TINAG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman's capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis, membranous nephropathy and anti-glomerular basement membrane nephritis. Ontogeny studies suggest that the expression of this antigen is developmentally regulated in a precise spatial and temporal pattern throughout nephrogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)9.03317401
2urate metabolic process (GO:0046415)9.02526911
3aminoglycoside antibiotic metabolic process (GO:0030647)8.55835820
4phosphate ion transport (GO:0006817)8.48632545
5regulation of guanylate cyclase activity (GO:0031282)8.22632260
6angiotensin maturation (GO:0002003)7.74409249
7phosphate ion transmembrane transport (GO:0035435)7.73690130
8drug transport (GO:0015893)7.67002828
9cellular glucuronidation (GO:0052695)7.54870907
10lysine metabolic process (GO:0006553)7.54482897
11lysine catabolic process (GO:0006554)7.54482897
12positive regulation of guanylate cyclase activity (GO:0031284)7.26313844
13glucuronate metabolic process (GO:0019585)7.23718956
14uronic acid metabolic process (GO:0006063)7.23718956
15regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.12364020
16organic cation transport (GO:0015695)7.12123308
17regulation of bile acid biosynthetic process (GO:0070857)6.46165813
18cysteine metabolic process (GO:0006534)6.40660484
19drug catabolic process (GO:0042737)6.18075717
20epoxygenase P450 pathway (GO:0019373)6.09659546
21flavonoid metabolic process (GO:0009812)5.77690274
22peptide catabolic process (GO:0043171)5.74285387
23glyoxylate metabolic process (GO:0046487)5.73443992
24intestinal absorption (GO:0050892)5.72433027
25exogenous drug catabolic process (GO:0042738)5.69472434
26surfactant homeostasis (GO:0043129)5.61331313
27quaternary ammonium group transport (GO:0015697)5.60282550
28excretion (GO:0007588)5.47407976
29lipoprotein transport (GO:0042953)5.45986201
30branched-chain amino acid metabolic process (GO:0009081)5.44250834
31homocysteine metabolic process (GO:0050667)5.40438246
32regulation of cGMP biosynthetic process (GO:0030826)5.39718925
33response to mercury ion (GO:0046689)5.36297285
34bile acid and bile salt transport (GO:0015721)5.24004123
35tricarboxylic acid metabolic process (GO:0072350)5.23683247
36aspartate family amino acid catabolic process (GO:0009068)5.19358330
37nonribosomal peptide biosynthetic process (GO:0019184)5.15097938
38short-chain fatty acid metabolic process (GO:0046459)5.13410213
39renal absorption (GO:0070293)5.09559821
40vitamin D metabolic process (GO:0042359)5.05068929
41valine metabolic process (GO:0006573)5.02343733
42branched-chain amino acid catabolic process (GO:0009083)4.75738814
43regulation of systemic arterial blood pressure by hormone (GO:0001990)4.73296852
44regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.73296852
45endocrine process (GO:0050886)4.73296852
46trivalent inorganic anion homeostasis (GO:0072506)4.71304866
47phosphate ion homeostasis (GO:0055062)4.71304866
48positive regulation of cGMP biosynthetic process (GO:0030828)4.65140263
49toxin transport (GO:1901998)4.58908163
50glutathione biosynthetic process (GO:0006750)4.56094764
51proline metabolic process (GO:0006560)4.53955615
52L-phenylalanine metabolic process (GO:0006558)4.49530270
53erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.49530270
54chemical homeostasis within a tissue (GO:0048875)4.48952575
55fat-soluble vitamin biosynthetic process (GO:0042362)4.48743600
56calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.47868679
57cellular ketone body metabolic process (GO:0046950)4.45619721
58metanephric nephron tubule development (GO:0072234)4.45141945
59metanephric tubule development (GO:0072170)4.45141945
60erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.43734508
61L-phenylalanine catabolic process (GO:0006559)4.43734508
62hormone catabolic process (GO:0042447)4.43288078
63modified amino acid transport (GO:0072337)4.41920659
64regulation of cGMP metabolic process (GO:0030823)4.38840323
65cellular modified amino acid catabolic process (GO:0042219)4.32141518
66urea metabolic process (GO:0019627)4.31048132
67urea cycle (GO:0000050)4.27814627
68fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.27566952
69serine family amino acid metabolic process (GO:0009069)4.23574916
70fatty acid beta-oxidation (GO:0006635)4.22739493
71aromatic amino acid family catabolic process (GO:0009074)4.22714244
72regulation of triglyceride catabolic process (GO:0010896)4.16038515
73metanephric nephron epithelium development (GO:0072243)4.12746731
74bile acid metabolic process (GO:0008206)4.11870107
75receptor guanylyl cyclase signaling pathway (GO:0007168)4.11667598
76sulfate transmembrane transport (GO:1902358)4.11098050
77amino-acid betaine transport (GO:0015838)4.01964880
78carnitine transport (GO:0015879)4.01964880
79indole-containing compound catabolic process (GO:0042436)3.98773117
80indolalkylamine catabolic process (GO:0046218)3.98773117
81tryptophan catabolic process (GO:0006569)3.98773117
82nitrogen cycle metabolic process (GO:0071941)3.98690417
83positive regulation of cGMP metabolic process (GO:0030825)3.97690408
84regulation of systemic arterial blood pressure (GO:0003073)3.96449839
85serine family amino acid catabolic process (GO:0009071)3.94400948
86glycosylceramide metabolic process (GO:0006677)3.85521044
872-oxoglutarate metabolic process (GO:0006103)3.85015293
88fatty acid oxidation (GO:0019395)3.81861518
89amino-acid betaine metabolic process (GO:0006577)3.80918261
90ketone body metabolic process (GO:1902224)3.80855130
91glycoside metabolic process (GO:0016137)3.78841733
92tryptophan metabolic process (GO:0006568)3.78380291
93serine family amino acid biosynthetic process (GO:0009070)3.76462821
94sulfur amino acid catabolic process (GO:0000098)3.75123334
95glycosphingolipid catabolic process (GO:0046479)3.74402829
96lipid oxidation (GO:0034440)3.73564767
97metanephric epithelium development (GO:0072207)3.71451275
98peptide biosynthetic process (GO:0043043)3.69379061
99response to phenylpropanoid (GO:0080184)3.66736513
100glycolipid catabolic process (GO:0019377)3.65908610
101fructose metabolic process (GO:0006000)3.64493865
102sodium-independent organic anion transport (GO:0043252)3.62284478
103renal system process involved in regulation of blood volume (GO:0001977)3.62155882
104response to growth hormone (GO:0060416)3.60735683
105nephron tubule development (GO:0072080)3.58920555
106maintenance of gastrointestinal epithelium (GO:0030277)3.58590747
107fatty acid catabolic process (GO:0009062)3.55686197
108positive regulation of digestive system process (GO:0060456)3.53853316
109cobalamin metabolic process (GO:0009235)3.52167330
110cellular amino acid catabolic process (GO:0009063)3.51304893
111transepithelial transport (GO:0070633)3.49659450
112response to thyroid hormone (GO:0097066)3.49255905
113acetyl-CoA metabolic process (GO:0006084)3.47507313
114carnitine metabolic process (GO:0009437)3.45604567
115glutathione metabolic process (GO:0006749)3.44696271
116ethanol oxidation (GO:0006069)3.44346482
117biotin metabolic process (GO:0006768)3.43463712
118regulation of cellular extravasation (GO:0002691)3.43393491
119positive regulation of lipid catabolic process (GO:0050996)3.38567374
120glutathione derivative metabolic process (GO:1901685)3.38433145
121glutathione derivative biosynthetic process (GO:1901687)3.38433145
122positive regulation of systemic arterial blood pressure (GO:0003084)3.38285440
123sphingomyelin metabolic process (GO:0006684)3.34472034
124sulfate transport (GO:0008272)3.33293148
125glutamate metabolic process (GO:0006536)3.33160253
126regulation of cholesterol homeostasis (GO:2000188)3.33111507
127drug metabolic process (GO:0017144)3.32933944
128NADH metabolic process (GO:0006734)3.32891058
129nephron epithelium morphogenesis (GO:0072088)3.30286596
130nephron tubule morphogenesis (GO:0072078)3.30286596
131vitamin transport (GO:0051180)3.30168764
132digestion (GO:0007586)3.30060088
133cGMP biosynthetic process (GO:0006182)3.29966582
134virion attachment to host cell (GO:0019062)3.29096674
135adhesion of symbiont to host cell (GO:0044650)3.29096674
136alpha-amino acid catabolic process (GO:1901606)3.27437648
137very-low-density lipoprotein particle assembly (GO:0034379)3.26943659
138negative regulation of steroid metabolic process (GO:0045939)3.26517316
139regulation of vitamin metabolic process (GO:0030656)3.26066794
140alkaloid metabolic process (GO:0009820)3.24431437
141carboxylic acid catabolic process (GO:0046395)3.23038731
142organic acid catabolic process (GO:0016054)3.23038731
143sulfur compound transport (GO:0072348)3.22896066
144monocarboxylic acid catabolic process (GO:0072329)3.22739475
145lipoprotein metabolic process (GO:0042157)3.21808301
146oligosaccharide catabolic process (GO:0009313)3.21403849
147actin filament depolymerization (GO:0030042)3.18574865
148renal tubule development (GO:0061326)3.17949776
149arginine metabolic process (GO:0006525)3.14748081
150aromatic amino acid family metabolic process (GO:0009072)3.12932394
151regulation of apoptotic process involved in morphogenesis (GO:1902337)3.11953397
152pyrimidine ribonucleoside catabolic process (GO:0046133)3.11298361
153adhesion of symbiont to host (GO:0044406)3.08199866
154succinate metabolic process (GO:0006105)3.07968254
155diacylglycerol metabolic process (GO:0046339)3.05014886
156peptide hormone processing (GO:0016486)3.01079219
157phospholipid efflux (GO:0033700)3.00951756
158ceramide catabolic process (GO:0046514)3.00215279
159cellular response to vitamin D (GO:0071305)2.99419161
160fat-soluble vitamin metabolic process (GO:0006775)2.99073987
161digestive system process (GO:0022600)2.94979744
162positive regulation of icosanoid secretion (GO:0032305)2.94494752
163omega-hydroxylase P450 pathway (GO:0097267)2.93360849
164citrulline biosynthetic process (GO:0019240)2.92749244
165drinking behavior (GO:0042756)2.92570459
166antibacterial humoral response (GO:0019731)2.90612109
167renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.90525554
168plasma lipoprotein particle assembly (GO:0034377)2.87466946
169regulation of protein glycosylation (GO:0060049)2.85621107
170daunorubicin metabolic process (GO:0044597)2.85420520
171polyketide metabolic process (GO:0030638)2.85420520
172doxorubicin metabolic process (GO:0044598)2.85420520
173phenylpropanoid metabolic process (GO:0009698)2.85166340
174sodium ion homeostasis (GO:0055078)2.84634807
175positive regulation of glycoprotein biosynthetic process (GO:0010560)2.84411510
176glutamine family amino acid biosynthetic process (GO:0009084)2.83924230
177regulation of cholesterol esterification (GO:0010872)2.83617154
178transcytosis (GO:0045056)2.82487465
179cGMP-mediated signaling (GO:0019934)2.80432760
180glucose 6-phosphate metabolic process (GO:0051156)2.78680958
181regulation of extracellular matrix disassembly (GO:0010715)2.78285896
182triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.77267420
183positive regulation of triglyceride lipase activity (GO:0061365)2.76420682
184positive regulation of lipoprotein lipase activity (GO:0051006)2.76420682
185antimicrobial humoral response (GO:0019730)2.74964566

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.40204314
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.62170457
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.28934906
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.92513349
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.89204530
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.84015850
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.52718321
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.44504028
9CDX2_20551321_ChIP-Seq_CACO-2_Human3.42565280
10CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.37932491
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.32594169
12RARG_19884340_ChIP-ChIP_MEFs_Mouse3.26978561
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.23175819
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.78585009
15SOX2_27498859_Chip-Seq_STOMACH_Mouse2.74751137
16GATA4_25053715_ChIP-Seq_YYC3_Human2.72113059
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.51213043
18AR_21909140_ChIP-Seq_LNCAP_Human2.33606281
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.30768423
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.29548566
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17499306
22GATA6_25053715_ChIP-Seq_YYC3_Human2.00203837
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.98936108
24SOX2_20726797_ChIP-Seq_SW620_Human1.97342972
25ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.88033657
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.87973369
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.87907664
28CLOCK_20551151_ChIP-Seq_293T_Human1.87394619
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.87275797
30FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.86920809
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.86424751
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74799198
33ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.68936848
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67982302
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.61777903
36ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.61248622
37NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.61054088
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.60700005
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.60365169
40* HNF4A_19822575_ChIP-Seq_HepG2_Human1.53640296
41FOXA2_19822575_ChIP-Seq_HepG2_Human1.53260202
42SALL4_18804426_ChIP-ChIP_XEN_Mouse1.48199110
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45827920
44TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.44556944
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38749633
46* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37950306
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.37034562
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30601294
49RACK7_27058665_Chip-Seq_MCF-7_Human1.29435226
50PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27448167
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25937545
52AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.24143095
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.23116776
54TP53_18474530_ChIP-ChIP_U2OS_Human1.21882564
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20050274
56SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18390420
57GATA1_22025678_ChIP-Seq_K562_Human1.16239252
58SMAD3_21741376_ChIP-Seq_HESCs_Human1.15888654
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14388604
60FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13945667
61GATA2_19941826_ChIP-Seq_K562_Human1.12880400
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10760986
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.10060085
64TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08915312
65AHR_22903824_ChIP-Seq_MCF-7_Human1.08253285
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08175860
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07937062
68GATA3_24758297_ChIP-Seq_MCF-7_Human1.05449724
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04950489
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04370193
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.02828303
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02635164
73FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02366685
74TBX20_22328084_ChIP-Seq_HEART_Mouse1.02171203
75TBX20_22080862_ChIP-Seq_HEART_Mouse1.02171203
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00524966
77NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99893875
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99741776
79ESR1_20079471_ChIP-ChIP_T-47D_Human0.97709372
80P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97430931
81ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96795776
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96121597
83EGR1_19032775_ChIP-ChIP_M12_Human0.94556940
84RUNX1_27514584_Chip-Seq_MCF-7_Human0.94144826
85GATA1_19941826_ChIP-Seq_K562_Human0.93917068
86CDX2_22108803_ChIP-Seq_LS180_Human0.93103703
87RXR_22108803_ChIP-Seq_LS180_Human0.92693331
88ATF3_27146783_Chip-Seq_COLON_Human0.92638906
89LXR_22292898_ChIP-Seq_THP-1_Human0.90150956
90HNFA_21074721_ChIP-Seq_CACO-2_Human0.90029630
91SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89950756
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89817772
93TP53_16413492_ChIP-PET_HCT116_Human0.89782324
94ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89290273
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88810291
96PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88492460
97ARNT_22903824_ChIP-Seq_MCF-7_Human0.87611653
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.87024733
99CEBPB_22108803_ChIP-Seq_LS180_Human0.85734002
100VDR_22108803_ChIP-Seq_LS180_Human0.85313886
101IRF8_21731497_ChIP-ChIP_J774_Mouse0.85250436
102STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.84854198
103VDR_24787735_ChIP-Seq_THP-1_Human0.84417717
104* TP63_23658742_ChIP-Seq_EP156T_Human0.84312672
105KLF5_25053715_ChIP-Seq_YYC3_Human0.83667311
106* CJUN_26792858_Chip-Seq_BT549_Human0.82627951
107FOXA1_21572438_ChIP-Seq_LNCaP_Human0.82327659
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.80981465
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.80981465
110SMAD4_21741376_ChIP-Seq_HESCs_Human0.80853477
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79056228
112BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.78713014
113* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.78406175
114CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.78172643
115CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77570471
116P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.76673211
117PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.76629649
118JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76083255
119NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75698661
120NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75698661
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75575918
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.74802515
123STAT3_1855785_ChIP-Seq_MESCs_Mouse0.74636003
124Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.74329813
125GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.73760998
126FOXA1_25552417_ChIP-Seq_VCAP_Human0.73235184
127ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.72576272
128BCAT_22108803_ChIP-Seq_LS180_Human0.71751001
129TCF4_18268006_ChIP-ChIP_LS174T_Human0.71584608
130DROSHA_22980978_ChIP-Seq_HELA_Human0.71289053
131NFYA_21822215_ChIP-Seq_K562_Human0.71157409
132PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.70600074

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.45758502
2MP0004043_abnormal_pH_regulation5.27614105
3MP0005332_abnormal_amino_acid4.45046104
4MP0002139_abnormal_hepatobiliary_system4.28804569
5MP0004019_abnormal_vitamin_homeostasis4.21725720
6MP0003183_abnormal_peptide_metabolism4.02591673
7MP0009643_abnormal_urine_homeostasis3.71508266
8MP0002138_abnormal_hepatobiliary_system3.60605924
9MP0001958_emphysema3.55154350
10MP0005085_abnormal_gallbladder_physiolo3.29308890
11MP0005083_abnormal_biliary_tract3.25069679
12MP0001765_abnormal_ion_homeostasis3.09199172
13MP0005365_abnormal_bile_salt2.97281361
14MP0003195_calcinosis2.90253359
15MP0001666_abnormal_nutrient_absorption2.90015242
16MP0001756_abnormal_urination2.80513976
17MP0008875_abnormal_xenobiotic_pharmacok2.71980098
18MP0002136_abnormal_kidney_physiology2.68580171
19MP0005636_abnormal_mineral_homeostasis2.66258037
20MP0003252_abnormal_bile_duct2.45316349
21MP0009840_abnormal_foam_cell2.39899896
22MP0005377_hearing/vestibular/ear_phenot2.28680205
23MP0003878_abnormal_ear_physiology2.28680205
24MP0005084_abnormal_gallbladder_morpholo2.12564093
25MP0003941_abnormal_skin_development1.85984235
26MP0003191_abnormal_cellular_cholesterol1.77994635
27MP0005058_abnormal_lysosome_morphology1.70275159
28MP0005220_abnormal_exocrine_pancreas1.66214816
29MP0000538_abnormal_urinary_bladder1.63991015
30MP0004782_abnormal_surfactant_physiolog1.62297240
31MP0003866_abnormal_defecation1.62250240
32MP0003300_gastrointestinal_ulcer1.58442780
33MP0004264_abnormal_extraembryonic_tissu1.48276670
34MP0008961_abnormal_basal_metabolism1.45494090
35MP0003186_abnormal_redox_activity1.45342651
36MP0005670_abnormal_white_adipose1.40780749
37MP0010352_gastrointestinal_tract_polyps1.36673875
38MP0008004_abnormal_stomach_pH1.35164790
39MP0003879_abnormal_hair_cell1.30405681
40MP0002928_abnormal_bile_duct1.23320014
41MP0005584_abnormal_enzyme/coenzyme_acti1.21517208
42MP0002876_abnormal_thyroid_physiology1.18832570
43MP0000477_abnormal_intestine_morphology1.17215192
44MP0003806_abnormal_nucleotide_metabolis1.16369410
45MP0004272_abnormal_basement_membrane1.16306689
46MP0001664_abnormal_digestion1.13808110
47MP0001873_stomach_inflammation1.12062339
48MP0005166_decreased_susceptibility_to1.11270333
49MP0002135_abnormal_kidney_morphology1.10456690
50MP0005408_hypopigmentation1.09584870
51MP0005319_abnormal_enzyme/_coenzyme1.05878597
52MP0003283_abnormal_digestive_organ1.05375959
53MP0010234_abnormal_vibrissa_follicle1.04443891
54MP0000230_abnormal_systemic_arterial1.02459048
55MP0005451_abnormal_body_composition1.01382890
56MP0002118_abnormal_lipid_homeostasis0.98369786
57MP0002168_other_aberrant_phenotype0.98207660
58MP0003959_abnormal_lean_body0.97669485
59MP0006082_CNS_inflammation0.96968971
60MP0004885_abnormal_endolymph0.96517022
61MP0001542_abnormal_bone_strength0.95207361
62MP0009785_altered_susceptibility_to0.93201963
63MP0003705_abnormal_hypodermis_morpholog0.92855357
64MP0001177_atelectasis0.92784455
65MP0002089_abnormal_postnatal_growth/wei0.89166442
66MP0002796_impaired_skin_barrier0.88609403
67MP0001501_abnormal_sleep_pattern0.87582626
68MP0000462_abnormal_digestive_system0.86468859
69MP0003638_abnormal_response/metabolism_0.86343883
70MP0008995_early_reproductive_senescence0.86094119
71MP0001764_abnormal_homeostasis0.85667812
72MP0002098_abnormal_vibrissa_morphology0.84764887
73MP0009697_abnormal_copulation0.83410279
74MP0002896_abnormal_bone_mineralization0.83061233
75MP0003950_abnormal_plasma_membrane0.81936351
76MP0009384_cardiac_valve_regurgitation0.81424933
77MP0006036_abnormal_mitochondrial_physio0.79797675
78MP0010329_abnormal_lipoprotein_level0.79030898
79MP0004883_abnormal_blood_vessel0.77898439
80MP0008872_abnormal_physiological_respon0.77062705
81MP0002971_abnormal_brown_adipose0.75376208
82MP0001663_abnormal_digestive_system0.73648920
83MP0005409_darkened_coat_color0.71448112
84MP0006054_spinal_hemorrhage0.70930744
85MP0001845_abnormal_inflammatory_respons0.70640704
86MP0005388_respiratory_system_phenotype0.70487725
87MP0002133_abnormal_respiratory_system0.70487725
88MP0005310_abnormal_salivary_gland0.70391313
89MP0003718_maternal_effect0.68938924
90MP0000249_abnormal_blood_vessel0.68858883
91MP0000537_abnormal_urethra_morphology0.68787869
92MP0005381_digestive/alimentary_phenotyp0.68322974
93MP0002254_reproductive_system_inflammat0.67910686
94MP0005535_abnormal_body_temperature0.67661352
95MP0002166_altered_tumor_susceptibility0.64841621
96MP0002396_abnormal_hematopoietic_system0.63441727
97MP0009642_abnormal_blood_homeostasis0.63236591
98MP0010678_abnormal_skin_adnexa0.63043175
99MP0010386_abnormal_urinary_bladder0.62514666
100MP0005595_abnormal_vascular_smooth0.60755177
101MP0005501_abnormal_skin_physiology0.60666750
102MP0003724_increased_susceptibility_to0.58719892
103MP0005395_other_phenotype0.57941817
104MP0000609_abnormal_liver_physiology0.57816274
105MP0005448_abnormal_energy_balance0.57048369
106MP0003115_abnormal_respiratory_system0.56806398
107MP0009780_abnormal_chondrocyte_physiolo0.56082783
108MP0003123_paternal_imprinting0.54552942
109MP0005376_homeostasis/metabolism_phenot0.53800416
110MP0005666_abnormal_adipose_tissue0.53409067
111MP0004233_abnormal_muscle_weight0.53121986
112MP0005165_increased_susceptibility_to0.52583765
113MP0000678_abnormal_parathyroid_gland0.52296489
114MP0009115_abnormal_fat_cell0.51553696
115MP0000490_abnormal_crypts_of0.51171626
116MP0002998_abnormal_bone_remodeling0.50886443
117MP0004147_increased_porphyrin_level0.50520092
118MP0004484_altered_response_of0.50083897
119MP0010155_abnormal_intestine_physiology0.49628113
120MP0000465_gastrointestinal_hemorrhage0.49212383
121MP0003303_peritoneal_inflammation0.48642115
122MP0001790_abnormal_immune_system0.46616907
123MP0005387_immune_system_phenotype0.46616907
124MP0002078_abnormal_glucose_homeostasis0.45481381
125MP0009764_decreased_sensitivity_to0.45416697
126MP0006138_congestive_heart_failure0.44676094
127MP0004215_abnormal_myocardial_fiber0.43751824
128MP0004858_abnormal_nervous_system0.42773624
129MP0008775_abnormal_heart_ventricle0.42633806
130MP0009379_abnormal_foot_pigmentation0.42500239
131MP0003868_abnormal_feces_composition0.42435001
132MP0003045_fibrosis0.41986400
133MP0000598_abnormal_liver_morphology0.40903979
134MP0002009_preneoplasia0.40626903
135MP0003795_abnormal_bone_structure0.39353149
136MP0003953_abnormal_hormone_level0.39340399
137MP0008469_abnormal_protein_level0.39193448
138MP0005025_abnormal_response_to0.38262962
139MP0002006_tumorigenesis0.37509479

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)7.96188967
2Hyperactive renin-angiotensin system (HP:0000841)7.03736622
3Increased circulating renin level (HP:0000848)6.82978969
4Hypokalemic alkalosis (HP:0001949)6.70831267
5Metabolic alkalosis (HP:0200114)6.60579546
6Abnormality of chloride homeostasis (HP:0011422)6.56133206
7Hypomagnesemia (HP:0002917)6.18385896
8Abnormality of renal excretion (HP:0011036)5.72788575
9Polyuria (HP:0000103)5.71795748
10Increased purine levels (HP:0004368)5.52926765
11Hyperuricemia (HP:0002149)5.52926765
12Abnormal urine output (HP:0012590)5.43957681
13Renal salt wasting (HP:0000127)5.40240627
14Abnormality of magnesium homeostasis (HP:0004921)5.27467757
15Proximal tubulopathy (HP:0000114)5.06857285
16Hypobetalipoproteinemia (HP:0003563)4.85528411
17Abnormality of purine metabolism (HP:0004352)4.71389539
18Abnormality of renin-angiotensin system (HP:0000847)4.59407900
19Abnormal drinking behavior (HP:0030082)4.55291380
20Polydipsia (HP:0001959)4.55291380
21Hyperglycinuria (HP:0003108)4.51342068
22Hyperaldosteronism (HP:0000859)4.47812497
23Alkalosis (HP:0001948)4.45278700
24Abnormality of glutamine family amino acid metabolism (HP:0010902)4.39804278
25Tetany (HP:0001281)4.36877058
26Abnormality of monocarboxylic acid metabolism (HP:0010996)4.15457515
27Fat malabsorption (HP:0002630)3.98730315
28Glycosuria (HP:0003076)3.87028663
29Abnormality of urine glucose concentration (HP:0011016)3.87028663
30Thin bony cortex (HP:0002753)3.75520069
31Abnormality of serine family amino acid metabolism (HP:0010894)3.74249888
32Abnormality of glycine metabolism (HP:0010895)3.74249888
33Hypercalciuria (HP:0002150)3.72433427
34Generalized aminoaciduria (HP:0002909)3.66295372
35Conjugated hyperbilirubinemia (HP:0002908)3.65433296
36Tubulointerstitial fibrosis (HP:0005576)3.64778213
37Abnormality of the vitamin B12 metabolism (HP:0004341)3.55424603
38Chronic diarrhea (HP:0002028)3.55028379
39Ketoacidosis (HP:0001993)3.49584799
40Abnormality of nucleobase metabolism (HP:0010932)3.46048305
41Hypokalemia (HP:0002900)3.41722207
42Acanthocytosis (HP:0001927)3.36998442
43Abnormality of vitamin B metabolism (HP:0004340)3.27199395
44Intrahepatic cholestasis (HP:0001406)3.18875057
45Renal tubular acidosis (HP:0001947)3.13466189
46Pigmentary retinal degeneration (HP:0001146)3.12791452
47Hyperphosphaturia (HP:0003109)3.11644697
48Ketosis (HP:0001946)3.00935740
49Abnormality of potassium homeostasis (HP:0011042)2.97861638
50Flat acetabular roof (HP:0003180)2.95826838
51Abnormal urine phosphate concentration (HP:0012599)2.91341102
52Delayed epiphyseal ossification (HP:0002663)2.90668650
53Abnormality of vitamin metabolism (HP:0100508)2.90324588
54Focal segmental glomerulosclerosis (HP:0000097)2.88594596
55Tubular atrophy (HP:0000092)2.84793460
56Systemic lupus erythematosus (HP:0002725)2.83830169
57Abdominal distention (HP:0003270)2.80666966
58Complement deficiency (HP:0004431)2.75881923
59Abnormality of proline metabolism (HP:0010907)2.74562855
60Hydroxyprolinuria (HP:0003080)2.74562855
61Abnormality of fatty-acid metabolism (HP:0004359)2.74392383
62Hemorrhage of the eye (HP:0011885)2.74289588
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.74230862
64Dehydration (HP:0001944)2.73005792
65Malnutrition (HP:0004395)2.70690064
66Glomerulonephritis (HP:0000099)2.62475389
67Hyperammonemia (HP:0001987)2.52245916
68Nephrolithiasis (HP:0000787)2.51686523
69Hyperglycinemia (HP:0002154)2.50988533
70Xanthomatosis (HP:0000991)2.50760046
71Neonatal onset (HP:0003623)2.48233192
72Widely patent fontanelles and sutures (HP:0004492)2.47423923
73Nephrocalcinosis (HP:0000121)2.45485032
74Vascular calcification (HP:0004934)2.44886700
75Abnormality of complement system (HP:0005339)2.44511413
76Hypophosphatemia (HP:0002148)2.43017553
77Right ventricular cardiomyopathy (HP:0011663)2.41207294
78Delayed CNS myelination (HP:0002188)2.39883785
79Tubulointerstitial abnormality (HP:0001969)2.39799946
80Hypolipoproteinemia (HP:0010981)2.39062078
81Late onset (HP:0003584)2.38380815
82Rickets (HP:0002748)2.37673410
83Hyponatremia (HP:0002902)2.35643272
84Metabolic acidosis (HP:0001942)2.34555777
85Tachypnea (HP:0002789)2.34375915
86Steatorrhea (HP:0002570)2.32459059
87Ileus (HP:0002595)2.32113936
88Enlarged kidneys (HP:0000105)2.31359420
89Abnormality of sodium homeostasis (HP:0010931)2.26269488
90Vacuolated lymphocytes (HP:0001922)2.24663349
91Glomerulosclerosis (HP:0000096)2.24008081
92Dicarboxylic aciduria (HP:0003215)2.23848537
93Abnormality of dicarboxylic acid metabolism (HP:0010995)2.23848537
94Hypotension (HP:0002615)2.21862744
95Abnormality of renal resorption (HP:0011038)2.19772753
96Cardiovascular calcification (HP:0011915)2.17553102
97Bicornuate uterus (HP:0000813)2.15642044
98Renal tubular dysfunction (HP:0000124)2.11728973
99Abnormality of sulfur amino acid metabolism (HP:0004339)2.09643023
100Vomiting (HP:0002013)2.07088240
101Adrenal overactivity (HP:0002717)2.06346261
102Abnormality of the renal cortex (HP:0011035)2.05896688
103Abnormal glucose tolerance (HP:0001952)2.05860087
104Abnormality of the costochondral junction (HP:0000919)2.04235286
105Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.04071456
106Metaphyseal cupping (HP:0003021)2.04043518
107Wide cranial sutures (HP:0010537)2.02340656
108Nephritis (HP:0000123)2.01718260
109Potter facies (HP:0002009)2.00284937
110Facial shape deformation (HP:0011334)2.00284937
111Abnormality of aromatic amino acid family metabolism (HP:0004338)1.98385769
112Abnormal enzyme/coenzyme activity (HP:0012379)1.93559368
113Elevated alkaline phosphatase (HP:0003155)1.93031961
114Bilateral sensorineural hearing impairment (HP:0008619)1.92250632
115Tubulointerstitial nephritis (HP:0001970)1.91272306
116Enlarged epiphyses (HP:0010580)1.90730894
117Confusion (HP:0001289)1.90041413
118Megaloblastic anemia (HP:0001889)1.88826084
119Lethargy (HP:0001254)1.88231760
120Hyperkalemia (HP:0002153)1.87575494
121Decreased circulating renin level (HP:0003351)1.87512277
122Osteomalacia (HP:0002749)1.87335379
123Abnormal tarsal ossification (HP:0008369)1.86513443
124Abnormality of alkaline phosphatase activity (HP:0004379)1.86172428
125Chondrocalcinosis (HP:0000934)1.85235764
126Hypophosphatemic rickets (HP:0004912)1.82704876
127Congenital sensorineural hearing impairment (HP:0008527)1.82344850
128Irritability (HP:0000737)1.82236824
129Nausea (HP:0002018)1.81042190
130Interstitial pulmonary disease (HP:0006530)1.78860838
131Abnormal pancreas size (HP:0012094)1.77077105
132Abnormality of Sharpey fibers (HP:0100685)1.75311927
133Methylmalonic aciduria (HP:0012120)1.72652206
134Metaphyseal irregularity (HP:0003025)1.69776462
135Abnormality of serum amino acid levels (HP:0003112)1.69027092

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK47.75860287
2ACVR1B6.60247592
3WNK36.40886628
4OXSR16.23785883
5STK393.97671991
6BCKDK3.49287707
7PIK3CA2.79955745
8MAP3K32.64856649
9LMTK22.60493870
10MAP3K102.29258187
11MST42.28525052
12TNIK2.05641125
13TAOK22.02025771
14STK38L1.96072373
15NUAK11.90140972
16MAP3K111.89475153
17BLK1.85720582
18TAOK11.81115377
19MST1R1.78572291
20PDK31.77219581
21PDK41.77219581
22WNK11.64447911
23SGK4941.61533606
24SGK2231.61533606
25FRK1.57661043
26PDK21.51443506
27MAP2K31.49696038
28TGFBR21.35303521
29CASK1.24542451
30PRPF4B1.24404051
31EPHA31.21924592
32LRRK21.19986366
33EPHA41.10742364
34SGK21.03936906
35DDR21.01815332
36NEK11.01739694
37PAK41.00783405
38STK100.98134448
39SGK30.92069083
40EPHB10.87614600
41PTK60.86724688
42MATK0.78516569
43TESK10.77350731
44GSK3A0.76186328
45MAP2K60.74358343
46ERN10.73614770
47STK380.72408384
48MYLK0.71874791
49FGFR30.70632173
50ZAP700.68660338
51PTK20.67951573
52EPHA20.66664132
53TRIB30.66623907
54MAP2K20.66254635
55AKT30.66144144
56EPHB20.64593793
57BMPR20.64454855
58DAPK20.63320206
59FGFR40.60487970
60RIPK40.59202113
61FER0.59124713
62MAP3K20.56341306
63PRKG20.56140861
64FGFR20.56120657
65NME10.55801774
66MAP3K140.54409930
67PIM10.53265503
68DYRK1B0.52088058
69IRAK30.51961647
70MAP3K70.51657773
71DAPK30.51634334
72TBK10.50886539
73SYK0.49808683
74TYK20.49554625
75MAP4K10.48576736
76SRC0.46587004
77PRKAA20.46392096
78MAP3K120.46349338
79PRKCI0.45818955
80CSF1R0.43348246
81MET0.42634633
82ILK0.42538727
83GRK60.41920574
84PBK0.41731474
85NEK90.41383202
86GRK50.41310413
87BMX0.41302098
88PRKAA10.38676670
89MAPK110.37469234
90JAK10.37224126
91TIE10.37114345
92ERBB20.36909606
93RIPK10.36689946
94SGK10.36562203
95CDC42BPA0.33956288
96IRAK10.33892614
97CAMK2D0.33738295
98PINK10.32960156
99TEC0.32899601
100PDGFRB0.31173055
101ITK0.30798217
102PKN20.30165849
103PRKCQ0.29140220
104NTRK30.29024580
105EIF2AK30.28394353
106ROCK10.28331841
107MAP3K10.28298103
108MAPK70.28087350
109LYN0.27806089
110PIK3CG0.27480159
111MELK0.26879161
112MAP2K10.26738790
113PRKCZ0.26479845
114MAPKAPK20.26036942
115BCR0.25283175
116FGR0.24036308
117LATS10.23979297
118TRPM70.23659735
119SMG10.23610139
120STK240.23407710
121GRK70.22830085
122MAP3K80.22603134
123PRKACG0.22403600
124PRKCD0.22158729
125FYN0.22100225
126TGFBR10.20864712
127NLK0.20857116
128ERBB40.19401800
129INSRR0.18650283
130MAPK150.18343839
131PDPK10.18120710
132LIMK10.16668512
133PRKCA0.15877125
134EGFR0.14256398
135PAK30.14154686
136GRK10.13106316
137TAOK30.12938962
138ABL20.11013553
139NME20.10773087
140IGF1R0.10677511
141MAP3K50.09276457
142PRKACA0.08749135
143PTK2B0.08138176
144PDK10.08082256

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.71936463
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.59162548
3Butanoate metabolism_Homo sapiens_hsa006503.45887331
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.34053176
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.15192118
6Propanoate metabolism_Homo sapiens_hsa006403.14665640
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.07359146
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.91359749
9Caffeine metabolism_Homo sapiens_hsa002322.77769150
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.73434453
11Vitamin digestion and absorption_Homo sapiens_hsa049772.42862919
12Fatty acid degradation_Homo sapiens_hsa000712.36873622
13Peroxisome_Homo sapiens_hsa041462.33822674
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.29957579
15Tryptophan metabolism_Homo sapiens_hsa003802.23955552
16Pyruvate metabolism_Homo sapiens_hsa006202.21762158
17Protein digestion and absorption_Homo sapiens_hsa049742.21598642
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.19864766
19Sulfur metabolism_Homo sapiens_hsa009202.17443127
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.93975457
21beta-Alanine metabolism_Homo sapiens_hsa004101.85755314
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73946559
23Mineral absorption_Homo sapiens_hsa049781.71631328
24Glutathione metabolism_Homo sapiens_hsa004801.66548142
25Bile secretion_Homo sapiens_hsa049761.64698767
26Collecting duct acid secretion_Homo sapiens_hsa049661.59352164
27Fatty acid metabolism_Homo sapiens_hsa012121.59080430
28Carbon metabolism_Homo sapiens_hsa012001.55071714
29Arginine and proline metabolism_Homo sapiens_hsa003301.51073497
30Linoleic acid metabolism_Homo sapiens_hsa005911.40839513
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.38087860
32Starch and sucrose metabolism_Homo sapiens_hsa005001.35639159
33Renin-angiotensin system_Homo sapiens_hsa046141.29916683
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.28171173
35Histidine metabolism_Homo sapiens_hsa003401.25131620
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21333137
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21307701
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.20697652
39Lysine degradation_Homo sapiens_hsa003101.18443949
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18092716
41Other glycan degradation_Homo sapiens_hsa005111.17486160
42Folate biosynthesis_Homo sapiens_hsa007901.15168038
43PPAR signaling pathway_Homo sapiens_hsa033201.13672914
44Glycerolipid metabolism_Homo sapiens_hsa005611.13423186
45Selenocompound metabolism_Homo sapiens_hsa004501.10384262
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06373695
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04928155
48Nitrogen metabolism_Homo sapiens_hsa009101.03259491
49Pancreatic secretion_Homo sapiens_hsa049721.01622701
50Primary bile acid biosynthesis_Homo sapiens_hsa001201.01138299
51Arginine biosynthesis_Homo sapiens_hsa002200.98131179
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94855292
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.89188176
54Fat digestion and absorption_Homo sapiens_hsa049750.88452431
55Fructose and mannose metabolism_Homo sapiens_hsa000510.86672841
56Biosynthesis of amino acids_Homo sapiens_hsa012300.86556010
57Complement and coagulation cascades_Homo sapiens_hsa046100.83321624
58Oxidative phosphorylation_Homo sapiens_hsa001900.82275617
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78928078
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68484473
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67931546
62Phenylalanine metabolism_Homo sapiens_hsa003600.65538250
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65098768
64Staphylococcus aureus infection_Homo sapiens_hsa051500.64561194
65Fatty acid elongation_Homo sapiens_hsa000620.63923674
66Chemical carcinogenesis_Homo sapiens_hsa052040.61501877
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.59585476
68Ether lipid metabolism_Homo sapiens_hsa005650.59020557
69Thyroid hormone synthesis_Homo sapiens_hsa049180.58650356
70Vibrio cholerae infection_Homo sapiens_hsa051100.58626063
71Lysosome_Homo sapiens_hsa041420.57637522
72Metabolic pathways_Homo sapiens_hsa011000.55223181
73Pentose phosphate pathway_Homo sapiens_hsa000300.55079101
74Parkinsons disease_Homo sapiens_hsa050120.51167035
75Asthma_Homo sapiens_hsa053100.48539408
76Steroid biosynthesis_Homo sapiens_hsa001000.48317505
77Retinol metabolism_Homo sapiens_hsa008300.46770644
78Gastric acid secretion_Homo sapiens_hsa049710.46576712
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.45080018
80Arachidonic acid metabolism_Homo sapiens_hsa005900.44814379
81Tight junction_Homo sapiens_hsa045300.42182713
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.41880038
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.41600121
84ABC transporters_Homo sapiens_hsa020100.39262802
85Allograft rejection_Homo sapiens_hsa053300.38671499
86Bladder cancer_Homo sapiens_hsa052190.34160600
87Insulin resistance_Homo sapiens_hsa049310.33776583
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33703192
89Graft-versus-host disease_Homo sapiens_hsa053320.33529074
90Renin secretion_Homo sapiens_hsa049240.33408075
91Autoimmune thyroid disease_Homo sapiens_hsa053200.32851097
92Systemic lupus erythematosus_Homo sapiens_hsa053220.30799053
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.28779280
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.25746046
95Hepatitis C_Homo sapiens_hsa051600.24807380
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24502699
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23589569
98Galactose metabolism_Homo sapiens_hsa000520.22338926
99Alzheimers disease_Homo sapiens_hsa050100.20995424
100Fatty acid biosynthesis_Homo sapiens_hsa000610.20342734
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20188965
102Adherens junction_Homo sapiens_hsa045200.19771463
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18817093
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17131956
105African trypanosomiasis_Homo sapiens_hsa051430.16725172
106ECM-receptor interaction_Homo sapiens_hsa045120.16628363
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.16378273
108Sphingolipid metabolism_Homo sapiens_hsa006000.15969902
109Sulfur relay system_Homo sapiens_hsa041220.14632090
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14053240
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12549215
112Huntingtons disease_Homo sapiens_hsa050160.11906906
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.11680564
114Tyrosine metabolism_Homo sapiens_hsa003500.11527119
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.09513837
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.08814995
117Type I diabetes mellitus_Homo sapiens_hsa049400.08535490
118Choline metabolism in cancer_Homo sapiens_hsa052310.04870559
119Glucagon signaling pathway_Homo sapiens_hsa049220.04737946
120Inositol phosphate metabolism_Homo sapiens_hsa005620.02531885
121Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.02487435
122Phototransduction_Homo sapiens_hsa047440.01901607
123One carbon pool by folate_Homo sapiens_hsa006700.01312860

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