TIMP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to leptin stimulus (GO:0044320)5.54713321
2response to leptin (GO:0044321)4.94775585
3fatty acid homeostasis (GO:0055089)4.88462612
4NADH metabolic process (GO:0006734)4.80676801
5gamma-aminobutyric acid transport (GO:0015812)4.64388473
6negative regulation of appetite (GO:0032099)4.46767183
7negative regulation of response to food (GO:0032096)4.46767183
8transcytosis (GO:0045056)4.44029071
9alanine transport (GO:0032328)4.32950880
10L-amino acid import (GO:0043092)4.31401920
11CDP-diacylglycerol biosynthetic process (GO:0016024)4.27770023
12alpha-linolenic acid metabolic process (GO:0036109)4.27762629
13amino acid import (GO:0043090)4.27027609
14glycerolipid catabolic process (GO:0046503)4.23502639
15cellular potassium ion homeostasis (GO:0030007)4.18827366
16lipid particle organization (GO:0034389)4.17328855
17CDP-diacylglycerol metabolic process (GO:0046341)4.08714513
18triglyceride biosynthetic process (GO:0019432)4.05828800
19L-serine transport (GO:0015825)4.03975572
20C4-dicarboxylate transport (GO:0015740)4.01938009
21ethanol oxidation (GO:0006069)3.93999507
22sodium ion export (GO:0071436)3.87882455
23neutral lipid biosynthetic process (GO:0046460)3.81689882
24acylglycerol biosynthetic process (GO:0046463)3.81689882
25locomotory exploration behavior (GO:0035641)3.77940793
26fatty-acyl-CoA biosynthetic process (GO:0046949)3.77561593
27diacylglycerol metabolic process (GO:0046339)3.70745369
28response to phenylpropanoid (GO:0080184)3.70282861
29valine metabolic process (GO:0006573)3.68881621
30protein heterotrimerization (GO:0070208)3.67729945
31thioester biosynthetic process (GO:0035384)3.64841120
32acyl-CoA biosynthetic process (GO:0071616)3.64841120
33cell communication by electrical coupling (GO:0010644)3.62732350
34polyol transport (GO:0015791)3.57910502
35positive regulation of fatty acid oxidation (GO:0046321)3.55942297
36lipid storage (GO:0019915)3.52552152
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.51689786
38fatty acid elongation (GO:0030497)3.47311596
39serine transport (GO:0032329)3.41984734
40cerebellar granule cell differentiation (GO:0021707)3.41068681
41fatty-acyl-CoA metabolic process (GO:0035337)3.40829700
42potassium ion import (GO:0010107)3.40450075
43positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.38037092
44triglyceride metabolic process (GO:0006641)3.37584984
45positive regulation of fatty acid beta-oxidation (GO:0032000)3.36800649
46regulation of response to food (GO:0032095)3.35860780
47phagocytosis, recognition (GO:0006910)3.31798726
48cellular sodium ion homeostasis (GO:0006883)3.31756238
49regulation of glycogen (starch) synthase activity (GO:2000465)3.30874954
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.30341225
51cGMP-mediated signaling (GO:0019934)3.27517682
52tricarboxylic acid metabolic process (GO:0072350)3.24961213
53neurotransmitter uptake (GO:0001504)3.24442988
54regulation of cAMP-dependent protein kinase activity (GO:2000479)3.21837066
55ethanol metabolic process (GO:0006067)3.20285170
56detection of calcium ion (GO:0005513)3.18051890
57oxaloacetate metabolic process (GO:0006107)3.17243796
58positive regulation of cholesterol efflux (GO:0010875)3.13867130
59neurotransmitter-gated ion channel clustering (GO:0072578)3.13713743
60negative regulation of astrocyte differentiation (GO:0048712)3.13123890
61acylglycerol metabolic process (GO:0006639)3.13024906
62long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.10772616
63fatty acid transmembrane transport (GO:1902001)3.07674639
64neutral lipid metabolic process (GO:0006638)3.07638388
65ionotropic glutamate receptor signaling pathway (GO:0035235)3.06994285
66positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.05411144
67hyperosmotic salinity response (GO:0042538)3.05303428
68positive regulation of lipid storage (GO:0010884)3.04167717
69low-density lipoprotein particle clearance (GO:0034383)3.03358234
70long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.01235524
71negative regulation of amino acid transport (GO:0051956)3.01166499
72thioester metabolic process (GO:0035383)3.00940280
73acyl-CoA metabolic process (GO:0006637)3.00940280
74primary alcohol metabolic process (GO:0034308)2.99979931
75response to dietary excess (GO:0002021)2.99630940
76regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.97556015
77glutamate receptor signaling pathway (GO:0007215)2.96367162
78regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.95897071
79proline transport (GO:0015824)2.94864934
80kidney mesenchyme development (GO:0072074)2.93494404
81potassium ion homeostasis (GO:0055075)2.91266314
82linoleic acid metabolic process (GO:0043651)2.90375869
83positive regulation of glomerulus development (GO:0090193)2.90141465
84regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.89986993
85plasma lipoprotein particle clearance (GO:0034381)2.89886809
86pattern specification involved in kidney development (GO:0061004)2.89165956
87positive regulation of sterol transport (GO:0032373)2.89111934
88positive regulation of cholesterol transport (GO:0032376)2.89111934
89response to nitrosative stress (GO:0051409)2.87081711
90G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.86845447
91neuron cell-cell adhesion (GO:0007158)2.86763998
92regulation of sequestering of triglyceride (GO:0010889)2.86637360
93cellular response to cadmium ion (GO:0071276)2.86420782
94negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.85355825
95ovulation from ovarian follicle (GO:0001542)2.84662509
96dermatan sulfate metabolic process (GO:0030205)2.81720627
97negative regulation of synaptic transmission, GABAergic (GO:0032229)2.80855053
98phosphatidic acid metabolic process (GO:0046473)2.79548500
99phosphatidic acid biosynthetic process (GO:0006654)2.79548500
100chondroitin sulfate catabolic process (GO:0030207)2.76607574
101retina vasculature morphogenesis in camera-type eye (GO:0061299)2.75965542
102dermatan sulfate biosynthetic process (GO:0030208)2.75901853
103regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.75431884
104primary alcohol catabolic process (GO:0034310)2.75424920
105positive regulation of vascular permeability (GO:0043117)2.73478565
106regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.73443836
107regulation of phospholipid biosynthetic process (GO:0071071)2.72605337
108white fat cell differentiation (GO:0050872)2.72148580
109synaptic transmission, glutamatergic (GO:0035249)2.71886963
110retinol metabolic process (GO:0042572)2.70832713
111negative regulation of DNA biosynthetic process (GO:2000279)2.70440018
112negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.69867916
113postsynaptic membrane organization (GO:0001941)2.69031912
114response to auditory stimulus (GO:0010996)2.68992975
115regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.67914729
116glycine transport (GO:0015816)2.67583730
117myelination in peripheral nervous system (GO:0022011)2.67395277
118peripheral nervous system axon ensheathment (GO:0032292)2.67395277
119regulation of gonadotropin secretion (GO:0032276)2.67123235
120central nervous system myelination (GO:0022010)2.66470727
121axon ensheathment in central nervous system (GO:0032291)2.66470727
122negative regulation of smooth muscle cell migration (GO:0014912)2.65823629
123regulation of short-term neuronal synaptic plasticity (GO:0048172)2.65654190
124regulation of membrane repolarization (GO:0060306)2.65553271
125protein localization to cell surface (GO:0034394)2.65388105
126regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.65341929
127vocalization behavior (GO:0071625)2.63917473
128neuronal action potential propagation (GO:0019227)2.63558071
129synaptic vesicle exocytosis (GO:0016079)2.63424333
130import into cell (GO:0098657)2.62603992
131tricarboxylic acid cycle (GO:0006099)2.62533817
132regulation of cell communication by electrical coupling (GO:0010649)2.60566074
133auditory behavior (GO:0031223)2.59771781
134cAMP biosynthetic process (GO:0006171)2.59702343
135positive regulation of cellular response to insulin stimulus (GO:1900078)2.58951297
136glomerular filtration (GO:0003094)2.58785809
137negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.57690641
138negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.57327269
139fatty acid beta-oxidation (GO:0006635)2.57184405
140acetyl-CoA metabolic process (GO:0006084)2.57148070
141regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.56677570
142acidic amino acid transport (GO:0015800)2.56609760
143brown fat cell differentiation (GO:0050873)2.56519758
144negative regulation of cytosolic calcium ion concentration (GO:0051481)2.55947892
145positive regulation of glycogen biosynthetic process (GO:0045725)2.55466671
146regulation of cilium movement (GO:0003352)2.54106561
147regulation of cardiac muscle cell contraction (GO:0086004)2.53078515
148regulation of phospholipase A2 activity (GO:0032429)2.51878455
149positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.50731025
150response to epinephrine (GO:0071871)2.50561740
151regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.50151448
152dendrite morphogenesis (GO:0048813)2.47276234
153biotin metabolic process (GO:0006768)2.46585457
154transmission of nerve impulse (GO:0019226)2.45954391
155positive regulation of potassium ion transmembrane transport (GO:1901381)2.45284535
156regulation of synaptic transmission, glutamatergic (GO:0051966)2.44643969
157positive regulation of cellular amide metabolic process (GO:0034250)2.43832465
158regulation of glutamate receptor signaling pathway (GO:1900449)2.42607384
159triglyceride catabolic process (GO:0019433)2.41898556
160cellular response to cholesterol (GO:0071397)2.41685583
161acylglycerol catabolic process (GO:0046464)2.40778463
162neutral lipid catabolic process (GO:0046461)2.40778463
163neurotransmitter secretion (GO:0007269)2.40488991
164positive regulation of macrophage cytokine production (GO:0060907)2.40195592
165regulation of fatty acid oxidation (GO:0046320)2.40189616
166layer formation in cerebral cortex (GO:0021819)2.39565805
167regulation of astrocyte differentiation (GO:0048710)2.37617328
168regulation of triglyceride biosynthetic process (GO:0010866)2.36089924
169regulation of beta-amyloid formation (GO:1902003)2.35697140
170regulation of synapse structural plasticity (GO:0051823)2.35158234
171negative regulation of sodium ion transport (GO:0010766)2.34333279
172positive regulation of triglyceride biosynthetic process (GO:0010867)2.34318165
173regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.31946737
174cellular response to epinephrine stimulus (GO:0071872)2.31200137
175atrial cardiac muscle cell action potential (GO:0086014)2.30089457
176low-density lipoprotein particle remodeling (GO:0034374)2.29698811
177regulation of cholesterol storage (GO:0010885)2.27467640
178positive regulation of glucose import (GO:0046326)2.27454169

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.52722994
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.16644055
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.14499474
4FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.87049836
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83597852
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.83553518
7GBX2_23144817_ChIP-Seq_PC3_Human2.82249911
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.74508835
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.64840205
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61707945
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61707945
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.61258118
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.58505462
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43154898
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.41338825
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.36542411
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27429665
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.24380930
19AR_21572438_ChIP-Seq_LNCaP_Human2.10380688
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06412896
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.02543572
22DROSHA_22980978_ChIP-Seq_HELA_Human1.96693842
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93349168
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.88958539
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.88923390
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.86125084
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82603193
28* TBX20_22080862_ChIP-Seq_HEART_Mouse1.76525195
29* TBX20_22328084_ChIP-Seq_HEART_Mouse1.76525195
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.76361969
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76346277
32LXR_22158963_ChIP-Seq_LIVER_Mouse1.75570930
33RXR_22158963_ChIP-Seq_LIVER_Mouse1.66777032
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.65699056
35* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.62359901
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61734457
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.57657606
38RXR_22108803_ChIP-Seq_LS180_Human1.55027604
39REST_21632747_ChIP-Seq_MESCs_Mouse1.51664868
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.48228336
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47948949
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47355648
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46746037
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46414528
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.44171184
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.44168728
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42900843
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40552891
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.38676326
50BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38662957
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37273274
52* SMAD4_21799915_ChIP-Seq_A2780_Human1.37229010
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36222982
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.35570922
55* AR_25329375_ChIP-Seq_VCAP_Human1.35242402
56* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33988635
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33501726
58* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.33288394
59KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32447466
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32447466
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32447466
62PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30703006
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.29450203
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.27634548
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27144489
66P300_19829295_ChIP-Seq_ESCs_Human1.25838160
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25154261
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24389125
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.23659120
70* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23420240
71BCAT_22108803_ChIP-Seq_LS180_Human1.21434786
72CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20257222
73CLOCK_20551151_ChIP-Seq_293T_Human1.19282636
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.19072405
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18330821
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.18317892
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17754445
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15075514
79NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14874563
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.14195252
81RARB_27405468_Chip-Seq_BRAIN_Mouse1.13750747
82TP53_18474530_ChIP-ChIP_U2OS_Human1.13044663
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12891238
84SA1_22415368_ChIP-Seq_MEFs_Mouse1.12543911
85NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11418717
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10973968
87TP53_20018659_ChIP-ChIP_R1E_Mouse1.10960507
88WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10225910
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09688535
90ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08965045
91AR_19668381_ChIP-Seq_PC3_Human1.08534718
92TP53_16413492_ChIP-PET_HCT116_Human1.07859779
93* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07510080
94STAT3_23295773_ChIP-Seq_U87_Human1.07380881
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07289862
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06459923
97RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04637974
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04388328
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02860002
100* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02429697
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02408947
102POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02176312
