TJAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a tight junction-associated protein. Incorporation of the encoded protein into tight junctions occurs at a late stage of formation of the junctions. The encoded protein localizes to the Golgi and may function in vesicle trafficking. Alternatively spliced transcript variants have been described. A related pseudogene exists on the X chromosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.88433976
2axon ensheathment in central nervous system (GO:0032291)8.88433976
3striatum development (GO:0021756)6.43551025
4axon ensheathment (GO:0008366)6.20404901
5ensheathment of neurons (GO:0007272)6.20404901
6myelination (GO:0042552)6.10962994
7cerebellar granule cell differentiation (GO:0021707)5.86484041
8cell morphogenesis involved in neuron differentiation (GO:0048667)5.60568651
9stem cell development (GO:0048864)5.55695775
10maternal behavior (GO:0042711)5.55324820
11neuron fate determination (GO:0048664)5.48324440
12negative regulation of oligodendrocyte differentiation (GO:0048715)5.43025204
13neuronal stem cell maintenance (GO:0097150)5.35575298
14nephron tubule morphogenesis (GO:0072078)5.28084372
15nephron epithelium morphogenesis (GO:0072088)5.28084372
16fatty acid elongation (GO:0030497)5.22408578
17positive regulation of astrocyte differentiation (GO:0048711)4.90075478
18parental behavior (GO:0060746)4.80042776
19radial glial cell differentiation (GO:0060019)4.79907668
20heart valve formation (GO:0003188)4.74921746
21nucleoside transmembrane transport (GO:1901642)4.73821101
22axon extension involved in axon guidance (GO:0048846)4.70371396
23neuron projection extension involved in neuron projection guidance (GO:1902284)4.70371396
24sulfation (GO:0051923)4.63680359
25cochlea development (GO:0090102)4.59422594
26negative regulation of smooth muscle cell differentiation (GO:0051151)4.49959656
27dopamine transport (GO:0015872)4.49254895
28phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.48425968
29regulation of cardioblast proliferation (GO:0003264)4.44398848
30regulation of secondary heart field cardioblast proliferation (GO:0003266)4.44398848
31establishment of nucleus localization (GO:0040023)4.39318690
32glomerular basement membrane development (GO:0032836)4.35458576
33negative regulation by host of viral transcription (GO:0043922)4.25812538
34negative regulation of glial cell proliferation (GO:0060253)4.18298731
35negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.11850716
36renal tubule morphogenesis (GO:0061333)4.03012612
37myelin maintenance (GO:0043217)3.95976501
38regulation of timing of cell differentiation (GO:0048505)3.94016111
39peristalsis (GO:0030432)3.93646438
40transmission of nerve impulse (GO:0019226)3.91436087
41substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.87205044
42substrate-independent telencephalic tangential migration (GO:0021826)3.87205044
43cell proliferation in forebrain (GO:0021846)3.84402465
44negative regulation of axon guidance (GO:1902668)3.82673195
45cholesterol biosynthetic process (GO:0006695)3.81309221
46creatine metabolic process (GO:0006600)3.80638737
47cell proliferation involved in metanephros development (GO:0072203)3.79684757
48mesenchymal cell development (GO:0014031)3.78184145
49labyrinthine layer blood vessel development (GO:0060716)3.78054474
50neural crest cell development (GO:0014032)3.78028061
51astrocyte development (GO:0014002)3.76865765
52virion attachment to host cell (GO:0019062)3.75590344
53adhesion of symbiont to host cell (GO:0044650)3.75590344
54neuronal action potential (GO:0019228)3.74460983
55negative regulation of leukocyte chemotaxis (GO:0002689)3.72374786
56somatic stem cell division (GO:0048103)3.69030344
57negative regulation of axon extension (GO:0030517)3.62729001
58regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.62120152
59mating behavior (GO:0007617)3.61849279
60dorsal/ventral neural tube patterning (GO:0021904)3.61316043
61pyrimidine dimer repair (GO:0006290)3.60183759
62positive regulation of male gonad development (GO:2000020)3.60033872
63ventricular septum morphogenesis (GO:0060412)3.56843928
64negative regulation of inclusion body assembly (GO:0090084)3.55841916
65negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.53125137
66regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.52142063
67telencephalon development (GO:0021537)3.52090899
68myelination in peripheral nervous system (GO:0022011)3.50153766
69peripheral nervous system axon ensheathment (GO:0032292)3.50153766
70prepulse inhibition (GO:0060134)3.47591077
71outflow tract septum morphogenesis (GO:0003148)3.46491478
72asymmetric protein localization (GO:0008105)3.39988616
73cellular response to hepatocyte growth factor stimulus (GO:0035729)3.38864367
74response to hepatocyte growth factor (GO:0035728)3.38864367
75negative regulation of epidermis development (GO:0045683)3.38850339
76lateral sprouting from an epithelium (GO:0060601)3.35790337
77histone mRNA catabolic process (GO:0071044)3.35616958
78apical protein localization (GO:0045176)3.35261427
79cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.34451112
80mitotic nuclear envelope reassembly (GO:0007084)3.33489926
81nuclear envelope reassembly (GO:0031468)3.33489926
82positive regulation of Notch signaling pathway (GO:0045747)3.33078899
833-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.32695434
84purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.32695434
85sterol biosynthetic process (GO:0016126)3.31443042
86regulation of mesenchymal cell apoptotic process (GO:2001053)3.29184267
87regulation of development, heterochronic (GO:0040034)3.28827866
88chemosensory behavior (GO:0007635)3.27807676
89nucleus localization (GO:0051647)3.25355276
90apoptotic process involved in morphogenesis (GO:0060561)3.25353638
91cell aggregation (GO:0098743)3.24783642
92cartilage condensation (GO:0001502)3.24783642
93oligodendrocyte differentiation (GO:0048709)3.24538889
94endocardial cushion morphogenesis (GO:0003203)3.23160263
95lens fiber cell development (GO:0070307)3.22969876
96long-chain fatty acid biosynthetic process (GO:0042759)3.21943238
97negative regulation of epidermal cell differentiation (GO:0045605)3.20203277
98somatic stem cell maintenance (GO:0035019)3.19125818
99regulation of heart morphogenesis (GO:2000826)3.18643413
100positive regulation by host of viral transcription (GO:0043923)3.17329271
101astrocyte differentiation (GO:0048708)3.16024774
102sex differentiation (GO:0007548)3.15674760
103negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.14920595
104regulation of response to osmotic stress (GO:0047484)3.12530749
105negative regulation of chondrocyte differentiation (GO:0032331)3.11241389
106regulation of collateral sprouting (GO:0048670)3.08609723
