TIRAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.29726259
2L-phenylalanine catabolic process (GO:0006559)5.29726259
3indole-containing compound catabolic process (GO:0042436)5.14236743
4indolalkylamine catabolic process (GO:0046218)5.14236743
5tryptophan catabolic process (GO:0006569)5.14236743
6aromatic amino acid family catabolic process (GO:0009074)5.14142026
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.00375593
8L-phenylalanine metabolic process (GO:0006558)5.00375593
9behavioral response to nicotine (GO:0035095)4.89132511
10tryptophan metabolic process (GO:0006568)4.77532479
11kynurenine metabolic process (GO:0070189)4.57508586
12protein carboxylation (GO:0018214)4.43353178
13peptidyl-glutamic acid carboxylation (GO:0017187)4.43353178
14L-fucose catabolic process (GO:0042355)4.42589603
15fucose catabolic process (GO:0019317)4.42589603
16L-fucose metabolic process (GO:0042354)4.42589603
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.38556111
18urea cycle (GO:0000050)4.32373619
19urea metabolic process (GO:0019627)4.32373619
20activated T cell proliferation (GO:0050798)4.09450848
21amine catabolic process (GO:0009310)4.08205392
22cellular biogenic amine catabolic process (GO:0042402)4.08205392
23regulation of fibrinolysis (GO:0051917)4.06868763
24bile acid biosynthetic process (GO:0006699)4.04735225
25negative regulation of fibrinolysis (GO:0051918)4.01748489
26nitrogen cycle metabolic process (GO:0071941)4.01448626
27high-density lipoprotein particle remodeling (GO:0034375)3.99572725
28regulation of protein activation cascade (GO:2000257)3.94505073
29DNA deamination (GO:0045006)3.93895078
30complement activation, alternative pathway (GO:0006957)3.90305713
31glyoxylate metabolic process (GO:0046487)3.82848626
32cellular glucuronidation (GO:0052695)3.79328345
33killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.71884296
34disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.71884296
35regulation of complement activation (GO:0030449)3.64170805
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.58348524
37positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.57691582
38sulfur amino acid catabolic process (GO:0000098)3.56483307
39glucuronate metabolic process (GO:0019585)3.56320982
40uronic acid metabolic process (GO:0006063)3.56320982
41aromatic amino acid family metabolic process (GO:0009072)3.55933736
42indolalkylamine metabolic process (GO:0006586)3.54792919
43aldehyde catabolic process (GO:0046185)3.51798098
44positive regulation of triglyceride lipase activity (GO:0061365)3.50622299
45positive regulation of lipoprotein lipase activity (GO:0051006)3.50622299
46cell wall macromolecule metabolic process (GO:0044036)3.49827341
47omega-hydroxylase P450 pathway (GO:0097267)3.49093049
48regulation of triglyceride catabolic process (GO:0010896)3.48705281
49regulation of cholesterol esterification (GO:0010872)3.48567359
50macromolecular complex remodeling (GO:0034367)3.46819313
51plasma lipoprotein particle remodeling (GO:0034369)3.46819313
52protein-lipid complex remodeling (GO:0034368)3.46819313
53fibrinolysis (GO:0042730)3.43799716
54reverse cholesterol transport (GO:0043691)3.43322511
55bile acid metabolic process (GO:0008206)3.42347489
56NAD biosynthetic process (GO:0009435)3.42108202
57phospholipid efflux (GO:0033700)3.41108729
58bile acid and bile salt transport (GO:0015721)3.38271582
59plasma lipoprotein particle clearance (GO:0034381)3.35030536
60imidazole-containing compound metabolic process (GO:0052803)3.32504089
61arginine metabolic process (GO:0006525)3.31329018
62disruption of cells of other organism (GO:0044364)3.29937643
63killing of cells of other organism (GO:0031640)3.29937643
64opsonization (GO:0008228)3.29833329
65serine family amino acid catabolic process (GO:0009071)3.28831122
66pyridine nucleotide biosynthetic process (GO:0019363)3.28155744
67nicotinamide nucleotide biosynthetic process (GO:0019359)3.28155744
68alpha-linolenic acid metabolic process (GO:0036109)3.27879733
69acylglycerol homeostasis (GO:0055090)3.24432117
70triglyceride homeostasis (GO:0070328)3.24432117
71low-density lipoprotein particle remodeling (GO:0034374)3.24219497
72homocysteine metabolic process (GO:0050667)3.24009932
73neural tube formation (GO:0001841)3.20893152
74blood coagulation, intrinsic pathway (GO:0007597)3.17788547
75cysteine metabolic process (GO:0006534)3.15821489
76very-low-density lipoprotein particle assembly (GO:0034379)3.13754727
77plasma lipoprotein particle assembly (GO:0034377)3.12986158
78protein activation cascade (GO:0072376)3.12527653
79cholesterol efflux (GO:0033344)3.11277873
80positive regulation of defense response to virus by host (GO:0002230)3.11077136
81alpha-amino acid catabolic process (GO:1901606)3.09661894
82protein neddylation (GO:0045116)3.07201605
83amino-acid betaine metabolic process (GO:0006577)3.04809267
84acute-phase response (GO:0006953)3.04791649
85tyrosine metabolic process (GO:0006570)3.04487437
86leukocyte migration involved in inflammatory response (GO:0002523)3.03149686
87purinergic nucleotide receptor signaling pathway (GO:0035590)3.01270373
88benzene-containing compound metabolic process (GO:0042537)2.97547424
89complement activation, classical pathway (GO:0006958)2.97312896
90dopamine transport (GO:0015872)2.97231995
91negative regulation of lipase activity (GO:0060192)2.95013652
92neutrophil activation involved in immune response (GO:0002283)2.92615458
93glycine metabolic process (GO:0006544)2.92075030
94positive regulation of coagulation (GO:0050820)2.91532183
95complement activation (GO:0006956)2.90932162
96coenzyme catabolic process (GO:0009109)2.90670141
97plasma lipoprotein particle organization (GO:0071827)2.89061332
98ethanol oxidation (GO:0006069)2.88408440
99phospholipid homeostasis (GO:0055091)2.87918831
100positive regulation of hemostasis (GO:1900048)2.85685252
101positive regulation of blood coagulation (GO:0030194)2.85685252
102epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.85107252
103cofactor catabolic process (GO:0051187)2.84535669
104N-acetylneuraminate metabolic process (GO:0006054)2.82654739
105cellular response to exogenous dsRNA (GO:0071360)2.81729759
