TIPRL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.94879401
2energy coupled proton transport, down electrochemical gradient (GO:0015985)4.71270042
3ATP synthesis coupled proton transport (GO:0015986)4.71270042
4protein neddylation (GO:0045116)4.50865541
5ribosome assembly (GO:0042255)4.50015624
6GTP biosynthetic process (GO:0006183)4.46042150
7chaperone-mediated protein transport (GO:0072321)4.45513902
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.44431777
9nuclear pore complex assembly (GO:0051292)4.43413269
10nuclear pore organization (GO:0006999)4.21962138
11cullin deneddylation (GO:0010388)4.13428502
12DNA double-strand break processing (GO:0000729)4.13069357
13termination of RNA polymerase III transcription (GO:0006386)4.04870401
14transcription elongation from RNA polymerase III promoter (GO:0006385)4.04870401
15protein deneddylation (GO:0000338)3.95050066
167-methylguanosine RNA capping (GO:0009452)3.86231066
17RNA capping (GO:0036260)3.86231066
18establishment of protein localization to mitochondrial membrane (GO:0090151)3.82705606
197-methylguanosine mRNA capping (GO:0006370)3.81348546
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.78592418
21NADH dehydrogenase complex assembly (GO:0010257)3.78592418
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.78592418
23mitotic sister chromatid cohesion (GO:0007064)3.77465319
24guanosine-containing compound biosynthetic process (GO:1901070)3.73934107
25UTP biosynthetic process (GO:0006228)3.73081505
26protein complex biogenesis (GO:0070271)3.70476760
27amino acid activation (GO:0043038)3.67481633
28tRNA aminoacylation (GO:0043039)3.67481633
29tRNA aminoacylation for protein translation (GO:0006418)3.67037515
30formation of translation preinitiation complex (GO:0001731)3.61192346
31regulation of feeding behavior (GO:0060259)3.58649826
32non-recombinational repair (GO:0000726)3.57794400
33double-strand break repair via nonhomologous end joining (GO:0006303)3.57794400
34respiratory electron transport chain (GO:0022904)3.57774341
35CENP-A containing nucleosome assembly (GO:0034080)3.54958102
36proteasome assembly (GO:0043248)3.51731006
37electron transport chain (GO:0022900)3.50446495
38regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.46043480
39pore complex assembly (GO:0046931)3.44566852
40ribonucleoprotein complex disassembly (GO:0032988)3.40515048
41DNA catabolic process, exonucleolytic (GO:0000738)3.40367926
42neuron cell-cell adhesion (GO:0007158)3.37894877
43oxidative phosphorylation (GO:0006119)3.37386573
44sister chromatid segregation (GO:0000819)3.37208812
45microtubule depolymerization (GO:0007019)3.36882137
46purine nucleobase biosynthetic process (GO:0009113)3.36674924
47transcription elongation from RNA polymerase I promoter (GO:0006362)3.36193967
48chromatin remodeling at centromere (GO:0031055)3.33438130
49kinetochore organization (GO:0051383)3.33188752
50somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.33091598
51somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.33091598
52isotype switching (GO:0045190)3.33091598
53mitotic metaphase plate congression (GO:0007080)3.32739321
54regulation of mitochondrial translation (GO:0070129)3.32532777
55regulation of ubiquitin-protein transferase activity (GO:0051438)3.30608975
56protein localization to kinetochore (GO:0034501)3.30239972
57resolution of meiotic recombination intermediates (GO:0000712)3.30007481
58mitochondrial respiratory chain complex assembly (GO:0033108)3.29534663
59mitotic sister chromatid segregation (GO:0000070)3.27554950
60metaphase plate congression (GO:0051310)3.25049202
61DNA ligation (GO:0006266)3.20961661
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.18713049
63nucleobase-containing small molecule interconversion (GO:0015949)3.18278861
64negative regulation of appetite (GO:0032099)3.17426706
65negative regulation of response to food (GO:0032096)3.17426706
66regulation of ligase activity (GO:0051340)3.17084358
67spindle checkpoint (GO:0031577)3.13684347
68transcription from mitochondrial promoter (GO:0006390)3.13431114
69protein localization to chromosome, centromeric region (GO:0071459)3.13380982
70histone exchange (GO:0043486)3.13141849
71establishment of chromosome localization (GO:0051303)3.11584880
72ribosomal large subunit biogenesis (GO:0042273)3.11441360
73mitotic spindle checkpoint (GO:0071174)3.11313009
74deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.10537046
75presynaptic membrane assembly (GO:0097105)3.06180854
76ribosomal small subunit biogenesis (GO:0042274)3.05843111
77positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.05833138
78microtubule polymerization or depolymerization (GO:0031109)3.04134012
79positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.03304277
80protein targeting to mitochondrion (GO:0006626)3.02980822
81termination of RNA polymerase I transcription (GO:0006363)3.02851299
82protein K11-linked ubiquitination (GO:0070979)3.02035835
83nucleoside diphosphate phosphorylation (GO:0006165)3.01351436
84UTP metabolic process (GO:0046051)3.00236026
85drinking behavior (GO:0042756)2.99575000
86pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.98768314
87organelle disassembly (GO:1903008)2.98221088
88establishment of protein localization to mitochondrion (GO:0072655)2.98010344
89de novo protein folding (GO:0006458)2.97291654
90de novo posttranslational protein folding (GO:0051084)2.95392507
91negative regulation of ligase activity (GO:0051352)2.93889792
92negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.93889792
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.93103958
94ribosome biogenesis (GO:0042254)2.93054842
95regulation of cellular amino acid metabolic process (GO:0006521)2.92990216