107polarized epithelial cell differentiation (GO:0030859)3.07993062
108amyloid precursor protein metabolic process (GO:0042982)3.07289500
109bone trabecula formation (GO:0060346)3.05807675
110protein localization to endosome (GO:0036010)3.02109128
111establishment of mitotic spindle localization (GO:0040001)3.01619797
112renal system development (GO:0072001)3.01328264
113left/right axis specification (GO:0070986)3.01265919
114cysteine metabolic process (GO:0006534)3.00175772
115negative regulation of myoblast differentiation (GO:0045662)2.99718399
116somite development (GO:0061053)2.99493603
117membrane tubulation (GO:0097320)2.99229129
118negative regulation of glial cell differentiation (GO:0045686)2.98896718
119regulation of astrocyte differentiation (GO:0048710)2.97755983
120protein refolding (GO:0042026)2.97115265
121midbrain development (GO:0030901)2.94827596
122regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.94188529
123regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.94188529
124regulation of axon guidance (GO:1902667)2.91880828
125DNA unwinding involved in DNA replication (GO:0006268)2.91832545
126establishment of mitotic spindle orientation (GO:0000132)2.91239373
127mesenchyme morphogenesis (GO:0072132)2.90571286
128establishment of mitochondrion localization (GO:0051654)2.89136358
129ear development (GO:0043583)2.88846985
130adhesion of symbiont to host (GO:0044406)2.88434567
131primary amino compound metabolic process (GO:1901160)2.87666222
132nucleoside transport (GO:0015858)2.87074641
133regulation of organ formation (GO:0003156)2.86397444
134negative regulation of protein autophosphorylation (GO:0031953)2.85858276
135cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.85594250
136establishment or maintenance of apical/basal cell polarity (GO:0035088)2.80697217
137establishment or maintenance of bipolar cell polarity (GO:0061245)2.80697217
138substantia nigra development (GO:0021762)2.79917084
139negative regulation of neurotransmitter secretion (GO:0046929)2.76247714
140regulation of gene silencing by RNA (GO:0060966)2.73087135
141regulation of posttranscriptional gene silencing (GO:0060147)2.73087135
142regulation of gene silencing by miRNA (GO:0060964)2.73087135
143negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.72002470
144eye photoreceptor cell differentiation (GO:0001754)2.71546581
145photoreceptor cell differentiation (GO:0046530)2.71546581
146positive regulation of actin filament depolymerization (GO:0030836)2.69677246
147regulation of myelination (GO:0031641)2.67181372
148regulation of hippo signaling (GO:0035330)2.64869515
149isoprenoid biosynthetic process (GO:0008299)2.62876038
150response to lipoprotein particle (GO:0055094)2.62477878
151renal filtration (GO:0097205)2.62307917
152glomerular filtration (GO:0003094)2.61963814
153glial cell development (GO:0021782)2.58041528
154regulation of exit from mitosis (GO:0007096)2.57002265
155establishment of spindle orientation (GO:0051294)2.55076112
156negative regulation of protein localization to cell surface (GO:2000009)2.52983197
157membrane protein ectodomain proteolysis (GO:0006509)2.52292132
158regulation of cardioblast differentiation (GO:0051890)2.51676295
159cellular protein complex localization (GO:0034629)2.51608711
160peptidyl-tyrosine autophosphorylation (GO:0038083)2.50622661
161amyloid precursor protein catabolic process (GO:0042987)2.47931767
162microtubule polymerization or depolymerization (GO:0031109)2.46394187
163epithelial cell fate commitment (GO:0072148)2.45581133
164negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.45099779
165Leydig cell differentiation (GO:0033327)2.44950126
166response to redox state (GO:0051775)2.44824863
167glycerophospholipid catabolic process (GO:0046475)2.44232494
168cell fate commitment involved in formation of primary germ layer (GO:0060795)2.43697494
169regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.41950876
170apoptotic process involved in development (GO:1902742)2.41622039
171positive regulation of pseudopodium assembly (GO:0031274)2.39674039
172protein localization to kinetochore (GO:0034501)2.38750192
173microtubule severing (GO:0051013)2.37446294
174positive regulation of chromosome segregation (GO:0051984)2.35625129
175wound healing, spreading of cells (GO:0044319)2.35200674
176mitotic cytokinesis (GO:0000281)2.33720613
177positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.32297825
178cortical actin cytoskeleton organization (GO:0030866)2.32042909
179oligodendrocyte development (GO:0014003)2.29486742
180establishment of spindle localization (GO:0051293)2.29342284
181positive regulation of neurological system process (GO:0031646)2.29160423
182actin filament depolymerization (GO:0030042)2.29086774
183regulation of RNA export from nucleus (GO:0046831)2.27927463
184heterochromatin organization (GO:0070828)2.27638177
185mesodermal cell differentiation (GO:0048333)2.27426818
186positive regulation of gene expression, epigenetic (GO:0045815)2.27392013
187protein palmitoylation (GO:0018345)2.26645764
188establishment of apical/basal cell polarity (GO:0035089)2.26094004
189endocardial cushion development (GO:0003197)2.25805849
190DNA replication-dependent nucleosome assembly (GO:0006335)2.25190838
191DNA replication-dependent nucleosome organization (GO:0034723)2.25190838
192branching involved in mammary gland duct morphogenesis (GO:0060444)2.24544551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse5.31681760
2EZH2_22144423_ChIP-Seq_EOC_Human5.13612506
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.01958167
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.75203370
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.66693911
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.64049712
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.38906063
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.38906063
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.38906063
10ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.07841076
11AR_21572438_ChIP-Seq_LNCaP_Human3.00735824
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.69820617
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.32549774
14E2F7_22180533_ChIP-Seq_HELA_Human2.31004757
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.26975940
16* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26853034
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.22136534
18ZNF274_21170338_ChIP-Seq_K562_Hela2.18304862
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.17468201
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.15613007
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.14968021
22GBX2_23144817_ChIP-Seq_PC3_Human2.14747462