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.01711734
104SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00958505
105SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00081488
106EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98724891
107PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98648691
108NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97574185
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.97382642
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96952557
111CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95857678
112SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95837733
113ZNF274_21170338_ChIP-Seq_K562_Hela0.95686029
114NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95624675
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95624675
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95288502
117AHR_22903824_ChIP-Seq_MCF-7_Human0.94482507
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94426043
119POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94051117
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92801881
121RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92718282
122RUNX2_22187159_ChIP-Seq_PCA_Human0.91822384
123TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90991587
124SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90971605
125CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90924669
126RING1B_27294783_Chip-Seq_NPCs_Mouse0.90478021
127SMAD3_21741376_ChIP-Seq_HESCs_Human0.90112005
128* CJUN_26792858_Chip-Seq_BT549_Human0.89835779
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89224186
130TCF4_23295773_ChIP-Seq_U87_Human0.88302922
131PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88094120
132YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87874843
133EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87599391
134CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87356698
135ZNF263_19887448_ChIP-Seq_K562_Human0.86653832
136EOMES_21245162_ChIP-Seq_HESCs_Human0.85728946
137CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.84680837
138SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83943369
139TET1_21490601_ChIP-Seq_MESCs_Mouse0.82949350
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81433976
141STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80269880
142TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80225112
143POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80225112
144NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79516412
145VDR_22108803_ChIP-Seq_LS180_Human0.77789394
146NANOG_18692474_ChIP-Seq_MEFs_Mouse0.77086571
147SMC1_22415368_ChIP-Seq_MEFs_Mouse0.76202340
148SMC4_20622854_ChIP-Seq_HELA_Human0.75783650
149NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.75192939
150CBP_21632823_ChIP-Seq_H3396_Human0.74099665
151POU5F1_16518401_ChIP-PET_MESCs_Mouse0.72477727
152STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.72474842

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose4.32786857
2MP0004130_abnormal_muscle_cell3.49451666
3MP0003690_abnormal_glial_cell3.13443154
4MP0005666_abnormal_adipose_tissue2.68994741
5MP0004859_abnormal_synaptic_plasticity2.68167774
6MP0005503_abnormal_tendon_morphology2.58282829
7MP0009780_abnormal_chondrocyte_physiolo2.57002234
8MP0001501_abnormal_sleep_pattern2.51570621
9MP0003011_delayed_dark_adaptation2.36924053
10MP0009046_muscle_twitch2.31555056
11MP0000013_abnormal_adipose_tissue2.29752337
12MP0004885_abnormal_endolymph2.26172829
13MP0003635_abnormal_synaptic_transmissio2.21156517
14MP0004185_abnormal_adipocyte_glucose2.11244117
15MP0001486_abnormal_startle_reflex2.08195727
16MP0003186_abnormal_redox_activity1.99522055
17MP0002837_dystrophic_cardiac_calcinosis1.99408848
18MP0005375_adipose_tissue_phenotype1.94998871
19MP0002970_abnormal_white_adipose1.93624600
20MP0009745_abnormal_behavioral_response1.90754277
21MP0005423_abnormal_somatic_nervous1.88989665
22MP0005275_abnormal_skin_tensile1.87010971
23MP0003959_abnormal_lean_body1.82253195
24MP0003646_muscle_fatigue1.81027391
25MP0008569_lethality_at_weaning1.78780276
26* MP0004215_abnormal_myocardial_fiber1.76774603
27MP0002064_seizures1.76433059
28MP0000751_myopathy1.72279893
29MP0004270_analgesia1.71351634
30MP0004858_abnormal_nervous_system1.70381698
31MP0002272_abnormal_nervous_system1.70057209
32MP0002108_abnormal_muscle_morphology1.68020396
33MP0002063_abnormal_learning/memory/cond1.62925053
34MP0005377_hearing/vestibular/ear_phenot1.61388630
35MP0003878_abnormal_ear_physiology1.61388630
36MP0002572_abnormal_emotion/affect_behav1.61335675
37MP0002876_abnormal_thyroid_physiology1.60558670
38MP0003136_yellow_coat_color1.60250218
39MP0005646_abnormal_pituitary_gland1.58798039
40MP0001440_abnormal_grooming_behavior1.58699658
41MP0003880_abnormal_central_pattern1.56090108
42MP0002067_abnormal_sensory_capabilities1.54387568
43MP0002971_abnormal_brown_adipose1.51243867
44MP0005171_absent_coat_pigmentation1.50972831
45MP0003633_abnormal_nervous_system1.50183774
46MP0002254_reproductive_system_inflammat1.48665472
47MP0003329_amyloid_beta_deposits1.47538148
48MP0009384_cardiac_valve_regurgitation1.44938004
49MP0000003_abnormal_adipose_tissue1.44309384
50MP0006036_abnormal_mitochondrial_physio1.42388131
51MP0004084_abnormal_cardiac_muscle1.41194343
52MP0002734_abnormal_mechanical_nocicepti1.40334773
53MP0001502_abnormal_circadian_rhythm1.39438659
54MP0003279_aneurysm1.36772022
55MP0005452_abnormal_adipose_tissue1.34774396
56MP0002638_abnormal_pupillary_reflex1.32277254
57MP0005448_abnormal_energy_balance1.31206448
58MP0005385_cardiovascular_system_phenoty1.28456356
59MP0001544_abnormal_cardiovascular_syste1.28456356
60MP0009379_abnormal_foot_pigmentation1.28251831
61MP0002295_abnormal_pulmonary_circulatio1.28241557
62MP0005645_abnormal_hypothalamus_physiol1.28069254
63MP0005167_abnormal_blood-brain_barrier1.27765785
64MP0001485_abnormal_pinna_reflex1.27402144
65MP0001968_abnormal_touch/_nociception1.26959646
66MP0010368_abnormal_lymphatic_system1.25522039
67MP0002909_abnormal_adrenal_gland1.25020306
68MP0004145_abnormal_muscle_electrophysio1.23648708
69MP0002736_abnormal_nociception_after1.22893854
70MP0001881_abnormal_mammary_gland1.19616647
71MP0002733_abnormal_thermal_nociception1.18016914
72MP0003137_abnormal_impulse_conducting1.17620224
73MP0002090_abnormal_vision1.16368179
74MP0000759_abnormal_skeletal_muscle1.15857447
75MP0000747_muscle_weakness1.15336043
76MP0003634_abnormal_glial_cell1.15273445
77MP0010329_abnormal_lipoprotein_level1.14667787
78MP0005620_abnormal_muscle_contractility1.13551912
79MP0006138_congestive_heart_failure1.13468744
80MP0003950_abnormal_plasma_membrane1.12595502
81MP0008438_abnormal_cutaneous_collagen1.11752697
82MP0004272_abnormal_basement_membrane1.11618044
83MP0009115_abnormal_fat_cell1.11442535
84MP0003828_pulmonary_edema1.09136418
85MP0003631_nervous_system_phenotype1.09007289
86MP0004233_abnormal_muscle_weight1.08829247
87MP0004036_abnormal_muscle_relaxation1.08172362
88MP0005535_abnormal_body_temperature1.06828348
89MP0000778_abnormal_nervous_system1.05752771
90MP0005595_abnormal_vascular_smooth1.04414000
91MP0002557_abnormal_social/conspecific_i1.04198814
92MP0004924_abnormal_behavior1.03553509
93MP0005386_behavior/neurological_phenoty1.03553509
94MP0001970_abnormal_pain_threshold1.03061722
95MP0004147_increased_porphyrin_level1.01890317
96MP0001661_extended_life_span1.00127111
97MP0005379_endocrine/exocrine_gland_phen0.96825349
98MP0005334_abnormal_fat_pad0.95908861
99MP0000920_abnormal_myelination0.94435563
100MP0001727_abnormal_embryo_implantation0.94255351
101MP0002972_abnormal_cardiac_muscle0.94003108
102MP0004742_abnormal_vestibular_system0.93974824
103MP0000750_abnormal_muscle_regeneration0.93801762
104* MP0000343_altered_response_to0.93427022
105MP0004484_altered_response_of0.91214591
106MP0002078_abnormal_glucose_homeostasis0.90446449
107MP0003705_abnormal_hypodermis_morpholog0.90353394
108MP0006276_abnormal_autonomic_nervous0.90130286
109MP0004142_abnormal_muscle_tone0.89990784
110MP0001177_atelectasis0.89117793
111MP0005623_abnormal_meninges_morphology0.88833973
112MP0002066_abnormal_motor_capabilities/c0.87340349
113MP0005584_abnormal_enzyme/coenzyme_acti0.87001787
114MP0002118_abnormal_lipid_homeostasis0.85959270
115MP0008775_abnormal_heart_ventricle0.85900561
116MP0003075_altered_response_to0.85650780
117MP0005369_muscle_phenotype0.84159909
118MP0005164_abnormal_response_to0.82690943
119MP0005165_increased_susceptibility_to0.82350793
120MP0002133_abnormal_respiratory_system0.81561086
121MP0005388_respiratory_system_phenotype0.81561086
122MP0003868_abnormal_feces_composition0.79894920
123MP0000749_muscle_degeneration0.79684049
124MP0004087_abnormal_muscle_fiber0.77537273
125MP0005508_abnormal_skeleton_morphology0.77115123
126MP0001879_abnormal_lymphatic_vessel0.77037025
127MP0001963_abnormal_hearing_physiology0.76297175
128MP0002184_abnormal_innervation0.75843672
129MP0002089_abnormal_postnatal_growth/wei0.75682201
130MP0001299_abnormal_eye_distance/0.75486833
131MP0000604_amyloidosis0.74912038
132MP0004085_abnormal_heartbeat0.74898724
133MP0005647_abnormal_sex_gland0.74313973
134MP0001984_abnormal_olfaction0.74302822
135MP0001958_emphysema0.74066701
136MP0005551_abnormal_eye_electrophysiolog0.73384685
137MP0002269_muscular_atrophy0.70385635
138MP0005330_cardiomyopathy0.66607112
139MP0003879_abnormal_hair_cell0.66222522
140MP0000230_abnormal_systemic_arterial0.64619069

Predicted human phenotypes

RankGene SetZ-score
1Aplasia involving bones of the upper limbs (HP:0009823)6.34353761
2Aplasia of the phalanges of the hand (HP:0009802)6.34353761
3Aplasia involving bones of the extremities (HP:0009825)6.34353761
4Muscle fiber splitting (HP:0003555)4.58971411
5Focal motor seizures (HP:0011153)4.22884439
6Abnormality of secondary sexual hair (HP:0009888)4.13338718
7Abnormality of the axillary hair (HP:0100134)4.13338718
8Hemiplegia (HP:0002301)4.10492752
9Hemiparesis (HP:0001269)3.83968638
10Diplopia (HP:0000651)3.51057380
11Abnormality of binocular vision (HP:0011514)3.51057380
12Abnormality of skeletal muscle fiber size (HP:0012084)3.41022788
13Oligomenorrhea (HP:0000876)3.40907206
14Action tremor (HP:0002345)3.35703729
15Acanthosis nigricans (HP:0000956)3.35429560
16Exercise-induced myalgia (HP:0003738)3.30976486
17Bone cyst (HP:0012062)3.24774591
18Neck muscle weakness (HP:0000467)3.18862272
19Megalencephaly (HP:0001355)3.18643129
20Increased serum pyruvate (HP:0003542)3.12114934
21Polyphagia (HP:0002591)3.07878975
22Spinal rigidity (HP:0003306)3.04317966
23Insulin resistance (HP:0000855)3.02077711
24Increased muscle lipid content (HP:0009058)2.94100572
25Axonal loss (HP:0003447)2.94006445
26Short hallux (HP:0010109)2.93616169
27Protrusio acetabuli (HP:0003179)2.90365133
28Abnormality of glycolysis (HP:0004366)2.85247355
29Hyporeflexia of lower limbs (HP:0002600)2.84677831
30Focal seizures (HP:0007359)2.82073618
31Tetraparesis (HP:0002273)2.80964068
32Increased connective tissue (HP:0009025)2.78436646
33Neurofibrillary tangles (HP:0002185)2.76737583
34Progressive cerebellar ataxia (HP:0002073)2.75016587
35Skin nodule (HP:0200036)2.74005164
36Abnormality of the middle phalanges of the toes (HP:0010183)2.73572323
37Difficulty running (HP:0009046)2.73251373
38Hypoplastic left heart (HP:0004383)2.73100739
39Hypoalphalipoproteinemia (HP:0003233)2.71708176
40Potter facies (HP:0002009)2.70186309
41Facial shape deformation (HP:0011334)2.70186309
42Myokymia (HP:0002411)2.69532043
43Dysdiadochokinesis (HP:0002075)2.65548978
44Abnormal eating behavior (HP:0100738)2.65493945
45Fibular aplasia (HP:0002990)2.64152519
46Aplasia/Hypoplasia of the hallux (HP:0008362)2.62950255
47Complement deficiency (HP:0004431)2.57903643
48Onycholysis (HP:0001806)2.51901853
49Lipoatrophy (HP:0100578)2.50516816
50Humeroradial synostosis (HP:0003041)2.43168810
51Synostosis involving the elbow (HP:0003938)2.43168810
52Growth hormone excess (HP:0000845)2.42504521
53Polar cataract (HP:0010696)2.41857660
54Adactyly (HP:0009776)2.41238073
55Prominent supraorbital ridges (HP:0000336)2.39664910
56Broad metatarsal (HP:0001783)2.38944361
57Type 1 muscle fiber predominance (HP:0003803)2.35838790
58Hyperglycinuria (HP:0003108)2.32579509
59Foot dorsiflexor weakness (HP:0009027)2.29681355
60Bundle branch block (HP:0011710)2.28913972
61Rimmed vacuoles (HP:0003805)2.27992489
62Hypercortisolism (HP:0001578)2.26822240
63Generalized tonic-clonic seizures (HP:0002069)2.26341497
64Epileptic encephalopathy (HP:0200134)2.25800840
65Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.25509045
66Visual hallucinations (HP:0002367)2.24782554
67Abnormal atrioventricular conduction (HP:0005150)2.24466044
68Abnormality of the foot musculature (HP:0001436)2.24298722
69Abnormality of the phalanges of the 2nd finger (HP:0009541)2.24169582
70Heart block (HP:0012722)2.23869872
71Hypertriglyceridemia (HP:0002155)2.23740354
72Maternal diabetes (HP:0009800)2.23354187
73Absent hair (HP:0002298)2.21952636
74Myoglobinuria (HP:0002913)2.19130176
75Intention tremor (HP:0002080)2.18341476
76Bradycardia (HP:0001662)2.18070624
77Aplasia/Hypoplasia of the fibula (HP:0006492)2.17204668
78Myocardial infarction (HP:0001658)2.16895038
79Gowers sign (HP:0003391)2.16587234
80Subcapsular cataract (HP:0000523)2.11641398
81Rhabdomyolysis (HP:0003201)2.11347201
82Myotonia (HP:0002486)2.10814503
83Rhinitis (HP:0012384)2.10590542
84Opisthotonus (HP:0002179)2.10157101
85Back pain (HP:0003418)2.08707970
86Cerebral inclusion bodies (HP:0100314)2.08173188
87EMG: myopathic abnormalities (HP:0003458)2.07766277
88Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.06715508
89Frequent falls (HP:0002359)2.06693760
90Retinal atrophy (HP:0001105)2.06277363
91Epidermoid cyst (HP:0200040)2.05337056
92Ketoacidosis (HP:0001993)2.03668129
93Dysmetria (HP:0001310)2.01122124
94Reduced subcutaneous adipose tissue (HP:0003758)2.00984797
95Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.00539802
96Decreased activity of mitochondrial respiratory chain (HP:0008972)2.00539802
97Hypoplastic heart (HP:0001961)1.99506633
98Ectopia lentis (HP:0001083)1.99435574
99Long nose (HP:0003189)1.99423739
100Postural instability (HP:0002172)1.98935676
101Turricephaly (HP:0000262)1.97864481
102Abnormality of complement system (HP:0005339)1.95146902
103Atrial fibrillation (HP:0005110)1.94686910
104Exercise-induced muscle cramps (HP:0003710)1.90771177
105Gaze-evoked nystagmus (HP:0000640)1.90740683
106Increased variability in muscle fiber diameter (HP:0003557)1.90538537
107Truncal ataxia (HP:0002078)1.89297578
108Scanning speech (HP:0002168)1.88677893
109Muscle stiffness (HP:0003552)1.88196646
110Absent toe (HP:0010760)1.88183189
111Supranuclear gaze palsy (HP:0000605)1.88003785
112Abnormality of serine family amino acid metabolism (HP:0010894)1.86864601
113Abnormality of glycine metabolism (HP:0010895)1.86864601
114Respiratory insufficiency due to muscle weakness (HP:0002747)1.86785841
115Clumsiness (HP:0002312)1.86765119
116Limb-girdle muscle weakness (HP:0003325)1.86508023
117Large hands (HP:0001176)1.86188155
118Broad hallux (HP:0010055)1.85593017
119Insulin-resistant diabetes mellitus (HP:0000831)1.85507202
120Narrow nasal bridge (HP:0000446)1.85244314
121Shallow orbits (HP:0000586)1.85051926
122Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.83687088
123Hyperventilation (HP:0002883)1.82769994
124Tetraplegia (HP:0002445)1.82039429
125Long foot (HP:0001833)1.81613810
126Mixed hearing impairment (HP:0000410)1.81591922
127Gait imbalance (HP:0002141)1.81575569
128Infantile muscular hypotonia (HP:0008947)1.81506524
129Atonic seizures (HP:0010819)1.80928368
130Poor eye contact (HP:0000817)1.80151100
131Asymmetric septal hypertrophy (HP:0001670)1.80069091
132Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.80017706
133Spastic diplegia (HP:0001264)1.79889886
134Nausea (HP:0002018)1.79742301
135Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.79327170
136Febrile seizures (HP:0002373)1.79292340
137Dysmetric saccades (HP:0000641)1.77246061
138Abnormality of nail color (HP:0100643)1.77094599
139Absent/shortened dynein arms (HP:0200106)1.76846357
140Dynein arm defect of respiratory motile cilia (HP:0012255)1.76846357
141Dilated cardiomyopathy (HP:0001644)1.76610160
142Metaphyseal dysplasia (HP:0100255)1.76446719
143Amyloidosis (HP:0011034)1.76350265
144Vertebral compression fractures (HP:0002953)1.76333913
145Tubulointerstitial fibrosis (HP:0005576)1.76172496
146Prolonged QT interval (HP:0001657)1.74786514
147Broad foot (HP:0001769)1.74187479
148Xanthomatosis (HP:0000991)1.73720783
149Impaired vibration sensation in the lower limbs (HP:0002166)1.73325623
150Primary atrial arrhythmia (HP:0001692)1.73271568
151Thyroid-stimulating hormone excess (HP:0002925)1.73105427
152Pheochromocytoma (HP:0002666)1.72867636
153Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.72132051
154Lower limb muscle weakness (HP:0007340)1.71966706
155Hypoglycemic coma (HP:0001325)1.71561031
156Hypercholesterolemia (HP:0003124)1.71503546
157Broad-based gait (HP:0002136)1.69885232
158Abnormal urine output (HP:0012590)1.69682524
159Accelerated skeletal maturation (HP:0005616)1.69608800
160Aortic aneurysm (HP:0004942)1.69593210
161Atrioventricular block (HP:0001678)1.69384312
162Prenatal maternal abnormality (HP:0002686)1.68783669
163Sudden death (HP:0001699)1.68729266
164Abnormal social behavior (HP:0012433)1.68725644
165Impaired social interactions (HP:0000735)1.68725644
166Supraventricular arrhythmia (HP:0005115)1.67954647
167Scapular winging (HP:0003691)1.67385778
168Muscle fiber inclusion bodies (HP:0100299)1.67097793
169Hyperlipoproteinemia (HP:0010980)1.67007189
170Anxiety (HP:0000739)1.66706162
171Chronic bronchitis (HP:0004469)1.65995304
172Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.65617811
173Abnormal drinking behavior (HP:0030082)1.65303076
174Polydipsia (HP:0001959)1.65303076

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.43802125
2MUSK3.90159616
3LMTK23.41423167
4PHKG23.40519965
5PHKG13.40519965
6TRIB33.13699991
7CAMK1D2.86199235
8CAMK1G2.56899617
9NTRK22.51984186
10ERBB42.50011380
11CASK2.42355448
12MAPK152.29646430
13DDR22.27709495
14SIK12.27520728
15NTRK32.21826169
16EPHA42.21070271
17ABL22.14853763
18LATS21.77012827
19TTK1.65810624
20TESK11.65497453
21MAP3K41.64806936
22ARAF1.63857553
23RIPK11.54115764
24TGFBR21.53715206
25TYRO31.48684271
26PNCK1.45376269
27PRKD31.40040701
28EPHB11.39732591
29INSRR1.39481791
30MAP2K71.37015039
31MAPKAPK31.33468417
32PRKAA21.32101857
33MAPK121.30773854
34PINK11.29000888
35TSSK61.26499128
36TIE11.25526815
37PBK1.23843586
38EPHA31.20400094
39CAMKK21.20207251
40NTRK11.18186024
41STK38L1.16469043
42MAPK41.13522100
43MAP2K41.12804142
44MYLK1.10660143
45EPHB21.09388184
46GRK51.08572044
47FES1.05043928
48MAPK131.04465236
49MOS1.01545674
50PDK20.98342806
51RIPK40.98122714
52SGK20.97320943
53MINK10.97213856
54STK160.97042958
55CAMK10.96148579
56PRKCG0.95450718
57PRPF4B0.94462566
58MARK10.94019074
59PTK20.91404988
60SGK2230.91100871
61SGK4940.91100871
62NLK0.88119045
63PDGFRA0.86520450
64PIK3CA0.86274315
65DAPK20.85577457
66STK380.85037396
67BCKDK0.84166410
68DMPK0.83570866
69FGFR20.81636539
70CDK50.81056411
71ROCK10.79932187
72PRKCH0.79458566
73PDK30.79362174
74PDK40.79362174
75CAMKK10.78641441
76GSK3A0.78494604
77SGK30.77354121
78AKT20.75732768
79PAK20.74721681
80PAK60.73344931
81NME10.71532158
82PRKAA10.70793369
83NEK90.69380617
84CAMK2A0.67163225
85IGF1R0.67036466
86TTN0.66725821
87PDPK10.65995252
88OBSCN0.65944557
89MAPK70.65897480
90PRKCE0.65731515
91OXSR10.63159769
92FER0.62911088
93MAP3K130.60574062
94MAPKAPK50.60320820
95TRPM70.59392505
96PRKACB0.58392367
97STK390.58182900
98SGK10.58137325
99CAMK2G0.57939803
100PTK2B0.57567146
101ADRBK10.57560332
102PRKG10.56988332
103ROCK20.56917098
104BMX0.55752231
105PDGFRB0.55286775
106TNK20.54288261
107PRKD10.54283244
108PAK40.53855739
109PRKACG0.53031737
110CAMK40.52991519
111GRK70.51778310
112WNK10.51516351
113RPS6KA30.50629552
114PDK10.50367421
115NEK60.49690866
116SRC0.49045146
117MAP3K60.48820366
118PRKACA0.47749558
119PKN10.47553707
120CDC42BPA0.47338518
121KSR20.47288625
122FGFR30.47127151
123BRAF0.45164186
124CAMK2D0.44545133
125MAP3K90.43420326
126MAP2K10.42370855
127PAK30.42013818
128CDK60.41969290
129LIMK10.41431729
130RET0.41015407
131PRKCA0.40382795
132CAMK2B0.40145605
133CDK30.40074430
134STK110.39843857
135IRAK20.38667157
136MARK20.38368084
137FGR0.37434426

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.33055937
2Nitrogen metabolism_Homo sapiens_hsa009104.15900988
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.83120843
4PPAR signaling pathway_Homo sapiens_hsa033202.39411183
5Nicotine addiction_Homo sapiens_hsa050332.33121660
6Phenylalanine metabolism_Homo sapiens_hsa003602.33007872
7Fatty acid metabolism_Homo sapiens_hsa012122.32882149
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.22212654
9Histidine metabolism_Homo sapiens_hsa003402.03527391
10Propanoate metabolism_Homo sapiens_hsa006401.95449937
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.93512336
12GABAergic synapse_Homo sapiens_hsa047271.90706155
13Glutamatergic synapse_Homo sapiens_hsa047241.90504034
14Salivary secretion_Homo sapiens_hsa049701.78394308
15Fatty acid degradation_Homo sapiens_hsa000711.74183426
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.70961876
17Circadian entrainment_Homo sapiens_hsa047131.64610913
18Tyrosine metabolism_Homo sapiens_hsa003501.63735804
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.62590712
20Morphine addiction_Homo sapiens_hsa050321.54281822
21Adipocytokine signaling pathway_Homo sapiens_hsa049201.49945331
22Renin secretion_Homo sapiens_hsa049241.49122973
23Gastric acid secretion_Homo sapiens_hsa049711.44305932
24Glycerolipid metabolism_Homo sapiens_hsa005611.34794451
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33558583
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32182366
27Tryptophan metabolism_Homo sapiens_hsa003801.28643882
28Calcium signaling pathway_Homo sapiens_hsa040201.28073581
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.25903554
30Glutathione metabolism_Homo sapiens_hsa004801.24514936
31Fat digestion and absorption_Homo sapiens_hsa049751.24287750
32Sulfur relay system_Homo sapiens_hsa041221.23491424
33cAMP signaling pathway_Homo sapiens_hsa040241.21408846
34Long-term depression_Homo sapiens_hsa047301.21139319
35Circadian rhythm_Homo sapiens_hsa047101.17593976
36Insulin secretion_Homo sapiens_hsa049111.16870569
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16277433
38Long-term potentiation_Homo sapiens_hsa047201.15656847
39Taste transduction_Homo sapiens_hsa047421.12303567
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10910600
41Cardiac muscle contraction_Homo sapiens_hsa042601.08436020
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.06045563
43Arginine and proline metabolism_Homo sapiens_hsa003301.01718124
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00973446
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99047149
46Dilated cardiomyopathy_Homo sapiens_hsa054140.97679894
47Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97088310
48Olfactory transduction_Homo sapiens_hsa047400.96821332
49Amphetamine addiction_Homo sapiens_hsa050310.96050173
50Cholinergic synapse_Homo sapiens_hsa047250.94886794
51Proteasome_Homo sapiens_hsa030500.94215672
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93523783
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92491093
54Synaptic vesicle cycle_Homo sapiens_hsa047210.90579264
55Type II diabetes mellitus_Homo sapiens_hsa049300.88933095
56Pancreatic secretion_Homo sapiens_hsa049720.85770093
57Folate biosynthesis_Homo sapiens_hsa007900.85703857
58Bile secretion_Homo sapiens_hsa049760.85440924
59Dopaminergic synapse_Homo sapiens_hsa047280.85238050
60Oxytocin signaling pathway_Homo sapiens_hsa049210.84404585
61Cocaine addiction_Homo sapiens_hsa050300.84014321
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83553883
63Oxidative phosphorylation_Homo sapiens_hsa001900.82821445
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82727165
65Parkinsons disease_Homo sapiens_hsa050120.82019366
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80868615
67Dorso-ventral axis formation_Homo sapiens_hsa043200.78482813
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77912214
69AMPK signaling pathway_Homo sapiens_hsa041520.76701950
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.75961536
71Serotonergic synapse_Homo sapiens_hsa047260.74675982
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72927835
73Insulin resistance_Homo sapiens_hsa049310.72450166
74Thyroid hormone synthesis_Homo sapiens_hsa049180.71228907
75Gap junction_Homo sapiens_hsa045400.70099197
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69547247
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68960909
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.68902628
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68308792
80Glucagon signaling pathway_Homo sapiens_hsa049220.67667335
81Pyruvate metabolism_Homo sapiens_hsa006200.67273296
82Biosynthesis of amino acids_Homo sapiens_hsa012300.66413058
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65803966
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65242895
85Fatty acid elongation_Homo sapiens_hsa000620.64614650
86Butanoate metabolism_Homo sapiens_hsa006500.64541424
87Arginine biosynthesis_Homo sapiens_hsa002200.64284377
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62952587
89GnRH signaling pathway_Homo sapiens_hsa049120.60768775
90ECM-receptor interaction_Homo sapiens_hsa045120.59390854
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.59258738
92Estrogen signaling pathway_Homo sapiens_hsa049150.58598954
93Lysine degradation_Homo sapiens_hsa003100.57603105
94Ovarian steroidogenesis_Homo sapiens_hsa049130.57525349
95Huntingtons disease_Homo sapiens_hsa050160.57121224
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56683245
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55301367
98Peroxisome_Homo sapiens_hsa041460.55285407
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53884747
100Insulin signaling pathway_Homo sapiens_hsa049100.53730139
101Carbon metabolism_Homo sapiens_hsa012000.52818463
102Melanogenesis_Homo sapiens_hsa049160.51695628
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51544925
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50993872
105Choline metabolism in cancer_Homo sapiens_hsa052310.50352596
106Chemical carcinogenesis_Homo sapiens_hsa052040.49192699
107Mineral absorption_Homo sapiens_hsa049780.48494832
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48246647
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48217220
110beta-Alanine metabolism_Homo sapiens_hsa004100.46179404
111Renin-angiotensin system_Homo sapiens_hsa046140.44977229
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44901887
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.44357898
114Basal cell carcinoma_Homo sapiens_hsa052170.43498798
115Focal adhesion_Homo sapiens_hsa045100.43476753
116Sphingolipid metabolism_Homo sapiens_hsa006000.42164084
117Alzheimers disease_Homo sapiens_hsa050100.41908152
118Axon guidance_Homo sapiens_hsa043600.41448393
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.41042321
120One carbon pool by folate_Homo sapiens_hsa006700.40487762
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39948696
122Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39288459
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38599429
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38310488
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37931159
126Galactose metabolism_Homo sapiens_hsa000520.37775828
127Protein digestion and absorption_Homo sapiens_hsa049740.37429670
128Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37365954
129Retinol metabolism_Homo sapiens_hsa008300.37087535
130Rap1 signaling pathway_Homo sapiens_hsa040150.35460406
131Vitamin B6 metabolism_Homo sapiens_hsa007500.34854067
132African trypanosomiasis_Homo sapiens_hsa051430.34679944
133Tight junction_Homo sapiens_hsa045300.31260986
134Metabolic pathways_Homo sapiens_hsa011000.30123467
135Pentose phosphate pathway_Homo sapiens_hsa000300.29816766

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »