ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.49308328
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.38503087
3	ATP synthesis coupled proton transport (GO:0015986)	6.38503087
4	viral transcription (GO:0019083)	6.35443801
5	chaperone-mediated protein transport (GO:0072321)	6.24130056
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.13248751
7	translational termination (GO:0006415)	6.09986707
8	maturation of SSU-rRNA (GO:0030490)	6.09708217
9	DNA deamination (GO:0045006)	5.79571387
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.68107061
11	protein neddylation (GO:0045116)	5.61797939
12	protein targeting to ER (GO:0045047)	5.57555905
13	cotranslational protein targeting to membrane (GO:0006613)	5.56278111
14	ribosomal small subunit biogenesis (GO:0042274)	5.47162971
15	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.26214282
16	protein localization to endoplasmic reticulum (GO:0070972)	5.25315378
17	translational elongation (GO:0006414)	5.03903409
18	behavioral response to nicotine (GO:0035095)	5.03587485
19	cytidine deamination (GO:0009972)	4.88705490
20	cytidine metabolic process (GO:0046087)	4.88705490
21	cytidine catabolic process (GO:0006216)	4.88705490
22	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.83165992
23	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.75482937
24	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	4.67902154
25	respiratory electron transport chain (GO:0022904)	4.53013958
26	viral life cycle (GO:0019058)	4.50592447
27	cellular protein complex disassembly (GO:0043624)	4.46298675
28	electron transport chain (GO:0022900)	4.45622665
29	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.35792049
30	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.30737349
31	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	4.25478475
32	ribosomal large subunit biogenesis (GO:0042273)	3.98729991
33	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.92705352
34	inner mitochondrial membrane organization (GO:0007007)	3.88616287
35	translational initiation (GO:0006413)	3.86328444
36	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.81970353
37	protein complex biogenesis (GO:0070271)	3.80063166
38	protein targeting to membrane (GO:0006612)	3.77332023
39	protein complex disassembly (GO:0043241)	3.76566802
40	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.72788051
41	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.72788051
42	translation (GO:0006412)	3.64028749
43	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.63155750
44	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.63155750
45	NADH dehydrogenase complex assembly (GO:0010257)	3.63155750
46	mitochondrial respiratory chain complex assembly (GO:0033108)	3.61576587
47	macromolecular complex disassembly (GO:0032984)	3.59870596
48	ATP biosynthetic process (GO:0006754)	3.43764075
49	regulation of hypersensitivity (GO:0002883)	3.42958375
50	positive regulation of defense response to virus by host (GO:0002230)	3.40832100
51	hydrogen ion transmembrane transport (GO:1902600)	3.36280994
52	positive regulation of cell fate commitment (GO:0010455)	3.34952564
53	negative regulation by host of viral transcription (GO:0043922)	3.31095565
54	positive regulation of protein homooligomerization (GO:0032464)	3.29493668
55	cell wall macromolecule catabolic process (GO:0016998)	3.27669865
56	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.25493369
57	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.21354405
58	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.20026721
59	proton transport (GO:0015992)	3.17973703
60	negative regulation of DNA-templated transcription, elongation (GO:0032785)	3.15816623
61	hydrogen transport (GO:0006818)	3.08783186
62	phenol-containing compound catabolic process (GO:0019336)	3.03052075
63	adaptation of signaling pathway (GO:0023058)	3.02208194
64	positive regulation of calcium-mediated signaling (GO:0050850)	2.98680238
65	mRNA catabolic process (GO:0006402)	2.97190159
66	positive regulation of T cell apoptotic process (GO:0070234)	2.92429146
67	positive regulation of mast cell activation (GO:0033005)	2.91770886
68	cellular component biogenesis (GO:0044085)	2.91615706
69	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.88080602
70	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.84584178
71	positive regulation of mast cell degranulation (GO:0043306)	2.84584178
72	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.84551386
73	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.84109028
74	lipopolysaccharide biosynthetic process (GO:0009103)	2.79664671
75	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	2.76000639
76	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.74375334
77	central nervous system myelination (GO:0022010)	2.74067054
78	axon ensheathment in central nervous system (GO:0032291)	2.74067054
79	cell wall macromolecule metabolic process (GO:0044036)	2.74025537
80	RNA catabolic process (GO:0006401)	2.70424494
81	protein targeting (GO:0006605)	2.68164449
82	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.67768868
83	GTP biosynthetic process (GO:0006183)	2.67636133
84	ribonucleoprotein complex biogenesis (GO:0022613)	2.63408595
85	GDP-mannose metabolic process (GO:0019673)	2.62657521
86	indolalkylamine metabolic process (GO:0006586)	2.60921931
87	eosinophil chemotaxis (GO:0048245)	2.59388416
88	neuron fate determination (GO:0048664)	2.58566374
89	rRNA processing (GO:0006364)	2.56443574
90	establishment of protein localization to membrane (GO:0090150)	2.55546036
91	N-glycan processing (GO:0006491)	2.55332521
92	lipopolysaccharide metabolic process (GO:0008653)	2.54920757
93	rRNA metabolic process (GO:0016072)	2.54473735
94	monocyte chemotaxis (GO:0002548)	2.51694571
95	regulation of mitochondrial translation (GO:0070129)	2.48350446
96	iron-sulfur cluster assembly (GO:0016226)	2.47634565
97	metallo-sulfur cluster assembly (GO:0031163)	2.47634565
98	lysosome localization (GO:0032418)	2.47484780
99	tryptophan metabolic process (GO:0006568)	2.45424889
100	nucleoside triphosphate biosynthetic process (GO:0009142)	2.45304719

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.91474495
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.60609559
3	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.49827145
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.24379841
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.04145044
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.00729927
7	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.97614422
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.79426275
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.78832775
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.76918197
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.42061450
12	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.33538305
13	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.28716989
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.23890717
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.07873091
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.00234201
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.00011559
18	ELK1_19687146_ChIP-ChIP_HELA_Human	1.92640657
19	IRF1_19129219_ChIP-ChIP_H3396_Human	1.86368973
20	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.85197000
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.70494573
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.68785128
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.65739235
24	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.64747093
25	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.61100929
26	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.60960117
27	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.60360592
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.60040210
29	TAF2_19829295_ChIP-Seq_ESCs_Human	1.59658962
30	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.53070385
31	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.51329050
32	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.51105507
33	IGF1R_20145208_ChIP-Seq_DFB_Human	1.49850224
34	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.48623236
35	TTF2_22483619_ChIP-Seq_HELA_Human	1.47676842
36	ERG_20517297_ChIP-Seq_VCAP_Human	1.43832824
37	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.43719141
38	GABP_19822575_ChIP-Seq_HepG2_Human	1.40810826
39	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.40428122
40	CIITA_25753668_ChIP-Seq_RAJI_Human	1.35210512
41	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.34698276
42	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.33741528
43	ERA_21632823_ChIP-Seq_H3396_Human	1.32334140
44	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.30971938
45	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.30522293
46	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.30166221
47	NCOR_22424771_ChIP-Seq_293T_Human	1.27911612
48	MYC_18940864_ChIP-ChIP_HL60_Human	1.26022881
49	DCP1A_22483619_ChIP-Seq_HELA_Human	1.24548138
50	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22960599
51	NANOG_20526341_ChIP-Seq_ESCs_Human	1.22591753
52	HTT_18923047_ChIP-ChIP_STHdh_Human	1.21355723
53	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.20319805
54	XRN2_22483619_ChIP-Seq_HELA_Human	1.20203931
55	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.19884419
56	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.16923403
57	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.15563417
58	MYC_19829295_ChIP-Seq_ESCs_Human	1.13744065
59	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.11430471
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11082025
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11082025
62	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.10960367
63	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10910925
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10910925
65	TAF15_26573619_Chip-Seq_HEK293_Human	1.10610033
66	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.08422456
67	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.07616608
68	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.06142252
69	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.05800563
70	KDM5A_27292631_Chip-Seq_BREAST_Human	1.03829753
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.03712359
72	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.02369671
73	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02248355
74	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.01717746
75	GBX2_23144817_ChIP-Seq_PC3_Human	1.00684839
76	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.99179094
77	EGR1_19032775_ChIP-ChIP_M12_Human	0.97446877
78	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.97399313
79	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.97203377
80	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.96556327
81	CBP_20019798_ChIP-Seq_JUKART_Human	0.96556327
82	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.96505148
83	SA1_27219007_Chip-Seq_Bcells_Human	0.95916306
84	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.95615630
85	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.95358921
86	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.94841145
87	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94526111
88	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.92950440
89	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.92317864
90	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.91140035
91	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.90566388
92	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.90463266
93	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.90172106
94	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.89746254
95	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.89726228
96	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.88865109
97	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.87884553
98	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.87424542
99	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.86912750
100	P300_19829295_ChIP-Seq_ESCs_Human	0.86836336

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.53641190
2	MP0002837_dystrophic_cardiac_calcinosis	4.61626318
3	MP0006292_abnormal_olfactory_placode	3.69203064
4	MP0003011_delayed_dark_adaptation	3.59479095
5	MP0003646_muscle_fatigue	2.93474882
6	MP0003878_abnormal_ear_physiology	2.70449527
7	MP0005377_hearing/vestibular/ear_phenot	2.70449527
8	MP0003122_maternal_imprinting	2.55769939
9	MP0001529_abnormal_vocalization	2.54024517
10	MP0002876_abnormal_thyroid_physiology	2.34299782
11	MP0010307_abnormal_tumor_latency	2.12061479
12	MP0005671_abnormal_response_to	2.09230626
13	MP0008789_abnormal_olfactory_epithelium	1.93749433
14	MP0002102_abnormal_ear_morphology	1.88017313
15	MP0001986_abnormal_taste_sensitivity	1.85182341
16	MP0005499_abnormal_olfactory_system	1.77880324
17	MP0005394_taste/olfaction_phenotype	1.77880324
18	MP0003786_premature_aging	1.77795884
19	MP0006276_abnormal_autonomic_nervous	1.72740930
20	MP0003186_abnormal_redox_activity	1.65888271
21	MP0008877_abnormal_DNA_methylation	1.58266516
22	MP0004142_abnormal_muscle_tone	1.56687309
23	MP0000049_abnormal_middle_ear	1.45407051
24	MP0001835_abnormal_antigen_presentation	1.43895943
25	MP0000372_irregular_coat_pigmentation	1.42477427
26	MP0002234_abnormal_pharynx_morphology	1.42432351
27	MP0005645_abnormal_hypothalamus_physiol	1.42325489
28	MP0002938_white_spotting	1.41978255
29	MP0003567_abnormal_fetal_cardiomyocyte	1.38096790
30	MP0009745_abnormal_behavioral_response	1.37014941
31	MP0001968_abnormal_touch/_nociception	1.35036016
32	MP0004133_heterotaxia	1.34703871
33	MP0008995_early_reproductive_senescence	1.34390002
34	MP0009046_muscle_twitch	1.31984572
35	MP0006036_abnormal_mitochondrial_physio	1.28931084
36	MP0002163_abnormal_gland_morphology	1.28684867
37	MP0008872_abnormal_physiological_respon	1.28275371
38	MP0001905_abnormal_dopamine_level	1.26857315
39	MP0001485_abnormal_pinna_reflex	1.22452212
40	MP0005360_urolithiasis	1.20813147
41	MP0002638_abnormal_pupillary_reflex	1.19259862
42	MP0005551_abnormal_eye_electrophysiolog	1.18863945
43	MP0004145_abnormal_muscle_electrophysio	1.18267851
44	MP0002160_abnormal_reproductive_system	1.17822213
45	MP0002735_abnormal_chemical_nociception	1.16477471
46	MP0002095_abnormal_skin_pigmentation	1.10599991
47	MP0005646_abnormal_pituitary_gland	1.10376611
48	MP0001542_abnormal_bone_strength	1.09632179
49	MP0002148_abnormal_hypersensitivity_rea	1.07356497
50	MP0002272_abnormal_nervous_system	1.05428680
51	MP0003890_abnormal_embryonic-extraembry	1.04305730
52	MP0001440_abnormal_grooming_behavior	1.04235632
53	MP0005389_reproductive_system_phenotype	1.03960261
54	MP0002067_abnormal_sensory_capabilities	1.03273765
55	MP0001293_anophthalmia	1.02597064
56	MP0000427_abnormal_hair_cycle	1.02068416
57	MP0002653_abnormal_ependyma_morphology	1.01608926
58	MP0001970_abnormal_pain_threshold	1.01164459
59	MP0003283_abnormal_digestive_organ	1.00025740
60	MP0003183_abnormal_peptide_metabolism	0.99475427
61	MP0006082_CNS_inflammation	0.98828936
62	MP0003121_genomic_imprinting	0.97475693
63	MP0005408_hypopigmentation	0.95945058
64	MP0002733_abnormal_thermal_nociception	0.94522909
65	MP0008775_abnormal_heart_ventricle	0.92022428
66	MP0000631_abnormal_neuroendocrine_gland	0.91013766
67	MP0009785_altered_susceptibility_to	0.90637155
68	MP0004742_abnormal_vestibular_system	0.87756987
69	MP0005075_abnormal_melanosome_morpholog	0.86233724
70	MP0001486_abnormal_startle_reflex	0.84987232
71	MP0001188_hyperpigmentation	0.84466956
72	MP0002229_neurodegeneration	0.83914065
73	MP0000013_abnormal_adipose_tissue	0.81316986
74	MP0008875_abnormal_xenobiotic_pharmacok	0.81162536
75	MP0001502_abnormal_circadian_rhythm	0.80825185
76	MP0005084_abnormal_gallbladder_morpholo	0.80755063
77	MP0002064_seizures	0.80339576
78	MP0001765_abnormal_ion_homeostasis	0.79348165
79	MP0003880_abnormal_central_pattern	0.79327509
80	MP0005253_abnormal_eye_physiology	0.78524579
81	MP0005195_abnormal_posterior_eye	0.78075201
82	MP0001919_abnormal_reproductive_system	0.77525216
83	MP0009764_decreased_sensitivity_to	0.77308149
84	MP0002734_abnormal_mechanical_nocicepti	0.74250637
85	MP0001800_abnormal_humoral_immune	0.73989786
86	MP0005174_abnormal_tail_pigmentation	0.73871435
87	MP0004215_abnormal_myocardial_fiber	0.73590439
88	MP0005379_endocrine/exocrine_gland_phen	0.72910732
89	MP0002572_abnormal_emotion/affect_behav	0.72492152
90	MP0002282_abnormal_trachea_morphology	0.72194017
91	MP0003937_abnormal_limbs/digits/tail_de	0.72020253
92	MP0004019_abnormal_vitamin_homeostasis	0.71855952
93	MP0004130_abnormal_muscle_cell	0.71589202
94	MP0002277_abnormal_respiratory_mucosa	0.69258561
95	MP0005386_behavior/neurological_phenoty	0.68992895
96	MP0004924_abnormal_behavior	0.68992895
97	MP0001756_abnormal_urination	0.68118321
98	MP0002063_abnormal_learning/memory/cond	0.67991924
99	MP0000778_abnormal_nervous_system	0.66702225
100	MP0003633_abnormal_nervous_system	0.66611589

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased hepatocellular lipid droplets (HP:0006565)	5.06550803
2	Acute necrotizing encephalopathy (HP:0006965)	4.71601635
3	Lipid accumulation in hepatocytes (HP:0006561)	4.60717278
4	Mitochondrial inheritance (HP:0001427)	4.54552530
5	Abnormality of cells of the erythroid lineage (HP:0012130)	4.51500768
6	Increased intramyocellular lipid droplets (HP:0012240)	4.46559992
7	Reticulocytopenia (HP:0001896)	4.34159324
8	Renal Fanconi syndrome (HP:0001994)	4.33579942
9	3-Methylglutaconic aciduria (HP:0003535)	4.33282772
10	Abnormal mitochondria in muscle tissue (HP:0008316)	4.30437094
11	Abnormal number of erythroid precursors (HP:0012131)	3.92544407
12	Progressive macrocephaly (HP:0004481)	3.85673646
13	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.85199453
14	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.85199453
15	Increased CSF lactate (HP:0002490)	3.81432279
16	Increased muscle lipid content (HP:0009058)	3.74977313
17	Acute encephalopathy (HP:0006846)	3.65304415
18	Colon cancer (HP:0003003)	3.56422797
19	Exertional dyspnea (HP:0002875)	3.53963610
20	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.43209493
21	Hepatocellular necrosis (HP:0001404)	3.40901476
22	Molar tooth sign on MRI (HP:0002419)	3.33660778
23	Abnormality of midbrain morphology (HP:0002418)	3.33660778
24	Genetic anticipation (HP:0003743)	3.25996336
25	Abnormality of renal resorption (HP:0011038)	3.19073106
26	Hepatic necrosis (HP:0002605)	3.08396998
27	Cerebral edema (HP:0002181)	3.06668621
28	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.96871160
29	Agitation (HP:0000713)	2.92411155
30	Recurrent cutaneous fungal infections (HP:0011370)	2.72950971
31	Chronic mucocutaneous candidiasis (HP:0002728)	2.72950971
32	IgG deficiency (HP:0004315)	2.71157869
33	Macrocytic anemia (HP:0001972)	2.64265890
34	Absent thumb (HP:0009777)	2.61035849
35	Pendular nystagmus (HP:0012043)	2.55532306
36	Pancreatic cysts (HP:0001737)	2.54777072
37	Lactic acidosis (HP:0003128)	2.45514082
38	Type I transferrin isoform profile (HP:0003642)	2.42487859
39	Pallor (HP:0000980)	2.40745544
40	Increased serum lactate (HP:0002151)	2.40429693
41	Microretrognathia (HP:0000308)	2.36331161
42	Pancreatic fibrosis (HP:0100732)	2.29715959
43	Respiratory failure (HP:0002878)	2.29061270
44	Respiratory difficulties (HP:0002880)	2.25793241
45	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.25373153
46	Sclerocornea (HP:0000647)	2.24487222
47	Optic disc pallor (HP:0000543)	2.23654306
48	Progressive cerebellar ataxia (HP:0002073)	2.22501467
49	Congenital stationary night blindness (HP:0007642)	2.20359150
50	Myokymia (HP:0002411)	2.15407801
51	Exercise intolerance (HP:0003546)	2.14560653
52	11 pairs of ribs (HP:0000878)	2.14462564
53	Failure to thrive in infancy (HP:0001531)	2.12590144
54	True hermaphroditism (HP:0010459)	2.12468237
55	Stomatitis (HP:0010280)	2.10730405
56	Partial duplication of thumb phalanx (HP:0009944)	2.08188702
57	T lymphocytopenia (HP:0005403)	2.08068730
58	Septo-optic dysplasia (HP:0100842)	2.06892340
59	Abolished electroretinogram (ERG) (HP:0000550)	2.06507687
60	Dyskinesia (HP:0100660)	2.04613562
61	Abnormality of the prostate (HP:0008775)	2.04113547
62	Abnormality of DNA repair (HP:0003254)	2.02883419
63	Nephronophthisis (HP:0000090)	2.01085423
64	CNS demyelination (HP:0007305)	1.93768597
65	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.93072322
66	Leukodystrophy (HP:0002415)	1.92015458
67	Asplenia (HP:0001746)	1.91795320
68	Abnormality of T cell number (HP:0011839)	1.91324791
69	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.87261931
70	Abnormal protein N-linked glycosylation (HP:0012347)	1.87261931
71	Abnormal protein glycosylation (HP:0012346)	1.87261931
72	Abnormal glycosylation (HP:0012345)	1.87261931
73	Abdominal situs inversus (HP:0003363)	1.84243372
74	Abnormality of abdominal situs (HP:0011620)	1.84243372
75	Hyperphosphaturia (HP:0003109)	1.83869331
76	Carpal bone hypoplasia (HP:0001498)	1.83737448
77	Flat capital femoral epiphysis (HP:0003370)	1.82375588
78	Abnormality of urine glucose concentration (HP:0011016)	1.82374547
79	Glycosuria (HP:0003076)	1.82374547
80	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.79619156
81	Abnormality of alanine metabolism (HP:0010916)	1.79619156
82	Hyperalaninemia (HP:0003348)	1.79619156
83	Panhypogammaglobulinemia (HP:0003139)	1.79184471
84	Polyphagia (HP:0002591)	1.76370857
85	Partial duplication of the phalanx of hand (HP:0009999)	1.75792781
86	Restlessness (HP:0000711)	1.75258238
87	Renal cortical cysts (HP:0000803)	1.73685162
88	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.72022049
89	Hyperthyroidism (HP:0000836)	1.67987487
90	Retinal dysplasia (HP:0007973)	1.67897645
91	Thrombocytosis (HP:0001894)	1.65824611
92	Depressed nasal ridge (HP:0000457)	1.64732979
93	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.64225158
94	Type II lissencephaly (HP:0007260)	1.64047056
95	Limb dystonia (HP:0002451)	1.59205445
96	Agammaglobulinemia (HP:0004432)	1.57207601
97	Abnormality of glycolipid metabolism (HP:0010969)	1.56719218
98	Abnormality of liposaccharide metabolism (HP:0010968)	1.56719218
99	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.56719218
100	Ketosis (HP:0001946)	1.55425324

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.88340611
2	CDK19	3.81998182
3	PIK3CA	2.88319489
4	TLK1	2.67313968
5	WNK3	2.55670197
6	WNK4	2.54061074
7	TIE1	2.51759495
8	PINK1	2.49289912
9	BCKDK	2.49274022
10	MAP2K7	2.29675604
11	STK16	2.22006478
12	MAP3K12	2.21691066
13	GRK7	2.18892481
14	MYLK	2.12136707
15	DYRK2	1.77127361
16	PAK3	1.70683278
17	OXSR1	1.69305836
18	ADRBK2	1.58843785
19	FRK	1.56720013
20	STK39	1.55026815
21	KDR	1.51535616
22	EPHB2	1.47746509
23	MAP2K4	1.46861516
24	PLK4	1.45113934
25	DMPK	1.41425221
26	NME2	1.33938723
27	GRK1	1.21017960
28	DYRK3	1.20959566
29	ARAF	1.19857583
30	ADRBK1	0.99442011
31	CSF1R	0.98630553
32	MAPK13	0.97656743
33	RPS6KA4	0.92382036
34	TAOK3	0.91844832
35	NUAK1	0.91515778
36	NTRK1	0.91346685
37	IKBKB	0.91137056
38	ABL2	0.90344705
39	MINK1	0.89936165
40	IKBKE	0.88586702
41	CSNK1G2	0.87694898
42	MAP4K2	0.86060944
43	MAP2K6	0.83367482
44	PRKCQ	0.81486213
45	KIT	0.81417639
46	ITK	0.80721305
47	CAMK1	0.79108638
48	PRKCE	0.75207353
49	MARK1	0.74568810
50	BMPR2	0.74311093
51	PIM2	0.73666944
52	RPS6KA5	0.73306058
53	PRKCG	0.72712152
54	INSRR	0.72142481
55	TEC	0.70428061
56	NTRK2	0.68421973
57	CSNK1G3	0.68016573
58	MAPKAPK3	0.66233358
59	AURKA	0.65314700
60	FES	0.64523004
61	LIMK1	0.62152385
62	CSNK2A2	0.61341435
63	MAP3K4	0.61102899
64	STK11	0.60768402
65	PRKACA	0.59743980
66	RPS6KA6	0.58553833
67	TYK2	0.55471560
68	CAMKK2	0.52987123
69	LRRK2	0.52195439
70	OBSCN	0.52073807
71	CAMK2D	0.50142526
72	ZAK	0.50000817
73	ILK	0.49760535
74	PRKCD	0.49410619
75	CAMK2A	0.48677909
76	PHKG2	0.48663766
77	PHKG1	0.48663766
78	CSNK1G1	0.48471770
79	CSNK2A1	0.47729745
80	CSNK1A1	0.47339333
81	RPS6KL1	0.46531532
82	RPS6KC1	0.46531532
83	CASK	0.46150558
84	ATR	0.45981957
85	MAP3K11	0.45280251
86	CHEK2	0.44358545
87	VRK2	0.43762603
88	CSNK1A1L	0.43155590
89	CDK14	0.42747062
90	CSNK1E	0.40403405
91	PRKCA	0.40118594
92	DYRK1A	0.39615523
93	CAMK2G	0.38913548
94	CDK3	0.38851269
95	EIF2AK3	0.37715031
96	PIK3CG	0.37187842
97	PLK2	0.35484697
98	MUSK	0.35223464
99	MAPK12	0.35221308
100	PAK1	0.34874628

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.63710212
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.71810292
3	Parkinsons disease_Homo sapiens_hsa05012	3.85575626
4	Proteasome_Homo sapiens_hsa03050	3.23132063
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.13653714
6	Protein export_Homo sapiens_hsa03060	3.08494653
7	Asthma_Homo sapiens_hsa05310	3.00335042
8	Alzheimers disease_Homo sapiens_hsa05010	2.83353455
9	Huntingtons disease_Homo sapiens_hsa05016	2.63560589
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.51470128
11	Cardiac muscle contraction_Homo sapiens_hsa04260	2.49951584
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.24560211
13	Graft-versus-host disease_Homo sapiens_hsa05332	2.20009277
14	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.95103987
15	Primary immunodeficiency_Homo sapiens_hsa05340	1.86730582
16	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.86020778
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.79432720
18	Allograft rejection_Homo sapiens_hsa05330	1.72424118
19	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.67942998
20	RNA polymerase_Homo sapiens_hsa03020	1.54523336
21	Butanoate metabolism_Homo sapiens_hsa00650	1.48437690
22	Antigen processing and presentation_Homo sapiens_hsa04612	1.41489469
23	Rheumatoid arthritis_Homo sapiens_hsa05323	1.41090699
24	Propanoate metabolism_Homo sapiens_hsa00640	1.39235599
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.27827588
26	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.14879130
27	Type I diabetes mellitus_Homo sapiens_hsa04940	1.14857770
28	Peroxisome_Homo sapiens_hsa04146	1.13694190
29	Regulation of autophagy_Homo sapiens_hsa04140	1.10834372
30	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.09981066
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.08631353
32	Homologous recombination_Homo sapiens_hsa03440	1.05422898
33	Fatty acid degradation_Homo sapiens_hsa00071	0.99953475
34	Fanconi anemia pathway_Homo sapiens_hsa03460	0.99798847
35	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.99101816
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.96611875
37	RNA degradation_Homo sapiens_hsa03018	0.87950465
38	Nitrogen metabolism_Homo sapiens_hsa00910	0.85977411
39	Pyrimidine metabolism_Homo sapiens_hsa00240	0.83933132
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.83038185
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.80077136
42	Mismatch repair_Homo sapiens_hsa03430	0.74107989
43	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.73217047
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.69975366
45	Spliceosome_Homo sapiens_hsa03040	0.69839916
46	Nucleotide excision repair_Homo sapiens_hsa03420	0.69559120
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.68815122
48	Collecting duct acid secretion_Homo sapiens_hsa04966	0.67941815
49	Fatty acid elongation_Homo sapiens_hsa00062	0.67634302
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.65480990
51	Phototransduction_Homo sapiens_hsa04744	0.64585708
52	Nicotine addiction_Homo sapiens_hsa05033	0.60147389
53	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.59790899
54	Retinol metabolism_Homo sapiens_hsa00830	0.59410058
55	Metabolic pathways_Homo sapiens_hsa01100	0.58379339
56	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.57090287
57	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.56412973
58	Fat digestion and absorption_Homo sapiens_hsa04975	0.54774798
59	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.54196224
60	DNA replication_Homo sapiens_hsa03030	0.53088340
61	Sulfur relay system_Homo sapiens_hsa04122	0.52911528
62	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.51946033
63	Steroid biosynthesis_Homo sapiens_hsa00100	0.51147171
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49634287
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.49172008
66	Pyruvate metabolism_Homo sapiens_hsa00620	0.47878625
67	Basal transcription factors_Homo sapiens_hsa03022	0.45500616
68	Viral myocarditis_Homo sapiens_hsa05416	0.45152932
69	Tyrosine metabolism_Homo sapiens_hsa00350	0.43385570
70	Morphine addiction_Homo sapiens_hsa05032	0.43272655
71	Ether lipid metabolism_Homo sapiens_hsa00565	0.42758089
72	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.38671774
73	Selenocompound metabolism_Homo sapiens_hsa00450	0.38516817
74	Non-homologous end-joining_Homo sapiens_hsa03450	0.37411023
75	Fatty acid metabolism_Homo sapiens_hsa01212	0.34309348
76	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.33374659
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.33283848
78	Purine metabolism_Homo sapiens_hsa00230	0.32578419
79	Olfactory transduction_Homo sapiens_hsa04740	0.32491335
80	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.32443423
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.28954939
82	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.28766201
83	Folate biosynthesis_Homo sapiens_hsa00790	0.24885710
84	Caffeine metabolism_Homo sapiens_hsa00232	0.24291487
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.23179906
86	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.22987810
87	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.22920446
88	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.22342828
89	Glutathione metabolism_Homo sapiens_hsa00480	0.22065442
90	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.21464442
91	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.21197353
92	Salmonella infection_Homo sapiens_hsa05132	0.17815308
93	Serotonergic synapse_Homo sapiens_hsa04726	0.17740005
94	Sulfur metabolism_Homo sapiens_hsa00920	0.16275229
95	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.15012868
96	Circadian rhythm_Homo sapiens_hsa04710	0.14514640
97	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.13874555
98	Taste transduction_Homo sapiens_hsa04742	0.13382048
99	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.13204018
100	Phagosome_Homo sapiens_hsa04145	0.12837921

TIMM8BP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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