TIMM9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TIMM9 belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.64910218
2ATP synthesis coupled proton transport (GO:0015986)6.24576752
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.24576752
4DNA deamination (GO:0045006)5.32457370
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.96834493
6respiratory electron transport chain (GO:0022904)4.80723595
7proteasome assembly (GO:0043248)4.72740641
8electron transport chain (GO:0022900)4.69506977
9ribosomal small subunit assembly (GO:0000028)4.63651182
10* chaperone-mediated protein transport (GO:0072321)4.58720216
11mitochondrial respiratory chain complex I assembly (GO:0032981)4.55597671
12NADH dehydrogenase complex assembly (GO:0010257)4.55597671
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.55597671
14protein complex biogenesis (GO:0070271)4.40574621
15protein deneddylation (GO:0000338)4.37137834
16cullin deneddylation (GO:0010388)4.35498006
17viral transcription (GO:0019083)4.30822102
18ribosomal small subunit biogenesis (GO:0042274)4.27825278
19translational termination (GO:0006415)4.27151406
20maturation of SSU-rRNA (GO:0030490)4.27086223
21mitochondrial respiratory chain complex assembly (GO:0033108)4.22634117
22protein complex disassembly (GO:0043241)4.19910083
23regulation of mitochondrial translation (GO:0070129)4.11105774
24oxidative phosphorylation (GO:0006119)4.07211213
25macromolecular complex disassembly (GO:0032984)4.06879079
26L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.99501716
27* establishment of protein localization to mitochondrial membrane (GO:0090151)3.98686702
28chromatin remodeling at centromere (GO:0031055)3.96443043
29translational elongation (GO:0006414)3.90307307
30purine nucleobase biosynthetic process (GO:0009113)3.90191609
31pseudouridine synthesis (GO:0001522)3.87672811
32protein targeting to membrane (GO:0006612)3.86938922
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.84750361
347-methylguanosine mRNA capping (GO:0006370)3.83491354
35SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.82609479
36cotranslational protein targeting to membrane (GO:0006613)3.81185153
37nuclear-transcribed mRNA catabolic process (GO:0000956)3.78524317
38RNA capping (GO:0036260)3.78147086
397-methylguanosine RNA capping (GO:0009452)3.78147086
40* protein targeting to mitochondrion (GO:0006626)3.75442654
41protein targeting to ER (GO:0045047)3.74071323
42ribosomal large subunit biogenesis (GO:0042273)3.72713392
43regulation of cellular amino acid metabolic process (GO:0006521)3.72601807
44nucleobase biosynthetic process (GO:0046112)3.71950434
45termination of RNA polymerase III transcription (GO:0006386)3.71859205
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.71859205
47cellular component biogenesis (GO:0044085)3.67374407
48* establishment of protein localization to mitochondrion (GO:0072655)3.66647896
49establishment of integrated proviral latency (GO:0075713)3.65872745
50ribonucleoprotein complex biogenesis (GO:0022613)3.63843705
51respiratory chain complex IV assembly (GO:0008535)3.62724216
52protein localization to endoplasmic reticulum (GO:0070972)3.61924025
53translation (GO:0006412)3.60626841
54translational initiation (GO:0006413)3.58820155
55negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.57754576
56negative regulation of ligase activity (GO:0051352)3.57754576
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.57368209
58mRNA catabolic process (GO:0006402)3.56561142
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.55725741
60establishment of protein localization to endoplasmic reticulum (GO:0072599)3.54031123
61spliceosomal snRNP assembly (GO:0000387)3.53232236
62* protein localization to mitochondrion (GO:0070585)3.52842141
63regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.49035460
64cellular protein complex disassembly (GO:0043624)3.45893465
65anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.45789652
66guanosine-containing compound biosynthetic process (GO:1901070)3.45421834
67L-methionine salvage (GO:0071267)3.44896975
68L-methionine biosynthetic process (GO:0071265)3.44896975
69amino acid salvage (GO:0043102)3.44896975
70ribosome biogenesis (GO:0042254)3.39569712
71viral life cycle (GO:0019058)3.37524701
72rRNA modification (GO:0000154)3.36829712
73* inner mitochondrial membrane organization (GO:0007007)3.35706909
74protein neddylation (GO:0045116)3.35600970
75quinone biosynthetic process (GO:1901663)3.35566063
76ubiquinone biosynthetic process (GO:0006744)3.35566063
77DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.35263142
78RNA catabolic process (GO:0006401)3.32971610
79metallo-sulfur cluster assembly (GO:0031163)3.32238722
80iron-sulfur cluster assembly (GO:0016226)3.32238722
81ATP biosynthetic process (GO:0006754)3.30491018
82DNA damage response, detection of DNA damage (GO:0042769)3.29899759
83formation of translation preinitiation complex (GO:0001731)3.29717585
84nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.29291156
85purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.28955433
86pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.28532998
87purine nucleoside triphosphate biosynthetic process (GO:0009145)3.28019799
88intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.27898318
89signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.27898318
90rRNA processing (GO:0006364)3.27407134
91spliceosomal complex assembly (GO:0000245)3.26733887
92kinetochore organization (GO:0051383)3.26517866
93aerobic respiration (GO:0009060)3.26411564
94deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.26361144
95transcription elongation from RNA polymerase I promoter (GO:0006362)3.25805097
96signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.23755585
97signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.23755585
98signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.23755585
99GTP biosynthetic process (GO:0006183)3.23580883
100telomere maintenance via semi-conservative replication (GO:0032201)3.21751183
101histone exchange (GO:0043486)3.19645986
102protein-cofactor linkage (GO:0018065)3.18261829
103kinetochore assembly (GO:0051382)3.16347568
104cytochrome complex assembly (GO:0017004)3.15693973
105signal transduction involved in DNA damage checkpoint (GO:0072422)3.13552246
106signal transduction involved in DNA integrity checkpoint (GO:0072401)3.13552246
107CENP-A containing nucleosome assembly (GO:0034080)3.13350530
108rRNA metabolic process (GO:0016072)3.13328022
109maturation of 5.8S rRNA (GO:0000460)3.11660215
110signal transduction involved in cell cycle checkpoint (GO:0072395)3.10711774
111ribosome assembly (GO:0042255)3.10687393
112DNA replication checkpoint (GO:0000076)3.09820393
113* mitochondrial transport (GO:0006839)3.09435344
114ribonucleoside triphosphate biosynthetic process (GO:0009201)3.08392889
115DNA strand elongation involved in DNA replication (GO:0006271)3.08009917
116nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.06259267
117positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.05986036
118tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.01445464
119RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.01445464
120positive regulation of ligase activity (GO:0051351)2.96358222
121pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.95369868
122DNA replication-independent nucleosome organization (GO:0034724)2.95325085

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.89095404
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.58737972
3* GABP_17652178_ChIP-ChIP_JURKAT_Human4.37815412
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.17498971
5* EST1_17652178_ChIP-ChIP_JURKAT_Human4.12839490
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.96406905
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.76398083
8E2F7_22180533_ChIP-Seq_HELA_Human3.62701785
9* HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.51331279
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.49848695
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.40796680
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.32365583
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.26965222
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.26117305
15* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.11597440
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.86008039
17* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.81586284
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.74409829
19* VDR_23849224_ChIP-Seq_CD4+_Human2.66811642
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.61095434
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.55464075
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.48253250
23DCP1A_22483619_ChIP-Seq_HELA_Human2.46860606
24XRN2_22483619_ChIP-Seq_HELA_Human2.39174656
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.37007403
26GABP_19822575_ChIP-Seq_HepG2_Human2.30184113
27* FOXP3_21729870_ChIP-Seq_TREG_Human2.28159508
28* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26678492
29YY1_21170310_ChIP-Seq_MESCs_Mouse2.25896950
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.24517961
31RBPJ_22232070_ChIP-Seq_NCS_Mouse2.18470178
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.17487394
33NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07904020
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07249582
35TTF2_22483619_ChIP-Seq_HELA_Human2.04855684
36* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.04394463
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00864889
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.98720859
39ELK1_19687146_ChIP-ChIP_HELA_Human1.89875290
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75479201
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72830829
42* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.72019678
43* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71391655
44* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69178263
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64496944
46* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59180790
47* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.55293345
48MYC_18940864_ChIP-ChIP_HL60_Human1.54598968
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.54436431
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47143924
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43561034
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41310551
53FOXM1_23109430_ChIP-Seq_U2OS_Human1.39520526
54* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33534258
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31715720
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31639063
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28559343
58BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26274973
59CIITA_25753668_ChIP-Seq_RAJI_Human1.26152980
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.22060297
61AR_21909140_ChIP-Seq_LNCAP_Human1.21187378
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20968936
63KDM5A_27292631_Chip-Seq_BREAST_Human1.19593062
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19429115
65IRF1_19129219_ChIP-ChIP_H3396_Human1.19398582
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12284490
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.11092582
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09591800
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.09215841
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09123448
71IGF1R_20145208_ChIP-Seq_DFB_Human1.08207458
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08122831
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07499645
74SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06454347
75* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06425768
76CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04654525
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00003121
78* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99894283
79VDR_22108803_ChIP-Seq_LS180_Human0.99819877
80* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96093667
81ZNF274_21170338_ChIP-Seq_K562_Hela0.93532218
82NANOG_16153702_ChIP-ChIP_HESCs_Human0.92437825
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91920827
84SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89939090
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89160238
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88779803
87* SOX2_16153702_ChIP-ChIP_HESCs_Human0.86232838
88SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82940133
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82079212
90TP63_19390658_ChIP-ChIP_HaCaT_Human0.77900305
91* TP53_22573176_ChIP-Seq_HFKS_Human0.75777616
92EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.75626592
93TAF15_26573619_Chip-Seq_HEK293_Human0.75100172
94POU5F1_16153702_ChIP-ChIP_HESCs_Human0.75077713
95TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.74479288
96TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74413002
97* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.73884044
98ELF5_23300383_ChIP-Seq_T47D_Human0.73448243
99SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.71710694
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.70036527
101FUS_26573619_Chip-Seq_HEK293_Human0.69427914
102* SOX17_20123909_ChIP-Seq_XEN_Mouse0.68974449
103* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.67791555
104FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.67783878
105HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.67069213
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.65946357
107CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.65708639
108EWS_26573619_Chip-Seq_HEK293_Human0.64107452
109TFEB_21752829_ChIP-Seq_HELA_Human0.64062638
110STAT3_1855785_ChIP-Seq_MESCs_Mouse0.63341705
111SRY_22984422_ChIP-ChIP_TESTIS_Rat0.62897569
112PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.61799049
113KLF4_18555785_ChIP-Seq_MESCs_Mouse0.61077064
114HTT_18923047_ChIP-ChIP_STHdh_Human0.60874397
115* FOXP1_21924763_ChIP-Seq_HESCs_Human0.60274525

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.79730151
2MP0003806_abnormal_nucleotide_metabolis3.34561622
3MP0001529_abnormal_vocalization3.30417117
4MP0006036_abnormal_mitochondrial_physio3.16615919
5MP0008995_early_reproductive_senescence3.10244055
6MP0004957_abnormal_blastocyst_morpholog3.04868118
7MP0006035_abnormal_mitochondrial_morpho2.79668951
8MP0003880_abnormal_central_pattern2.79389908
9MP0009379_abnormal_foot_pigmentation2.68046240
10MP0003718_maternal_effect2.58402067
11MP0010094_abnormal_chromosome_stability2.51355826
12MP0006276_abnormal_autonomic_nervous2.31680404
13MP0003646_muscle_fatigue2.24451297
14MP0004147_increased_porphyrin_level2.22944636
15MP0008057_abnormal_DNA_replication2.20378627
16MP0008058_abnormal_DNA_repair2.15681847
17MP0008877_abnormal_DNA_methylation2.05435706
18MP0001905_abnormal_dopamine_level2.00598677
19MP0003111_abnormal_nucleus_morphology1.98486479
20MP0006292_abnormal_olfactory_placode1.98043189
21MP0006072_abnormal_retinal_apoptosis1.97265743
22MP0002736_abnormal_nociception_after1.96479742
23MP0004142_abnormal_muscle_tone1.95815686
24MP0003077_abnormal_cell_cycle1.95602818
25MP0008932_abnormal_embryonic_tissue1.92172849
26MP0003186_abnormal_redox_activity1.88985065
27MP0002638_abnormal_pupillary_reflex1.84666420
28MP0001968_abnormal_touch/_nociception1.77499824
29MP0003123_paternal_imprinting1.74027408
30MP0009697_abnormal_copulation1.72954246
31MP0002837_dystrophic_cardiac_calcinosis1.62345597
32MP0003786_premature_aging1.61341466
33MP0001764_abnormal_homeostasis1.59043872
34MP0001293_anophthalmia1.58105392
35MP0008875_abnormal_xenobiotic_pharmacok1.57522646
36MP0003656_abnormal_erythrocyte_physiolo1.56551813
37MP0003567_abnormal_fetal_cardiomyocyte1.34779965
38MP0002132_abnormal_respiratory_system1.34699124
39MP0002139_abnormal_hepatobiliary_system1.30318157
40MP0002876_abnormal_thyroid_physiology1.28744358
41MP0000358_abnormal_cell_content/1.26659191
42MP0001188_hyperpigmentation1.25557001
43MP0005085_abnormal_gallbladder_physiolo1.25174521
44MP0009745_abnormal_behavioral_response1.25031814
45MP0005360_urolithiasis1.24371842
46MP0001984_abnormal_olfaction1.23320187
47MP0002735_abnormal_chemical_nociception1.22480701
48MP0001986_abnormal_taste_sensitivity1.21942252
49MP0002102_abnormal_ear_morphology1.20222261
50MP0005365_abnormal_bile_salt1.19961178
51MP0008872_abnormal_physiological_respon1.19401547
52MP0003941_abnormal_skin_development1.18094660
53MP0008260_abnormal_autophagy1.17711427
54MP0002396_abnormal_hematopoietic_system1.17619271
55MP0000049_abnormal_middle_ear1.17444066
56MP0005646_abnormal_pituitary_gland1.17182845
57MP0002822_catalepsy1.15905103
58MP0002277_abnormal_respiratory_mucosa1.14246240
59MP0008789_abnormal_olfactory_epithelium1.12392403
60MP0009046_muscle_twitch1.12272791
61MP0010030_abnormal_orbit_morphology1.12196327
62MP0002272_abnormal_nervous_system1.11838937
63MP0005636_abnormal_mineral_homeostasis1.07617535
64MP0008007_abnormal_cellular_replicative1.07464350
65MP0005075_abnormal_melanosome_morpholog1.07300127
66MP0001697_abnormal_embryo_size1.06937925
67MP0004215_abnormal_myocardial_fiber1.06738284
68MP0002234_abnormal_pharynx_morphology1.04447708
69MP0005266_abnormal_metabolism1.01693083
70MP0002572_abnormal_emotion/affect_behav1.01503588
71MP0003635_abnormal_synaptic_transmissio1.00952389
72MP0001440_abnormal_grooming_behavior0.99629774
73MP0001485_abnormal_pinna_reflex0.99099564
74MP0002163_abnormal_gland_morphology0.98491684
75MP0002734_abnormal_mechanical_nocicepti0.96506821
76MP0002064_seizures0.95099414
77MP0005389_reproductive_system_phenotype0.93243772
78MP0003937_abnormal_limbs/digits/tail_de0.92796775
79MP0003121_genomic_imprinting0.91576528
80MP0005332_abnormal_amino_acid0.90617586
81MP0005386_behavior/neurological_phenoty0.89943209
82MP0004924_abnormal_behavior0.89943209
83MP0004859_abnormal_synaptic_plasticity0.89792395
84MP0005379_endocrine/exocrine_gland_phen0.89687299
85MP0005499_abnormal_olfactory_system0.88789965
86MP0005394_taste/olfaction_phenotype0.88789965
87MP0003221_abnormal_cardiomyocyte_apopto0.88565624
88MP0001730_embryonic_growth_arrest0.88502294
89MP0002063_abnormal_learning/memory/cond0.87689800
90MP0009333_abnormal_splenocyte_physiolog0.87272615
91MP0001727_abnormal_embryo_implantation0.87225123
92MP0001929_abnormal_gametogenesis0.87035154
93MP0001119_abnormal_female_reproductive0.85884151
94MP0001501_abnormal_sleep_pattern0.85832945
95MP0000749_muscle_degeneration0.85591110
96MP0001881_abnormal_mammary_gland0.84682970
97MP0002160_abnormal_reproductive_system0.83768733
98MP0001970_abnormal_pain_threshold0.83110527
99MP0002210_abnormal_sex_determination0.82796966
100MP0001286_abnormal_eye_development0.82395830
101MP0002067_abnormal_sensory_capabilities0.82092020
102MP0000372_irregular_coat_pigmentation0.81580973
103MP0001672_abnormal_embryogenesis/_devel0.80385091
104MP0005380_embryogenesis_phenotype0.80385091
105MP0002733_abnormal_thermal_nociception0.80057695
106MP0002938_white_spotting0.79842641
107MP0000653_abnormal_sex_gland0.77978668
108MP0002080_prenatal_lethality0.77478336
109MP0005084_abnormal_gallbladder_morpholo0.76409107
110MP0005253_abnormal_eye_physiology0.76364084
111MP0009250_abnormal_appendicular_skeleto0.75819381
112MP0000631_abnormal_neuroendocrine_gland0.75414434
113MP0002233_abnormal_nose_morphology0.74999130
114MP0002697_abnormal_eye_size0.74924923
115MP0003698_abnormal_male_reproductive0.74575467
116MP0000313_abnormal_cell_death0.74163660
117MP0002095_abnormal_skin_pigmentation0.73999542
118MP0002085_abnormal_embryonic_tissue0.73728209
119MP0003122_maternal_imprinting0.73042968
120MP0002653_abnormal_ependyma_morphology0.72306430
121MP0005408_hypopigmentation0.72017397
122MP0002090_abnormal_vision0.71586579
123MP0004145_abnormal_muscle_electrophysio0.71230458
124MP0010386_abnormal_urinary_bladder0.70956800
125MP0005376_homeostasis/metabolism_phenot0.70234502
126MP0001145_abnormal_male_reproductive0.69831360
127MP0000350_abnormal_cell_proliferation0.68832702
128MP0002019_abnormal_tumor_incidence0.67294739
129MP0002088_abnormal_embryonic_growth/wei0.67022469
130MP0003315_abnormal_perineum_morphology0.66757773
131MP0003984_embryonic_growth_retardation0.66265151
132MP0003787_abnormal_imprinting0.64137435
133MP0005501_abnormal_skin_physiology0.61876946
134MP0002177_abnormal_outer_ear0.61129591
135MP0000647_abnormal_sebaceous_gland0.60449721
136MP0002161_abnormal_fertility/fecundity0.60331764
137MP0003136_yellow_coat_color0.60078402
138MP0002084_abnormal_developmental_patter0.59407299
139MP0003936_abnormal_reproductive_system0.58914625

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.98614010
2Abnormal mitochondria in muscle tissue (HP:0008316)5.65413952
3Mitochondrial inheritance (HP:0001427)5.50871926
4Acute encephalopathy (HP:0006846)5.19555772
5Hepatocellular necrosis (HP:0001404)5.16572917
6Increased CSF lactate (HP:0002490)5.11006934
7Progressive macrocephaly (HP:0004481)4.86284590
8Hepatic necrosis (HP:0002605)4.70200539
9Abnormality of cells of the erythroid lineage (HP:0012130)4.50910302
10Increased serum pyruvate (HP:0003542)4.48436391
11Abnormality of glycolysis (HP:0004366)4.48436391
12Increased hepatocellular lipid droplets (HP:0006565)4.45875851
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.42793271
14Decreased activity of mitochondrial respiratory chain (HP:0008972)4.42793271
15Abnormal number of erythroid precursors (HP:0012131)4.42726044
16Lipid accumulation in hepatocytes (HP:0006561)4.10319903
17Increased serum lactate (HP:0002151)3.97618369
183-Methylglutaconic aciduria (HP:0003535)3.89516413
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.88172177
20Birth length less than 3rd percentile (HP:0003561)3.87471618
21Lactic acidosis (HP:0003128)3.86153980
22Cerebral edema (HP:0002181)3.84969521
23Increased intramyocellular lipid droplets (HP:0012240)3.75728226
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.64090268
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.61823043
26Renal Fanconi syndrome (HP:0001994)3.54505969
27Abnormality of alanine metabolism (HP:0010916)3.52305270
28Hyperalaninemia (HP:0003348)3.52305270
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.52305270
30Exercise intolerance (HP:0003546)3.45845180
31Aplastic anemia (HP:0001915)3.39594904
32Chromsome breakage (HP:0040012)3.38726217
33Respiratory failure (HP:0002878)3.32482499
34Increased muscle lipid content (HP:0009058)3.23157770
35Oral leukoplakia (HP:0002745)3.10317333
36Respiratory difficulties (HP:0002880)2.95721949
37Leukodystrophy (HP:0002415)2.93468111
38CNS demyelination (HP:0007305)2.93097943
39Exertional dyspnea (HP:0002875)2.90161788
40Optic disc pallor (HP:0000543)2.85812909
41Macrocytic anemia (HP:0001972)2.82483835
42Reticulocytopenia (HP:0001896)2.80073877
43Abnormality of the renal collecting system (HP:0004742)2.78046457
44Absent thumb (HP:0009777)2.77006622
45Microvesicular hepatic steatosis (HP:0001414)2.74937553
46Meckel diverticulum (HP:0002245)2.74819841
47Abnormality of the heme biosynthetic pathway (HP:0010472)2.74382940
48Duplicated collecting system (HP:0000081)2.71939448
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.63426456
50Cerebral hypomyelination (HP:0006808)2.61785277
51Abnormality of the ileum (HP:0001549)2.60087654
52Abnormality of the preputium (HP:0100587)2.59832322
53Emotional lability (HP:0000712)2.53615218
54Pallor (HP:0000980)2.49214037
55Lethargy (HP:0001254)2.48054662
56Aplasia/Hypoplasia of the sacrum (HP:0008517)2.45608729
57Poor suck (HP:0002033)2.36632744
58Abnormality of chromosome stability (HP:0003220)2.30250557
59Breast hypoplasia (HP:0003187)2.29059412
60Ragged-red muscle fibers (HP:0003200)2.28474793
61Abnormality of methionine metabolism (HP:0010901)2.27718553
62Triphalangeal thumb (HP:0001199)2.25379699
63Abnormality of DNA repair (HP:0003254)2.21010443
64Microretrognathia (HP:0000308)2.19425904
65Abnormality of renal resorption (HP:0011038)2.18295071
66Methylmalonic acidemia (HP:0002912)2.16346434
67Unsteady gait (HP:0002317)2.16027360
68Type 2 muscle fiber atrophy (HP:0003554)2.15406095
69Glycosuria (HP:0003076)2.15010364
70Abnormality of urine glucose concentration (HP:0011016)2.15010364
71Stenosis of the external auditory canal (HP:0000402)2.12099711
72Neuroendocrine neoplasm (HP:0100634)2.10548352
73Gliosis (HP:0002171)2.09418937
74Colon cancer (HP:0003003)2.08996162
75Abnormal protein glycosylation (HP:0012346)2.06513157
76Abnormal glycosylation (HP:0012345)2.06513157
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06513157
78Abnormal protein N-linked glycosylation (HP:0012347)2.06513157
79Type I transferrin isoform profile (HP:0003642)2.04252351
80Degeneration of anterior horn cells (HP:0002398)2.03705771
81Abnormality of the anterior horn cell (HP:0006802)2.03705771
82Delusions (HP:0000746)2.02785552
83Abnormality of serum amino acid levels (HP:0003112)1.99571742
84Brushfield spots (HP:0001088)1.98430739
85CNS hypomyelination (HP:0003429)1.97710194
86Pheochromocytoma (HP:0002666)1.97207830
87Ectopic kidney (HP:0000086)1.96648676
88Duodenal stenosis (HP:0100867)1.96630524
89Small intestinal stenosis (HP:0012848)1.96630524
90Rough bone trabeculation (HP:0100670)1.96466331
91Muscle fiber atrophy (HP:0100295)1.95563099
92Methylmalonic aciduria (HP:0012120)1.95106728
93Hypobetalipoproteinemia (HP:0003563)1.94638627
94Progressive external ophthalmoplegia (HP:0000590)1.94556211
95Pancytopenia (HP:0001876)1.92619009
96Abnormality of aromatic amino acid family metabolism (HP:0004338)1.89735481
97Hyperphosphaturia (HP:0003109)1.86662114
98X-linked dominant inheritance (HP:0001423)1.85174502
99Duplication of thumb phalanx (HP:0009942)1.84950664
100Multiple enchondromatosis (HP:0005701)1.82419706
101Focal motor seizures (HP:0011153)1.81819788
102Postnatal microcephaly (HP:0005484)1.79004790
103Reduced antithrombin III activity (HP:0001976)1.78386460
104Dicarboxylic aciduria (HP:0003215)1.78151036
105Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78151036
106Amniotic constriction ring (HP:0009775)1.77626672
107Abnormality of placental membranes (HP:0011409)1.77626672
108Abnormality of aspartate family amino acid metabolism (HP:0010899)1.75234538
109Myelodysplasia (HP:0002863)1.73990521
110Abnormality of the duodenum (HP:0002246)1.73330135
111Abnormality of reticulocytes (HP:0004312)1.72852108
112Generalized aminoaciduria (HP:0002909)1.71783976
113Congenital, generalized hypertrichosis (HP:0004540)1.71304216
114Female pseudohermaphroditism (HP:0010458)1.69269466
115Cleft eyelid (HP:0000625)1.67652143
116Abnormal lung lobation (HP:0002101)1.67273462
117Hyperglycinemia (HP:0002154)1.67054010
118Megaloblastic anemia (HP:0001889)1.64584844
119Abnormality of pyrimidine metabolism (HP:0004353)1.64208338
120Short thumb (HP:0009778)1.62611099
121Abnormal pupillary function (HP:0007686)1.62562762
122Abnormality of the labia minora (HP:0012880)1.62375055
123Myokymia (HP:0002411)1.62215127
124Nausea (HP:0002018)1.62144642
125Neutropenia (HP:0001875)1.61806772
126Progressive muscle weakness (HP:0003323)1.61765367
127Cellular immunodeficiency (HP:0005374)1.61742593
128Premature ovarian failure (HP:0008209)1.61428564
129Atrophy/Degeneration involving motor neurons (HP:0007373)1.61152673
130Carpal bone hypoplasia (HP:0001498)1.60963432
131Abnormality of fatty-acid metabolism (HP:0004359)1.60657867
132Medial flaring of the eyebrow (HP:0010747)1.59188587
133Vomiting (HP:0002013)1.59183012
134Secondary amenorrhea (HP:0000869)1.59082365
135Gait imbalance (HP:0002141)1.58486184
136Metabolic acidosis (HP:0001942)1.57237079
137Palpitations (HP:0001962)1.56621012
138Horseshoe kidney (HP:0000085)1.55181026

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.31274425
2VRK24.06801547
3MAP3K123.67913336
4NME23.60243448
5PBK3.40892690
6TAOK33.06699037
7BUB13.06493497
8WEE12.88860830
9EIF2AK12.83232551
10VRK12.40661594
11SRPK12.28891048
12TSSK62.28886888
13NME12.28589612
14CDK192.13155628
15EIF2AK32.07054138
16MAP2K72.01711619
17CDC71.99925520
18BRAF1.90129128
19ACVR1B1.89905627
20ARAF1.86935392
21ZAK1.83460485
22CDK81.69628580
23TAF11.68529568
24MAP3K61.61584800
25LIMK11.51003508
26CCNB11.45322775
27PIM21.43829430
28MUSK1.41397261
29MAP3K41.39433620
30NUAK11.37729980
31MKNK11.31102228
32TXK1.31093703
33DAPK11.29374476
34PLK41.28162842
35NEK11.27557138
36BCKDK1.26638803
37MAP2K41.22512958
38TNIK1.22105184
39MAP4K21.16636397
40AURKA1.15648157
41BRSK21.14064417
42PLK11.13764832
43DYRK31.13550427
44TESK21.11120513
45TRIM281.09948008
46DYRK21.07863471
47MAP3K111.06005109
48PLK31.03269300
49MYLK1.03236968
50CASK1.03235534
51PDK21.03084572
52PDK30.97204885
53PDK40.97204885
54SCYL20.97179903
55TTK0.93950669
56MKNK20.93448637
57RPS6KA40.91918821
58MOS0.91158510
59PNCK0.90321022
60ABL20.90091133
61ERBB30.89420028
62NTRK30.87149161
63TLK10.85253025
64EPHA40.84051573
65WNK30.83997281
66BMPR1B0.83669923
67BRSK10.80241927
68MAPK130.78759414
69CHEK20.78504634
70AURKB0.77469468
71CSNK1G20.75985367
72TESK10.74914981
73MINK10.73963291
74CSNK2A20.72826916
75CSNK2A10.70115700
76CDK70.69096854
77OXSR10.68518986
78RAF10.68027816
79ATR0.66218239
80CSNK1G30.66062882
81GRK50.65580050
82ERBB40.64562519
83BMPR20.64296785
84MAP4K10.63980545
85RPS6KA50.63509184
86CSNK1A1L0.61858463
87ADRBK20.61799988
88MST40.59560231
89CHEK10.58812936
90OBSCN0.58770332
91MARK10.58675721
92RPS6KB20.57026205
93ATM0.56617683
94EIF2AK20.56607196
95MAP3K50.56504328
96KDR0.55676801
97GRK10.55012095
98PRKCG0.54841663
99NEK20.52397657
100STK240.51624778
101INSRR0.51359200
102DAPK30.50209907
103TNK20.50196155
104PAK10.49984097
105STK30.48701743
106PLK20.47675000
107GRK70.47273541
108STK40.47205366
109PINK10.44632863
110TEC0.43752656
111CDK30.43548281
112TGFBR10.43188731
113TAOK20.42987734
114ILK0.39028615
115MAP2K60.38971365
116MAPKAPK50.36429742
117PASK0.35949359
118CDK180.35073366
119ADRBK10.34227975
120CAMK2A0.34028388
121CAMK2B0.33460190
122BCR0.32686630
123MAPK40.32569811
124CSNK1E0.32359594
125CSNK1G10.31883071
126CDK11A0.31676141
127AKT30.31493130
128CAMK2G0.30459709
129CSNK1A10.30433408
130CDK150.30375900
131PAK40.29280832
132PRKCI0.29077911
133CDK10.28922399
134FLT30.27013554
135STK38L0.25904839
136CLK10.25883409
137CDK20.25724555

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.27151143
2Ribosome_Homo sapiens_hsa030104.21058494
3Proteasome_Homo sapiens_hsa030504.15878913
4Parkinsons disease_Homo sapiens_hsa050123.78437116
5RNA polymerase_Homo sapiens_hsa030203.46633914
6DNA replication_Homo sapiens_hsa030302.87449668
7Huntingtons disease_Homo sapiens_hsa050162.84063721
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.63164052
9Alzheimers disease_Homo sapiens_hsa050102.53614819
10Mismatch repair_Homo sapiens_hsa034302.36667984
11Pyrimidine metabolism_Homo sapiens_hsa002402.35303319
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.33548395
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.10552772
14Spliceosome_Homo sapiens_hsa030402.08705375
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.99454532
16Nucleotide excision repair_Homo sapiens_hsa034201.98145155
17Protein export_Homo sapiens_hsa030601.94946306
18RNA transport_Homo sapiens_hsa030131.84793170
19Homologous recombination_Homo sapiens_hsa034401.82294027
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.66599304
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62592230
22Base excision repair_Homo sapiens_hsa034101.60215058
23Basal transcription factors_Homo sapiens_hsa030221.59502041
24Purine metabolism_Homo sapiens_hsa002301.42792181
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41782043
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38159784
27Cardiac muscle contraction_Homo sapiens_hsa042601.37812264
28Pyruvate metabolism_Homo sapiens_hsa006201.35144403
29Vitamin B6 metabolism_Homo sapiens_hsa007501.30658321
30RNA degradation_Homo sapiens_hsa030181.30426954
31One carbon pool by folate_Homo sapiens_hsa006701.25391821
32Sulfur relay system_Homo sapiens_hsa041221.22297708
33Folate biosynthesis_Homo sapiens_hsa007901.21734010
34Carbon metabolism_Homo sapiens_hsa012001.18511483
35Non-homologous end-joining_Homo sapiens_hsa034501.13577695
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.11929864
37Propanoate metabolism_Homo sapiens_hsa006401.10599715
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.08332738
39Collecting duct acid secretion_Homo sapiens_hsa049661.06608414
40Biosynthesis of amino acids_Homo sapiens_hsa012301.01008327
41Fanconi anemia pathway_Homo sapiens_hsa034601.00773570
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00214471
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95791060
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95600116
45Cell cycle_Homo sapiens_hsa041100.94398005
46Fatty acid elongation_Homo sapiens_hsa000620.93105927
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91795739
48Metabolic pathways_Homo sapiens_hsa011000.90428075
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.80719940
50Pentose phosphate pathway_Homo sapiens_hsa000300.78742554
51Nicotine addiction_Homo sapiens_hsa050330.75989699
52Peroxisome_Homo sapiens_hsa041460.75625915
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74320647
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72855409
55Steroid biosynthesis_Homo sapiens_hsa001000.71339505
56Glutathione metabolism_Homo sapiens_hsa004800.70919858
57Butanoate metabolism_Homo sapiens_hsa006500.69028402
58Vibrio cholerae infection_Homo sapiens_hsa051100.65344609
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62727114
60Tyrosine metabolism_Homo sapiens_hsa003500.62377652
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61455685
62Phenylalanine metabolism_Homo sapiens_hsa003600.60771699
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58823029
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58329050
65Regulation of autophagy_Homo sapiens_hsa041400.58309892
66Asthma_Homo sapiens_hsa053100.58190115
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56136424
68Synaptic vesicle cycle_Homo sapiens_hsa047210.55097416
69beta-Alanine metabolism_Homo sapiens_hsa004100.54179234
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51578758
71mRNA surveillance pathway_Homo sapiens_hsa030150.49036716
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48766188
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48553569
74Epstein-Barr virus infection_Homo sapiens_hsa051690.46274992
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45885101
76Selenocompound metabolism_Homo sapiens_hsa004500.44532241
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.42590889
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40861786
79Oocyte meiosis_Homo sapiens_hsa041140.40212981
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39296948
81Arginine and proline metabolism_Homo sapiens_hsa003300.38451942
82Sulfur metabolism_Homo sapiens_hsa009200.37776714
83N-Glycan biosynthesis_Homo sapiens_hsa005100.34312236
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33149775
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30574941
86Galactose metabolism_Homo sapiens_hsa000520.29720575
87Fructose and mannose metabolism_Homo sapiens_hsa000510.28407196
88Vitamin digestion and absorption_Homo sapiens_hsa049770.28367317
89Chemical carcinogenesis_Homo sapiens_hsa052040.27598375
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27260002
91p53 signaling pathway_Homo sapiens_hsa041150.25445609
92Phototransduction_Homo sapiens_hsa047440.24302202
93Histidine metabolism_Homo sapiens_hsa003400.23796474
94Fatty acid degradation_Homo sapiens_hsa000710.23114950
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23028594
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.22948496
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.19942651
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19409415
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19066008
100Tryptophan metabolism_Homo sapiens_hsa003800.18163843
101Taste transduction_Homo sapiens_hsa047420.17895877
102Linoleic acid metabolism_Homo sapiens_hsa005910.17173035
103Serotonergic synapse_Homo sapiens_hsa047260.16338752
104Arachidonic acid metabolism_Homo sapiens_hsa005900.16162031
105Systemic lupus erythematosus_Homo sapiens_hsa053220.15670509
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.14292009
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.13693488
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.12686758
109Fatty acid metabolism_Homo sapiens_hsa012120.11249839
110Retinol metabolism_Homo sapiens_hsa008300.10416568
111Caffeine metabolism_Homo sapiens_hsa002320.10269293
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.10092375
113Allograft rejection_Homo sapiens_hsa053300.08325674
114Autoimmune thyroid disease_Homo sapiens_hsa053200.07293220
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.06721071
116Alcoholism_Homo sapiens_hsa050340.04232448

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