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.07775348
24DROSHA_22980978_ChIP-Seq_HELA_Human2.05635690
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.01413448
26TCF3_18692474_ChIP-Seq_MEFs_Mouse2.00299142
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99863389
28GATA1_22025678_ChIP-Seq_K562_Human1.99016913
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97496734
30SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.95605806
31ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.95377879
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95201556
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.94531672
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93945990
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.93190095
36RUNX_20019798_ChIP-Seq_JUKART_Human1.91243874
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.89037472
38* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.86322260
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.84063163
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.83699898
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.83535111
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.83455683
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81956156
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.79950772
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.78618875
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.77487589
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.77451936
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.75182363
49TCF3_18692474_ChIP-Seq_MESCs_Mouse1.73871064
50TP53_22127205_ChIP-Seq_IMR90_Human1.73120807
51NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.72779547
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.71440927
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.69745263
54* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.69030357
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68912591
56AR_21909140_ChIP-Seq_LNCAP_Human1.68594017
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.67415398
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66767236
59SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.62393098
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61496149
61JARID2_20064375_ChIP-Seq_MESCs_Mouse1.61092005
62XRN2_22483619_ChIP-Seq_HELA_Human1.60233901
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59088076
64RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.59086055
65VDR_21846776_ChIP-Seq_THP-1_Human1.56950433
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55512057
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54564654
68RXR_22108803_ChIP-Seq_LS180_Human1.54012676
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.53568605
70EZH2_18974828_ChIP-Seq_MESCs_Mouse1.53568605
71EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.53501930
72MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52527542
73NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.51869421
74NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.51811227
75* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49861002
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.46699758
77ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.46431922
78* KDM2B_26808549_Chip-Seq_DND41_Human1.43803136
79RING1B_27294783_Chip-Seq_ESCs_Mouse1.43354040
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43022448
81* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42726806
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41533677
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41391821
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.40864413
85EST1_17652178_ChIP-ChIP_JURKAT_Human1.40641001
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.40254307
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39696058
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.38618087
89IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38162854
90ETS1_20019798_ChIP-Seq_JURKAT_Human1.37094517
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36938914
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36491067
93MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35422994
94GATA1_26923725_Chip-Seq_HPCs_Mouse1.33708709
95WT1_19549856_ChIP-ChIP_CCG9911_Human1.33406769
96NANOG_18692474_ChIP-Seq_MEFs_Mouse1.32633665
97NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32032324
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31322327
99P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31219564
100SOX2_18692474_ChIP-Seq_MEFs_Mouse1.31190183
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31156326
102EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30954047
103SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30820302
104* RACK7_27058665_Chip-Seq_MCF-7_Human1.30686126
105SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29848710
106FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28904891
107TP53_16413492_ChIP-PET_HCT116_Human1.27610694
108MYC_22102868_ChIP-Seq_BL_Human1.26630053
109TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.26573882
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26161140
111TP53_20018659_ChIP-ChIP_R1E_Mouse1.25453725
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24224684
113* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23597674
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.23482683
115POU5F1_16518401_ChIP-PET_MESCs_Mouse1.23198825
116* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.21947142
117NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20933203
118CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20632889
119SMC3_22415368_ChIP-Seq_MEFs_Mouse1.19602584
120SOX2_16153702_ChIP-ChIP_HESCs_Human1.19161181
121TBX3_20139965_ChIP-Seq_MESCs_Mouse1.19001690
122P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.18955249
123NANOG_18692474_ChIP-Seq_MESCs_Mouse1.17762642
124SOX2_18692474_ChIP-Seq_MESCs_Mouse1.17540771
125TBX3_20139965_ChIP-Seq_ESCs_Mouse1.17313656
126CBX2_27304074_Chip-Seq_ESCs_Mouse1.17282762
127ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17048204
128KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16019492
129SMC4_20622854_ChIP-Seq_HELA_Human1.15976493
130CDX2_20551321_ChIP-Seq_CACO-2_Human1.15018487
131ERA_21632823_ChIP-Seq_H3396_Human1.14945833
132OCT4_18692474_ChIP-Seq_MEFs_Mouse1.14855772
133THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12709427
134PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10157490
135RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10135870
136STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.09471899
137VDR_22108803_ChIP-Seq_LS180_Human1.09259471
138FOXO3_23340844_ChIP-Seq_DLD1_Human1.07189581
139MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07131210
140CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06942597
141* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06392791
142EP300_21415370_ChIP-Seq_HL-1_Mouse1.04845797
143BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04513409
144SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.03328845
145* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03023864
146TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02673468
147POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02673468
148YY1_22570637_ChIP-Seq_MALME-3M_Human1.01837855
149POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01039581
150PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.00375408
151PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00309560
152KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99352679
153KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99044406
154MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98951202
155OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98898716
156ESR2_21235772_ChIP-Seq_MCF-7_Human0.98235379
157FOXP1_21924763_ChIP-Seq_HESCs_Human0.97577158
158WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97320983
159JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.97071813
160CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96845557
161* TP53_23651856_ChIP-Seq_MEFs_Mouse0.96756033
162TET1_21451524_ChIP-Seq_MESCs_Mouse0.96668455
163POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.96517825
164SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95587172
165NANOG_21062744_ChIP-ChIP_HESCs_Human0.95049169
166ATF3_27146783_Chip-Seq_COLON_Human0.94616008
167REST_21632747_ChIP-Seq_MESCs_Mouse0.94166751
168SOX17_20123909_ChIP-Seq_XEN_Mouse0.94018618
169NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93843871
170CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93569128
171ISL1_27105846_Chip-Seq_CPCs_Mouse0.91539714
172KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88981007
173RING1B_27294783_Chip-Seq_NPCs_Mouse0.87801645
174SA1_27219007_Chip-Seq_ERYTHROID_Human0.87720778
175CTCF_27219007_Chip-Seq_Bcells_Human0.87689787
176MYC_27129775_Chip-Seq_CORNEA_Mouse0.87273209
177PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86917248
178ELK4_26923725_Chip-Seq_MESODERM_Mouse0.86298588
179SCL_19346495_ChIP-Seq_HPC-7_Human0.85545114
180IRF1_19129219_ChIP-ChIP_H3396_Human0.82852040
181SA1_27219007_Chip-Seq_Bcells_Human0.82213848
182SOX3_22085726_ChIP-Seq_NPCs_Mouse0.81880750
183* TP63_22573176_ChIP-Seq_HFKS_Human0.81156562
184REST_18959480_ChIP-ChIP_MESCs_Mouse0.80979125
185P68_20966046_ChIP-Seq_HELA_Human0.80310049
186* LXR_22292898_ChIP-Seq_THP-1_Human0.80204667
187* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.79367395
188SMAD3_21741376_ChIP-Seq_EPCs_Human0.78794225
189SOX2_21211035_ChIP-Seq_LN229_Human0.77996471

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern7.68088594
2MP0003283_abnormal_digestive_organ3.64196761
3MP0003950_abnormal_plasma_membrane3.56063370
4MP0010030_abnormal_orbit_morphology3.48811620
5MP0005084_abnormal_gallbladder_morpholo3.31679686
6MP0000920_abnormal_myelination3.16793130
7MP0002928_abnormal_bile_duct3.14533296
8MP0008438_abnormal_cutaneous_collagen2.99233715
9MP0003890_abnormal_embryonic-extraembry2.74991637
10MP0005623_abnormal_meninges_morphology2.71894425
11MP0000569_abnormal_digit_pigmentation2.40379871
12MP0002653_abnormal_ependyma_morphology2.31543516
13MP0000733_abnormal_muscle_development2.12698850
14MP0002282_abnormal_trachea_morphology2.12552074
15MP0008057_abnormal_DNA_replication2.07170421
16MP0003937_abnormal_limbs/digits/tail_de2.02235890
17MP0000566_synostosis1.96744951
18MP0002277_abnormal_respiratory_mucosa1.92128084
19MP0000462_abnormal_digestive_system1.88266465
20MP0005174_abnormal_tail_pigmentation1.86730568
21MP0001286_abnormal_eye_development1.86033233
22MP0005171_absent_coat_pigmentation1.84904216
23MP0005248_abnormal_Harderian_gland1.84331399
24MP0008932_abnormal_embryonic_tissue1.82029425
25MP0001485_abnormal_pinna_reflex1.80981663
26MP0004272_abnormal_basement_membrane1.78061643
27MP0000026_abnormal_inner_ear1.76869697
28MP0001730_embryonic_growth_arrest1.72728201
29MP0006138_congestive_heart_failure1.69211565
30MP0000383_abnormal_hair_follicle1.62508021
31MP0004134_abnormal_chest_morphology1.62352262
32MP0003011_delayed_dark_adaptation1.60709139
33MP0000762_abnormal_tongue_morphology1.58516897
34MP0002089_abnormal_postnatal_growth/wei1.57764565
35MP0000747_muscle_weakness1.56822567
36MP0002085_abnormal_embryonic_tissue1.56309224
37MP0009840_abnormal_foam_cell1.53933833
38MP0000537_abnormal_urethra_morphology1.52550155
39MP0004957_abnormal_blastocyst_morpholog1.50616764
40MP0000613_abnormal_salivary_gland1.48517952
41MP0009379_abnormal_foot_pigmentation1.46946127
42MP0004133_heterotaxia1.46833135
43MP0003938_abnormal_ear_development1.45255028
44MP0010678_abnormal_skin_adnexa1.44531377
45MP0002084_abnormal_developmental_patter1.44353263
46MP0004885_abnormal_endolymph1.41061931
47MP0000428_abnormal_craniofacial_morphol1.39683270
48MP0003806_abnormal_nucleotide_metabolis1.37171278
49MP0003385_abnormal_body_wall1.36289165
50MP0003634_abnormal_glial_cell1.35415392
51MP0000467_abnormal_esophagus_morphology1.35351200
52MP0005451_abnormal_body_composition1.34512585
53MP0003077_abnormal_cell_cycle1.34499977
54MP0000749_muscle_degeneration1.32203444
55MP0004185_abnormal_adipocyte_glucose1.29975322
56MP0001672_abnormal_embryogenesis/_devel1.28306705
57MP0005380_embryogenesis_phenotype1.28306705
58MP0000350_abnormal_cell_proliferation1.27397975
59MP0003755_abnormal_palate_morphology1.26376501
60MP0003984_embryonic_growth_retardation1.24970658
61MP0000750_abnormal_muscle_regeneration1.24445670
62MP0001697_abnormal_embryo_size1.24392411
63MP0004197_abnormal_fetal_growth/weight/1.21046269
64MP0002932_abnormal_joint_morphology1.20836845
65MP0003705_abnormal_hypodermis_morpholog1.20595355
66MP0002088_abnormal_embryonic_growth/wei1.19965817
67MP0004087_abnormal_muscle_fiber1.19750826
68MP0002111_abnormal_tail_morphology1.16773259
69MP0001849_ear_inflammation1.16770880
70MP0000955_abnormal_spinal_cord1.16457898
71MP0003632_abnormal_nervous_system1.16024524
72MP0003111_abnormal_nucleus_morphology1.14766888
73MP0001299_abnormal_eye_distance/1.13824556
74MP0001727_abnormal_embryo_implantation1.13544686
75MP0003091_abnormal_cell_migration1.12972454
76MP0000759_abnormal_skeletal_muscle1.12515656
77MP0003690_abnormal_glial_cell1.12186220
78MP0004142_abnormal_muscle_tone1.12040901
79MP0001984_abnormal_olfaction1.11887982
80MP0000049_abnormal_middle_ear1.09951986
81MP0003453_abnormal_keratinocyte_physiol1.09245400
82MP0002116_abnormal_craniofacial_bone1.09142510
83MP0003136_yellow_coat_color1.08638472
84MP0005508_abnormal_skeleton_morphology1.07160945
85MP0001529_abnormal_vocalization1.06245959
86MP0009250_abnormal_appendicular_skeleto1.06185220
87MP0005410_abnormal_fertilization1.05808076
88MP0010630_abnormal_cardiac_muscle1.05494879
89MP0001293_anophthalmia1.05222521
90MP0003279_aneurysm1.04029829
91MP0002751_abnormal_autonomic_nervous1.03650680
92MP0004742_abnormal_vestibular_system1.02773945
93MP0003861_abnormal_nervous_system1.02525496
94MP0001348_abnormal_lacrimal_gland1.02504532
95MP0003935_abnormal_craniofacial_develop1.00727900
96MP0002925_abnormal_cardiovascular_devel1.00086983
97MP0003119_abnormal_digestive_system1.00018289
98MP0004145_abnormal_muscle_electrophysio0.99567958
99MP0005551_abnormal_eye_electrophysiolog0.99376303
100MP0002064_seizures0.98521010
101MP0002102_abnormal_ear_morphology0.98133847
102MP0002269_muscular_atrophy0.98060133
103MP0000343_altered_response_to0.98006567
104MP0005083_abnormal_biliary_tract0.97907689
105MP0001346_abnormal_lacrimal_gland0.97896727
106MP0005023_abnormal_wound_healing0.97886086
107MP0003329_amyloid_beta_deposits0.97829851
108MP0002080_prenatal_lethality0.96941291
109MP0001958_emphysema0.95809131
110MP0000432_abnormal_head_morphology0.95609946
111MP0002092_abnormal_eye_morphology0.93165748
112MP0001243_abnormal_dermal_layer0.92364848
113MP0002249_abnormal_larynx_morphology0.91775526
114MP0005330_cardiomyopathy0.91178303
115MP0005390_skeleton_phenotype0.91063568
116MP0002114_abnormal_axial_skeleton0.91058518
117MP0005595_abnormal_vascular_smooth0.91016221
118MP0000778_abnormal_nervous_system0.90706346
119MP0002086_abnormal_extraembryonic_tissu0.89083285
120MP0000534_abnormal_ureter_morphology0.88928963
121MP0002067_abnormal_sensory_capabilities0.87397015
122MP0009384_cardiac_valve_regurgitation0.86400480
123MP0002184_abnormal_innervation0.86119404
124MP0002752_abnormal_somatic_nervous0.85350934
125MP0002106_abnormal_muscle_physiology0.85307581
126MP0005257_abnormal_intraocular_pressure0.85186876
127MP0000631_abnormal_neuroendocrine_gland0.84773144
128MP0004147_increased_porphyrin_level0.84618881
129MP0003566_abnormal_cell_adhesion0.84475579
130MP0003115_abnormal_respiratory_system0.82840638
131MP0003137_abnormal_impulse_conducting0.82689696
132MP0010352_gastrointestinal_tract_polyps0.82566052
133MP0008569_lethality_at_weaning0.82175371
134MP0001915_intracranial_hemorrhage0.81136180
135MP0005195_abnormal_posterior_eye0.80477856
136MP0001614_abnormal_blood_vessel0.80355448
137MP0005369_muscle_phenotype0.79370310
138MP0000647_abnormal_sebaceous_gland0.77007598
139MP0003959_abnormal_lean_body0.75613966
140MP0002938_white_spotting0.74898072
141MP0003879_abnormal_hair_cell0.73488901
142MP0001270_distended_abdomen0.72141345
143MP0002272_abnormal_nervous_system0.70221493
144MP0002697_abnormal_eye_size0.70219420
145MP0005197_abnormal_uvea_morphology0.68396876
146MP0001986_abnormal_taste_sensitivity0.67039627
147MP0002233_abnormal_nose_morphology0.66776772
148MP0009745_abnormal_behavioral_response0.66196617
149MP0000163_abnormal_cartilage_morphology0.65784697
150MP0001324_abnormal_eye_pigmentation0.64286156
151MP0008058_abnormal_DNA_repair0.63567169
152MP0003122_maternal_imprinting0.63526067
153MP0002638_abnormal_pupillary_reflex0.61741360
154MP0001486_abnormal_startle_reflex0.61736775
155MP0002882_abnormal_neuron_morphology0.61103562
156MP0003936_abnormal_reproductive_system0.60952207
157MP0005423_abnormal_somatic_nervous0.60814009
158MP0001963_abnormal_hearing_physiology0.60468120
159MP0002152_abnormal_brain_morphology0.60017261
160MP0010329_abnormal_lipoprotein_level0.59661775
161MP0003635_abnormal_synaptic_transmissio0.58627271
162MP0003252_abnormal_bile_duct0.58605760
163MP0001502_abnormal_circadian_rhythm0.55775541
164MP0008007_abnormal_cellular_replicative0.52778499
165MP0001340_abnormal_eyelid_morphology0.52693975
166MP0002234_abnormal_pharynx_morphology0.52527950
167MP0001944_abnormal_pancreas_morphology0.51269283

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the pubic bone (HP:0009104)6.54010948
2Oligodactyly (hands) (HP:0001180)5.19058753
3Type II lissencephaly (HP:0007260)5.15933727
4Spastic paraparesis (HP:0002313)5.14665025
5Fibular aplasia (HP:0002990)5.02342299
6Split foot (HP:0001839)4.88507229
7Abnormality of the pons (HP:0007361)4.33038454
8Humeroradial synostosis (HP:0003041)4.33010330
9Synostosis involving the elbow (HP:0003938)4.33010330
10Hypoplasia of the pons (HP:0012110)4.31210784
11Sensory axonal neuropathy (HP:0003390)4.26169290
12Adactyly (HP:0009776)4.22890079
13Premature rupture of membranes (HP:0001788)4.07241973
14Annular pancreas (HP:0001734)4.02743866
15Muscle hypertrophy of the lower extremities (HP:0008968)3.91091435
16Cerebellar dysplasia (HP:0007033)3.87280525
17Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.72622673
18Degeneration of the lateral corticospinal tracts (HP:0002314)3.72622673
19Aplastic anemia (HP:0001915)3.69401257
20Congenital stationary night blindness (HP:0007642)3.69390911
21Chromosomal breakage induced by crosslinking agents (HP:0003221)3.60124976
22Hypoplastic nipples (HP:0002557)3.60028727
23Calf muscle hypertrophy (HP:0008981)3.54419046
24Oligodactyly (HP:0012165)3.54023910
25Cerebral hypomyelination (HP:0006808)3.47298116
26Abnormal finger flexion creases (HP:0006143)3.45546910
27Esophageal atresia (HP:0002032)3.41558703
28Abnormality of DNA repair (HP:0003254)3.41007024
29Paraparesis (HP:0002385)3.40964220
30Aplasia/hypoplasia of the uterus (HP:0008684)3.40431101
31Anophthalmia (HP:0000528)3.37815134
32Abnormality of the pubic bones (HP:0003172)3.31630207
33Broad ribs (HP:0000885)3.28446843
34Abnormal pancreas size (HP:0012094)3.24645286
35Aplasia/Hypoplasia of the 5th finger (HP:0006262)3.21855874
36Muscle fiber splitting (HP:0003555)3.20859464
37Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.10758777
38Radial bowing (HP:0002986)3.10364355
39Partial duplication of thumb phalanx (HP:0009944)3.09030991
40Meningocele (HP:0002435)3.05108904
41Progressive cerebellar ataxia (HP:0002073)3.00193970
42Hypoplastic iliac wings (HP:0002866)2.98731874
43Premature skin wrinkling (HP:0100678)2.98653627
44Partial duplication of the phalanx of hand (HP:0009999)2.97608851
45Coronal craniosynostosis (HP:0004440)2.96260711
46Parakeratosis (HP:0001036)2.95960434
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.90012669
48Chromsome breakage (HP:0040012)2.90005815
49Alacrima (HP:0000522)2.87775316
50Round ear (HP:0100830)2.83374203
51Ulnar bowing (HP:0003031)2.80436263
52Protrusio acetabuli (HP:0003179)2.78906642
53True hermaphroditism (HP:0010459)2.73019266
54Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.68979201
55Shallow orbits (HP:0000586)2.67777943
56Tarsal synostosis (HP:0008368)2.67631364
57Entropion (HP:0000621)2.64753533
58Hemiparesis (HP:0001269)2.62006567
59Aplasia/Hypoplasia of the fibula (HP:0006492)2.60089144
60Synostosis involving bones of the feet (HP:0009140)2.56550141
61Synostosis involving bones of the lower limbs (HP:0009138)2.56550141
62Abnormality of the corticospinal tract (HP:0002492)2.56499528
63Muscle fiber inclusion bodies (HP:0100299)2.55955657
64Nemaline bodies (HP:0003798)2.54996153
65Hyporeflexia of lower limbs (HP:0002600)2.53830142
66Neurofibrillary tangles (HP:0002185)2.52897469
67Stridor (HP:0010307)2.51896762
68Mesangial abnormality (HP:0001966)2.50333165
69Hypoplastic pelvis (HP:0008839)2.49316671
70Skull defect (HP:0001362)2.47197892
71Lissencephaly (HP:0001339)2.46145418
72Abnormality of the salivary glands (HP:0010286)2.45801784
73Achilles tendon contracture (HP:0001771)2.39249492
74Peripheral hypomyelination (HP:0007182)2.38763907
75Hemiplegia (HP:0002301)2.38318655
76Infantile muscular hypotonia (HP:0008947)2.37439579
77Fused cervical vertebrae (HP:0002949)2.37284745
78Difficulty running (HP:0009046)2.35790754
79Neonatal short-limb short stature (HP:0008921)2.34113758
80Neuroendocrine neoplasm (HP:0100634)2.31994094
81Scapular winging (HP:0003691)2.30795414
82Aplasia involving bones of the upper limbs (HP:0009823)2.30310285
83Aplasia of the phalanges of the hand (HP:0009802)2.30310285
84Aplasia involving bones of the extremities (HP:0009825)2.30310285
85Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.28191728
86Rib fusion (HP:0000902)2.27967790
87Absent radius (HP:0003974)2.27848621
88Shoulder girdle muscle weakness (HP:0003547)2.26898247
89Pheochromocytoma (HP:0002666)2.26487926
90Abnormality of the fetal cardiovascular system (HP:0010948)2.26354826
91Abnormal umbilical cord blood vessels (HP:0011403)2.26354826
92Single umbilical artery (HP:0001195)2.26354826
93Abnormality of the umbilical cord (HP:0010881)2.26199097
94Prominent occiput (HP:0000269)2.25910006
95Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.25833200
96Scotoma (HP:0000575)2.25383606
97Symphalangism affecting the phalanges of the hand (HP:0009773)2.25226586
98Ulnar deviation of finger (HP:0009465)2.24736298
99Axonal loss (HP:0003447)2.24565273
100Scrotal hypoplasia (HP:0000046)2.23917744
101Trismus (HP:0000211)2.22092289
102Breast hypoplasia (HP:0003187)2.21165945
103Abnormal auditory evoked potentials (HP:0006958)2.20187986
104Barrel-shaped chest (HP:0001552)2.19781584
105Duplication of thumb phalanx (HP:0009942)2.19367380
106Patellar aplasia (HP:0006443)2.19122633
107Absent forearm bone (HP:0003953)2.18562404
108Aplasia involving forearm bones (HP:0009822)2.18562404
109Adrenal hypoplasia (HP:0000835)2.17292468
110Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.16321161
111Abnormality of the Achilles tendon (HP:0005109)2.13808147
112Onion bulb formation (HP:0003383)2.13650707
113Broad nasal tip (HP:0000455)2.12437162
114Aplasia/hypoplasia of the femur (HP:0005613)2.10318092
115Abnormality of dentin (HP:0010299)2.10233201
116Hyperglycinuria (HP:0003108)2.10206657
117Decreased lacrimation (HP:0000633)2.09121189
118Genetic anticipation (HP:0003743)2.08427021
119Pelvic girdle muscle weakness (HP:0003749)2.07365557
120Increased serum pyruvate (HP:0003542)2.07111202
121Abnormality of glycolysis (HP:0004366)2.07111202
122Abnormality of the fibula (HP:0002991)2.06905049
123Large for gestational age (HP:0001520)2.04821643
124Spinal rigidity (HP:0003306)2.04490268
125Cerebral inclusion bodies (HP:0100314)2.04410183
126Large earlobe (HP:0009748)2.04267950
127Duplicated collecting system (HP:0000081)2.02853162
128Stenosis of the external auditory canal (HP:0000402)2.02277572
129Duodenal stenosis (HP:0100867)2.01571919
130Small intestinal stenosis (HP:0012848)2.01571919
131Hemivertebrae (HP:0002937)2.00544769
132Chin dimple (HP:0010751)2.00064216
133Broad metatarsal (HP:0001783)1.99198011
134Increased connective tissue (HP:0009025)1.99025606
135Delayed gross motor development (HP:0002194)1.97277394
136Centrally nucleated skeletal muscle fibers (HP:0003687)1.97208109
137Aplasia/Hypoplasia of the patella (HP:0006498)1.96651514
138Asplenia (HP:0001746)1.96612725
139Intellectual disability, profound (HP:0002187)1.95702606
140Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.94187775
141Abnormality of abdominal situs (HP:0011620)1.93416771
142Abdominal situs inversus (HP:0003363)1.93416771
143Pancreatic cysts (HP:0001737)1.91604155
144Poikiloderma (HP:0001029)1.91321719
145Selective tooth agenesis (HP:0001592)1.88598514
146Vertebral clefting (HP:0008428)1.88129937
147Anteriorly placed anus (HP:0001545)1.88079786
148Peritonitis (HP:0002586)1.87928499
149Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.87575597
150Bicornuate uterus (HP:0000813)1.85721967
151Hypoplasia of the radius (HP:0002984)1.85468635
152Type 1 muscle fiber predominance (HP:0003803)1.84699032
153Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.84306905
154Vertebral hypoplasia (HP:0008417)1.84306905
155Abnormality of skeletal muscle fiber size (HP:0012084)1.83544907
156Abnormality of binocular vision (HP:0011514)1.83069421
157Diplopia (HP:0000651)1.83069421
158Aplasia/Hypoplasia of the spleen (HP:0010451)1.82026297
159Bronchomalacia (HP:0002780)1.81713763
160EMG: myopathic abnormalities (HP:0003458)1.81530534
161Absent hand (HP:0004050)1.81491403
162Pterygium (HP:0001059)1.81072205
163Abnormality of the wing of the ilium (HP:0011867)1.80435314
164Increased variability in muscle fiber diameter (HP:0003557)1.79951980
165Impulsivity (HP:0100710)1.78532550
166Abnormal vertebral ossification (HP:0100569)1.78234249
167Difficulty climbing stairs (HP:0003551)1.77744985
168Recurrent corneal erosions (HP:0000495)1.77297718
169Cystic liver disease (HP:0006706)1.77212646
170Deformed tarsal bones (HP:0008119)1.77100556
171Abnormality of the middle phalanges of the toes (HP:0010183)1.76633054
172Bilateral microphthalmos (HP:0007633)1.76334488
173Absent septum pellucidum (HP:0001331)1.76262709
174Gastrointestinal atresia (HP:0002589)1.76010831
175Calcaneovalgus deformity (HP:0001848)1.75988764
176Ankle contracture (HP:0006466)1.75820323
177Supernumerary ribs (HP:0005815)1.75198935
178Hypoplasia of the capital femoral epiphysis (HP:0003090)1.74256693
179Postural instability (HP:0002172)1.73362371
180Abnormality of midbrain morphology (HP:0002418)1.72543094
181Ependymoma (HP:0002888)1.69950958
182Abnormality of the shoulder girdle musculature (HP:0001435)1.68758164
183Wormian bones (HP:0002645)1.68632857
184Abnormality of the calcaneus (HP:0008364)1.68623660
185Overriding aorta (HP:0002623)1.67708330
186Abnormality of the antihelix (HP:0009738)1.67705855
187Bladder diverticulum (HP:0000015)1.67200948
188Preaxial foot polydactyly (HP:0001841)1.67198932
189Ileus (HP:0002595)1.66670493
190Small epiphyses (HP:0010585)1.65368580
191Supernumerary bones of the axial skeleton (HP:0009144)1.64813098
192Bowed forearm bones (HP:0003956)1.63157283
193Bowing of the arm (HP:0006488)1.63157283
194Abnormality of the renal collecting system (HP:0004742)1.62809503

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK159.36400303
2TSSK66.16129775
3STK394.68077360
4ICK3.58024501
5EPHB13.47192143
6OXSR13.02692632
7BUB12.68155245
8MET2.39368200
9CDK122.38820208
10TESK22.20083133
11TYRO32.17704884
12LIMK12.15127308
13WNK12.07331780
14CDK192.06498396
15BCR1.97189626
16GRK11.79598657
17TTN1.79152468
18CLK11.78245415
19TAOK31.67627813
20NTRK31.66178203
21STK101.62127190
22ROCK21.60813777
23BMPR1B1.56406353
24MAP3K101.55817515
25WNK41.51608680
26EPHA21.49267285
27DDR21.48900715
28PBK1.46809880
29TTK1.43601590
30MOS1.39817150
31UHMK11.39560920
32PAK41.38309611
33TGFBR11.35607339
34VRK11.34012841
35PNCK1.32215288
36PINK11.30011872
37PKN11.29444215
38FGFR21.22414869
39BMX1.22350884
40PAK61.20403449
41LATS21.20272800
42MELK1.19508618
43CDK31.18427722
44PAK21.12571440
45MAPKAPK31.07539238
46MKNK21.06051307
47SIK11.04955817
48FGR1.04830490
49PAK11.04196348
50CDC71.04165520
51CSNK1A1L1.04126823
52TNK21.03764329
53CSNK1G31.01568367
54PASK1.00694452
55MAP3K21.00053919
56MTOR0.99341426
57IRAK30.98216326
58PRPF4B0.97706371
59MAP3K70.95955075
60AKT30.95824097
61ADRBK20.95483765
62CDK70.94969166
63IRAK10.94933532
64ALK0.93992042
65PAK30.92424207
66NEK20.92420489
67MARK20.90025812
68MAP3K80.87271985
69PTK20.86952291
70CDK140.86772295
71MAP2K20.86123961
72TAOK10.82956617
73EEF2K0.82342085
74TRPM70.81523433
75PDGFRB0.79921345
76CAMKK20.79584785
77CDK150.79388346
78NTRK20.79083924
79CHEK10.77710745
80CDK80.76732208
81CDK11A0.76323555
82DMPK0.75441180
83DYRK1A0.74876181
84CHEK20.72141093
85PTK2B0.70585355
86CDK180.68425992
87RPS6KB20.68338851
88CSNK1G10.66747631
89ERBB20.65838449
90TLK10.65257838
91PRKD10.65136569
92NTRK10.65009768
93TNIK0.64815698
94TRIB30.64524730
95STK40.64128136
96BRD40.63730814
97MST40.62921903
98FGFR10.60770496
99KSR20.60487993
100LATS10.59647724
101PDGFRA0.58909514
102IRAK40.58265310
103PRKCI0.57877575
104AURKA0.57133188
105BMPR20.57115343
106CHUK0.56849933
107CSNK1D0.56492816
108DYRK20.56099983
109MAPKAPK50.55264349
110EPHB20.54732869
111MKNK10.53929169
112ERN10.51752856
113ERBB40.50510144
114ADRBK10.50123170
115MAPK70.49869156
116STK30.49674509
117IRAK20.49151508
118RPS6KA50.48980842
119NEK60.48930579
120MAP4K10.47901042
121ROCK10.45900719
122PLK10.45774730
123CSK0.45096335
124DYRK30.45063857
125ILK0.44855482
126CAMK1D0.43801889
127OBSCN0.43607319
128CAMK2D0.43485521
129CDK40.43365171
130IKBKB0.43284616
131WEE10.42304713
132INSR0.41560891
133ITK0.39645537
134AKT20.38639139
135CSF1R0.38229897
136PRKD20.38136300
137CDK20.37829100
138MAPKAPK20.37229069
139CAMKK10.35413411
140GSK3A0.34378781
141PRKCG0.33914714
142PTK60.33376347
143KIT0.32589687
144MAPK100.32453317
145MAP3K110.31583964
146CDC42BPA0.31281266
147MAP3K10.31114348
148BRSK10.31064839
149NME10.30960429
150SGK10.30857126
151MATK0.29830033
152MAP3K40.28406736
153MAP2K40.27571627
154PRKCZ0.26910207
155PRKCQ0.24485307
156MAP2K10.22177616
157STK38L0.21636038
158RPS6KA10.18367450
159IKBKE0.17053160
160RPS6KA60.16882388
161CDK90.16284337
162DYRK1B0.15020836
163TBK10.14652791
164SGK2230.14428744
165SGK4940.14428744
166STK240.13801556
167AKT10.12798229
168MAPK130.11465074
169SIK20.11207679

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.55029691
2Steroid biosynthesis_Homo sapiens_hsa001003.56790449
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.36672692
4Fatty acid biosynthesis_Homo sapiens_hsa000613.36320297
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.08994697
6Fatty acid elongation_Homo sapiens_hsa000622.69190745
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.69119172
8Cocaine addiction_Homo sapiens_hsa050302.48776881
9Nitrogen metabolism_Homo sapiens_hsa009102.41022900
10Vitamin B6 metabolism_Homo sapiens_hsa007502.35314910
11Phototransduction_Homo sapiens_hsa047442.24448272
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.23515232
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21130440
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.14865177
15Ether lipid metabolism_Homo sapiens_hsa005652.10570025
16Spliceosome_Homo sapiens_hsa030402.08342864
17Prion diseases_Homo sapiens_hsa050201.93147511
18RNA polymerase_Homo sapiens_hsa030201.86566129
19Basal cell carcinoma_Homo sapiens_hsa052171.85775190
20Basal transcription factors_Homo sapiens_hsa030221.85487713
21* Tight junction_Homo sapiens_hsa045301.77377578
22Hedgehog signaling pathway_Homo sapiens_hsa043401.75655910
23Notch signaling pathway_Homo sapiens_hsa043301.74654856
24Axon guidance_Homo sapiens_hsa043601.72305774
25Cell cycle_Homo sapiens_hsa041101.70602558
26Renal cell carcinoma_Homo sapiens_hsa052111.67037546
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.66815198
28Amphetamine addiction_Homo sapiens_hsa050311.66627326
29DNA replication_Homo sapiens_hsa030301.66133770
30RNA transport_Homo sapiens_hsa030131.65263742
31ECM-receptor interaction_Homo sapiens_hsa045121.65160028
32Estrogen signaling pathway_Homo sapiens_hsa049151.64033746
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.63928351
34Hippo signaling pathway_Homo sapiens_hsa043901.63780754
35MicroRNAs in cancer_Homo sapiens_hsa052061.48328547
36mRNA surveillance pathway_Homo sapiens_hsa030151.41558113
37Calcium signaling pathway_Homo sapiens_hsa040201.40746885
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32069029
39Regulation of actin cytoskeleton_Homo sapiens_hsa048101.29872518
40Bladder cancer_Homo sapiens_hsa052191.26753089
41Ribosome_Homo sapiens_hsa030101.26443522
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26048954
43Focal adhesion_Homo sapiens_hsa045101.24210932
44Morphine addiction_Homo sapiens_hsa050321.22154473
45Small cell lung cancer_Homo sapiens_hsa052221.22051223
46Non-homologous end-joining_Homo sapiens_hsa034501.20556705
47Insulin secretion_Homo sapiens_hsa049111.19668606
48Mismatch repair_Homo sapiens_hsa034301.19590546
49Nucleotide excision repair_Homo sapiens_hsa034201.17151990
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16974454
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16320979
52Melanogenesis_Homo sapiens_hsa049161.15180309
53Proteoglycans in cancer_Homo sapiens_hsa052051.11774006
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10346365
55Homologous recombination_Homo sapiens_hsa034401.07863409
56TNF signaling pathway_Homo sapiens_hsa046681.07263652
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06519023
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.06302062
59Linoleic acid metabolism_Homo sapiens_hsa005911.06014562
60Dorso-ventral axis formation_Homo sapiens_hsa043201.05590627
61Ovarian steroidogenesis_Homo sapiens_hsa049131.04501628
62PI3K-Akt signaling pathway_Homo sapiens_hsa041511.04097587
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.03169014
64Base excision repair_Homo sapiens_hsa034101.02353333
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02283928
66GnRH signaling pathway_Homo sapiens_hsa049121.01797137
67Sphingolipid metabolism_Homo sapiens_hsa006001.00460297
68TGF-beta signaling pathway_Homo sapiens_hsa043501.00199691
69cAMP signaling pathway_Homo sapiens_hsa040240.99127003
70Protein export_Homo sapiens_hsa030600.98635104
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98169586
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97175495
73Proteasome_Homo sapiens_hsa030500.96139332
74Endocytosis_Homo sapiens_hsa041440.95323053
75RNA degradation_Homo sapiens_hsa030180.94296218
76Arginine and proline metabolism_Homo sapiens_hsa003300.94135921
77Viral carcinogenesis_Homo sapiens_hsa052030.92789626
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92763875
79Shigellosis_Homo sapiens_hsa051310.92762184
80Pathways in cancer_Homo sapiens_hsa052000.90489570
81Chronic myeloid leukemia_Homo sapiens_hsa052200.90358147
82Dilated cardiomyopathy_Homo sapiens_hsa054140.89677930
83Pertussis_Homo sapiens_hsa051330.89593981
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88626863
85p53 signaling pathway_Homo sapiens_hsa041150.88545456
86Histidine metabolism_Homo sapiens_hsa003400.88292745
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88187252
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87611370
89Glutathione metabolism_Homo sapiens_hsa004800.87196654
90Prostate cancer_Homo sapiens_hsa052150.86460275
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.86010570
92Legionellosis_Homo sapiens_hsa051340.85615949
93Antigen processing and presentation_Homo sapiens_hsa046120.83275738
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.82672133
95ABC transporters_Homo sapiens_hsa020100.80678451
96Wnt signaling pathway_Homo sapiens_hsa043100.80243354
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79709909
98Vitamin digestion and absorption_Homo sapiens_hsa049770.79386802
99Adherens junction_Homo sapiens_hsa045200.78688093
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78088391
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.76783147
102Toxoplasmosis_Homo sapiens_hsa051450.76103120
103HTLV-I infection_Homo sapiens_hsa051660.75820007
104Dopaminergic synapse_Homo sapiens_hsa047280.75352370
105Complement and coagulation cascades_Homo sapiens_hsa046100.75341887
106Fanconi anemia pathway_Homo sapiens_hsa034600.73186939
107Epstein-Barr virus infection_Homo sapiens_hsa051690.71697481
108Taste transduction_Homo sapiens_hsa047420.69476515
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.68882665
110Pancreatic cancer_Homo sapiens_hsa052120.68047464
111Leishmaniasis_Homo sapiens_hsa051400.67449451
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66351174
113Ras signaling pathway_Homo sapiens_hsa040140.65986998
114Oxytocin signaling pathway_Homo sapiens_hsa049210.65555459
115Sulfur relay system_Homo sapiens_hsa041220.63950915
116ErbB signaling pathway_Homo sapiens_hsa040120.62907026
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62822232
118Salivary secretion_Homo sapiens_hsa049700.62734401
119Circadian entrainment_Homo sapiens_hsa047130.62473188
120Tryptophan metabolism_Homo sapiens_hsa003800.61046131
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60683645
122Malaria_Homo sapiens_hsa051440.60677968
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60494612
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59674752
125Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59612212
126Viral myocarditis_Homo sapiens_hsa054160.57564500
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56898786
128Osteoclast differentiation_Homo sapiens_hsa043800.55051534
129Glutamatergic synapse_Homo sapiens_hsa047240.55008207
130African trypanosomiasis_Homo sapiens_hsa051430.54757719
131Cholinergic synapse_Homo sapiens_hsa047250.54503176
132Bile secretion_Homo sapiens_hsa049760.53331502
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53085671
134Choline metabolism in cancer_Homo sapiens_hsa052310.52058461
135Hepatitis B_Homo sapiens_hsa051610.51877466
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51680880
137Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51223982
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51133161
139Gastric acid secretion_Homo sapiens_hsa049710.51084347
140Salmonella infection_Homo sapiens_hsa051320.51027300
141MAPK signaling pathway_Homo sapiens_hsa040100.50615419
142Arachidonic acid metabolism_Homo sapiens_hsa005900.50398980
143Folate biosynthesis_Homo sapiens_hsa007900.49899446
144Lysine degradation_Homo sapiens_hsa003100.49250801
145Oocyte meiosis_Homo sapiens_hsa041140.49213465
146VEGF signaling pathway_Homo sapiens_hsa043700.48820420
147Protein digestion and absorption_Homo sapiens_hsa049740.48683046
148Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47366275
149Type II diabetes mellitus_Homo sapiens_hsa049300.46105360
150B cell receptor signaling pathway_Homo sapiens_hsa046620.45091387
151Influenza A_Homo sapiens_hsa051640.44039865
152Non-small cell lung cancer_Homo sapiens_hsa052230.43907077
153Rap1 signaling pathway_Homo sapiens_hsa040150.43477213
154T cell receptor signaling pathway_Homo sapiens_hsa046600.43422189
155Acute myeloid leukemia_Homo sapiens_hsa052210.43415127
156Long-term depression_Homo sapiens_hsa047300.43368201
157Cardiac muscle contraction_Homo sapiens_hsa042600.42789508
158Neurotrophin signaling pathway_Homo sapiens_hsa047220.42695763
159PPAR signaling pathway_Homo sapiens_hsa033200.42071387
160Nicotine addiction_Homo sapiens_hsa050330.41586046
161Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40877759
162GABAergic synapse_Homo sapiens_hsa047270.39468169
163Amoebiasis_Homo sapiens_hsa051460.39125350
164Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38752347
165Colorectal cancer_Homo sapiens_hsa052100.38137632
166Central carbon metabolism in cancer_Homo sapiens_hsa052300.37717155
167Apoptosis_Homo sapiens_hsa042100.36584998
168Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36249562
169Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34103962
170One carbon pool by folate_Homo sapiens_hsa006700.34022185
171Pyrimidine metabolism_Homo sapiens_hsa002400.33835609
172Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33465209
173Glycerophospholipid metabolism_Homo sapiens_hsa005640.30223762

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »