TINAGL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar in sequence to tubulointerstitial nephritis antigen, a secreted glycoprotein that is recognized by antibodies in some types of immune-related tubulointerstitial nephritis. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1basement membrane organization (GO:0071711)5.13908527
2retina vasculature morphogenesis in camera-type eye (GO:0061299)4.99091347
3cell adhesion mediated by integrin (GO:0033627)4.87112784
4negative regulation of keratinocyte proliferation (GO:0010839)4.70352878
5hemidesmosome assembly (GO:0031581)4.53231729
6polarized epithelial cell differentiation (GO:0030859)4.52968982
7renal filtration (GO:0097205)4.42398044
8keratinocyte proliferation (GO:0043616)4.37175532
9regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.34112666
10atrioventricular valve morphogenesis (GO:0003181)4.29740135
11regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.28349237
12epithelial cell-cell adhesion (GO:0090136)4.22724321
13mesodermal cell differentiation (GO:0048333)4.15612634
14endocardial cushion development (GO:0003197)4.08067710
15vascular endothelial growth factor signaling pathway (GO:0038084)4.06428504
16negative regulation of chondrocyte differentiation (GO:0032331)4.06180224
17branching involved in salivary gland morphogenesis (GO:0060445)3.95379419
18establishment of apical/basal cell polarity (GO:0035089)3.92306918
19cell-substrate junction assembly (GO:0007044)3.91517419
20regulation of cardioblast differentiation (GO:0051890)3.89981714
21wound healing, spreading of epidermal cells (GO:0035313)3.88898040
22endodermal cell differentiation (GO:0035987)3.88046345
23regulation of hippo signaling (GO:0035330)3.78656927
24positive regulation of endothelial cell apoptotic process (GO:2000353)3.65038440
25bundle of His cell to Purkinje myocyte communication (GO:0086069)3.52786943
26skin morphogenesis (GO:0043589)3.52538085
27regulation of water loss via skin (GO:0033561)3.51330537
28glomerular basement membrane development (GO:0032836)3.48516181
29chondrocyte proliferation (GO:0035988)3.44752196
30negative regulation of cartilage development (GO:0061037)3.44165515
31regulation of tight junction assembly (GO:2000810)3.43727308
32substrate adhesion-dependent cell spreading (GO:0034446)3.42926612
33endothelial cell morphogenesis (GO:0001886)3.39892250
34stress fiber assembly (GO:0043149)3.39247041
35plasma membrane repair (GO:0001778)3.37033229
36low-density lipoprotein particle clearance (GO:0034383)3.36928230
37peptidyl-proline hydroxylation (GO:0019511)3.35148289
38regulation of keratinocyte proliferation (GO:0010837)3.35017946
39establishment of skin barrier (GO:0061436)3.32946752
40protein localization to endosome (GO:0036010)3.30131079
41blood vessel endothelial cell migration (GO:0043534)3.28417115
42apoptotic cell clearance (GO:0043277)3.27532450
43adherens junction assembly (GO:0034333)3.26737833
44semaphorin-plexin signaling pathway (GO:0071526)3.25617628
45wound healing, spreading of cells (GO:0044319)3.24945993
46hippo signaling (GO:0035329)3.21198233
47cell migration involved in sprouting angiogenesis (GO:0002042)3.21122155
48cytoskeletal anchoring at plasma membrane (GO:0007016)3.17984087
49establishment or maintenance of monopolar cell polarity (GO:0061339)3.16881292
50establishment of monopolar cell polarity (GO:0061162)3.16881292
514-hydroxyproline metabolic process (GO:0019471)3.14272808
52embryonic foregut morphogenesis (GO:0048617)3.13049287
53negative regulation of fatty acid transport (GO:2000192)3.06945229
54lymphangiogenesis (GO:0001946)3.04755825
55activation of Rac GTPase activity (GO:0032863)2.99900241
56regulation of G0 to G1 transition (GO:0070316)2.99736738
57cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.98390090
58branching involved in mammary gland duct morphogenesis (GO:0060444)2.95079156
59L-serine transport (GO:0015825)2.94822070
60regulation of metalloenzyme activity (GO:0048552)2.94747201
61chemical homeostasis within a tissue (GO:0048875)2.93166672
62protein localization to cell surface (GO:0034394)2.90856737
63regulation of transforming growth factor beta2 production (GO:0032909)2.90657532
64focal adhesion assembly (GO:0048041)2.87443167
65cell-substrate adherens junction assembly (GO:0007045)2.87443167
66glomerular filtration (GO:0003094)2.87355326
67surfactant homeostasis (GO:0043129)2.87105419
68sarcomere organization (GO:0045214)2.85819923
69regulation of integrin-mediated signaling pathway (GO:2001044)2.85226425
70hypotonic response (GO:0006971)2.83829008
71collagen fibril organization (GO:0030199)2.83660754
72protein hydroxylation (GO:0018126)2.82770469
73endothelium development (GO:0003158)2.82507921
74regulation of transforming growth factor beta1 production (GO:0032908)2.82420289
75protein heterotrimerization (GO:0070208)2.82114443
76dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.80186565
77multicellular organismal water homeostasis (GO:0050891)2.76577164
78ventricular cardiac muscle cell action potential (GO:0086005)2.74919642
