TIMM44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a peripheral membrane protein associated with the mitochondrial inner membrane translocase, which functions in the import of proteins across the mitochondrial inner membrane and into the mitochondrial matrix. The encoded protein mediates binding of mitochondrial heat shock protein 70 to the translocase of inner mitochondrial membrane 23 (TIM23) complex. Expression of this gene is upregulated in kidney in a mouse model of diabetes. A mutation in this gene is associated with familial oncocytic thyroid carcinoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)4.87998137
2nucleobase biosynthetic process (GO:0046112)4.79917872
3tricarboxylic acid cycle (GO:0006099)4.49557753
4DNA deamination (GO:0045006)4.39142769
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.38869342
6chaperone-mediated protein transport (GO:0072321)4.23467152
7oxidative phosphorylation (GO:0006119)4.22278969
8ribosomal small subunit assembly (GO:0000028)4.18974867
9DNA strand elongation involved in DNA replication (GO:0006271)4.14738959
10maturation of SSU-rRNA (GO:0030490)4.08365134
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.98289588
12telomere maintenance via semi-conservative replication (GO:0032201)3.92948909
13cotranslational protein targeting to membrane (GO:0006613)3.92223819
14DNA strand elongation (GO:0022616)3.90974068
15protein targeting to ER (GO:0045047)3.89332519
16ATP synthesis coupled proton transport (GO:0015986)3.88557621
17energy coupled proton transport, down electrochemical gradient (GO:0015985)3.88557621
18DNA unwinding involved in DNA replication (GO:0006268)3.86263564
19IMP biosynthetic process (GO:0006188)3.86238700
20NADH metabolic process (GO:0006734)3.85806328
21DNA replication initiation (GO:0006270)3.85120753
22regulation of mitochondrial translation (GO:0070129)3.84210963
23viral life cycle (GO:0019058)3.80175875
24establishment of protein localization to endoplasmic reticulum (GO:0072599)3.73154241
25formation of translation preinitiation complex (GO:0001731)3.69270307
26cellular protein complex disassembly (GO:0043624)3.67028022
27folic acid metabolic process (GO:0046655)3.63770568
28protein localization to endoplasmic reticulum (GO:0070972)3.62767269
29regulation of translational fidelity (GO:0006450)3.61559973
30protein localization to kinetochore (GO:0034501)3.55801345
31IMP metabolic process (GO:0046040)3.52055240
32folic acid-containing compound biosynthetic process (GO:0009396)3.50203863
33pseudouridine synthesis (GO:0001522)3.48059320
34protein complex disassembly (GO:0043241)3.46122357
35mitotic metaphase plate congression (GO:0007080)3.44116254
36telomere maintenance via recombination (GO:0000722)3.43118353
37ribosome biogenesis (GO:0042254)3.42805054
38translational termination (GO:0006415)3.41739893
39glycine metabolic process (GO:0006544)3.41123703
40ribosome assembly (GO:0042255)3.40112857
41viral transcription (GO:0019083)3.39650783
42proteasome assembly (GO:0043248)3.37067345
43ribonucleoprotein complex biogenesis (GO:0022613)3.33964186
44regulation of sister chromatid cohesion (GO:0007063)3.33611094
45DNA replication checkpoint (GO:0000076)3.33607770
46macromolecular complex disassembly (GO:0032984)3.33231258
47nucleotide-excision repair, DNA gap filling (GO:0006297)3.32718313
48ribosomal small subunit biogenesis (GO:0042274)3.31654176
49quinone biosynthetic process (GO:1901663)3.30349192
50ubiquinone biosynthetic process (GO:0006744)3.30349192
51protein complex biogenesis (GO:0070271)3.29503867
52heterochromatin organization (GO:0070828)3.29494964
53ribosomal large subunit biogenesis (GO:0042273)3.29098567
54translational elongation (GO:0006414)3.22558721
55mitotic recombination (GO:0006312)3.21259902
562-oxoglutarate metabolic process (GO:0006103)3.20580286
57DNA-dependent DNA replication (GO:0006261)3.16351820
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.13069795
59respiratory electron transport chain (GO:0022904)3.11989643
60* establishment of protein localization to mitochondrion (GO:0072655)3.11200230
61protein localization to chromosome, centromeric region (GO:0071459)3.10670936
62* protein targeting to mitochondrion (GO:0006626)3.07042627
63telomere maintenance via telomere lengthening (GO:0010833)3.06868830
64positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.06173872
65maturation of 5.8S rRNA (GO:0000460)3.04803296
66electron transport chain (GO:0022900)3.03436005
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.03136902
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.02268712
69L-serine metabolic process (GO:0006563)3.01554309
70translational initiation (GO:0006413)2.99414040
71mitochondrial DNA replication (GO:0006264)2.98972570
72mitochondrial RNA metabolic process (GO:0000959)2.98752777
73cellular component biogenesis (GO:0044085)2.97288725
74chaperone-mediated protein complex assembly (GO:0051131)2.94336415
75metaphase plate congression (GO:0051310)2.93303316
76spliceosomal snRNP assembly (GO:0000387)2.92966390
77lysine catabolic process (GO:0006554)2.92657468
78lysine metabolic process (GO:0006553)2.92657468
79peptidyl-arginine omega-N-methylation (GO:0035247)2.92313992
80rRNA processing (GO:0006364)2.91498474
81histone arginine methylation (GO:0034969)2.91009263
