TIMMDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.12757826
2chaperone-mediated protein transport (GO:0072321)5.33372548
3establishment of protein localization to mitochondrial membrane (GO:0090151)5.30646026
4ATP synthesis coupled proton transport (GO:0015986)5.13748946
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.13748946
6negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.65345548
7positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.41842045
8regulation of cellular amino acid metabolic process (GO:0006521)4.36690925
9regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.34936613
10indole-containing compound catabolic process (GO:0042436)4.27172899
11indolalkylamine catabolic process (GO:0046218)4.27172899
12tryptophan catabolic process (GO:0006569)4.27172899
13negative regulation of ligase activity (GO:0051352)4.23978008
14negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.23978008
15rRNA modification (GO:0000154)4.17949881
16tryptophan metabolic process (GO:0006568)4.13973818
17aromatic amino acid family catabolic process (GO:0009074)4.08233560
18anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.05175511
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.03612428
20L-phenylalanine metabolic process (GO:0006558)4.03612428
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.94173820
22L-phenylalanine catabolic process (GO:0006559)3.94173820
23protein targeting to mitochondrion (GO:0006626)3.89225904
24DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.86524749
25protein deneddylation (GO:0000338)3.80684751
26kynurenine metabolic process (GO:0070189)3.79969162
27signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.79569242
28signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.79569242
29signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.79569242
30establishment of integrated proviral latency (GO:0075713)3.78682032
31intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.78032674
32signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.78032674
33positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.77758813
34cullin deneddylation (GO:0010388)3.75997024
35inner mitochondrial membrane organization (GO:0007007)3.70280438
36ribosomal small subunit assembly (GO:0000028)3.69655431
37signal transduction involved in DNA integrity checkpoint (GO:0072401)3.67810989
38signal transduction involved in DNA damage checkpoint (GO:0072422)3.67810989
39ribosomal large subunit biogenesis (GO:0042273)3.66041506
40protein localization to mitochondrion (GO:0070585)3.64398321
41establishment of protein localization to mitochondrion (GO:0072655)3.62903622
42NAD biosynthetic process (GO:0009435)3.62563207
43proteasome assembly (GO:0043248)3.61785986
44positive regulation of ligase activity (GO:0051351)3.61686114
45ribosome assembly (GO:0042255)3.61260145
46ubiquinone biosynthetic process (GO:0006744)3.59725389
47quinone biosynthetic process (GO:1901663)3.59725389
48signal transduction involved in cell cycle checkpoint (GO:0072395)3.59247031
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.58308741
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.58308741
51protein complex biogenesis (GO:0070271)3.51128979
52branched-chain amino acid catabolic process (GO:0009083)3.49438508
53ubiquinone metabolic process (GO:0006743)3.49177315
54amine catabolic process (GO:0009310)3.47261842
55cellular biogenic amine catabolic process (GO:0042402)3.47261842
56glyoxylate metabolic process (GO:0046487)3.45599751
57protein neddylation (GO:0045116)3.45381638
58rRNA methylation (GO:0031167)3.44549362
59aldehyde catabolic process (GO:0046185)3.41650934
60tricarboxylic acid cycle (GO:0006099)3.39635713
61purine nucleobase biosynthetic process (GO:0009113)3.37977558
62respiratory chain complex IV assembly (GO:0008535)3.36298703
63regulation of ubiquitin-protein transferase activity (GO:0051438)3.35866929
64pseudouridine synthesis (GO:0001522)3.35235587
65regulation of mitochondrial translation (GO:0070129)3.33766174
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.33647868
67mitochondrial respiratory chain complex I assembly (GO:0032981)3.33647868
68NADH dehydrogenase complex assembly (GO:0010257)3.33647868
69translation (GO:0006412)3.31700865
70tRNA methylation (GO:0030488)3.26859779
71heart contraction (GO:0060047)3.26601038
72heart process (GO:0003015)3.26601038
73establishment of viral latency (GO:0019043)3.25457609
74indolalkylamine metabolic process (GO:0006586)3.24441655
75regulation of ligase activity (GO:0051340)3.24155189
76cytochrome complex assembly (GO:0017004)3.23890784
77mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.23588669
78mitochondrial transport (GO:0006839)3.20236211
79cellular component biogenesis (GO:0044085)3.19872565
80aromatic amino acid family metabolic process (GO:0009072)3.19331267
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.18087988
82regulation of cellular amine metabolic process (GO:0033238)3.14720008
83maturation of SSU-rRNA (GO:0030490)3.13748399
84bile acid biosynthetic process (GO:0006699)3.12916106
85water-soluble vitamin biosynthetic process (GO:0042364)3.11613754
86imidazole-containing compound metabolic process (GO:0052803)3.10678540
87SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.07889923
88spliceosomal snRNP assembly (GO:0000387)3.07195475
89mitochondrial respiratory chain complex assembly (GO:0033108)3.07102171
90cotranslational protein targeting to membrane (GO:0006613)3.05997152
91serine family amino acid biosynthetic process (GO:0009070)3.05448244
92protein maturation by protein folding (GO:0022417)3.05130571
93oxidative phosphorylation (GO:0006119)3.04748311
94nucleobase biosynthetic process (GO:0046112)3.03395188
95amino acid salvage (GO:0043102)3.02799059
96L-methionine salvage (GO:0071267)3.02799059
97L-methionine biosynthetic process (GO:0071265)3.02799059
98polyketide metabolic process (GO:0030638)3.02325985
99doxorubicin metabolic process (GO:0044598)3.02325985
100daunorubicin metabolic process (GO:0044597)3.02325985
101protein targeting to ER (GO:0045047)3.02041188
102pyridine nucleotide biosynthetic process (GO:0019363)3.01183915
103nicotinamide nucleotide biosynthetic process (GO:0019359)3.01183915
104regulation of cholesterol esterification (GO:0010872)3.00810325
105amino-acid betaine metabolic process (GO:0006577)3.00395576
106iron-sulfur cluster assembly (GO:0016226)3.00059273
107metallo-sulfur cluster assembly (GO:0031163)3.00059273
108glycine metabolic process (GO:0006544)2.99615449
109DNA deamination (GO:0045006)2.97472850
110CENP-A containing nucleosome assembly (GO:0034080)2.96537783
111ribosomal small subunit biogenesis (GO:0042274)2.96387770
112cellular glucuronidation (GO:0052695)2.96211718
113branched-chain amino acid metabolic process (GO:0009081)2.95823809
114exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.95794779
115negative regulation of protein ubiquitination (GO:0031397)2.95222384
116establishment of protein localization to endoplasmic reticulum (GO:0072599)2.94782519
117formation of translation preinitiation complex (GO:0001731)2.94673078
118nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.94018690
119protein localization to endoplasmic reticulum (GO:0070972)2.93986665
120antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.93864839
121hydrogen ion transmembrane transport (GO:1902600)2.91775905
122ATP biosynthetic process (GO:0006754)2.90951856
123rRNA processing (GO:0006364)2.90610313
124maturation of 5.8S rRNA (GO:0000460)2.90226288
125purine nucleoside triphosphate biosynthetic process (GO:0009145)2.89530113
126deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.89143138
127tRNA aminoacylation for protein translation (GO:0006418)2.88944557
128cellular respiration (GO:0045333)2.88682008
129respiratory electron transport chain (GO:0022904)2.88201517
130tRNA aminoacylation (GO:0043039)2.87151699
131amino acid activation (GO:0043038)2.87151699
132ribonucleoprotein complex biogenesis (GO:0022613)2.87145892
133DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.85445082
134chromatin remodeling at centromere (GO:0031055)2.85118066
135quinone metabolic process (GO:1901661)2.85095668
136serine family amino acid catabolic process (GO:0009071)2.84776274
137positive regulation of cell cycle arrest (GO:0071158)2.84451330
138intracellular protein transmembrane import (GO:0044743)2.83132730
139NAD metabolic process (GO:0019674)2.82289927
140omega-hydroxylase P450 pathway (GO:0097267)2.78634520
141uronic acid metabolic process (GO:0006063)2.78118428
142glucuronate metabolic process (GO:0019585)2.78118428
143electron transport chain (GO:0022900)2.76622571
144transcription elongation from RNA polymerase III promoter (GO:0006385)2.76578620
145termination of RNA polymerase III transcription (GO:0006386)2.76578620
146coenzyme catabolic process (GO:0009109)2.76531469
1472-deoxyribonucleotide biosynthetic process (GO:0009265)2.75957048
148deoxyribose phosphate biosynthetic process (GO:0046385)2.75957048
149fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.75792057
150response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.75234194
151tyrosine metabolic process (GO:0006570)2.74633432
152alpha-amino acid catabolic process (GO:1901606)2.74134231
153fatty acid beta-oxidation (GO:0006635)2.73641753
154signal peptide processing (GO:0006465)2.72931567
155serine family amino acid metabolic process (GO:0009069)2.72371479
156triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.70902075
157response to nitrosative stress (GO:0051409)2.70837784
158L-serine metabolic process (GO:0006563)2.70808478
159L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.70201511
160carnitine metabolic process (GO:0009437)2.68157436
161nucleotide transmembrane transport (GO:1901679)2.66671139
162cofactor catabolic process (GO:0051187)2.66546319
163methionine metabolic process (GO:0006555)2.63969012
164low-density lipoprotein particle remodeling (GO:0034374)2.63689416
165pyrimidine nucleoside catabolic process (GO:0046135)2.62713626
166methionine biosynthetic process (GO:0009086)2.57325420
167peptidyl-glutamic acid carboxylation (GO:0017187)2.54283287
168protein carboxylation (GO:0018214)2.54283287
169carboxylic acid catabolic process (GO:0046395)2.53317824
170organic acid catabolic process (GO:0016054)2.53317824
171aerobic respiration (GO:0009060)2.52762974
172high-density lipoprotein particle remodeling (GO:0034375)2.52369276
173actin-myosin filament sliding (GO:0033275)2.52151927
174muscle filament sliding (GO:0030049)2.52151927
175bile acid metabolic process (GO:0008206)2.50550122
176cellular amino acid catabolic process (GO:0009063)2.50023243
177sulfur amino acid biosynthetic process (GO:0000097)2.49661335
178fatty acid catabolic process (GO:0009062)2.49633656
179adenosine metabolic process (GO:0046085)2.49541537
180deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.48502644
181regulation of relaxation of muscle (GO:1901077)2.47199199

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.40903064
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.35247102
3EGR1_23403033_ChIP-Seq_LIVER_Mouse3.90619665
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.64028378
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.44456313
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.36911010
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.14628373
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.01551221
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.99499773
10SRF_21415370_ChIP-Seq_HL-1_Mouse2.85813928
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.82937643
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.74950519
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.73456945
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67490437
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.62352427
16E2F7_22180533_ChIP-Seq_HELA_Human2.55905100
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.53725960
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.41724259
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.36370588
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.35850225
21* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.18485431
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15091895
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11814308
24YY1_21170310_ChIP-Seq_MESCs_Mouse2.03991081
25FOXP3_21729870_ChIP-Seq_TREG_Human2.01582364
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.01387583
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.99812414
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99074618
29VDR_23849224_ChIP-Seq_CD4+_Human1.97658936
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97573999
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96308740
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94433448
33DCP1A_22483619_ChIP-Seq_HELA_Human1.91563120
34LXR_22158963_ChIP-Seq_LIVER_Mouse1.88540054
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.88156073
36ELK1_19687146_ChIP-ChIP_HELA_Human1.84874052
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.83192861
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.82935250
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77058129
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74525540
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62087798
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61485011
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60953225
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55482982
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53189718
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52095710
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.47328805
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44001301
49MYC_18940864_ChIP-ChIP_HL60_Human1.43660795
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.43494067
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42728826
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42631543
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42580544
54AR_21909140_ChIP-Seq_LNCAP_Human1.39697156
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.37927661
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36412341
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.35812932
58GATA4_21415370_ChIP-Seq_HL-1_Mouse1.35447254
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35344747
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34210200
61TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34063809
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33264693
63BP1_19119308_ChIP-ChIP_Hs578T_Human1.32009498
64IRF1_19129219_ChIP-ChIP_H3396_Human1.31660772
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.31390260
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29465910
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.28426887
68GABP_19822575_ChIP-Seq_HepG2_Human1.27150862
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25510246
70IRF8_22096565_ChIP-ChIP_GC-B_Human1.22274166
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20847456
72NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20736017
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19273271
74TFEB_21752829_ChIP-Seq_HELA_Human1.19236283
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.14292859
76TTF2_22483619_ChIP-Seq_HELA_Human1.12397591
77MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12040439
78STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11635285
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11528042
80KDM5A_27292631_Chip-Seq_BREAST_Human1.11324313
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11162607
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08989191
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08656603
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07274680
85NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06497916
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04708549
87E2F1_21310950_ChIP-Seq_MCF-7_Human1.03612093
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01513351
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00052290
90XRN2_22483619_ChIP-Seq_HELA_Human0.99791816
91NANOG_16153702_ChIP-ChIP_HESCs_Human0.99556679
92CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99126805
93MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98569490
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97714235
95ELF5_23300383_ChIP-Seq_T47D_Human0.97125585
96EZH2_27294783_Chip-Seq_NPCs_Mouse0.95741709
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95031946
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94939689
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94408532
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94096726
101HTT_18923047_ChIP-ChIP_STHdh_Human0.93581483
102KAP1_22055183_ChIP-Seq_ESCs_Mouse0.93144102
103SOX17_20123909_ChIP-Seq_XEN_Mouse0.92986892
104PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92146556
105POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91680108
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89919496
107STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88441621
108SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88366336
109NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.87998488
110POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87809956
111PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87556208
112CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86434182
113CRX_20693478_ChIP-Seq_RETINA_Mouse0.85240828
114SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83359655
115NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83058937
116CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.82385077
117KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.82122706
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81558866
119ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.79456328
120AR_20517297_ChIP-Seq_VCAP_Human0.78898174
121EOMES_21245162_ChIP-Seq_HESCs_Human0.78658882
122ZNF263_19887448_ChIP-Seq_K562_Human0.78588100
123TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76087227
124RUNX1_27457419_Chip-Seq_LIVER_Mouse0.75600173
125RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.75283697
126MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.73961897
127CTCF_18555785_ChIP-Seq_MESCs_Mouse0.73961561
128FUS_26573619_Chip-Seq_HEK293_Human0.73697115
129TP53_22573176_ChIP-Seq_HFKS_Human0.70546309

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.79983306
2MP0003806_abnormal_nucleotide_metabolis4.44666791
3MP0005085_abnormal_gallbladder_physiolo3.92835878
4MP0005365_abnormal_bile_salt3.45236467
5MP0005360_urolithiasis3.37273961
6MP0009697_abnormal_copulation3.29690384
7MP0004957_abnormal_blastocyst_morpholog3.07850519
8MP0000749_muscle_degeneration2.71156829
9MP0002837_dystrophic_cardiac_calcinosis2.69092842
10MP0002138_abnormal_hepatobiliary_system2.57698615
11MP0009379_abnormal_foot_pigmentation2.49144382
12MP0003195_calcinosis2.37197966
13MP0003646_muscle_fatigue2.33380178
14MP0008875_abnormal_xenobiotic_pharmacok2.30512670
15MP0006072_abnormal_retinal_apoptosis2.29120529
16MP0003252_abnormal_bile_duct2.21725373
17MP0003186_abnormal_redox_activity2.14479793
18MP0006036_abnormal_mitochondrial_physio1.98530925
19MP0003941_abnormal_skin_development1.98144182
20MP0003111_abnormal_nucleus_morphology1.92615690
21MP0001764_abnormal_homeostasis1.87929411
22MP0005332_abnormal_amino_acid1.86446622
23MP0003077_abnormal_cell_cycle1.86118109
24MP0003718_maternal_effect1.79260563
25MP0005084_abnormal_gallbladder_morpholo1.78182183
26MP0002938_white_spotting1.73059729
27MP0000358_abnormal_cell_content/1.70771837
28MP0004145_abnormal_muscle_electrophysio1.63775886
29MP0001529_abnormal_vocalization1.63284846
30MP0001727_abnormal_embryo_implantation1.60419186
31MP0005330_cardiomyopathy1.57332578
32MP0005408_hypopigmentation1.50036612
33MP0001986_abnormal_taste_sensitivity1.49414635
34MP0004147_increased_porphyrin_level1.49018062
35MP0002876_abnormal_thyroid_physiology1.48945859
36MP0002090_abnormal_vision1.48117371
37MP0006292_abnormal_olfactory_placode1.47696858
38MP0010329_abnormal_lipoprotein_level1.46950328
39MP0008877_abnormal_DNA_methylation1.45368307
40MP0002132_abnormal_respiratory_system1.42545279
41MP0005083_abnormal_biliary_tract1.42495131
42MP0002160_abnormal_reproductive_system1.41194792
43MP0001661_extended_life_span1.35890049
44MP0000372_irregular_coat_pigmentation1.32744830
45MP0008058_abnormal_DNA_repair1.31223392
46MP0006035_abnormal_mitochondrial_morpho1.30487157
47MP0005451_abnormal_body_composition1.28598166
48MP0003724_increased_susceptibility_to1.28534177
49MP0002638_abnormal_pupillary_reflex1.24519879
50MP0005075_abnormal_melanosome_morpholog1.23862867
51MP0004084_abnormal_cardiac_muscle1.22766270
52MP0005319_abnormal_enzyme/_coenzyme1.21754151
53MP0003011_delayed_dark_adaptation1.20536068
54MP0003136_yellow_coat_color1.20406256
55MP0001188_hyperpigmentation1.17318347
56MP0009840_abnormal_foam_cell1.14618900
57MP0000566_synostosis1.13305898
58MP0004782_abnormal_surfactant_physiolog1.11813652
59MP0004036_abnormal_muscle_relaxation1.10210992
60MP0002163_abnormal_gland_morphology1.08437737
61MP0004233_abnormal_muscle_weight1.07226467
62MP0004215_abnormal_myocardial_fiber1.07212000
63MP0001984_abnormal_olfaction1.07050092
64MP0005253_abnormal_eye_physiology1.06428452
65MP0003828_pulmonary_edema1.06283394
66MP0002009_preneoplasia1.05881879
67MP0002972_abnormal_cardiac_muscle1.05249901
68MP0008789_abnormal_olfactory_epithelium1.02319598
69MP0001666_abnormal_nutrient_absorption1.01599114
70MP0005266_abnormal_metabolism1.00859689
71MP0004019_abnormal_vitamin_homeostasis1.00446569
72MP0005220_abnormal_exocrine_pancreas0.99679626
73MP0001544_abnormal_cardiovascular_syste0.98870111
74MP0005385_cardiovascular_system_phenoty0.98870111
75MP0002736_abnormal_nociception_after0.97423883
76MP0000609_abnormal_liver_physiology0.96872710
77MP0005636_abnormal_mineral_homeostasis0.96322825
78MP0002118_abnormal_lipid_homeostasis0.96271376
79MP0000015_abnormal_ear_pigmentation0.94725575
80MP0004381_abnormal_hair_follicle0.93872191
81MP0001730_embryonic_growth_arrest0.93558792
82MP0001905_abnormal_dopamine_level0.92631931
83MP0005379_endocrine/exocrine_gland_phen0.92630548
84MP0003786_premature_aging0.91332832
85MP0003137_abnormal_impulse_conducting0.90337118
86MP0002269_muscular_atrophy0.89680972
87MP0001835_abnormal_antigen_presentation0.89001839
88MP0008007_abnormal_cellular_replicative0.88210895
89MP0002102_abnormal_ear_morphology0.87985603
90MP0000751_myopathy0.87959347
91MP0000350_abnormal_cell_proliferation0.87765394
92MP0006276_abnormal_autonomic_nervous0.87471201
93MP0003950_abnormal_plasma_membrane0.87012487
94MP0009764_decreased_sensitivity_to0.86636927
95MP0001542_abnormal_bone_strength0.85990879
96MP0002148_abnormal_hypersensitivity_rea0.85333375
97MP0005165_increased_susceptibility_to0.84796715
98MP0010368_abnormal_lymphatic_system0.84447608
99MP0002210_abnormal_sex_determination0.83908776
100MP0002127_abnormal_cardiovascular_syste0.82858304
101MP0000747_muscle_weakness0.81983554
102MP0008057_abnormal_DNA_replication0.81675280
103MP0005367_renal/urinary_system_phenotyp0.80950721
104MP0000516_abnormal_urinary_system0.80950721
105MP0005620_abnormal_muscle_contractility0.80843925
106MP0005389_reproductive_system_phenotype0.80781022
107MP0001293_anophthalmia0.80550454
108MP0001697_abnormal_embryo_size0.79850085
109MP0000598_abnormal_liver_morphology0.79309386
110MP0005670_abnormal_white_adipose0.78732280
111MP0008775_abnormal_heart_ventricle0.78036861
112MP0003567_abnormal_fetal_cardiomyocyte0.78014460
113MP0001929_abnormal_gametogenesis0.77376557
114MP0010030_abnormal_orbit_morphology0.77318531
115MP0003868_abnormal_feces_composition0.76419456
116MP0002106_abnormal_muscle_physiology0.76418482
117MP0005410_abnormal_fertilization0.76191672
118MP0006138_congestive_heart_failure0.74939112
119MP0005171_absent_coat_pigmentation0.74787500
120MP0008932_abnormal_embryonic_tissue0.74739180
121MP0001919_abnormal_reproductive_system0.74738974
122MP0005584_abnormal_enzyme/coenzyme_acti0.74164150
123MP0005647_abnormal_sex_gland0.73774404
124MP0000647_abnormal_sebaceous_gland0.73327728
125MP0010386_abnormal_urinary_bladder0.73019267
126MP0009763_increased_sensitivity_to0.72799065
127MP0004087_abnormal_muscle_fiber0.71646230
128MP0005395_other_phenotype0.71525025
129MP0003191_abnormal_cellular_cholesterol0.71210589
130MP0000653_abnormal_sex_gland0.70099498
131MP0005376_homeostasis/metabolism_phenot0.69756488
132MP0009643_abnormal_urine_homeostasis0.68733527
133MP0009765_abnormal_xenobiotic_induced0.68003167
134MP0008469_abnormal_protein_level0.67686926
135MP0001145_abnormal_male_reproductive0.67436131
136MP0002877_abnormal_melanocyte_morpholog0.67395721
137MP0001853_heart_inflammation0.66879107
138MP0001324_abnormal_eye_pigmentation0.66621354
139MP0000750_abnormal_muscle_regeneration0.66367091
140MP0003693_abnormal_embryo_hatching0.65524330
141MP0001119_abnormal_female_reproductive0.64941982
142MP0010094_abnormal_chromosome_stability0.64675944
143MP0002095_abnormal_skin_pigmentation0.63097232
144MP0005369_muscle_phenotype0.63070979
145MP0001881_abnormal_mammary_gland0.62059130
146MP0000313_abnormal_cell_death0.60993628
147MP0002080_prenatal_lethality0.60796425

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.05108786
2Hepatic necrosis (HP:0002605)4.02831877
3Abnormal mitochondria in muscle tissue (HP:0008316)3.86319743
4Acute encephalopathy (HP:0006846)3.83159334
5Mitochondrial inheritance (HP:0001427)3.71440735
6Hepatocellular necrosis (HP:0001404)3.68461716
7Prolonged partial thromboplastin time (HP:0003645)3.61121431
8Abnormality of aromatic amino acid family metabolism (HP:0004338)3.58709120
9Cerebral edema (HP:0002181)3.57160778
10Renal cortical cysts (HP:0000803)3.51905760
11Increased CSF lactate (HP:0002490)3.50391708
12Progressive macrocephaly (HP:0004481)3.41388595
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.26475931
14Abnormality of fatty-acid metabolism (HP:0004359)3.20853492
15Abnormality of pyrimidine metabolism (HP:0004353)3.19918268
16Intrahepatic cholestasis (HP:0001406)3.17267362
17Lipid accumulation in hepatocytes (HP:0006561)3.17168986
18Hypoglycemic coma (HP:0001325)3.06397141
19Increased hepatocellular lipid droplets (HP:0006565)3.04400812
20Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.03116907
21Decreased activity of mitochondrial respiratory chain (HP:0008972)2.96477179
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.96477179
23Lactic acidosis (HP:0003128)2.96121272
24Abnormality of monocarboxylic acid metabolism (HP:0010996)2.93091781
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.88498595
26Increased serum lactate (HP:0002151)2.85939031
27Renal Fanconi syndrome (HP:0001994)2.82582334
28Lethargy (HP:0001254)2.80602656
29Increased intramyocellular lipid droplets (HP:0012240)2.80016559
30Nemaline bodies (HP:0003798)2.79299133
31Hyperglycinemia (HP:0002154)2.78215764
32Hyperglycinuria (HP:0003108)2.77940975
33Joint hemorrhage (HP:0005261)2.77448765
34Abnormality of urine glucose concentration (HP:0011016)2.77139189
35Glycosuria (HP:0003076)2.77139189
36Increased muscle lipid content (HP:0009058)2.72127973
37Proximal tubulopathy (HP:0000114)2.71964938
38Generalized aminoaciduria (HP:0002909)2.71721967
39Dicarboxylic aciduria (HP:0003215)2.70204826
40Abnormality of dicarboxylic acid metabolism (HP:0010995)2.70204826
41Exercise intolerance (HP:0003546)2.68950941
42Type I transferrin isoform profile (HP:0003642)2.67552193
43Reduced antithrombin III activity (HP:0001976)2.65067295
44Abnormality of methionine metabolism (HP:0010901)2.63937831
45Chromosomal breakage induced by crosslinking agents (HP:0003221)2.59653142
46Hypobetalipoproteinemia (HP:0003563)2.57438395
473-Methylglutaconic aciduria (HP:0003535)2.56734824
48Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.55960449
49Muscle fiber inclusion bodies (HP:0100299)2.55221953
50Methylmalonic aciduria (HP:0012120)2.52304901
51Optic disc pallor (HP:0000543)2.51139654
52Aplastic anemia (HP:0001915)2.50923763
53Leukodystrophy (HP:0002415)2.50592646
54Abnormality of serum amino acid levels (HP:0003112)2.49827548
55Exercise-induced muscle cramps (HP:0003710)2.49202901
56Hyperammonemia (HP:0001987)2.47760271
57Exertional dyspnea (HP:0002875)2.45530797
58Methylmalonic acidemia (HP:0002912)2.45309275
59Conjugated hyperbilirubinemia (HP:0002908)2.42047499
60Microvesicular hepatic steatosis (HP:0001414)2.41261997
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.41034686
62Respiratory failure (HP:0002878)2.39500989
63Palpitations (HP:0001962)2.38963893
64Abnormality of serine family amino acid metabolism (HP:0010894)2.37762457
65Abnormality of glycine metabolism (HP:0010895)2.37762457
66Chromsome breakage (HP:0040012)2.36173928
67Opisthotonus (HP:0002179)2.33399483
68Macrocytic anemia (HP:0001972)2.31285290
69Ketosis (HP:0001946)2.30565184
70Oral leukoplakia (HP:0002745)2.29967000
71Prolonged neonatal jaundice (HP:0006579)2.29276501
72Reticulocytopenia (HP:0001896)2.28638950
73Ventricular tachycardia (HP:0004756)2.28130191
74Lipoatrophy (HP:0100578)2.27383825
75Hyperlipoproteinemia (HP:0010980)2.26931160
76Degeneration of anterior horn cells (HP:0002398)2.24712900
77Abnormality of the anterior horn cell (HP:0006802)2.24712900
78Hypothermia (HP:0002045)2.23866886
79Metabolic acidosis (HP:0001942)2.22593052
80Ketoacidosis (HP:0001993)2.21302883
81Nausea (HP:0002018)2.20176834
82Dilated cardiomyopathy (HP:0001644)2.18314701
83Xanthomatosis (HP:0000991)2.15541254
84Abnormality of cells of the erythroid lineage (HP:0012130)2.15532166
85Progressive muscle weakness (HP:0003323)2.15216405
86Osteomalacia (HP:0002749)2.14409172
87Calf muscle hypertrophy (HP:0008981)2.11082197
88Progressive external ophthalmoplegia (HP:0000590)2.10842998
89Renal tubular dysfunction (HP:0000124)2.10808574
90Abnormality of placental membranes (HP:0011409)2.08756401
91Amniotic constriction ring (HP:0009775)2.08756401
92Abnormality of the intrinsic pathway (HP:0010989)2.07743839
93Abnormal number of erythroid precursors (HP:0012131)2.07703920
94Ragged-red muscle fibers (HP:0003200)2.07055333
95Respiratory difficulties (HP:0002880)2.05694570
96Multiple enchondromatosis (HP:0005701)2.05401389
97Hyperbilirubinemia (HP:0002904)2.02438740
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02364439
99Abnormality of alanine metabolism (HP:0010916)2.02364439
100Hyperalaninemia (HP:0003348)2.02364439
101Abnormality of glycolysis (HP:0004366)2.01880738
102Increased serum pyruvate (HP:0003542)2.01880738
103Neoplasm of the adrenal gland (HP:0100631)2.01645912
104Distal lower limb muscle weakness (HP:0009053)2.00110790
105Abnormality of renal resorption (HP:0011038)1.99328494
106Vomiting (HP:0002013)1.98930787
107Hypolipoproteinemia (HP:0010981)1.98742933
108Atrial fibrillation (HP:0005110)1.97940534
109Fat malabsorption (HP:0002630)1.97682305
110Pancytopenia (HP:0001876)1.95513303
111Rhabdomyolysis (HP:0003201)1.94796889
112Myoglobinuria (HP:0002913)1.94371390
113Hyperphosphaturia (HP:0003109)1.91980174
114Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.91869211
115Cerebral palsy (HP:0100021)1.91672434
116Muscle hypertrophy of the lower extremities (HP:0008968)1.89950747
117Cerebral hypomyelination (HP:0006808)1.87984548
118Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86571719
119Abnormal protein N-linked glycosylation (HP:0012347)1.86571719
120Abnormal protein glycosylation (HP:0012346)1.86571719
121Abnormal glycosylation (HP:0012345)1.86571719
122Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86439537
123Testicular atrophy (HP:0000029)1.85314095
124Abnormality of the left ventricular outflow tract (HP:0011103)1.84175118
125Subaortic stenosis (HP:0001682)1.84175118
126Sparse eyelashes (HP:0000653)1.83608402
127X-linked dominant inheritance (HP:0001423)1.80897261
128CNS demyelination (HP:0007305)1.80497589
129Hyperinsulinemic hypoglycemia (HP:0000825)1.80211202
130Spastic paraparesis (HP:0002313)1.77702742
131Short tibia (HP:0005736)1.77051429
132Emotional lability (HP:0000712)1.74681837
133Conjunctival hamartoma (HP:0100780)1.73709644
134Hypoglycemic seizures (HP:0002173)1.68617897
135Aplasia/hypoplasia of the uterus (HP:0008684)1.68191695
136Medial flaring of the eyebrow (HP:0010747)1.67225994
137Megaloblastic anemia (HP:0001889)1.64901258
138Symptomatic seizures (HP:0011145)1.62578556
139Congenital, generalized hypertrichosis (HP:0004540)1.61174688

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.12292375
2ZAK3.86172009
3VRK23.48242390
4MST43.32064117
5BCKDK3.17531800
6NEK13.10754080
7CASK2.73184218
8PDK22.39999915
9NME22.37524541
10EIF2AK12.26949508
11SRPK12.25067379
12MKNK12.24597201
13IRAK32.15960257
14MKNK22.13317064
15STK38L2.06266332
16MAP3K141.99941958
17NEK91.96973434
18AKT31.86298511
19MYLK1.83621024
20MUSK1.80580026
21OBSCN1.77649517
22TSSK61.75926683
23IRAK41.73467415
24EIF2AK21.65153243
25EIF2AK31.63620717
26BUB11.62347765
27CDC71.60091403
28PINK11.56689496
29PRPF4B1.55512907
30SIK31.52067579
31TLK11.48833309
32NUAK11.45170895
33PIM21.43089040
34ACVR1B1.37879117
35PLK41.31172164
36PIK3CA1.30185887
37SCYL21.27015158
38TRIM281.23342297
39MAP2K71.23135526
40MAP4K21.19414603
41BMPR21.16439494
42WNK31.16310074
43TESK11.16206902
44YES11.12709237
45MAPKAPK31.11561537
46VRK11.11476513
47INSRR1.08026552
48STK41.06919852
49SGK21.04035230
50TIE11.00261786
51LMTK20.99196669
52TNIK0.98170546
53IKBKB0.93806685
54TXK0.93387001
55TRPM70.90942251
56STK240.89901070
57PAK40.88246917
58PIK3CG0.86520979
59IKBKE0.84558809
60ADRBK20.83480378
61FLT30.82834728
62TEC0.82268165
63FRK0.82178110
64PIM10.81185292
65BRSK10.80466040
66PBK0.78676907
67ERBB30.77769497
68BRAF0.76511518
69TAF10.75462270
70IRAK10.72489522
71CSNK1G30.71675182
72PLK20.69292634
73DAPK10.68264457
74CSNK1G10.67462400
75CDK80.64218760
76AURKA0.63546463
77STK390.62546598
78CHUK0.61607760
79MAP3K110.61479329
80NLK0.61038089
81MAP3K50.60971437
82NME10.60967894
83PRKCI0.60650970
84RPS6KB20.60117174
85TTK0.59836618
86CSNK1G20.59515561
87ABL20.58587902
88CLK10.58508914
89WEE10.58387028
90CSNK2A10.57949994
91CCNB10.57512345
92GRK10.57199293
93PLK30.57154295
94WNK40.57096548
95CDK30.56526967
96TESK20.54691144
97ERBB40.54184201
98EPHA20.53693263
99DAPK30.53551769
100BMPR1B0.53085253
101RPS6KA50.52976152
102RPS6KA60.52928502
103ILK0.52694967
104DYRK20.52370837
105NEK60.52314731
106RPS6KB10.51915922
107BCR0.51259386
108TAOK30.50759632
109SGK2230.49943674
110SGK4940.49943674
111KDR0.49056859
112GRK70.48131590
113RPS6KC10.47774529
114RPS6KL10.47774529
115NEK20.46076586
116PLK10.45943875
117PHKG10.45749709
118PHKG20.45749709
119CHEK20.44192696
120TAOK20.44184980
121MST1R0.44012748
122PKN10.43958474
123PNCK0.43676257
124BRSK20.42231368
125OXSR10.42035784
126CDK190.40814298
127ATR0.40288940
128MAP3K120.40056561
129CAMK2G0.38156409
130PRKCE0.37973666
131AURKB0.37846357
132JAK30.37555474
133MAP2K60.35056116
134SGK30.34514729
135STK30.34489134
136PAK30.33110418
137CSNK2A20.33088386
138TBK10.33034461
139CAMK2D0.32978018
140LIMK10.32782617
141STK100.32551134
142MET0.31662865
143FER0.31470567
144CSNK1A1L0.29564019
145ATM0.29345199
146DYRK30.28772712
147LRRK20.28703188

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.73014916
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.63171497
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18970827
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.17910757
5Oxidative phosphorylation_Homo sapiens_hsa001902.11391138
6One carbon pool by folate_Homo sapiens_hsa006702.08890070
7Peroxisome_Homo sapiens_hsa041462.05895272
8Fatty acid degradation_Homo sapiens_hsa000712.03249632
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.01103658
10Propanoate metabolism_Homo sapiens_hsa006402.00550657
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.00031104
12Proteasome_Homo sapiens_hsa030501.96723489
13Parkinsons disease_Homo sapiens_hsa050121.95987225
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.95820232
15Tryptophan metabolism_Homo sapiens_hsa003801.95024303
16RNA polymerase_Homo sapiens_hsa030201.88194489
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.87934922
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.78914370
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.76371817
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.74500063
21Fatty acid elongation_Homo sapiens_hsa000621.71367163
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.67301730
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.61133363
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.60966752
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58071523
26Protein export_Homo sapiens_hsa030601.56775424
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.55249197
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.50572010
29Ribosome_Homo sapiens_hsa030101.47023223
30Pyrimidine metabolism_Homo sapiens_hsa002401.41858780
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40242893
32Chemical carcinogenesis_Homo sapiens_hsa052041.39876970
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.39318276
34beta-Alanine metabolism_Homo sapiens_hsa004101.38983987
35Sulfur metabolism_Homo sapiens_hsa009201.37449115
36Huntingtons disease_Homo sapiens_hsa050161.37172392
37Folate biosynthesis_Homo sapiens_hsa007901.37103439
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36224726
39Retinol metabolism_Homo sapiens_hsa008301.33816427
40Pyruvate metabolism_Homo sapiens_hsa006201.32549190
41Homologous recombination_Homo sapiens_hsa034401.30159539
42Starch and sucrose metabolism_Homo sapiens_hsa005001.30156839
43Carbon metabolism_Homo sapiens_hsa012001.29698974
44DNA replication_Homo sapiens_hsa030301.29242426
45Complement and coagulation cascades_Homo sapiens_hsa046101.28547757
46Fatty acid metabolism_Homo sapiens_hsa012121.27539662
47Selenocompound metabolism_Homo sapiens_hsa004501.26817806
48Mismatch repair_Homo sapiens_hsa034301.16893125
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16742679
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.16502757
51Arginine biosynthesis_Homo sapiens_hsa002201.16409867
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16047681
53Alzheimers disease_Homo sapiens_hsa050101.15822548
54Butanoate metabolism_Homo sapiens_hsa006501.14645530
55Tyrosine metabolism_Homo sapiens_hsa003501.10016358
56Base excision repair_Homo sapiens_hsa034101.08295213
57Arginine and proline metabolism_Homo sapiens_hsa003301.04149896
58Phenylalanine metabolism_Homo sapiens_hsa003601.03035624
59Fanconi anemia pathway_Homo sapiens_hsa034601.02205051
60Histidine metabolism_Homo sapiens_hsa003401.01788497
61Maturity onset diabetes of the young_Homo sapiens_hsa049501.00148223
62Nucleotide excision repair_Homo sapiens_hsa034200.98610233
63Biosynthesis of amino acids_Homo sapiens_hsa012300.96366509
64Glutathione metabolism_Homo sapiens_hsa004800.95179072
65PPAR signaling pathway_Homo sapiens_hsa033200.93084761
66Vitamin B6 metabolism_Homo sapiens_hsa007500.92146908
67Sulfur relay system_Homo sapiens_hsa041220.92146274
68Metabolic pathways_Homo sapiens_hsa011000.90826402
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87609096
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84248948
71Basal transcription factors_Homo sapiens_hsa030220.84182441
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83897077
73Arachidonic acid metabolism_Homo sapiens_hsa005900.83482678
74Cardiac muscle contraction_Homo sapiens_hsa042600.76770709
75ABC transporters_Homo sapiens_hsa020100.76035808
76Purine metabolism_Homo sapiens_hsa002300.75852605
77Collecting duct acid secretion_Homo sapiens_hsa049660.72531097
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72334726
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70531878
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67673503
81RNA degradation_Homo sapiens_hsa030180.66431687
82Galactose metabolism_Homo sapiens_hsa000520.65984663
83Cell cycle_Homo sapiens_hsa041100.65883692
84N-Glycan biosynthesis_Homo sapiens_hsa005100.65752699
85Pentose phosphate pathway_Homo sapiens_hsa000300.63611821
86Staphylococcus aureus infection_Homo sapiens_hsa051500.62265214
87Spliceosome_Homo sapiens_hsa030400.62089808
88Vitamin digestion and absorption_Homo sapiens_hsa049770.59873575
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58349937
90Steroid biosynthesis_Homo sapiens_hsa001000.56498129
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53032934
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51235506
93Non-homologous end-joining_Homo sapiens_hsa034500.51186300
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.50772949
95Fat digestion and absorption_Homo sapiens_hsa049750.45042978
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43392796
97Regulation of autophagy_Homo sapiens_hsa041400.39847284
98Fructose and mannose metabolism_Homo sapiens_hsa000510.39740118
99RNA transport_Homo sapiens_hsa030130.39569238
100Oocyte meiosis_Homo sapiens_hsa041140.38651893
101Linoleic acid metabolism_Homo sapiens_hsa005910.38364562
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36574794
103Lysine degradation_Homo sapiens_hsa003100.35664597
104Systemic lupus erythematosus_Homo sapiens_hsa053220.35510678
105Autoimmune thyroid disease_Homo sapiens_hsa053200.34056983
106Vibrio cholerae infection_Homo sapiens_hsa051100.33240761
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32640723
108p53 signaling pathway_Homo sapiens_hsa041150.32388626
109mRNA surveillance pathway_Homo sapiens_hsa030150.30739040
110Epstein-Barr virus infection_Homo sapiens_hsa051690.23727554
111Mineral absorption_Homo sapiens_hsa049780.22959343
112Rheumatoid arthritis_Homo sapiens_hsa053230.20205768
113Nitrogen metabolism_Homo sapiens_hsa009100.20028812
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10678524

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