79regulation of apoptotic process involved in morphogenesis (GO:1902337)2.73618151
80tight junction assembly (GO:0070830)2.72878855
81axon extension involved in axon guidance (GO:0048846)2.72469138
82neuron projection extension involved in neuron projection guidance (GO:1902284)2.72469138
83vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.71933893
84negative regulation of fibrinolysis (GO:0051918)2.70329791
85regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.69905382
86cellular response to vitamin (GO:0071295)2.68366594
87positive regulation of blood vessel endothelial cell migration (GO:0043536)2.66973360
88cell junction assembly (GO:0034329)2.66866455
89regulation of hair follicle development (GO:0051797)2.66496883
90positive regulation of epidermal cell differentiation (GO:0045606)2.64965472
91fibroblast migration (GO:0010761)2.64330656
92regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.63615901
93metanephric nephron epithelium development (GO:0072243)2.62366741
94desmosome organization (GO:0002934)2.62339492
95endothelial cell chemotaxis (GO:0035767)2.62322328
96extracellular matrix disassembly (GO:0022617)2.61207303
97adherens junction organization (GO:0034332)2.60840056
98positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.60729812
99positive regulation of p38MAPK cascade (GO:1900745)2.58658624
100negative regulation of catenin import into nucleus (GO:0035414)2.57244737
101gap junction assembly (GO:0016264)2.57038830
102negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.56113541
103lung vasculature development (GO:0060426)2.56044891
104positive regulation of collagen biosynthetic process (GO:0032967)2.56026693
105positive regulation of epidermis development (GO:0045684)2.55848923
106cell-cell junction assembly (GO:0007043)2.55761457
107apoptotic process involved in morphogenesis (GO:0060561)2.55633763
108positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.55304305
109regulation of transforming growth factor beta production (GO:0071634)2.54626933
110regulation of plasminogen activation (GO:0010755)2.54554567
111negative regulation of cell fate specification (GO:0009996)2.54213023
112cellular response to vitamin D (GO:0071305)2.53423882
113regulation of collagen metabolic process (GO:0010712)2.52805810
114endothelial cell proliferation (GO:0001935)2.52220798
115positive regulation of osteoblast proliferation (GO:0033690)2.52035102
116renal system development (GO:0072001)2.51976721
117cell-substrate adhesion (GO:0031589)2.50732790
118barbed-end actin filament capping (GO:0051016)2.50187406
119positive regulation of pseudopodium assembly (GO:0031274)2.48640676
120positive regulation of collagen metabolic process (GO:0010714)2.48571870
121cell junction organization (GO:0034330)2.46993951
122establishment of epithelial cell polarity (GO:0090162)2.46755310
123negative regulation of anoikis (GO:2000811)2.46114422
124substrate-dependent cell migration (GO:0006929)2.45727102
125establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.45638737
126skin development (GO:0043588)2.44875031
127positive regulation of odontogenesis (GO:0042482)2.44414203
128metanephric nephron tubule development (GO:0072234)2.43969555
129metanephric tubule development (GO:0072170)2.43969555
130positive regulation of epithelial cell migration (GO:0010634)2.43179827
131epidermis development (GO:0008544)2.42928263
132serine transport (GO:0032329)2.42928155
133regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.42341086
134maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.41857280
135glomerular visceral epithelial cell development (GO:0072015)2.41006432
136regulation of collagen biosynthetic process (GO:0032965)2.40407254
137membrane raft organization (GO:0031579)2.40258493
138establishment of endothelial barrier (GO:0061028)2.40130328
139positive regulation of protein localization to plasma membrane (GO:1903078)2.38481927
140cell communication involved in cardiac conduction (GO:0086065)2.38468196
141Golgi transport vesicle coating (GO:0048200)2.38354227
142COPI coating of Golgi vesicle (GO:0048205)2.38354227
143regulation of phospholipase A2 activity (GO:0032429)2.37144317
144cell volume homeostasis (GO:0006884)2.36664958
145citrulline biosynthetic process (GO:0019240)2.35463695
146regulation of gonadotropin secretion (GO:0032276)2.34436517
147positive regulation of receptor recycling (GO:0001921)2.34049080
148regulation of integrin activation (GO:0033623)2.33682343
149muscle cell migration (GO:0014812)2.32363699
150angiogenesis involved in wound healing (GO:0060055)2.32325816
151intermediate filament organization (GO:0045109)2.29892360
152bone remodeling (GO:0046849)2.29786620
153regulation of anoikis (GO:2000209)2.29386325

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.08620084
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.91850885
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.66372191
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.91359467
5CLOCK_20551151_ChIP-Seq_293T_Human3.45876484
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.34915440
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.81512290
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.77969327
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.68770554
10ZNF263_19887448_ChIP-Seq_K562_Human2.59845498
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.49167577
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.49123804
13* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.30947370
14SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.24454451
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.24072721
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.22438635
17* ELK3_25401928_ChIP-Seq_HUVEC_Human2.11877470
18* PPAR_26484153_Chip-Seq_NCI-H1993_Human2.10490075
19SALL4_18804426_ChIP-ChIP_XEN_Mouse2.10410376
20RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.09777905
21PPARA_22158963_ChIP-Seq_LIVER_Mouse2.06902163
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02968107
23RXR_22158963_ChIP-Seq_LIVER_Mouse2.02663302
24GATA2_21666600_ChIP-Seq_HMVEC_Human2.00313387
25* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.90775596
26* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.90775596
27* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.89718125
28RACK7_27058665_Chip-Seq_MCF-7_Human1.83337737
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.80286679
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.78341592
31NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.75709793
32* ATF3_27146783_Chip-Seq_COLON_Human1.75562878
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.74262549
34SOX2_20726797_ChIP-Seq_SW620_Human1.65522862
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.64250709
36* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.64247156
37* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.64220079
38CJUN_26792858_Chip-Seq_BT549_Human1.63266022
39CDX2_20551321_ChIP-Seq_CACO-2_Human1.57220023
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.51179946
41* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.50015691
42SOX2_27498859_Chip-Seq_STOMACH_Mouse1.48572126
43* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46754034
44* GATA4_25053715_ChIP-Seq_YYC3_Human1.44333975
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.43041675
46TBX20_22080862_ChIP-Seq_HEART_Mouse1.40165571
47TBX20_22328084_ChIP-Seq_HEART_Mouse1.40165571
48TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.39050428
49* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38565643
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37015823
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34119675
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32554138
53P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32387767
54NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32378903
55UBF1/2_26484160_Chip-Seq_HMECs_Human1.32108026
56EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.30874161
57* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30681131
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27932133
59* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.27000972
60* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25948844
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25879713
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25829827
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24165385
64* TP63_22573176_ChIP-Seq_HFKS_Human1.24005379
65* LXR_22292898_ChIP-Seq_THP-1_Human1.23258031
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21016802
67AR_21909140_ChIP-Seq_LNCAP_Human1.20857087
68* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19605153
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19042175
70BRD4_25478319_ChIP-Seq_HGPS_Human1.19004528
71SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18325501
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17906572
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16389611
74RUNX1_27514584_Chip-Seq_MCF-7_Human1.15882866
75* GATA6_25053715_ChIP-Seq_YYC3_Human1.15737483
76* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15376932
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14700732
78ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12619605
79TP53_22127205_ChIP-Seq_IMR90_Human1.12401635
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11448412
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10635331
82FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09968755
83KDM2B_26808549_Chip-Seq_K562_Human1.09289117
84GATA1_19941826_ChIP-Seq_K562_Human1.08982462
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08550714
86WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08447381
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08067850
88FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07181284
89JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05086640
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04839675
91KLF5_25053715_ChIP-Seq_YYC3_Human1.01388009
92* TP63_23658742_ChIP-Seq_EP156T_Human1.01329883
93NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01145830
94TCF3_18692474_ChIP-Seq_MEFs_Mouse1.00842353
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00055784
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99897040
97SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99828160
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98700721
99EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98423014
100* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97807863
101FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96256076
102TP53_23651856_ChIP-Seq_MEFs_Mouse0.96012862
103AHR_22903824_ChIP-Seq_MCF-7_Human0.95601702
104TCF4_18268006_ChIP-ChIP_LS174T_Human0.95069397
105* GATA3_24758297_ChIP-Seq_MCF-7_Human0.95064863
106CTCF_27219007_Chip-Seq_Bcells_Human0.93362844
107* TET1_21490601_ChIP-Seq_MESCs_Mouse0.92812436
108ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92071503
109MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.91799903
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90848680
111CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87196458
112NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86735965
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86633114
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85443293
115NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85443293
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84414889
117* ERG_21242973_ChIP-ChIP_JURKAT_Human0.84119256
118SMC4_20622854_ChIP-Seq_HELA_Human0.84038227
119CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82455614
120BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.79073705
121SMAD_19615063_ChIP-ChIP_OVARY_Human0.77514085

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane4.67148248
2MP0000579_abnormal_nail_morphology4.42192599
3MP0005623_abnormal_meninges_morphology3.53094816
4MP0003705_abnormal_hypodermis_morpholog3.40140343
5MP0008438_abnormal_cutaneous_collagen3.16960213
6MP0003566_abnormal_cell_adhesion3.06400393
7MP0006054_spinal_hemorrhage2.82154748
8MP0000762_abnormal_tongue_morphology2.71520715
9MP0000467_abnormal_esophagus_morphology2.69715639
10MP0000566_synostosis2.69370925
11MP0010368_abnormal_lymphatic_system2.64895392
12MP0009384_cardiac_valve_regurgitation2.39079984
13MP0010352_gastrointestinal_tract_polyps2.33683251
14MP0003279_aneurysm2.28018312
15MP0001958_emphysema2.22773546
16MP0005409_darkened_coat_color2.20798415
17MP0005275_abnormal_skin_tensile2.05855952
18MP0004084_abnormal_cardiac_muscle2.05565813
19MP0002098_abnormal_vibrissa_morphology2.00945769
20MP0005023_abnormal_wound_healing1.99821814
21MP0001216_abnormal_epidermal_layer1.96284253
22MP0003091_abnormal_cell_migration1.94318570
23MP0000537_abnormal_urethra_morphology1.89098973
24MP0010678_abnormal_skin_adnexa1.87772610
25MP0000678_abnormal_parathyroid_gland1.75916763
26MP0000013_abnormal_adipose_tissue1.75344697
27MP0010234_abnormal_vibrissa_follicle1.74424806
28MP0001879_abnormal_lymphatic_vessel1.72814476
29MP0003941_abnormal_skin_development1.69721532
30MP0006138_congestive_heart_failure1.55373446
31MP0003300_gastrointestinal_ulcer1.50079556
32MP0002234_abnormal_pharynx_morphology1.42971123
33MP0003828_pulmonary_edema1.42404480
34MP0000767_abnormal_smooth_muscle1.41808981
35MP0002877_abnormal_melanocyte_morpholog1.39883745
36MP0000383_abnormal_hair_follicle1.37892382
37MP0005670_abnormal_white_adipose1.36351834
38MP0010771_integument_phenotype1.36216769
39MP0005167_abnormal_blood-brain_barrier1.34318828
40MP0009780_abnormal_chondrocyte_physiolo1.32951686
41MP0008775_abnormal_heart_ventricle1.32699896
42MP0005164_abnormal_response_to1.31224424
43MP0005084_abnormal_gallbladder_morpholo1.29213628
44MP0002295_abnormal_pulmonary_circulatio1.28613811
45MP0005257_abnormal_intraocular_pressure1.27004772
46MP0009053_abnormal_anal_canal1.22167775
47MP0002138_abnormal_hepatobiliary_system1.21633193
48MP0002060_abnormal_skin_morphology1.21017152
49MP0000534_abnormal_ureter_morphology1.20938327
50MP0010030_abnormal_orbit_morphology1.20137708
51MP0004185_abnormal_adipocyte_glucose1.18988396
52MP0000377_abnormal_hair_follicle1.18875450
53MP0002139_abnormal_hepatobiliary_system1.18139800
54MP0004782_abnormal_surfactant_physiolog1.17896151
55MP0001756_abnormal_urination1.17682196
56MP0005083_abnormal_biliary_tract1.16398504
57MP0005165_increased_susceptibility_to1.15864455
58MP0005330_cardiomyopathy1.15785098
59MP0010630_abnormal_cardiac_muscle1.12139107
60MP0000733_abnormal_muscle_development1.11951918
61MP0004087_abnormal_muscle_fiber1.10645326
62MP0000750_abnormal_muscle_regeneration1.10571547
63MP0002796_impaired_skin_barrier1.08533412
64MP0005666_abnormal_adipose_tissue1.07348997
65MP0004264_abnormal_extraembryonic_tissu1.07142636
66MP0004883_abnormal_blood_vessel1.06809392
67MP0005385_cardiovascular_system_phenoty1.06344206
68MP0001544_abnormal_cardiovascular_syste1.06344206
69MP0002128_abnormal_blood_circulation1.06238428
70MP0001614_abnormal_blood_vessel1.06119744
71MP0004130_abnormal_muscle_cell1.06117092
72MP0003453_abnormal_keratinocyte_physiol1.06005039
73MP0009643_abnormal_urine_homeostasis1.05699556
74MP0001915_intracranial_hemorrhage1.05079046
75MP0003115_abnormal_respiratory_system1.04252102
76MP0000003_abnormal_adipose_tissue1.03774686
77MP0005076_abnormal_cell_differentiation1.03379087
78MP0005375_adipose_tissue_phenotype1.00600632
79MP0005595_abnormal_vascular_smooth0.99388426
80MP0004036_abnormal_muscle_relaxation0.98738704
81MP0005503_abnormal_tendon_morphology0.97976698
82MP0005451_abnormal_body_composition0.97294699
83MP0002972_abnormal_cardiac_muscle0.97157763
84MP0009840_abnormal_foam_cell0.95884899
85MP0009931_abnormal_skin_appearance0.95663066
86MP0001542_abnormal_bone_strength0.95318324
87MP0000249_abnormal_blood_vessel0.94544064
88MP0005360_urolithiasis0.94449356
89MP0003315_abnormal_perineum_morphology0.93665833
90MP0003252_abnormal_bile_duct0.93635738
91MP0001348_abnormal_lacrimal_gland0.93534049
92MP0001661_extended_life_span0.93401583
93MP0002925_abnormal_cardiovascular_devel0.92881895
94MP0002896_abnormal_bone_mineralization0.92388738
95MP0000343_altered_response_to0.92015117
96MP0000858_altered_metastatic_potential0.90624587
97MP0003950_abnormal_plasma_membrane0.89577423
98MP0005501_abnormal_skin_physiology0.86605042
99MP0002254_reproductive_system_inflammat0.86351311
100MP0003045_fibrosis0.85018476
101MP0001881_abnormal_mammary_gland0.84872381
102MP0000749_muscle_degeneration0.84779985
103MP0000627_abnormal_mammary_gland0.84732026
104MP0005620_abnormal_muscle_contractility0.84062652
105MP0000538_abnormal_urinary_bladder0.83496653
106MP0002136_abnormal_kidney_physiology0.83111050
107MP0003191_abnormal_cellular_cholesterol0.82993717
108MP0008260_abnormal_autophagy0.82653762
109MP0004381_abnormal_hair_follicle0.81645269
110MP0004019_abnormal_vitamin_homeostasis0.80743594
111MP0004947_skin_inflammation0.80708415
112MP0009278_abnormal_bone_marrow0.80517114
113MP0002086_abnormal_extraembryonic_tissu0.80189847
114MP0005508_abnormal_skeleton_morphology0.79208642
115MP0003567_abnormal_fetal_cardiomyocyte0.78444128
116MP0000462_abnormal_digestive_system0.77254795
117MP0000751_myopathy0.75752894
118MP0002269_muscular_atrophy0.74901020
119MP0002135_abnormal_kidney_morphology0.73883100
120MP0003984_embryonic_growth_retardation0.72502428
121MP0002088_abnormal_embryonic_growth/wei0.70641412
122MP0004484_altered_response_of0.70556119
123MP0004858_abnormal_nervous_system0.70385312
124MP0000266_abnormal_heart_morphology0.70290012
125MP0005193_abnormal_anterior_eye0.69484380
126MP0001849_ear_inflammation0.69325046
127MP0003942_abnormal_urinary_system0.69201894
128MP0005332_abnormal_amino_acid0.68832985
129MP0002168_other_aberrant_phenotype0.68516536
130MP0005408_hypopigmentation0.67813727
131MP0002089_abnormal_postnatal_growth/wei0.67495653
132MP0004215_abnormal_myocardial_fiber0.66192235
133MP0005197_abnormal_uvea_morphology0.65050190
134MP0001191_abnormal_skin_condition0.62245813

Predicted human phenotypes

RankGene SetZ-score
1Fragile nails (HP:0001808)6.65339320
2Plantar hyperkeratosis (HP:0007556)5.51330781
3Premature rupture of membranes (HP:0001788)5.51033104
4Protrusio acetabuli (HP:0003179)5.15517788
5Cerebral aneurysm (HP:0004944)4.39208481
6Right ventricular cardiomyopathy (HP:0011663)4.31598550
7Thick nail (HP:0001805)4.30846809
8Nail dystrophy (HP:0008404)3.97388785
9Aortic aneurysm (HP:0004942)3.96695653
10Ridged nail (HP:0001807)3.85420899
11Aortic dissection (HP:0002647)3.80793289
12Shallow orbits (HP:0000586)3.80769840
13Atrophic scars (HP:0001075)3.66374207
14Pterygium (HP:0001059)3.64701266
15Abnormality of nail color (HP:0100643)3.55479555
16Increased connective tissue (HP:0009025)3.42428225
17Muscle fiber splitting (HP:0003555)3.39277569
18Palmoplantar hyperkeratosis (HP:0000972)3.30092214
19Ankle contracture (HP:0006466)3.27737036
20Aplasia cutis congenita (HP:0001057)3.24396958
21Hypoplasia of dental enamel (HP:0006297)3.22216378
22Focal segmental glomerulosclerosis (HP:0000097)3.21071854
23Abnormal blistering of the skin (HP:0008066)3.19956302
24Cervical subluxation (HP:0003308)3.11538715
25Selective tooth agenesis (HP:0001592)3.08370561
26Palmar hyperkeratosis (HP:0010765)3.04196746
27Broad metatarsal (HP:0001783)3.00505326
28Abnormal hair laboratory examination (HP:0003328)2.98938310
29Aneurysm (HP:0002617)2.95285601
30Distal lower limb amyotrophy (HP:0008944)2.89218039
31Glomerulosclerosis (HP:0000096)2.83985911
32Esophageal varix (HP:0002040)2.76127896
33Peritonitis (HP:0002586)2.76032072
34Polycythemia (HP:0001901)2.68700107
35Fragile skin (HP:0001030)2.65893189
36Ankyloglossia (HP:0010296)2.64499505
37Chondrocalcinosis (HP:0000934)2.62924039
38Spinal rigidity (HP:0003306)2.62858914
39Natal tooth (HP:0000695)2.58189993
40Short nail (HP:0001799)2.54780391
41Ventricular tachycardia (HP:0004756)2.54643976
42Difficulty climbing stairs (HP:0003551)2.53345414
43Advanced eruption of teeth (HP:0006288)2.50916664
44Lymphangioma (HP:0100764)2.50735012
45Hyporeflexia of lower limbs (HP:0002600)2.50307094
46Dilatation of the ascending aorta (HP:0005111)2.48405671
47Trismus (HP:0000211)2.46452087
48Abnormality of proline metabolism (HP:0010907)2.44481653
49Hydroxyprolinuria (HP:0003080)2.44481653
50Upper limb amyotrophy (HP:0009129)2.43229912
51Distal upper limb amyotrophy (HP:0007149)2.43229912
52Radial bowing (HP:0002986)2.40899749
53Wormian bones (HP:0002645)2.40374827
54Abnormality of Sharpey fibers (HP:0100685)2.39295464
55Interstitial pulmonary disease (HP:0006530)2.38474438
56Mesangial abnormality (HP:0001966)2.32764662
57Abnormality of oral frenula (HP:0000190)2.32214723
58Mildly elevated creatine phosphokinase (HP:0008180)2.31583459
59Hypotrichosis (HP:0001006)2.31271492
60Mitral valve prolapse (HP:0001634)2.30003278
61Abnormality of dentin (HP:0010299)2.29050459
62Deep venous thrombosis (HP:0002625)2.29036613
63Bowed forearm bones (HP:0003956)2.28171581
64Bowing of the arm (HP:0006488)2.28171581
65Flat acetabular roof (HP:0003180)2.24970431
66Nonimmune hydrops fetalis (HP:0001790)2.24885909
67Woolly hair (HP:0002224)2.22203891
68Vascular tortuosity (HP:0004948)2.20804299
69Soft skin (HP:0000977)2.20410220
70Blue sclerae (HP:0000592)2.19240205
71Thin bony cortex (HP:0002753)2.19054719
72Neonatal death (HP:0003811)2.17377243
73Increased mean platelet volume (HP:0011877)2.15790917
74Knee flexion contracture (HP:0006380)2.11327575
75Micronodular cirrhosis (HP:0001413)2.09758102
76Gout (HP:0001997)2.09228780
77Hand muscle atrophy (HP:0009130)2.08418047
78Ulnar bowing (HP:0003031)2.07968137
79Distal lower limb muscle weakness (HP:0009053)2.06445819
80Anonychia (HP:0001798)2.03531680
81Scapular winging (HP:0003691)2.02616291
82Oligodontia (HP:0000677)2.01873517
83Retinal atrophy (HP:0001105)2.01503345
84Bladder diverticulum (HP:0000015)2.00167425
85Ileus (HP:0002595)1.98522492
86Increased variability in muscle fiber diameter (HP:0003557)1.98474534
87Popliteal pterygium (HP:0009756)1.97658154
88Abnormality of the calcaneus (HP:0008364)1.96619225
89Ureteral stenosis (HP:0000071)1.95957388
90Fatigable weakness (HP:0003473)1.95710655
91Abnormality of the neuromuscular junction (HP:0003398)1.95710655
92Reduced subcutaneous adipose tissue (HP:0003758)1.95418763
93Sparse scalp hair (HP:0002209)1.95159190
94Osteolytic defects of the phalanges of the hand (HP:0009771)1.94535202
95Osteolytic defects of the hand bones (HP:0009699)1.94535202
96Gastrointestinal dysmotility (HP:0002579)1.93568564
97Abnormality of carpal bone ossification (HP:0006257)1.92741553
98Bronchomalacia (HP:0002780)1.91675113
99Elbow flexion contracture (HP:0002987)1.91286417
100Vertebral compression fractures (HP:0002953)1.89959104
101Coxa vara (HP:0002812)1.89083281
102Arterial tortuosity (HP:0005116)1.89071031
103Broad face (HP:0000283)1.88847500
104Type 1 muscle fiber predominance (HP:0003803)1.87613059
105Ectopia lentis (HP:0001083)1.87422656
106Onycholysis (HP:0001806)1.87418040
107Sudden death (HP:0001699)1.86661925
108Sparse eyelashes (HP:0000653)1.86209763
109Back pain (HP:0003418)1.85414843
110Wrist flexion contracture (HP:0001239)1.84745583
111Cerebellar dysplasia (HP:0007033)1.83494045
112Vascular calcification (HP:0004934)1.82629719
113Abnormality of the distal phalanges of the toes (HP:0010182)1.82513513
114Alopecia of scalp (HP:0002293)1.82269041
115Abnormality of skeletal muscle fiber size (HP:0012084)1.81338118
116Axonal loss (HP:0003447)1.80765597
117Abnormality of glutamine family amino acid metabolism (HP:0010902)1.80573401
118Visceral angiomatosis (HP:0100761)1.78654859
119Lipoatrophy (HP:0100578)1.78566941
120Lower limb amyotrophy (HP:0007210)1.78558300
121Abnormal platelet volume (HP:0011876)1.78437892
122Difficulty running (HP:0009046)1.78147250
123Absent eyelashes (HP:0000561)1.78142330
124Hematochezia (HP:0002573)1.78073524
125Palmoplantar keratoderma (HP:0000982)1.77931441
126Abnormal delivery (HP:0001787)1.77913377
127Long toe (HP:0010511)1.77845894
128Abnormal hemoglobin (HP:0011902)1.77730579
129Abnormality of the acetabulum (HP:0003170)1.77168111
130Camptodactyly of toe (HP:0001836)1.76831129
131Neonatal short-limb short stature (HP:0008921)1.75715729
132Acanthosis nigricans (HP:0000956)1.75616805
133Milia (HP:0001056)1.75090474
134Stridor (HP:0010307)1.74622427
135Ureteral obstruction (HP:0006000)1.74510349
136Amelogenesis imperfecta (HP:0000705)1.74281679
137Short hallux (HP:0010109)1.74143967
138Hemorrhage of the eye (HP:0011885)1.73485748
139Hypoplasia of the iris (HP:0007676)1.71610486
140Pili torti (HP:0003777)1.71172156
141Abnormal ossification of hand bones (HP:0005921)1.70278663
142Hypodontia (HP:0000668)1.69299446
143Femoral bowing (HP:0002980)1.68570711
144Abnormality of the salivary glands (HP:0010286)1.67070047
145Hemangiomatosis (HP:0007461)1.65802757
146Cardiovascular calcification (HP:0011915)1.65058180
147Lip pit (HP:0100267)1.59469512
148Polygenic inheritance (HP:0010982)1.59411296
149Glucose intolerance (HP:0000833)1.58822567
150Carious teeth (HP:0000670)1.58624302
151Hoarse voice (HP:0001609)1.56960925
152Laryngomalacia (HP:0001601)1.56894602
153Dry hair (HP:0011359)1.55115623
154Syncope (HP:0001279)1.54788878
155Polar cataract (HP:0010696)1.52560999
156Abnormal vertebral ossification (HP:0100569)1.52307518
157Insulin resistance (HP:0000855)1.51839890

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.95181089
2TRIB33.97307666
3TTN3.61822070
4TIE12.95480832
5MYLK2.86300987
6PKN22.84408832
7ERN12.63769675
8PDGFRA2.24372444
9TGFBR22.18013408
10KDR2.15228336
11RIPK12.08392003
12EPHB22.04645662
13LRRK21.97509155
14PTK61.96601322
15MAP3K31.94625857
16PTK21.92571380
17ARAF1.89229037
18PAK41.87930702
19NTRK11.82810462
20MST41.81337057
21FER1.77462351
22IRAK31.73756703
23TESK11.69175848
24DDR21.67313955
25MST1R1.63459586
26STK101.61846647
27LATS11.53666415
28PAK21.53439624
29MAP2K31.53048972
30MET1.49501181
31RPS6KB21.40612174
32DMPK1.33775072
33LATS21.32052661
34EPHB11.31075603
35MAP3K21.25335290
36TGFBR11.23629463
37STK38L1.22500581
38PAK31.21890240
39SMG11.18927890
40MAP3K111.16303400
41TRPM71.15728934
42SIK11.15595286
43PRKG21.13034403
44LIMK11.12578288
45BMX1.12158339
46PTK2B1.10912101
47ILK1.10795121
48FGFR41.09068096
49MAPKAPK31.03161502
50MAP2K11.02280508
51STK241.01290018
52MAP3K90.98792822
53PIK3CA0.98103577
54EEF2K0.94779248
55ICK0.91765461
56PIM20.90713246
57MAP3K60.89158080
58MAP2K20.87295684
59MAP3K80.86711417
60BCKDK0.83138127
61DAPK30.80985560
62PDGFRB0.80066860
63TAOK10.79989372
64NEK90.79728474
65WNK40.76748896
66NME20.76582238
67ROCK10.75622499
68RPS6KA20.75507535
69RPS6KA40.75182790
70PHKG10.72306621
71PHKG20.72306621
72MTOR0.69220962
73NEK10.66580687
74PDK20.65133214
75LMTK20.63792613
76PRKCI0.62368389
77PRKD10.61495315
78MAP3K120.61070430
79TAOK20.60264791
80PRKD20.59842614
81PDK30.59684472
82PDK40.59684472
83STK30.57977032
84PAK10.55184184
85ABL20.55168921
86FRK0.54653479
87PIK3CG0.54322403
88FGFR10.51287910
89CDC42BPA0.50126667
90SCYL20.49759070
91KSR20.47790101
92RET0.47739145
93TBK10.45633261
94FLT30.44728987
95ROCK20.44694919
96RPS6KC10.43700100
97RPS6KL10.43700100
98CDK60.42670245
99CAMK2G0.42504093
100DYRK1B0.41990669
101PRKAA20.41600174
102EGFR0.38818175
103CSK0.38569889
104GSK3A0.38568834
105CAMK1D0.38422624
106ERBB40.37581035
107AKT20.37324901
108STK390.37222874
109MAPKAPK20.36394739
110CDK90.35680143
111INSR0.34339850
112MAP3K70.33729437
113MATK0.32927668
114MAP3K130.32368728
115MOS0.32289328
116CDK80.31954713
117JAK30.31896860
118RPS6KA60.31581786
119MAP3K10.31476904
120BRAF0.31320469
121CAMK2D0.30868511
122SRC0.29896274
123MAP3K100.29126283
124PDPK10.29032858
125MAP2K60.29025398
126MUSK0.26660279
127STK380.26565675
128ZAP700.25622864
129CDK120.25391196
130ERBB20.25284504
131MARK20.23531313
132NME10.23016109
133CAMK2B0.22627463
134PRKCE0.21682295

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.98868464
2Focal adhesion_Homo sapiens_hsa045102.93026106
3Small cell lung cancer_Homo sapiens_hsa052222.85141241
4Amoebiasis_Homo sapiens_hsa051462.33154364
5Bladder cancer_Homo sapiens_hsa052192.24452638
6Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.18562027
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.11902326
8Adherens junction_Homo sapiens_hsa045202.08251619
9Leukocyte transendothelial migration_Homo sapiens_hsa046702.05485609
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.95251274
11Proteoglycans in cancer_Homo sapiens_hsa052051.90899739
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.89973615
13Tight junction_Homo sapiens_hsa045301.84061260
14Cyanoamino acid metabolism_Homo sapiens_hsa004601.77927546
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.75992779
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.71671947
17Phenylalanine metabolism_Homo sapiens_hsa003601.70311653
18Dilated cardiomyopathy_Homo sapiens_hsa054141.67951353
19Fatty acid degradation_Homo sapiens_hsa000711.65840193
20Hippo signaling pathway_Homo sapiens_hsa043901.56649852
21PPAR signaling pathway_Homo sapiens_hsa033201.47036707
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.45645062
23Toxoplasmosis_Homo sapiens_hsa051451.36515765
24Caffeine metabolism_Homo sapiens_hsa002321.32662973
25Protein digestion and absorption_Homo sapiens_hsa049741.30394161
26Axon guidance_Homo sapiens_hsa043601.26286741
27Regulation of actin cytoskeleton_Homo sapiens_hsa048101.23170171
28Complement and coagulation cascades_Homo sapiens_hsa046101.22355284
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20972919
30PI3K-Akt signaling pathway_Homo sapiens_hsa041511.18718073
31Fatty acid metabolism_Homo sapiens_hsa012121.14733393
32Histidine metabolism_Homo sapiens_hsa003401.14387889
33Carbon metabolism_Homo sapiens_hsa012001.13755476
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12127281
35Fructose and mannose metabolism_Homo sapiens_hsa000511.09662512
36Shigellosis_Homo sapiens_hsa051311.08636741
37Glycerolipid metabolism_Homo sapiens_hsa005611.03745346
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02064997
39Chronic myeloid leukemia_Homo sapiens_hsa052200.99483552
40Bile secretion_Homo sapiens_hsa049760.98803601
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98297676
42Propanoate metabolism_Homo sapiens_hsa006400.98275913
43Prion diseases_Homo sapiens_hsa050200.96567737
44MicroRNAs in cancer_Homo sapiens_hsa052060.94484935
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92749327
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92507253
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92278127
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91962237
49Insulin signaling pathway_Homo sapiens_hsa049100.91280146
50Rap1 signaling pathway_Homo sapiens_hsa040150.91102666
51Platelet activation_Homo sapiens_hsa046110.89167538
52Fatty acid biosynthesis_Homo sapiens_hsa000610.89074556
53Pathways in cancer_Homo sapiens_hsa052000.87493947
54Tryptophan metabolism_Homo sapiens_hsa003800.85543139
55TGF-beta signaling pathway_Homo sapiens_hsa043500.84908333
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84668787
57Galactose metabolism_Homo sapiens_hsa000520.84193671
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82774239
59Glutathione metabolism_Homo sapiens_hsa004800.82414962
60Ovarian steroidogenesis_Homo sapiens_hsa049130.82070258
61p53 signaling pathway_Homo sapiens_hsa041150.81969521
62Arginine biosynthesis_Homo sapiens_hsa002200.81722642
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81298806
64Malaria_Homo sapiens_hsa051440.80729718
65HIF-1 signaling pathway_Homo sapiens_hsa040660.79256322
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.78216505
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.77808807
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77320933
69Nitrogen metabolism_Homo sapiens_hsa009100.76595266
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76016270
71ErbB signaling pathway_Homo sapiens_hsa040120.75442252
72Insulin resistance_Homo sapiens_hsa049310.74128381
73Thyroid cancer_Homo sapiens_hsa052160.73635016
74Chemical carcinogenesis_Homo sapiens_hsa052040.73128945
75Viral myocarditis_Homo sapiens_hsa054160.72598951
76Tyrosine metabolism_Homo sapiens_hsa003500.71324913
77Pancreatic cancer_Homo sapiens_hsa052120.70711685
78Pyruvate metabolism_Homo sapiens_hsa006200.70459009
79Fat digestion and absorption_Homo sapiens_hsa049750.70218529
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70036031
81GnRH signaling pathway_Homo sapiens_hsa049120.69085293
82Sulfur metabolism_Homo sapiens_hsa009200.68909849
83N-Glycan biosynthesis_Homo sapiens_hsa005100.68059250
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67455450
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66581637
86Sulfur relay system_Homo sapiens_hsa041220.66458275
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65992357
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64951545
89Renin secretion_Homo sapiens_hsa049240.64935560
90Starch and sucrose metabolism_Homo sapiens_hsa005000.63601892
91Vitamin digestion and absorption_Homo sapiens_hsa049770.63487729
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62230547
93AMPK signaling pathway_Homo sapiens_hsa041520.62048783
94Sphingolipid metabolism_Homo sapiens_hsa006000.60752588
95Melanoma_Homo sapiens_hsa052180.59821927
96Pancreatic secretion_Homo sapiens_hsa049720.59421621
97Salmonella infection_Homo sapiens_hsa051320.57258599
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.57017290
99Basal cell carcinoma_Homo sapiens_hsa052170.56362962
100Renal cell carcinoma_Homo sapiens_hsa052110.56081115
101TNF signaling pathway_Homo sapiens_hsa046680.55804049
102Lysosome_Homo sapiens_hsa041420.55201157
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.55018806
104Apoptosis_Homo sapiens_hsa042100.54894552
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54782828
106Glucagon signaling pathway_Homo sapiens_hsa049220.54653840
107Arginine and proline metabolism_Homo sapiens_hsa003300.53886269
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.52726145
109VEGF signaling pathway_Homo sapiens_hsa043700.52300962
110Endocytosis_Homo sapiens_hsa041440.50825717
111Retinol metabolism_Homo sapiens_hsa008300.50515078
112Biosynthesis of amino acids_Homo sapiens_hsa012300.50436032
113Dorso-ventral axis formation_Homo sapiens_hsa043200.50125059
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49367337
115Renin-angiotensin system_Homo sapiens_hsa046140.49352297
116Prostate cancer_Homo sapiens_hsa052150.49039809
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47323962
118Other glycan degradation_Homo sapiens_hsa005110.46656814
119Vibrio cholerae infection_Homo sapiens_hsa051100.46299743
120Lysine degradation_Homo sapiens_hsa003100.46141817
121Pentose phosphate pathway_Homo sapiens_hsa000300.45674233
122Hepatitis C_Homo sapiens_hsa051600.45636349
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.45064008
124Inositol phosphate metabolism_Homo sapiens_hsa005620.44910037
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.44630218
126Mineral absorption_Homo sapiens_hsa049780.44372968
127beta-Alanine metabolism_Homo sapiens_hsa004100.43198704
128HTLV-I infection_Homo sapiens_hsa051660.41943093
129Endometrial cancer_Homo sapiens_hsa052130.41707201
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.41313626
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40377924
132Notch signaling pathway_Homo sapiens_hsa043300.39488460
133Thyroid hormone synthesis_Homo sapiens_hsa049180.39037277

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