TIMM17B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multipass transmembrane protein that forms an integral component of the mitochondrial translocase TIM23 complex. This complex facilitates the transport of mitochondrial proteins from the cytosol across the mitochondrial inner membrane and into the mitochondrion. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.66492658
2ATP synthesis coupled proton transport (GO:0015986)6.40079333
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.40079333
4DNA deamination (GO:0045006)5.92035921
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.64786520
6ribosomal small subunit assembly (GO:0000028)5.63112508
7viral transcription (GO:0019083)5.45531332
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.43018321
9proteasome assembly (GO:0043248)5.32332714
10respiratory electron transport chain (GO:0022904)5.27701227
11translational termination (GO:0006415)5.25368852
12electron transport chain (GO:0022900)5.20781791
13ribosomal small subunit biogenesis (GO:0042274)5.16363481
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.95266703
15maturation of SSU-rRNA (GO:0030490)4.86539877
16mitochondrial respiratory chain complex assembly (GO:0033108)4.86086005
17cotranslational protein targeting to membrane (GO:0006613)4.83323418
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.81484821
19mitochondrial respiratory chain complex I assembly (GO:0032981)4.81484821
20NADH dehydrogenase complex assembly (GO:0010257)4.81484821
21protein targeting to ER (GO:0045047)4.80261280
22chaperone-mediated protein transport (GO:0072321)4.78592322
23protein neddylation (GO:0045116)4.62746647
24translational elongation (GO:0006414)4.56186525
25protein localization to endoplasmic reticulum (GO:0070972)4.53758833
26establishment of protein localization to endoplasmic reticulum (GO:0072599)4.53750765
27telomere maintenance via semi-conservative replication (GO:0032201)4.52303689
28ribosomal large subunit biogenesis (GO:0042273)4.46508640
29translational initiation (GO:0006413)4.15220205
30termination of RNA polymerase III transcription (GO:0006386)4.09220650
31transcription elongation from RNA polymerase III promoter (GO:0006385)4.09220650
32viral life cycle (GO:0019058)4.07427073
33rRNA modification (GO:0000154)4.06033196
34nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.05180819
35DNA strand elongation involved in DNA replication (GO:0006271)4.04145326
36cellular protein complex disassembly (GO:0043624)4.03919258
37cytochrome complex assembly (GO:0017004)3.98955677
38ATP biosynthetic process (GO:0006754)3.93989937
39translation (GO:0006412)3.93588204
40DNA strand elongation (GO:0022616)3.91111505
41telomere maintenance via recombination (GO:0000722)3.90374404
42purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.88120360
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.86843854
44purine nucleoside triphosphate biosynthetic process (GO:0009145)3.84851351
45ribonucleoprotein complex biogenesis (GO:0022613)3.82511880
46regulation of mitochondrial translation (GO:0070129)3.79068009
47* protein targeting to mitochondrion (GO:0006626)3.76837795
48tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.76089293
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.76089293
50GTP biosynthetic process (GO:0006183)3.69533365
51* establishment of protein localization to mitochondrion (GO:0072655)3.69173160
52regulation of nuclear cell cycle DNA replication (GO:0033262)3.64315027
53pseudouridine synthesis (GO:0001522)3.63367986
54transcription-coupled nucleotide-excision repair (GO:0006283)3.61014728
55peptidyl-histidine modification (GO:0018202)3.59752747
56pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.59572259
57ribonucleoside triphosphate biosynthetic process (GO:0009201)3.57639335
58hydrogen ion transmembrane transport (GO:1902600)3.56304059
59protein complex disassembly (GO:0043241)3.55865529
60telomere maintenance via telomere lengthening (GO:0010833)3.54241545
61spliceosomal snRNP assembly (GO:0000387)3.52569208
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.51773159
63mitotic recombination (GO:0006312)3.49928423
64oxidative phosphorylation (GO:0006119)3.48576010
65DNA replication checkpoint (GO:0000076)3.48247805
66* protein localization to mitochondrion (GO:0070585)3.47343774
67guanosine-containing compound biosynthetic process (GO:1901070)3.46663534
68rRNA processing (GO:0006364)3.46356229
69nucleotide-excision repair, DNA gap filling (GO:0006297)3.45201127
70DNA replication initiation (GO:0006270)3.43433180
71protein-cofactor linkage (GO:0018065)3.41922237
72macromolecular complex disassembly (GO:0032984)3.39715501
73UTP biosynthetic process (GO:0006228)3.37667654
74rRNA methylation (GO:0031167)3.36546380
75cellular component biogenesis (GO:0044085)3.35832618
76rRNA metabolic process (GO:0016072)3.33915585
77positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.30475116
787-methylguanosine mRNA capping (GO:0006370)3.30070366
79mannosylation (GO:0097502)3.29680625
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.28351276
81DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.27057014
82signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.25552200
83signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.25552200
84signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.25552200
857-methylguanosine RNA capping (GO:0009452)3.23985579
86RNA capping (GO:0036260)3.23985579
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.23488353
88kinetochore assembly (GO:0051382)3.22656126
89nucleoside triphosphate biosynthetic process (GO:0009142)3.22418674
90sequestering of actin monomers (GO:0042989)3.22080749
91inner mitochondrial membrane organization (GO:0007007)3.21175826
92intracellular protein transmembrane import (GO:0044743)3.21142848
93formation of translation preinitiation complex (GO:0001731)3.20681202
94proton transport (GO:0015992)3.20181788
95spliceosomal complex assembly (GO:0000245)3.19880385
96intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.19616929
97signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.19616929
98regulation of cellular amino acid metabolic process (GO:0006521)3.17461848
99negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16996837
100negative regulation of ligase activity (GO:0051352)3.16996837
101nuclear-transcribed mRNA catabolic process (GO:0000956)3.15173047
102signal transduction involved in DNA integrity checkpoint (GO:0072401)3.14803995
103signal transduction involved in DNA damage checkpoint (GO:0072422)3.14803995
104regulation of double-strand break repair via homologous recombination (GO:0010569)3.14712850
105signal transduction involved in cell cycle checkpoint (GO:0072395)3.14105965
106hydrogen transport (GO:0006818)3.12577144
107pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.12264465
108ribosome biogenesis (GO:0042254)3.11876767
109tRNA methylation (GO:0030488)3.11444113
110UTP metabolic process (GO:0046051)3.10742841
111antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.09841078
112exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09737825
113* mitochondrial transport (GO:0006839)3.08404533
114L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.07311853
115respiratory chain complex IV assembly (GO:0008535)3.05543226
116cullin deneddylation (GO:0010388)3.04973096
117nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02820072
118protein deneddylation (GO:0000338)3.02749599
119mRNA catabolic process (GO:0006402)3.00953518
120CTP metabolic process (GO:0046036)3.00053295
121CTP biosynthetic process (GO:0006241)3.00053295
122CENP-A containing nucleosome assembly (GO:0034080)2.99357852
123transcription from RNA polymerase I promoter (GO:0006360)2.98939625
124protein maturation by protein folding (GO:0022417)2.98886190
125pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.98231597
126GMP metabolic process (GO:0046037)2.98022426
127nucleobase biosynthetic process (GO:0046112)2.97538950
128pyrimidine nucleotide catabolic process (GO:0006244)2.97362428
129purine nucleoside monophosphate biosynthetic process (GO:0009127)2.95718451
130metallo-sulfur cluster assembly (GO:0031163)2.94701145
131iron-sulfur cluster assembly (GO:0016226)2.94701145
132purine nucleobase biosynthetic process (GO:0009113)2.93319810
133protein targeting to membrane (GO:0006612)2.92802097
134termination of RNA polymerase I transcription (GO:0006363)2.92072471
135protein complex biogenesis (GO:0070271)2.91146309
136DNA damage response, detection of DNA damage (GO:0042769)2.90928465
137antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.90304458
138chromatin remodeling at centromere (GO:0031055)2.89519316
139transcription elongation from RNA polymerase I promoter (GO:0006362)2.88704028
140kinetochore organization (GO:0051383)2.87232769
141L-methionine salvage (GO:0071267)2.87110602
142L-methionine biosynthetic process (GO:0071265)2.87110602
143amino acid salvage (GO:0043102)2.87110602
144RNA catabolic process (GO:0006401)2.85434291
145pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.83628155
146viral mRNA export from host cell nucleus (GO:0046784)2.81870618
147positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.80976998
148deoxyribonucleotide biosynthetic process (GO:0009263)2.80447006

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.09111665
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.28570867
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.16344831
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.83609946
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.78500382
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.60124000
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49163841
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.43466313
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.42244622
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.18309396
11ELF1_17652178_ChIP-ChIP_JURKAT_Human3.16937305
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.12218343
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.01667696
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.90145728
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.84986327
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82474938
