) | 2.64276486 |
41 | Hyperalaninemia (HP:0003348) | 2.64276486 |
42 | Optic disc pallor (HP:0000543) | 2.63706750 |
43 | CNS demyelination (HP:0007305) | 2.59014943 |
44 | Reduced antithrombin III activity (HP:0001976) | 2.57685829 |
45 | Pheochromocytoma (HP:0002666) | 2.57240619 |
46 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.56189147 |
47 | Increased intramyocellular lipid droplets (HP:0012240) | 2.54342475 |
48 | Neuroendocrine neoplasm (HP:0100634) | 2.50604185 |
49 | Irregular epiphyses (HP:0010582) | 2.46055455 |
50 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.45612676 |
51 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.45612676 |
52 | Abnormal protein glycosylation (HP:0012346) | 2.45612676 |
53 | Abnormal glycosylation (HP:0012345) | 2.45612676 |
54 | Aplastic anemia (HP:0001915) | 2.44966356 |
55 | Abnormality of the labia minora (HP:0012880) | 2.44943496 |
56 | Respiratory difficulties (HP:0002880) | 2.43288968 |
57 | Congenital, generalized hypertrichosis (HP:0004540) | 2.39636538 |
58 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.39258687 |
59 | Emotional lability (HP:0000712) | 2.31613116 |
60 | Meckel diverticulum (HP:0002245) | 2.31459091 |
61 | Generalized aminoaciduria (HP:0002909) | 2.30837540 |
62 | Exertional dyspnea (HP:0002875) | 2.25458980 |
63 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 2.23508433 |
64 | Delusions (HP:0000746) | 2.22610241 |
65 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.22402318 |
66 | Abnormality of the ileum (HP:0001549) | 2.22215965 |
67 | Macrocytic anemia (HP:0001972) | 2.21202509 |
68 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.18031913 |
69 | Abnormality of the pons (HP:0007361) | 2.16699278 |
70 | Microvesicular hepatic steatosis (HP:0001414) | 2.14748442 |
71 | Abnormal trabecular bone morphology (HP:0100671) | 2.14685059 |
72 | Abnormality of serum amino acid levels (HP:0003112) | 2.14359123 |
73 | Areflexia of lower limbs (HP:0002522) | 2.14091890 |
74 | Hypoplasia of the pons (HP:0012110) | 2.13746059 |
75 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.11787867 |
76 | Oral leukoplakia (HP:0002745) | 2.10258368 |
77 | Abnormal lung lobation (HP:0002101) | 2.09109012 |
78 | Megaloblastic anemia (HP:0001889) | 2.08711569 |
79 | Focal motor seizures (HP:0011153) | 2.08570109 |
80 | Postnatal microcephaly (HP:0005484) | 2.08026023 |
81 | Hypoplasia of the fovea (HP:0007750) | 2.07249409 |
82 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 2.07249409 |
83 | Abnormality of chromosome stability (HP:0003220) | 2.05055418 |
84 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.04873694 |
85 | Unsteady gait (HP:0002317) | 2.04306884 |
86 | Progressive external ophthalmoplegia (HP:0000590) | 2.03643092 |
87 | Chromsome breakage (HP:0040012) | 2.00613128 |
88 | Ureteral duplication (HP:0000073) | 1.99017267 |
89 | Abnormality of the preputium (HP:0100587) | 1.98777948 |
90 | Increased muscle lipid content (HP:0009058) | 1.97969588 |
91 | Muscle hypertrophy of the lower extremities (HP:0008968) | 1.96631763 |
92 | Multiple enchondromatosis (HP:0005701) | 1.95715387 |
93 | Abnormality of renal resorption (HP:0011038) | 1.95645237 |
94 | Secondary amenorrhea (HP:0000869) | 1.94993491 |
95 | X-linked dominant inheritance (HP:0001423) | 1.94854984 |
96 | Absent radius (HP:0003974) | 1.94741622 |
97 | Short tibia (HP:0005736) | 1.93528080 |
98 | Abnormality of the fovea (HP:0000493) | 1.92384386 |
99 | Volvulus (HP:0002580) | 1.91026676 |
100 | Pancreatic cysts (HP:0001737) | 1.89020807 |
101 | External ophthalmoplegia (HP:0000544) | 1.86735212 |
102 | Lethargy (HP:0001254) | 1.85207295 |
103 | Pancytopenia (HP:0001876) | 1.84581998 |
104 | Aplasia involving forearm bones (HP:0009822) | 1.83417262 |
105 | Absent forearm bone (HP:0003953) | 1.83417262 |
106 | Abnormality of the umbilical cord (HP:0010881) | 1.82528955 |
107 | Testicular atrophy (HP:0000029) | 1.81974533 |
108 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.81894841 |
109 | Absent epiphyses (HP:0010577) | 1.81894841 |
110 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.81766117 |
111 | Sensory axonal neuropathy (HP:0003390) | 1.80835831 |
112 | Adrenal hypoplasia (HP:0000835) | 1.80236669 |
113 | Rimmed vacuoles (HP:0003805) | 1.79117708 |
114 | Methylmalonic aciduria (HP:0012120) | 1.78910839 |
115 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 1.78463880 |
116 | Double outlet right ventricle (HP:0001719) | 1.77998294 |
117 | Congenital malformation of the right heart (HP:0011723) | 1.77998294 |
118 | Pancreatic fibrosis (HP:0100732) | 1.76974271 |
119 | Abnormality of midbrain morphology (HP:0002418) | 1.76894553 |
120 | Molar tooth sign on MRI (HP:0002419) | 1.76894553 |
121 | Amniotic constriction ring (HP:0009775) | 1.76687435 |
122 | Abnormality of placental membranes (HP:0011409) | 1.76687435 |
123 | Patchy hypopigmentation of hair (HP:0011365) | 1.75848626 |
124 | Duodenal stenosis (HP:0100867) | 1.75745467 |
125 | Small intestinal stenosis (HP:0012848) | 1.75745467 |
126 | Impulsivity (HP:0100710) | 1.74863771 |
127 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.73942691 |
128 | Medial flaring of the eyebrow (HP:0010747) | 1.73619954 |
129 | Calf muscle hypertrophy (HP:0008981) | 1.72790693 |
130 | Abnormal number of erythroid precursors (HP:0012131) | 1.71704523 |
131 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.71618045 |
132 | Hyperglycinemia (HP:0002154) | 1.68210797 |
133 | Sparse eyelashes (HP:0000653) | 1.67801615 |
134 | Stenosis of the external auditory canal (HP:0000402) | 1.67734631 |
135 | Palpitations (HP:0001962) | 1.64850985 |
136 | Abnormality of homocysteine metabolism (HP:0010919) | 1.64668146 |
137 | Autoamputation (HP:0001218) | 1.64405137 |
138 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.63987254 |
139 | Spastic paraparesis (HP:0002313) | 1.63793928 |
140 | Patellar aplasia (HP:0006443) | 1.63716809 |
141 | Premature ovarian failure (HP:0008209) | 1.63632339 |
142 | Aplasia of the musculature (HP:0100854) | 1.62856285 |
143 | Split foot (HP:0001839) | 1.60664620 |
144 | Glycosuria (HP:0003076) | 1.59410058 |
145 | Abnormality of urine glucose concentration (HP:0011016) | 1.59410058 |
146 | Progressive muscle weakness (HP:0003323) | 1.58767853 |
147 | Abnormal hair whorl (HP:0010721) | 1.58696508 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BUB1 | 4.63838127 |
2 | VRK2 | 3.09426861 |
3 | STK16 | 3.07411337 |
4 | EIF2AK1 | 2.90204079 |
5 | WEE1 | 2.78357495 |
6 | PNCK | 2.58561312 |
7 | AKT3 | 2.50105522 |
8 | CDC7 | 2.47706469 |
9 | NME1 | 2.45436449 |
10 | TSSK6 | 2.45148728 |
11 | TRIM28 | 2.37941643 |
12 | STK39 | 2.32587481 |
13 | PLK4 | 2.12363999 |
14 | ARAF | 2.09953882 |
15 | SRPK1 | 2.08086111 |
16 | CASK | 1.90518700 |
17 | PBK | 1.85300536 |
18 | OXSR1 | 1.85193992 |
19 | EIF2AK3 | 1.83848640 |
20 | ZAK | 1.82459328 |
21 | NME2 | 1.76377767 |
22 | BRSK2 | 1.68068761 |
23 | BCR | 1.66907621 |
24 | PINK1 | 1.58480790 |
25 | PDK4 | 1.52559591 |
26 | PDK3 | 1.52559591 |
27 | PLK3 | 1.52197061 |
28 | OBSCN | 1.51635489 |
29 | MKNK1 | 1.48488119 |
30 | EPHA2 | 1.43373285 |
31 | MAP3K12 | 1.39713761 |
32 | MKNK2 | 1.39654293 |
33 | VRK1 | 1.39147400 |
34 | PDK2 | 1.33266395 |
35 | MST4 | 1.33243733 |
36 | STK38L | 1.30716276 |
37 | BRAF | 1.30338764 |
38 | CCNB1 | 1.27430184 |
39 | LIMK1 | 1.18147183 |
40 | MYLK | 1.16488360 |
41 | ERBB3 | 1.10321362 |
42 | BRSK1 | 1.08685284 |
43 | PLK1 | 1.05621707 |
44 | NEK6 | 1.05207468 |
45 | PLK2 | 1.02753451 |
46 | PIM2 | 0.99674703 |
47 | TNIK | 0.99642030 |
48 | TTK | 0.97373147 |
49 | AURKA | 0.95519913 |
50 | WNK4 | 0.94719252 |
51 | TAF1 | 0.91957734 |
52 | NEK1 | 0.91179848 |
53 | MUSK | 0.90243358 |
54 | EIF2AK2 | 0.89410143 |
55 | MAP2K7 | 0.87288386 |
56 | GRK7 | 0.84768478 |
57 | TLK1 | 0.80966742 |
58 | MAPKAPK5 | 0.80960968 |
59 | STK24 | 0.80347489 |
60 | IRAK3 | 0.79749370 |
61 | CSNK1G3 | 0.79748154 |
62 | WNK3 | 0.77557511 |
63 | CAMK2D | 0.77382435 |
64 | CAMK2B | 0.73771058 |
65 | ATR | 0.73514161 |
66 | TESK2 | 0.70593963 |
67 | ERBB4 | 0.68415416 |
68 | STK3 | 0.67377060 |
69 | MARK1 | 0.67132691 |
70 | ADRBK2 | 0.66943257 |
71 | GRK5 | 0.65970218 |
72 | DYRK2 | 0.65663124 |
73 | MAP4K2 | 0.64954414 |
74 | CHEK2 | 0.61523994 |
75 | FRK | 0.61013014 |
76 | CAMK2G | 0.59143740 |
77 | EPHA4 | 0.58986936 |
78 | SIK3 | 0.58703304 |
79 | BCKDK | 0.58639356 |
80 | BMPR1B | 0.58357492 |
81 | ALK | 0.57879984 |
82 | CDK19 | 0.57414694 |
83 | PRKCG | 0.57210420 |
84 | LATS2 | 0.56743923 |
85 | ACVR1B | 0.55661110 |
86 | GRK1 | 0.54897362 |
87 | PAK4 | 0.54651458 |
88 | CAMK2A | 0.53014296 |
89 | CDK7 | 0.52833776 |
90 | MAP3K4 | 0.52790657 |
91 | BMPR2 | 0.52679284 |
92 | PAK1 | 0.52547845 |
93 | AURKB | 0.51733103 |
94 | STK4 | 0.51386726 |
95 | ABL2 | 0.51067024 |
96 | CHEK1 | 0.50616689 |
97 | ATM | 0.50234975 |
98 | NUAK1 | 0.50229002 |
99 | TGFBR2 | 0.50037975 |
100 | CAMKK2 | 0.49040857 |
101 | CDK3 | 0.48551519 |
102 | CSNK2A1 | 0.47837596 |
103 | CSNK1G1 | 0.47387087 |
104 | RPS6KA5 | 0.47256362 |
105 | PRKCE | 0.47241618 |
106 | PRKCI | 0.47080334 |
107 | CSNK2A2 | 0.46856791 |
108 | INSRR | 0.45728372 |
109 | ILK | 0.44541803 |
110 | MST1R | 0.44466833 |
111 | CDK14 | 0.43278404 |
112 | CLK1 | 0.42662392 |
113 | CSNK1G2 | 0.41860631 |
114 | TGFBR1 | 0.41295457 |
115 | PKN1 | 0.39314580 |
116 | CSNK1A1 | 0.38925814 |
117 | NTRK3 | 0.36478782 |
118 | CSNK1E | 0.36191445 |
119 | NEK2 | 0.34906347 |
120 | PASK | 0.34703976 |
121 | CSNK1A1L | 0.34327788 |
122 | DAPK1 | 0.33556651 |
123 | CDK18 | 0.32378391 |
124 | PRKACA | 0.32280024 |
125 | STK10 | 0.31388240 |
126 | ROCK2 | 0.30451428 |
127 | PAK3 | 0.29826675 |
128 | CDK15 | 0.29113363 |
129 | MINK1 | 0.28723074 |
130 | CDK1 | 0.28591363 |
131 | CDK8 | 0.27076891 |
132 | ADRBK1 | 0.25315164 |
133 | FGFR1 | 0.23357600 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Proteasome_Homo sapiens_hsa03050 | 4.83127132 |
2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.63409997 |
3 | RNA polymerase_Homo sapiens_hsa03020 | 4.16392876 |
4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.92136744 |
5 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 3.40856308 |
6 | Huntingtons disease_Homo sapiens_hsa05016 | 3.02928237 |
7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.01471425 |
8 | Alzheimers disease_Homo sapiens_hsa05010 | 2.76163361 |
9 | Ribosome_Homo sapiens_hsa03010 | 2.68045369 |
10 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.47909371 |
11 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.19715291 |
12 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.10705498 |
13 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.96213888 |
14 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.93447917 |
15 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.92470095 |
16 | Basal transcription factors_Homo sapiens_hsa03022 | 1.86906352 |
17 | RNA transport_Homo sapiens_hsa03013 | 1.85598772 |
18 | Protein export_Homo sapiens_hsa03060 | 1.85333380 |
19 | Spliceosome_Homo sapiens_hsa03040 | 1.62303566 |
20 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.60764742 |
21 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.59036787 |
22 | Homologous recombination_Homo sapiens_hsa03440 | 1.58316581 |
23 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.52917347 |
24 | Purine metabolism_Homo sapiens_hsa00230 | 1.50735646 |
25 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.42673657 |
26 | Mismatch repair_Homo sapiens_hsa03430 | 1.31457713 |
27 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.31363192 |
28 | DNA replication_Homo sapiens_hsa03030 | 1.28920963 |
29 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.23703767 |
30 | Sulfur relay system_Homo sapiens_hsa04122 | 1.22167225 |
31 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.19646321 |
32 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.16764396 |
33 | Nicotine addiction_Homo sapiens_hsa05033 | 1.10750341 |
34 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.09394073 |
35 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.02893405 |
36 | RNA degradation_Homo sapiens_hsa03018 | 1.02651936 |
37 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.00812919 |
38 | Cell cycle_Homo sapiens_hsa04110 | 0.98146266 |
39 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.97552140 |
40 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.96734919 |
41 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.95960902 |
42 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.95721713 |
43 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.94113525 |
44 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.89935584 |
45 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.89734878 |
46 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.83935000 |
47 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.83842971 |
48 | Metabolic pathways_Homo sapiens_hsa01100 | 0.80794965 |
49 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.80712674 |
50 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.80201615 |
51 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.78513593 |
52 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.72191030 |
53 | Phototransduction_Homo sapiens_hsa04744 | 0.70608802 |
54 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.68867045 |
55 | Carbon metabolism_Homo sapiens_hsa01200 | 0.67094829 |
56 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.65929763 |
57 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.64052748 |
58 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.62984613 |
59 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.62368309 |
60 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.62348514 |
61 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.60802623 |
62 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.59624508 |
63 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.59540711 |
64 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.58784273 |
65 | Base excision repair_Homo sapiens_hsa03410 | 0.58407860 |
66 | Peroxisome_Homo sapiens_hsa04146 | 0.58319946 |
67 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.57835119 |
68 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.55996963 |
69 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.55885422 |
70 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.54955203 |
71 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.54271638 |
72 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.54152931 |
73 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.53375455 |
74 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.53242203 |
75 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.52368854 |
76 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.51213068 |
77 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.50863307 |
78 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.49900097 |
79 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.48723056 |
80 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.48561449 |
81 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.48161905 |
82 | Taste transduction_Homo sapiens_hsa04742 | 0.46652754 |
83 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.45434204 |
84 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.43841227 |
85 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.43015375 |
86 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.42513072 |
87 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.42382032 |
88 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.41446920 |
89 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.40049872 |
90 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.38914601 |
91 | GABAergic synapse_Homo sapiens_hsa04727 | 0.38780768 |
92 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.38690102 |
93 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.38511581 |
94 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.38147150 |
95 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.36606567 |
96 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.35931293 |
97 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.35051686 |
98 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.34979285 |
99 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.32800359 |
100 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.32666900 |
101 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.32196736 |
102 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.32123057 |
103 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.31768797 |
104 | Circadian rhythm_Homo sapiens_hsa04710 | 0.31278281 |
105 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.28978282 |
106 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.28773466 |
107 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.28281455 |
108 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.28032634 |
109 | Phagosome_Homo sapiens_hsa04145 | 0.27449401 |
110 | Mineral absorption_Homo sapiens_hsa04978 | 0.26841305 |
111 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.25381347 |
112 | Tight junction_Homo sapiens_hsa04530 | 0.24791231 |
113 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.23506880 |
114 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.23022567 |
115 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.22289125 |
116 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.21500260 |
117 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.20517121 |
118 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.19266839 |
119 | Morphine addiction_Homo sapiens_hsa05032 | 0.18940254 |
120 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.18517185 |
121 | Retinol metabolism_Homo sapiens_hsa00830 | 0.17078239 |
122 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.15003620 |
123 | Legionellosis_Homo sapiens_hsa05134 | 0.14638220 |
124 | Long-term depression_Homo sapiens_hsa04730 | 0.14636082 |
125 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.12816736 |
126 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.11481819 |
127 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.11268258 |
128 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.09322013 |
129 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.08778112 |
130 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.07680713 |