TJP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.38870786
2cilium or flagellum-dependent cell motility (GO:0001539)7.18657467
3motile cilium assembly (GO:0044458)6.93596361
4cilium movement (GO:0003341)6.03794333
5vitamin transmembrane transport (GO:0035461)5.91580804
6intestinal absorption (GO:0050892)5.60627873
7intestinal cholesterol absorption (GO:0030299)5.51416035
8sulfur amino acid catabolic process (GO:0000098)5.45563034
9bundle of His cell to Purkinje myocyte communication (GO:0086069)5.16841411
10epithelial cilium movement (GO:0003351)4.80950564
11bile acid and bile salt transport (GO:0015721)4.77349147
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.72272638
13intestinal epithelial cell development (GO:0060576)4.53381270
14transcytosis (GO:0045056)4.37729685
15regulation of cholesterol homeostasis (GO:2000188)4.35107229
16multicellular organismal water homeostasis (GO:0050891)4.34086010
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.29397012
18homocysteine metabolic process (GO:0050667)4.25887001
19cysteine metabolic process (GO:0006534)4.16272597
20phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.13191010
21L-phenylalanine metabolic process (GO:0006558)4.12562362
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.12562362
23epoxygenase P450 pathway (GO:0019373)4.12435665
24oligosaccharide biosynthetic process (GO:0009312)4.11198631
25positive regulation of Cdc42 GTPase activity (GO:0043089)4.10039087
26sperm capacitation (GO:0048240)4.09760460
27UDP-N-acetylglucosamine metabolic process (GO:0006047)4.08784519
28urea cycle (GO:0000050)4.07381321
29urea metabolic process (GO:0019627)4.07381321
30negative regulation of cholesterol transport (GO:0032375)4.01610266
31negative regulation of sterol transport (GO:0032372)4.01610266
32interferon-gamma secretion (GO:0072643)4.00517642
33establishment of apical/basal cell polarity (GO:0035089)4.00394299
34regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.98147079
35regulation of triglyceride catabolic process (GO:0010896)3.96003335
36regulation of bile acid biosynthetic process (GO:0070857)3.94942304
37erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.89851295
38L-phenylalanine catabolic process (GO:0006559)3.89851295
39maintenance of gastrointestinal epithelium (GO:0030277)3.85736715
40drug catabolic process (GO:0042737)3.84849631
41NADH metabolic process (GO:0006734)3.84389274
42ethanol metabolic process (GO:0006067)3.84017228
43phospholipid efflux (GO:0033700)3.82437947
44lung epithelium development (GO:0060428)3.81476206
45flavonoid metabolic process (GO:0009812)3.78507087
46primary alcohol catabolic process (GO:0034310)3.74528582
47regulation of guanylate cyclase activity (GO:0031282)3.74166457
48aromatic amino acid family catabolic process (GO:0009074)3.71910572
49kynurenine metabolic process (GO:0070189)3.71554142
50nitrogen cycle metabolic process (GO:0071941)3.68229462
51complement activation, alternative pathway (GO:0006957)3.67959176
52diterpenoid biosynthetic process (GO:0016102)3.67622779
53glutathione biosynthetic process (GO:0006750)3.66774566
54GDP-mannose metabolic process (GO:0019673)3.66473972
55detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.65753843
56axoneme assembly (GO:0035082)3.64983493
57desmosome organization (GO:0002934)3.64509202
58indolalkylamine catabolic process (GO:0046218)3.63790731
59tryptophan catabolic process (GO:0006569)3.63790731
60indole-containing compound catabolic process (GO:0042436)3.63790731
61high-density lipoprotein particle remodeling (GO:0034375)3.55203136
62alpha-linolenic acid metabolic process (GO:0036109)3.49427584
63uronic acid metabolic process (GO:0006063)3.49299097
64glucuronate metabolic process (GO:0019585)3.49299097
65water homeostasis (GO:0030104)3.48436436
66ethanol oxidation (GO:0006069)3.47795317
67regulation of cholesterol esterification (GO:0010872)3.44277647
68bile acid metabolic process (GO:0008206)3.43028423
69renal system process involved in regulation of blood volume (GO:0001977)3.42634846
70cholesterol homeostasis (GO:0042632)3.39169620
71nonribosomal peptide biosynthetic process (GO:0019184)3.38176283
72positive regulation of lipoprotein lipase activity (GO:0051006)3.37099141
73positive regulation of triglyceride lipase activity (GO:0061365)3.37099141
74regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.36392528
75plasma lipoprotein particle assembly (GO:0034377)3.35761119
76sterol homeostasis (GO:0055092)3.34053062
77acylglycerol homeostasis (GO:0055090)3.33566350
78triglyceride homeostasis (GO:0070328)3.33566350
79tryptophan metabolic process (GO:0006568)3.32074259
80COPI coating of Golgi vesicle (GO:0048205)3.29579784
81Golgi transport vesicle coating (GO:0048200)3.29579784
82drug transmembrane transport (GO:0006855)3.28961335
83excretion (GO:0007588)3.28077704
84amino-acid betaine metabolic process (GO:0006577)3.27818929
85sphingomyelin metabolic process (GO:0006684)3.27035461
86proline biosynthetic process (GO:0006561)3.26289415
87regulation of protein activation cascade (GO:2000257)3.23847513
88phospholipid homeostasis (GO:0055091)3.22821139
89plasma lipoprotein particle remodeling (GO:0034369)3.21487108
90protein-lipid complex remodeling (GO:0034368)3.21487108
91macromolecular complex remodeling (GO:0034367)3.21487108
92establishment or maintenance of monopolar cell polarity (GO:0061339)3.21368131
93establishment of monopolar cell polarity (GO:0061162)3.21368131
94cellular glucuronidation (GO:0052695)3.20522300
95left/right pattern formation (GO:0060972)3.20473784
96purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.20310704
973-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.20310704
98lipoprotein metabolic process (GO:0042157)3.19753174
99reverse cholesterol transport (GO:0043691)3.18816677
100ear development (GO:0043583)3.18147240
101serine family amino acid catabolic process (GO:0009071)3.17536073
102fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.17253978
103glyoxylate metabolic process (GO:0046487)3.16834978
104bile acid biosynthetic process (GO:0006699)3.15978168
105hepatocyte apoptotic process (GO:0097284)3.15338954
106drug transport (GO:0015893)3.13662301
107regulation of complement activation (GO:0030449)3.11323168
108digestive system process (GO:0022600)3.09293682
109very-low-density lipoprotein particle assembly (GO:0034379)3.09158959
110primary alcohol metabolic process (GO:0034308)3.09080458
111regulation of interleukin-13 production (GO:0032656)3.08860995
112epithelial structure maintenance (GO:0010669)3.07702670
113sulfate transmembrane transport (GO:1902358)3.06898304
114positive regulation of triglyceride metabolic process (GO:0090208)3.06763862
115hemidesmosome assembly (GO:0031581)3.05400206
116angiotensin maturation (GO:0002003)3.04435249
117cellular ketone body metabolic process (GO:0046950)3.04037082
118calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.03037173
119tight junction assembly (GO:0070830)3.02214281
120exogenous drug catabolic process (GO:0042738)3.01790339
121protein-lipid complex assembly (GO:0065005)3.01505985
122gap junction assembly (GO:0016264)3.00996200
123negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.00535473
124cholesterol efflux (GO:0033344)2.98460355
125establishment or maintenance of apical/basal cell polarity (GO:0035088)2.97724414
126establishment or maintenance of bipolar cell polarity (GO:0061245)2.97724414
127regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.96909909
128endocrine process (GO:0050886)2.96909909
129regulation of systemic arterial blood pressure by hormone (GO:0001990)2.96909909
130regulation of water loss via skin (GO:0033561)2.96714822
131regulation of interleukin-5 production (GO:0032674)2.96237118
132positive regulation of respiratory burst (GO:0060267)2.95567968
133striated muscle atrophy (GO:0014891)2.95475913
134renal absorption (GO:0070293)2.94348738
135pyrimidine-containing compound transmembrane transport (GO:0072531)2.93977076
136cellular modified amino acid catabolic process (GO:0042219)2.93390597
137proline metabolic process (GO:0006560)2.92042713
138glutamine family amino acid biosynthetic process (GO:0009084)2.91390796
139sodium ion homeostasis (GO:0055078)2.91304543
140epithelial cell-cell adhesion (GO:0090136)2.90771154
141positive regulation of pseudopodium assembly (GO:0031274)2.90734879
142response to nitrosative stress (GO:0051409)2.90438422
143amyloid precursor protein catabolic process (GO:0042987)2.90393151
144peptidyl-tyrosine autophosphorylation (GO:0038083)2.90385580
145vitamin transport (GO:0051180)2.90195222
146glutathione derivative metabolic process (GO:1901685)2.87785715
147glutathione derivative biosynthetic process (GO:1901687)2.87785715
148negative regulation of T cell differentiation in thymus (GO:0033085)2.86242729
149short-chain fatty acid metabolic process (GO:0046459)2.85605825
150aromatic amino acid family metabolic process (GO:0009072)2.81323249
151fat-soluble vitamin biosynthetic process (GO:0042362)2.80959999
152regulation of respiratory burst (GO:0060263)2.80746266
153pyrimidine nucleoside catabolic process (GO:0046135)2.79812543
154hormone catabolic process (GO:0042447)2.78755984
155negative regulation of fibrinolysis (GO:0051918)2.78110327
156drug metabolic process (GO:0017144)2.77744229
157glycine metabolic process (GO:0006544)2.76458464
158branching involved in mammary gland duct morphogenesis (GO:0060444)2.76395225
159O-glycan processing (GO:0016266)2.76155323
160establishment of skin barrier (GO:0061436)2.75699124
161phenylpropanoid metabolic process (GO:0009698)2.75490535
162positive regulation of fatty acid biosynthetic process (GO:0045723)2.75418153
163sulfur compound transport (GO:0072348)2.72030997
164protein O-linked glycosylation (GO:0006493)2.71477993
165regulation of systemic arterial blood pressure (GO:0003073)2.71217818
166regulation of viral release from host cell (GO:1902186)2.70441927
167retinoic acid metabolic process (GO:0042573)2.68891737
168regulation of cholesterol metabolic process (GO:0090181)2.66265400
169digestion (GO:0007586)2.65889408
170glomerular epithelial cell development (GO:0072310)2.64690326
171glutathione metabolic process (GO:0006749)2.63953096
172positive regulation of fatty acid beta-oxidation (GO:0032000)2.63414995
173skeletal muscle adaptation (GO:0043501)2.62402685

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.29684013
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.28827186
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.66281816
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.56743374
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.71296003
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.60047367
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.44986931
8CDX2_20551321_ChIP-Seq_CACO-2_Human3.08929271
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.87486957
10SOX2_27498859_Chip-Seq_STOMACH_Mouse2.82723982
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.66547436
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.43206475
13STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.36331777
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.32866082
15ZNF263_19887448_ChIP-Seq_K562_Human2.32617265
16GATA4_25053715_ChIP-Seq_YYC3_Human2.31384520
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.29305865
18GATA6_25053715_ChIP-Seq_YYC3_Human2.16816531
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.08479970
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.83113146
21SMC4_20622854_ChIP-Seq_HELA_Human1.80726327
22KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.71671668
23* SOX2_20726797_ChIP-Seq_SW620_Human1.69504874
24CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.64335532
25* RACK7_27058665_Chip-Seq_MCF-7_Human1.62925109
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.61289289
27* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.59818532
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.56821243
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.56276821
30CTCF_27219007_Chip-Seq_Bcells_Human1.51705728
31AR_21909140_ChIP-Seq_LNCAP_Human1.50885039
32ATF3_27146783_Chip-Seq_COLON_Human1.48432181
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.48324362
34CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.47814437
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.47440580
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46222839
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45831429
38KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45200403
39* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44922637
40TP63_22573176_ChIP-Seq_HFKS_Human1.44666912
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44388847
42ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.43254865
43* TET1_21451524_ChIP-Seq_MESCs_Mouse1.42671314
44DROSHA_22980978_ChIP-Seq_HELA_Human1.41616892
45* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40680648
46ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.39658914
47CLOCK_20551151_ChIP-Seq_293T_Human1.39625522
48SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39089476
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35569498
50* RUNX1_27514584_Chip-Seq_MCF-7_Human1.31411091
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29950378
52SA1_27219007_Chip-Seq_ERYTHROID_Human1.29545443
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29137080
54BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.27932935
55FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.25471938
56LXR_22292898_ChIP-Seq_THP-1_Human1.25201405
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24570015
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24479226
59PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24234110
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23773761
61P63_26484246_Chip-Seq_KERATINOCYTES_Human1.23046566
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22473660
63GATA1_22025678_ChIP-Seq_K562_Human1.21396949
64* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20841899
65TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20704865
66AHR_22903824_ChIP-Seq_MCF-7_Human1.16656496
67E2F1_20622854_ChIP-Seq_HELA_Human1.16517886
68UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16198912
69SA1_27219007_Chip-Seq_Bcells_Human1.15376940
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15156356
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15044448
72FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14515026
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13773347
74* TCF7_22412390_ChIP-Seq_EML_Mouse1.13424083
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12914782
76KDM2B_26808549_Chip-Seq_K562_Human1.12819075
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11616178
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10438352
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09734667
80HNF4A_19822575_ChIP-Seq_HepG2_Human1.08688697
81TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08214240
82CTCF_20526341_ChIP-Seq_ESCs_Human1.06699954
83STAT1_20625510_ChIP-Seq_HELA_Human1.05617159
84RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04550885
85GATA3_24758297_ChIP-Seq_MCF-7_Human1.04161285
86VDR_21846776_ChIP-Seq_THP-1_Human1.03712380
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01851570
88EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01718127
89JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.01439894
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01250618
91EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.00795997
92IRF8_22096565_ChIP-ChIP_GC-B_Human0.99387851
93* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99224565
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99137658
95HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98988956
96FOXA2_19822575_ChIP-Seq_HepG2_Human0.98048711
97SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97542212
98SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97542212
99ELF1_20517297_ChIP-Seq_JURKAT_Human0.96718337
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96287875
101* RARB_24833708_ChIP-Seq_LIVER_Mouse0.95747001
102CREB1_26743006_Chip-Seq_LNCaP_Human0.95628950
103FOXA1_25552417_ChIP-Seq_VCAP_Human0.94305471
104YY1_22570637_ChIP-Seq_MALME-3M_Human0.94001521
105ESR1_20079471_ChIP-ChIP_T-47D_Human0.93996722
106* KLF5_25053715_ChIP-Seq_YYC3_Human0.92119301
107ELK3_25401928_ChIP-Seq_HUVEC_Human0.90658907
108TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89190745
109BCOR_27268052_Chip-Seq_Bcells_Human0.88586716
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88277030
111ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87924870
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87702596
113PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.87636780
114GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85415591
115FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85114102
116KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.84955381
117KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.84955381
118KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.84955381
119CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84069866
120NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83614193
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83600505
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83302597
123TRIM28_21343339_ChIP-Seq_HEK293_Human0.83285227
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81863156
125GATA2_22383799_ChIP-Seq_G1ME_Mouse0.81569781
126SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81517014
127* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.80898830
128GATA2_19941826_ChIP-Seq_K562_Human0.79472458
129SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78985394
130* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.77374037
131AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76675772
132E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.76528676
133PHF8_20622854_ChIP-Seq_HELA_Human0.75416820
134* P68_20966046_ChIP-Seq_HELA_Human0.75273428
135BCL6_27268052_Chip-Seq_Bcells_Human0.74208807

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.54836998
2MP0010234_abnormal_vibrissa_follicle4.99162298
3MP0002139_abnormal_hepatobiliary_system4.89303541
4MP0005085_abnormal_gallbladder_physiolo4.38774946
5MP0005365_abnormal_bile_salt3.66921454
6MP0001666_abnormal_nutrient_absorption3.64756852
7MP0004264_abnormal_extraembryonic_tissu3.25590538
8MP0003252_abnormal_bile_duct3.11434070
9MP0008875_abnormal_xenobiotic_pharmacok3.09650830
10MP0000566_synostosis2.97122204
11MP0003806_abnormal_nucleotide_metabolis2.83421938
12MP0009840_abnormal_foam_cell2.71215602
13MP0004043_abnormal_pH_regulation2.46185050
14MP0000678_abnormal_parathyroid_gland2.40448971
15MP0002796_impaired_skin_barrier2.34069651
16MP0010329_abnormal_lipoprotein_level2.25002290
17MP0002254_reproductive_system_inflammat2.24424989
18MP0003300_gastrointestinal_ulcer2.23603767
19MP0003866_abnormal_defecation2.16724737
20MP0001873_stomach_inflammation2.15078860
21MP0004019_abnormal_vitamin_homeostasis2.03052386
22MP0009780_abnormal_chondrocyte_physiolo2.02984245
23MP0003705_abnormal_hypodermis_morpholog2.01892060
24MP0003183_abnormal_peptide_metabolism1.99302163
25MP0005083_abnormal_biliary_tract1.98657896
26MP0005409_darkened_coat_color1.93277815
27MP0010155_abnormal_intestine_physiology1.89141136
28MP0010352_gastrointestinal_tract_polyps1.84496430
29MP0000537_abnormal_urethra_morphology1.77843580
30MP0000462_abnormal_digestive_system1.77651826
31MP0003191_abnormal_cellular_cholesterol1.75627095
32MP0002132_abnormal_respiratory_system1.74873323
33MP0002138_abnormal_hepatobiliary_system1.69601579
34MP0005501_abnormal_skin_physiology1.61437450
35MP0000477_abnormal_intestine_morphology1.57980670
36MP0010678_abnormal_skin_adnexa1.55776884
37MP0000490_abnormal_crypts_of1.52671691
38MP0002653_abnormal_ependyma_morphology1.49914697
39MP0005332_abnormal_amino_acid1.48764386
40MP0000609_abnormal_liver_physiology1.48739790
41MP0002249_abnormal_larynx_morphology1.46975766
42MP0008004_abnormal_stomach_pH1.46585031
43MP0001663_abnormal_digestive_system1.44476166
44MP0002098_abnormal_vibrissa_morphology1.44128682
45MP0003453_abnormal_keratinocyte_physiol1.43861703
46MP0009643_abnormal_urine_homeostasis1.43582156
47MP0003868_abnormal_feces_composition1.42791588
48MP0005076_abnormal_cell_differentiation1.42053593
49MP0005381_digestive/alimentary_phenotyp1.34453942
50MP0004858_abnormal_nervous_system1.33985426
51MP0002876_abnormal_thyroid_physiology1.22314476
52MP0001216_abnormal_epidermal_layer1.22110694
53MP0002277_abnormal_respiratory_mucosa1.21639339
54MP0002118_abnormal_lipid_homeostasis1.21513526
55MP0004947_skin_inflammation1.17869668
56MP0005319_abnormal_enzyme/_coenzyme1.17528675
57MP0004782_abnormal_surfactant_physiolog1.14955366
58MP0003566_abnormal_cell_adhesion1.14841253
59MP0001664_abnormal_digestion1.14756459
60MP0001849_ear_inflammation1.10078433
61MP0005377_hearing/vestibular/ear_phenot1.09879942
62MP0003878_abnormal_ear_physiology1.09879942
63MP0001346_abnormal_lacrimal_gland1.08163465
64MP0002060_abnormal_skin_morphology1.05794614
65MP0001764_abnormal_homeostasis1.05750455
66MP0006054_spinal_hemorrhage1.05351321
67MP0003283_abnormal_digestive_organ1.04128593
68MP0003879_abnormal_hair_cell0.96166823
69MP0005451_abnormal_body_composition0.95080994
70MP0001881_abnormal_mammary_gland0.93660280
71MP0005636_abnormal_mineral_homeostasis0.93491439
72MP0000377_abnormal_hair_follicle0.93034146
73MP0000681_abnormal_thyroid_gland0.91731593
74MP0000467_abnormal_esophagus_morphology0.91648539
75MP0005058_abnormal_lysosome_morphology0.91112189
76MP0004147_increased_porphyrin_level0.90323050
77MP0003693_abnormal_embryo_hatching0.88853529
78MP0000470_abnormal_stomach_morphology0.87726668
79MP0003718_maternal_effect0.87434963
80MP0005670_abnormal_white_adipose0.87366943
81MP0000383_abnormal_hair_follicle0.85726148
82MP0009379_abnormal_foot_pigmentation0.85443347
83MP0002166_altered_tumor_susceptibility0.83953778
84MP0009053_abnormal_anal_canal0.83609875
85MP0002009_preneoplasia0.83334841
86MP0005666_abnormal_adipose_tissue0.82474515
87MP0001188_hyperpigmentation0.79054291
88MP0004185_abnormal_adipocyte_glucose0.78318458
89MP0000598_abnormal_liver_morphology0.77983154
90MP0010771_integument_phenotype0.76795583
91MP0002136_abnormal_kidney_physiology0.75095796
92MP0001765_abnormal_ion_homeostasis0.74770887
93MP0005584_abnormal_enzyme/coenzyme_acti0.73965277
94MP0003941_abnormal_skin_development0.73340887
95MP0002896_abnormal_bone_mineralization0.72574061
96MP0003436_decreased_susceptibility_to0.71929023
97MP0005310_abnormal_salivary_gland0.71244913
98MP0003195_calcinosis0.70821624
99MP0001485_abnormal_pinna_reflex0.70362078
100MP0000538_abnormal_urinary_bladder0.70186455
101MP0002089_abnormal_postnatal_growth/wei0.68948438
102MP0005166_decreased_susceptibility_to0.67320147
103MP0002909_abnormal_adrenal_gland0.67204163
104MP0008469_abnormal_protein_level0.67043380
105MP0002822_catalepsy0.66781294
106MP0001756_abnormal_urination0.66768097
107MP0000613_abnormal_salivary_gland0.66385523
108MP0009785_altered_susceptibility_to0.64962321
109MP0001845_abnormal_inflammatory_respons0.64511634
110MP0005220_abnormal_exocrine_pancreas0.64387074
111MP0005408_hypopigmentation0.64340181
112MP0002006_tumorigenesis0.64327336
113MP0005023_abnormal_wound_healing0.63073155
114MP0010030_abnormal_orbit_morphology0.62807223
115MP0003315_abnormal_perineum_morphology0.62307922
116MP0008260_abnormal_autophagy0.61918944
117MP0004957_abnormal_blastocyst_morpholog0.61148675
118MP0005248_abnormal_Harderian_gland0.60529041
119MP0003638_abnormal_response/metabolism_0.60306114
120MP0004133_heterotaxia0.59873452
121MP0009931_abnormal_skin_appearance0.59868700
122MP0005165_increased_susceptibility_to0.58913561
123MP0003186_abnormal_redox_activity0.58163253
124MP0000579_abnormal_nail_morphology0.57117668
125MP0009642_abnormal_blood_homeostasis0.56886772
126MP0005025_abnormal_response_to0.55996086
127MP0000465_gastrointestinal_hemorrhage0.54169862
128MP0009765_abnormal_xenobiotic_induced0.53930454
129MP0000627_abnormal_mammary_gland0.52858965
130MP0005167_abnormal_blood-brain_barrier0.52640757
131MP0005647_abnormal_sex_gland0.52226606
132MP0005084_abnormal_gallbladder_morpholo0.49379569
133MP0008872_abnormal_physiological_respon0.49255874
134MP0005464_abnormal_platelet_physiology0.49021342

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.49062494
2Abnormal respiratory epithelium morphology (HP:0012253)7.28640932
3Abnormal respiratory motile cilium morphology (HP:0005938)7.28640932
4Abnormal respiratory motile cilium physiology (HP:0012261)7.27374898
5Absent/shortened dynein arms (HP:0200106)6.96295568
6Dynein arm defect of respiratory motile cilia (HP:0012255)6.96295568
7Abnormal ciliary motility (HP:0012262)6.95043130
8Chronic bronchitis (HP:0004469)6.78266745
9Rhinitis (HP:0012384)6.64929272
10Nasal polyposis (HP:0100582)5.46343320
11Intrahepatic cholestasis (HP:0001406)5.40485533
12Bronchiectasis (HP:0002110)5.36816379
13Right ventricular cardiomyopathy (HP:0011663)5.31650085
14Abnormality of monocarboxylic acid metabolism (HP:0010996)5.21815045
15Abnormality of the nasal mucosa (HP:0000433)4.80473904
16Hypobetalipoproteinemia (HP:0003563)4.66607186
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.54980196
18Ileus (HP:0002595)4.40877969
19Xanthomatosis (HP:0000991)4.34107723
20Malnutrition (HP:0004395)4.04392302
21Decreased circulating renin level (HP:0003351)3.98565424
22Abnormality of aromatic amino acid family metabolism (HP:0004338)3.94377561
23Abnormality of renin-angiotensin system (HP:0000847)3.76329201
24Deep venous thrombosis (HP:0002625)3.76118307
25Fat malabsorption (HP:0002630)3.66275531
26Hyperglycinuria (HP:0003108)3.56509081
27Pustule (HP:0200039)3.54331637
28Conjugated hyperbilirubinemia (HP:0002908)3.49912632
29Pili torti (HP:0003777)3.49881205
30Bronchitis (HP:0012387)3.43519379
31Hypolipoproteinemia (HP:0010981)3.41995236
32Hyperammonemia (HP:0001987)3.35747419
33Infertility (HP:0000789)3.28259079
34Abdominal distention (HP:0003270)3.24287095
35Hydroxyprolinuria (HP:0003080)3.10082781
36Abnormality of proline metabolism (HP:0010907)3.10082781
37Male infertility (HP:0003251)3.05795558
38Abnormality of chloride homeostasis (HP:0011422)3.05275360
39Abnormality of sulfur amino acid metabolism (HP:0004339)3.04995862
40Esophageal varix (HP:0002040)3.04021918
41Abnormality of glycine metabolism (HP:0010895)3.03352482
42Abnormality of serine family amino acid metabolism (HP:0010894)3.03352482
43Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.99512685
44Epidermoid cyst (HP:0200040)2.96301505
45Hypoglycemic coma (HP:0001325)2.90752535
46Prolonged partial thromboplastin time (HP:0003645)2.88902639
47Recurrent otitis media (HP:0000403)2.86954911
48Flat acetabular roof (HP:0003180)2.85183704
49Hyperlipoproteinemia (HP:0010980)2.81152926
50Hyperaldosteronism (HP:0000859)2.80735560
51Abnormality of purine metabolism (HP:0004352)2.76683411
52Onycholysis (HP:0001806)2.75992184
53Recurrent sinusitis (HP:0011108)2.75702193
54Alkalosis (HP:0001948)2.69816417
55Chronic sinusitis (HP:0011109)2.67756094
56Hyperglycinemia (HP:0002154)2.67413819
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.67297373
58Acanthocytosis (HP:0001927)2.66837463
59Woolly hair (HP:0002224)2.65642389
60Hypoalphalipoproteinemia (HP:0003233)2.65161621
61Hyperkalemia (HP:0002153)2.65127151
62Abnormal hair laboratory examination (HP:0003328)2.62954039
63Abnormality of nucleobase metabolism (HP:0010932)2.61616345
64Atelectasis (HP:0100750)2.61250230
65Complement deficiency (HP:0004431)2.61057366
66Renal salt wasting (HP:0000127)2.60899073
67Hyponatremia (HP:0002902)2.60756219
68Abnormality of dicarboxylic acid metabolism (HP:0010995)2.51929468
69Dicarboxylic aciduria (HP:0003215)2.51929468
70Villous atrophy (HP:0011473)2.50682879
71Abnormality of small intestinal villus morphology (HP:0011472)2.50682879
72Abnormal cartilage morphology (HP:0002763)2.49575512
73Plantar hyperkeratosis (HP:0007556)2.48999619
74Fragile nails (HP:0001808)2.47730524
75Abnormal tarsal ossification (HP:0008369)2.47508505
76Gout (HP:0001997)2.43753764
77Hypercholesterolemia (HP:0003124)2.41082354
78Hyperactive renin-angiotensin system (HP:0000841)2.39839905
79Abnormality of the distal phalanges of the toes (HP:0010182)2.37382796
80Milia (HP:0001056)2.35946632
81Alopecia of scalp (HP:0002293)2.35786104
82Late onset (HP:0003584)2.35169440
83Ketosis (HP:0001946)2.33756422
84Micronodular cirrhosis (HP:0001413)2.32804282
85Abnormality of pyrimidine metabolism (HP:0004353)2.31482211
86Abnormality of fatty-acid metabolism (HP:0004359)2.31373904
87Vertebral clefting (HP:0008428)2.26097128
88Vascular calcification (HP:0004934)2.25288893
89Dehydration (HP:0001944)2.25207468
90Thin bony cortex (HP:0002753)2.24582493
91Biliary tract neoplasm (HP:0100574)2.23805631
92Steatorrhea (HP:0002570)2.22530262
93Bell-shaped thorax (HP:0001591)2.19307199
94Abnormality of vitamin metabolism (HP:0100508)2.17818383
95Abnormal biliary tract morphology (HP:0012440)2.17302941
96Abnormality of the common coagulation pathway (HP:0010990)2.17299415
97Widely patent fontanelles and sutures (HP:0004492)2.15621841
98Tubulointerstitial nephritis (HP:0001970)2.14834235
99Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.14599435
100Chronic otitis media (HP:0000389)2.13477863
101Abnormality of the intrinsic pathway (HP:0010989)2.12387558
102Hyperbilirubinemia (HP:0002904)2.10938709
103Abnormality of complement system (HP:0005339)2.10611433
104Distal lower limb muscle weakness (HP:0009053)2.09274415
105Cheilitis (HP:0100825)2.08011496
106Abnormality of the gastric mucosa (HP:0004295)2.07904908
107Hypotension (HP:0002615)2.07524110
108Metabolic alkalosis (HP:0200114)2.07170328
109Amelogenesis imperfecta (HP:0000705)2.04778137
110Pancreatitis (HP:0001733)2.02103620
111Stridor (HP:0010307)2.01125533
112Metabolic acidosis (HP:0001942)2.00662013
113Flattened epiphyses (HP:0003071)2.00611022
114Spinal cord compression (HP:0002176)2.00267830
115Spastic diplegia (HP:0001264)1.99916960
116Distal upper limb amyotrophy (HP:0007149)1.98781162
117Upper limb amyotrophy (HP:0009129)1.98781162
118Lethargy (HP:0001254)1.97943382
119Curly hair (HP:0002212)1.97832668
120Hyperphosphatemia (HP:0002905)1.95293939
121Ketoacidosis (HP:0001993)1.94488252
122Myocardial infarction (HP:0001658)1.91751133
123Cardiovascular calcification (HP:0011915)1.91676876
124Occipital encephalocele (HP:0002085)1.91503344
125Congenital ichthyosiform erythroderma (HP:0007431)1.91499692
126Gastrointestinal dysmotility (HP:0002579)1.90658638
127Abnormality of sodium homeostasis (HP:0010931)1.89074923
128Joint hemorrhage (HP:0005261)1.88862461
129Increased purine levels (HP:0004368)1.87570651
130Hyperuricemia (HP:0002149)1.87570651
131Glycosuria (HP:0003076)1.85441886
132Abnormality of urine glucose concentration (HP:0011016)1.85441886
133Abnormal foot bone ossification (HP:0010675)1.83657579
134Abnormal vertebral ossification (HP:0100569)1.82497064
135Hemorrhage of the eye (HP:0011885)1.82134686
136Cone-rod dystrophy (HP:0000548)1.81480663
137Hyperparathyroidism (HP:0000843)1.81390806
138Renal tubular acidosis (HP:0001947)1.80523991
139Abnormal hemoglobin (HP:0011902)1.79924348
140Abnormality of the dental root (HP:0006486)1.79875808
141Taurodontia (HP:0000679)1.79875808
142Abnormality of permanent molar morphology (HP:0011071)1.79875808
143Abnormality of transition element cation homeostasis (HP:0011030)1.78317259
144Hepatocellular carcinoma (HP:0001402)1.77902103
145Abnormality of methionine metabolism (HP:0010901)1.77410264
146Rectal prolapse (HP:0002035)1.77252900
147Abnormality of the 1st metacarpal (HP:0010009)1.76974141
148Hand muscle atrophy (HP:0009130)1.76701166
149Glomerulosclerosis (HP:0000096)1.76571597
150Abnormal enzyme/coenzyme activity (HP:0012379)1.76429158
151Proximal tubulopathy (HP:0000114)1.76206375
152Palpitations (HP:0001962)1.76148608
153Posterior subcapsular cataract (HP:0007787)1.75474543
154Poikilocytosis (HP:0004447)1.75457408
155Abnormality of carpal bone ossification (HP:0006257)1.75336236
156Chronic diarrhea (HP:0002028)1.74433275
157Adrenal overactivity (HP:0002717)1.73281402
158Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.73213513
159Focal segmental glomerulosclerosis (HP:0000097)1.72435034
160Diaphragmatic weakness (HP:0009113)1.69147465
161Abnormality of the distal phalanx of the thumb (HP:0009617)1.67452746
162Progressive sensorineural hearing impairment (HP:0000408)1.63822467
163Bronchomalacia (HP:0002780)1.63344830
164Lip pit (HP:0100267)1.61519568
165Abnormality of potassium homeostasis (HP:0011042)1.61095150
166Abnormality of molar (HP:0011077)1.60924632
167Abnormality of molar morphology (HP:0011070)1.60924632
168Abnormality of the dental pulp (HP:0006479)1.60662368
169Cervical subluxation (HP:0003308)1.59082069
170Mildly elevated creatine phosphokinase (HP:0008180)1.59074199
171Growth hormone excess (HP:0000845)1.57715186
172Wide cranial sutures (HP:0010537)1.57658826
173Bifid scrotum (HP:0000048)1.53882283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.73690864
2MST1R4.41467535
3MST44.03467175
4TAOK33.26458589
5MAP2K23.20821422
6SMG12.93360882
7PIK3CA2.77428795
8FRK2.75291785
9ERN12.44841977
10EPHB22.25176271
11LMTK22.25114846
12NUAK12.15303092
13PTK62.10638551
14EEF2K1.88960168
15STK38L1.88881806
16GRK61.85278551
17MAP3K101.85036833
18PKN21.81127678
19BCKDK1.78764952
20RPS6KB21.78360153
21FGFR41.65583394
22STK391.64978633
23MAP3K21.63353584
24SIK11.60687791
25ACVR1B1.59102623
26MAP3K71.58704140
27PRKG21.55123284
28TRIB31.53825131
29RIPK11.49223562
30NME11.48279405
31MET1.46948395
32MAPKAPK31.28151026
33STK241.26729725
34STK101.18469594
35SCYL21.17745601
36MAP2K61.15438399
37PAK41.15200112
38LRRK21.12970337
39MATK1.12577342
40NEK61.11540281
41TAOK11.09977894
42ERBB21.08868563
43MAP2K11.08571206
44FLT31.03638184
45EPHB11.02500661
46MUSK1.00611940
47TESK20.98752516
48MAP3K80.97785335
49OXSR10.96962676
50MAP3K30.95454984
51FER0.94354202
52PTK20.93574383
53KSR20.92475826
54PRKCI0.89862348
55LATS10.88796061
56MAP3K110.88688700
57TYK20.88180245
58ERBB40.88135148
59DMPK0.86133350
60MAP3K120.85949750
61MAPK110.84956145
62TTK0.83130123
63TESK10.82308249
64WNK40.80666472
65TEC0.79434778
66CDK60.77853251
67TBK10.77081564
68PIK3CG0.72472284
69MAP4K10.70912172
70MAP3K10.70810370
71CSK0.64969544
72RPS6KA20.64687931
73NME20.63092765
74CDK40.62650396
75MAPK150.61711740
76AURKB0.61604431
77CDC42BPA0.58533989
78PBK0.57607714
79MYLK0.56050210
80ILK0.55805947
81RAF10.52017435
82MAP3K60.50717386
83PRKAA20.50328028
84KDR0.50122565
85RET0.48745841
86DYRK1B0.48554262
87MARK20.47828911
88MAP2K30.46013042
89EPHA30.45360227
90JAK20.44273943
91DDR20.44258553
92IRAK30.41844652
93CDK120.41823655
94FGFR30.41640247
95CAMK2G0.41639770
96BTK0.40142940
97PRKD20.38817389
98TRPM70.38307418
99NEK20.37504690
100PDPK10.35713183
101IKBKE0.32550579
102ZAP700.31619412
103MAP3K140.31528899
104CHUK0.31344197
105ICK0.30534905
106RPS6KC10.30327100
107RPS6KL10.30327100
108NLK0.30124950
109MAPKAPK20.29002710
110PRPF4B0.28556015
111PRKCD0.28377943
112ITK0.28111876
113HIPK20.27193427
114PAK10.27122971
115MTOR0.26530017
116CDK70.26110113
117SRC0.26091233
118AKT20.25528923
119BMX0.24074390
120STK380.23772563
121GRK10.23716435
122NEK10.23602932
123BLK0.23299376
124TGFBR20.22538333
125NEK90.22445288
126GSK3A0.21490785
127RPS6KA40.21209634
128PRKCZ0.21122205
129PDK10.20324062
130ABL20.20135909
131RPS6KA60.19591575
132DYRK30.17787971
133IRAK10.17609751
134CAMK2D0.15971117
135MELK0.15763884

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.32358978
2Fat digestion and absorption_Homo sapiens_hsa049753.07195005
3Sulfur metabolism_Homo sapiens_hsa009202.95391385
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.72451239
5Nitrogen metabolism_Homo sapiens_hsa009102.51370565
6Histidine metabolism_Homo sapiens_hsa003402.40985406
7Tryptophan metabolism_Homo sapiens_hsa003802.39143171
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.35211826
9Caffeine metabolism_Homo sapiens_hsa002322.35190787
10Fatty acid degradation_Homo sapiens_hsa000712.29004041
11Arginine biosynthesis_Homo sapiens_hsa002202.12406634
12Folate biosynthesis_Homo sapiens_hsa007902.09796079
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08549425
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.04044252
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.97913328
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.96901352
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.84671468
18Bile secretion_Homo sapiens_hsa049761.82146518
19Chemical carcinogenesis_Homo sapiens_hsa052041.80546657
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.77509980
21Vitamin digestion and absorption_Homo sapiens_hsa049771.76141037
22Mineral absorption_Homo sapiens_hsa049781.75924873
23PPAR signaling pathway_Homo sapiens_hsa033201.59834128
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.57840464
25Butanoate metabolism_Homo sapiens_hsa006501.53034580
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.52269391
27Galactose metabolism_Homo sapiens_hsa000521.50703352
28Selenocompound metabolism_Homo sapiens_hsa004501.50140809
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49810966
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.48027540
31Glutathione metabolism_Homo sapiens_hsa004801.47035308
32beta-Alanine metabolism_Homo sapiens_hsa004101.45762068
33Retinol metabolism_Homo sapiens_hsa008301.42933725
34Starch and sucrose metabolism_Homo sapiens_hsa005001.39563376
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.38673147
36Complement and coagulation cascades_Homo sapiens_hsa046101.38221717
37Peroxisome_Homo sapiens_hsa041461.36211648
38Pyruvate metabolism_Homo sapiens_hsa006201.34599441
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33143251
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.32242938
41Fructose and mannose metabolism_Homo sapiens_hsa000511.30558989
42Pentose phosphate pathway_Homo sapiens_hsa000301.25948920
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25723055
44Fatty acid metabolism_Homo sapiens_hsa012121.25541984
45Carbon metabolism_Homo sapiens_hsa012001.23586061
46Propanoate metabolism_Homo sapiens_hsa006401.22881800
47ABC transporters_Homo sapiens_hsa020101.21173604
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18121838
49Sulfur relay system_Homo sapiens_hsa041221.17266707
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.15739176
51Renin-angiotensin system_Homo sapiens_hsa046141.12506286
52Tyrosine metabolism_Homo sapiens_hsa003501.08768469
53Glycerolipid metabolism_Homo sapiens_hsa005611.08404183
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05090568
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04178719
56Arginine and proline metabolism_Homo sapiens_hsa003301.03272073
57Phenylalanine metabolism_Homo sapiens_hsa003600.99858538
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97625340
59Biosynthesis of amino acids_Homo sapiens_hsa012300.94845102
60Staphylococcus aureus infection_Homo sapiens_hsa051500.93256951
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92364780
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91383018
63Linoleic acid metabolism_Homo sapiens_hsa005910.88500690
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.85764357
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79989689
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79369133
67Notch signaling pathway_Homo sapiens_hsa043300.78266513
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75512227
69Fatty acid elongation_Homo sapiens_hsa000620.73058232
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72086572
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70341425
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59035621
73Bladder cancer_Homo sapiens_hsa052190.58947254
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58413777
75Protein digestion and absorption_Homo sapiens_hsa049740.58324201
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57592234
77Steroid biosynthesis_Homo sapiens_hsa001000.54304011
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.49043144
79Adherens junction_Homo sapiens_hsa045200.48168744
80Arachidonic acid metabolism_Homo sapiens_hsa005900.47999586
81Lysine degradation_Homo sapiens_hsa003100.47941419
82Metabolic pathways_Homo sapiens_hsa011000.47694086
83Vibrio cholerae infection_Homo sapiens_hsa051100.46456953
84Fatty acid biosynthesis_Homo sapiens_hsa000610.46419870
85* Tight junction_Homo sapiens_hsa045300.45938967
86Thyroid cancer_Homo sapiens_hsa052160.43953668
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.43367449
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.41260038
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40787957
90Hepatitis C_Homo sapiens_hsa051600.40159351
91Choline metabolism in cancer_Homo sapiens_hsa052310.39825930
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37967215
93Other glycan degradation_Homo sapiens_hsa005110.34941675
94Ribosome_Homo sapiens_hsa030100.34699853
95AMPK signaling pathway_Homo sapiens_hsa041520.34297768
96One carbon pool by folate_Homo sapiens_hsa006700.32323927
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29636218
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29348181
99Endometrial cancer_Homo sapiens_hsa052130.29179310
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28588909
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28453819
102Thyroid hormone synthesis_Homo sapiens_hsa049180.27877913
103Insulin signaling pathway_Homo sapiens_hsa049100.27036075
104Inositol phosphate metabolism_Homo sapiens_hsa005620.23372327
105Pancreatic secretion_Homo sapiens_hsa049720.23304348
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23229247
107Insulin resistance_Homo sapiens_hsa049310.22730956
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21948681
109Endocytosis_Homo sapiens_hsa041440.20452573
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.17783008
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.14608594
112Sphingolipid metabolism_Homo sapiens_hsa006000.14439315
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.14036239
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.13885927
115Acute myeloid leukemia_Homo sapiens_hsa052210.13617961
116Lysosome_Homo sapiens_hsa041420.13330981
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.11421723
118Toxoplasmosis_Homo sapiens_hsa051450.11209040
119Glucagon signaling pathway_Homo sapiens_hsa049220.09209976
120Ether lipid metabolism_Homo sapiens_hsa005650.08852282
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.08286530
122N-Glycan biosynthesis_Homo sapiens_hsa005100.08085828

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