TIMP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)7.36624638
2chondrocyte proliferation (GO:0035988)6.27763464
3cartilage development involved in endochondral bone morphogenesis (GO:0060351)6.11261685
4wound healing, spreading of epidermal cells (GO:0035313)5.57338794
5protein heterotrimerization (GO:0070208)5.43836051
6skin morphogenesis (GO:0043589)5.40470973
7sequestering of extracellular ligand from receptor (GO:0035581)5.31770367
8endodermal cell differentiation (GO:0035987)5.19994105
9peptidyl-proline hydroxylation (GO:0019511)5.13600316
10cell adhesion mediated by integrin (GO:0033627)4.77495141
11protein retention in ER lumen (GO:0006621)4.75601208
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.73652993
13chondrocyte development (GO:0002063)4.72577134
14collagen metabolic process (GO:0032963)4.54049779
15collagen catabolic process (GO:0030574)4.43186626
16positive regulation of astrocyte differentiation (GO:0048711)4.42424010
17wound healing, spreading of cells (GO:0044319)4.42012053
18keratan sulfate catabolic process (GO:0042340)4.40928444
19positive regulation of endothelial cell apoptotic process (GO:2000353)4.36967018
20regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.34365484
21dermatan sulfate biosynthetic process (GO:0030208)4.33395152
22endothelial cell morphogenesis (GO:0001886)4.33267035
23regulation of tight junction assembly (GO:2000810)4.27546797
24cell migration involved in heart development (GO:0060973)4.19278377
25multicellular organismal macromolecule metabolic process (GO:0044259)4.18420259
26positive regulation of chemokine biosynthetic process (GO:0045080)4.17070508
27fibril organization (GO:0097435)4.14667701
28protein hydroxylation (GO:0018126)4.13475618
29cellular response to zinc ion (GO:0071294)4.10210722
30bone trabecula formation (GO:0060346)4.09281526
31positive regulation of extracellular matrix organization (GO:1903055)4.08647032
32negative regulation of axon extension involved in axon guidance (GO:0048843)4.04548912
33multicellular organismal catabolic process (GO:0044243)4.01808392
34cellular response to vitamin D (GO:0071305)4.00189398
35regulation of macrophage cytokine production (GO:0010935)3.97801793
36cell aggregation (GO:0098743)3.95792706
37cartilage condensation (GO:0001502)3.95792706
38extracellular fibril organization (GO:0043206)3.94916882
39multicellular organismal metabolic process (GO:0044236)3.93924536
40regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.93891851
41positive regulation of macrophage cytokine production (GO:0060907)3.90759498
42regulation of chemokine biosynthetic process (GO:0045073)3.86811412
43dermatan sulfate metabolic process (GO:0030205)3.86665540
44notochord development (GO:0030903)3.82519262
45COPI coating of Golgi vesicle (GO:0048205)3.78168209
46Golgi transport vesicle coating (GO:0048200)3.78168209
47negative regulation of fatty acid transport (GO:2000192)3.74945142
48chondroitin sulfate biosynthetic process (GO:0030206)3.74123553
49regulation of plasminogen activation (GO:0010755)3.73440277
50* extracellular matrix disassembly (GO:0022617)3.73419175
51cellular response to vitamin (GO:0071295)3.72676131
52protein maturation by protein folding (GO:0022417)3.70010891
53negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.64570382
54lung vasculature development (GO:0060426)3.60097869
55adhesion of symbiont to host (GO:0044406)3.58140523
56virion attachment to host cell (GO:0019062)3.56811653
57adhesion of symbiont to host cell (GO:0044650)3.56811653
58hyaluronan catabolic process (GO:0030214)3.56622661
59mesenchymal-epithelial cell signaling (GO:0060638)3.56420678
60positive regulation of blood vessel endothelial cell migration (GO:0043536)3.52094871
61positive regulation of osteoblast proliferation (GO:0033690)3.51603070
62decidualization (GO:0046697)3.50895167
63regulation of gonadotropin secretion (GO:0032276)3.49219361
64regulation of cytokine secretion involved in immune response (GO:0002739)3.45480402
65positive regulation of protein kinase C signaling (GO:0090037)3.44178152
66epithelial cell-cell adhesion (GO:0090136)3.43176611
67positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.38168678
68negative regulation of stem cell proliferation (GO:2000647)3.35666776
69positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.34284458
70positive regulation of interleukin-8 secretion (GO:2000484)3.29888386
71cellular response to interferon-alpha (GO:0035457)3.29680039
72response to gravity (GO:0009629)3.28697790
73* extracellular matrix organization (GO:0030198)3.26410211
74positive regulation of epithelial to mesenchymal transition (GO:0010718)3.25905086
75regulation of collagen metabolic process (GO:0010712)3.25276643
76* extracellular structure organization (GO:0043062)3.25229065
77apoptotic cell clearance (GO:0043277)3.22953027
78extracellular matrix assembly (GO:0085029)3.18821233
79positive regulation of macrophage activation (GO:0043032)3.18727426
80negative regulation of chondrocyte differentiation (GO:0032331)3.16924743
81regulation of interleukin-8 secretion (GO:2000482)3.09332912
82kidney mesenchyme development (GO:0072074)3.08703321
83nucleotide-sugar biosynthetic process (GO:0009226)3.06718264
84mammary gland epithelial cell proliferation (GO:0033598)3.06443453
85regulation of vitamin D biosynthetic process (GO:0060556)3.04670987
86basement membrane organization (GO:0071711)3.03763814
87endochondral ossification (GO:0001958)3.03712044
88replacement ossification (GO:0036075)3.03712044
89barbed-end actin filament capping (GO:0051016)3.01720764
90negative regulation of smooth muscle cell migration (GO:0014912)3.01204110
91endocrine hormone secretion (GO:0060986)3.00854244
92substrate-dependent cell migration (GO:0006929)2.99301352
93negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.98149654
94tooth mineralization (GO:0034505)2.97164259
95type B pancreatic cell proliferation (GO:0044342)2.96987051
96negative regulation of axon guidance (GO:1902668)2.96386273
97UDP-N-acetylglucosamine metabolic process (GO:0006047)2.95380967
98positive regulation of cartilage development (GO:0061036)2.95235307
99response to vitamin D (GO:0033280)2.92538765
100membrane raft organization (GO:0031579)2.91911945
101fibrinolysis (GO:0042730)2.87769946
102vagina development (GO:0060068)2.87456588
103midgut development (GO:0007494)2.86817042
104metanephric mesenchyme development (GO:0072075)2.83809838
105epithelial to mesenchymal transition (GO:0001837)2.82778946
106regulation of monocyte chemotaxis (GO:0090025)2.80569824
107cellular response to cadmium ion (GO:0071276)2.80128749
108positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.79551751
109craniofacial suture morphogenesis (GO:0097094)2.79207634
110regulation of cartilage development (GO:0061035)2.78586776
111protein targeting to plasma membrane (GO:0072661)2.78569527
112positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.77937032
113regulation of smooth muscle cell migration (GO:0014910)2.77254499
114regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.76591606
115neuron projection extension involved in neuron projection guidance (GO:1902284)2.72693871
116axon extension involved in axon guidance (GO:0048846)2.72693871
117embryonic skeletal joint morphogenesis (GO:0060272)2.72161598
118negative regulation of cartilage development (GO:0061037)2.71679676
119planar cell polarity pathway involved in neural tube closure (GO:0090179)2.71311010
120substrate adhesion-dependent cell spreading (GO:0034446)2.69672258
121protein localization to cell surface (GO:0034394)2.68991219
122cartilage development (GO:0051216)2.68713551
123regulation of collagen biosynthetic process (GO:0032965)2.68355304
124regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.68280186
125extracellular regulation of signal transduction (GO:1900115)2.66707913
126extracellular negative regulation of signal transduction (GO:1900116)2.66707913
127embryo implantation (GO:0007566)2.66259151
128muscle cell migration (GO:0014812)2.64548707
129protein localization to endosome (GO:0036010)2.64489702
130negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.64436166
131regulation of vitamin metabolic process (GO:0030656)2.63342006
132positive regulation of collagen biosynthetic process (GO:0032967)2.61956396
133positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.60976792
134regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.60976792
135negative regulation of homotypic cell-cell adhesion (GO:0034111)2.60516630
136regulation of chondrocyte differentiation (GO:0032330)2.59276154
137* regulation of integrin-mediated signaling pathway (GO:2001044)2.59258048
138stress fiber assembly (GO:0043149)2.58554623
139positive regulation of natural killer cell differentiation (GO:0032825)2.58270557
140* wound healing (GO:0042060)2.57661291
141regulation of apoptotic process involved in morphogenesis (GO:1902337)2.57464749
142vascular endothelial growth factor signaling pathway (GO:0038084)2.56349348
143glycosaminoglycan biosynthetic process (GO:0006024)2.56267785
144negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.56266950
145ossification (GO:0001503)2.55361946
146proteoglycan metabolic process (GO:0006029)2.55344398
147COPII vesicle coating (GO:0048208)2.55331492
148regulation of extracellular matrix disassembly (GO:0010715)2.54880733
149negative regulation of nitric oxide biosynthetic process (GO:0045019)2.53963182
150mesodermal cell differentiation (GO:0048333)2.53753579
151regulation of axon extension involved in axon guidance (GO:0048841)2.53465255
152* platelet degranulation (GO:0002576)2.52345510
153glycosaminoglycan catabolic process (GO:0006027)2.51963521
154positive regulation of collagen metabolic process (GO:0010714)2.50239466

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human8.45032005
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.75052864
3RARG_19884340_ChIP-ChIP_MEFs_Mouse5.82536283
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.70972595
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.59441312
6RUNX2_24764292_ChIP-Seq_MC3T3_Mouse3.46906886
7TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human3.04907571
8CLOCK_20551151_ChIP-Seq_293T_Human2.96470051
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.82507800
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.80548176
11CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.73291579
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.70165182
13CJUN_26792858_Chip-Seq_BT549_Human2.63477728
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.55481505
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.48030506
16CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.37525745
17ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.35860867
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.34456031
19BRD4_25478319_ChIP-Seq_HGPS_Human2.27187278
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.20471456
21WT1_19549856_ChIP-ChIP_CCG9911_Human2.15693101
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.12619289
23SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.10493770
24SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.10493770
25ELK3_25401928_ChIP-Seq_HUVEC_Human2.09933930
26ESR1_21235772_ChIP-Seq_MCF-7_Human2.08513388
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.01759621
28JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.98169836
29ELK1_22589737_ChIP-Seq_MCF10A_Human1.93316853
30NRF2_20460467_ChIP-Seq_MEFs_Mouse1.84620557
31NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.84620557
32JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.82582131
33ATF3_27146783_Chip-Seq_COLON_Human1.81049444
34SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.79103929
35HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.68435397
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.64475837
37SMC1_22415368_ChIP-Seq_MEFs_Mouse1.62179312
38SOX2_20726797_ChIP-Seq_SW620_Human1.60531503
39TP53_22127205_ChIP-Seq_IMR90_Human1.55130721
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54945415
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.49985604
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.49822898
43ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.49405349
44FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48866583
45UBF1/2_26484160_Chip-Seq_HMECs_Human1.47112074
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45391250
47P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44932737
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42213625
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41779313
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41211858
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40612314
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37591516
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.37332733
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.37063205
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.34713862
56TP53_20018659_ChIP-ChIP_R1E_Mouse1.32003920
57SMC3_22415368_ChIP-Seq_MEFs_Mouse1.31743688
58RXR_22158963_ChIP-Seq_LIVER_Mouse1.31212258
59TP53_18474530_ChIP-ChIP_U2OS_Human1.31162238
60P63_26484246_Chip-Seq_KERATINOCYTES_Human1.26422258
61NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.25933200
62TP53_23651856_ChIP-Seq_MEFs_Mouse1.25014640
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24937205
64ZNF263_19887448_ChIP-Seq_K562_Human1.24320802
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20487891
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20154769
67RACK7_27058665_Chip-Seq_MCF-7_Human1.19030996
68IRF8_22096565_ChIP-ChIP_GC-B_Human1.18286399
69FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.15726308
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15198645
71NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14394109
72MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.13853518
73TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10432706
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09767702
75ELK1_19687146_ChIP-ChIP_HELA_Human1.08672927
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08398202
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07174338
78EP300_21415370_ChIP-Seq_HL-1_Mouse1.06652456
79SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05034633
80ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04755251
81EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04595773
82TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03600082
83EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01962050
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01488626
85SA1_22415368_ChIP-Seq_MEFs_Mouse1.01003321
86ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00411440
87* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00087924
88NFI_21473784_ChIP-Seq_ESCs_Mouse1.00006016
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96055179
90FOXO3_23340844_ChIP-Seq_DLD1_Human0.94394662
91AR_21909140_ChIP-Seq_LNCAP_Human0.94027851
92TP53_16413492_ChIP-PET_HCT116_Human0.93982438
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90952692
94TFEB_21752829_ChIP-Seq_HELA_Human0.90348470
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90108786
96MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90057967
97PPARA_22158963_ChIP-Seq_LIVER_Mouse0.89390633
98RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88407030
99CSB_26484114_Chip-Seq_FIBROBLAST_Human0.87946815
100RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87586566
101RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87137533
102SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85144206
103NELFA_20434984_ChIP-Seq_ESCs_Mouse0.84660658
104IRF8_27001747_Chip-Seq_BMDM_Mouse0.84569321
105SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84285607
106GATA2_21666600_ChIP-Seq_HMVEC_Human0.83990995
107STAT4_19710469_ChIP-ChIP_TH1__Mouse0.83976737
108FOXM1_23109430_ChIP-Seq_U2OS_Human0.83471751
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82837339
110ZFP281_18757296_ChIP-ChIP_E14_Mouse0.82348421
111PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.81409374
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.78435224
113LXR_22158963_ChIP-Seq_LIVER_Mouse0.78380488
114MYB_21317192_ChIP-Seq_ERMYB_Mouse0.78129010
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76143671
116MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.75839447
117TBX20_22328084_ChIP-Seq_HEART_Mouse0.75829766
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.75829766
119BRD4_27068464_Chip-Seq_AML-cells_Mouse0.75666027
120GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.73258100
121VDR_24787735_ChIP-Seq_THP-1_Human0.73021439
122GATA3_24758297_ChIP-Seq_MCF-7_Human0.72146399
123KLF4_18555785_ChIP-Seq_MESCs_Mouse0.71690100
124NANOG_16153702_ChIP-ChIP_HESCs_Human0.71658383
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70904535
126LXR_22292898_ChIP-Seq_THP-1_Human0.70837050
127FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.70822074

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.80847134
2MP0005503_abnormal_tendon_morphology5.34403600
3MP0005275_abnormal_skin_tensile4.81480513
4MP0003705_abnormal_hypodermis_morpholog4.76215964
5* MP0003279_aneurysm3.90836100
6MP0001958_emphysema3.23307353
7MP0009384_cardiac_valve_regurgitation3.05217100
8MP0001542_abnormal_bone_strength2.69241852
9MP0005023_abnormal_wound_healing2.66884676
10MP0002254_reproductive_system_inflammat2.47805492
11MP0003566_abnormal_cell_adhesion2.44443354
12MP0010352_gastrointestinal_tract_polyps2.39193915
13MP0009840_abnormal_foam_cell2.37135354
14MP0005508_abnormal_skeleton_morphology2.30659581
15MP0002933_joint_inflammation2.29744147
16MP0004272_abnormal_basement_membrane2.23844353
17MP0006054_spinal_hemorrhage2.21671372
18MP0005623_abnormal_meninges_morphology2.16523082
19MP0003091_abnormal_cell_migration2.15776789
20MP0010030_abnormal_orbit_morphology2.14774770
21MP0009250_abnormal_appendicular_skeleto2.08998687
22MP0002282_abnormal_trachea_morphology2.07855974
23MP0004134_abnormal_chest_morphology2.06304908
24MP0005058_abnormal_lysosome_morphology1.95371612
25MP0005257_abnormal_intraocular_pressure1.90915946
26MP0004510_myositis1.88422940
27MP0002060_abnormal_skin_morphology1.82927009
28MP0002896_abnormal_bone_mineralization1.82697197
29MP0005390_skeleton_phenotype1.78792498
30MP0000163_abnormal_cartilage_morphology1.78456948
31MP0003011_delayed_dark_adaptation1.77169329
32MP0009780_abnormal_chondrocyte_physiolo1.67012640
33MP0001243_abnormal_dermal_layer1.65477764
34MP0001299_abnormal_eye_distance/1.63441688
35MP0001533_abnormal_skeleton_physiology1.59390802
36MP0002115_abnormal_skeleton_extremities1.55324347
37MP0003191_abnormal_cellular_cholesterol1.48432942
38* MP0002295_abnormal_pulmonary_circulatio1.46046476
39MP0002877_abnormal_melanocyte_morpholog1.45914701
40MP0002113_abnormal_skeleton_development1.43291102
41MP0002108_abnormal_muscle_morphology1.40653334
42MP0010368_abnormal_lymphatic_system1.39582907
43MP0003075_altered_response_to1.39108052
44MP0002998_abnormal_bone_remodeling1.33465945
45MP0003950_abnormal_plasma_membrane1.30222050
46MP0003385_abnormal_body_wall1.29830340
47MP0000750_abnormal_muscle_regeneration1.27299817
48MP0006082_CNS_inflammation1.26784826
49MP0003283_abnormal_digestive_organ1.24082141
50MP0000767_abnormal_smooth_muscle1.21646133
51MP0003795_abnormal_bone_structure1.20793895
52MP0001348_abnormal_lacrimal_gland1.20786248
53MP0004858_abnormal_nervous_system1.20504405
54MP0000733_abnormal_muscle_development1.19243554
55MP0003300_gastrointestinal_ulcer1.15687287
56MP0000013_abnormal_adipose_tissue1.12343345
57MP0003755_abnormal_palate_morphology1.09849880
58MP0002089_abnormal_postnatal_growth/wei1.08336869
59MP0008004_abnormal_stomach_pH1.05980501
60MP0000538_abnormal_urinary_bladder1.05139037
61MP0009053_abnormal_anal_canal1.03242551
62MP0005164_abnormal_response_to1.02179450
63MP0005166_decreased_susceptibility_to0.94764678
64MP0002168_other_aberrant_phenotype0.94333011
65MP0000858_altered_metastatic_potential0.93618317
66MP0002932_abnormal_joint_morphology0.92022822
67MP0002109_abnormal_limb_morphology0.91895563
68MP0002332_abnormal_exercise_endurance0.90323799
69MP0003942_abnormal_urinary_system0.89334714
70MP0000762_abnormal_tongue_morphology0.88503797
71MP0003436_decreased_susceptibility_to0.88065498
72MP0005595_abnormal_vascular_smooth0.87511875
73MP0003186_abnormal_redox_activity0.87356404
74MP0005076_abnormal_cell_differentiation0.87046183
75MP0003448_altered_tumor_morphology0.84152279
76MP0000049_abnormal_middle_ear0.83597059
77MP0001849_ear_inflammation0.81442603
78MP0009764_decreased_sensitivity_to0.79742111
79MP0003172_abnormal_lysosome_physiology0.79265635
80MP0000432_abnormal_head_morphology0.78902294
81MP0002111_abnormal_tail_morphology0.77786231
82MP0003045_fibrosis0.77451906
83MP0008260_abnormal_autophagy0.76599675
84MP0001879_abnormal_lymphatic_vessel0.75632982
85MP0002116_abnormal_craniofacial_bone0.75333084
86MP0000604_amyloidosis0.73274708
87* MP0001614_abnormal_blood_vessel0.70518649
88* MP0000343_altered_response_to0.69841971
89* MP0002128_abnormal_blood_circulation0.69227903
90MP0010386_abnormal_urinary_bladder0.68470415
91MP0001175_abnormal_lung_morphology0.68440770
92MP0000428_abnormal_craniofacial_morphol0.68369114
93MP0009785_altered_susceptibility_to0.67899765
94MP0000751_myopathy0.67494675
95MP0001915_intracranial_hemorrhage0.67042405
96MP0005197_abnormal_uvea_morphology0.66540032
97MP0001881_abnormal_mammary_gland0.65726609
98MP0008007_abnormal_cellular_replicative0.65218123
99MP0000003_abnormal_adipose_tissue0.64770542
100MP0005464_abnormal_platelet_physiology0.64582786
101MP0000759_abnormal_skeletal_muscle0.64139870
102MP0003115_abnormal_respiratory_system0.63292502
103MP0000749_muscle_degeneration0.63232194
104MP0001661_extended_life_span0.62726245
105MP0002148_abnormal_hypersensitivity_rea0.62356111
106* MP0000249_abnormal_blood_vessel0.62035284
107MP0005084_abnormal_gallbladder_morpholo0.61968224
108MP0003195_calcinosis0.61795370
109MP0003453_abnormal_keratinocyte_physiol0.61621850
110MP0000534_abnormal_ureter_morphology0.61184157
111MP0003828_pulmonary_edema0.60568082
112MP0002233_abnormal_nose_morphology0.59643283
113MP0002114_abnormal_axial_skeleton0.59419196
114MP0003937_abnormal_limbs/digits/tail_de0.59212690
115MP0004084_abnormal_cardiac_muscle0.58718790
116MP0003941_abnormal_skin_development0.58713192
117MP0003935_abnormal_craniofacial_develop0.57771969
118MP0004947_skin_inflammation0.57521540
119MP0002133_abnormal_respiratory_system0.55860797
120MP0005388_respiratory_system_phenotype0.55860797
121MP0004808_abnormal_hematopoietic_stem0.55807390
122MP0005367_renal/urinary_system_phenotyp0.55192576
123MP0000516_abnormal_urinary_system0.55192576
124MP0005193_abnormal_anterior_eye0.54932097
125MP0010771_integument_phenotype0.53982235
126MP0004883_abnormal_blood_vessel0.53513730
127MP0002925_abnormal_cardiovascular_devel0.52618516
128MP0004197_abnormal_fetal_growth/weight/0.50941301
129MP0003806_abnormal_nucleotide_metabolis0.50254468
130MP0001177_atelectasis0.49721950
131MP0005165_increased_susceptibility_to0.49210442
132MP0005621_abnormal_cell_physiology0.49122713
133MP0003303_peritoneal_inflammation0.48714730
134MP0000627_abnormal_mammary_gland0.48593500
135MP0001853_heart_inflammation0.47573110

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.52077289
2Premature rupture of membranes (HP:0001788)7.26753106
3Epiphyseal dysplasia (HP:0002656)4.42272971
4Neonatal short-limb short stature (HP:0008921)4.40378182
5Peritonitis (HP:0002586)4.36048520
6Soft skin (HP:0000977)4.09149795
7Cervical subluxation (HP:0003308)3.98394061
8Aortic dissection (HP:0002647)3.96634913
9Irregular epiphyses (HP:0010582)3.92953424
10Vertebral compression fractures (HP:0002953)3.92496787
11Slender build (HP:0001533)3.83368241
12Aortic aneurysm (HP:0004942)3.81200009
13Cupped ribs (HP:0000887)3.80698718
14Atrophic scars (HP:0001075)3.74087062
15Abnormality of dentin (HP:0010299)3.72931014
16Short middle phalanx of the 5th finger (HP:0004220)3.68391613
17Wormian bones (HP:0002645)3.62996640
18Biconcave vertebral bodies (HP:0004586)3.55032969
19Coxa vara (HP:0002812)3.52020138
20Dilatation of the ascending aorta (HP:0005111)3.45717516
21Vitreoretinal degeneration (HP:0000655)3.44048106
22Genu recurvatum (HP:0002816)3.36231630
23Hypoplastic ischia (HP:0003175)3.34270030
24Shallow orbits (HP:0000586)3.30505059
25Small epiphyses (HP:0010585)3.23762497
26Spondylolisthesis (HP:0003302)3.22523225
27Osteoarthritis (HP:0002758)3.15013173
28Blue sclerae (HP:0000592)3.13228095
29Bladder diverticulum (HP:0000015)3.12148446
30Ankle contracture (HP:0006466)3.09077181
31Mild short stature (HP:0003502)3.08838055
32Beaking of vertebral bodies (HP:0004568)3.07396881
33Fragile skin (HP:0001030)3.04100635
34Renal duplication (HP:0000075)3.02573198
35Abnormality of glycolipid metabolism (HP:0010969)3.01655174
36Abnormality of liposaccharide metabolism (HP:0010968)3.01655174
37Abnormality of glycosphingolipid metabolism (HP:0004343)3.01655174
38Abnormality of the acetabulum (HP:0003170)3.00214852
39Spinal rigidity (HP:0003306)2.98861642
40Flat capital femoral epiphysis (HP:0003370)2.96928893
41Metaphyseal cupping (HP:0003021)2.95210965
42Cerebral aneurysm (HP:0004944)2.92444637
43Flat acetabular roof (HP:0003180)2.91925920
44Abnormality of the ischium (HP:0003174)2.90312867
45Vascular tortuosity (HP:0004948)2.83595179
46Platyspondyly (HP:0000926)2.78053552
47Joint stiffness (HP:0001387)2.69150422
48Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.67818994
49Increased variability in muscle fiber diameter (HP:0003557)2.66771047
50Abnormal tarsal ossification (HP:0008369)2.62841380
51Overgrowth (HP:0001548)2.60289717
52Mitral stenosis (HP:0001718)2.58768496
53Dysostosis multiplex (HP:0000943)2.57412349
54Follicular hyperkeratosis (HP:0007502)2.56141671
55Flattened epiphyses (HP:0003071)2.55183245
56Mildly elevated creatine phosphokinase (HP:0008180)2.55012122
57Arterial tortuosity (HP:0005116)2.54471431
58Delayed epiphyseal ossification (HP:0002663)2.53602806
59Spinal cord compression (HP:0002176)2.52093558
60Short nail (HP:0001799)2.50270130
61Abnormal delivery (HP:0001787)2.49845319
62Genu varum (HP:0002970)2.48813832
63Increased connective tissue (HP:0009025)2.46990729
64Type 1 muscle fiber predominance (HP:0003803)2.46382256
65Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.44787072
66Radial bowing (HP:0002986)2.44126084
67Mitral valve prolapse (HP:0001634)2.44091052
68Abnormal vertebral ossification (HP:0100569)2.42564906
69Limited elbow extension (HP:0001377)2.40701110
70Ulnar bowing (HP:0003031)2.40538274
71Elbow flexion contracture (HP:0002987)2.36831339
72Mesomelia (HP:0003027)2.36187104
73Thoracolumbar scoliosis (HP:0002944)2.34602150
74Ectopia lentis (HP:0001083)2.33124089
75Myocardial infarction (HP:0001658)2.32229557
76Cardiovascular calcification (HP:0011915)2.31770734
77Abnormal foot bone ossification (HP:0010675)2.31239405
78Abnormality of mucopolysaccharide metabolism (HP:0011020)2.30765513
79Abnormality of polysaccharide metabolism (HP:0011012)2.30765513
80Abnormality of glycosaminoglycan metabolism (HP:0004371)2.30765513
81Abnormality of the proximal phalanges of the hand (HP:0009834)2.29677731
82Generalized amyotrophy (HP:0003700)2.29472309
83Mucopolysacchariduria (HP:0008155)2.27488539
84Urinary glycosaminoglycan excretion (HP:0003541)2.27488539
85Abnormality of skeletal muscle fiber size (HP:0012084)2.22067821
86Abnormality of the vertebral endplates (HP:0005106)2.20770913
87Absent frontal sinuses (HP:0002688)2.20335564
88Irregular vertebral endplates (HP:0003301)2.18491712
89Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.18166703
90Abnormality of femoral epiphyses (HP:0006499)2.18166703
91Achilles tendon contracture (HP:0001771)2.17508548
92Bowel diverticulosis (HP:0005222)2.16916780
93Upper limb amyotrophy (HP:0009129)2.16615849
94Distal upper limb amyotrophy (HP:0007149)2.16615849
95Abnormality of the calcaneus (HP:0008364)2.15447997
96Aortic valve stenosis (HP:0001650)2.15026296
97Wrist flexion contracture (HP:0001239)2.14908427
98Hyperextensible skin (HP:0000974)2.13977530
99Tibial bowing (HP:0002982)2.12714708
100Decreased skull ossification (HP:0004331)2.12573898
101Broad long bones (HP:0005622)2.11677503
102Long palpebral fissure (HP:0000637)2.11278473
103Systemic lupus erythematosus (HP:0002725)2.09846976
104Gingival overgrowth (HP:0000212)2.09483159
105Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.08679044
106Protruding ear (HP:0000411)2.08635506
107Infantile muscular hypotonia (HP:0008947)2.07686154
108Broad metatarsal (HP:0001783)2.07643935
109Osteolytic defects of the phalanges of the hand (HP:0009771)2.06941695
110Osteolytic defects of the hand bones (HP:0009699)2.06941695
111Reduced subcutaneous adipose tissue (HP:0003758)2.06449913
112Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.05752123
113Nuclear cataract (HP:0100018)2.04786116
114Ovoid vertebral bodies (HP:0003300)2.02678190
115Hand muscle atrophy (HP:0009130)2.02344808
116Abnormality of the Achilles tendon (HP:0005109)2.00267584
117Congenital glaucoma (HP:0001087)1.99637739
118Aortic regurgitation (HP:0001659)1.99556495
119Stillbirth (HP:0003826)1.99337282
120Delayed cranial suture closure (HP:0000270)1.99160433
121Abnormality of the distal phalanges of the toes (HP:0010182)1.98904897
122Abnormality of skull ossification (HP:0002703)1.98876522
123Abnormality of carpal bone ossification (HP:0006257)1.98636370
124Absent epiphyses (HP:0010577)1.98342195
125Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.98342195
126Breech presentation (HP:0001623)1.98200923
127Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.97976018
128Vertebral hypoplasia (HP:0008417)1.97976018
129Wide anterior fontanel (HP:0000260)1.97883969
130Vacuolated lymphocytes (HP:0001922)1.97736705
131Hypoplasia of the odontoid process (HP:0003311)1.96811161
132Thin ribs (HP:0000883)1.96298665
133Aneurysm (HP:0002617)1.95081859
134Natal tooth (HP:0000695)1.95032465
135Hypoventilation (HP:0002791)1.94313246
136Joint laxity (HP:0001388)1.93491297
137Hip contracture (HP:0003273)1.93264459
138Mitral regurgitation (HP:0001653)1.92488432
139Bowed forearm bones (HP:0003956)1.89698913
140Hypoalphalipoproteinemia (HP:0003233)1.89339599
141Abnormality of the right ventricle (HP:0001707)1.88946697
142Long toe (HP:0010511)1.85268267
143Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.83869567
144Inguinal hernia (HP:0000023)1.81031190
145Nonimmune hydrops fetalis (HP:0001790)1.80840082
146Prolonged neonatal jaundice (HP:0006579)1.80650557
147Delayed closure of the anterior fontanelle (HP:0001476)1.80012764
148Amyloidosis (HP:0011034)1.78795130
149J-shaped sella turcica (HP:0002680)1.78520414
150Axonal loss (HP:0003447)1.77232018

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.90346765
2LATS24.20791959
3TESK13.59059267
4IRAK33.17291443
5TTN3.05661434
6LIMK12.96111548
7TRIB32.82745077
8MAP3K32.79697450
9ERN12.57643488
10NME22.55685569
11PIM22.49197711
12TESK22.47677212
13RPS6KA42.15938135
14EPHA22.08777986
15LMTK22.03141265
16PDGFRA1.98395332
17TRPM71.97182500
18BUB11.96444471
19PRPF4B1.92782116
20ERBB31.92246520
21PAK21.92009622
22MOS1.86785563
23LATS11.83873381
24PIK3CG1.69717477
25PRKD21.55364195
26PRKG21.54951128
27EPHB21.53205587
28STK38L1.51571897
29PKN21.49614497
30EPHA31.45986572
31PAK31.44224230
32BMX1.43608896
33PTK21.39598081
34PBK1.33590240
35FER1.31015578
36LRRK21.26370929
37STK381.26229843
38MAP3K121.25706995
39ZAP701.25449102
40NEK91.21203532
41PTK2B1.20178712
42EIF2AK11.18386422
43MAPKAPK31.12546306
44MAP3K111.11127396
45TAOK11.10808953
46PAK41.07416728
47STK101.07177432
48PIK3CA1.05088597
49KIT1.04897073
50STK31.00903523
51ADRBK11.00226614
52PAK10.99643886
53STK160.98653569
54PLK20.95600429
55TAOK20.92314897
56MET0.92018781
57JAK10.91829020
58ROCK10.88728899
59TYK20.88303759
60GRK50.87859344
61SCYL20.86322363
62PDK20.84988510
63GRK70.84062076
64MAP2K30.83357626
65ABL20.83139456
66FGFR10.81217562
67MAP2K10.81197640
68MAP3K80.80786361
69ADRBK20.80700218
70ILK0.80281351
71KDR0.79124732
72AKT30.77124031
73GSK3A0.75469949
74EPHB10.75312343
75CLK10.72770283
76MAP3K60.69280458
77GRK10.69237734
78EIF2AK30.68628904
79RIPK10.67608844
80BRSK20.62841606
81JAK30.62441699
82HIPK20.60633058
83VRK20.59966690
84TBK10.59341940
85PTK60.56539574
86BRAF0.55196009
87STK240.55121000
88MYLK0.55089668
89CDK140.54973183
90MAP3K130.54082671
91ARAF0.53533853
92CAMKK20.53467385
93TGFBR10.52477423
94INSR0.50673013
95WEE10.50203823
96CDK150.49940850
97TGFBR20.49629549
98CDK180.46849838
99MTOR0.46404795
100FRK0.45972923
101CDC42BPA0.45449935
102DAPK30.45433966
103ERBB40.45109997
104MST1R0.44598420
105CDK11A0.43102452
106SIK10.41846783
107ROCK20.40783427
108MAP3K10.40522694
109IKBKE0.40473227
110PDGFRB0.40371597
111PRKD10.40202806
112PAK60.38055863
113MKNK10.37983547
114PRKD30.37899112
115PLK30.37162302
116CDK60.36159652
117NTRK10.35373000
118MAPKAPK20.34919538
119IKBKB0.34820126
120FLT30.34564268
121NEK10.34551955
122MAP3K140.34129943
123AURKA0.33558316
124MST40.33555047
125RPS6KB20.31581936
126BMPR20.30598357
127ABL10.30022585
128MAPK70.29930319
129MAP3K50.29279076
130DMPK0.28926148
131DAPK10.28498935
132AURKB0.27562191
133NME10.27437467
134CAMK2G0.26892161
135MAPK40.26689799
136NUAK10.25301955
137CHUK0.24749801
138RPS6KA20.23471399

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.95307670
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.86900558
3Focal adhesion_Homo sapiens_hsa045103.08231808
4Malaria_Homo sapiens_hsa051443.07927241
5Protein digestion and absorption_Homo sapiens_hsa049742.60339584
6Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.40185048
7Complement and coagulation cascades_Homo sapiens_hsa046102.37659084
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.25251255
9Proteoglycans in cancer_Homo sapiens_hsa052052.24445112
10Bladder cancer_Homo sapiens_hsa052192.19149743
11Shigellosis_Homo sapiens_hsa051312.13139676
12TGF-beta signaling pathway_Homo sapiens_hsa043502.09077938
13Mineral absorption_Homo sapiens_hsa049782.07707701
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.88428784
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.88075985
16Adherens junction_Homo sapiens_hsa045201.87392244
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.85104002
18Sulfur metabolism_Homo sapiens_hsa009201.81249317
19p53 signaling pathway_Homo sapiens_hsa041151.80182708
20Phagosome_Homo sapiens_hsa041451.75961899
21PI3K-Akt signaling pathway_Homo sapiens_hsa041511.68154164
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.68008643
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.61181549
24MicroRNAs in cancer_Homo sapiens_hsa052061.60333700
25Amoebiasis_Homo sapiens_hsa051461.58613630
26Dilated cardiomyopathy_Homo sapiens_hsa054141.58131919
27Hippo signaling pathway_Homo sapiens_hsa043901.49307662
28TNF signaling pathway_Homo sapiens_hsa046681.44467189
29Small cell lung cancer_Homo sapiens_hsa052221.42231077
30Proteasome_Homo sapiens_hsa030501.35952141
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.34853426
32Regulation of actin cytoskeleton_Homo sapiens_hsa048101.30924298
33Apoptosis_Homo sapiens_hsa042101.17331375
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14675624
35Protein export_Homo sapiens_hsa030601.11634686
36Salmonella infection_Homo sapiens_hsa051321.11217225
37Viral myocarditis_Homo sapiens_hsa054161.08601112
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06194918
39Legionellosis_Homo sapiens_hsa051341.02679116
40Rheumatoid arthritis_Homo sapiens_hsa053231.00871284
41Vibrio cholerae infection_Homo sapiens_hsa051101.00795843
42Melanoma_Homo sapiens_hsa052180.98492467
43Chronic myeloid leukemia_Homo sapiens_hsa052200.98385747
44Leukocyte transendothelial migration_Homo sapiens_hsa046700.96400660
45HTLV-I infection_Homo sapiens_hsa051660.87122932
46* HIF-1 signaling pathway_Homo sapiens_hsa040660.86240123
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85548684
48Pertussis_Homo sapiens_hsa051330.84927885
49Platelet activation_Homo sapiens_hsa046110.81328375
50Leishmaniasis_Homo sapiens_hsa051400.80045650
51Viral carcinogenesis_Homo sapiens_hsa052030.79480672
52Fructose and mannose metabolism_Homo sapiens_hsa000510.79298461
53Hepatitis B_Homo sapiens_hsa051610.78875004
54African trypanosomiasis_Homo sapiens_hsa051430.78584335
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76609899
56One carbon pool by folate_Homo sapiens_hsa006700.75726904
57Cell cycle_Homo sapiens_hsa041100.74981795
58Glutathione metabolism_Homo sapiens_hsa004800.74118209
59Rap1 signaling pathway_Homo sapiens_hsa040150.73634193
60Pancreatic cancer_Homo sapiens_hsa052120.72286499
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71742152
62Gap junction_Homo sapiens_hsa045400.70386597
63Pentose phosphate pathway_Homo sapiens_hsa000300.68903150
64N-Glycan biosynthesis_Homo sapiens_hsa005100.67244867
65Toxoplasmosis_Homo sapiens_hsa051450.64434049
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63988572
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.63460459
68Prostate cancer_Homo sapiens_hsa052150.63169798
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62764238
70Tight junction_Homo sapiens_hsa045300.62386952
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.61693186
72Pathways in cancer_Homo sapiens_hsa052000.61664819
73Hematopoietic cell lineage_Homo sapiens_hsa046400.60608527
74Other glycan degradation_Homo sapiens_hsa005110.59928165
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57920120
76Arachidonic acid metabolism_Homo sapiens_hsa005900.57225568
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56154248
78Influenza A_Homo sapiens_hsa051640.55863720
79RNA transport_Homo sapiens_hsa030130.53553021
80Lysosome_Homo sapiens_hsa041420.53212616
81Hedgehog signaling pathway_Homo sapiens_hsa043400.53018799
82Basal cell carcinoma_Homo sapiens_hsa052170.52690524
83Collecting duct acid secretion_Homo sapiens_hsa049660.52461776
84Arginine and proline metabolism_Homo sapiens_hsa003300.50144261
85Osteoclast differentiation_Homo sapiens_hsa043800.49603023
86Thyroid cancer_Homo sapiens_hsa052160.48980409
87Tuberculosis_Homo sapiens_hsa051520.48540527
88Ribosome_Homo sapiens_hsa030100.48359055
89Epstein-Barr virus infection_Homo sapiens_hsa051690.48329999
90Fatty acid elongation_Homo sapiens_hsa000620.47439672
91Hepatitis C_Homo sapiens_hsa051600.47052180
92Glioma_Homo sapiens_hsa052140.45697902
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45305441
94Galactose metabolism_Homo sapiens_hsa000520.44682983
95Prion diseases_Homo sapiens_hsa050200.43752212
96Staphylococcus aureus infection_Homo sapiens_hsa051500.43100643
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42632866
98Wnt signaling pathway_Homo sapiens_hsa043100.41832419
99Folate biosynthesis_Homo sapiens_hsa007900.41078440
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40771823
101Sulfur relay system_Homo sapiens_hsa041220.40683464
102Renal cell carcinoma_Homo sapiens_hsa052110.38932210
103Chemical carcinogenesis_Homo sapiens_hsa052040.38718688
104Steroid biosynthesis_Homo sapiens_hsa001000.38369906
105VEGF signaling pathway_Homo sapiens_hsa043700.38235404
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37967123
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37673143
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37577323
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36996195
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.36872045
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.36658463
112Ovarian steroidogenesis_Homo sapiens_hsa049130.36410260
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35773432
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33469036
115NF-kappa B signaling pathway_Homo sapiens_hsa040640.32359902
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32000466
117Colorectal cancer_Homo sapiens_hsa052100.31519833
118Endocytosis_Homo sapiens_hsa041440.31187069
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30894394
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30890156
121Ras signaling pathway_Homo sapiens_hsa040140.30864144
122Sphingolipid metabolism_Homo sapiens_hsa006000.30459527
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29938094
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29811744
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.29470306
126Renin-angiotensin system_Homo sapiens_hsa046140.29236729
127Measles_Homo sapiens_hsa051620.27665792
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25767248

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