96CTP metabolic process (GO:0046036)2.92504351
97CTP biosynthetic process (GO:0006241)2.92504351
98kinetochore assembly (GO:0051382)2.92246361
99histone mRNA metabolic process (GO:0008334)2.90392833
100anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.88519871
101nucleobase biosynthetic process (GO:0046112)2.87964326
102exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87420614
103regulation of DNA endoreduplication (GO:0032875)2.86985916
104mitotic spindle assembly checkpoint (GO:0007094)2.86953193
105RNA-dependent DNA replication (GO:0006278)2.86179518
106DNA strand elongation involved in DNA replication (GO:0006271)2.85119141
107telomere maintenance via telomerase (GO:0007004)2.84581297
108negative regulation of protein ubiquitination (GO:0031397)2.84197607
109replication fork processing (GO:0031297)2.84121778
110spindle assembly checkpoint (GO:0071173)2.83295230
111negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.82866499
112negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.82866499
113negative regulation of mitotic sister chromatid segregation (GO:0033048)2.82866499
114negative regulation of mitotic sister chromatid separation (GO:2000816)2.82866499
115negative regulation of sister chromatid segregation (GO:0033046)2.82866499
116postreplication repair (GO:0006301)2.82844097
117mitotic nuclear envelope disassembly (GO:0007077)2.82805410
118presynaptic membrane organization (GO:0097090)2.76616141
119transcription elongation from RNA polymerase II promoter (GO:0006368)2.76432812
120maturation of 5.8S rRNA (GO:0000460)2.74782235
121protein localization to mitochondrion (GO:0070585)2.71516959
122protein-cofactor linkage (GO:0018065)2.70158763
123transcription from RNA polymerase I promoter (GO:0006360)2.69481754
124DNA-templated transcription, elongation (GO:0006354)2.69081057
125DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.68977308
126spliceosomal complex assembly (GO:0000245)2.67734142
127positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.67368821
128spliceosomal snRNP assembly (GO:0000387)2.66991718
129signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.62885917
130intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.62885917
131establishment of integrated proviral latency (GO:0075713)2.61810748
132signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.61364072
133signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.61364072
134signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.61364072
135deoxyribonucleotide biosynthetic process (GO:0009263)2.60997987
136purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.59758535
137protein localization to cilium (GO:0061512)2.59263906
138L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.58666861
139positive regulation of ligase activity (GO:0051351)2.58092884
140regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.57798235
141positive regulation of protein homodimerization activity (GO:0090073)2.57435199
142establishment of viral latency (GO:0019043)2.57165778
143axon ensheathment in central nervous system (GO:0032291)2.55439359
144central nervous system myelination (GO:0022010)2.55439359
145deoxyribose phosphate biosynthetic process (GO:0046385)2.54496838
1462-deoxyribonucleotide biosynthetic process (GO:0009265)2.54496838
147transcription initiation from RNA polymerase I promoter (GO:0006361)2.53743274
148DNA damage response, detection of DNA damage (GO:0042769)2.52888229
149peptidyl-histidine modification (GO:0018202)2.52360706
150substantia nigra development (GO:0021762)2.51711838
151regulation of appetite (GO:0032098)2.51628906
152signal transduction involved in DNA integrity checkpoint (GO:0072401)2.51591580
153signal transduction involved in DNA damage checkpoint (GO:0072422)2.51591580
154viral mRNA export from host cell nucleus (GO:0046784)2.51494756
155purine nucleoside triphosphate biosynthetic process (GO:0009145)2.51026422
156signal transduction involved in cell cycle checkpoint (GO:0072395)2.49732728
157pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.49235731
158pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.48929638
159long-chain fatty acid biosynthetic process (GO:0042759)2.48019565
160nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.47857992
161positive regulation of viral transcription (GO:0050434)2.47797523
162positive regulation of vascular permeability (GO:0043117)2.44787026
163spermatid nucleus differentiation (GO:0007289)2.44072150
164maturation of SSU-rRNA (GO:0030490)2.42867432
165postsynaptic membrane organization (GO:0001941)2.42606726

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.42601190
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.75183334
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.55138584
4* GABP_17652178_ChIP-ChIP_JURKAT_Human3.39697346
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.26242676
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.00002870
7EZH2_22144423_ChIP-Seq_EOC_Human2.98202954
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.75801936
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.74598281
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.67925635
11FUS_26573619_Chip-Seq_HEK293_Human2.59996832
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58291215
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.56832006
14TAF15_26573619_Chip-Seq_HEK293_Human2.50697485
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.49688704
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.41748221
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35618518
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.28151415
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.27845566