82chromatin assembly (GO:0031497)2.90616297
83viral mRNA export from host cell nucleus (GO:0046784)2.90463999
84ubiquinone metabolic process (GO:0006743)2.90341321
85serine family amino acid biosynthetic process (GO:0009070)2.90231879
86nuclear-transcribed mRNA catabolic process (GO:0000956)2.89963471
87mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89532605
88regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.88909055
89establishment of protein localization to mitochondrial membrane (GO:0090151)2.87956647
90establishment of integrated proviral latency (GO:0075713)2.87689685
91* protein localization to mitochondrion (GO:0070585)2.87027027
92pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.86902338
93mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86389074
94mitochondrial respiratory chain complex I assembly (GO:0032981)2.86389074
95NADH dehydrogenase complex assembly (GO:0010257)2.86389074
96negative regulation of ligase activity (GO:0051352)2.85301601
97negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.85301601
98tRNA aminoacylation for protein translation (GO:0006418)2.81784611
99oxaloacetate metabolic process (GO:0006107)2.79609089
100pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.79431584
101mRNA catabolic process (GO:0006402)2.79290560
102rRNA metabolic process (GO:0016072)2.78950838
103protein targeting to membrane (GO:0006612)2.78847249
104mitotic chromosome condensation (GO:0007076)2.78335474
105methionine metabolic process (GO:0006555)2.78175748
106cell proliferation in forebrain (GO:0021846)2.77807704
107mitochondrial respiratory chain complex assembly (GO:0033108)2.77433589
108UTP biosynthetic process (GO:0006228)2.76485358
109amino acid activation (GO:0043038)2.75544678
110tRNA aminoacylation (GO:0043039)2.75544678
111mitochondrial DNA metabolic process (GO:0032042)2.75132198
112transcription from mitochondrial promoter (GO:0006390)2.74817110
113CENP-A containing nucleosome assembly (GO:0034080)2.73436165
114nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.72475958
115GMP metabolic process (GO:0046037)2.72226622
116methionine biosynthetic process (GO:0009086)2.72211128
117metallo-sulfur cluster assembly (GO:0031163)2.72073762
118iron-sulfur cluster assembly (GO:0016226)2.72073762
119L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.71559266
120transcription-coupled nucleotide-excision repair (GO:0006283)2.70341009
121ncRNA processing (GO:0034470)2.69556646
122negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.69488359
123base-excision repair, AP site formation (GO:0006285)2.69311586
124positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.69108281
125chromatin remodeling at centromere (GO:0031055)2.69083706
126RNA catabolic process (GO:0006401)2.68171865
127mitotic nuclear envelope disassembly (GO:0007077)2.67926938
128translation (GO:0006412)2.67594068
129aspartate family amino acid biosynthetic process (GO:0009067)2.66774639
130termination of RNA polymerase III transcription (GO:0006386)2.66391380
131transcription elongation from RNA polymerase III promoter (GO:0006385)2.66391380
132pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.66229893
133purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.65895320
134purine nucleoside monophosphate biosynthetic process (GO:0009127)2.65895320
135pteridine-containing compound biosynthetic process (GO:0042559)2.65030556
136regulation of acyl-CoA biosynthetic process (GO:0050812)2.64946582
137regulation of cofactor metabolic process (GO:0051193)2.64307467
138regulation of coenzyme metabolic process (GO:0051196)2.64307467
139L-methionine biosynthetic process (GO:0071265)2.64138674
140water-soluble vitamin biosynthetic process (GO:0042364)2.63249284
141GTP biosynthetic process (GO:0006183)2.61830351
142inner mitochondrial membrane organization (GO:0007007)2.61686038
143DNA damage response, detection of DNA damage (GO:0042769)2.60848306
144UTP metabolic process (GO:0046051)2.60207461
145ncRNA metabolic process (GO:0034660)2.59287517
146tRNA metabolic process (GO:0006399)2.58038516
147intracellular protein transmembrane import (GO:0044743)2.57324512
148chromatin assembly or disassembly (GO:0006333)2.56975530
149CTP metabolic process (GO:0046036)2.55281920
150CTP biosynthetic process (GO:0006241)2.55281920

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.39382328
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.51902865
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.35849787
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.27688427
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.39978424
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.38351504
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.34560925
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.29440371
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.08370286
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.07960078
11* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91213284
12* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84628032
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84513722
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.83425480
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.82972576
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.80367002
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.72825562
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.56251389
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.53751041
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45841559
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.45250372
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37274062
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.33483408
24* XRN2_22483619_ChIP-Seq_HELA_Human2.33347080
25VDR_23849224_ChIP-Seq_CD4+_Human2.30133033
26AR_21909140_ChIP-Seq_LNCAP_Human2.27467799
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.26263839
28DCP1A_22483619_ChIP-Seq_HELA_Human2.15000833
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14464140
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14444940
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.11305853
32* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11064565
33FOXP3_21729870_ChIP-Seq_TREG_Human2.10467974
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.06823084
35* SRF_21415370_ChIP-Seq_HL-1_Mouse2.05787684
36GABP_19822575_ChIP-Seq_HepG2_Human1.96884117
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.96542969
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91650169
39* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81113031
40* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76165073
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74985723
42TTF2_22483619_ChIP-Seq_HELA_Human1.74550851
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72354050
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70784313
45CIITA_25753668_ChIP-Seq_RAJI_Human1.70268216
46* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68622116
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.67805274
48* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67357702
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65758379
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65744313
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61318166
52* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53045935
53BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.50590974
54EZH2_22144423_ChIP-Seq_EOC_Human1.49840714
55KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.48906950
56* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.46312794
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46155771
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45319557
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43843620
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43104074
61KDM5A_27292631_Chip-Seq_BREAST_Human1.42936877
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40487689
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39912285
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39546361
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37634581
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36094741
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.34686068
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33353661
69MYC_22102868_ChIP-Seq_BL_Human1.32753608
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32403470
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30505273
72* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22738827
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21287499
74ELK1_19687146_ChIP-ChIP_HELA_Human1.20732332
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20215390
76* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.18297257
77P68_20966046_ChIP-Seq_HELA_Human1.16445760
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16174706
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12009182
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10858105
81* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10526463
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10520440
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09653698
84MYC_18940864_ChIP-ChIP_HL60_Human1.07216241
85CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06439340
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05275070
87* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05172088
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03036817
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01340602
90PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01269260
91* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99483045
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98417995
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98096931
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97943341
95ZNF263_19887448_ChIP-Seq_K562_Human0.97917374
96CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97589540
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.96659915
98PHF8_20622854_ChIP-Seq_HELA_Human0.93679739
99IRF1_19129219_ChIP-ChIP_H3396_Human0.93386798
100* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93117059
101CTCF_27219007_Chip-Seq_Bcells_Human0.92951581
102SOX2_16153702_ChIP-ChIP_HESCs_Human0.92431748
103* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92387641
104YY1_22570637_ChIP-Seq_MALME-3M_Human0.91947725
105TP63_19390658_ChIP-ChIP_HaCaT_Human0.91287297
106VDR_21846776_ChIP-Seq_THP-1_Human0.90801975
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89823334
108RXR_22158963_ChIP-Seq_LIVER_Mouse0.89711794
109CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.89313987
110RARA_24833708_ChIP-Seq_LIVER_Mouse0.88531068
111NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88159243
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88086324
113ERG_21242973_ChIP-ChIP_JURKAT_Human0.87487768
114SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87246643
115GATA1_26923725_Chip-Seq_HPCs_Mouse0.87166305
116SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87033879
117* TFEB_21752829_ChIP-Seq_HELA_Human0.86720161
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86398311
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85743829
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83203272
121* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82691733
122SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.81851925
123OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81195300
124GATA4_21415370_ChIP-Seq_HL-1_Mouse0.80323490
125NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.79914489
126ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79371560
127EGR1_19374776_ChIP-ChIP_THP-1_Human0.78356283
128* FOXP1_21924763_ChIP-Seq_HESCs_Human0.77036760
129ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.76841912

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.96787602
2MP0003693_abnormal_embryo_hatching3.77590285
3MP0003806_abnormal_nucleotide_metabolis3.72352240
4MP0003111_abnormal_nucleus_morphology3.35459524
5MP0006292_abnormal_olfactory_placode3.34399779
6MP0004957_abnormal_blastocyst_morpholog3.26435359
7MP0010094_abnormal_chromosome_stability3.13848163
8MP0009379_abnormal_foot_pigmentation3.10566385
9MP0006036_abnormal_mitochondrial_physio3.09327031
10MP0002837_dystrophic_cardiac_calcinosis3.02649702
11MP0004084_abnormal_cardiac_muscle2.85283729
12MP0003077_abnormal_cell_cycle2.67070772
13MP0004215_abnormal_myocardial_fiber2.57271613
14MP0006035_abnormal_mitochondrial_morpho2.52635300
15MP0005330_cardiomyopathy2.51868236
16MP0000751_myopathy2.46411932
17MP0003567_abnormal_fetal_cardiomyocyte2.32399607
18MP0000749_muscle_degeneration2.30888433
19MP0005360_urolithiasis2.29972051
20MP0004036_abnormal_muscle_relaxation2.29544049
21MP0010030_abnormal_orbit_morphology2.22491048
22MP0002139_abnormal_hepatobiliary_system2.13989890
23MP0001293_anophthalmia2.08777229
24MP0003221_abnormal_cardiomyocyte_apopto2.00492729
25MP0005085_abnormal_gallbladder_physiolo2.00081949
26MP0004130_abnormal_muscle_cell1.96643216
27MP0008057_abnormal_DNA_replication1.91080046
28MP0005670_abnormal_white_adipose1.89925820
29MP0002160_abnormal_reproductive_system1.86107769
30MP0001730_embryonic_growth_arrest1.84775243
31MP0008775_abnormal_heart_ventricle1.82317402
32MP0008058_abnormal_DNA_repair1.78511217
33MP0002269_muscular_atrophy1.78386394
34MP0003718_maternal_effect1.69977722
35MP0005365_abnormal_bile_salt1.69733123
36MP0003136_yellow_coat_color1.68639382
37MP0002396_abnormal_hematopoietic_system1.66021362
38MP0004087_abnormal_muscle_fiber1.65190410
39MP0008932_abnormal_embryonic_tissue1.64637512
40MP0009840_abnormal_foam_cell1.62264276
41MP0000750_abnormal_muscle_regeneration1.61278462
42MP0002163_abnormal_gland_morphology1.61046340
43MP0000747_muscle_weakness1.58403673
44MP0010630_abnormal_cardiac_muscle1.55302543
45MP0003186_abnormal_redox_activity1.54634403
46MP0003121_genomic_imprinting1.50734355
47MP0002106_abnormal_muscle_physiology1.50212648
48MP0001544_abnormal_cardiovascular_syste1.49987253
49MP0005385_cardiovascular_system_phenoty1.49987253
50MP0008007_abnormal_cellular_replicative1.48693495
51MP0008995_early_reproductive_senescence1.48368679
52MP0003786_premature_aging1.47391038
53MP0000049_abnormal_middle_ear1.47200149
54MP0003942_abnormal_urinary_system1.38506195
55MP0001764_abnormal_homeostasis1.38221997
56MP0000778_abnormal_nervous_system1.35451348
57MP0005380_embryogenesis_phenotype1.31843798
58MP0001672_abnormal_embryogenesis/_devel1.31843798
59MP0005332_abnormal_amino_acid1.29797222
60MP0002938_white_spotting1.29779599
61MP0004233_abnormal_muscle_weight1.29391535
62MP0003984_embryonic_growth_retardation1.29315319
63MP0006138_congestive_heart_failure1.29065599
64MP0003890_abnormal_embryonic-extraembry1.27971066
65MP0003950_abnormal_plasma_membrane1.27411952
66MP0004145_abnormal_muscle_electrophysio1.27171989
67MP0001697_abnormal_embryo_size1.27015357
68MP0008789_abnormal_olfactory_epithelium1.26101703
69MP0000358_abnormal_cell_content/1.25436680
70MP0002127_abnormal_cardiovascular_syste1.24888314
71MP0005620_abnormal_muscle_contractility1.24558891
72MP0002210_abnormal_sex_determination1.24464581
73MP0003315_abnormal_perineum_morphology1.24396145
74MP0002088_abnormal_embryonic_growth/wei1.24013076
75MP0005666_abnormal_adipose_tissue1.23643902
76MP0002972_abnormal_cardiac_muscle1.23302035
77MP0009672_abnormal_birth_weight1.20219798
78MP0000350_abnormal_cell_proliferation1.19562985
79MP0003137_abnormal_impulse_conducting1.18632331
80MP0005499_abnormal_olfactory_system1.18130380
81MP0005394_taste/olfaction_phenotype1.18130380
82MP0003937_abnormal_limbs/digits/tail_de1.17515712
83MP0005266_abnormal_metabolism1.16732529
84MP0003861_abnormal_nervous_system1.15952814
85MP0002080_prenatal_lethality1.15392249
86MP0000678_abnormal_parathyroid_gland1.14623923
87MP0006276_abnormal_autonomic_nervous1.14105698
88MP0005389_reproductive_system_phenotype1.14009985
89MP0001188_hyperpigmentation1.12283833
90MP0005319_abnormal_enzyme/_coenzyme1.11906309
91MP0003122_maternal_imprinting1.11728428
92MP0003123_paternal_imprinting1.08773221
93MP0000759_abnormal_skeletal_muscle1.08758436
94MP0003119_abnormal_digestive_system1.08743796
95MP0004142_abnormal_muscle_tone1.08229816
96MP0000631_abnormal_neuroendocrine_gland1.07834150
97MP0008875_abnormal_xenobiotic_pharmacok1.07815645
98MP0008877_abnormal_DNA_methylation1.07420280
99MP0000955_abnormal_spinal_cord1.07218511
100MP0000313_abnormal_cell_death1.06627690
101MP0010307_abnormal_tumor_latency1.06546520
102MP0001529_abnormal_vocalization1.04147771
103MP0005369_muscle_phenotype1.00531318
104MP0002697_abnormal_eye_size0.99213883
105MP0002249_abnormal_larynx_morphology0.97957474
106MP0009697_abnormal_copulation0.97538396
107MP0003787_abnormal_imprinting0.97534042
108MP0005451_abnormal_body_composition0.97257946
109MP0001286_abnormal_eye_development0.97090978
110MP0005423_abnormal_somatic_nervous0.96344669
111MP0003011_delayed_dark_adaptation0.94943829
112MP0002184_abnormal_innervation0.94098214
113MP0004185_abnormal_adipocyte_glucose0.93156356
114MP0004484_altered_response_of0.92815673
115MP0003191_abnormal_cellular_cholesterol0.92208758
116MP0002084_abnormal_developmental_patter0.91373966
117MP0000490_abnormal_crypts_of0.91192486
118MP0010329_abnormal_lipoprotein_level0.91166900
119MP0001145_abnormal_male_reproductive0.90631856
120MP0001853_heart_inflammation0.90093899
121MP0004147_increased_porphyrin_level0.88238103
122MP0001919_abnormal_reproductive_system0.87463104
123MP0002752_abnormal_somatic_nervous0.87353725
124MP0001348_abnormal_lacrimal_gland0.85678640
125MP0002019_abnormal_tumor_incidence0.84883366
126MP0003938_abnormal_ear_development0.84454868
127MP0002152_abnormal_brain_morphology0.84078895
128MP0002089_abnormal_postnatal_growth/wei0.83295271
129MP0003283_abnormal_digestive_organ0.83134822
130MP0004133_heterotaxia0.83058692
131MP0004197_abnormal_fetal_growth/weight/0.81547611
132MP0004859_abnormal_synaptic_plasticity0.81303092
133MP0003385_abnormal_body_wall0.80794005
134MP0001545_abnormal_hematopoietic_system0.80505350
135MP0005397_hematopoietic_system_phenotyp0.80505350
136MP0000537_abnormal_urethra_morphology0.80361578
137MP0000653_abnormal_sex_gland0.79782588
138MP0006054_spinal_hemorrhage0.78411041
139MP0003656_abnormal_erythrocyte_physiolo0.77326281
140MP0002272_abnormal_nervous_system0.76745529
141MP0002653_abnormal_ependyma_morphology0.76346348
142MP0001929_abnormal_gametogenesis0.75997671
143MP0002733_abnormal_thermal_nociception0.75884352
144MP0001727_abnormal_embryo_implantation0.75804884
145MP0004808_abnormal_hematopoietic_stem0.75545257
146MP0002092_abnormal_eye_morphology0.75475486
147MP0009053_abnormal_anal_canal0.74876926
148MP0002234_abnormal_pharynx_morphology0.74732199
149MP0000266_abnormal_heart_morphology0.74395245
150MP0005083_abnormal_biliary_tract0.74049276
151MP0003698_abnormal_male_reproductive0.73268747
152MP0002085_abnormal_embryonic_tissue0.72915614
153MP0002086_abnormal_extraembryonic_tissu0.72882767
154MP0000609_abnormal_liver_physiology0.71947262
155MP0001661_extended_life_span0.70926996
156MP0005584_abnormal_enzyme/coenzyme_acti0.70821985
157MP0000343_altered_response_to0.69173797
158MP0000598_abnormal_liver_morphology0.68352385
159MP0002332_abnormal_exercise_endurance0.67601057

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)4.42534859
2Hepatocellular necrosis (HP:0001404)4.08566369
3Increased serum pyruvate (HP:0003542)3.77815270
4Abnormality of glycolysis (HP:0004366)3.77815270
5Abnormal mitochondria in muscle tissue (HP:0008316)3.70957399
6Acute necrotizing encephalopathy (HP:0006965)3.65108146
7Rhabdomyolysis (HP:0003201)3.64521308
8Increased CSF lactate (HP:0002490)3.63905022
9Myoglobinuria (HP:0002913)3.60373267
10Acute encephalopathy (HP:0006846)3.53204269
11Hyperglycinemia (HP:0002154)3.50162245
12Mitochondrial inheritance (HP:0001427)3.45661413
13Abnormality of dicarboxylic acid metabolism (HP:0010995)3.44945570
14Dicarboxylic aciduria (HP:0003215)3.44945570
15Hyperglycinuria (HP:0003108)3.42604522
16Cerebral edema (HP:0002181)3.42207001
17Increased muscle lipid content (HP:0009058)3.32733719
18Birth length less than 3rd percentile (HP:0003561)3.31146659
19Reticulocytopenia (HP:0001896)3.30614282
20Increased serum lactate (HP:0002151)3.28293629
21Lactic acidosis (HP:0003128)3.24906746
22Abnormality of serine family amino acid metabolism (HP:0010894)3.24257489
23Abnormality of glycine metabolism (HP:0010895)3.24257489
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.21758859
25Decreased activity of mitochondrial respiratory chain (HP:0008972)3.21758859
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.21444498
27Abnormality of alanine metabolism (HP:0010916)3.21444498
28Hyperalaninemia (HP:0003348)3.21444498
29Abnormality of cells of the erythroid lineage (HP:0012130)3.20043279
30Increased intramyocellular lipid droplets (HP:0012240)3.18263527
31Abnormal number of erythroid precursors (HP:0012131)3.17931540
32Ragged-red muscle fibers (HP:0003200)3.15310343
33Aplasia/Hypoplasia of the sacrum (HP:0008517)3.14273331
34Abnormality of fatty-acid metabolism (HP:0004359)3.08388413
35Sudden death (HP:0001699)3.04223438
36Lipid accumulation in hepatocytes (HP:0006561)2.98368419
37Exercise-induced muscle cramps (HP:0003710)2.89494547
38Progressive macrocephaly (HP:0004481)2.89276677
39Ventricular tachycardia (HP:0004756)2.85574884
40Rib fusion (HP:0000902)2.81549468
41Abnormality of serum amino acid levels (HP:0003112)2.80887566
42Increased hepatocellular lipid droplets (HP:0006565)2.80651398
43Exercise intolerance (HP:0003546)2.74745981
44Hyperammonemia (HP:0001987)2.72562071
45Abnormal number of incisors (HP:0011064)2.70124391
46Horseshoe kidney (HP:0000085)2.64487564
47Lipoatrophy (HP:0100578)2.64366489
48Exercise-induced myalgia (HP:0003738)2.62862759
49Lethargy (HP:0001254)2.62768377
50Palpitations (HP:0001962)2.58950174
51Calf muscle hypertrophy (HP:0008981)2.58686653
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.54807058
53Respiratory failure (HP:0002878)2.54774121
54Nausea (HP:0002018)2.52029186
55Multiple enchondromatosis (HP:0005701)2.49333153
56Progressive muscle weakness (HP:0003323)2.49211416
57Hypoglycemic coma (HP:0001325)2.49163921
58Muscle hypertrophy of the lower extremities (HP:0008968)2.45406130
59Abnormality of pyrimidine metabolism (HP:0004353)2.42584990
60Macrocytic anemia (HP:0001972)2.42494138
61Ketosis (HP:0001946)2.37813719
62Abnormality of the labia minora (HP:0012880)2.34749496
63Myokymia (HP:0002411)2.32285680
64Generalized aminoaciduria (HP:0002909)2.30328093
65Hyperthyroidism (HP:0000836)2.30287533
66Methylmalonic aciduria (HP:0012120)2.29402983
67CNS demyelination (HP:0007305)2.27698414
68Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.26355183
69Degeneration of anterior horn cells (HP:0002398)2.22442375
70Abnormality of the anterior horn cell (HP:0006802)2.22442375
71Dilated cardiomyopathy (HP:0001644)2.21749059
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.21052142
73Muscle fiber splitting (HP:0003555)2.19666228
7411 pairs of ribs (HP:0000878)2.18602704
75Absent thumb (HP:0009777)2.16601468
76Breast hypoplasia (HP:0003187)2.16278251
77Oral leukoplakia (HP:0002745)2.15359859
78Aplasia/Hypoplasia of the patella (HP:0006498)2.14609164
79Hypoplasia of the pons (HP:0012110)2.12030613
80Megaloblastic anemia (HP:0001889)2.11368504
81Respiratory difficulties (HP:0002880)2.11029918
82Abnormality of DNA repair (HP:0003254)2.10480553
83Hypoplasia of the radius (HP:0002984)2.09904748
84Patellar aplasia (HP:0006443)2.08782848
85Emotional lability (HP:0000712)2.07949819
86Pancytopenia (HP:0001876)2.07311905
87Abnormality of reticulocytes (HP:0004312)2.07036593
88Abnormality of the preputium (HP:0100587)2.06973059
893-Methylglutaconic aciduria (HP:0003535)2.05801322
90Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.05120605
91Chromsome breakage (HP:0040012)2.04711347
92Truncus arteriosus (HP:0001660)2.04101185
93Cerebral hypomyelination (HP:0006808)2.03638684
94Abnormality of cochlea (HP:0000375)2.01184013
95Abnormality of the umbilical cord (HP:0010881)2.00516251
96Pallor (HP:0000980)1.97988578
97Microvesicular hepatic steatosis (HP:0001414)1.96554574
98Supraventricular tachycardia (HP:0004755)1.95055169
99Atrial fibrillation (HP:0005110)1.94824608
100Abnormality of the pons (HP:0007361)1.94683545
101Ureteral duplication (HP:0000073)1.94022686
102Proximal tubulopathy (HP:0000114)1.92902751
103Renal Fanconi syndrome (HP:0001994)1.92448583
104Calcaneovalgus deformity (HP:0001848)1.92043150
105Duplicated collecting system (HP:0000081)1.91755056
106Hypoplastic pelvis (HP:0008839)1.91001862
107Selective tooth agenesis (HP:0001592)1.89297668
108Spastic diplegia (HP:0001264)1.88486115
109Supraventricular arrhythmia (HP:0005115)1.87837115
110Absent radius (HP:0003974)1.85201022
111Pendular nystagmus (HP:0012043)1.85168951
112Meckel diverticulum (HP:0002245)1.84641542
113Abnormality of chromosome stability (HP:0003220)1.84013884
114Metabolic acidosis (HP:0001942)1.82669022
115Exertional dyspnea (HP:0002875)1.82158395
116Subaortic stenosis (HP:0001682)1.80439934
117Abnormality of the left ventricular outflow tract (HP:0011103)1.80439934
118Toxemia of pregnancy (HP:0100603)1.80313140
119Optic nerve coloboma (HP:0000588)1.80162599
120Carpal bone hypoplasia (HP:0001498)1.79917432
121Optic disc pallor (HP:0000543)1.79735988
122Testicular atrophy (HP:0000029)1.79346010
123Gliosis (HP:0002171)1.78509810
124Neoplasm of head and neck (HP:0012288)1.78047263
125Esophageal neoplasm (HP:0100751)1.78047263
126Delayed CNS myelination (HP:0002188)1.77090072
127Deep palmar crease (HP:0006191)1.75426613
128Deformed tarsal bones (HP:0008119)1.74284387
129Ectopic kidney (HP:0000086)1.74102192
130Poor suck (HP:0002033)1.73565341
131Septo-optic dysplasia (HP:0100842)1.70850215
132Impulsivity (HP:0100710)1.70362854
133Leukodystrophy (HP:0002415)1.69416842
134Microretrognathia (HP:0000308)1.66673939
135Methylmalonic acidemia (HP:0002912)1.66287599
136Myopathic facies (HP:0002058)1.64874965
137High anterior hairline (HP:0009890)1.63735106
138CNS hypomyelination (HP:0003429)1.60677750
139Slender long bone (HP:0003100)1.58382450
140Type II lissencephaly (HP:0007260)1.57656705
141Morphological abnormality of the inner ear (HP:0011390)1.57485467
142Myotonia (HP:0002486)1.56669412
143Homocystinuria (HP:0002156)1.55681676
144Abnormality of homocysteine metabolism (HP:0010919)1.55681676
145Patent foramen ovale (HP:0001655)1.55592622
146Duplication of thumb phalanx (HP:0009942)1.55337087
147Colon cancer (HP:0003003)1.54409997
148Sclerocornea (HP:0000647)1.54360539
149Abnormality of the ileum (HP:0001549)1.53354858
150Cortical dysplasia (HP:0002539)1.53351305
151Aplasia/Hypoplasia of the uvula (HP:0010293)1.53262395
152Triphalangeal thumb (HP:0001199)1.52617766

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK15.52849927
2BCKDK3.98531561
3WEE13.53107893
4BUB13.37255207
5VRK23.34980866
6STK163.34190602
7NME22.80250337
8NEK22.75044330
9PDK32.71805259
10PDK42.71805259
11EIF2AK12.53385433
12SRPK12.42577826
13CDC72.36712262
14MKNK12.25939761
15EEF2K2.14229813
16TSSK62.02273552
17TTN2.01936935
18SMG11.97031702
19TTK1.95361861
20OBSCN1.88223599
21PKN21.80467934
22DYRK21.79134867
23STK38L1.72818097
24WNK41.67328644
25PLK11.51170909
26PAK41.50307593
27ARAF1.44448813
28EIF2AK31.42687719
29DMPK1.39574011
30MAP2K31.35896465
31CCNB11.34981902
32FLT31.33314222
33MAP3K91.32992474
34VRK11.26780251
35AURKB1.26604734
36ACVR1B1.26483777
37CDK41.24592408
38PDK21.22168622
39ATR1.18702196
40PLK41.14767745
41EIF2AK21.13208147
42TESK21.12329675
43MAP4K11.09090396
44MYLK1.07410003
45MKNK21.07147960
46PNCK1.06104620
47EPHB21.05734406
48TAF11.04483159
49CDK71.03754079
50SCYL21.01065423
51PRKCI1.00824914
52MAP3K110.99476065
53SIK20.96172280
54CASK0.92772949
55IRAK30.92756372
56AURKA0.92675016
57TGFBR10.92661912
58TYRO30.90948249
59TIE10.89613732
60RPS6KA50.89531772
61RPS6KB20.89525429
62PLK30.88291217
63NME10.86641314
64BRSK20.86347586
65CHEK20.85789124
66SIK10.84881014
67MAP2K70.81744713
68CSNK2A20.81179018
69MAP3K80.80954800
70CDK60.79538798
71PASK0.79328631
72AKT20.78795681
73MAPKAPK50.76846888
74ICK0.76241828
75PHKG10.75899791
76PHKG20.75899791
77RPS6KA20.75839621
78ABL20.75540244
79KDR0.75477635
80ZAK0.74163730
81BMPR1B0.73580131
82PIK3CA0.72624338
83PINK10.72273150
84CHEK10.72198561
85STK40.71732044
86TLK10.67757996
87MARK10.65841292
88PBK0.63021760
89DYRK30.62175925
90LMTK20.60965362
91TRIB30.60548536
92CDK11A0.60463662
93CSNK1G30.59773702
94CSNK2A10.59110622
95BTK0.58114586
96RPS6KA10.55512035
97CSNK1G20.55078525
98CDK20.53637431
99ATM0.53098528
100CDK150.52954242
101GRK10.52435869
102MAP2K60.51108502
103MAP3K40.50748797
104TAOK20.50146718
105PKN10.49225370
106TNIK0.48867491
107RPS6KA60.48188815
108CDK140.47894130
109ALK0.46664372
110PRKCG0.44594710
111MAPK140.44238151
112PIM20.43510678
113CDK190.42507207
114BRSK10.41669366
115PRKACB0.40542850
116BRAF0.40474867
117PAK10.40206036
118DAPK30.39500187
119CDK80.38423919
120KIT0.37876238
121CDK10.35419847
122CSNK1E0.34014753
123ILK0.33470164
124TEC0.31658013
125PTK60.31413855
126PIM10.29758222
127MAPK110.26241151
128CAMK10.26070200
129PRKDC0.25508133
130MAP3K50.25309779
131STK240.23847305
132MUSK0.22956567
133MAP3K100.21597555
134NTRK20.21582549
135MTOR0.20130301
136RAF10.20007333
137CSF1R0.19640171
138JAK30.19395864

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.63867509
2DNA replication_Homo sapiens_hsa030303.58216737
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.47847711
4Mismatch repair_Homo sapiens_hsa034302.96687772
5Proteasome_Homo sapiens_hsa030502.87158802
6Ribosome_Homo sapiens_hsa030102.78565059
7Propanoate metabolism_Homo sapiens_hsa006402.48091893
8Carbon metabolism_Homo sapiens_hsa012002.35326633
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.32860069
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.32386342
11RNA polymerase_Homo sapiens_hsa030202.29692277
12One carbon pool by folate_Homo sapiens_hsa006702.25072955
13Spliceosome_Homo sapiens_hsa030402.14178049
14Base excision repair_Homo sapiens_hsa034102.11598840
15Parkinsons disease_Homo sapiens_hsa050122.06569736
16Biosynthesis of amino acids_Homo sapiens_hsa012302.02668778
17Oxidative phosphorylation_Homo sapiens_hsa001901.93021090
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.92666008
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86463422
20RNA transport_Homo sapiens_hsa030131.86447239
21Pyrimidine metabolism_Homo sapiens_hsa002401.85604439
22Fatty acid degradation_Homo sapiens_hsa000711.85586743
23Homologous recombination_Homo sapiens_hsa034401.84612412
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.78462256
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.74568682
26Nucleotide excision repair_Homo sapiens_hsa034201.70467227
27Pyruvate metabolism_Homo sapiens_hsa006201.68307733
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59978211
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.59676222
30Fatty acid elongation_Homo sapiens_hsa000621.52109900
31Fanconi anemia pathway_Homo sapiens_hsa034601.51813130
32Huntingtons disease_Homo sapiens_hsa050161.48554759
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.45216840
34Fatty acid metabolism_Homo sapiens_hsa012121.45189526
35Vitamin B6 metabolism_Homo sapiens_hsa007501.43383204
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.34768219
37Protein export_Homo sapiens_hsa030601.32361832
38Pentose phosphate pathway_Homo sapiens_hsa000301.27472591
39Cell cycle_Homo sapiens_hsa041101.23850585
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.21983164
41Cardiac muscle contraction_Homo sapiens_hsa042601.20958435
42Alzheimers disease_Homo sapiens_hsa050101.19984558
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16424696
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13916257
45Non-homologous end-joining_Homo sapiens_hsa034501.12889835
46Steroid biosynthesis_Homo sapiens_hsa001001.11411161
47Sulfur relay system_Homo sapiens_hsa041221.11145265
48RNA degradation_Homo sapiens_hsa030181.10685501
49Selenocompound metabolism_Homo sapiens_hsa004501.10608295
50Arginine biosynthesis_Homo sapiens_hsa002201.08407805
51Purine metabolism_Homo sapiens_hsa002301.07451175
52Folate biosynthesis_Homo sapiens_hsa007901.04646523
53Butanoate metabolism_Homo sapiens_hsa006501.03197061
54Basal transcription factors_Homo sapiens_hsa030221.02040735
55Peroxisome_Homo sapiens_hsa041461.00571073
56beta-Alanine metabolism_Homo sapiens_hsa004100.98724069
57Fructose and mannose metabolism_Homo sapiens_hsa000510.98153989
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92899753
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90769047
60Arginine and proline metabolism_Homo sapiens_hsa003300.83199071
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82945232
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82216127
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.81236423
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80797452
65Basal cell carcinoma_Homo sapiens_hsa052170.79686907
66Glutathione metabolism_Homo sapiens_hsa004800.75617324
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74917366
68PPAR signaling pathway_Homo sapiens_hsa033200.73479788
69Tryptophan metabolism_Homo sapiens_hsa003800.72125447
70Metabolic pathways_Homo sapiens_hsa011000.71724593
71Lysine degradation_Homo sapiens_hsa003100.70205265
72mRNA surveillance pathway_Homo sapiens_hsa030150.65983276
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65210497
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62560976
75Phototransduction_Homo sapiens_hsa047440.61363526
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58598761
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56237622
78Galactose metabolism_Homo sapiens_hsa000520.53779320
79Hedgehog signaling pathway_Homo sapiens_hsa043400.52308879
80Oocyte meiosis_Homo sapiens_hsa041140.46721115
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46165111
82Hippo signaling pathway_Homo sapiens_hsa043900.45514750
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44269077
84Phenylalanine metabolism_Homo sapiens_hsa003600.43781860
85Fat digestion and absorption_Homo sapiens_hsa049750.42284864
86Nicotine addiction_Homo sapiens_hsa050330.42257539
87Systemic lupus erythematosus_Homo sapiens_hsa053220.39798874
88Epstein-Barr virus infection_Homo sapiens_hsa051690.38667388
89Starch and sucrose metabolism_Homo sapiens_hsa005000.38383311
90Alcoholism_Homo sapiens_hsa050340.37172927
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35313199
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32560014
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31086634
94Thyroid cancer_Homo sapiens_hsa052160.30631114
95p53 signaling pathway_Homo sapiens_hsa041150.29344694
96Caffeine metabolism_Homo sapiens_hsa002320.27970828
97Wnt signaling pathway_Homo sapiens_hsa043100.27678826
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27303779
99Axon guidance_Homo sapiens_hsa043600.26734839
100Notch signaling pathway_Homo sapiens_hsa043300.26509910
101N-Glycan biosynthesis_Homo sapiens_hsa005100.25584682
102Glycerolipid metabolism_Homo sapiens_hsa005610.25159366
103Tyrosine metabolism_Homo sapiens_hsa003500.24559018
104Synaptic vesicle cycle_Homo sapiens_hsa047210.23775546
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.23095236
106Retinol metabolism_Homo sapiens_hsa008300.22052844
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21332021
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.20440981
109Dilated cardiomyopathy_Homo sapiens_hsa054140.18655999
110Collecting duct acid secretion_Homo sapiens_hsa049660.18016496
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16678252
112Regulation of autophagy_Homo sapiens_hsa041400.16593806
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.14002356
114Linoleic acid metabolism_Homo sapiens_hsa005910.13842702
115Vitamin digestion and absorption_Homo sapiens_hsa049770.13463550
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.13349676
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.12387970
118Olfactory transduction_Homo sapiens_hsa047400.12352618
119Glucagon signaling pathway_Homo sapiens_hsa049220.11620212
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.11217196
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11206858
122Chemical carcinogenesis_Homo sapiens_hsa052040.11111653
123Viral carcinogenesis_Homo sapiens_hsa052030.09999947
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.09945998
125Herpes simplex infection_Homo sapiens_hsa051680.09337817

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