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.78607122
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71931561
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69574446
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67549677
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63459937
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57413778
23* VDR_23849224_ChIP-Seq_CD4+_Human2.50426011
24DCP1A_22483619_ChIP-Seq_HELA_Human2.29596089
25YY1_21170310_ChIP-Seq_MESCs_Mouse2.28664967
26XRN2_22483619_ChIP-Seq_HELA_Human2.28130072
27* FOXP3_21729870_ChIP-Seq_TREG_Human2.25324537
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.24720916
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.18237871
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03995586
31GABP_19822575_ChIP-Seq_HepG2_Human2.01247262
32TTF2_22483619_ChIP-Seq_HELA_Human1.99105470
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.97892867
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.96675013
35* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86944677
36* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.84800409
37* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83854466
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77703476
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.76554093
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.74598351
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.72366594
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72009279
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71612431
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71245136
45ELK1_19687146_ChIP-ChIP_HELA_Human1.70093809
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66470849
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.66393535
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62345756
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.61912293
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58298259
51CIITA_25753668_ChIP-Seq_RAJI_Human1.56145806
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54277264
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48581482
54* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46978054
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45640462
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45015395
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41441034
58MYC_18940864_ChIP-ChIP_HL60_Human1.40045917
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.35978720
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33773842
61* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30768685
62FOXP1_21924763_ChIP-Seq_HESCs_Human1.29337352
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.28540339
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26267750
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25658516
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25363816
67ZNF274_21170338_ChIP-Seq_K562_Hela1.24971367
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23673768
69ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22493071
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21094701
71IRF1_19129219_ChIP-ChIP_H3396_Human1.20336330
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17908660
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16922742
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15503650
75SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15129658
76KDM5A_27292631_Chip-Seq_BREAST_Human1.10076813
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09902405
78TET1_21451524_ChIP-Seq_MESCs_Mouse1.08540144
79* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05327229
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02202017
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01613758
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01530871
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01243616
84SPI1_23547873_ChIP-Seq_NB4_Human1.00197592
85PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.00062275
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99087035
87CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97830394
88RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96840413
89* ELF1_20517297_ChIP-Seq_JURKAT_Human0.95375823
90SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94122607
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92916153
92SOX2_16153702_ChIP-ChIP_HESCs_Human0.92325744
93BCL6_27268052_Chip-Seq_Bcells_Human0.91399154
94PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90659738
95PHF8_20622854_ChIP-Seq_HELA_Human0.89697292
96CTCF_26484167_Chip-Seq_Bcells_Mouse0.89343801
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88568004
98IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.88342825
99E2F1_20622854_ChIP-Seq_HELA_Human0.87695167
100AR_21909140_ChIP-Seq_LNCAP_Human0.86145234
101ERA_21632823_ChIP-Seq_H3396_Human0.85287295
102KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.84726598
103KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.84726598
104KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.84726598
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84639505
106DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84280352
107YY1_22570637_ChIP-Seq_MALME-3M_Human0.83346364
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83300512
109TP53_22573176_ChIP-Seq_HFKS_Human0.82868146
110P68_20966046_ChIP-Seq_HELA_Human0.82565526
111* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81777464
112HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81740200
113STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80276120
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78649464
115* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78602310
116SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.76939385
117EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.76653871
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.76235077
119RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.76088034
120OCT4_18692474_ChIP-Seq_MEFs_Mouse0.74870190

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.60620091
2MP0009379_abnormal_foot_pigmentation3.56686322
3MP0006292_abnormal_olfactory_placode3.27691879
4MP0003111_abnormal_nucleus_morphology3.18648180
5MP0008058_abnormal_DNA_repair2.99210815
6MP0004957_abnormal_blastocyst_morpholog2.98276613
7MP0010094_abnormal_chromosome_stability2.89550838
8MP0002837_dystrophic_cardiac_calcinosis2.75268801
9MP0002132_abnormal_respiratory_system2.73229542
10MP0003077_abnormal_cell_cycle2.69069660
11MP0008057_abnormal_DNA_replication2.60142519
12MP0008007_abnormal_cellular_replicative2.39219624
13MP0008932_abnormal_embryonic_tissue2.38710338
14MP0002653_abnormal_ependyma_morphology2.24433000
15MP0003786_premature_aging2.12326371
16MP0003718_maternal_effect1.92313433
17MP0003186_abnormal_redox_activity1.84999272
18MP0003136_yellow_coat_color1.82324483
19MP0009333_abnormal_splenocyte_physiolog1.81585628
20MP0002277_abnormal_respiratory_mucosa1.78028535
21MP0005075_abnormal_melanosome_morpholog1.75972472
22MP0000490_abnormal_crypts_of1.74949208
23MP0001188_hyperpigmentation1.73086656
24MP0004147_increased_porphyrin_level1.71347419
25MP0005174_abnormal_tail_pigmentation1.68103942
26MP0006072_abnormal_retinal_apoptosis1.66895209
27MP0004142_abnormal_muscle_tone1.66100146
28MP0002396_abnormal_hematopoietic_system1.65122048
29MP0000015_abnormal_ear_pigmentation1.64898685
30MP0002102_abnormal_ear_morphology1.63750375
31MP0002736_abnormal_nociception_after1.62866666
32MP0003646_muscle_fatigue1.58117067
33MP0005499_abnormal_olfactory_system1.54986773
34MP0005394_taste/olfaction_phenotype1.54986773
35MP0005645_abnormal_hypothalamus_physiol1.52541589
36MP0003787_abnormal_imprinting1.52369890
37MP0008877_abnormal_DNA_methylation1.52356103
38MP0001905_abnormal_dopamine_level1.50318652
39MP0002938_white_spotting1.49660155
40MP0000678_abnormal_parathyroid_gland1.48328928
41MP0002234_abnormal_pharynx_morphology1.44544262
42MP0006276_abnormal_autonomic_nervous1.43769557
43MP0003121_genomic_imprinting1.42344270
44MP0003315_abnormal_perineum_morphology1.41729139
45MP0001986_abnormal_taste_sensitivity1.41009833
46MP0003806_abnormal_nucleotide_metabolis1.39464513
47MP0003122_maternal_imprinting1.39253248
48MP0003763_abnormal_thymus_physiology1.39209861
49MP0001968_abnormal_touch/_nociception1.38946421
50MP0001764_abnormal_homeostasis1.37505945
51MP0002163_abnormal_gland_morphology1.33944592
52MP0000631_abnormal_neuroendocrine_gland1.33301605
53MP0009046_muscle_twitch1.32191837
54MP0005646_abnormal_pituitary_gland1.30418183
55MP0003724_increased_susceptibility_to1.30346985
56MP0002095_abnormal_skin_pigmentation1.29925109
57MP0005084_abnormal_gallbladder_morpholo1.29615379
58MP0006036_abnormal_mitochondrial_physio1.29553595
59MP0000049_abnormal_middle_ear1.25643852
60MP0008875_abnormal_xenobiotic_pharmacok1.25416430
61MP0008789_abnormal_olfactory_epithelium1.24057825
62MP0002638_abnormal_pupillary_reflex1.21828275
63MP0003941_abnormal_skin_development1.19239405
64MP0009785_altered_susceptibility_to1.16625327
65MP0002822_catalepsy1.16081626
66MP0001346_abnormal_lacrimal_gland1.14947444
67MP0005551_abnormal_eye_electrophysiolog1.13722547
68MP0004381_abnormal_hair_follicle1.12656442
69MP0005379_endocrine/exocrine_gland_phen1.12615623
70MP0005451_abnormal_body_composition1.12473124
71MP0000313_abnormal_cell_death1.12222558
72MP0004145_abnormal_muscle_electrophysio1.09946827
73MP0004133_heterotaxia1.09383782
74MP0000613_abnormal_salivary_gland1.08720279
75MP0002019_abnormal_tumor_incidence1.06349919
76MP0005253_abnormal_eye_physiology1.05342566
77MP0010030_abnormal_orbit_morphology1.04227988
78MP0008872_abnormal_physiological_respon1.03492160
79MP0005332_abnormal_amino_acid1.02580604
80MP0005220_abnormal_exocrine_pancreas1.01893872
81MP0009697_abnormal_copulation1.01780010
82MP0000858_altered_metastatic_potential1.01719895
83MP0004742_abnormal_vestibular_system1.01592844
84MP0001835_abnormal_antigen_presentation1.00645201
85MP0008995_early_reproductive_senescence1.00266236
86MP0000566_synostosis0.98830431
87MP0005671_abnormal_response_to0.98553689
88MP0008260_abnormal_autophagy0.97833672
89MP0001984_abnormal_olfaction0.97760902
90MP0000350_abnormal_cell_proliferation0.96442079
91MP0001929_abnormal_gametogenesis0.96342125
92MP0000372_irregular_coat_pigmentation0.94411409
93MP0002210_abnormal_sex_determination0.93895852
94MP0002160_abnormal_reproductive_system0.92920847
95MP0001919_abnormal_reproductive_system0.91895834
96MP0005389_reproductive_system_phenotype0.90731136
97MP0009745_abnormal_behavioral_response0.90679539
98MP0001119_abnormal_female_reproductive0.90329850
99MP0003137_abnormal_impulse_conducting0.89470527
100MP0000358_abnormal_cell_content/0.89373563
101MP0002148_abnormal_hypersensitivity_rea0.89264745
102MP0000465_gastrointestinal_hemorrhage0.88387005
103MP0003698_abnormal_male_reproductive0.88178579
104MP0002722_abnormal_immune_system0.87706957
105MP0000689_abnormal_spleen_morphology0.87499879
106MP0002751_abnormal_autonomic_nervous0.87439946
107MP0002398_abnormal_bone_marrow0.87201550
108MP0003880_abnormal_central_pattern0.86166244
109MP0003011_delayed_dark_adaptation0.85877448
110MP0006035_abnormal_mitochondrial_morpho0.85126668
111MP0003123_paternal_imprinting0.83563286
112MP0001186_pigmentation_phenotype0.82872465
113MP0005423_abnormal_somatic_nervous0.82100005
114MP0005636_abnormal_mineral_homeostasis0.81793421
115MP0005025_abnormal_response_to0.81724660
116MP0000703_abnormal_thymus_morphology0.81079218
117MP0003195_calcinosis0.80574566
118MP0005410_abnormal_fertilization0.80217181
119MP0002429_abnormal_blood_cell0.80117188
120MP0001800_abnormal_humoral_immune0.78017393
121MP0001145_abnormal_male_reproductive0.77293741
122MP0005409_darkened_coat_color0.74073156
123MP0001944_abnormal_pancreas_morphology0.74052633
124MP0005408_hypopigmentation0.73938350
125MP0002272_abnormal_nervous_system0.73802835
126MP0003119_abnormal_digestive_system0.73600479
127MP0000716_abnormal_immune_system0.72798462
128MP0002752_abnormal_somatic_nervous0.71952787
129MP0003436_decreased_susceptibility_to0.71217486
130MP0005083_abnormal_biliary_tract0.70940746
131MP0000026_abnormal_inner_ear0.70922774
132MP0000750_abnormal_muscle_regeneration0.70662853
133MP0001970_abnormal_pain_threshold0.70472349
134MP0003938_abnormal_ear_development0.70181979
135MP0004019_abnormal_vitamin_homeostasis0.69883070
136MP0001545_abnormal_hematopoietic_system0.69849207
137MP0005397_hematopoietic_system_phenotyp0.69849207
138MP0002557_abnormal_social/conspecific_i0.69249476
139MP0000653_abnormal_sex_gland0.68355008
140MP0001293_anophthalmia0.67590148
141MP0002723_abnormal_immune_serum0.66341285
142MP0002405_respiratory_system_inflammati0.65858952
143MP0002420_abnormal_adaptive_immunity0.65198445
144MP0002177_abnormal_outer_ear0.64722720
145MP0002111_abnormal_tail_morphology0.64688040
146MP0001819_abnormal_immune_cell0.64393993
147MP0002452_abnormal_antigen_presenting0.63543368
148MP0001529_abnormal_vocalization0.63138138

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.50507966
2Abnormality of cells of the erythroid lineage (HP:0012130)4.44163206
3Abnormal number of erythroid precursors (HP:0012131)4.41821395
4Aplasia/Hypoplasia of the sacrum (HP:0008517)3.75643749
5Macrocytic anemia (HP:0001972)3.64246307
6Pallor (HP:0000980)3.63247426
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.55903874
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.53893953
9Decreased activity of mitochondrial respiratory chain (HP:0008972)3.53893953
10Type I transferrin isoform profile (HP:0003642)3.50191732
11Aplastic anemia (HP:0001915)3.45574175
12Hepatocellular necrosis (HP:0001404)3.35258118
13Hepatic necrosis (HP:0002605)3.28714288
14Chromsome breakage (HP:0040012)3.25801164
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.24204157
16Mitochondrial inheritance (HP:0001427)3.17784137
17Increased hepatocellular lipid droplets (HP:0006565)3.06411242
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.04563491
19Birth length less than 3rd percentile (HP:0003561)3.04015973
20Microvesicular hepatic steatosis (HP:0001414)3.01389185
213-Methylglutaconic aciduria (HP:0003535)2.99215799
22Oral leukoplakia (HP:0002745)2.92216403
23Acute necrotizing encephalopathy (HP:0006965)2.89218688
24Increased serum lactate (HP:0002151)2.85149990
25Exertional dyspnea (HP:0002875)2.79955075
26Increased CSF lactate (HP:0002490)2.79213702
27Breast hypoplasia (HP:0003187)2.78319084
28Lipid accumulation in hepatocytes (HP:0006561)2.78273817
29Absent thumb (HP:0009777)2.76284620
30Renal Fanconi syndrome (HP:0001994)2.73677583
31Abnormality of the preputium (HP:0100587)2.73339969
32Reduced antithrombin III activity (HP:0001976)2.70527906
33Meckel diverticulum (HP:0002245)2.68366893
34Rough bone trabeculation (HP:0100670)2.68334060
35Optic disc pallor (HP:0000543)2.67152766
36Abnormal mitochondria in muscle tissue (HP:0008316)2.62922177
37Abnormality of the ileum (HP:0001549)2.61396835
38Duplicated collecting system (HP:0000081)2.56633841
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.44263141
40Pancreatic fibrosis (HP:0100732)2.40877610
41Abnormality of pyrimidine metabolism (HP:0004353)2.40159239
42Pancytopenia (HP:0001876)2.40156957
43Abnormality of the renal collecting system (HP:0004742)2.39394871
44Leukodystrophy (HP:0002415)2.39208408
45Degeneration of anterior horn cells (HP:0002398)2.39202974
46Abnormality of the anterior horn cell (HP:0006802)2.39202974
47Methylmalonic aciduria (HP:0012120)2.38688807
48Sclerocornea (HP:0000647)2.37072993
49Triphalangeal thumb (HP:0001199)2.36961949
50Lethargy (HP:0001254)2.36230030
51Abnormal glycosylation (HP:0012345)2.34261255
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.34261255
53Abnormal protein N-linked glycosylation (HP:0012347)2.34261255
54Abnormal protein glycosylation (HP:0012346)2.34261255
55Acute encephalopathy (HP:0006846)2.32839197
56Abnormality of the heme biosynthetic pathway (HP:0010472)2.31721456
57Absent rod-and cone-mediated responses on ERG (HP:0007688)2.31687177
58Premature graying of hair (HP:0002216)2.29383580
59Pancreatic cysts (HP:0001737)2.28865814
60Patellar aplasia (HP:0006443)2.28141687
61Increased intramyocellular lipid droplets (HP:0012240)2.25659991
62Abnormality of midbrain morphology (HP:0002418)2.23076699
63Molar tooth sign on MRI (HP:0002419)2.23076699
64X-linked dominant inheritance (HP:0001423)2.22341905
65Bone marrow hypocellularity (HP:0005528)2.20631544
66Aplasia/Hypoplasia of the patella (HP:0006498)2.20261981
67Lactic acidosis (HP:0003128)2.18207924
68True hermaphroditism (HP:0010459)2.15604285
69Poor suck (HP:0002033)2.14819601
70Abnormality of the labia minora (HP:0012880)2.12358771
71Horseshoe kidney (HP:0000085)2.08659641
72Exercise intolerance (HP:0003546)2.08541075
73Progressive macrocephaly (HP:0004481)2.08117505
74Abnormality of chromosome stability (HP:0003220)2.07592921
75Abnormal trabecular bone morphology (HP:0100671)2.07277720
7611 pairs of ribs (HP:0000878)2.07205949
77CNS demyelination (HP:0007305)2.06987293
78Hyperglycinemia (HP:0002154)2.06079136
79Emotional lability (HP:0000712)2.05941371
80Abnormality of DNA repair (HP:0003254)2.03175083
81Abnormality of dicarboxylic acid metabolism (HP:0010995)2.01056182
82Dicarboxylic aciduria (HP:0003215)2.01056182
83Muscle fiber atrophy (HP:0100295)1.99581539
84Secondary amenorrhea (HP:0000869)1.97623894
85Cerebral hypomyelination (HP:0006808)1.96430785
86Microretrognathia (HP:0000308)1.95332472
87Testicular atrophy (HP:0000029)1.95119693
88Abnormality of alanine metabolism (HP:0010916)1.93908465
89Hyperalaninemia (HP:0003348)1.93908465
90Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93908465
91Aplasia/hypoplasia of the uterus (HP:0008684)1.93536362
92Medial flaring of the eyebrow (HP:0010747)1.91396267
93Increased muscle lipid content (HP:0009058)1.90870069
94Type II lissencephaly (HP:0007260)1.89391042
95Absent radius (HP:0003974)1.88753275
96Methylmalonic acidemia (HP:0002912)1.87908300
97Cleft eyelid (HP:0000625)1.87791075
98Hypoplasia of the radius (HP:0002984)1.87588146
99Type 2 muscle fiber atrophy (HP:0003554)1.86484950
100Abnormality of reticulocytes (HP:0004312)1.85634204
101Respiratory difficulties (HP:0002880)1.84018448
102Petechiae (HP:0000967)1.83638328
103Abnormality of renal resorption (HP:0011038)1.83032332
104Sparse eyelashes (HP:0000653)1.83016314
105Concave nail (HP:0001598)1.82387174
106Respiratory failure (HP:0002878)1.81287971
107Abnormal hemoglobin (HP:0011902)1.81017294
108Generalized aminoaciduria (HP:0002909)1.79499661
109Retinal dysplasia (HP:0007973)1.78652899
110Glycosuria (HP:0003076)1.78451878
111Abnormality of urine glucose concentration (HP:0011016)1.78451878
112Progressive microcephaly (HP:0000253)1.77750790
113Poor head control (HP:0002421)1.76607859
114Nephronophthisis (HP:0000090)1.75539729
115Hypoplasia of the pons (HP:0012110)1.75314749
116Congenital stationary night blindness (HP:0007642)1.74768460
117Carpal bone hypoplasia (HP:0001498)1.74199644
118Myelodysplasia (HP:0002863)1.73067815
119Blindness (HP:0000618)1.72854536
120Hyperglycinuria (HP:0003108)1.72709451
121Multiple enchondromatosis (HP:0005701)1.72312889
122Progressive muscle weakness (HP:0003323)1.71970375
123Duodenal stenosis (HP:0100867)1.70958030
124Small intestinal stenosis (HP:0012848)1.70958030
125Congenital, generalized hypertrichosis (HP:0004540)1.70838833
126Severe visual impairment (HP:0001141)1.70567141
127Aplasia involving forearm bones (HP:0009822)1.69966668
128Absent forearm bone (HP:0003953)1.69966668
129Colon cancer (HP:0003003)1.69089762
130Cerebral edema (HP:0002181)1.68741082
131Megaloblastic anemia (HP:0001889)1.68425276
132Increased serum pyruvate (HP:0003542)1.67673221
133Hyperphosphaturia (HP:0003109)1.67652361
134Abnormality of glycolysis (HP:0004366)1.66122686
135Nausea (HP:0002018)1.66076176
136Clubbing of toes (HP:0100760)1.64922002
137Abnormality of the pons (HP:0007361)1.64646253
138Gliosis (HP:0002171)1.64401165
139Optic nerve coloboma (HP:0000588)1.63645538
140Myokymia (HP:0002411)1.63416540
141Hypoplasia of the uterus (HP:0000013)1.63252992
142Ketosis (HP:0001946)1.63060707
143Gout (HP:0001997)1.62745896
144Ketoacidosis (HP:0001993)1.58521396
145Abnormality of serine family amino acid metabolism (HP:0010894)1.57374791
146Abnormality of glycine metabolism (HP:0010895)1.57374791
147Opisthotonus (HP:0002179)1.56990807
148Vomiting (HP:0002013)1.56852055
149Severe muscular hypotonia (HP:0006829)1.56741630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.62913441
2STK164.76053831
3BUB13.92188021
4NME23.73405371
5TLK13.25945763
6EIF2AK12.83368612
7WEE12.74764876
8ZAK2.44252365
9PIM22.32552523
10IRAK32.26872816
11SRPK12.26559393
12VRK12.15356724
13PLK42.03901216
14DYRK31.87325660
15EIF2AK31.81304398
16MAP4K21.79913248
17CSNK1G31.74784562
18MKNK21.68962462
19WNK31.67776089
20EIF2AK21.61520542
21PLK11.56049474
22TESK21.54269282
23NME11.53752355
24IRAK41.53649779
25MAP2K71.53212243
26CDK71.50584199
27MKNK11.43431972
28BLK1.43076480
29LIMK11.39580789
30BCKDK1.39498991
31MAP3K111.39102362
32DYRK21.37401194
33TRIM281.36280629
34RPS6KA41.35401772
35CSNK1G21.35054035
36PBK1.33997128
37CSNK1G11.32629545
38KDR1.32499702
39NEK11.32477090
40BRAF1.25104300
41CSNK1A1L1.19647431
42TESK11.18871119
43PDK21.17753297
44TTK1.16348258
45TEC1.16279693
46ADRBK21.14020221
47TAOK21.13855926
48MAPK151.13819149
49AURKB1.13138705
50ARAF1.12240497
51PASK1.12056577
52CDC71.10598601
53TXK1.05802359
54AURKA1.05020482
55ATR1.04161587
56TAF11.00739690
57DAPK10.98873203
58GRK10.97817419
59PHKG20.96319191
60PHKG10.96319191
61ACVR1B0.93692518
62NEK20.93661345
63CDK80.92455843
64MAP3K40.92255335
65YES10.92058095
66CSNK2A10.89928283
67TSSK60.89484788
68ILK0.89465350
69BRSK20.89334295
70EPHA20.84739545
71RPS6KA50.84264573
72AKT30.84228326
73MAP2K20.83921625
74LRRK20.83271123
75CHEK20.82510791
76TNIK0.81358532
77PIM10.81116784
78IKBKB0.79576201
79STK40.78757311
80BTK0.77442023
81MAP4K10.77297557
82PLK30.74473178
83NEK90.74065040
84PIK3CG0.73841071
85IRAK10.73164693
86NLK0.71955965
87STK38L0.71421691
88PRKCI0.70302615
89DAPK30.70033490
90CDK190.69439685
91MST40.69234014
92WNK40.67853846
93ABL20.65421187
94ZAP700.65300114
95CCNB10.65227987
96CSNK2A20.65224874
97RPS6KB20.63439007
98SIK30.62857319
99MAP3K120.62084040
100MAPK130.60561808
101MAPKAPK30.60351916
102FLT30.58860069
103LYN0.57530054
104BMPR1B0.54020856
105CASK0.50570981
106PRKCG0.49815359
107INSRR0.49105451
108MAP2K60.48174858
109OXSR10.46964420
110CLK10.46945374
111NUAK10.46850851
112CHEK10.45295566
113PINK10.44803616
114CSNK1A10.44471317
115ATM0.42434495
116MAPKAPK50.41815435
117TYK20.41496199
118PKN10.40667548
119MYLK0.40305912
120IRAK20.40195711
121KIT0.40056113
122TIE10.39952758
123MAP3K80.39611762
124MUSK0.39605385
125EPHB20.37659166
126CDK20.37600010
127CDK40.36805475
128PAK10.36804967
129AKT20.36563961
130TGFBR10.36441914
131BRSK10.36277164
132GRK70.35141556
133SYK0.34803078
134MAP2K30.34601101
135BRD40.34459669
136PRKD30.34382372
137OBSCN0.33239149
138DYRK1B0.32678858
139PAK30.31082397
140MARK30.29774867
141PRKACA0.29156520
142CDK11A0.27836244
143CAMK2G0.27167988
144CDK140.27013292
145MINK10.26179923
146CAMKK20.23261612

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.86295795
2DNA replication_Homo sapiens_hsa030303.90144812
3Proteasome_Homo sapiens_hsa030503.66998679
4RNA polymerase_Homo sapiens_hsa030203.59171889
5Mismatch repair_Homo sapiens_hsa034303.43494993
6Homologous recombination_Homo sapiens_hsa034402.81557033
7Base excision repair_Homo sapiens_hsa034102.76079359
8Pyrimidine metabolism_Homo sapiens_hsa002402.70526933
9Spliceosome_Homo sapiens_hsa030402.60293306
10Protein export_Homo sapiens_hsa030602.56771640
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.51393409
12Nucleotide excision repair_Homo sapiens_hsa034202.47616062
13Fanconi anemia pathway_Homo sapiens_hsa034602.13858303
14One carbon pool by folate_Homo sapiens_hsa006702.09064224
15Oxidative phosphorylation_Homo sapiens_hsa001901.99879976
16Cardiac muscle contraction_Homo sapiens_hsa042601.96609642
17Folate biosynthesis_Homo sapiens_hsa007901.88504856
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.86142309
19Parkinsons disease_Homo sapiens_hsa050121.83908159
20RNA transport_Homo sapiens_hsa030131.79743144
21Basal transcription factors_Homo sapiens_hsa030221.75271560
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57146346
23Fatty acid elongation_Homo sapiens_hsa000621.52980600
24Huntingtons disease_Homo sapiens_hsa050161.52093771
25Sulfur relay system_Homo sapiens_hsa041221.51715149
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40389164
27Purine metabolism_Homo sapiens_hsa002301.37921402
28Cell cycle_Homo sapiens_hsa041101.35307356
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.30664267
30Non-homologous end-joining_Homo sapiens_hsa034501.29939961
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24959523
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.23752696
33RNA degradation_Homo sapiens_hsa030181.20245475
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19465323
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.09760646
36p53 signaling pathway_Homo sapiens_hsa041151.05275721
37Alzheimers disease_Homo sapiens_hsa050101.04277378
38Sulfur metabolism_Homo sapiens_hsa009201.03884021
39Pyruvate metabolism_Homo sapiens_hsa006201.02346627
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01085850
41Collecting duct acid secretion_Homo sapiens_hsa049661.00166889
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97864777
43Butanoate metabolism_Homo sapiens_hsa006500.96442322
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90002169
45Carbon metabolism_Homo sapiens_hsa012000.88646401
46Primary immunodeficiency_Homo sapiens_hsa053400.86100731
47Epstein-Barr virus infection_Homo sapiens_hsa051690.85146214
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85125846
49Pentose phosphate pathway_Homo sapiens_hsa000300.82202084
50Glutathione metabolism_Homo sapiens_hsa004800.81953943
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81888844
52Propanoate metabolism_Homo sapiens_hsa006400.81668528
53mRNA surveillance pathway_Homo sapiens_hsa030150.78579813
54Arachidonic acid metabolism_Homo sapiens_hsa005900.77846664
55Vitamin B6 metabolism_Homo sapiens_hsa007500.75995832
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73674512
57Herpes simplex infection_Homo sapiens_hsa051680.72698748
58Nitrogen metabolism_Homo sapiens_hsa009100.70477637
59Selenocompound metabolism_Homo sapiens_hsa004500.69517415
60Systemic lupus erythematosus_Homo sapiens_hsa053220.68570586
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.68146392
62Phototransduction_Homo sapiens_hsa047440.66408992
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66335030
64Metabolic pathways_Homo sapiens_hsa011000.66243110
65Other glycan degradation_Homo sapiens_hsa005110.65350397
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63786725
67Galactose metabolism_Homo sapiens_hsa000520.62485502
68Regulation of autophagy_Homo sapiens_hsa041400.61430433
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.58490911
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.52683404
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51794668
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51577239
73Allograft rejection_Homo sapiens_hsa053300.51120167
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50799018
75Arginine and proline metabolism_Homo sapiens_hsa003300.50007256
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.48819049
77Linoleic acid metabolism_Homo sapiens_hsa005910.48624956
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.46171442
79beta-Alanine metabolism_Homo sapiens_hsa004100.45979819
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45711110
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45066311
82Retinol metabolism_Homo sapiens_hsa008300.44697687
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44593985
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43623237
85N-Glycan biosynthesis_Homo sapiens_hsa005100.43194287
86Alcoholism_Homo sapiens_hsa050340.42657538
87Peroxisome_Homo sapiens_hsa041460.41305482
88Legionellosis_Homo sapiens_hsa051340.40774183
89Vibrio cholerae infection_Homo sapiens_hsa051100.40341811
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38349054
91Vitamin digestion and absorption_Homo sapiens_hsa049770.37526495
92Hematopoietic cell lineage_Homo sapiens_hsa046400.37401197
93Fructose and mannose metabolism_Homo sapiens_hsa000510.36543664
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36396781
95Measles_Homo sapiens_hsa051620.36289571
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.36203819
97Autoimmune thyroid disease_Homo sapiens_hsa053200.35415748
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33679968
99Graft-versus-host disease_Homo sapiens_hsa053320.32982840
100Chemical carcinogenesis_Homo sapiens_hsa052040.32164930
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32083265
102Asthma_Homo sapiens_hsa053100.31619567
103Synaptic vesicle cycle_Homo sapiens_hsa047210.30180319
104Antigen processing and presentation_Homo sapiens_hsa046120.29710520
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29695864
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29364712
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29140385
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28164112
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27963100
110Nicotine addiction_Homo sapiens_hsa050330.27741821
111Biosynthesis of amino acids_Homo sapiens_hsa012300.27491545
112Tyrosine metabolism_Homo sapiens_hsa003500.25372423
113Basal cell carcinoma_Homo sapiens_hsa052170.24799218
114Fatty acid metabolism_Homo sapiens_hsa012120.24614070
115Histidine metabolism_Homo sapiens_hsa003400.23987487
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23327682
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.23234850
118Apoptosis_Homo sapiens_hsa042100.22035394
119Fat digestion and absorption_Homo sapiens_hsa049750.21545499
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21211506
121Arginine biosynthesis_Homo sapiens_hsa002200.20545153
122Tryptophan metabolism_Homo sapiens_hsa003800.20372914
123Phenylalanine metabolism_Homo sapiens_hsa003600.19574259
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.17892157
125Steroid biosynthesis_Homo sapiens_hsa001000.17004290
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16863482
127Viral carcinogenesis_Homo sapiens_hsa052030.16810065
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16477408

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