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24689249
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19905822
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17009261
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14912308
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.07752124
25AR_21909140_ChIP-Seq_LNCAP_Human2.06411790
26VDR_22108803_ChIP-Seq_LS180_Human2.04625761
27GBX2_23144817_ChIP-Seq_PC3_Human2.03356664
28FLI1_27457419_Chip-Seq_LIVER_Mouse2.02361494
29* ELK1_19687146_ChIP-ChIP_HELA_Human2.00276318
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98104476
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96042517
32VDR_23849224_ChIP-Seq_CD4+_Human1.94051034
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85930671
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83721463
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.78814478
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78486140
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.76410029
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75356045
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73863345
40EWS_26573619_Chip-Seq_HEK293_Human1.72716990
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70285404
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70141794
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.69294574
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63101301
45* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62795676
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62771228
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.61812500
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55483409
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.54520134
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53065670
51P300_19829295_ChIP-Seq_ESCs_Human1.51325996
52RNF2_27304074_Chip-Seq_NSC_Mouse1.50977656
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.50324989
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.49337054
55DCP1A_22483619_ChIP-Seq_HELA_Human1.49048303
56IGF1R_20145208_ChIP-Seq_DFB_Human1.42782894
57ER_23166858_ChIP-Seq_MCF-7_Human1.41319066
58TTF2_22483619_ChIP-Seq_HELA_Human1.41073477
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.41031696
60FOXP3_21729870_ChIP-Seq_TREG_Human1.40800020
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39768922
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30589320
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28643584
64TFEB_21752829_ChIP-Seq_HELA_Human1.28476082
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27436091
66MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27402333
67* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.27300719
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.27041354
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26670145
70KDM5A_27292631_Chip-Seq_BREAST_Human1.25623319
71* ELK1_22589737_ChIP-Seq_MCF10A_Human1.24864477
72EZH2_27304074_Chip-Seq_ESCs_Mouse1.22126375
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21449434
74* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20226909
75IRF1_19129219_ChIP-ChIP_H3396_Human1.20112415
76* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.19853395
77JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17521729
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16959681
79MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16174440
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15956491
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15867996
82CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.13894562
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13554262
84* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12382237
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12271579
86XRN2_22483619_ChIP-Seq_HELA_Human1.11466588
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10958949
88* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10942421
89* NANOG_18555785_Chip-Seq_ESCs_Mouse1.09622916
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09107059
91* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07181942
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06377474
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05818118
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04069748
95PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03766730
96SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02784913
97* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02642424
98JUN_21703547_ChIP-Seq_K562_Human1.02188385
99REST_21632747_ChIP-Seq_MESCs_Mouse1.01887919
100* GABP_19822575_ChIP-Seq_HepG2_Human1.01421368
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01116083
102NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00901090
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00693427
104* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99887056
105FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.98377163
106* SOX17_20123909_ChIP-Seq_XEN_Mouse0.96834942
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96548354
108CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96438589
109* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94798143
110MYC_18940864_ChIP-ChIP_HL60_Human0.94539744
111PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94066135
112NFE2_27457419_Chip-Seq_LIVER_Mouse0.94046516
113* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93477947
114* P53_22387025_ChIP-Seq_ESCs_Mouse0.93262183
115SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.93091297
116* P300_18555785_Chip-Seq_ESCs_Mouse0.92699303
117WT1_19549856_ChIP-ChIP_CCG9911_Human0.92373867
118* STAT3_18555785_Chip-Seq_ESCs_Mouse0.92289759
119ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90850531
120EGR1_19374776_ChIP-ChIP_THP-1_Human0.90657716
121* CMYC_18555785_Chip-Seq_ESCs_Mouse0.89610897
122SMAD4_21799915_ChIP-Seq_A2780_Human0.89338335
123* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89014041
124* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88993166
125SOX9_26525672_Chip-Seq_HEART_Mouse0.88208724
126* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87896014
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.87681967
128SMAD3_21741376_ChIP-Seq_EPCs_Human0.87437514
129ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87308522
130SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86521334
131ELF5_23300383_ChIP-Seq_T47D_Human0.85549908
132ZNF274_21170338_ChIP-Seq_K562_Hela0.85262817
133GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85076091
134* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.84578659
135CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84193021
136HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82255866
137* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.81730050
138* EZH2_27294783_Chip-Seq_NPCs_Mouse0.81303353
139FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80571691
140CIITA_25753668_ChIP-Seq_RAJI_Human0.78196110
141CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78141045
142NANOG_16153702_ChIP-ChIP_HESCs_Human0.78030298
143* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.77624878
144GATA4_21415370_ChIP-Seq_HL-1_Mouse0.76758428
145NANOG_18555785_ChIP-Seq_MESCs_Mouse0.76715465
146NOTCH1_21737748_ChIP-Seq_TLL_Human0.75535544

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.89087368
2MP0001529_abnormal_vocalization3.50241147
3MP0006276_abnormal_autonomic_nervous2.75548424
4MP0002877_abnormal_melanocyte_morpholog2.74339197
5MP0005408_hypopigmentation2.73803484
6MP0003806_abnormal_nucleotide_metabolis2.71468585
7MP0009379_abnormal_foot_pigmentation2.70680721
8MP0003221_abnormal_cardiomyocyte_apopto2.63533496
9MP0001188_hyperpigmentation2.52023089
10MP0001905_abnormal_dopamine_level2.47399765
11MP0000569_abnormal_digit_pigmentation2.45402297
12MP0006292_abnormal_olfactory_placode2.43976986
13MP0003186_abnormal_redox_activity2.17127882
14MP0001968_abnormal_touch/_nociception2.15594944
15MP0005423_abnormal_somatic_nervous2.07975810
16MP0002102_abnormal_ear_morphology2.05871887
17MP0003122_maternal_imprinting2.03859757
18MP0003136_yellow_coat_color2.01150303
19MP0002736_abnormal_nociception_after1.99679412
20MP0002163_abnormal_gland_morphology1.97317411
21MP0002734_abnormal_mechanical_nocicepti1.93527817
22MP0002572_abnormal_emotion/affect_behav1.90047694
23MP0000358_abnormal_cell_content/1.88825959
24MP0003635_abnormal_synaptic_transmissio1.87069993
25MP0001486_abnormal_startle_reflex1.84487153
26MP0008057_abnormal_DNA_replication1.84201597
27MP0002272_abnormal_nervous_system1.81227977
28MP0004270_analgesia1.80765624
29MP0006036_abnormal_mitochondrial_physio1.80417436
30MP0009745_abnormal_behavioral_response1.77857094
31MP0002064_seizures1.77028461
32MP0000778_abnormal_nervous_system1.75120446
33MP0002735_abnormal_chemical_nociception1.74813640
34MP0009046_muscle_twitch1.74621823
35MP0006054_spinal_hemorrhage1.71004624
36MP0000350_abnormal_cell_proliferation1.67671646
37MP0005645_abnormal_hypothalamus_physiol1.66290474
38MP0002234_abnormal_pharynx_morphology1.65467537
39MP0005379_endocrine/exocrine_gland_phen1.63608076
40MP0002063_abnormal_learning/memory/cond1.60134865
41MP0005409_darkened_coat_color1.55659836
42MP0001440_abnormal_grooming_behavior1.52326411
43MP0008058_abnormal_DNA_repair1.50218893
44MP0005171_absent_coat_pigmentation1.49111951
45MP0002822_catalepsy1.48739298
46MP0003693_abnormal_embryo_hatching1.48346693
47MP0010352_gastrointestinal_tract_polyps1.46909380
48MP0004957_abnormal_blastocyst_morpholog1.46533854
49MP0001697_abnormal_embryo_size1.45217832
50MP0006072_abnormal_retinal_apoptosis1.44239660
51MP0002184_abnormal_innervation1.44119254
52MP0010307_abnormal_tumor_latency1.43660684
53MP0008932_abnormal_embryonic_tissue1.43291547
54MP0001970_abnormal_pain_threshold1.42910674
55MP0004742_abnormal_vestibular_system1.42864598
56MP0001730_embryonic_growth_arrest1.39360447
57MP0010234_abnormal_vibrissa_follicle1.36565146
58MP0004142_abnormal_muscle_tone1.36020995
59MP0005187_abnormal_penis_morphology1.34662356
60MP0002733_abnormal_thermal_nociception1.34288710
61MP0002067_abnormal_sensory_capabilities1.34127576
62MP0003121_genomic_imprinting1.33074046
63MP0002638_abnormal_pupillary_reflex1.32829093
64MP0005386_behavior/neurological_phenoty1.32321431
65MP0004924_abnormal_behavior1.32321431
66MP0001984_abnormal_olfaction1.32001703
67MP0005410_abnormal_fertilization1.30332781
68MP0001672_abnormal_embryogenesis/_devel1.29683451
69MP0005380_embryogenesis_phenotype1.29683451
70MP0005646_abnormal_pituitary_gland1.28651539
71MP0001963_abnormal_hearing_physiology1.27503451
72MP0002751_abnormal_autonomic_nervous1.23794247
73MP0004859_abnormal_synaptic_plasticity1.21941761
74MP0001986_abnormal_taste_sensitivity1.21839859
75MP0002557_abnormal_social/conspecific_i1.20417271
76MP0002080_prenatal_lethality1.19886594
77MP0000631_abnormal_neuroendocrine_gland1.19189666
78MP0000026_abnormal_inner_ear1.18693363
79MP0005075_abnormal_melanosome_morpholog1.18159042
80MP0000313_abnormal_cell_death1.18142156
81MP0003567_abnormal_fetal_cardiomyocyte1.17500941
82MP0003984_embryonic_growth_retardation1.16749807
83MP0003787_abnormal_imprinting1.16293083
84MP0002088_abnormal_embryonic_growth/wei1.15299043
85MP0001485_abnormal_pinna_reflex1.14424127
86MP0000647_abnormal_sebaceous_gland1.14089059
87MP0002938_white_spotting1.12769240
88MP0003718_maternal_effect1.12439980
89MP0002084_abnormal_developmental_patter1.11510699
90MP0000015_abnormal_ear_pigmentation1.10891347
91MP0008877_abnormal_DNA_methylation1.10845078
92MP0002090_abnormal_vision1.10518395
93MP0003315_abnormal_perineum_morphology1.09836188
94MP0003786_premature_aging1.09724218
95MP0005451_abnormal_body_composition1.09457459
96MP0000372_irregular_coat_pigmentation1.09292707
97MP0002277_abnormal_respiratory_mucosa1.07775924
98MP0003941_abnormal_skin_development1.05545295
99MP0003938_abnormal_ear_development1.03983460
100MP0010386_abnormal_urinary_bladder1.03227984
101MP0001661_extended_life_span1.01969329
102MP0002752_abnormal_somatic_nervous1.01244325
103MP0005623_abnormal_meninges_morphology1.00928285
104MP0002882_abnormal_neuron_morphology0.98015929
105MP0005551_abnormal_eye_electrophysiolog0.96957697
106MP0003077_abnormal_cell_cycle0.96332706
107MP0004215_abnormal_myocardial_fiber0.95985997
108MP0001501_abnormal_sleep_pattern0.95812615
109MP0005248_abnormal_Harderian_gland0.95741887
110MP0003111_abnormal_nucleus_morphology0.94804450
111MP0006035_abnormal_mitochondrial_morpho0.94768448
112MP0010094_abnormal_chromosome_stability0.94426159
113MP0001727_abnormal_embryo_implantation0.94411204
114MP0005384_cellular_phenotype0.93575802
115MP0004134_abnormal_chest_morphology0.93573322
116MP0000920_abnormal_myelination0.93029365
117MP0004233_abnormal_muscle_weight0.92903447
118MP0003950_abnormal_plasma_membrane0.90208789
119MP0002085_abnormal_embryonic_tissue0.88246570
120MP0002066_abnormal_motor_capabilities/c0.88054450
121MP0001186_pigmentation_phenotype0.87682727
122MP0003698_abnormal_male_reproductive0.87455770
123MP0001919_abnormal_reproductive_system0.85248374
124MP0000371_diluted_coat_color0.84253070
125MP0003890_abnormal_embryonic-extraembry0.83523461
126MP0005253_abnormal_eye_physiology0.81707754
127MP0002837_dystrophic_cardiac_calcinosis0.81432307
128MP0001929_abnormal_gametogenesis0.80496949
129MP0001346_abnormal_lacrimal_gland0.80479983
130MP0005266_abnormal_metabolism0.80456855
131MP0000749_muscle_degeneration0.80287124
132MP0002019_abnormal_tumor_incidence0.80059169
133MP0008007_abnormal_cellular_replicative0.79244646
134MP0005367_renal/urinary_system_phenotyp0.79196819
135MP0000516_abnormal_urinary_system0.79196819
136MP0001191_abnormal_skin_condition0.78376399
137MP0002152_abnormal_brain_morphology0.76536816
138MP0002177_abnormal_outer_ear0.74290914
139MP0004197_abnormal_fetal_growth/weight/0.74222923
140MP0000427_abnormal_hair_cycle0.74003757
141MP0002086_abnormal_extraembryonic_tissu0.72936063
142MP0002006_tumorigenesis0.72483420
143MP0005084_abnormal_gallbladder_morpholo0.72440820
144MP0003123_paternal_imprinting0.72093213
145MP0005389_reproductive_system_phenotype0.71482100
146MP0008789_abnormal_olfactory_epithelium0.71043114
147MP0001299_abnormal_eye_distance/0.70793059
148MP0009697_abnormal_copulation0.70724103
149MP0002210_abnormal_sex_determination0.70583068
150MP0000049_abnormal_middle_ear0.70474519
151MP0001764_abnormal_homeostasis0.70125342
152MP0003937_abnormal_limbs/digits/tail_de0.70023935
153MP0000955_abnormal_spinal_cord0.69816619
154MP0002166_altered_tumor_susceptibility0.68864082
155MP0002160_abnormal_reproductive_system0.68520619
156MP0001502_abnormal_circadian_rhythm0.68394907
157MP0004811_abnormal_neuron_physiology0.68092233
158MP0002095_abnormal_skin_pigmentation0.67707008
159MP0002233_abnormal_nose_morphology0.67099666
160MP0008995_early_reproductive_senescence0.66928573
161MP0001243_abnormal_dermal_layer0.65442822
162MP0002229_neurodegeneration0.64711010
163MP0003861_abnormal_nervous_system0.64065612
164MP0004147_increased_porphyrin_level0.63866081

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.18587521
2Abnormal mitochondria in muscle tissue (HP:0008316)4.43884219
3Progressive macrocephaly (HP:0004481)4.29068727
4Mitochondrial inheritance (HP:0001427)4.23047207
5Acute encephalopathy (HP:0006846)3.69036459
6Volvulus (HP:0002580)3.49548327
7Increased CSF lactate (HP:0002490)3.47884045
8Medial flaring of the eyebrow (HP:0010747)3.42373345
9Gait imbalance (HP:0002141)3.35937007
10Increased hepatocellular lipid droplets (HP:0006565)3.32140095
11Hepatocellular necrosis (HP:0001404)3.23498308
12Abnormality of glycolysis (HP:0004366)3.16660042
13Increased serum pyruvate (HP:0003542)3.16660042
14Congenital primary aphakia (HP:0007707)3.15639518
15Abnormal respiratory motile cilium morphology (HP:0005938)3.15473809
16Abnormal respiratory epithelium morphology (HP:0012253)3.15473809
17Chromsome breakage (HP:0040012)3.06965993
18Abnormality of the anterior horn cell (HP:0006802)2.98714114
19Degeneration of anterior horn cells (HP:0002398)2.98714114
20Microvesicular hepatic steatosis (HP:0001414)2.95435062
21Nephrogenic diabetes insipidus (HP:0009806)2.94345306
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.93001821
23Abnormality of chromosome stability (HP:0003220)2.88646492
243-Methylglutaconic aciduria (HP:0003535)2.87877280
25Optic disc pallor (HP:0000543)2.86069584
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.84283972
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.82985035
28Cutaneous melanoma (HP:0012056)2.79699955
29Abnormal hair whorl (HP:0010721)2.79414347
30Abnormality of the labia minora (HP:0012880)2.74790229
31Renal Fanconi syndrome (HP:0001994)2.74580535
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.73820701
33Cortical dysplasia (HP:0002539)2.71625951
34Hypothermia (HP:0002045)2.71589387
35Lipid accumulation in hepatocytes (HP:0006561)2.71544968
36Abnormal ciliary motility (HP:0012262)2.68080198
37Dynein arm defect of respiratory motile cilia (HP:0012255)2.65171602
38Absent/shortened dynein arms (HP:0200106)2.65171602
39Abnormality of the preputium (HP:0100587)2.57601918
40Exercise intolerance (HP:0003546)2.56185895
41Genital tract atresia (HP:0001827)2.55362286
42Pancreatic fibrosis (HP:0100732)2.54110114
43Abnormal respiratory motile cilium physiology (HP:0012261)2.53993030
44Vaginal atresia (HP:0000148)2.53747216
45Cerebral hypomyelination (HP:0006808)2.51774176
46Hepatic necrosis (HP:0002605)2.49570811
47Limb dystonia (HP:0002451)2.49490407
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.47170877
49Meckel diverticulum (HP:0002245)2.45533128
50Leukodystrophy (HP:0002415)2.45413209
51Abnormality of the ileum (HP:0001549)2.43399259
52Hypokinesia (HP:0002375)2.40358438
53Upper limb muscle weakness (HP:0003484)2.36947375
54Exertional dyspnea (HP:0002875)2.35720206
55Rhinitis (HP:0012384)2.35162750
56Irregular epiphyses (HP:0010582)2.33715323
57Birth length less than 3rd percentile (HP:0003561)2.32060851
58Abnormality of methionine metabolism (HP:0010901)2.30016562
59Atonic seizures (HP:0010819)2.28356830
60Insidious onset (HP:0003587)2.27876508
61Termporal pattern (HP:0011008)2.27876508
62Breast hypoplasia (HP:0003187)2.27762883
63Myelodysplasia (HP:0002863)2.27304616
64Focal motor seizures (HP:0011153)2.26097313
65Renal cortical cysts (HP:0000803)2.25930733
66Postnatal microcephaly (HP:0005484)2.23898709
67Respiratory failure (HP:0002878)2.22001526
68Pancreatic cysts (HP:0001737)2.21616773
69True hermaphroditism (HP:0010459)2.20786201
70Epileptic encephalopathy (HP:0200134)2.20147347
71Shoulder girdle muscle weakness (HP:0003547)2.19824588
72Increased serum lactate (HP:0002151)2.19746589
73Decreased activity of mitochondrial respiratory chain (HP:0008972)2.19018322
74Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.19018322
75Neuroendocrine neoplasm (HP:0100634)2.17197202
76Abnormality of midbrain morphology (HP:0002418)2.13671548
77Molar tooth sign on MRI (HP:0002419)2.13671548
78Abnormality of alanine metabolism (HP:0010916)2.12827338
79Hyperalaninemia (HP:0003348)2.12827338
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12827338
81CNS demyelination (HP:0007305)2.12062150
82Poor coordination (HP:0002370)2.11897446
83Small intestinal stenosis (HP:0012848)2.11837235
84Duodenal stenosis (HP:0100867)2.11837235
85Overlapping toe (HP:0001845)2.11684798
86Atrophy/Degeneration involving motor neurons (HP:0007373)2.11219599
87Aplasia/Hypoplasia of the tibia (HP:0005772)2.11066344
88Methylmalonic acidemia (HP:0002912)2.09174530
89Parakeratosis (HP:0001036)2.08736954
90Abnormality of the hip-girdle musculature (HP:0001445)2.06916549
91Abnormality of the musculature of the pelvis (HP:0001469)2.06916549
92Patchy hypopigmentation of hair (HP:0011365)2.06564983
93Lactic acidosis (HP:0003128)2.06205300
94Neoplasm of the adrenal gland (HP:0100631)2.05274567
95Short tibia (HP:0005736)2.02449409
96Esotropia (HP:0000565)2.01339114
97Abnormal protein glycosylation (HP:0012346)2.00700219
98Abnormal glycosylation (HP:0012345)2.00700219
99Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00700219
100Abnormal protein N-linked glycosylation (HP:0012347)2.00700219
101Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.00197377
102Secondary amenorrhea (HP:0000869)1.98692367
103Neoplasm of the peripheral nervous system (HP:0100007)1.98630130
104Meningioma (HP:0002858)1.98461491
105Inability to walk (HP:0002540)1.97329461
106Pheochromocytoma (HP:0002666)1.95465004
107Medulloblastoma (HP:0002885)1.94625090
108Palpitations (HP:0001962)1.93328517
109Degeneration of the lateral corticospinal tracts (HP:0002314)1.93078117
110Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.93078117
111Aplasia/Hypoplasia of the lens (HP:0008063)1.92018908
112Poor suck (HP:0002033)1.91768861
113X-linked dominant inheritance (HP:0001423)1.90793322
114Increased muscle lipid content (HP:0009058)1.89622923
115Respiratory difficulties (HP:0002880)1.89146008
116Adrenal hypoplasia (HP:0000835)1.88781138
117Increased intramyocellular lipid droplets (HP:0012240)1.88284813
118Abnormality of the corticospinal tract (HP:0002492)1.84994198
119Long clavicles (HP:0000890)1.84403409
120Abnormal umbilical cord blood vessels (HP:0011403)1.83983310
121Single umbilical artery (HP:0001195)1.83983310
122Abnormality of the fetal cardiovascular system (HP:0010948)1.83983310
123Cerebral edema (HP:0002181)1.83008307
124Increased nuchal translucency (HP:0010880)1.82428650
125Fetal akinesia sequence (HP:0001989)1.81288690
126Posterior subcapsular cataract (HP:0007787)1.78026736
127Pelvic girdle muscle weakness (HP:0003749)1.77840440
128Glioma (HP:0009733)1.77585684
129Colon cancer (HP:0003003)1.75207059
130Aganglionic megacolon (HP:0002251)1.74954038
131Aplastic anemia (HP:0001915)1.73356526
132Muscular hypotonia of the trunk (HP:0008936)1.72479750
133Abnormality of renal resorption (HP:0011038)1.72146215
134Abnormal lung lobation (HP:0002101)1.71949688
135Redundant skin (HP:0001582)1.71644343
136Aplasia/hypoplasia of the uterus (HP:0008684)1.70181473
137CNS hypomyelination (HP:0003429)1.69599056
138Emotional lability (HP:0000712)1.69173387
139Absent epiphyses (HP:0010577)1.69030096
140Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.69030096
141Delusions (HP:0000746)1.68263340
142Hypoplasia of the capital femoral epiphysis (HP:0003090)1.66547442
143Amniotic constriction ring (HP:0009775)1.65833009
144Abnormality of placental membranes (HP:0011409)1.65833009
145Broad-based gait (HP:0002136)1.65046493
146Nephronophthisis (HP:0000090)1.64758184
147Autoamputation (HP:0001218)1.63833135
148Sensory axonal neuropathy (HP:0003390)1.63498884
149Astigmatism (HP:0000483)1.62519083
150Type I transferrin isoform profile (HP:0003642)1.62328003
151Abnormality of the septum pellucidum (HP:0007375)1.62061053
152Abnormality of cells of the erythroid lineage (HP:0012130)1.61005123
153Reticulocytopenia (HP:0001896)1.59156947
154Sclerocornea (HP:0000647)1.57802834
155Septo-optic dysplasia (HP:0100842)1.57178623
156Protruding tongue (HP:0010808)1.55726637
157Progressive inability to walk (HP:0002505)1.55256371

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.63881649
2TRIM283.23408194
3NEK13.19358845
4TNIK2.97635363
5STK162.91257806
6MAP3K122.59907831
7BUB12.55853486
8PNCK2.39929678
9MARK12.26906383
10SRPK12.12489054
11SCYL22.11397107
12MAP2K72.08459887
13TTK1.99791491
14VRK11.94771174
15CDC71.87475071
16BMPR1B1.86042207
17BRSK21.84048909
18MAPK131.83214116
19NME11.83177657
20WEE11.80462770
21MST41.79732914
22BCR1.78664388
23DYRK21.78263452
24EIF2AK11.69712525
25TSSK61.66269891
26PDK21.62491877
27CCNB11.55987478
28MAP4K21.54526233
29PLK21.54276560
30STK391.53933374
31NUAK11.51609301
32PLK31.48652235
33LIMK11.42904906
34ZAK1.40365847
35OXSR11.35939375
36TLK11.33906361
37UHMK11.32212860
38MKNK21.30859709
39MKNK11.28747666
40SIK31.28499400
41ADRBK21.28221187
42VRK21.27701740
43NTRK31.26830932
44WNK31.25818432
45BMPR21.22548014
46CDK191.21624677
47EIF2AK31.17990368
48CSNK1G31.16710936
49CLK11.14140958
50GRK71.07509390
51DYRK31.05156982
52ATR1.04895100
53CAMK2B1.04409261
54MAPKAPK51.03871221
55MINK11.01952579
56GRK51.00961176
57NEK60.98304989
58PLK40.97770778
59MAP3K40.97168213
60LATS10.92797416
61PKN10.92108789
62AURKB0.91741360
63RPS6KA40.88431702
64BRSK10.87547854
65ARAF0.85011594
66TXK0.81562242
67ATM0.80408010
68CDK80.79787587
69FES0.79273736
70MYLK0.77336263
71STK30.77183184
72NTRK20.77041047
73CSNK1G10.75512374
74NEK20.75170132
75NLK0.74174434
76KSR10.73269281
77CAMK2A0.71580917
78TESK10.71523023
79BRAF0.71239991
80CSNK1G20.71208826
81CSNK1A1L0.69961195
82AKT30.69951605
83PLK10.69182239
84MAP3K60.68807944
85DYRK1A0.68582738
86CHEK10.68386993
87YES10.67879659
88AURKA0.66403005
89NME20.65396263
90CDK140.64650181
91WNK40.64472701
92BCKDK0.63844575
93EIF2AK20.63365691
94RPS6KA50.62403781
95ACVR1B0.60736506
96CDK30.59740302
97EPHA40.59647368
98TESK20.58893038
99MUSK0.57495402
100CDK180.56350158
101IRAK30.56324227
102STK100.56073398
103PRPF4B0.55762358
104CAMK2D0.55149537
105PBK0.55138857
106PRKCE0.54564532
107ADRBK10.53741953
108PAK40.53040317
109BRD40.52778287
110STK38L0.52050549
111ROCK20.51001220
112CDK11A0.49951778
113PHKG20.49601055
114PHKG10.49601055
115CDK150.49463493
116PRKCG0.48703737
117LATS20.47140988
118TAF10.46999250
119MARK30.46988164
120DAPK10.43471682
121CSNK2A10.43115705
122CSNK1E0.42067708
123MAPK150.41850786
124RAF10.41664833
125RPS6KB20.40595415
126CAMKK20.40280674
127ERBB40.39953670
128CDK70.39449045
129ILK0.39025136
130CDK50.38736914
131ERBB30.37869969
132CHEK20.37596254
133PIM20.37087741
134FGR0.36889700
135CSNK2A20.36393007
136ALK0.36249303
137PDK30.36203945
138PDK40.36203945
139CDK10.35715276
140MAP3K50.33187121
141MOS0.33025368
142MAP2K40.32811891
143MAP3K80.30224080
144PAK10.28765156
145AKT20.28691202

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.00315668
2Proteasome_Homo sapiens_hsa030503.72563982
3RNA polymerase_Homo sapiens_hsa030203.46633556
4Protein export_Homo sapiens_hsa030603.44058723
5Parkinsons disease_Homo sapiens_hsa050123.39936313
6Ribosome_Homo sapiens_hsa030102.82625425
7Huntingtons disease_Homo sapiens_hsa050162.79510946
8Alzheimers disease_Homo sapiens_hsa050102.57027271
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.48685297
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.27780265
11Basal transcription factors_Homo sapiens_hsa030222.20886714
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.93396721
13Nicotine addiction_Homo sapiens_hsa050331.89593033
14One carbon pool by folate_Homo sapiens_hsa006701.86365602
15Spliceosome_Homo sapiens_hsa030401.77878493
16Collecting duct acid secretion_Homo sapiens_hsa049661.76759844
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.74616846
18Pyrimidine metabolism_Homo sapiens_hsa002401.64850851
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56269619
20Nucleotide excision repair_Homo sapiens_hsa034201.55580841
21RNA transport_Homo sapiens_hsa030131.52520770
22Homologous recombination_Homo sapiens_hsa034401.47470010
23Cardiac muscle contraction_Homo sapiens_hsa042601.43310098
24Vibrio cholerae infection_Homo sapiens_hsa051101.39412635
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34640695
26RNA degradation_Homo sapiens_hsa030181.34428366
27Propanoate metabolism_Homo sapiens_hsa006401.30020025
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29795968
29Synaptic vesicle cycle_Homo sapiens_hsa047211.28661163
30Serotonergic synapse_Homo sapiens_hsa047261.28177767
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26595075
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26064609
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.24906035
34Vitamin B6 metabolism_Homo sapiens_hsa007501.24873167
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.23995829
36Purine metabolism_Homo sapiens_hsa002301.23603844
37Pyruvate metabolism_Homo sapiens_hsa006201.22202814
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.15297371
39Fanconi anemia pathway_Homo sapiens_hsa034601.13980370
40Mismatch repair_Homo sapiens_hsa034301.11704297
41Carbon metabolism_Homo sapiens_hsa012001.09739081
42Phototransduction_Homo sapiens_hsa047441.07955637
43Cell cycle_Homo sapiens_hsa041101.07822698
44Non-homologous end-joining_Homo sapiens_hsa034501.05583586
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02538581
46Amphetamine addiction_Homo sapiens_hsa050311.01747972
47DNA replication_Homo sapiens_hsa030301.00773163
48Biosynthesis of amino acids_Homo sapiens_hsa012301.00050958
49Selenocompound metabolism_Homo sapiens_hsa004500.99911315
50Oocyte meiosis_Homo sapiens_hsa041140.99748773
51Rheumatoid arthritis_Homo sapiens_hsa053230.97530564
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96831105
53GABAergic synapse_Homo sapiens_hsa047270.95468295
54Folate biosynthesis_Homo sapiens_hsa007900.94823240
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93911236
56Morphine addiction_Homo sapiens_hsa050320.93313649
57Regulation of autophagy_Homo sapiens_hsa041400.92224812
58Dopaminergic synapse_Homo sapiens_hsa047280.87340769
59Ether lipid metabolism_Homo sapiens_hsa005650.86696284
60Taste transduction_Homo sapiens_hsa047420.84815643
61Epstein-Barr virus infection_Homo sapiens_hsa051690.81946934
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80913192
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78313470
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77965125
65Sphingolipid metabolism_Homo sapiens_hsa006000.76543770
66Glutamatergic synapse_Homo sapiens_hsa047240.75401919
67mRNA surveillance pathway_Homo sapiens_hsa030150.75120353
68Pentose phosphate pathway_Homo sapiens_hsa000300.74687859
69Long-term depression_Homo sapiens_hsa047300.74661285
70Circadian entrainment_Homo sapiens_hsa047130.73110026
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70179653
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69813835
73Long-term potentiation_Homo sapiens_hsa047200.69626841
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69161805
75Fatty acid elongation_Homo sapiens_hsa000620.68859728
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68582595
77Autoimmune thyroid disease_Homo sapiens_hsa053200.68278025
78Axon guidance_Homo sapiens_hsa043600.66347986
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66082191
80Shigellosis_Homo sapiens_hsa051310.65035139
81Olfactory transduction_Homo sapiens_hsa047400.63589192
82N-Glycan biosynthesis_Homo sapiens_hsa005100.62516478
83Steroid biosynthesis_Homo sapiens_hsa001000.60742877
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60731890
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59808058
86Type I diabetes mellitus_Homo sapiens_hsa049400.59692413
87Cocaine addiction_Homo sapiens_hsa050300.58333628
88Graft-versus-host disease_Homo sapiens_hsa053320.57764448
89Glutathione metabolism_Homo sapiens_hsa004800.56961111
90Allograft rejection_Homo sapiens_hsa053300.56292711
91Base excision repair_Homo sapiens_hsa034100.56165297
92Peroxisome_Homo sapiens_hsa041460.55646394
93Alcoholism_Homo sapiens_hsa050340.53652686
94Phagosome_Homo sapiens_hsa041450.53371436
95Butanoate metabolism_Homo sapiens_hsa006500.52220540
96Caffeine metabolism_Homo sapiens_hsa002320.47555995
97Renin secretion_Homo sapiens_hsa049240.45936088
98Legionellosis_Homo sapiens_hsa051340.45399209
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41437390
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40932641
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39823989
102Primary immunodeficiency_Homo sapiens_hsa053400.38740585
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38678472
104Metabolic pathways_Homo sapiens_hsa011000.38318889
105Cholinergic synapse_Homo sapiens_hsa047250.36551969
106Arachidonic acid metabolism_Homo sapiens_hsa005900.36492472
107Calcium signaling pathway_Homo sapiens_hsa040200.36330454
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35154394
109Hematopoietic cell lineage_Homo sapiens_hsa046400.34650556
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34632475
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33377248
112Oxytocin signaling pathway_Homo sapiens_hsa049210.32487612
113Viral carcinogenesis_Homo sapiens_hsa052030.32393472
114Circadian rhythm_Homo sapiens_hsa047100.29633360
115Insulin secretion_Homo sapiens_hsa049110.28190300
116p53 signaling pathway_Homo sapiens_hsa041150.27814385
117Gap junction_Homo sapiens_hsa045400.27686428
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26554079
119Fatty acid metabolism_Homo sapiens_hsa012120.25463023
120T cell receptor signaling pathway_Homo sapiens_hsa046600.25323852
121Systemic lupus erythematosus_Homo sapiens_hsa053220.24911902
122Sulfur metabolism_Homo sapiens_hsa009200.24710225
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.24074209
124Wnt signaling pathway_Homo sapiens_hsa043100.22859593
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22625305
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22189751
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21516618
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20717081
129Ras signaling pathway_Homo sapiens_hsa040140.19659043
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.19470788
131Salmonella infection_Homo sapiens_hsa051320.19377823
132Asthma_Homo sapiens_hsa053100.18485455
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.18239483
134Melanogenesis_Homo sapiens_hsa049160.17885578
135Thyroid cancer_Homo sapiens_hsa052160.16567020
136TGF-beta signaling pathway_Homo sapiens_hsa043500.16525931
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.16065924
138Salivary secretion_Homo sapiens_hsa049700.15371806
139Hepatitis B_Homo sapiens_hsa051610.13108735
140Herpes simplex infection_Homo sapiens_hsa051680.10891313
141Measles_Homo sapiens_hsa051620.09983140
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.05983940
143Primary bile acid biosynthesis_Homo sapiens_hsa001200.04172823
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.03828114
145Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.02874898
146Colorectal cancer_Homo sapiens_hsa052100.01406419

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »