TJP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)6.01511412
2regulation of posttranscriptional gene silencing (GO:0060147)6.01511412
3regulation of gene silencing by miRNA (GO:0060964)6.01511412
4establishment of apical/basal cell polarity (GO:0035089)4.63285098
5axon ensheathment in central nervous system (GO:0032291)4.56843990
6central nervous system myelination (GO:0022010)4.56843990
7hemidesmosome assembly (GO:0031581)4.51408472
8regulation of hippo signaling (GO:0035330)4.47253691
9intestinal epithelial cell development (GO:0060576)4.36460480
10polarized epithelial cell differentiation (GO:0030859)4.26357861
11low-density lipoprotein particle clearance (GO:0034383)4.10376160
12regulation of cholesterol homeostasis (GO:2000188)4.09152688
13anterior/posterior axis specification, embryo (GO:0008595)3.95306544
14paraxial mesoderm development (GO:0048339)3.93481174
15desmosome organization (GO:0002934)3.90752312
16negative regulation of fibrinolysis (GO:0051918)3.75104503
17trophectodermal cell differentiation (GO:0001829)3.74576454
18regulation of apoptotic cell clearance (GO:2000425)3.74070962
19positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.73555369
20bundle of His cell to Purkinje myocyte communication (GO:0086069)3.72394289
21interferon-gamma secretion (GO:0072643)3.60855285
22establishment or maintenance of monopolar cell polarity (GO:0061339)3.59981655
23establishment of monopolar cell polarity (GO:0061162)3.59981655
24regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.57319903
25tight junction assembly (GO:0070830)3.54390578
26very-low-density lipoprotein particle assembly (GO:0034379)3.53912586
27cytoskeletal anchoring at plasma membrane (GO:0007016)3.53557798
28positive regulation of SMAD protein import into nucleus (GO:0060391)3.53117012
29virion attachment to host cell (GO:0019062)3.49459414
30adhesion of symbiont to host cell (GO:0044650)3.49459414
31plasma lipoprotein particle assembly (GO:0034377)3.47647512
32protein-lipid complex assembly (GO:0065005)3.46812086
33apical protein localization (GO:0045176)3.44365067
34nuclear pore organization (GO:0006999)3.41517470
35asymmetric protein localization (GO:0008105)3.35377062
36nuclear pore complex assembly (GO:0051292)3.33778613
37establishment or maintenance of bipolar cell polarity (GO:0061245)3.32283508
38establishment or maintenance of apical/basal cell polarity (GO:0035088)3.32283508
39epithelial cell-cell adhesion (GO:0090136)3.31043771
40dicarboxylic acid biosynthetic process (GO:0043650)3.28979401
41positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.28176020
42cell adhesion mediated by integrin (GO:0033627)3.27245974
43surfactant homeostasis (GO:0043129)3.25701236
44regulation of membrane protein ectodomain proteolysis (GO:0051043)3.25153829
45ensheathment of neurons (GO:0007272)3.21753327
46axon ensheathment (GO:0008366)3.21753327
47regulation of cardioblast differentiation (GO:0051890)3.20788252
48regulation of cholesterol esterification (GO:0010872)3.20498618
49regulation of water loss via skin (GO:0033561)3.17175399
50pinocytosis (GO:0006907)3.16743945
51protein carboxylation (GO:0018214)3.16603024
52peptidyl-glutamic acid carboxylation (GO:0017187)3.16603024
53renal filtration (GO:0097205)3.15681113
54regulation of early endosome to late endosome transport (GO:2000641)3.14700600
55apoptotic process involved in morphogenesis (GO:0060561)3.14051306
56regulation of SMAD protein import into nucleus (GO:0060390)3.11327656
57regulation of fibrinolysis (GO:0051917)3.11017131
58regulation of translational fidelity (GO:0006450)3.10975156
59heterochromatin organization (GO:0070828)3.10779463
60protein localization to endosome (GO:0036010)3.09443477
61myelin maintenance (GO:0043217)3.07628934
62myelination (GO:0042552)3.06144897
63pre-miRNA processing (GO:0031054)3.04874830
64fatty acid elongation (GO:0030497)3.04556556
65positive regulation of extracellular matrix organization (GO:1903055)3.03550054
66regulation of cholesterol biosynthetic process (GO:0045540)3.02869791
67determination of adult lifespan (GO:0008340)3.02329636
68plasma lipoprotein particle clearance (GO:0034381)3.02296319
69response to hepatocyte growth factor (GO:0035728)3.01125391
70cellular response to hepatocyte growth factor stimulus (GO:0035729)3.01125391
71cell fate commitment involved in formation of primary germ layer (GO:0060795)3.01025174
72regulation of protein activation cascade (GO:2000257)2.98937877
73regulation of complement activation (GO:0030449)2.97951973
74mesodermal cell differentiation (GO:0048333)2.96967793
75lung-associated mesenchyme development (GO:0060484)2.96022900
76notochord development (GO:0030903)2.95529299
77cell-cell junction assembly (GO:0007043)2.95296396
78negative regulation of cell fate commitment (GO:0010454)2.95129050
79Leydig cell differentiation (GO:0033327)2.94679767
80regulation of gene silencing (GO:0060968)2.93738436
81low-density lipoprotein particle remodeling (GO:0034374)2.93686307
82branching involved in mammary gland duct morphogenesis (GO:0060444)2.93404947
83multicellular organismal water homeostasis (GO:0050891)2.91123436
84ectoderm development (GO:0007398)2.89272759
85establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.89245828
86focal adhesion assembly (GO:0048041)2.88272699
87cell-substrate adherens junction assembly (GO:0007045)2.88272699
88Golgi transport vesicle coating (GO:0048200)2.88165798
89COPI coating of Golgi vesicle (GO:0048205)2.88165798
90fibrinolysis (GO:0042730)2.87737684
91skin morphogenesis (GO:0043589)2.87075945
92positive regulation of actin filament depolymerization (GO:0030836)2.86491188
93positive regulation of endothelial cell apoptotic process (GO:2000353)2.84993196
94branching involved in labyrinthine layer morphogenesis (GO:0060670)2.83211622
95positive regulation of pseudopodium assembly (GO:0031274)2.82754790
96positive regulation of Cdc42 GTPase activity (GO:0043089)2.82522215
97calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.82049502
98branching involved in salivary gland morphogenesis (GO:0060445)2.82048776
99regulation of extracellular matrix organization (GO:1903053)2.80070430
100positive regulation of steroid metabolic process (GO:0045940)2.79061558
101negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.78882649
102adhesion of symbiont to host (GO:0044406)2.78606282
103positive regulation of p38MAPK cascade (GO:1900745)2.76842028
104intestinal absorption (GO:0050892)2.76143924
105negative regulation of cell fate specification (GO:0009996)2.74538830
106establishment of epithelial cell polarity (GO:0090162)2.73572806
107DNA unwinding involved in DNA replication (GO:0006268)2.73187456
108labyrinthine layer development (GO:0060711)2.72793007
109phospholipid efflux (GO:0033700)2.68957722
110regulation of cholesterol storage (GO:0010885)2.67939494
111regulation of bile acid biosynthetic process (GO:0070857)2.67760904
112cholesterol efflux (GO:0033344)2.65027706
113apoptotic cell clearance (GO:0043277)2.62625886
114regulation of transforming growth factor beta1 production (GO:0032908)2.61859560
115activation of MAPKKK activity (GO:0000185)2.60656612
116DNA replication-dependent nucleosome organization (GO:0034723)2.60577868
117DNA replication-dependent nucleosome assembly (GO:0006335)2.60577868
118folic acid-containing compound biosynthetic process (GO:0009396)2.60355008
119lateral sprouting from an epithelium (GO:0060601)2.60254733
120intestinal cholesterol absorption (GO:0030299)2.58239631
121negative regulation of cholesterol transport (GO:0032375)2.57706766
122negative regulation of sterol transport (GO:0032372)2.57706766
123regulation of heterotypic cell-cell adhesion (GO:0034114)2.56480620
124positive regulation of catenin import into nucleus (GO:0035413)2.56120344
125cell volume homeostasis (GO:0006884)2.55663252
126alpha-linolenic acid metabolic process (GO:0036109)2.54915197
127transcytosis (GO:0045056)2.54768118
128protein-lipid complex subunit organization (GO:0071825)2.54572537
129negative regulation of hemostasis (GO:1900047)2.54368515
130negative regulation of blood coagulation (GO:0030195)2.54368515
131spindle assembly involved in mitosis (GO:0090307)2.54073956
132proline biosynthetic process (GO:0006561)2.53969151
133proline metabolic process (GO:0006560)2.53849263
134chemical homeostasis within a tissue (GO:0048875)2.53829434
135chaperone-mediated protein complex assembly (GO:0051131)2.53136043
136regulation of vitamin metabolic process (GO:0030656)2.53037496
137plasma lipoprotein particle remodeling (GO:0034369)2.52798359
138protein-lipid complex remodeling (GO:0034368)2.52798359
139macromolecular complex remodeling (GO:0034367)2.52798359
140cell-substrate junction assembly (GO:0007044)2.52692155
141basement membrane organization (GO:0071711)2.52618339
142regulation of sister chromatid cohesion (GO:0007063)2.51062773
143regulation of extracellular matrix disassembly (GO:0010715)2.50909478
144negative regulation of lipid transport (GO:0032369)2.50757414
145regulation of helicase activity (GO:0051095)2.50474127
146gap junction assembly (GO:0016264)2.50052774
147regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.50049706
148* hippo signaling (GO:0035329)2.49638242
149cellular protein complex localization (GO:0034629)2.49631559
150plasma lipoprotein particle organization (GO:0071827)2.49052786
151negative regulation of coagulation (GO:0050819)2.48708878
152triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.47555895
153regulation of histone H3-K9 methylation (GO:0051570)2.47333809
154chromatin assembly (GO:0031497)2.46730466
155establishment of skin barrier (GO:0061436)2.46594654
156positive regulation of steroid biosynthetic process (GO:0010893)2.46378750
157positive regulation of fatty acid biosynthetic process (GO:0045723)2.45175678
158regulation of podosome assembly (GO:0071801)2.43507029
159ethanol oxidation (GO:0006069)2.43336600
160regulation of cytokine secretion involved in immune response (GO:0002739)2.42787605
161retina vasculature morphogenesis in camera-type eye (GO:0061299)2.41535463
162lipoprotein metabolic process (GO:0042157)2.41504634
163epithelial cell differentiation involved in prostate gland development (GO:0060742)2.40874189
164regulation of cell fate commitment (GO:0010453)2.40205891
165keratinocyte differentiation (GO:0030216)2.39975627
166ear development (GO:0043583)2.39751445
167stress fiber assembly (GO:0043149)2.39745935
168epidermal cell differentiation (GO:0009913)2.39430861
169regulation of RNA export from nucleus (GO:0046831)2.38984953
170regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.38712475
171interleukin-6-mediated signaling pathway (GO:0070102)2.38693707
172positive regulation of blood coagulation (GO:0030194)2.38475407
173positive regulation of hemostasis (GO:1900048)2.38475407
174water homeostasis (GO:0030104)2.38301376
175cell junction maintenance (GO:0034331)2.37581610
176positive regulation of coagulation (GO:0050820)2.36759787
177glutamine family amino acid biosynthetic process (GO:0009084)2.36668310
178acute-phase response (GO:0006953)2.36316107
179adherens junction assembly (GO:0034333)2.35977997
180positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.35755933
181embryonic placenta development (GO:0001892)2.35713373
182glomerular filtration (GO:0003094)2.35426099
183embryonic process involved in female pregnancy (GO:0060136)2.35372909
184negative regulation of wound healing (GO:0061045)2.34050619
185ectodermal placode formation (GO:0060788)2.33757422
186cell junction assembly (GO:0034329)2.33324078

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.40488039
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.34125631
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.34125631
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.34125631
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.56700209
6E2F7_22180533_ChIP-Seq_HELA_Human3.46811545
7NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.45417978
8POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.20109947
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.00282390
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.92438153
11TCF3_18692474_ChIP-Seq_MEFs_Mouse2.87730933
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.83492688
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.70065113
14ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.51614102
15TCF3_18692474_ChIP-Seq_MESCs_Mouse2.50064480
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.45329081
17* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.31642127
18* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.25074349
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.23634541
20* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.22929080
21LXR_22158963_ChIP-Seq_LIVER_Mouse2.19229645
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.18725510
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.16430856
24SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.13661827
25HIF1A_21447827_ChIP-Seq_MCF-7_Human2.11753290
26* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.09551283
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.08724918
28ZNF263_19887448_ChIP-Seq_K562_Human2.08553870
29PPARA_22158963_ChIP-Seq_LIVER_Mouse2.07434122
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99558861
31AR_21909140_ChIP-Seq_LNCAP_Human1.96807858
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92686670
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.87824488
34* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.85516735
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.85291235
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.81755301
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.81300701
38NANOG_18692474_ChIP-Seq_MEFs_Mouse1.79718395
39* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.77612584
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.76009708
41* FOXA2_19822575_ChIP-Seq_HepG2_Human1.74562132
42SOX2_18555785_ChIP-Seq_MESCs_Mouse1.71370359
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.70507431
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.69361944
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.69220455
46* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.69185098
47* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.67251468
48* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66488580
49NANOG_18692474_ChIP-Seq_MESCs_Mouse1.65786317
50* FOXO3_23340844_ChIP-Seq_DLD1_Human1.65570094
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.63717804
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62689935
53SOX2_18692474_ChIP-Seq_MEFs_Mouse1.62358385
54* SOX2_20726797_ChIP-Seq_SW620_Human1.60884465
55TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.58005819
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57719823
57MYC_18555785_ChIP-Seq_MESCs_Mouse1.56345534
58* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.55252978
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51219839
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.49319206
61SOX2_18692474_ChIP-Seq_MESCs_Mouse1.49226014
62CLOCK_20551151_ChIP-Seq_293T_Human1.48922601
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48493547
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.46944575
65GATA6_25053715_ChIP-Seq_YYC3_Human1.46375094
66LXR_22292898_ChIP-Seq_THP-1_Human1.44221589
67* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.44188502
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43435545
69* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42251675
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.41975785
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41912888
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41542153
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40789667
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38356314
75* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.38106741
76RACK7_27058665_Chip-Seq_MCF-7_Human1.37060384
77ATF3_27146783_Chip-Seq_COLON_Human1.36774861
78KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36027018
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34539784
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.33891613
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33035515
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31560078
83* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.30989788
84OCT4_18692474_ChIP-Seq_MEFs_Mouse1.30065435
85NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29123776
86KDM2B_26808549_Chip-Seq_K562_Human1.28808545
87* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27565002
88* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27004166
89* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27004166
90* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.24077756
91SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23743706
92FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22645473
93POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.20538258
94PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17902414
95* TBX20_22080862_ChIP-Seq_HEART_Mouse1.17560083
96* TBX20_22328084_ChIP-Seq_HEART_Mouse1.17560083
97* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17147031
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16679780
99UBF1/2_26484160_Chip-Seq_HMECs_Human1.14370278
100TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13892161
101ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13749254
102ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12944336
103TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.12833542
104* GATA4_25053715_ChIP-Seq_YYC3_Human1.11504267
105TCF7_22412390_ChIP-Seq_EML_Mouse1.10194664
106MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09805578
107ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09626985
108* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09084894
109P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08708203
110RUNX1_27514584_Chip-Seq_MCF-7_Human1.08313706
111CDX2_20551321_ChIP-Seq_CACO-2_Human1.07283416
112KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06806915
113CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06025425
114NANOG_21062744_ChIP-ChIP_HESCs_Human1.05510746
115RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05278375
116CHD1_26751641_Chip-Seq_LNCaP_Human1.05225677
117* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04913410
118* GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.04277053
119* HNF4A_19822575_ChIP-Seq_HepG2_Human1.04244948
120EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03616489
121ERG_21242973_ChIP-ChIP_JURKAT_Human1.02070859
122RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02009285
123POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.01821614
124MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00212347
125NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99898999
126* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99888500
127MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99405717
128P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98942337
129* E2F4_17652178_ChIP-ChIP_JURKAT_Human0.97620601
130* KLF5_25053715_ChIP-Seq_YYC3_Human0.97338342
131STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97150616
132KAP1_27257070_Chip-Seq_ESCs_Mouse0.96411141
133CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95690594
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95346261
135KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94888546
136EP300_21415370_ChIP-Seq_HL-1_Mouse0.94307400
137GATA1_19941826_ChIP-Seq_K562_Human0.93794353
138HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93107302
139TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92599926
140PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91507475
141ELK3_25401928_ChIP-Seq_HUVEC_Human0.89559367
142TP53_22127205_ChIP-Seq_IMR90_Human0.88941391
143RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88510683
144FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87839800
145* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87758271
146* GATA3_24758297_ChIP-Seq_MCF-7_Human0.87585347

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.96017666
2MP0002139_abnormal_hepatobiliary_system3.52787069
3MP0002796_impaired_skin_barrier3.00708106
4MP0000537_abnormal_urethra_morphology2.96237378
5MP0010352_gastrointestinal_tract_polyps2.69554798
6MP0003941_abnormal_skin_development2.69399969
7MP0010678_abnormal_skin_adnexa2.62289818
8MP0005451_abnormal_body_composition2.48002198
9MP0003303_peritoneal_inflammation2.47846496
10MP0003705_abnormal_hypodermis_morpholog2.40618178
11MP0003191_abnormal_cellular_cholesterol2.28005218
12MP0004264_abnormal_extraembryonic_tissu2.26028246
13MP0004272_abnormal_basement_membrane2.20114043
14MP0009780_abnormal_chondrocyte_physiolo2.11734566
15MP0003300_gastrointestinal_ulcer2.11688868
16MP0005501_abnormal_skin_physiology2.08791172
17MP0003566_abnormal_cell_adhesion2.08604338
18MP0005360_urolithiasis2.04558393
19MP0000462_abnormal_digestive_system2.03308193
20MP0000383_abnormal_hair_follicle1.99108092
21MP0003453_abnormal_keratinocyte_physiol1.98897401
22MP0005058_abnormal_lysosome_morphology1.98256226
23MP0005365_abnormal_bile_salt1.98156903
24MP0000566_synostosis1.97925696
25MP0010030_abnormal_orbit_morphology1.95933024
26MP0001849_ear_inflammation1.93929668
27MP0003806_abnormal_nucleotide_metabolis1.93493127
28MP0005623_abnormal_meninges_morphology1.89052375
29MP0004957_abnormal_blastocyst_morpholog1.88554692
30MP0004185_abnormal_adipocyte_glucose1.80893007
31MP0003136_yellow_coat_color1.79567336
32MP0004133_heterotaxia1.78680826
33MP0002098_abnormal_vibrissa_morphology1.77657873
34MP0010368_abnormal_lymphatic_system1.77112725
35MP0005409_darkened_coat_color1.76003462
36MP0005666_abnormal_adipose_tissue1.72132959
37MP0000467_abnormal_esophagus_morphology1.69856087
38MP0000762_abnormal_tongue_morphology1.68641221
39* MP0001730_embryonic_growth_arrest1.67834611
40MP0003878_abnormal_ear_physiology1.67133483
41MP0005377_hearing/vestibular/ear_phenot1.67133483
42MP0001666_abnormal_nutrient_absorption1.63515867
43MP0003091_abnormal_cell_migration1.62153923
44MP0002653_abnormal_ependyma_morphology1.62116825
45MP0002254_reproductive_system_inflammat1.61680055
46MP0003283_abnormal_digestive_organ1.59824043
47MP0008004_abnormal_stomach_pH1.57223769
48MP0005076_abnormal_cell_differentiation1.54767483
49MP0003937_abnormal_limbs/digits/tail_de1.52456473
50* MP0002084_abnormal_developmental_patter1.52262349
51MP0003868_abnormal_feces_composition1.52204782
52MP0003119_abnormal_digestive_system1.51830105
53MP0003690_abnormal_glial_cell1.51506353
54MP0006054_spinal_hemorrhage1.47659675
55MP0004197_abnormal_fetal_growth/weight/1.47244905
56* MP0002085_abnormal_embryonic_tissue1.44926748
57MP0003890_abnormal_embryonic-extraembry1.43804229
58MP0004947_skin_inflammation1.41304980
59MP0001915_intracranial_hemorrhage1.38846471
60MP0000377_abnormal_hair_follicle1.36613469
61MP0002086_abnormal_extraembryonic_tissu1.36473070
62MP0004885_abnormal_endolymph1.36277884
63MP0005380_embryogenesis_phenotype1.35978617
64MP0001672_abnormal_embryogenesis/_devel1.35978617
65MP0003075_altered_response_to1.35907968
66MP0000647_abnormal_sebaceous_gland1.35262142
67MP0002089_abnormal_postnatal_growth/wei1.34526139
68* MP0003950_abnormal_plasma_membrane1.32315826
69MP0001216_abnormal_epidermal_layer1.32311655
70MP0005257_abnormal_intraocular_pressure1.32073553
71MP0001293_anophthalmia1.30080041
72MP0005375_adipose_tissue_phenotype1.29381627
73MP0004782_abnormal_surfactant_physiolog1.29036002
74MP0005275_abnormal_skin_tensile1.28072866
75MP0008057_abnormal_DNA_replication1.26674681
76MP0005023_abnormal_wound_healing1.26309976
77MP0005165_increased_susceptibility_to1.26006595
78MP0001485_abnormal_pinna_reflex1.24900887
79MP0003984_embryonic_growth_retardation1.21411209
80MP0000579_abnormal_nail_morphology1.19935364
81MP0002088_abnormal_embryonic_growth/wei1.19041278
82MP0002697_abnormal_eye_size1.18240074
83MP0001346_abnormal_lacrimal_gland1.18058125
84MP0000678_abnormal_parathyroid_gland1.16804477
85MP0000858_altered_metastatic_potential1.15625966
86* MP0001697_abnormal_embryo_size1.15255937
87* MP0000350_abnormal_cell_proliferation1.14573566
88MP0009053_abnormal_anal_canal1.14064960
89MP0008932_abnormal_embryonic_tissue1.11696105
90MP0002060_abnormal_skin_morphology1.11610738
91MP0000733_abnormal_muscle_development1.09992525
92MP0003111_abnormal_nucleus_morphology1.09746756
93MP0010329_abnormal_lipoprotein_level1.09352309
94MP0002111_abnormal_tail_morphology1.06786454
95MP0004510_myositis1.06578116
96MP0002092_abnormal_eye_morphology1.06497281
97MP0003011_delayed_dark_adaptation1.06492993
98MP0003329_amyloid_beta_deposits1.04384691
99MP0005248_abnormal_Harderian_gland1.03906848
100MP0000432_abnormal_head_morphology1.03074922
101MP0006072_abnormal_retinal_apoptosis1.01325753
102MP0005367_renal/urinary_system_phenotyp0.99988776
103MP0000516_abnormal_urinary_system0.99988776
104MP0004019_abnormal_vitamin_homeostasis0.99810923
105MP0005670_abnormal_white_adipose0.99079672
106MP0003195_calcinosis0.98967154
107MP0003077_abnormal_cell_cycle0.97265751
108MP0000534_abnormal_ureter_morphology0.96892863
109MP0000003_abnormal_adipose_tissue0.95416599
110MP0010771_integument_phenotype0.94573776
111MP0003755_abnormal_palate_morphology0.94198382
112MP0001286_abnormal_eye_development0.93464906
113MP0005167_abnormal_blood-brain_barrier0.93185511
114* MP0002080_prenatal_lethality0.92915894
115MP0000920_abnormal_myelination0.92582694
116MP0003693_abnormal_embryo_hatching0.90524798
117MP0002925_abnormal_cardiovascular_devel0.90349561
118MP0009840_abnormal_foam_cell0.90225211
119MP0003718_maternal_effect0.90207195
120MP0000428_abnormal_craniofacial_morphol0.89945327
121MP0003315_abnormal_perineum_morphology0.89113608
122MP0000609_abnormal_liver_physiology0.89007441
123MP0009672_abnormal_birth_weight0.87366631
124MP0003936_abnormal_reproductive_system0.86204094
125MP0002896_abnormal_bone_mineralization0.84326423
126MP0002877_abnormal_melanocyte_morpholog0.83777110
127MP0002118_abnormal_lipid_homeostasis0.83323471
128MP0010094_abnormal_chromosome_stability0.83264589
129MP0000604_amyloidosis0.83215331
130MP0008438_abnormal_cutaneous_collagen0.83207725
131MP0000627_abnormal_mammary_gland0.82779481
132MP0005391_vision/eye_phenotype0.82366401
133MP0000470_abnormal_stomach_morphology0.81122678
134MP0003935_abnormal_craniofacial_develop0.80417039
135MP0003115_abnormal_respiratory_system0.79951539
136MP0005166_decreased_susceptibility_to0.79816263
137MP0005408_hypopigmentation0.79729437
138MP0008875_abnormal_xenobiotic_pharmacok0.79292649
139MP0006138_congestive_heart_failure0.79136084
140MP0004858_abnormal_nervous_system0.78463653
141MP0005085_abnormal_gallbladder_physiolo0.78161520
142MP0002998_abnormal_bone_remodeling0.77803754
143MP0000477_abnormal_intestine_morphology0.76660812
144MP0003567_abnormal_fetal_cardiomyocyte0.76617150
145MP0002233_abnormal_nose_morphology0.75117038
146MP0005171_absent_coat_pigmentation0.74425074
147MP0010307_abnormal_tumor_latency0.74163247
148MP0010155_abnormal_intestine_physiology0.73198632
149MP0001661_extended_life_span0.71692076
150MP0003448_altered_tumor_morphology0.71476162
151MP0001853_heart_inflammation0.71296457
152MP0009643_abnormal_urine_homeostasis0.67585756
153MP0000767_abnormal_smooth_muscle0.67065038
154MP0005621_abnormal_cell_physiology0.66200376
155MP0003172_abnormal_lysosome_physiology0.64706305
156MP0003656_abnormal_erythrocyte_physiolo0.63967939
157MP0009931_abnormal_skin_appearance0.62899618
158MP0005464_abnormal_platelet_physiology0.62416929
159MP0010630_abnormal_cardiac_muscle0.62140884
160MP0008260_abnormal_autophagy0.61704149
161MP0009115_abnormal_fat_cell0.59382894
162MP0003123_paternal_imprinting0.58157878
163MP0002332_abnormal_exercise_endurance0.57859225
164MP0003183_abnormal_peptide_metabolism0.56851137

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.74218822
2Esophageal atresia (HP:0002032)4.26122560
3Complement deficiency (HP:0004431)3.72321200
4Abnormality of the salivary glands (HP:0010286)3.68328513
5Right ventricular cardiomyopathy (HP:0011663)3.59625205
6Ependymoma (HP:0002888)3.44709760
7Abnormality of complement system (HP:0005339)3.33598099
8Systemic lupus erythematosus (HP:0002725)3.29645752
9Glomerulonephritis (HP:0000099)3.21516364
10Milia (HP:0001056)3.06529822
11Myocardial infarction (HP:0001658)2.97206965
12Stenosis of the external auditory canal (HP:0000402)2.93341156
13Hemorrhage of the eye (HP:0011885)2.92559043
14Astrocytoma (HP:0009592)2.87876090
15Abnormality of the astrocytes (HP:0100707)2.87876090
16Short humerus (HP:0005792)2.85273861
17Pili torti (HP:0003777)2.80788399
18Xanthomatosis (HP:0000991)2.80183222
19Aplasia/hypoplasia of the humerus (HP:0006507)2.77464679
20Onycholysis (HP:0001806)2.72281071
21Vertebral clefting (HP:0008428)2.71306808
22Vascular calcification (HP:0004934)2.70613041
23Gastrointestinal atresia (HP:0002589)2.70135142
24Biliary tract neoplasm (HP:0100574)2.67098757
25Neoplasm of the oral cavity (HP:0100649)2.63786479
26Fused cervical vertebrae (HP:0002949)2.62952327
27Absent radius (HP:0003974)2.59733184
28Abnormality of the common coagulation pathway (HP:0010990)2.55592388
29Hypercholesterolemia (HP:0003124)2.55081503
30Fragile nails (HP:0001808)2.54196314
31Abnormality of nail color (HP:0100643)2.52952547
32Absent forearm bone (HP:0003953)2.50781454
33Aplasia involving forearm bones (HP:0009822)2.50781454
34Cardiovascular calcification (HP:0011915)2.49617473
35Hypobetalipoproteinemia (HP:0003563)2.47433249
36Ulnar bowing (HP:0003031)2.44570950
37Prolonged partial thromboplastin time (HP:0003645)2.43792105
38Selective tooth agenesis (HP:0001592)2.43646232
39Ankyloglossia (HP:0010296)2.43392926
40Advanced eruption of teeth (HP:0006288)2.43110108
41* Abnormality of monocarboxylic acid metabolism (HP:0010996)2.42464408
42Woolly hair (HP:0002224)2.41614429
43Congenital ichthyosiform erythroderma (HP:0007431)2.35985914
44Hypolipoproteinemia (HP:0010981)2.35073290
45Joint hemorrhage (HP:0005261)2.33800597
46Abnormality of the labia minora (HP:0012880)2.29101445
47Abnormality of carpal bone ossification (HP:0006257)2.27030842
48Hypoalphalipoproteinemia (HP:0003233)2.26386762
49Missing ribs (HP:0000921)2.25727801
50Hypoplastic labia majora (HP:0000059)2.24319842
51Nail dystrophy (HP:0008404)2.23964173
52Protrusio acetabuli (HP:0003179)2.21282970
53Abnormality of the Achilles tendon (HP:0005109)2.20612859
54Abnormality of aromatic amino acid family metabolism (HP:0004338)2.19519111
55Axonal loss (HP:0003447)2.18252541
56Menorrhagia (HP:0000132)2.18085559
57Cerebral hypomyelination (HP:0006808)2.17021176
58Rib fusion (HP:0000902)2.15291692
59Atrophic scars (HP:0001075)2.14996819
60Parakeratosis (HP:0001036)2.14585248
61Nephritis (HP:0000123)2.14400269
62Alacrima (HP:0000522)2.14178249
63Ileus (HP:0002595)2.13146978
64Hypotrichosis (HP:0001006)2.12874394
65Focal segmental glomerulosclerosis (HP:0000097)2.12735241
66Abnormal vertebral ossification (HP:0100569)2.12053237
67Neonatal death (HP:0003811)2.10844661
68Deviation of the thumb (HP:0009603)2.08641226
69Malnutrition (HP:0004395)2.08634390
70Shawl scrotum (HP:0000049)2.08131154
71Bronchomalacia (HP:0002780)2.07406626
72Pterygium (HP:0001059)2.06567195
73Breast hypoplasia (HP:0003187)2.06298942
74Glioma (HP:0009733)2.06059322
75Tetraparesis (HP:0002273)2.04583684
76Hyporeflexia of lower limbs (HP:0002600)2.03196841
77Vertebral hypoplasia (HP:0008417)2.02211042
78Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.02211042
79Abnormal ossification of hand bones (HP:0005921)2.01936021
80Nuclear cataract (HP:0100018)2.01148735
81Subcapsular cataract (HP:0000523)2.00869745
82Natal tooth (HP:0000695)2.00074888
83Hyperacusis (HP:0010780)1.99707831
84Proximal placement of thumb (HP:0009623)1.99329554
85Distal lower limb amyotrophy (HP:0008944)1.99241739
86Coronal craniosynostosis (HP:0004440)1.98062907
87Polygenic inheritance (HP:0010982)1.97004253
88Abnormality of the labia majora (HP:0012881)1.96896334
89Abnormality of the distal phalanx of the thumb (HP:0009617)1.95943890
90Hypopigmentation of the fundus (HP:0007894)1.95614612
91Pseudobulbar signs (HP:0002200)1.95398884
92Distal lower limb muscle weakness (HP:0009053)1.95356656
93Palmoplantar hyperkeratosis (HP:0000972)1.95338823
94Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.95284327
95Degeneration of the lateral corticospinal tracts (HP:0002314)1.95284327
96Plantar hyperkeratosis (HP:0007556)1.93931117
97Back pain (HP:0003418)1.93899420
98Gastrointestinal carcinoma (HP:0002672)1.93846686
99Malignant gastrointestinal tract tumors (HP:0006749)1.93846686
100Curly hair (HP:0002212)1.92968316
101Achilles tendon contracture (HP:0001771)1.92539813
102Tracheal stenosis (HP:0002777)1.90927645
103Glomerulosclerosis (HP:0000096)1.90708376
104Abnormal biliary tract morphology (HP:0012440)1.89275186
105Distal upper limb amyotrophy (HP:0007149)1.88966561
106Upper limb amyotrophy (HP:0009129)1.88966561
107Abnormality of the fetal cardiovascular system (HP:0010948)1.88590192
108Abnormal umbilical cord blood vessels (HP:0011403)1.88590192
109Single umbilical artery (HP:0001195)1.88590192
110Sensory axonal neuropathy (HP:0003390)1.88292811
111Rhabdomyosarcoma (HP:0002859)1.86943836
112Hydroxyprolinuria (HP:0003080)1.86751282
113Abnormality of proline metabolism (HP:0010907)1.86751282
114Esophageal varix (HP:0002040)1.86607173
115Osteolytic defects of the hand bones (HP:0009699)1.86224125
116Osteolytic defects of the phalanges of the hand (HP:0009771)1.86224125
117Short nail (HP:0001799)1.86123999
118Thick nail (HP:0001805)1.85361011
119Aplasia involving bones of the upper limbs (HP:0009823)1.84856275
120Aplasia of the phalanges of the hand (HP:0009802)1.84856275
121Aplasia involving bones of the extremities (HP:0009825)1.84856275
122Skin nodule (HP:0200036)1.84774681
123Shallow orbits (HP:0000586)1.84745557
124Abnormality of oral frenula (HP:0000190)1.84237508
125Aplasia/Hypoplasia of the spleen (HP:0010451)1.82520784
126Hyperparathyroidism (HP:0000843)1.82072365
127Amyloidosis (HP:0011034)1.81890515
128Partial duplication of thumb phalanx (HP:0009944)1.80588507
129Cerebral aneurysm (HP:0004944)1.80325710
130Large earlobe (HP:0009748)1.80276079
131Abnormal auditory evoked potentials (HP:0006958)1.79867720
132Vertebral fusion (HP:0002948)1.79096910
133Acanthosis nigricans (HP:0000956)1.78599407
134Turricephaly (HP:0000262)1.77625516
135Palmar hyperkeratosis (HP:0010765)1.77515098
136Neoplasm of striated muscle (HP:0009728)1.77155256
137Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.77005506
138Vertebral compression fractures (HP:0002953)1.76790292
139Asymmetry of the thorax (HP:0001555)1.76749671
140Supernumerary ribs (HP:0005815)1.76407191
141Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.76317790
142Abnormality of the gastric mucosa (HP:0004295)1.75822770
143Colon cancer (HP:0003003)1.75627166
144Asplenia (HP:0001746)1.74795243
145Relative macrocephaly (HP:0004482)1.73979688
146Cerebral inclusion bodies (HP:0100314)1.73720434
147Abnormality of cochlea (HP:0000375)1.72283962
148Abnormal hair laboratory examination (HP:0003328)1.71420599
149Arterial tortuosity (HP:0005116)1.70962465
150Increased connective tissue (HP:0009025)1.70527224
151Abnormal sex determination (HP:0012244)1.70407831
152Sex reversal (HP:0012245)1.70407831
153Insidious onset (HP:0003587)1.70236469
154Termporal pattern (HP:0011008)1.70236469
155Mitral stenosis (HP:0001718)1.70181666
156Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.70046089
157Abnormal hand bone ossification (HP:0010660)1.69877418
158Trismus (HP:0000211)1.69573104
159Thin bony cortex (HP:0002753)1.68993970
160Septo-optic dysplasia (HP:0100842)1.68877559
161Cervical subluxation (HP:0003308)1.68487065
162Lip pit (HP:0100267)1.68330173
163Progressive sensorineural hearing impairment (HP:0000408)1.66975920
164Hypoplasia of dental enamel (HP:0006297)1.66181531
165Morphological abnormality of the inner ear (HP:0011390)1.66054181
166Abnormal blistering of the skin (HP:0008066)1.65322445
167Abnormality of abdominal situs (HP:0011620)1.65166589
168Abdominal situs inversus (HP:0003363)1.65166589
169Epidermoid cyst (HP:0200040)1.65022728
170Abnormal hemoglobin (HP:0011902)1.64907364
171Alopecia of scalp (HP:0002293)1.64429050
172Abnormality of glutamine family amino acid metabolism (HP:0010902)1.64143012
173Premature rupture of membranes (HP:0001788)1.63627019
174Flat acetabular roof (HP:0003180)1.63578612
175Short hallux (HP:0010109)1.63474021
176Conjugated hyperbilirubinemia (HP:0002908)1.62682116
177Peripheral hypomyelination (HP:0007182)1.62477693
178Absent toe (HP:0010760)1.61853811
179Neurofibrillary tangles (HP:0002185)1.61398313
180Polar cataract (HP:0010696)1.61241633
181Uterine neoplasm (HP:0010784)1.60390230
182Interstitial pulmonary disease (HP:0006530)1.60385752
183Purpura (HP:0000979)1.60032547
184Broad face (HP:0000283)1.59909311
185Hyperactive renin-angiotensin system (HP:0000841)1.59442690

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.10763579
2IRAK33.70521584
3MET3.42586158
4FGFR43.06966586
5CDK123.01060336
6MST42.63742648
7STK392.59625488
8MAP3K92.56525973
9LATS12.55342066
10SMG12.49663514
11RPS6KB22.43404696
12TRIB32.42513971
13EPHB12.07966582
14ICK1.99831890
15MST1R1.92510131
16PBK1.80225258
17TTK1.75757966
18BCR1.66149748
19FGFR31.64464827
20STK101.60696383
21MAP2K21.53007431
22PNCK1.51050262
23SIK11.49183213
24ERN11.48562550
25FER1.47830369
26BMX1.43110777
27PAK41.40126511
28DDR21.39258390
29WEE11.38900607
30PRPF4B1.36286222
31TYRO31.34878109
32STK241.33665826
33OXSR11.32762573
34CDC42BPA1.31470341
35PTK61.29297114
36PTK21.26403608
37RIPK11.25546735
38FGFR21.24022289
39MAP3K81.21452308
40NME21.18462660
41CDC71.18283485
42EPHB21.14428981
43ERBB41.07089597
44MAP3K131.06556721
45BUB11.05597704
46MAP3K21.04941274
47TIE11.04565685
48LIMK11.03834265
49AKT31.02036045
50CDK71.01970114
51TESK21.01444970
52MTOR0.99698041
53TGFBR20.97965154
54STK30.95044245
55MAP3K140.91725713
56ARAF0.91674932
57LRRK20.89755486
58MELK0.89416061
59TAOK20.88505370
60ALK0.87573417
61PAK20.86471434
62PRKCI0.86431012
63MAP3K30.86346969
64STK38L0.85857618
65MAP3K10.83336257
66TTN0.83028905
67BRD40.82703991
68FGR0.82145614
69PDGFRA0.81687984
70FGFR10.81381408
71MAP3K100.81211445
72NTRK10.79775824
73ROCK20.79341528
74WNK10.79155210
75LATS20.78830009
76SGK30.78138283
77EEF2K0.77600355
78TESK10.75956571
79CDK60.75884441
80GSK3A0.75520713
81NEK10.74832052
82PDPK10.74036646
83TSSK60.73130188
84NEK20.71674054
85WNK40.70019514
86PKN20.68928635
87AURKB0.66940034
88CHEK10.66835140
89LMTK20.66312655
90MOS0.65974637
91TRPM70.65841076
92TBK10.65236144
93PAK30.65041701
94PRKAA20.64603458
95MATK0.64579393
96PDGFRB0.62194201
97GRK10.60680299
98MAPK150.60162389
99SCYL20.59196515
100CSNK1A1L0.59129477
101ERBB20.58979582
102MYLK0.58732682
103EIF2AK10.58490276
104PRKG20.57678900
105DMPK0.57263500
106TAOK10.56995551
107PLK10.56814019
108* CSNK1D0.56606492
109PAK10.56326967
110KSR20.55986971
111* CSNK1E0.54569290
112PASK0.53802646
113AURKA0.53516976
114RET0.49899193
115MAPK110.49577109
116CHEK20.49403018
117MAPKAPK30.49217724
118DYRK1B0.47811171
119STK40.47712338
120CSNK1G10.42909955
121CDK40.42010933
122NEK90.41998994
123AKT20.41694712
124PRKD10.41686834
125CSNK1G30.41001323
126PKN10.40652083
127CDK190.40542344
128* CDK20.40182037
129PDK20.39615381
130KDR0.39364650
131TLK10.39353998
132CAMK2D0.39242415
133CAMK1D0.38605997
134STK380.37692815
135BRAF0.35833731
136MAP3K120.34129800
137ABL20.34084248
138SGK4940.30613076
139SGK2230.30613076
140IRAK20.30425328
141CSK0.29165124
142CHUK0.28422875
143CAMK2G0.27476153
144MAPK100.26519211
145PDK10.26380959
146CDK90.26166215
147SRC0.25712230

Predicted pathways (KEGG)

RankGene SetZ-score
1* Tight junction_Homo sapiens_hsa045302.93268983
2Complement and coagulation cascades_Homo sapiens_hsa046102.81055621
3Hippo signaling pathway_Homo sapiens_hsa043902.62943220
4Nitrogen metabolism_Homo sapiens_hsa009102.40596954
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.40253756
6Adherens junction_Homo sapiens_hsa045202.32441907
7Steroid biosynthesis_Homo sapiens_hsa001002.23752745
8Basal cell carcinoma_Homo sapiens_hsa052172.18645767
9ECM-receptor interaction_Homo sapiens_hsa045122.14342989
10Phenylalanine metabolism_Homo sapiens_hsa003602.02710735
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.01886671
12Arginine biosynthesis_Homo sapiens_hsa002202.01004661
13Other glycan degradation_Homo sapiens_hsa005111.99235488
14PPAR signaling pathway_Homo sapiens_hsa033201.98354393
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.96715373
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.95645583
17Mineral absorption_Homo sapiens_hsa049781.89217150
18Mismatch repair_Homo sapiens_hsa034301.78285940
19Hedgehog signaling pathway_Homo sapiens_hsa043401.76210442
20Prion diseases_Homo sapiens_hsa050201.75877419
21One carbon pool by folate_Homo sapiens_hsa006701.75089586
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70370715
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66890535
24RNA transport_Homo sapiens_hsa030131.61694261
25TGF-beta signaling pathway_Homo sapiens_hsa043501.57880832
26Ether lipid metabolism_Homo sapiens_hsa005651.56705302
27Small cell lung cancer_Homo sapiens_hsa052221.53674672
28Bladder cancer_Homo sapiens_hsa052191.53047881
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.51474590
30MicroRNAs in cancer_Homo sapiens_hsa052061.49749766
31Linoleic acid metabolism_Homo sapiens_hsa005911.49426803
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49097270
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48622530
34Fatty acid elongation_Homo sapiens_hsa000621.47412758
35Fat digestion and absorption_Homo sapiens_hsa049751.45454558
36Fatty acid degradation_Homo sapiens_hsa000711.44394404
37Proteoglycans in cancer_Homo sapiens_hsa052051.41657366
38Glutathione metabolism_Homo sapiens_hsa004801.40739691
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.36379358
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34310153
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.34099649
42Focal adhesion_Homo sapiens_hsa045101.33021670
43Notch signaling pathway_Homo sapiens_hsa043301.30724102
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.30701714
45Arginine and proline metabolism_Homo sapiens_hsa003301.27999523
46Renal cell carcinoma_Homo sapiens_hsa052111.27775459
47Fatty acid biosynthesis_Homo sapiens_hsa000611.24518658
48Spliceosome_Homo sapiens_hsa030401.22343086
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22193231
50Galactose metabolism_Homo sapiens_hsa000521.15636131
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13825356
52Histidine metabolism_Homo sapiens_hsa003401.13563495
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13546182
54Sphingolipid metabolism_Homo sapiens_hsa006001.13492335
55Pentose and glucuronate interconversions_Homo sapiens_hsa000401.11138146
56Fatty acid metabolism_Homo sapiens_hsa012121.10284748
57Tyrosine metabolism_Homo sapiens_hsa003501.09478776
58Glycosaminoglycan degradation_Homo sapiens_hsa005311.09251212
59Cell cycle_Homo sapiens_hsa041101.08569276
60Sulfur metabolism_Homo sapiens_hsa009201.07547342
61Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05666218
62Starch and sucrose metabolism_Homo sapiens_hsa005001.02558244
63Selenocompound metabolism_Homo sapiens_hsa004501.01954624
64Biosynthesis of amino acids_Homo sapiens_hsa012301.01951502
65Dorso-ventral axis formation_Homo sapiens_hsa043201.01908268
66Vitamin digestion and absorption_Homo sapiens_hsa049771.01629552
67mRNA surveillance pathway_Homo sapiens_hsa030151.01569484
68Protein digestion and absorption_Homo sapiens_hsa049741.00307366
69Adipocytokine signaling pathway_Homo sapiens_hsa049201.00004401
70Pertussis_Homo sapiens_hsa051330.99996985
71DNA replication_Homo sapiens_hsa030300.98883875
72Thyroid cancer_Homo sapiens_hsa052160.97670623
73Pathways in cancer_Homo sapiens_hsa052000.97002792
74p53 signaling pathway_Homo sapiens_hsa041150.96849498
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95714720
76Viral carcinogenesis_Homo sapiens_hsa052030.93230645
77Hepatitis C_Homo sapiens_hsa051600.92306924
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91050385
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89956732
80Axon guidance_Homo sapiens_hsa043600.88876068
81Nucleotide excision repair_Homo sapiens_hsa034200.87970079
82Wnt signaling pathway_Homo sapiens_hsa043100.85642958
83Folate biosynthesis_Homo sapiens_hsa007900.84850470
84Chronic myeloid leukemia_Homo sapiens_hsa052200.84385661
85Prostate cancer_Homo sapiens_hsa052150.84041903
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.83834021
87beta-Alanine metabolism_Homo sapiens_hsa004100.81799192
88TNF signaling pathway_Homo sapiens_hsa046680.80522367
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79690171
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79359359
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78390732
92Insulin resistance_Homo sapiens_hsa049310.78294139
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77572154
94Lysosome_Homo sapiens_hsa041420.77165985
95Systemic lupus erythematosus_Homo sapiens_hsa053220.76380237
96Amoebiasis_Homo sapiens_hsa051460.76359259
97Renin-angiotensin system_Homo sapiens_hsa046140.76259496
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.76252285
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72582902
100Arachidonic acid metabolism_Homo sapiens_hsa005900.72149486
101African trypanosomiasis_Homo sapiens_hsa051430.69784161
102Insulin signaling pathway_Homo sapiens_hsa049100.69282942
103Thyroid hormone synthesis_Homo sapiens_hsa049180.69203316
104Salmonella infection_Homo sapiens_hsa051320.69048811
105Fructose and mannose metabolism_Homo sapiens_hsa000510.68906070
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66259951
107Pyruvate metabolism_Homo sapiens_hsa006200.66201807
108Staphylococcus aureus infection_Homo sapiens_hsa051500.65629215
109VEGF signaling pathway_Homo sapiens_hsa043700.63498180
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63418530
111Lysine degradation_Homo sapiens_hsa003100.61783771
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60308480
113Rap1 signaling pathway_Homo sapiens_hsa040150.60009240
114Pancreatic cancer_Homo sapiens_hsa052120.59146662
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58994716
116Endocytosis_Homo sapiens_hsa041440.56887623
117Bile secretion_Homo sapiens_hsa049760.56821073
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55649691
119Pentose phosphate pathway_Homo sapiens_hsa000300.54162523
120Retinol metabolism_Homo sapiens_hsa008300.53355897
121Melanoma_Homo sapiens_hsa052180.53134378
122Tryptophan metabolism_Homo sapiens_hsa003800.52056846
123AMPK signaling pathway_Homo sapiens_hsa041520.51749182
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.51450276
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50645685
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49334570
127Glycerolipid metabolism_Homo sapiens_hsa005610.49130010
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48848365
129Phototransduction_Homo sapiens_hsa047440.48469373
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46907993
131GnRH signaling pathway_Homo sapiens_hsa049120.46572861
132NF-kappa B signaling pathway_Homo sapiens_hsa040640.46467554
133Homologous recombination_Homo sapiens_hsa034400.45908484
134Endometrial cancer_Homo sapiens_hsa052130.45760949
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45109930
136Influenza A_Homo sapiens_hsa051640.44868582
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.44606633
138Chemical carcinogenesis_Homo sapiens_hsa052040.43578061
139Toxoplasmosis_Homo sapiens_hsa051450.43532395
140Basal transcription factors_Homo sapiens_hsa030220.43145669
141Shigellosis_Homo sapiens_hsa051310.42721962
142RNA polymerase_Homo sapiens_hsa030200.42700287
143Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41426006
144Melanogenesis_Homo sapiens_hsa049160.40574841
145Carbon metabolism_Homo sapiens_hsa012000.39763354
146Vitamin B6 metabolism_Homo sapiens_hsa007500.38942998
147Glycerophospholipid metabolism_Homo sapiens_hsa005640.38690811
148mTOR signaling pathway_Homo sapiens_hsa041500.35896701
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.35875258

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