TJP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vascular endothelial growth factor signaling pathway (GO:0038084)3.74329273
2lymphangiogenesis (GO:0001946)3.62781498
3lymph vessel development (GO:0001945)3.58767263
4* hippo signaling (GO:0035329)3.48609415
5desmosome organization (GO:0002934)3.48042419
6renal filtration (GO:0097205)3.43425412
7glomerular basement membrane development (GO:0032836)3.37221401
8retina vasculature morphogenesis in camera-type eye (GO:0061299)3.36031102
9paraxial mesoderm development (GO:0048339)3.32123360
10cell migration involved in sprouting angiogenesis (GO:0002042)3.32101889
11cytoskeletal anchoring at plasma membrane (GO:0007016)3.27233385
12insulin-like growth factor receptor signaling pathway (GO:0048009)3.12945811
13glomerular visceral epithelial cell development (GO:0072015)3.11992314
14embryonic foregut morphogenesis (GO:0048617)3.11527762
15regulation of transforming growth factor beta2 production (GO:0032909)3.10860747
16polarized epithelial cell differentiation (GO:0030859)3.08859632
17hemidesmosome assembly (GO:0031581)3.03083171
18basement membrane organization (GO:0071711)2.99240975
19regulation of hippo signaling (GO:0035330)2.91828097
20glomerular epithelial cell development (GO:0072310)2.88818047
21epithelial cell-cell adhesion (GO:0090136)2.88644234
22cell adhesion mediated by integrin (GO:0033627)2.87103274
23negative regulation of keratinocyte proliferation (GO:0010839)2.86016997
24regulation of cardioblast differentiation (GO:0051890)2.84542167
25protein localization to endosome (GO:0036010)2.83761752
26artery development (GO:0060840)2.83644767
27adherens junction assembly (GO:0034333)2.82568820
28cytoplasmic mRNA processing body assembly (GO:0033962)2.82038591
29glomerular filtration (GO:0003094)2.81846689
30coronary vasculature morphogenesis (GO:0060977)2.79069252
31cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.74937045
32anterior/posterior axis specification, embryo (GO:0008595)2.74140824
33surfactant homeostasis (GO:0043129)2.74130397
34positive regulation of hormone biosynthetic process (GO:0046886)2.73009603
35endothelial cell morphogenesis (GO:0001886)2.70938531
36establishment of apical/basal cell polarity (GO:0035089)2.69293514
37plasma membrane repair (GO:0001778)2.69203884
38blood vessel endothelial cell migration (GO:0043534)2.68153017
39endocardial cushion development (GO:0003197)2.67814021
40dorsal/ventral axis specification (GO:0009950)2.67061883
41heart morphogenesis (GO:0003007)2.66683029
42renal system development (GO:0072001)2.64894602
43regulation of SMAD protein import into nucleus (GO:0060390)2.64057561
44stress fiber assembly (GO:0043149)2.63373138
45positive regulation of SMAD protein import into nucleus (GO:0060391)2.60967091
46dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.59681471
47branching involved in salivary gland morphogenesis (GO:0060445)2.59618534
48mesodermal cell differentiation (GO:0048333)2.56997092
49patterning of blood vessels (GO:0001569)2.55209917
50regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.54678619
51nuclear pore complex assembly (GO:0051292)2.54121187
52vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.53534905
53peptidyl-tyrosine autophosphorylation (GO:0038083)2.53240205
54regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.51908608
55cell-substrate junction assembly (GO:0007044)2.50422274
56mitotic sister chromatid cohesion (GO:0007064)2.50235125
57establishment of nucleus localization (GO:0040023)2.50227060
58NLS-bearing protein import into nucleus (GO:0006607)2.49394121
59regulation of cell fate specification (GO:0042659)2.47286487
60bundle of His cell to Purkinje myocyte communication (GO:0086069)2.45226690
61positive regulation of catenin import into nucleus (GO:0035413)2.44947042
62establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.44829081
63negative regulation of catenin import into nucleus (GO:0035414)2.44526547
64embryonic heart tube development (GO:0035050)2.43510552
65chondrocyte proliferation (GO:0035988)2.43432659
66negative regulation of cell fate specification (GO:0009996)2.42206081
67embryonic retina morphogenesis in camera-type eye (GO:0060059)2.41606124
68apical protein localization (GO:0045176)2.40916425
69substrate adhesion-dependent cell spreading (GO:0034446)2.38872602
70gastrulation with mouth forming second (GO:0001702)2.38538977
71axon extension involved in axon guidance (GO:0048846)2.37545612
72neuron projection extension involved in neuron projection guidance (GO:1902284)2.37545612
73cardiac myofibril assembly (GO:0055003)2.36087374
74blood vessel maturation (GO:0001955)2.34972560
75morphogenesis of an epithelial sheet (GO:0002011)2.34266651
76regulation of catenin import into nucleus (GO:0035412)2.33966445
77pre-miRNA processing (GO:0031054)2.33535890
78vasculogenesis (GO:0001570)2.32040024
79regulation of tight junction assembly (GO:2000810)2.31906781
80cell communication involved in cardiac conduction (GO:0086065)2.31694974
81regulation of axon extension involved in axon guidance (GO:0048841)2.30731936
82chemical homeostasis within a tissue (GO:0048875)2.30344976
83negative regulation of Rho protein signal transduction (GO:0035024)2.30240099
84regulation of p38MAPK cascade (GO:1900744)2.28606265
85regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.28562256
86negative regulation of chondrocyte differentiation (GO:0032331)2.28077883
87gap junction assembly (GO:0016264)2.27679140
88cell-substrate adherens junction assembly (GO:0007045)2.26733299
89focal adhesion assembly (GO:0048041)2.26733299
90cell communication by electrical coupling (GO:0010644)2.26531106
91nuclear pore organization (GO:0006999)2.26489627
92peripheral nervous system axon ensheathment (GO:0032292)2.26452214
93myelination in peripheral nervous system (GO:0022011)2.26452214
94endothelium development (GO:0003158)2.26364835
95regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.26352306
96positive regulation of p38MAPK cascade (GO:1900745)2.23782618
97adherens junction organization (GO:0034332)2.23260491
98lung vasculature development (GO:0060426)2.23057963
99* cell-cell junction assembly (GO:0007043)2.22799280
100regulation of keratinocyte proliferation (GO:0010837)2.22309427
101camera-type eye morphogenesis (GO:0048593)2.21627337
102intestinal epithelial cell development (GO:0060576)2.21336171
103asymmetric protein localization (GO:0008105)2.21288207
104notochord development (GO:0030903)2.21224633
105venous blood vessel morphogenesis (GO:0048845)2.21141301
106cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.19218701
107midgut development (GO:0007494)2.19059772
108regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.18945558
109prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.18784660
110branching involved in prostate gland morphogenesis (GO:0060442)2.18758508
111establishment or maintenance of monopolar cell polarity (GO:0061339)2.18049100
112establishment of monopolar cell polarity (GO:0061162)2.18049100
113semaphorin-plexin signaling pathway (GO:0071526)2.15599986
114skin morphogenesis (GO:0043589)2.15397979
115planar cell polarity pathway involved in neural tube closure (GO:0090179)2.14815746
116negative regulation of DNA repair (GO:0045738)2.14219129
117platelet-derived growth factor receptor signaling pathway (GO:0048008)2.13626060
118blood vessel morphogenesis (GO:0048514)2.13385561
119ventricular cardiac muscle cell development (GO:0055015)2.13369629
120ectodermal placode formation (GO:0060788)2.13359559
121apoptotic cell clearance (GO:0043277)2.12917147
122glomerulus development (GO:0032835)2.12556086
123cell surface receptor signaling pathway involved in heart development (GO:0061311)2.11376136
124tight junction assembly (GO:0070830)2.07197219
125Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.04998809
126protein localization to cell surface (GO:0034394)2.04615297
127establishment of planar polarity (GO:0001736)2.04467293
128establishment of tissue polarity (GO:0007164)2.04467293
129cellular protein complex localization (GO:0034629)2.04305925
130establishment or maintenance of bipolar cell polarity (GO:0061245)2.03454419
131establishment or maintenance of apical/basal cell polarity (GO:0035088)2.03454419
132regulation of establishment of planar polarity (GO:0090175)2.02660730
133convergent extension (GO:0060026)2.01235608
134protein complex localization (GO:0031503)1.97581595
135lateral sprouting from an epithelium (GO:0060601)1.96073865
136non-canonical Wnt signaling pathway (GO:0035567)1.94683215
137membrane assembly (GO:0071709)1.94301816
138* cell junction assembly (GO:0034329)1.94237350
139regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)1.93545022
140regulation of vascular endothelial growth factor signaling pathway (GO:1900746)1.93489705
141lung lobe morphogenesis (GO:0060463)1.92948938
142genitalia morphogenesis (GO:0035112)1.91609122
143negative regulation of hormone biosynthetic process (GO:0032353)1.91257333
144mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)1.89307249
145collagen fibril organization (GO:0030199)1.89158356
146embryonic camera-type eye morphogenesis (GO:0048596)1.88810803
147mitotic cytokinesis (GO:0000281)1.88514037
148regulation of gene silencing by miRNA (GO:0060964)1.87390317

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.17433896
2AR_21909140_ChIP-Seq_LNCAP_Human2.97454699
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.77486727
4* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.37233123
5CLOCK_20551151_ChIP-Seq_293T_Human2.27595154
6SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.17261140
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.15116179
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.11139796
9* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.05636524
10EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.98579767
11ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.96878484
12ESR2_21235772_ChIP-Seq_MCF-7_Human1.86482625
13TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.85743449
14STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82580119
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.81323693
16WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.80930717
17GBX2_23144817_ChIP-Seq_PC3_Human1.80141080
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.79137464
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.77214740
20FOXO3_23340844_ChIP-Seq_DLD1_Human1.69909547
21ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.67069280
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65928084
23ISL1_27105846_Chip-Seq_CPCs_Mouse1.64576043
24SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.61588069
25WT1_19549856_ChIP-ChIP_CCG9911_Human1.61022619
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60975491
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.60975291
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.60975291
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.60975291
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.59156114
31DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.57464245
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52754504
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52736359
34AHR_22903824_ChIP-Seq_MCF-7_Human1.52427421
35PPAR_26484153_Chip-Seq_NCI-H1993_Human1.51806126
36SALL4_18804426_ChIP-ChIP_XEN_Mouse1.50433372
37TCF4_18268006_ChIP-ChIP_LS174T_Human1.49956994
38TP53_16413492_ChIP-PET_HCT116_Human1.49825101
39* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.49626989
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47755356
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46626216
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.45723932
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44556401
44ZNF263_19887448_ChIP-Seq_K562_Human1.43722646
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43610869
46* ESR1_20079471_ChIP-ChIP_T-47D_Human1.40377188
47FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.40288752
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39780502
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38638876
50* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37848014
51SMAD4_21799915_ChIP-Seq_A2780_Human1.36868061
52SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36775020
53ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36046267
54* FOXA2_19822575_ChIP-Seq_HepG2_Human1.34787326
55TBX20_22328084_ChIP-Seq_HEART_Mouse1.34116490
56TBX20_22080862_ChIP-Seq_HEART_Mouse1.34116490
57* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32895369
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32894638
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32894638
60NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32458937
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.31552479
62CJUN_26792858_Chip-Seq_BT549_Human1.30979396
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.30546181
64* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30349881
65KDM2B_26808549_Chip-Seq_K562_Human1.29939871
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29513714
67ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26914966
68BRD4_25478319_ChIP-Seq_HGPS_Human1.26264397
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25881919
70* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22625541
71TP53_18474530_ChIP-ChIP_U2OS_Human1.22313055
72EGR1_19374776_ChIP-ChIP_THP-1_Human1.22026412
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.21748497
74* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20899418
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19572509
76FOXM1_23109430_ChIP-Seq_U2OS_Human1.18376535
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17435499
78* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17105079
79E2F7_22180533_ChIP-Seq_HELA_Human1.16825717
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16402132
81P300_19829295_ChIP-Seq_ESCs_Human1.14882970
82FUS_26573619_Chip-Seq_HEK293_Human1.14714307
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14414051
84* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13044627
85TBX3_20139965_ChIP-Seq_MESCs_Mouse1.12904633
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12430697
87TBX3_20139965_ChIP-Seq_ESCs_Mouse1.12410947
88POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11679676
89* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11633193
90SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10720477
91* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09774510
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09387134
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08606982
94RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08180069
95* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07092662
96* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07092662
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07057988
98TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06638869
99SMAD3_21741376_ChIP-Seq_HESCs_Human1.06130380
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06009972
101RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05013400
102EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05013400
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.04258886
104TAF15_26573619_Chip-Seq_HEK293_Human1.04238178
105SOX9_26525672_Chip-Seq_HEART_Mouse1.03846121
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03490100
107* RUNX1_27514584_Chip-Seq_MCF-7_Human1.03484527
108NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.03202568
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03175453
110PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02918917
111SMAD_19615063_ChIP-ChIP_OVARY_Human1.02839904
112PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01998980
113* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01187249
114SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00785598
115RING1B_27294783_Chip-Seq_NPCs_Mouse1.00199168
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00191711
117* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.99765921
118FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99720824
119* STAT3_23295773_ChIP-Seq_U87_Human0.99576412
120TCF3_18692474_ChIP-Seq_MESCs_Mouse0.99255583
121* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98799058
122ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98789325
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98728961
124* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98541452
125AR_21572438_ChIP-Seq_LNCaP_Human0.98468499
126SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98373558
127RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98265975
128EED_16625203_ChIP-ChIP_MESCs_Mouse0.97844497
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.97664027
130CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97530756
131DROSHA_22980978_ChIP-Seq_HELA_Human0.96341983
132EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94863511
133ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94337070

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane3.80343679
2MP0010368_abnormal_lymphatic_system3.30639586
3MP0003705_abnormal_hypodermis_morpholog3.24475357
4MP0005623_abnormal_meninges_morphology3.01831621
5MP0000537_abnormal_urethra_morphology2.71324165
6MP0010234_abnormal_vibrissa_follicle2.50745214
7MP0001879_abnormal_lymphatic_vessel2.43683466
8MP0004084_abnormal_cardiac_muscle2.30125300
9MP0005167_abnormal_blood-brain_barrier2.09124544
10MP0003283_abnormal_digestive_organ1.89793097
11MP0008438_abnormal_cutaneous_collagen1.86386751
12MP0003566_abnormal_cell_adhesion1.84701516
13MP0009780_abnormal_chondrocyte_physiolo1.84683791
14MP0009384_cardiac_valve_regurgitation1.81974327
15MP0000579_abnormal_nail_morphology1.68079776
16MP0010352_gastrointestinal_tract_polyps1.67030671
17MP0003941_abnormal_skin_development1.64845759
18MP0009053_abnormal_anal_canal1.61259129
19MP0000534_abnormal_ureter_morphology1.58302457
20MP0006138_congestive_heart_failure1.58120819
21MP0010030_abnormal_orbit_morphology1.55921661
22MP0000566_synostosis1.53039574
23MP0005187_abnormal_penis_morphology1.51431637
24MP0005076_abnormal_cell_differentiation1.51100146
25MP0005275_abnormal_skin_tensile1.50713861
26MP0006054_spinal_hemorrhage1.50269564
27MP0000733_abnormal_muscle_development1.49246432
28MP0003115_abnormal_respiratory_system1.48757890
29MP0010678_abnormal_skin_adnexa1.48131882
30MP0002697_abnormal_eye_size1.40839640
31MP0004185_abnormal_adipocyte_glucose1.40564811
32MP0005248_abnormal_Harderian_gland1.40538993
33MP0003935_abnormal_craniofacial_develop1.40308707
34MP0002925_abnormal_cardiovascular_devel1.39249831
35MP0004233_abnormal_muscle_weight1.39166661
36MP0003385_abnormal_body_wall1.37348760
37MP0005367_renal/urinary_system_phenotyp1.36113249
38MP0000516_abnormal_urinary_system1.36113249
39MP0002796_impaired_skin_barrier1.34711582
40MP0004264_abnormal_extraembryonic_tissu1.34118092
41MP0003950_abnormal_plasma_membrane1.33142111
42MP0003091_abnormal_cell_migration1.33117131
43MP0010630_abnormal_cardiac_muscle1.31909651
44MP0003279_aneurysm1.31812116
45MP0003119_abnormal_digestive_system1.30004872
46MP0005257_abnormal_intraocular_pressure1.28238843
47MP0003937_abnormal_limbs/digits/tail_de1.28160470
48MP0001849_ear_inflammation1.25701813
49MP0003045_fibrosis1.24441137
50MP0000767_abnormal_smooth_muscle1.23963828
51MP0003300_gastrointestinal_ulcer1.22336655
52MP0002896_abnormal_bone_mineralization1.21978800
53MP0001958_emphysema1.21199333
54MP0004036_abnormal_muscle_relaxation1.18498774
55MP0002084_abnormal_developmental_patter1.17262100
56MP0008057_abnormal_DNA_replication1.16721414
57MP0005409_darkened_coat_color1.15659946
58MP0003122_maternal_imprinting1.15367576
59MP0001299_abnormal_eye_distance/1.14813842
60MP0004215_abnormal_myocardial_fiber1.14101788
61MP0002233_abnormal_nose_morphology1.13996783
62MP0003890_abnormal_embryonic-extraembry1.13891605
63MP0002086_abnormal_extraembryonic_tissu1.13499750
64MP0008775_abnormal_heart_ventricle1.11975502
65MP0000003_abnormal_adipose_tissue1.11458724
66MP0003942_abnormal_urinary_system1.10385095
67MP0000462_abnormal_digestive_system1.09482939
68MP0000428_abnormal_craniofacial_morphol1.09456720
69MP0001915_intracranial_hemorrhage1.08498593
70MP0004197_abnormal_fetal_growth/weight/1.08366451
71MP0003984_embryonic_growth_retardation1.07670597
72MP0005503_abnormal_tendon_morphology1.07336646
73MP0004270_analgesia1.07166588
74MP0002108_abnormal_muscle_morphology1.06234336
75MP0004087_abnormal_muscle_fiber1.06053223
76MP0002088_abnormal_embryonic_growth/wei1.05957015
77MP0002877_abnormal_melanocyte_morpholog1.05279837
78MP0002128_abnormal_blood_circulation1.05055986
79MP0009672_abnormal_birth_weight1.03750334
80MP0004858_abnormal_nervous_system1.03584018
81MP0002060_abnormal_skin_morphology1.02881792
82MP0009250_abnormal_appendicular_skeleto1.02860527
83MP0005666_abnormal_adipose_tissue1.01822141
84MP0001614_abnormal_blood_vessel1.00296898
85MP0000266_abnormal_heart_morphology1.00157265
86MP0000013_abnormal_adipose_tissue0.99739098
87MP0000751_myopathy0.99453895
88MP0001177_atelectasis0.98406463
89MP0000383_abnormal_hair_follicle0.98171168
90MP0002234_abnormal_pharynx_morphology0.98145149
91MP0001672_abnormal_embryogenesis/_devel0.98062974
92MP0005380_embryogenesis_phenotype0.98062974
93MP0005023_abnormal_wound_healing0.97749034
94MP0004885_abnormal_endolymph0.97465285
95MP0002085_abnormal_embryonic_tissue0.97276544
96MP0000432_abnormal_head_morphology0.96221995
97MP0005375_adipose_tissue_phenotype0.96087397
98MP0003567_abnormal_fetal_cardiomyocyte0.94035744
99MP0001784_abnormal_fluid_regulation0.91844898
100MP0003755_abnormal_palate_morphology0.91372449
101MP0004957_abnormal_blastocyst_morpholog0.90362891
102MP0003252_abnormal_bile_duct0.90318084
103MP0003828_pulmonary_edema0.89358846
104MP0002972_abnormal_cardiac_muscle0.88551095
105MP0001286_abnormal_eye_development0.86490114
106MP0004484_altered_response_of0.85900314
107MP0000762_abnormal_tongue_morphology0.85437084
108MP0001730_embryonic_growth_arrest0.85362211
109MP0003123_paternal_imprinting0.85270561
110MP0009703_decreased_birth_body0.84759316
111MP0005508_abnormal_skeleton_morphology0.84656439
112MP0002092_abnormal_eye_morphology0.84266991
113MP0004085_abnormal_heartbeat0.83597611
114MP0003121_genomic_imprinting0.83158992
115MP0005330_cardiomyopathy0.82744587
116MP0000467_abnormal_esophagus_morphology0.82537048
117MP0002009_preneoplasia0.82456215
118MP0002295_abnormal_pulmonary_circulatio0.82184430
119MP0002932_abnormal_joint_morphology0.81429336
120MP0002111_abnormal_tail_morphology0.81357985
121MP0005501_abnormal_skin_physiology0.80623414
122MP0001293_anophthalmia0.80372011
123MP0009697_abnormal_copulation0.80149329
124MP0003861_abnormal_nervous_system0.78560341
125MP0008932_abnormal_embryonic_tissue0.77668618
126MP0000647_abnormal_sebaceous_gland0.74683690
127MP0002116_abnormal_craniofacial_bone0.72883421
128MP0001661_extended_life_span0.71881697
129MP0000778_abnormal_nervous_system0.71339198

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)3.42624656
2Shallow orbits (HP:0000586)3.37675154
3Broad metatarsal (HP:0001783)2.90508289
4Right ventricular cardiomyopathy (HP:0011663)2.76272270
5Focal segmental glomerulosclerosis (HP:0000097)2.62640695
6Hypoplastic ischia (HP:0003175)2.60303247
7Protrusio acetabuli (HP:0003179)2.56416276
8Aortic aneurysm (HP:0004942)2.54578235
9Lymphangioma (HP:0100764)2.54170233
10Hematochezia (HP:0002573)2.44335030
11Aneurysm (HP:0002617)2.42847527
12Abnormality of the ischium (HP:0003174)2.36244631
13Atrophic scars (HP:0001075)2.34296584
14Ankle contracture (HP:0006466)2.29178032
15Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.26616992
16Hyporeflexia of lower limbs (HP:0002600)2.25292428
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.23935205
18Short 4th metacarpal (HP:0010044)2.23935205
19Vertebral arch anomaly (HP:0008438)2.22211283
20Rectal prolapse (HP:0002035)2.18944694
21Subacute progressive viral hepatitis (HP:0006572)2.16432228
22Mitral valve prolapse (HP:0001634)2.15562342
23Arterial tortuosity (HP:0005116)2.13807534
24Macroorchidism (HP:0000053)2.11718087
25Neonatal short-limb short stature (HP:0008921)2.09878631
26Premature rupture of membranes (HP:0001788)2.09708482
27Glomerulosclerosis (HP:0000096)2.07472945
28Skull defect (HP:0001362)2.07340954
29Aortic dissection (HP:0002647)2.03538492
30Bronchomalacia (HP:0002780)2.02999943
31Bladder diverticulum (HP:0000015)2.01974223
32Urethral obstruction (HP:0000796)2.00383243
33Vascular tortuosity (HP:0004948)1.99281514
34Absent eyelashes (HP:0000561)1.94856872
35Abnormality of the 4th metacarpal (HP:0010012)1.94745675
36Renal duplication (HP:0000075)1.94683832
37Buphthalmos (HP:0000557)1.93692781
38Esophageal varix (HP:0002040)1.92157583
39Advanced eruption of teeth (HP:0006288)1.88917517
40Broad thumb (HP:0011304)1.87533108
41Coronal craniosynostosis (HP:0004440)1.87262465
42Pterygium (HP:0001059)1.85944388
43Increased connective tissue (HP:0009025)1.84058773
44Overgrowth (HP:0001548)1.83953486
45Astrocytoma (HP:0009592)1.83692573
46Abnormality of the astrocytes (HP:0100707)1.83692573
47Difficulty running (HP:0009046)1.83384060
48Short hallux (HP:0010109)1.81211080
49Mildly elevated creatine phosphokinase (HP:0008180)1.78116383
50Shawl scrotum (HP:0000049)1.78101674
51Cutaneous finger syndactyly (HP:0010554)1.76345091
52Narrow palate (HP:0000189)1.76088995
53Esophageal atresia (HP:0002032)1.75847203
54Milia (HP:0001056)1.73088615
55Muscle fiber splitting (HP:0003555)1.72967870
56Gastrointestinal carcinoma (HP:0002672)1.72758983
57Malignant gastrointestinal tract tumors (HP:0006749)1.72758983
58Enlarged penis (HP:0000040)1.72352100
59Midline defect of the nose (HP:0004122)1.71322995
60Cutaneous syndactyly (HP:0012725)1.70424353
61Scapular winging (HP:0003691)1.69723541
62Osteolytic defects of the hand bones (HP:0009699)1.69216842
63Osteolytic defects of the phalanges of the hand (HP:0009771)1.69216842
64Turricephaly (HP:0000262)1.68906892
65Visceral angiomatosis (HP:0100761)1.68689398
66Trigonocephaly (HP:0000243)1.68235569
67Hip contracture (HP:0003273)1.67234621
68Wormian bones (HP:0002645)1.66558871
69Abnormality of the distal phalanx of the thumb (HP:0009617)1.65575590
70Abnormality of permanent molar morphology (HP:0011071)1.64884376
71Abnormality of the dental root (HP:0006486)1.64884376
72Taurodontia (HP:0000679)1.64884376
73Termporal pattern (HP:0011008)1.64460107
74Insidious onset (HP:0003587)1.64460107
75Abnormality of molar (HP:0011077)1.63322569
76Abnormality of molar morphology (HP:0011070)1.63322569
77Biliary tract neoplasm (HP:0100574)1.63214010
78Aplasia/Hypoplasia of the hallux (HP:0008362)1.63189049
79Hemangiomatosis (HP:0007461)1.62952661
80Ankyloglossia (HP:0010296)1.62142687
81Abnormality of the nasal septum (HP:0000419)1.61687062
82Upper limb amyotrophy (HP:0009129)1.61686118
83Distal upper limb amyotrophy (HP:0007149)1.61686118
84Selective tooth agenesis (HP:0001592)1.61637374
85Hypoplasia of the iris (HP:0007676)1.60679514
86Choanal stenosis (HP:0000452)1.60647035
87Hypoplastic labia majora (HP:0000059)1.60120263
88Back pain (HP:0003418)1.59253181
89Lip pit (HP:0100267)1.59070649
90Mesangial abnormality (HP:0001966)1.58781717
91Pulmonic stenosis (HP:0001642)1.56370944
92Arnold-Chiari malformation (HP:0002308)1.55885719
93Increased nuchal translucency (HP:0010880)1.55811881
94Renovascular hypertension (HP:0100817)1.55502991
95Abnormality of dentin (HP:0010299)1.55409541
96Spinal rigidity (HP:0003306)1.55356596
97Long eyelashes (HP:0000527)1.55179061
98Polycythemia (HP:0001901)1.55042731
99Short humerus (HP:0005792)1.54565249
100Disproportionate tall stature (HP:0001519)1.54101722
101Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.54000939
102Exostoses (HP:0100777)1.53964137
103Elfin facies (HP:0004428)1.53152908
104Soft skin (HP:0000977)1.52498249
105Omphalocele (HP:0001539)1.50965498
106Bowel diverticulosis (HP:0005222)1.50904404
107Vertebral clefting (HP:0008428)1.50891582
108Abnormality of the labia majora (HP:0012881)1.50821617
109Bundle branch block (HP:0011710)1.50365175
110Abnormality of the salivary glands (HP:0010286)1.50007155
111Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.49835061
112Absent hair (HP:0002298)1.49833994
113Hyperacusis (HP:0010780)1.49684447
114Germ cell neoplasia (HP:0100728)1.49295349
115Venous insufficiency (HP:0005293)1.49146920
116Deviation of the thumb (HP:0009603)1.48765628
117Preaxial foot polydactyly (HP:0001841)1.48728991
118Abnormality of the dental pulp (HP:0006479)1.48685616
119Ulnar bowing (HP:0003031)1.48359558
120Limited hip movement (HP:0008800)1.48097268
121Ventricular tachycardia (HP:0004756)1.48005597
122Fragile skin (HP:0001030)1.47613628
123Broad phalanges of the hand (HP:0009768)1.47588215
124Hepatoblastoma (HP:0002884)1.46307695
125Asymmetry of the thorax (HP:0001555)1.45893841
126Skin pits (HP:0100276)1.45888100
127Cubitus valgus (HP:0002967)1.45584811
128Difficulty climbing stairs (HP:0003551)1.45373673
129Sudden death (HP:0001699)1.45328008
130Aplasia involving bones of the extremities (HP:0009825)1.45326633
131Aplasia involving bones of the upper limbs (HP:0009823)1.45326633
132Aplasia of the phalanges of the hand (HP:0009802)1.45326633
133Papillary thyroid carcinoma (HP:0002895)1.44765972
134Popliteal pterygium (HP:0009756)1.44463691
135Absent eyebrow (HP:0002223)1.44191096
136Natal tooth (HP:0000695)1.44189551
137Ependymoma (HP:0002888)1.44021706
138Broad finger (HP:0001500)1.43778929
139Microglossia (HP:0000171)1.42198577
140Anal stenosis (HP:0002025)1.41457324
141Laryngomalacia (HP:0001601)1.41020134
142Dysmetric saccades (HP:0000641)1.40653302
143Partial duplication of thumb phalanx (HP:0009944)1.39833753
144Midface retrusion (HP:0011800)1.37893383
145Abnormality of the antihelix (HP:0009738)1.37388158
146Overriding aorta (HP:0002623)1.37326356
147Partial duplication of the phalanx of hand (HP:0009999)1.37252088
148Wide anterior fontanel (HP:0000260)1.37149390
149Bifid tongue (HP:0010297)1.35438978
150Deep philtrum (HP:0002002)1.35065149
151Cardiovascular calcification (HP:0011915)1.34997419
152Tracheal stenosis (HP:0002777)1.34882930
153Alacrima (HP:0000522)1.34209838
154Short nail (HP:0001799)1.33808411
155Aplasia/Hypoplasia of the sternum (HP:0006714)1.33304121

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.04077101
2TIE13.19688480
3CDK122.87346762
4PDGFRA2.40919128
5EPHA22.37609912
6RIPK12.34160762
7TRIB32.03818449
8CAMK1D2.01160252
9MST1R2.00281274
10CAMK1G2.00173755
11EPHB21.99797493
12TGFBR21.93328469
13TNIK1.89728285
14MET1.89466371
15PRKD31.86445669
16FER1.82259733
17DMPK1.80164136
18PTK61.80131899
19PKN21.77640151
20TTN1.75632201
21TSSK61.75203722
22DDR21.69687624
23ICK1.66616374
24KDR1.65469691
25FGFR21.63940081
26CASK1.56759211
27SIK11.56076570
28PTK21.54661578
29AKT31.50261874
30MAP3K91.50043480
31LATS21.49463124
32FRK1.40642798
33MYLK1.34883267
34PAK41.34759747
35MTOR1.33154447
36STK31.32805068
37MAP3K21.31772436
38MKNK21.26472400
39PBK1.22976944
40BRSK21.19991980
41PDGFRB1.18577847
42TYRO31.17828354
43PAK21.17523695
44PAK31.17047519
45FGFR11.15558882
46LMTK21.14442465
47BMX1.11340056
48BRD41.10985628
49INSRR1.07549669
50MST41.06584115
51TAF11.05650721
52WNK41.02837406
53WNK10.99437310
54CDK60.94868857
55PTK2B0.93541743
56STK390.91404560
57STK240.91162438
58TGFBR10.90521436
59PLK30.90280488
60STK38L0.89664482
61NUAK10.87708397
62RET0.86903975
63KSR20.82956226
64NTRK10.80508004
65EPHB10.78259354
66SCYL20.77624150
67MKNK10.76718040
68MAP3K120.76555314
69PDK20.75720221
70CDC42BPA0.75395047
71SGK20.74494299
72PLK20.74158231
73ROCK10.73562253
74PNCK0.73361944
75PRKD10.72460010
76WEE10.72239326
77BCR0.70060921
78BMPR1B0.69565644
79TRPM70.69446516
80ERBB20.68761424
81EEF2K0.66221140
82EIF2AK30.65262571
83STK380.65035358
84PAK60.62854930
85PIK3CA0.61620984
86NEK90.60998919
87ALK0.60975555
88GSK3A0.60452131
89EIF2AK10.60316574
90PLK40.60283879
91LRRK20.57096246
92NEK10.56297778
93MARK10.55778526
94MAP2K10.55722714
95NTRK30.55360968
96CSNK1A1L0.55276222
97SGK4940.54774591
98SGK2230.54774591
99ERBB30.52463031
100FGFR30.52110965
101NLK0.51340018
102SGK30.50266524
103PRKAA20.50198381
104MAP3K100.48650419
105CDC70.48615835
106MAP3K70.48040684
107STK100.47454429
108EPHA40.47044898
109PRKCH0.46088463
110CDK90.45849924
111TRIM280.45030600
112CSNK1D0.44713051
113PRKAA10.44245906
114BRSK10.41401027
115RPS6KB20.41101132
116CAMK2D0.41044327
117ERBB40.40604961
118PDK30.40021458
119PDK40.40021458
120INSR0.39970771
121CSNK1E0.39593120
122PLK10.39303867
123CAMK2B0.39262967
124AKT20.38907843
125MAP2K20.38228914
126ROCK20.37943404
127DYRK1B0.37824947
128KSR10.37781390
129SRC0.37320353
130* PRKCE0.37175829
131CDK80.37037393
132MAPKAPK50.36965057
133MAP3K40.36607005
134MAPK150.36316723
135TTK0.36043487
136NEK60.35982071
137ATM0.35772747
138CHEK10.35374093
139EGFR0.35064300
140MELK0.34027297
141YES10.33894190
142PRKD20.33833891
143AURKB0.33791325
144MAPK100.32836651
145MAP3K30.32457581

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.94321766
2ECM-receptor interaction_Homo sapiens_hsa045122.59762073
3* Adherens junction_Homo sapiens_hsa045202.53327063
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.16120744
5Focal adhesion_Homo sapiens_hsa045102.15098109
6Hippo signaling pathway_Homo sapiens_hsa043902.02533942
7* Tight junction_Homo sapiens_hsa045301.86210515
8Dilated cardiomyopathy_Homo sapiens_hsa054141.80539523
9Dorso-ventral axis formation_Homo sapiens_hsa043201.79277959
10Basal cell carcinoma_Homo sapiens_hsa052171.73193657
11Proteoglycans in cancer_Homo sapiens_hsa052051.71973197
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.64553405
13Vitamin B6 metabolism_Homo sapiens_hsa007501.62249499
14Small cell lung cancer_Homo sapiens_hsa052221.59451837
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46073355
16Hedgehog signaling pathway_Homo sapiens_hsa043401.46010581
17TGF-beta signaling pathway_Homo sapiens_hsa043501.44668106
18Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.39813518
19Protein digestion and absorption_Homo sapiens_hsa049741.39108411
20Lysine degradation_Homo sapiens_hsa003101.38810664
21Renal cell carcinoma_Homo sapiens_hsa052111.32127388
22Amoebiasis_Homo sapiens_hsa051461.29582050
23Axon guidance_Homo sapiens_hsa043601.29142448
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26765644
25MicroRNAs in cancer_Homo sapiens_hsa052061.24981879
26Thyroid hormone signaling pathway_Homo sapiens_hsa049191.20798307
27Rap1 signaling pathway_Homo sapiens_hsa040151.20122416
28Bladder cancer_Homo sapiens_hsa052191.16458778
29Wnt signaling pathway_Homo sapiens_hsa043101.15674432
30mTOR signaling pathway_Homo sapiens_hsa041501.15200101
31Bile secretion_Homo sapiens_hsa049761.15097117
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13615350
33Endometrial cancer_Homo sapiens_hsa052131.13158859
34Melanogenesis_Homo sapiens_hsa049161.09340394
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06938317
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06849556
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.05570448
38Estrogen signaling pathway_Homo sapiens_hsa049151.04437301
39Fatty acid biosynthesis_Homo sapiens_hsa000611.03069363
40Notch signaling pathway_Homo sapiens_hsa043301.02878215
41Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02873672
42Histidine metabolism_Homo sapiens_hsa003401.01356782
43Prostate cancer_Homo sapiens_hsa052151.01317223
44Glioma_Homo sapiens_hsa052140.98991169
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98681751
46Pathways in cancer_Homo sapiens_hsa052000.98423764
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97838929
48PI3K-Akt signaling pathway_Homo sapiens_hsa041510.96803168
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96650379
50Insulin resistance_Homo sapiens_hsa049310.96366476
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.94024100
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92465998
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92130026
54Type II diabetes mellitus_Homo sapiens_hsa049300.92081829
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91880235
56Propanoate metabolism_Homo sapiens_hsa006400.91098658
57Arginine and proline metabolism_Homo sapiens_hsa003300.89952851
58Cell cycle_Homo sapiens_hsa041100.89786417
59Chronic myeloid leukemia_Homo sapiens_hsa052200.88985729
60Oocyte meiosis_Homo sapiens_hsa041140.87850803
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86007814
62Pyruvate metabolism_Homo sapiens_hsa006200.85564615
63AMPK signaling pathway_Homo sapiens_hsa041520.85117549
64Insulin secretion_Homo sapiens_hsa049110.83199677
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83011167
66Selenocompound metabolism_Homo sapiens_hsa004500.82941061
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81925822
68Melanoma_Homo sapiens_hsa052180.81625951
69Colorectal cancer_Homo sapiens_hsa052100.81121498
70Mineral absorption_Homo sapiens_hsa049780.80979516
71Thyroid cancer_Homo sapiens_hsa052160.79578570
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79502557
73Renin secretion_Homo sapiens_hsa049240.79086720
74Glucagon signaling pathway_Homo sapiens_hsa049220.79080944
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.77373465
76Thyroid hormone synthesis_Homo sapiens_hsa049180.74095584
77Ovarian steroidogenesis_Homo sapiens_hsa049130.74037936
78cAMP signaling pathway_Homo sapiens_hsa040240.73915625
79beta-Alanine metabolism_Homo sapiens_hsa004100.73904779
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.73570887
81Pancreatic cancer_Homo sapiens_hsa052120.73374950
82Gastric acid secretion_Homo sapiens_hsa049710.72532006
83* Gap junction_Homo sapiens_hsa045400.72252000
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.71089896
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69837603
86Steroid biosynthesis_Homo sapiens_hsa001000.69822377
87Arginine biosynthesis_Homo sapiens_hsa002200.69594097
88ErbB signaling pathway_Homo sapiens_hsa040120.68464880
89Ras signaling pathway_Homo sapiens_hsa040140.65205747
90Oxytocin signaling pathway_Homo sapiens_hsa049210.65172341
91mRNA surveillance pathway_Homo sapiens_hsa030150.64547258
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64316884
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64227939
94Insulin signaling pathway_Homo sapiens_hsa049100.64164378
95VEGF signaling pathway_Homo sapiens_hsa043700.63842411
96Non-homologous end-joining_Homo sapiens_hsa034500.63151235
97HIF-1 signaling pathway_Homo sapiens_hsa040660.62674346
98Salivary secretion_Homo sapiens_hsa049700.62276591
99Glutamatergic synapse_Homo sapiens_hsa047240.62241629
100Fatty acid metabolism_Homo sapiens_hsa012120.62172596
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61908635
102GnRH signaling pathway_Homo sapiens_hsa049120.61420296
103Viral myocarditis_Homo sapiens_hsa054160.61396144
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.61015564
105Endocytosis_Homo sapiens_hsa041440.60457252
106FoxO signaling pathway_Homo sapiens_hsa040680.60176067
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59535475
108PPAR signaling pathway_Homo sapiens_hsa033200.58927569
109Platelet activation_Homo sapiens_hsa046110.57245837
110Pancreatic secretion_Homo sapiens_hsa049720.56851213
111Renin-angiotensin system_Homo sapiens_hsa046140.56668489
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56463703
113Choline metabolism in cancer_Homo sapiens_hsa052310.55225867
114Sphingolipid metabolism_Homo sapiens_hsa006000.54743932
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52834978
116RNA transport_Homo sapiens_hsa030130.52621277
117Circadian rhythm_Homo sapiens_hsa047100.52477562
118Inositol phosphate metabolism_Homo sapiens_hsa005620.52278169
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51826048
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51646433
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51079046
122Dopaminergic synapse_Homo sapiens_hsa047280.50713474
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.50534922
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50153347
125Amphetamine addiction_Homo sapiens_hsa050310.49812667
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49431588
127Circadian entrainment_Homo sapiens_hsa047130.49246231
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48169377
129Long-term potentiation_Homo sapiens_hsa047200.47788837

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