106regulation of action potential (GO:0098900)2.80321232
107detection of light stimulus involved in sensory perception (GO:0050962)2.80162945
108detection of light stimulus involved in visual perception (GO:0050908)2.80162945
109serine family amino acid biosynthetic process (GO:0009070)2.80019129
110negative regulation of hemostasis (GO:1900047)2.79676746
111negative regulation of blood coagulation (GO:0030195)2.79676746
112cellular amino acid catabolic process (GO:0009063)2.77599328
113protein-lipid complex assembly (GO:0065005)2.77299507
114preassembly of GPI anchor in ER membrane (GO:0016254)2.76714010
115water-soluble vitamin biosynthetic process (GO:0042364)2.76459811
116cell wall macromolecule catabolic process (GO:0016998)2.74943587
117regulation of B cell receptor signaling pathway (GO:0050855)2.73861139
118negative regulation of cholesterol transport (GO:0032375)2.72709674
119negative regulation of sterol transport (GO:0032372)2.72709674
120negative regulation of mast cell activation (GO:0033004)2.72568152
121serine family amino acid metabolic process (GO:0009069)2.71558434
122protein-lipid complex subunit organization (GO:0071825)2.69883588
123regulation of mast cell activation (GO:0033003)2.69530777
124mast cell degranulation (GO:0043303)2.69079024
125mast cell activation involved in immune response (GO:0002279)2.69079024
126cholesterol homeostasis (GO:0042632)2.68852405
127tolerance induction (GO:0002507)2.67985183
128response to peptidoglycan (GO:0032494)2.67201893
129neutrophil activation (GO:0042119)2.64978804
130basic amino acid transport (GO:0015802)2.64733547
131multicellular organism reproduction (GO:0032504)2.64379038
132cellular ketone body metabolic process (GO:0046950)2.63773725
133mast cell activation (GO:0045576)2.63278831
134positive regulation of T cell mediated cytotoxicity (GO:0001916)2.62948753
135interferon-gamma production (GO:0032609)2.59611278
136opioid receptor signaling pathway (GO:0038003)2.59398294
137exogenous drug catabolic process (GO:0042738)2.58542785
138regulation of memory T cell differentiation (GO:0043380)2.57313035
139regulation of T cell mediated cytotoxicity (GO:0001914)2.57111006
140negative regulation of interleukin-1 production (GO:0032692)2.55658732
141N-acetylglucosamine metabolic process (GO:0006044)2.55446247
142negative regulation of cell killing (GO:0031342)2.52466603
143negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.52466603
144fucosylation (GO:0036065)2.51986128
145piRNA metabolic process (GO:0034587)2.51062780
146adaptation of signaling pathway (GO:0023058)2.48472400
147histamine transport (GO:0051608)2.47886049
148platelet dense granule organization (GO:0060155)2.47401800
149pantothenate metabolic process (GO:0015939)2.44999073
150cilium or flagellum-dependent cell motility (GO:0001539)2.44404724
151macroautophagy (GO:0016236)2.43336946
152T cell proliferation (GO:0042098)2.42440410
153cornea development in camera-type eye (GO:0061303)2.41685733
154drug catabolic process (GO:0042737)2.41211031
155positive regulation of mast cell activation (GO:0033005)2.39959301
156negative regulation of protein autophosphorylation (GO:0031953)2.39667893
157S-adenosylmethionine metabolic process (GO:0046500)2.38996221
158phosphatidylinositol acyl-chain remodeling (GO:0036149)2.38661843
159hepatocyte apoptotic process (GO:0097284)2.38180136
160polyol catabolic process (GO:0046174)2.37812620
161DNA methylation involved in gamete generation (GO:0043046)2.37332089
162negative regulation of T cell mediated immunity (GO:0002710)2.37165827
163indole-containing compound metabolic process (GO:0042430)2.36319074
164mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.35764483
165mitochondrial respiratory chain complex I assembly (GO:0032981)2.35764483
166NADH dehydrogenase complex assembly (GO:0010257)2.35764483
167neuronal action potential (GO:0019228)2.31207994
168sulfation (GO:0051923)2.28042753
169epithelial cilium movement (GO:0003351)2.27753936
170ketone body metabolic process (GO:1902224)2.26888730
171keratinocyte development (GO:0003334)2.26003099
172leukocyte degranulation (GO:0043299)2.25746994
173rRNA catabolic process (GO:0016075)2.24369428
174RNA destabilization (GO:0050779)2.24327938
175negative regulation of cAMP-mediated signaling (GO:0043951)2.24257408
176negative regulation of translation, ncRNA-mediated (GO:0040033)2.23677166
177regulation of translation, ncRNA-mediated (GO:0045974)2.23677166
178negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.23677166
179protein complex biogenesis (GO:0070271)2.23497346
180regulation of hippo signaling (GO:0035330)2.23303071
181snRNA transcription (GO:0009301)2.23176613
182lysosome localization (GO:0032418)2.22803265
183positive regulation of interleukin-1 beta secretion (GO:0050718)2.22720365
184parturition (GO:0007567)2.22150098
185regulation of cilium movement (GO:0003352)2.21213242
186cytidine metabolic process (GO:0046087)2.20883709
187cytidine catabolic process (GO:0006216)2.20883709
188cytidine deamination (GO:0009972)2.20883709
189oxidative demethylation (GO:0070989)2.18108528

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.47522409
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.00700014
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.34932749
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.61618794
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.20585041
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.19894253
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.78522681
8ZNF274_21170338_ChIP-Seq_K562_Hela3.62292800
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.26016304
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.24819233
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.16477214
12BP1_19119308_ChIP-ChIP_Hs578T_Human3.03095299
13IGF1R_20145208_ChIP-Seq_DFB_Human2.72859867
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.58477264
15GBX2_23144817_ChIP-Seq_PC3_Human2.58061688
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.56512808
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.55198739
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.43480260
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.40712635
20VDR_22108803_ChIP-Seq_LS180_Human2.28328106
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21000852
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.20637156
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.19582774
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13902976
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.07906286
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.07884582
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.07730613
28EZH2_22144423_ChIP-Seq_EOC_Human1.99746836
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94307882
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92947535
31ER_23166858_ChIP-Seq_MCF-7_Human1.90417773
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.87342418
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81756870
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.79750713
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73687302
36GATA3_21878914_ChIP-Seq_MCF-7_Human1.69148095
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.67720297
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.66515794
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65740096
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63311554
41GATA3_26560356_Chip-Seq_TH2_Human1.52164128
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50196735
43ETV2_25802403_ChIP-Seq_MESCs_Mouse1.49546167
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46894701
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45579337
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43680088
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41109555
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40653467
49TP53_22573176_ChIP-Seq_HFKS_Human1.39562391
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39494753
51NANOG_20526341_ChIP-Seq_ESCs_Human1.37879981
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33848073
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32470571
54ERA_21632823_ChIP-Seq_H3396_Human1.32302783
55BCAT_22108803_ChIP-Seq_LS180_Human1.30072089
56EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.29043582
57EWS_26573619_Chip-Seq_HEK293_Human1.28961138
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25047434
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24493594
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23205960
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22514863
62SOX2_19829295_ChIP-Seq_ESCs_Human1.21156100
63NANOG_19829295_ChIP-Seq_ESCs_Human1.21156100
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20664535
65P300_19829295_ChIP-Seq_ESCs_Human1.19138222
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17689879
67CBP_20019798_ChIP-Seq_JUKART_Human1.17689879
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.17526547
69SCL_19346495_ChIP-Seq_HPC-7_Human1.17336260
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17210890
71TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.16431070
72PU_27001747_Chip-Seq_BMDM_Mouse1.16335959
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15930022
74GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.15909185
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.15444593
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15444593
77HOXB7_26014856_ChIP-Seq_BT474_Human1.14996719
78* SPI1_23547873_ChIP-Seq_NB4_Human1.14880663
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14212908
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13814887
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13392969
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13251907
83SMRT_27268052_Chip-Seq_Bcells_Human1.13096486
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12665121
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12665121
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.12472287
87MYC_19829295_ChIP-Seq_ESCs_Human1.11820229
88NCOR_22424771_ChIP-Seq_293T_Human1.11791251
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11456212
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09636230
91FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09615889
92AR_25329375_ChIP-Seq_VCAP_Human1.09213901
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.09068239
94RUNX_20019798_ChIP-Seq_JUKART_Human1.08738734
95TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08229991
96VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07787322
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07396504
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06759815
99GATA2_21666600_ChIP-Seq_HMVEC_Human1.06301634
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06086784
101OCT4_20526341_ChIP-Seq_ESCs_Human1.05330214
102NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05177740
103NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05177740
104SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04910452
105GATA3_27048872_Chip-Seq_THYMUS_Human1.04680134
106GATA4_25053715_ChIP-Seq_YYC3_Human1.04635483
107STAT3_23295773_ChIP-Seq_U87_Human1.03872688
108HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03268799
109IRF1_19129219_ChIP-ChIP_H3396_Human1.03057416
110STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03019156
111RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02468439
112FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01946176
113TAF2_19829295_ChIP-Seq_ESCs_Human1.01879435
114CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01854642
115PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01707616
116IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01294140
117TCF4_23295773_ChIP-Seq_U87_Human1.00621674
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00319579
119EZH2_27294783_Chip-Seq_NPCs_Mouse0.99047243
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98546166
121RAC3_21632823_ChIP-Seq_H3396_Human0.98378865
122MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97364292
123STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.97077988
124FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96989379
125MYB_26560356_Chip-Seq_TH2_Human0.96866810
126CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96865922
127OCT1_27270436_Chip-Seq_PROSTATE_Human0.96466134
128TAF15_26573619_Chip-Seq_HEK293_Human0.96161050
129TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.94833274
130* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94720309
131PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94339263
132CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93188365
133SOX2_20726797_ChIP-Seq_SW620_Human0.92836219
134TDRD3_21172665_ChIP-Seq_MCF-7_Human0.92530155
135TCF4_22108803_ChIP-Seq_LS180_Human0.92456090
136PIAS1_25552417_ChIP-Seq_VCAP_Human0.92428285
137FOXH1_21741376_ChIP-Seq_EPCs_Human0.92336357
138FOXH1_21741376_ChIP-Seq_ESCs_Human0.92195296
139GATA1_22025678_ChIP-Seq_K562_Human0.91222452
140PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91059841
141P53_21459846_ChIP-Seq_SAOS-2_Human0.90961639
142E2F1_20622854_ChIP-Seq_HELA_Human0.90706048
143LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88844822
144GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87819334
145GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87132103
146HNF4A_19822575_ChIP-Seq_HepG2_Human0.86772838
147PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86401441
148* RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86302766
149SOX2_27498859_Chip-Seq_STOMACH_Mouse0.85876713
150PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.85782632
151SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83938276
152PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83381580
153TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83176613
154FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82437548
155ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82160430
156HTT_18923047_ChIP-ChIP_STHdh_Human0.81745428
157AR_20517297_ChIP-Seq_VCAP_Human0.81566447
158* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80682704
159ERG_20887958_ChIP-Seq_HPC-7_Mouse0.79288034
160VDR_24787735_ChIP-Seq_THP-1_Human0.79232170
161MYB_26560356_Chip-Seq_TH1_Human0.79175363
162CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78344424
163FLI1_27457419_Chip-Seq_LIVER_Mouse0.77978454
164FOXA2_19822575_ChIP-Seq_HepG2_Human0.77810279
165E2F7_22180533_ChIP-Seq_HELA_Human0.76411655
166SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.76248970
167SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.76248970
168RUNX1_27457419_Chip-Seq_LIVER_Mouse0.76246834
169KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.74932805
170WT1_19549856_ChIP-ChIP_CCG9911_Human0.74828806
171SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.73470081
172KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72626702
173RUNX1_22412390_ChIP-Seq_EML_Mouse0.72509860
174CDX2_20551321_ChIP-Seq_CACO-2_Human0.72430732
175CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.72310980

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.64807657
2MP0005360_urolithiasis4.87839801
3MP0005085_abnormal_gallbladder_physiolo4.35761572
4MP0005365_abnormal_bile_salt3.94948944
5MP0008875_abnormal_xenobiotic_pharmacok3.32038135
6MP0003806_abnormal_nucleotide_metabolis3.01010142
7MP0003252_abnormal_bile_duct2.70750590
8MP0003787_abnormal_imprinting2.45918772
9MP0005083_abnormal_biliary_tract2.38943160
10MP0009840_abnormal_foam_cell2.37878746
11MP0003724_increased_susceptibility_to2.12944383
12MP0009697_abnormal_copulation2.10296062
13MP0010329_abnormal_lipoprotein_level2.09819017
14MP0008877_abnormal_DNA_methylation2.07283989
15MP0001666_abnormal_nutrient_absorption1.93752914
16MP0003436_decreased_susceptibility_to1.92360682
17MP0002138_abnormal_hepatobiliary_system1.92022786
18MP0001919_abnormal_reproductive_system1.89782655
19MP0003191_abnormal_cellular_cholesterol1.84631588
20MP0005551_abnormal_eye_electrophysiolog1.83589837
21* MP0001835_abnormal_antigen_presentation1.83083069
22MP0002837_dystrophic_cardiac_calcinosis1.81414485
23MP0000569_abnormal_digit_pigmentation1.81219985
24MP0001986_abnormal_taste_sensitivity1.80574217
25MP0009764_decreased_sensitivity_to1.79740781
26MP0009785_altered_susceptibility_to1.79126181
27MP0001968_abnormal_touch/_nociception1.76105620
28MP0003195_calcinosis1.74400502
29MP0008872_abnormal_physiological_respon1.73005897
30MP0008004_abnormal_stomach_pH1.71288757
31MP0005332_abnormal_amino_acid1.62846969
32MP0000427_abnormal_hair_cycle1.61636927
33* MP0002419_abnormal_innate_immunity1.61466065
34MP0003011_delayed_dark_adaptation1.61091835
35MP0003186_abnormal_redox_activity1.60860693
36MP0005646_abnormal_pituitary_gland1.57816124
37MP0005084_abnormal_gallbladder_morpholo1.57696098
38MP0004381_abnormal_hair_follicle1.57050445
39MP0005167_abnormal_blood-brain_barrier1.53384816
40MP0000566_synostosis1.52851340
41MP0002693_abnormal_pancreas_physiology1.51787442
42MP0004043_abnormal_pH_regulation1.50567342
43MP0005408_hypopigmentation1.48264479
44MP0002102_abnormal_ear_morphology1.47653752
45MP0000609_abnormal_liver_physiology1.47385216
46MP0004142_abnormal_muscle_tone1.44220454
47MP0005464_abnormal_platelet_physiology1.43578105
48MP0003172_abnormal_lysosome_physiology1.42377968
49MP0001853_heart_inflammation1.40418315
50* MP0005025_abnormal_response_to1.39379390
51MP0002736_abnormal_nociception_after1.38603105
52MP0010368_abnormal_lymphatic_system1.38179017
53MP0001764_abnormal_homeostasis1.37165568
54MP0003868_abnormal_feces_composition1.35595175
55MP0004019_abnormal_vitamin_homeostasis1.32663818
56MP0005410_abnormal_fertilization1.32554539
57MP0009379_abnormal_foot_pigmentation1.31698825
58MP0006082_CNS_inflammation1.31207936
59MP0002148_abnormal_hypersensitivity_rea1.28730955
60MP0005451_abnormal_body_composition1.28256628
61MP0003646_muscle_fatigue1.28140861
62MP0008469_abnormal_protein_level1.27850659
63MP0003656_abnormal_erythrocyte_physiolo1.26339113
64MP0000230_abnormal_systemic_arterial1.25598943
65MP0005389_reproductive_system_phenotype1.25112693
66MP0002118_abnormal_lipid_homeostasis1.19767462
67MP0005319_abnormal_enzyme/_coenzyme1.19684123
68MP0001790_abnormal_immune_system1.19603788
69MP0005387_immune_system_phenotype1.19603788
70MP0006036_abnormal_mitochondrial_physio1.16012981
71MP0002132_abnormal_respiratory_system1.15606274
72MP0005645_abnormal_hypothalamus_physiol1.14985343
73MP0005253_abnormal_eye_physiology1.13901391
74MP0005075_abnormal_melanosome_morpholog1.12220413
75MP0001529_abnormal_vocalization1.09431639
76* MP0009763_increased_sensitivity_to1.08769484
77MP0005310_abnormal_salivary_gland1.08738099
78MP0006072_abnormal_retinal_apoptosis1.08087700
79* MP0001800_abnormal_humoral_immune1.07751781
80MP0006035_abnormal_mitochondrial_morpho1.05413271
81* MP0002452_abnormal_antigen_presenting1.05407165
82MP0005000_abnormal_immune_tolerance1.03701501
83MP0001845_abnormal_inflammatory_respons1.03096051
84MP0000470_abnormal_stomach_morphology1.03071463
85MP0000598_abnormal_liver_morphology1.01672841
86MP0001533_abnormal_skeleton_physiology1.00351561
87MP0005584_abnormal_enzyme/coenzyme_acti0.97944653
88MP0000465_gastrointestinal_hemorrhage0.97312931
89MP0000685_abnormal_immune_system0.96824582
90MP0001905_abnormal_dopamine_level0.96642956
91MP0005409_darkened_coat_color0.95551541
92MP0004484_altered_response_of0.95337511
93* MP0002723_abnormal_immune_serum0.94285305
94MP0004782_abnormal_surfactant_physiolog0.94234719
95MP0003303_peritoneal_inflammation0.92199033
96MP0009046_muscle_twitch0.92091160
97MP0002928_abnormal_bile_duct0.91458587
98MP0002733_abnormal_thermal_nociception0.91350746
99MP0001970_abnormal_pain_threshold0.90673735
100MP0003763_abnormal_thymus_physiology0.89596976
101MP0001765_abnormal_ion_homeostasis0.89310401
102* MP0002398_abnormal_bone_marrow0.88665991
103MP0000015_abnormal_ear_pigmentation0.88347677
104MP0001756_abnormal_urination0.88109789
105MP0001873_stomach_inflammation0.86415541
106MP0002396_abnormal_hematopoietic_system0.86287104
107MP0005647_abnormal_sex_gland0.85320959
108MP0000343_altered_response_to0.85083750
109MP0004130_abnormal_muscle_cell0.85032490
110MP0002078_abnormal_glucose_homeostasis0.83459171
111MP0000858_altered_metastatic_potential0.83064225
112MP0010155_abnormal_intestine_physiology0.83012519
113MP0003638_abnormal_response/metabolism_0.82955228
114MP0005448_abnormal_energy_balance0.82008341
115MP0001944_abnormal_pancreas_morphology0.81913285
116MP0005248_abnormal_Harderian_gland0.81033265
117* MP0001819_abnormal_immune_cell0.80517337
118MP0009745_abnormal_behavioral_response0.79717153
119MP0002277_abnormal_respiratory_mucosa0.79698284
120MP0005164_abnormal_response_to0.79522197
121MP0005671_abnormal_response_to0.79131515
122* MP0002420_abnormal_adaptive_immunity0.78808910
123MP0003045_fibrosis0.77893883
124* MP0002429_abnormal_blood_cell0.77663648
125MP0002160_abnormal_reproductive_system0.77510941
126MP0002722_abnormal_immune_system0.76099066
127MP0009643_abnormal_urine_homeostasis0.73206475
128MP0002166_altered_tumor_susceptibility0.73121435
129MP0005023_abnormal_wound_healing0.71728401
130MP0003136_yellow_coat_color0.71143444
131MP0002933_joint_inflammation0.69839542
132MP0004883_abnormal_blood_vessel0.69305622
133MP0002405_respiratory_system_inflammati0.68890441
134MP0002876_abnormal_thyroid_physiology0.67375385
135MP0000249_abnormal_blood_vessel0.66958272
136MP0005174_abnormal_tail_pigmentation0.66507213
137MP0003718_maternal_effect0.66221825
138MP0005670_abnormal_white_adipose0.66114881
139MP0003279_aneurysm0.65560380
140MP0009642_abnormal_blood_homeostasis0.64929574
141MP0005058_abnormal_lysosome_morphology0.64814524
142MP0003943_abnormal_hepatobiliary_system0.64463275
143MP0009053_abnormal_anal_canal0.64380636
144MP0005376_homeostasis/metabolism_phenot0.64204838
145MP0000767_abnormal_smooth_muscle0.63211571
146MP0003828_pulmonary_edema0.63191044
147* MP0000716_abnormal_immune_system0.60474828
148MP0009384_cardiac_valve_regurgitation0.60394855
149MP0006292_abnormal_olfactory_placode0.60306359
150MP0000689_abnormal_spleen_morphology0.60102369
151MP0000490_abnormal_crypts_of0.58824252

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)5.67886462
2Deep venous thrombosis (HP:0002625)5.11656092
3Joint hemorrhage (HP:0005261)5.07657181
4Intrahepatic cholestasis (HP:0001406)4.97429817
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.97154808
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.79501516
7Recurrent gram-negative bacterial infections (HP:0005420)4.30172983
8Xanthomatosis (HP:0000991)4.19567049
9Hypobetalipoproteinemia (HP:0003563)4.18937683
10Complement deficiency (HP:0004431)3.99417617
11Abnormality of the common coagulation pathway (HP:0010990)3.91112554
12Congenital stationary night blindness (HP:0007642)3.90365391
13Abnormality of pyrimidine metabolism (HP:0004353)3.77345312
14Stomatitis (HP:0010280)3.66894016
15Hyperlipoproteinemia (HP:0010980)3.63109256
16Conjugated hyperbilirubinemia (HP:0002908)3.40121879
17Pancreatic cysts (HP:0001737)3.37616123
18Systemic lupus erythematosus (HP:0002725)3.36938858
19Reduced antithrombin III activity (HP:0001976)3.32632974
20Fat malabsorption (HP:0002630)3.30040533
21Abnormality of the intrinsic pathway (HP:0010989)3.25873424
22Abnormality of complement system (HP:0005339)3.24025046
23Epidermoid cyst (HP:0200040)3.22374452
24Eczematoid dermatitis (HP:0000976)3.20994971
25Abnormal drinking behavior (HP:0030082)3.20150168
26Polydipsia (HP:0001959)3.20150168
27Myocardial infarction (HP:0001658)3.20034840
28Hypolipoproteinemia (HP:0010981)3.13249860
29Abnormality of midbrain morphology (HP:0002418)3.11953377
30Molar tooth sign on MRI (HP:0002419)3.11953377
31Hyperglycinemia (HP:0002154)3.11483975
32Abnormality of glutamine family amino acid metabolism (HP:0010902)3.10500372
33Nephronophthisis (HP:0000090)3.08616377
34Abnormality of methionine metabolism (HP:0010901)3.05156550
35Recurrent bacterial skin infections (HP:0005406)3.04901553
36Recurrent abscess formation (HP:0002722)3.02659086
37Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.02426927
38Pancreatic fibrosis (HP:0100732)2.97671114
39Chronic hepatic failure (HP:0100626)2.97133932
40Gingival bleeding (HP:0000225)2.95151286
41Abnormality of the renal cortex (HP:0011035)2.94283770
42Steatorrhea (HP:0002570)2.86499240
43Hyperammonemia (HP:0001987)2.82626678
44Abnormality of aspartate family amino acid metabolism (HP:0010899)2.79648493
45Abnormality of sulfur amino acid metabolism (HP:0004339)2.78590818
46Abnormality of the renal medulla (HP:0100957)2.78470020
47Hypoalphalipoproteinemia (HP:0003233)2.72367537
48Glomerulonephritis (HP:0000099)2.64871452
49True hermaphroditism (HP:0010459)2.63351708
50Elevated erythrocyte sedimentation rate (HP:0003565)2.60276169
51Menorrhagia (HP:0000132)2.59739403
52Clumsiness (HP:0002312)2.59730887
53Hypoglycemic coma (HP:0001325)2.58297427
54Progressive cerebellar ataxia (HP:0002073)2.58219591
55Hypercholesterolemia (HP:0003124)2.56904738
56Attenuation of retinal blood vessels (HP:0007843)2.54214507
57Abolished electroretinogram (ERG) (HP:0000550)2.52431757
58Type II lissencephaly (HP:0007260)2.51003359
59Hypothermia (HP:0002045)2.50872602
60Abnormal rod and cone electroretinograms (HP:0008323)2.47444874
61Tubular atrophy (HP:0000092)2.44258880
62Hyperventilation (HP:0002883)2.44248584
63Vacuolated lymphocytes (HP:0001922)2.44226870
64Inability to walk (HP:0002540)2.42066574
65Abnormality of nucleobase metabolism (HP:0010932)2.41972871
66Abnormality of glycine metabolism (HP:0010895)2.41714388
67Abnormality of serine family amino acid metabolism (HP:0010894)2.41714388
68Abnormality of fatty-acid metabolism (HP:0004359)2.40864632
69Ketoacidosis (HP:0001993)2.40108320
70Large for gestational age (HP:0001520)2.39600264
71Abnormality of serum amino acid levels (HP:0003112)2.38879386
72Absent rod-and cone-mediated responses on ERG (HP:0007688)2.34734819
73Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.34377983
74Increased neuronal autofluorescent lipopigment (HP:0002074)2.33754463
75Polyuria (HP:0000103)2.33438483
76Hepatocellular carcinoma (HP:0001402)2.32930025
77Recurrent skin infections (HP:0001581)2.32158011
78Hyperbilirubinemia (HP:0002904)2.31814691
79Vascular calcification (HP:0004934)2.31742255
80Optic neuritis (HP:0100653)2.31208002
81Retrobulbar optic neuritis (HP:0100654)2.31208002
82Progressive inability to walk (HP:0002505)2.30990121
83Lipid accumulation in hepatocytes (HP:0006561)2.29565225
84Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.28525325
85Hyperglycinuria (HP:0003108)2.25962120
86Abnormality of iron homeostasis (HP:0011031)2.24916339
87Opisthotonus (HP:0002179)2.22074014
88Bile duct proliferation (HP:0001408)2.20874597
89Abnormal biliary tract physiology (HP:0012439)2.20874597
90Thrombophlebitis (HP:0004418)2.17652121
91Renal cortical cysts (HP:0000803)2.17535242
92Epistaxis (HP:0000421)2.16851346
93Abnormality of macrophages (HP:0004311)2.14955776
94Pulmonary embolism (HP:0002204)2.13725799
95Renal Fanconi syndrome (HP:0001994)2.13534393
96Chronic obstructive pulmonary disease (HP:0006510)2.12941682
97Obstructive lung disease (HP:0006536)2.12941682
98Spontaneous abortion (HP:0005268)2.12873362
99Increased serum ferritin (HP:0003281)2.12232822
100Chromosomal breakage induced by crosslinking agents (HP:0003221)2.09360566
101Nephritis (HP:0000123)2.07446329
102Abnormal delayed hypersensitivity skin test (HP:0002963)2.07330792
103Amyloidosis (HP:0011034)2.06439958
104Cardiovascular calcification (HP:0011915)2.04410570
105Abnormality of the prostate (HP:0008775)2.04211507
106Ketosis (HP:0001946)2.03993432
107Absent/shortened dynein arms (HP:0200106)2.02928955
108Dynein arm defect of respiratory motile cilia (HP:0012255)2.02928955
109Lissencephaly (HP:0001339)2.02532937
110Cystic liver disease (HP:0006706)2.01653074
111Dry hair (HP:0011359)2.01610319
112Abnormality of transition element cation homeostasis (HP:0011030)2.01476030
113Pancreatitis (HP:0001733)2.01185061
114Chromsome breakage (HP:0040012)2.00684169
115Disproportionate short-trunk short stature (HP:0003521)1.97803800
116Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96740358
117Dicarboxylic aciduria (HP:0003215)1.96740358
118Tetany (HP:0001281)1.95596863
119Gaze-evoked nystagmus (HP:0000640)1.95537785
120Exertional dyspnea (HP:0002875)1.95396056
121Elevated hepatic transaminases (HP:0002910)1.94950798
122Encephalitis (HP:0002383)1.94078969
123Decreased central vision (HP:0007663)1.93830913
124Hypochromic microcytic anemia (HP:0004840)1.93040827
125Mediastinal lymphadenopathy (HP:0100721)1.92734252
126Episodic fever (HP:0001954)1.92593764
127Purpura (HP:0000979)1.92278666
128Esophageal varix (HP:0002040)1.90291134
129Periodontitis (HP:0000704)1.89565518
130Abnormal urine output (HP:0012590)1.89565413
131Increased hepatocellular lipid droplets (HP:0006565)1.88792659
132Meningitis (HP:0001287)1.87756716
133Pendular nystagmus (HP:0012043)1.87624490
134Bony spicule pigmentary retinopathy (HP:0007737)1.87011256
135Hypomagnesemia (HP:0002917)1.86610149
136Urticaria (HP:0001025)1.85971738
137Congenital hepatic fibrosis (HP:0002612)1.85829909
138Bulbous nose (HP:0000414)1.85424186
139Abnormal platelet volume (HP:0011876)1.85323970
140Prolonged bleeding time (HP:0003010)1.85242275
141Severe muscular hypotonia (HP:0006829)1.85173341
142Glycosuria (HP:0003076)1.85035192
143Abnormality of urine glucose concentration (HP:0011016)1.85035192
144Type I transferrin isoform profile (HP:0003642)1.84597543
145Recurrent fungal infections (HP:0002841)1.84019844
146Sclerocornea (HP:0000647)1.83489459
147Petechiae (HP:0000967)1.83123136
148Lower limb hyperreflexia (HP:0002395)1.82815738
149Nausea (HP:0002018)1.82616428
150Decreased circulating renin level (HP:0003351)1.82599510
151Constricted visual fields (HP:0001133)1.82457591
152Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81632707
153Abnormality of alanine metabolism (HP:0010916)1.81302535
154Hyperalaninemia (HP:0003348)1.81302535
155Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81302535
156Mitochondrial inheritance (HP:0001427)1.80965048
157Gastrointestinal infarctions (HP:0005244)1.80848498
158Hypochromic anemia (HP:0001931)1.80698311
1593-Methylglutaconic aciduria (HP:0003535)1.80128276
160Tinnitus (HP:0000360)1.79978754
161Abnormal ciliary motility (HP:0012262)1.79784984
162Orchitis (HP:0100796)1.79507585
163Gingivitis (HP:0000230)1.78418986
164Abnormal respiratory epithelium morphology (HP:0012253)1.78192707
165Abnormal respiratory motile cilium morphology (HP:0005938)1.78192707
166Increased CSF lactate (HP:0002490)1.77748467
167Increased cerebral lipofuscin (HP:0011813)1.75099568
168Furrowed tongue (HP:0000221)1.74764159
169Abnormality of purine metabolism (HP:0004352)1.74286650
170Microcytic anemia (HP:0001935)1.74170919
171Generalized aminoaciduria (HP:0002909)1.73957615
172Anorexia (HP:0002039)1.73540783
173Hemorrhage of the eye (HP:0011885)1.73384633
174Genetic anticipation (HP:0003743)1.72592350
175Abnormality of T cell physiology (HP:0011840)1.72328942
176Myositis (HP:0100614)1.72052189
177Thyroid-stimulating hormone excess (HP:0002925)1.72036807
178Cerebral palsy (HP:0100021)1.71881331
179Metabolic acidosis (HP:0001942)1.71652751
180Aplasia/hypoplasia of the uterus (HP:0008684)1.71139585
181Lethargy (HP:0001254)1.71083131
182Acute hepatic failure (HP:0006554)1.70587737
183Recurrent cutaneous fungal infections (HP:0011370)1.69240854
184Chronic mucocutaneous candidiasis (HP:0002728)1.69240854
185Absent speech (HP:0001344)1.68638710
186Abnormality of renal excretion (HP:0011036)1.67714856
187Abnormality of B cell number (HP:0010975)1.67232283
188Male pseudohermaphroditism (HP:0000037)1.65619182
189Protruding tongue (HP:0010808)1.65471345

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK43.84471448
2PINK13.20956544
3IRAK33.11862175
4ADRBK22.80982562
5BCKDK2.63327732
6TAOK32.41482566
7MAP3K142.29196231
8NME22.28636400
9NUAK12.24642869
10NEK92.18909951
11RIPK42.15292217
12WNK32.04256839
13IRAK11.97065091
14TRPM71.94069084
15ERN11.93309983
16EPHA31.83102908
17TLK11.75579932
18TYK21.73654501
19WNK41.66490776
20EPHB11.65344489
21GRK61.61300247
22ACVR1B1.61059116
23MAP4K21.59887133
24ZAK1.54360681
25TGFBR21.52335195
26FGFR41.52145765
27PBK1.50427238
28PIK3CG1.49946884
29TEC1.49862158
30MARK31.49278613
31PTK2B1.44657381
32DAPK21.44537516
33TXK1.42886444
34IRAK21.42256012
35LATS11.38842091
36TBK11.38413534
37INSRR1.37415637
38RPS6KA41.36554367
39PIM21.35643895
40MAP3K121.35471463
41FRK1.35398169
42SIK11.31624317
43BLK1.31296172
44ERBB41.30999676
45MAPK131.30178488
46MAP2K31.30114105
47OXSR11.29084404
48IKBKE1.25360511
49MAP2K71.20180019
50MAP4K11.20088831
51MAP2K41.18474535
52MAPK111.18137728
53EIF2AK21.15015447
54KDR1.13475252
55KIT1.12714317
56YES11.12372923
57NLK1.10591172
58CSK1.10321970
59ADRBK11.09833381
60CAMKK21.08641669
61GRK11.06039050
62STK38L1.05664207
63MAPK151.05191269
64SIK21.01675171
65IKBKB1.01363211
66PAK31.01003945
67* BTK0.99606350
68CLK10.98909388
69CSF1R0.98602716
70EIF2AK10.97783643
71MAPKAPK30.97647899
72EIF2AK30.96125248
73EPHA20.94672487
74MAP2K60.93045196
75JAK30.92799023
76STK100.91143392
77LYN0.87254164
78PIM10.85784652
79MST1R0.84591255
80CAMK1D0.84584323
81ABL20.84348417
82JAK10.82530190
83MAP3K30.81151258
84SGK20.79842002
85FES0.78485587
86BMPR1B0.77761467
87TIE10.74454869
88CHUK0.73972790
89STK390.73173350
90ZAP700.71723487
91STK110.71496665
92BMPR20.68805074
93FLT30.68717255
94PDK10.68594348
95MAP3K50.68477738
96PRKAA20.68310232
97DYRK20.67764533
98CSNK1G10.67568346
99MARK20.65985995
100PLK40.65884756
101STK30.65734881
102MUSK0.65730089
103CSNK1G20.65132940
104HCK0.64976741
105STK40.64513249
106CSNK1G30.64292864
107CDK30.63811349
108CDK60.63315221
109MATK0.63277058
110MAP3K10.63220763
111SYK0.61823363
112MAP3K70.61618651
113SIK30.61501495
114PRKG20.60504975
115PRKCI0.60311554
116PIK3CA0.60254683
117DYRK30.59400565
118CSNK1A1L0.59072579
119AKT30.58046159
120PHKG20.57141345
121PHKG10.57141345
122ERBB30.56337486
123ABL10.55149647
124OBSCN0.54194562
125MKNK10.53844902
126PRKCQ0.53771790
127PTK60.51731735
128MKNK20.51242459
129PKN10.51225068
130MAPK120.50959033
131PRKCZ0.50663457
132MAPK40.50608765
133MET0.49049406
134PRKCE0.48185525
135PRKD20.47867719
136SGK2230.47756460
137SGK4940.47756460
138GRK50.47411005
139STK160.47101883
140PDPK10.46710096
141MYLK0.46258996
142LCK0.45112682
143TNK20.44972740
144MAP3K110.42569150
145TNIK0.41269624
146CAMK1G0.40980616
147RPS6KA50.40739994
148GRK70.39923676
149CASK0.39626764
150RPS6KA60.39619317
151TTN0.39263806
152ITK0.37376190
153TAOK20.37162138
154PRKCD0.36575348
155CDK70.35944429
156GSK3A0.35811714

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.68741171
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.54771673
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.08921781
4Complement and coagulation cascades_Homo sapiens_hsa046103.01391791
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.83859069
6Staphylococcus aureus infection_Homo sapiens_hsa051502.66079799
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.48554020
8Histidine metabolism_Homo sapiens_hsa003402.22751621
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.17579302
10Tryptophan metabolism_Homo sapiens_hsa003802.15394417
11Arginine biosynthesis_Homo sapiens_hsa002202.13855991
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.13267596
13Steroid hormone biosynthesis_Homo sapiens_hsa001402.12707151
14Peroxisome_Homo sapiens_hsa041462.06085382
15Caffeine metabolism_Homo sapiens_hsa002322.04240858
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.02687023
17Retinol metabolism_Homo sapiens_hsa008301.99001418
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.97890977
19Chemical carcinogenesis_Homo sapiens_hsa052041.95817692
20Fatty acid degradation_Homo sapiens_hsa000711.80893599
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75625789
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68692856
23Nitrogen metabolism_Homo sapiens_hsa009101.66715045
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66564634
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.66173314
26Phototransduction_Homo sapiens_hsa047441.63119279
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57959011
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.57932620
29beta-Alanine metabolism_Homo sapiens_hsa004101.56876196
30Steroid biosynthesis_Homo sapiens_hsa001001.55059344
31One carbon pool by folate_Homo sapiens_hsa006701.54555065
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54094965
33Sulfur metabolism_Homo sapiens_hsa009201.52303106
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.51504323
35Folate biosynthesis_Homo sapiens_hsa007901.51306727
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.50504109
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.48336716
38Primary immunodeficiency_Homo sapiens_hsa053401.47257335
39Ether lipid metabolism_Homo sapiens_hsa005651.46914007
40Starch and sucrose metabolism_Homo sapiens_hsa005001.44015464
41Selenocompound metabolism_Homo sapiens_hsa004501.32959319
42Olfactory transduction_Homo sapiens_hsa047401.31435732
43Basal transcription factors_Homo sapiens_hsa030221.28484874
44PPAR signaling pathway_Homo sapiens_hsa033201.26105759
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22346550
46Fatty acid elongation_Homo sapiens_hsa000621.21453156
47Propanoate metabolism_Homo sapiens_hsa006401.21076524
48ABC transporters_Homo sapiens_hsa020101.20450218
49Regulation of autophagy_Homo sapiens_hsa041401.15858715
50Tyrosine metabolism_Homo sapiens_hsa003501.13440799
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12503129
52Vitamin digestion and absorption_Homo sapiens_hsa049771.10787694
53Fatty acid metabolism_Homo sapiens_hsa012121.08301700
54T cell receptor signaling pathway_Homo sapiens_hsa046601.07443701
55Phenylalanine metabolism_Homo sapiens_hsa003601.06552935
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03988532
57Type I diabetes mellitus_Homo sapiens_hsa049401.03065415
58Platelet activation_Homo sapiens_hsa046110.98846408
59Collecting duct acid secretion_Homo sapiens_hsa049660.96657933
60Arginine and proline metabolism_Homo sapiens_hsa003300.95145621
61Ovarian steroidogenesis_Homo sapiens_hsa049130.93940889
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.92708350
63Protein export_Homo sapiens_hsa030600.92005842
64Oxidative phosphorylation_Homo sapiens_hsa001900.91256648
65Dorso-ventral axis formation_Homo sapiens_hsa043200.90994033
66Vitamin B6 metabolism_Homo sapiens_hsa007500.89973692
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89659947
68Glycerolipid metabolism_Homo sapiens_hsa005610.89111188
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.88971889
70Leishmaniasis_Homo sapiens_hsa051400.88293230
71Butanoate metabolism_Homo sapiens_hsa006500.87571081
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87037565
73Glutathione metabolism_Homo sapiens_hsa004800.86880381
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86284803
75RNA polymerase_Homo sapiens_hsa030200.85638003
76B cell receptor signaling pathway_Homo sapiens_hsa046620.85102581
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.84959793
78* NF-kappa B signaling pathway_Homo sapiens_hsa040640.82825237
79Sulfur relay system_Homo sapiens_hsa041220.80838569
80Serotonergic synapse_Homo sapiens_hsa047260.79180227
81Insulin secretion_Homo sapiens_hsa049110.77224065
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.76152213
83Arachidonic acid metabolism_Homo sapiens_hsa005900.75910090
84Fat digestion and absorption_Homo sapiens_hsa049750.75141060
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75056486
86Other glycan degradation_Homo sapiens_hsa005110.73120895
87Malaria_Homo sapiens_hsa051440.72837390
88Circadian rhythm_Homo sapiens_hsa047100.69752370
89Taste transduction_Homo sapiens_hsa047420.68039451
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67738538
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.67597874
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67346699
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62353004
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.61427583
95Lysine degradation_Homo sapiens_hsa003100.59510295
96Chemokine signaling pathway_Homo sapiens_hsa040620.59111172
97Legionellosis_Homo sapiens_hsa051340.59029424
98Insulin resistance_Homo sapiens_hsa049310.58821999
99Rheumatoid arthritis_Homo sapiens_hsa053230.58010642
100* Tuberculosis_Homo sapiens_hsa051520.56723837
101Morphine addiction_Homo sapiens_hsa050320.54510986
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52793986
103Pentose phosphate pathway_Homo sapiens_hsa000300.52357339
104Metabolic pathways_Homo sapiens_hsa011000.51911386
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50785785
106* Pertussis_Homo sapiens_hsa051330.50781414
107Lysosome_Homo sapiens_hsa041420.50333287
108Measles_Homo sapiens_hsa051620.50193801
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.49888124
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49044095
111* Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48997518
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48807217
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48242725
114Parkinsons disease_Homo sapiens_hsa050120.46763859
115Bile secretion_Homo sapiens_hsa049760.46437292
116Linoleic acid metabolism_Homo sapiens_hsa005910.46200615
117Pyruvate metabolism_Homo sapiens_hsa006200.45940957
118Fanconi anemia pathway_Homo sapiens_hsa034600.44205638
119Type II diabetes mellitus_Homo sapiens_hsa049300.43876047
120TNF signaling pathway_Homo sapiens_hsa046680.43055490
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.41962198
122Graft-versus-host disease_Homo sapiens_hsa053320.41395413
123Herpes simplex infection_Homo sapiens_hsa051680.41062897
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40493703
125Carbon metabolism_Homo sapiens_hsa012000.40256452
126Hematopoietic cell lineage_Homo sapiens_hsa046400.40208783
127Galactose metabolism_Homo sapiens_hsa000520.40033963
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39520593
129Biosynthesis of amino acids_Homo sapiens_hsa012300.39450320
130RNA degradation_Homo sapiens_hsa030180.38210439
131Glutamatergic synapse_Homo sapiens_hsa047240.37526910
132Homologous recombination_Homo sapiens_hsa034400.34928843
133Pyrimidine metabolism_Homo sapiens_hsa002400.32504452
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30373530
135DNA replication_Homo sapiens_hsa030300.29759623
136Influenza A_Homo sapiens_hsa051640.29505502
137Hepatitis C_Homo sapiens_hsa051600.27204538
138Allograft rejection_Homo sapiens_hsa053300.26950939
139Asthma_Homo sapiens_hsa053100.26298236
140Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25270963
141Autoimmune thyroid disease_Homo sapiens_hsa053200.24237073
142African trypanosomiasis_Homo sapiens_hsa051430.23734495
143Osteoclast differentiation_Homo sapiens_hsa043800.22423910
144Systemic lupus erythematosus_Homo sapiens_hsa053220.21616248

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