TIMM21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.92251034
2DNA deamination (GO:0045006)4.38531083
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.35694224
4viral transcription (GO:0019083)4.30413802
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.25197668
6maturation of SSU-rRNA (GO:0030490)4.21910491
7translational termination (GO:0006415)4.20149186
8proteasome assembly (GO:0043248)4.02345134
9* mitochondrial respiratory chain complex assembly (GO:0033108)4.01195641
10* protein complex biogenesis (GO:0070271)4.00291442
11CENP-A containing nucleosome assembly (GO:0034080)3.97863832
12DNA strand elongation involved in DNA replication (GO:0006271)3.93292313
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.91920987
14L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.91443370
15ribosomal small subunit biogenesis (GO:0042274)3.90622603
16telomere maintenance via semi-conservative replication (GO:0032201)3.88117097
17cotranslational protein targeting to membrane (GO:0006613)3.87165535
18respiratory electron transport chain (GO:0022904)3.85368810
19electron transport chain (GO:0022900)3.81639399
20protein targeting to ER (GO:0045047)3.81147965
21translational elongation (GO:0006414)3.80928444
22DNA strand elongation (GO:0022616)3.79826922
23chromatin remodeling at centromere (GO:0031055)3.75555231
24RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.67505011
25tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.67505011
26protein localization to endoplasmic reticulum (GO:0070972)3.64178970
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.61067621
28establishment of protein localization to endoplasmic reticulum (GO:0072599)3.60101946
29establishment of integrated proviral latency (GO:0075713)3.59666355
30protein-cofactor linkage (GO:0018065)3.55156222
31telomere maintenance via recombination (GO:0000722)3.53198011
32DNA double-strand break processing (GO:0000729)3.52863696
33mitochondrial RNA metabolic process (GO:0000959)3.51105284
34peptidyl-histidine modification (GO:0018202)3.47107752
35rRNA modification (GO:0000154)3.46874164
36oxidative phosphorylation (GO:0006119)3.45536971
37DNA replication initiation (GO:0006270)3.45450679
38protein neddylation (GO:0045116)3.39101051
39purine nucleobase biosynthetic process (GO:0009113)3.37194141
40nucleobase biosynthetic process (GO:0046112)3.32923544
41translational initiation (GO:0006413)3.32696316
42ribosomal large subunit biogenesis (GO:0042273)3.32378624
43amino acid salvage (GO:0043102)3.30933845
44L-methionine salvage (GO:0071267)3.30933845
45L-methionine biosynthetic process (GO:0071265)3.30933845
46ATP synthesis coupled proton transport (GO:0015986)3.29591745
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.29591745
48water-soluble vitamin biosynthetic process (GO:0042364)3.28847082
49viral life cycle (GO:0019058)3.25146368
50DNA unwinding involved in DNA replication (GO:0006268)3.24503869
51DNA replication-independent nucleosome assembly (GO:0006336)3.22364941
52DNA replication-independent nucleosome organization (GO:0034724)3.22364941
53nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.19686365
54mitotic recombination (GO:0006312)3.17566932
55regulation of mitochondrial translation (GO:0070129)3.16213731
56* respiratory chain complex IV assembly (GO:0008535)3.16042224
57DNA damage response, detection of DNA damage (GO:0042769)3.14826041
58transcription from mitochondrial promoter (GO:0006390)3.10059426
59translation (GO:0006412)3.09086356
60IMP biosynthetic process (GO:0006188)3.08133045
61cellular protein complex disassembly (GO:0043624)3.07828400
62ribonucleoprotein complex biogenesis (GO:0022613)3.07637880
63replication fork processing (GO:0031297)3.04569316
64inner mitochondrial membrane organization (GO:0007007)3.03945267
65exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.03773158
66formation of translation preinitiation complex (GO:0001731)3.03656996
67deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.02910213
68* mitochondrial respiratory chain complex I assembly (GO:0032981)3.02477884
69* NADH dehydrogenase complex assembly (GO:0010257)3.02477884
70* mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.02477884
71negative regulation of DNA-dependent DNA replication (GO:2000104)3.01955815
72tRNA processing (GO:0008033)3.01304186
73rRNA methylation (GO:0031167)3.00229238
74transcription elongation from RNA polymerase III promoter (GO:0006385)2.98331252
75termination of RNA polymerase III transcription (GO:0006386)2.98331252
76establishment of viral latency (GO:0019043)2.96719251
77DNA catabolic process, exonucleolytic (GO:0000738)2.95591060
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.94814963
79quinone biosynthetic process (GO:1901663)2.93283760
80ubiquinone biosynthetic process (GO:0006744)2.93283760
81* protein targeting to mitochondrion (GO:0006626)2.92674004
82histone exchange (GO:0043486)2.91765854
83regulation of cellular amino acid metabolic process (GO:0006521)2.90551712
84kinetochore organization (GO:0051383)2.88159473
85L-serine metabolic process (GO:0006563)2.86560979
86IMP metabolic process (GO:0046040)2.86329880
87telomere maintenance via telomere lengthening (GO:0010833)2.86195985
88regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84226112
89regulation of mitotic spindle checkpoint (GO:1903504)2.84226112
90* cytochrome complex assembly (GO:0017004)2.83497300
91aerobic respiration (GO:0009060)2.83181871
92signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.82730449
93signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.82730449
94signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.82730449
95* establishment of protein localization to mitochondrion (GO:0072655)2.81874776
96negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.81160911
97tRNA metabolic process (GO:0006399)2.81026915
98* protein localization to mitochondrion (GO:0070585)2.80604631
99pseudouridine synthesis (GO:0001522)2.80042152
100DNA replication checkpoint (GO:0000076)2.78991144
101somatic hypermutation of immunoglobulin genes (GO:0016446)2.78418138
102somatic diversification of immune receptors via somatic mutation (GO:0002566)2.78418138
103viral mRNA export from host cell nucleus (GO:0046784)2.78237277
104maturation of 5.8S rRNA (GO:0000460)2.78232668
105DNA replication-dependent nucleosome assembly (GO:0006335)2.77686498
106DNA replication-dependent nucleosome organization (GO:0034723)2.77686498
107* cellular component biogenesis (GO:0044085)2.76585064
108intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.76200134
109signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.76200134
110rRNA processing (GO:0006364)2.75938603
111positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.72579223
112transcription-coupled nucleotide-excision repair (GO:0006283)2.72202706
113signal transduction involved in cell cycle checkpoint (GO:0072395)2.70962428
114regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70730379
115serine family amino acid biosynthetic process (GO:0009070)2.70384071
116signal transduction involved in DNA integrity checkpoint (GO:0072401)2.70355906
117signal transduction involved in DNA damage checkpoint (GO:0072422)2.70355906
118positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.68865273
119heart process (GO:0003015)2.68635019
120heart contraction (GO:0060047)2.68635019
121nucleotide-excision repair, DNA gap filling (GO:0006297)2.68230310
122ribosome biogenesis (GO:0042254)2.68207475
123nuclear-transcribed mRNA catabolic process (GO:0000956)2.67862791
124anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.67668221
125behavioral response to nicotine (GO:0035095)2.65942516
126chaperone-mediated protein transport (GO:0072321)2.65443795
127platelet dense granule organization (GO:0060155)2.64926965
128spliceosomal snRNP assembly (GO:0000387)2.64615165
129protein deneddylation (GO:0000338)2.64494085
130protein complex disassembly (GO:0043241)2.63548585
131rRNA metabolic process (GO:0016072)2.63054106
132pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.62610256
133ATP biosynthetic process (GO:0006754)2.62265934
134pteridine-containing compound biosynthetic process (GO:0042559)2.62213145
135kinetochore assembly (GO:0051382)2.61977616
136mitotic metaphase plate congression (GO:0007080)2.61523991
1377-methylguanosine mRNA capping (GO:0006370)2.61105786
138polyketide metabolic process (GO:0030638)2.60448400
139doxorubicin metabolic process (GO:0044598)2.60448400
140daunorubicin metabolic process (GO:0044597)2.60448400
141positive regulation of ligase activity (GO:0051351)2.60327876
142RNA capping (GO:0036260)2.59405927
1437-methylguanosine RNA capping (GO:0009452)2.59405927
144ubiquinone metabolic process (GO:0006743)2.58136557
145negative regulation of ligase activity (GO:0051352)2.58122179
146negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.58122179
147methionine biosynthetic process (GO:0009086)2.56467737
148ribosome assembly (GO:0042255)2.56322407
149purine nucleoside triphosphate biosynthetic process (GO:0009145)2.56208751
150cullin deneddylation (GO:0010388)2.55730327
151DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.55689838
152mRNA catabolic process (GO:0006402)2.55159508

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.21343001
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.51678815
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.07418182
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.06732001
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.77460751
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.55737005
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.55154973
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.22950765
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.91935448
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.87971330
11ZNF274_21170338_ChIP-Seq_K562_Hela2.86258981
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82979382
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.82065875
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.81300964
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.74167996
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.72542731
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66159490
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.64104882
19VDR_22108803_ChIP-Seq_LS180_Human2.50107436
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.39826059
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36822014
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32373098
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29564830
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28979452
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.27820230
26AR_21909140_ChIP-Seq_LNCAP_Human2.25576837
27VDR_23849224_ChIP-Seq_CD4+_Human2.21164463
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.20147093
29FOXM1_23109430_ChIP-Seq_U2OS_Human2.17699820
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.11783554
31XRN2_22483619_ChIP-Seq_HELA_Human2.10322333
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09432100
33FOXP3_21729870_ChIP-Seq_TREG_Human2.09393753
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.07152841
35DCP1A_22483619_ChIP-Seq_HELA_Human2.06832961
36HOXB4_20404135_ChIP-ChIP_EML_Mouse2.05927491
37RBPJ_22232070_ChIP-Seq_NCS_Mouse2.03701849
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.02791575
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.92156686
40ELK1_19687146_ChIP-ChIP_HELA_Human1.91593862
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.90952655
42FUS_26573619_Chip-Seq_HEK293_Human1.90332753
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90059055
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85210116
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84626361
46EWS_26573619_Chip-Seq_HEK293_Human1.83920823
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78339270
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76568069
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.76133674
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.75894737
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.73877376
52* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.73738876
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71187917
54GABP_19822575_ChIP-Seq_HepG2_Human1.70974841
55TTF2_22483619_ChIP-Seq_HELA_Human1.64214179
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63711876
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56803906
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55482282
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51043776
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46090677
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.45857233
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43896698
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42267239
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.42144780
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39178098
66IGF1R_20145208_ChIP-Seq_DFB_Human1.39174094
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37525304
68TAF15_26573619_Chip-Seq_HEK293_Human1.37001568
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.36055583
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35937902
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29542477
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.27804930
73P300_19829295_ChIP-Seq_ESCs_Human1.25957294
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25747660
75GBX2_23144817_ChIP-Seq_PC3_Human1.25559240
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24454351
77CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.22675593
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21238396
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19764588
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19649701
81HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.19511863
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19490960
83CIITA_25753668_ChIP-Seq_RAJI_Human1.19241454
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.18087363
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17818014
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17756607
87TP53_22573176_ChIP-Seq_HFKS_Human1.17060716
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16112891
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15971873
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14641822
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12993430
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11895339
93SOX2_16153702_ChIP-ChIP_HESCs_Human1.10801461
94NANOG_16153702_ChIP-ChIP_HESCs_Human1.10496281
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10492661
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10015806
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09000207
98MYC_18940864_ChIP-ChIP_HL60_Human1.08161928
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07595263
100MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05915015
101FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03451101
102NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03017786
103POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02615123
104TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01850289
105SCL_19346495_ChIP-Seq_HPC-7_Human1.00902765
106RXR_22158963_ChIP-Seq_LIVER_Mouse0.99345946
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97899721
108FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94839435
109SOX2_19829295_ChIP-Seq_ESCs_Human0.94472514
110NANOG_19829295_ChIP-Seq_ESCs_Human0.94472514
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94174115
112SPI1_23547873_ChIP-Seq_NB4_Human0.93572123
113KDM5A_27292631_Chip-Seq_BREAST_Human0.93308479
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92889034
115ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92808151
116ELK1_22589737_ChIP-Seq_MCF10A_Human0.92273207
117PPARA_22158963_ChIP-Seq_LIVER_Mouse0.92140896
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92116992
119E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88400366
120ER_23166858_ChIP-Seq_MCF-7_Human0.87803421
121IRF1_19129219_ChIP-ChIP_H3396_Human0.86871197
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86152620
123SOX17_20123909_ChIP-Seq_XEN_Mouse0.85991917
124EZH2_22144423_ChIP-Seq_EOC_Human0.83571738
125EZH2_27294783_Chip-Seq_NPCs_Mouse0.82866830
126CBP_20019798_ChIP-Seq_JUKART_Human0.82245223
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82245223
128FOXA1_27270436_Chip-Seq_PROSTATE_Human0.81523961
129FOXA1_25329375_ChIP-Seq_VCAP_Human0.81523961
130GATA4_21415370_ChIP-Seq_HL-1_Mouse0.81060281
131CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80207563
132RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.78316908
133GATA1_22025678_ChIP-Seq_K562_Human0.78175564
134NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.77464177
135SOX2_18555785_ChIP-Seq_MESCs_Mouse0.76022264
136GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74076880
137KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.71245912
138KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.69785194
139TBX5_21415370_ChIP-Seq_HL-1_Mouse0.69049922

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.15478677
2MP0003693_abnormal_embryo_hatching2.93255575
3MP0009697_abnormal_copulation2.79543658
4MP0003186_abnormal_redox_activity2.71641713
5MP0004957_abnormal_blastocyst_morpholog2.71323580
6MP0010094_abnormal_chromosome_stability2.69788680
7MP0003077_abnormal_cell_cycle2.48013210
8MP0002396_abnormal_hematopoietic_system2.44337450
9MP0008877_abnormal_DNA_methylation2.39563741
10MP0002102_abnormal_ear_morphology2.30655298
11MP0003136_yellow_coat_color2.18909058
12MP0005408_hypopigmentation2.16881663
13MP0008007_abnormal_cellular_replicative2.15896748
14MP0004147_increased_porphyrin_level2.14279446
15MP0000372_irregular_coat_pigmentation2.10407879
16MP0006036_abnormal_mitochondrial_physio2.10104843
17MP0002139_abnormal_hepatobiliary_system2.02446228
18MP0006292_abnormal_olfactory_placode1.99634007
19MP0008057_abnormal_DNA_replication1.99282760
20MP0008058_abnormal_DNA_repair1.95883925
21MP0006072_abnormal_retinal_apoptosis1.90768328
22MP0005085_abnormal_gallbladder_physiolo1.89845107
23MP0002736_abnormal_nociception_after1.86094925
24MP0004145_abnormal_muscle_electrophysio1.82277853
25MP0003111_abnormal_nucleus_morphology1.77105429
26MP0005365_abnormal_bile_salt1.73083517
27MP0005360_urolithiasis1.72401531
28MP0009379_abnormal_foot_pigmentation1.70869570
29MP0006054_spinal_hemorrhage1.69937528
30MP0003656_abnormal_erythrocyte_physiolo1.67453000
31MP0002638_abnormal_pupillary_reflex1.64418036
32MP0001853_heart_inflammation1.63987301
33MP0010368_abnormal_lymphatic_system1.63886293
34MP0003195_calcinosis1.58128862
35MP0001764_abnormal_homeostasis1.57936331
36MP0005253_abnormal_eye_physiology1.56436340
37MP0008932_abnormal_embryonic_tissue1.53830466
38MP0002132_abnormal_respiratory_system1.53507450
39MP0005551_abnormal_eye_electrophysiolog1.50201845
40MP0003718_maternal_effect1.50174098
41MP0008875_abnormal_xenobiotic_pharmacok1.49771716
42MP0001984_abnormal_olfaction1.49578625
43MP0004084_abnormal_cardiac_muscle1.46011111
44MP0009046_muscle_twitch1.45604796
45MP0003646_muscle_fatigue1.44083974
46MP0003567_abnormal_fetal_cardiomyocyte1.41645418
47MP0005645_abnormal_hypothalamus_physiol1.41246255
48MP0008872_abnormal_physiological_respon1.40573333
49MP0000749_muscle_degeneration1.40373773
50MP0003880_abnormal_central_pattern1.39896366
51MP0005646_abnormal_pituitary_gland1.35720740
52MP0005075_abnormal_melanosome_morpholog1.35086512
53MP0008789_abnormal_olfactory_epithelium1.34879222
54MP0001968_abnormal_touch/_nociception1.33995086
55MP0005451_abnormal_body_composition1.27776791
56MP0002160_abnormal_reproductive_system1.26619874
57MP0004142_abnormal_muscle_tone1.26162033
58MP0003763_abnormal_thymus_physiology1.25959239
59MP0005187_abnormal_penis_morphology1.25693486
60MP0002938_white_spotting1.24985353
61MP0009384_cardiac_valve_regurgitation1.20314247
62MP0010030_abnormal_orbit_morphology1.20163254
63MP0002234_abnormal_pharynx_morphology1.20085431
64MP0003011_delayed_dark_adaptation1.19357241
65MP0004215_abnormal_myocardial_fiber1.19094131
66MP0001879_abnormal_lymphatic_vessel1.19042550
67MP0008995_early_reproductive_senescence1.18166249
68MP0004808_abnormal_hematopoietic_stem1.16356013
69MP0006035_abnormal_mitochondrial_morpho1.16063397
70MP0003123_paternal_imprinting1.15855996
71MP0001485_abnormal_pinna_reflex1.13928234
72MP0000631_abnormal_neuroendocrine_gland1.13851132
73MP0003221_abnormal_cardiomyocyte_apopto1.12719676
74MP0003937_abnormal_limbs/digits/tail_de1.12108144
75MP0009745_abnormal_behavioral_response1.11983982
76MP0009785_altered_susceptibility_to1.11855038
77MP0008775_abnormal_heart_ventricle1.09223448
78MP0009333_abnormal_splenocyte_physiolog1.06381603
79MP0005397_hematopoietic_system_phenotyp1.05869308
80MP0001545_abnormal_hematopoietic_system1.05869308
81MP0004133_heterotaxia1.05398265
82MP0005332_abnormal_amino_acid1.04648321
83MP0000490_abnormal_crypts_of1.04455096
84MP0006276_abnormal_autonomic_nervous1.03695655
85MP0001986_abnormal_taste_sensitivity1.03435653
86MP0005171_absent_coat_pigmentation1.02046529
87MP0002249_abnormal_larynx_morphology1.01343370
88MP0001730_embryonic_growth_arrest1.00241906
89MP0002210_abnormal_sex_determination1.00124227
90MP0002272_abnormal_nervous_system0.99810514
91MP0001835_abnormal_antigen_presentation0.98417056
92MP0005330_cardiomyopathy0.98273016
93MP0000566_synostosis0.97591823
94MP0001929_abnormal_gametogenesis0.96631206
95MP0002735_abnormal_chemical_nociception0.96500597
96MP0005671_abnormal_response_to0.95787213
97MP0005266_abnormal_metabolism0.95374526
98MP0003890_abnormal_embryonic-extraembry0.95186864
99MP0003121_genomic_imprinting0.94534266
100MP0004885_abnormal_endolymph0.93324086
101MP0000689_abnormal_spleen_morphology0.93276783
102MP0002751_abnormal_autonomic_nervous0.93180127
103MP0002009_preneoplasia0.92647833
104MP0001486_abnormal_startle_reflex0.92117990
105MP0004036_abnormal_muscle_relaxation0.91728527
106MP0000647_abnormal_sebaceous_gland0.90798570
107MP0002095_abnormal_skin_pigmentation0.89465251
108MP0002722_abnormal_immune_system0.87941936
109MP0003786_premature_aging0.87279502
110MP0000343_altered_response_to0.85531921
111MP0000313_abnormal_cell_death0.85162285
112MP0003941_abnormal_skin_development0.84802671
113MP0002166_altered_tumor_susceptibility0.84318600
114MP0003724_increased_susceptibility_to0.84208730
115MP0005389_reproductive_system_phenotype0.83692707
116MP0005394_taste/olfaction_phenotype0.83318341
117MP0005499_abnormal_olfactory_system0.83318341
118MP0002398_abnormal_bone_marrow0.83108426
119MP0004043_abnormal_pH_regulation0.83046977
120MP0002090_abnormal_vision0.82546681
121MP0000653_abnormal_sex_gland0.82527607
122MP0002127_abnormal_cardiovascular_syste0.82037111
123MP0002163_abnormal_gland_morphology0.81300237
124MP0000516_abnormal_urinary_system0.81233727
125MP0005367_renal/urinary_system_phenotyp0.81233727
126MP0001145_abnormal_male_reproductive0.80734836
127MP0001697_abnormal_embryo_size0.80573071
128MP0005319_abnormal_enzyme/_coenzyme0.80534536
129MP0001905_abnormal_dopamine_level0.80044976
130MP0002282_abnormal_trachea_morphology0.79717159
131MP0002019_abnormal_tumor_incidence0.79408797
132MP0002837_dystrophic_cardiac_calcinosis0.79267486
133MP0001529_abnormal_vocalization0.79191374
134MP0005376_homeostasis/metabolism_phenot0.78978555
135MP0002653_abnormal_ependyma_morphology0.78678242
136MP0002734_abnormal_mechanical_nocicepti0.78250550
137MP0003698_abnormal_male_reproductive0.77547153
138MP0000350_abnormal_cell_proliferation0.77490164
139MP0002429_abnormal_blood_cell0.75722155
140MP0005391_vision/eye_phenotype0.75571164
141MP0003950_abnormal_plasma_membrane0.75364091
142MP0000685_abnormal_immune_system0.74694798
143MP0001119_abnormal_female_reproductive0.74216142
144MP0002933_joint_inflammation0.73638515
145MP0000358_abnormal_cell_content/0.73010648
146MP0004924_abnormal_behavior0.71906951
147MP0005386_behavior/neurological_phenoty0.71906951
148MP0003279_aneurysm0.71734173
149MP0002067_abnormal_sensory_capabilities0.71190451
150MP0009763_increased_sensitivity_to0.70803864
151MP0003755_abnormal_palate_morphology0.70461803
152MP0005084_abnormal_gallbladder_morpholo0.70105538
153MP0001293_anophthalmia0.69667429
154MP0001544_abnormal_cardiovascular_syste0.69604632
155MP0005385_cardiovascular_system_phenoty0.69604632
156MP0000598_abnormal_liver_morphology0.69300842
157MP0000049_abnormal_middle_ear0.68502017
158MP0010630_abnormal_cardiac_muscle0.66140621
159MP0003943_abnormal_hepatobiliary_system0.65874201
160MP0003137_abnormal_impulse_conducting0.65798398
161MP0002080_prenatal_lethality0.64046036
162MP0002972_abnormal_cardiac_muscle0.63877705
163MP0001915_intracranial_hemorrhage0.63816638
164MP0001666_abnormal_nutrient_absorption0.63168588
165MP0001672_abnormal_embryogenesis/_devel0.62478987

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.34627058
2Abnormal number of erythroid precursors (HP:0012131)4.15205879
3Hepatic necrosis (HP:0002605)3.98665048
4Acute necrotizing encephalopathy (HP:0006965)3.98289492
5Acute encephalopathy (HP:0006846)3.83495389
6Abnormal mitochondria in muscle tissue (HP:0008316)3.79099333
7Hepatocellular necrosis (HP:0001404)3.75079651
8Increased CSF lactate (HP:0002490)3.57642810
9Mitochondrial inheritance (HP:0001427)3.56694447
10Abnormality of the heme biosynthetic pathway (HP:0010472)3.38561120
11Increased serum pyruvate (HP:0003542)3.32842103
12Abnormality of glycolysis (HP:0004366)3.32842103
13Reticulocytopenia (HP:0001896)3.29984161
14Lipid accumulation in hepatocytes (HP:0006561)3.27301381
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.18046743
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.18046743
17Aplastic anemia (HP:0001915)3.13007698
18Increased serum lactate (HP:0002151)3.12093034
19Cerebral edema (HP:0002181)3.11477299
20Progressive macrocephaly (HP:0004481)3.08903451
21Increased hepatocellular lipid droplets (HP:0006565)3.06017349
22Birth length less than 3rd percentile (HP:0003561)2.91612075
23Pancreatic cysts (HP:0001737)2.90051142
24Abnormality of fatty-acid metabolism (HP:0004359)2.88952253
25Respiratory difficulties (HP:0002880)2.84540068
26Lactic acidosis (HP:0003128)2.84237960
27Abnormality of the labia minora (HP:0012880)2.83101248
283-Methylglutaconic aciduria (HP:0003535)2.82884860
29Generalized aminoaciduria (HP:0002909)2.77482567
30Renal Fanconi syndrome (HP:0001994)2.76571728
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.74916855
32True hermaphroditism (HP:0010459)2.67409860
33Increased muscle lipid content (HP:0009058)2.65672026
34Abnormality of midbrain morphology (HP:0002418)2.65129678
35Molar tooth sign on MRI (HP:0002419)2.65129678
36Macrocytic anemia (HP:0001972)2.64896936
37Pancreatic fibrosis (HP:0100732)2.64418857
38Exercise intolerance (HP:0003546)2.63939798
39Dicarboxylic aciduria (HP:0003215)2.62776593
40Abnormality of dicarboxylic acid metabolism (HP:0010995)2.62776593
41Exertional dyspnea (HP:0002875)2.60006584
42Methylmalonic acidemia (HP:0002912)2.59532358
43Increased intramyocellular lipid droplets (HP:0012240)2.59186237
44Type I transferrin isoform profile (HP:0003642)2.59007743
45Thrombocytosis (HP:0001894)2.58105621
46Oral leukoplakia (HP:0002745)2.54561938
47Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.52198762
48Meckel diverticulum (HP:0002245)2.51579111
49Medial flaring of the eyebrow (HP:0010747)2.46329114
50Abnormality of the ileum (HP:0001549)2.44346609
51Chromosomal breakage induced by crosslinking agents (HP:0003221)2.43714366
52Hypobetalipoproteinemia (HP:0003563)2.43156728
53Hyperammonemia (HP:0001987)2.39761367
54Optic disc pallor (HP:0000543)2.38154805
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.35514793
56Reduced antithrombin III activity (HP:0001976)2.33699719
57Microretrognathia (HP:0000308)2.33121807
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.32304931
59Lethargy (HP:0001254)2.32269948
60Abnormality of urine glucose concentration (HP:0011016)2.31989900
61Glycosuria (HP:0003076)2.31989900
62Respiratory failure (HP:0002878)2.30791234
63Chromsome breakage (HP:0040012)2.29671902
64Methylmalonic aciduria (HP:0012120)2.28682943
65IgM deficiency (HP:0002850)2.26390626
66Rhabdomyolysis (HP:0003201)2.25033181
67Nausea (HP:0002018)2.23955266
68Hyperbilirubinemia (HP:0002904)2.21041383
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19800414
70Abnormality of alanine metabolism (HP:0010916)2.19800414
71Hyperalaninemia (HP:0003348)2.19800414
72Renal cortical cysts (HP:0000803)2.18621609
73Hyperglycinemia (HP:0002154)2.15068418
74Congenital stationary night blindness (HP:0007642)2.14760637
7511 pairs of ribs (HP:0000878)2.14648460
76Intrahepatic cholestasis (HP:0001406)2.14061535
77Nephronophthisis (HP:0000090)2.13912243
78Congenital primary aphakia (HP:0007707)2.13307816
79Gait imbalance (HP:0002141)2.11880570
80Pallor (HP:0000980)2.11687204
81Prolonged partial thromboplastin time (HP:0003645)2.09874885
82Delayed CNS myelination (HP:0002188)2.09168042
83Nephrogenic diabetes insipidus (HP:0009806)2.08453917
84Abnormal lung lobation (HP:0002101)2.08415461
85Abnormality of aromatic amino acid family metabolism (HP:0004338)2.08257479
86Type II lissencephaly (HP:0007260)2.07514939
87Irregular epiphyses (HP:0010582)2.07482269
88Pancytopenia (HP:0001876)2.02818091
89Leukodystrophy (HP:0002415)2.02654172
90Cerebral hypomyelination (HP:0006808)2.02562084
91Colon cancer (HP:0003003)2.02221235
92Abnormality of the preputium (HP:0100587)2.01434226
93Selective tooth agenesis (HP:0001592)2.01184585
94Hypoglycemic coma (HP:0001325)2.01026709
95Abnormality of chromosome stability (HP:0003220)2.00342651
96Rough bone trabeculation (HP:0100670)1.99103126
97CNS demyelination (HP:0007305)1.98081891
98Pendular nystagmus (HP:0012043)1.97097577
99Supernumerary spleens (HP:0009799)1.96107309
100Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95111238
101Abnormal protein N-linked glycosylation (HP:0012347)1.95111238
102Abnormal protein glycosylation (HP:0012346)1.95111238
103Abnormal glycosylation (HP:0012345)1.95111238
104Inability to walk (HP:0002540)1.89307560
105Abnormality of serum amino acid levels (HP:0003112)1.87462651
106Congenital, generalized hypertrichosis (HP:0004540)1.87318986
107Sclerocornea (HP:0000647)1.86578462
108Patchy hypopigmentation of hair (HP:0011365)1.84704785
109Abnormality of methionine metabolism (HP:0010901)1.84697790
110Breast hypoplasia (HP:0003187)1.84571017
111Abnormality of monocarboxylic acid metabolism (HP:0010996)1.84313583
112Myoglobinuria (HP:0002913)1.83236316
113Abnormality of glycine metabolism (HP:0010895)1.82112563
114Abnormality of serine family amino acid metabolism (HP:0010894)1.82112563
115Patellar aplasia (HP:0006443)1.81413510
116Diastasis recti (HP:0001540)1.78975673
117Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77560757
118Abnormality of the renal cortex (HP:0011035)1.76516962
119Carpal bone hypoplasia (HP:0001498)1.76497664
120Aplasia/Hypoplasia of the patella (HP:0006498)1.76239258
121Hyperglycinuria (HP:0003108)1.75820562
122Premature graying of hair (HP:0002216)1.75373489
123Sloping forehead (HP:0000340)1.74743559
124Steatorrhea (HP:0002570)1.74201847
125Small intestinal stenosis (HP:0012848)1.72893436
126Duodenal stenosis (HP:0100867)1.72893436
127Proximal tubulopathy (HP:0000114)1.72569357
128Abnormality of the pons (HP:0007361)1.70993215
129Abnormality of pyrimidine metabolism (HP:0004353)1.70948469
130White forelock (HP:0002211)1.69497364
131Progressive microcephaly (HP:0000253)1.68888426
132Amniotic constriction ring (HP:0009775)1.68051759
133Abnormality of placental membranes (HP:0011409)1.68051759
134Broad-based gait (HP:0002136)1.68039660
135Genital tract atresia (HP:0001827)1.67898520
136X-linked dominant inheritance (HP:0001423)1.67782817
137Exercise-induced muscle cramps (HP:0003710)1.66285322
138Abnormality of the renal medulla (HP:0100957)1.66241409
139Hypoplasia of the pons (HP:0012110)1.65899698
140Abnormality of the axillary hair (HP:0100134)1.65524236
141Abnormality of secondary sexual hair (HP:0009888)1.65524236
142Multiple enchondromatosis (HP:0005701)1.65332999
143Abnormality of renal resorption (HP:0011038)1.64867914
144Vaginal atresia (HP:0000148)1.64794484
145Type 2 muscle fiber atrophy (HP:0003554)1.64629876
146Aplasia/Hypoplasia of the tongue (HP:0010295)1.64609734
147Degeneration of anterior horn cells (HP:0002398)1.63798919
148Abnormality of the anterior horn cell (HP:0006802)1.63798919
149Metabolic acidosis (HP:0001942)1.63619981

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.56879477
2BCKDK3.36826291
3BUB13.29550061
4EIF2AK32.83754661
5WEE12.82838450
6VRK22.62096514
7NME22.61668617
8VRK12.57058286
9CDC72.46517858
10BMPR1B2.46167426
11STK162.35363970
12BRSK22.21075947
13WNK32.13314476
14MUSK1.95066616
15FLT31.90974698
16KDR1.88313076
17MYLK1.88221578
18OBSCN1.87064624
19MKNK11.84731833
20MAP4K21.84328189
21FRK1.79839603
22TRIM281.79837504
23SRPK11.74940152
24MST41.69163467
25PBK1.61401059
26CASK1.60137611
27TESK21.57662015
28PASK1.55849171
29PLK41.55533696
30PDK21.55194523
31RPS6KB21.41560384
32CDK81.38357249
33TEC1.36282171
34YES11.36107362
35GRK11.35548513
36INSRR1.29730459
37EIF2AK21.25068530
38WNK41.21453717
39DYRK31.20371995
40BTK1.17506081
41TGFBR11.16864684
42AURKB1.15468265
43STK101.14546860
44CDK71.13548820
45RPS6KA41.12165289
46PLK21.12040326
47ZAK1.09687300
48MAP3K41.08604056
49BRSK11.07059398
50PLK31.06699959
51NUAK11.06641111
52PINK11.05094214
53IRAK41.04352267
54PLK11.03819742
55MKNK21.02685404
56ATR1.01473752
57KIT1.01088759
58TYK21.00166705
59PHKG20.95617179
60PHKG10.95617179
61ERBB30.94886781
62DYRK20.94875483
63ACVR1B0.94660083
64CCNB10.93860714
65LIMK10.93396867
66MAP4K10.92557181
67CSNK1G20.91951896
68STK390.90584799
69OXSR10.88914781
70PNCK0.88234915
71MAPK130.86454817
72TTK0.85620755
73TSSK60.85394251
74PAK30.81687794
75LRRK20.81397273
76CSF1R0.80991428
77ILK0.77927639
78MAP2K70.77029347
79PRKCG0.76827367
80CSNK2A10.76576614
81BCR0.76231787
82ABL20.74891272
83STK40.74877350
84CSNK1G30.74093974
85TNIK0.70697664
86TIE10.69989349
87TXK0.68825985
88MAP3K30.68815663
89TAF10.68493267
90MARK10.67608019
91TRPM70.67554722
92MAP3K80.66425988
93AURKA0.65087334
94PRKCE0.61888734
95STK240.61133578
96CSNK2A20.58928681
97MAPK110.58886752
98CHEK20.58701602
99TLK10.58474275
100PIK3CG0.57838658
101NEK10.55134475
102MAP2K30.54747639
103PIK3CA0.52360064
104PAK40.52350466
105MINK10.51768593
106PIM20.51726491
107ZAP700.51449313
108ADRBK10.50261745
109CAMKK20.50136302
110LYN0.48988898
111CAMK2A0.48140777
112RPS6KA50.48115740
113TGFBR20.47317517
114CSNK1G10.47241583
115CDK40.47221546
116ATM0.44273803
117MAPKAPK50.43740408
118CHEK10.43397346
119NLK0.43382566
120PIM10.42807336
121PRKCI0.42655805
122CSNK1A10.41758420
123CSNK1E0.41686784
124CDK30.41380715
125STK38L0.41286095
126NME10.40725898
127NEK20.40474552
128PDK40.40384680
129PDK30.40384680
130MAPKAPK20.38988546
131ADRBK20.38779647
132IRAK10.36804293
133ERBB40.36203022
134MAP3K110.36116854
135STK30.35383971
136NEK60.35350846
137CLK10.35337081
138PRKACA0.33682670
139IKBKE0.33670433
140CSNK1A1L0.33154669
141NEK90.32778033
142CDK10.32340027
143EPHA40.32087063
144CAMK2D0.29944724
145PKN10.28589374

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.55070227
2DNA replication_Homo sapiens_hsa030303.51304472
3Proteasome_Homo sapiens_hsa030502.79809629
4Mismatch repair_Homo sapiens_hsa034302.73815719
5RNA polymerase_Homo sapiens_hsa030202.58898690
6Protein export_Homo sapiens_hsa030602.16882038
7Pyrimidine metabolism_Homo sapiens_hsa002402.12567872
8Base excision repair_Homo sapiens_hsa034102.04816789
9Homologous recombination_Homo sapiens_hsa034402.04447744
10Spliceosome_Homo sapiens_hsa030402.01042922
11Nucleotide excision repair_Homo sapiens_hsa034201.98630749
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.97500033
13Non-homologous end-joining_Homo sapiens_hsa034501.96025547
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.94295233
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89406221
16One carbon pool by folate_Homo sapiens_hsa006701.78611678
17Propanoate metabolism_Homo sapiens_hsa006401.70510860
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.68606500
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.61804111
20Parkinsons disease_Homo sapiens_hsa050121.60855277
21Fatty acid elongation_Homo sapiens_hsa000621.60499916
22Basal transcription factors_Homo sapiens_hsa030221.60155179
23Oxidative phosphorylation_Homo sapiens_hsa001901.53828259
24RNA transport_Homo sapiens_hsa030131.52598816
25RNA degradation_Homo sapiens_hsa030181.52359419
26Fatty acid degradation_Homo sapiens_hsa000711.52300915
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50867250
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46414497
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45384715
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43373081
31Cell cycle_Homo sapiens_hsa041101.42814247
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.42717254
33Folate biosynthesis_Homo sapiens_hsa007901.41023494
34Peroxisome_Homo sapiens_hsa041461.35826602
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.33839053
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.30583817
37Pyruvate metabolism_Homo sapiens_hsa006201.28182213
38Carbon metabolism_Homo sapiens_hsa012001.28062232
39Glutathione metabolism_Homo sapiens_hsa004801.27179005
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25864545
41Biosynthesis of amino acids_Homo sapiens_hsa012301.22613832
42Huntingtons disease_Homo sapiens_hsa050161.20417643
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16598172
44Purine metabolism_Homo sapiens_hsa002301.14672703
45Selenocompound metabolism_Homo sapiens_hsa004501.11987406
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08390992
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07936668
48Nitrogen metabolism_Homo sapiens_hsa009101.07696009
49Phototransduction_Homo sapiens_hsa047441.06029779
50Retinol metabolism_Homo sapiens_hsa008301.05349685
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04753135
52Chemical carcinogenesis_Homo sapiens_hsa052041.04393963
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04093117
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01261381
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98697095
56Fanconi anemia pathway_Homo sapiens_hsa034600.97926026
57Fatty acid metabolism_Homo sapiens_hsa012120.95127306
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94671784
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94223840
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92781702
61Sulfur relay system_Homo sapiens_hsa041220.91769105
62Pentose phosphate pathway_Homo sapiens_hsa000300.88202978
63beta-Alanine metabolism_Homo sapiens_hsa004100.85717030
64Alzheimers disease_Homo sapiens_hsa050100.85159495
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84511255
66Tryptophan metabolism_Homo sapiens_hsa003800.80967774
67Arginine and proline metabolism_Homo sapiens_hsa003300.80782382
68Nicotine addiction_Homo sapiens_hsa050330.80061043
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78370934
70Metabolic pathways_Homo sapiens_hsa011000.76326975
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73297117
72Complement and coagulation cascades_Homo sapiens_hsa046100.71675403
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.70970125
74Collecting duct acid secretion_Homo sapiens_hsa049660.69840581
75p53 signaling pathway_Homo sapiens_hsa041150.68900781
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.68455266
77Tyrosine metabolism_Homo sapiens_hsa003500.67600588
78Arachidonic acid metabolism_Homo sapiens_hsa005900.67565540
79Histidine metabolism_Homo sapiens_hsa003400.67554917
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.66708319
81Regulation of autophagy_Homo sapiens_hsa041400.65353617
82Sulfur metabolism_Homo sapiens_hsa009200.64683499
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64629754
84Phenylalanine metabolism_Homo sapiens_hsa003600.61885665
85Butanoate metabolism_Homo sapiens_hsa006500.61190732
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60920201
87Oocyte meiosis_Homo sapiens_hsa041140.57706162
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56919327
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54342093
90Primary immunodeficiency_Homo sapiens_hsa053400.53018178
91Starch and sucrose metabolism_Homo sapiens_hsa005000.51543816
92Vitamin B6 metabolism_Homo sapiens_hsa007500.50810343
93Steroid biosynthesis_Homo sapiens_hsa001000.50326613
94Herpes simplex infection_Homo sapiens_hsa051680.48408811
95Caffeine metabolism_Homo sapiens_hsa002320.48181703
96Systemic lupus erythematosus_Homo sapiens_hsa053220.47873709
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45517235
98Linoleic acid metabolism_Homo sapiens_hsa005910.45419933
99Taste transduction_Homo sapiens_hsa047420.44269653
100Epstein-Barr virus infection_Homo sapiens_hsa051690.40863466
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40490112
102N-Glycan biosynthesis_Homo sapiens_hsa005100.39460173
103Ether lipid metabolism_Homo sapiens_hsa005650.38184160
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38053638
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37457422
106Olfactory transduction_Homo sapiens_hsa047400.37410291
107PPAR signaling pathway_Homo sapiens_hsa033200.37296207
108GABAergic synapse_Homo sapiens_hsa047270.35571228
109Cardiac muscle contraction_Homo sapiens_hsa042600.35019329
110Vitamin digestion and absorption_Homo sapiens_hsa049770.34474359
111Antigen processing and presentation_Homo sapiens_hsa046120.33516167
112mRNA surveillance pathway_Homo sapiens_hsa030150.33261013
113Galactose metabolism_Homo sapiens_hsa000520.33076762
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31570798
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.26697020
116Arginine biosynthesis_Homo sapiens_hsa002200.26459091
117Morphine addiction_Homo sapiens_hsa050320.25799452
118Circadian rhythm_Homo sapiens_hsa047100.25694366
119Legionellosis_Homo sapiens_hsa051340.24328178
120Fructose and mannose metabolism_Homo sapiens_hsa000510.23642995

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