TK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.81686076
2telomere maintenance via semi-conservative replication (GO:0032201)5.74714537
3DNA strand elongation (GO:0022616)5.53343703
4telomere maintenance via recombination (GO:0000722)5.15176816
5DNA replication initiation (GO:0006270)5.12665562
6DNA replication checkpoint (GO:0000076)5.01002903
7mitotic recombination (GO:0006312)4.99940054
8establishment of integrated proviral latency (GO:0075713)4.76618614
9protein localization to kinetochore (GO:0034501)4.70831663
10DNA unwinding involved in DNA replication (GO:0006268)4.68910904
11regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.43741210
12telomere maintenance via telomere lengthening (GO:0010833)4.37963389
13nucleotide-excision repair, DNA gap filling (GO:0006297)4.34293700
14CENP-A containing nucleosome assembly (GO:0034080)4.31998971
15ribosomal small subunit assembly (GO:0000028)4.30582056
16maturation of SSU-rRNA (GO:0030490)4.26463248
17DNA deamination (GO:0045006)4.23288975
18chromatin remodeling at centromere (GO:0031055)4.21108384
19nucleobase biosynthetic process (GO:0046112)4.12439957
20establishment of viral latency (GO:0019043)4.10684295
21protein localization to chromosome, centromeric region (GO:0071459)4.08169777
22mitotic metaphase plate congression (GO:0007080)4.08105690
23nucleobase-containing small molecule interconversion (GO:0015949)4.01677481
24kinetochore organization (GO:0051383)4.01624126
25purine nucleobase biosynthetic process (GO:0009113)3.94659728
26DNA replication-independent nucleosome organization (GO:0034724)3.94467183
27DNA replication-independent nucleosome assembly (GO:0006336)3.94467183
28DNA replication-dependent nucleosome assembly (GO:0006335)3.92344499
29DNA replication-dependent nucleosome organization (GO:0034723)3.92344499
30kinetochore assembly (GO:0051382)3.78374376
31viral transcription (GO:0019083)3.67788509
32ribosomal small subunit biogenesis (GO:0042274)3.65424480
33translational termination (GO:0006415)3.60830242
34folic acid-containing compound biosynthetic process (GO:0009396)3.60588908
35protein maturation by protein folding (GO:0022417)3.57656829
36formation of translation preinitiation complex (GO:0001731)3.56558586
37attachment of spindle microtubules to kinetochore (GO:0008608)3.56012674
38mitotic nuclear envelope disassembly (GO:0007077)3.54736444
39metaphase plate congression (GO:0051310)3.47795125
40regulation of double-strand break repair via homologous recombination (GO:0010569)3.39788246
41chromosome condensation (GO:0030261)3.39522366
42deoxyribonucleotide biosynthetic process (GO:0009263)3.37037674
43histone exchange (GO:0043486)3.36933013
44folic acid metabolic process (GO:0046655)3.36816656
45deoxyribose phosphate biosynthetic process (GO:0046385)3.35983289
462-deoxyribonucleotide biosynthetic process (GO:0009265)3.35983289
47ribosomal large subunit biogenesis (GO:0042273)3.35982951
48mitotic chromosome condensation (GO:0007076)3.34532226
49proteasome assembly (GO:0043248)3.33653280
50mitotic sister chromatid segregation (GO:0000070)3.32927164
51regulation of cellular amino acid metabolic process (GO:0006521)3.31590634
52transcription-coupled nucleotide-excision repair (GO:0006283)3.31081631
53signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.30698859
54intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.30698859
55IMP biosynthetic process (GO:0006188)3.29089303
56regulation of mitotic spindle organization (GO:0060236)3.29049660
57telomere maintenance (GO:0000723)3.29017293
58DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.28936189
59signal transduction involved in DNA damage checkpoint (GO:0072422)3.28804396
60signal transduction involved in DNA integrity checkpoint (GO:0072401)3.28804396
61positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.28779235
62telomere organization (GO:0032200)3.28661638
63nuclear pore complex assembly (GO:0051292)3.28505227
64translational elongation (GO:0006414)3.28462952
65signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.28180869
66signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.28180869
67signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.28180869
68DNA ligation (GO:0006266)3.27640805
69establishment of chromosome localization (GO:0051303)3.25357040
70translational initiation (GO:0006413)3.23011350
71ribosome assembly (GO:0042255)3.22888560
72nuclear envelope reassembly (GO:0031468)3.22818675
73mitotic nuclear envelope reassembly (GO:0007084)3.22818675
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.22680103
75nuclear envelope disassembly (GO:0051081)3.21324699
76membrane disassembly (GO:0030397)3.21324699
77signal transduction involved in cell cycle checkpoint (GO:0072395)3.21205506
78ribonucleoprotein complex biogenesis (GO:0022613)3.21083910
79regulation of spindle organization (GO:0090224)3.18286935
80* deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.17652065
81chromosome segregation (GO:0007059)3.17167021
82regulation of ubiquitin-protein transferase activity (GO:0051438)3.16133730
83cell cycle G1/S phase transition (GO:0044843)3.14678590
84G1/S transition of mitotic cell cycle (GO:0000082)3.14678590
85positive regulation of ligase activity (GO:0051351)3.13510746
86regulation of mitochondrial translation (GO:0070129)3.12168091
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.11619327
88proline biosynthetic process (GO:0006561)3.10303908
89regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.09970369
90rRNA processing (GO:0006364)3.08305309
91SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.08190436
92spliceosomal snRNP assembly (GO:0000387)3.08134622
93regulation of chromosome segregation (GO:0051983)3.07520452
94ribosome biogenesis (GO:0042254)3.04766481
95positive regulation of chromosome segregation (GO:0051984)3.04382028
96rRNA modification (GO:0000154)3.03775194
97regulation of ligase activity (GO:0051340)3.03739292
98heterochromatin organization (GO:0070828)3.02526650
99regulation of translational fidelity (GO:0006450)3.02505527
100nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.01672233
101positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.01016704
102meiotic chromosome segregation (GO:0045132)3.00901494
103regulation of translational termination (GO:0006449)3.00826043
104chromatin assembly or disassembly (GO:0006333)2.99771286
105translesion synthesis (GO:0019985)2.99290920
106sister chromatid segregation (GO:0000819)2.97943778
107cotranslational protein targeting to membrane (GO:0006613)2.97906229
108protein targeting to ER (GO:0045047)2.97040719
109DNA duplex unwinding (GO:0032508)2.97006892
110protein complex localization (GO:0031503)2.96897422
111rRNA metabolic process (GO:0016072)2.96629375
112pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.96583459
113DNA geometric change (GO:0032392)2.96466976
114DNA packaging (GO:0006323)2.95607788
115mismatch repair (GO:0006298)2.94599924
116regulation of nuclear cell cycle DNA replication (GO:0033262)2.94422109
117spindle checkpoint (GO:0031577)2.94129539
118pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.93958451
119Golgi transport vesicle coating (GO:0048200)2.93939649
120COPI coating of Golgi vesicle (GO:0048205)2.93939649
121DNA synthesis involved in DNA repair (GO:0000731)2.90938086
122histone-serine phosphorylation (GO:0035404)2.90676900
123maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.90048062
124DNA replication (GO:0006260)2.88939831
125L-serine metabolic process (GO:0006563)2.88462542
126DNA topological change (GO:0006265)2.88386327
127pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.87948408
128viral mRNA export from host cell nucleus (GO:0046784)2.87557905
129regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.87221275
130nuclear pore organization (GO:0006999)2.86573507
131pseudouridine synthesis (GO:0001522)2.84739164
132positive regulation of DNA-dependent DNA replication (GO:2000105)2.84724564
133protein K6-linked ubiquitination (GO:0085020)2.84611694
134DNA-dependent DNA replication (GO:0006261)2.84303562
135cellular protein complex disassembly (GO:0043624)2.83547270
136mitotic cell cycle (GO:0000278)2.82777388
137negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.82609687
138negative regulation of ligase activity (GO:0051352)2.82609687
139viral life cycle (GO:0019058)2.81719680
140base-excision repair (GO:0006284)2.80669907
141negative regulation of chromosome segregation (GO:0051985)2.80611266
142protein localization to endoplasmic reticulum (GO:0070972)2.79915004
143establishment of protein localization to endoplasmic reticulum (GO:0072599)2.79857696
144negative regulation of sister chromatid segregation (GO:0033046)2.79180814
145negative regulation of mitotic sister chromatid segregation (GO:0033048)2.79180814

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.69314810
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.32737814
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.85725512
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.85567805
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.63399634
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.31283164
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.23947839
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.75833581
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.72354369
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.71641674
11* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.71166230
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.63031277
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61007856
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.60322104
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.51040886
16AR_21909140_ChIP-Seq_LNCAP_Human2.35755404
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23707278
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21309891
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17758472
20* XRN2_22483619_ChIP-Seq_HELA_Human2.17309513
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.12868144
22VDR_23849224_ChIP-Seq_CD4+_Human2.07721716
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07584216
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01525438
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97333773
26* DCP1A_22483619_ChIP-Seq_HELA_Human1.91024952
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88918345
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.87113562
29FOXP3_21729870_ChIP-Seq_TREG_Human1.86994520
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85778777
31* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83993750
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.69111887
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69038840
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.68314370
35GABP_19822575_ChIP-Seq_HepG2_Human1.68273174
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65331965
37TTF2_22483619_ChIP-Seq_HELA_Human1.64986243
38ZNF263_19887448_ChIP-Seq_K562_Human1.60527952
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59514584
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55910247
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55283084
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54111046
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53233467
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.52452569
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50891310
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44854584
47CIITA_25753668_ChIP-Seq_RAJI_Human1.44645167
48ELK1_19687146_ChIP-ChIP_HELA_Human1.43821041
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42963468
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42558039
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.42154146
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36103276
53* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35720797
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35540475
55MYC_22102868_ChIP-Seq_BL_Human1.32690426
56KDM5A_27292631_Chip-Seq_BREAST_Human1.30602777
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30217645
58* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29267356
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29088829
60* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27576480
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25411559
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24913264
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22200677
64VDR_21846776_ChIP-Seq_THP-1_Human1.19179780
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18361415
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17331622
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16745632
68* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15799219
69CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15579229
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15351513
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15277008
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08496042
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04481740
74SPI1_23547873_ChIP-Seq_NB4_Human1.02923179
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00923112
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00330172
77TP63_19390658_ChIP-ChIP_HaCaT_Human0.99419437
78NOTCH1_21737748_ChIP-Seq_TLL_Human0.98820886
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98672043
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98634700
81SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98300934
82CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97785429
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97259029
84TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97250507
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97115864
86* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96185917
87PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96154934
88* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94677962
89TFEB_21752829_ChIP-Seq_HELA_Human0.94429682
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93674724
91ATF3_27146783_Chip-Seq_COLON_Human0.93317346
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93180789
93* TET1_21451524_ChIP-Seq_MESCs_Mouse0.92368966
94SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91892664
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91027622
96* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90439439
97TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90126374
98RACK7_27058665_Chip-Seq_MCF-7_Human0.89093132
99MYC_18940864_ChIP-ChIP_HL60_Human0.88801919
100ELK3_25401928_ChIP-Seq_HUVEC_Human0.88791767
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88718108
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87731411
103SOX17_20123909_ChIP-Seq_XEN_Mouse0.87689009
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86474555
105IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.86099359
106CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85421550
107TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.85263780
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84976333
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84355081
110* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83517764
111SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82435381
112ELK1_22589737_ChIP-Seq_MCF10A_Human0.79222622
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.77886845
114* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77773847
115TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.77376524
116CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.76745438
117IRF8_21731497_ChIP-ChIP_J774_Mouse0.74232531
118IRF8_22096565_ChIP-ChIP_GC-B_Human0.72033455
119OCT4_18692474_ChIP-Seq_MEFs_Mouse0.70473273
120MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.68217291

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.27023893
2MP0003111_abnormal_nucleus_morphology4.71734806
3MP0010094_abnormal_chromosome_stability4.49478952
4MP0004957_abnormal_blastocyst_morpholog4.15804515
5MP0003077_abnormal_cell_cycle3.76961956
6MP0008057_abnormal_DNA_replication3.67499897
7MP0002877_abnormal_melanocyte_morpholog3.06791871
8MP0008058_abnormal_DNA_repair2.94078311
9MP0002396_abnormal_hematopoietic_system2.66430174
10MP0008932_abnormal_embryonic_tissue2.62192801
11MP0010352_gastrointestinal_tract_polyps2.59305007
12MP0008007_abnormal_cellular_replicative2.40550030
13MP0003705_abnormal_hypodermis_morpholog1.93319865
14MP0003718_maternal_effect1.92119132
15MP0003806_abnormal_nucleotide_metabolis1.86138905
16MP0000372_irregular_coat_pigmentation1.84390211
17MP0003786_premature_aging1.84313781
18MP0000490_abnormal_crypts_of1.83316958
19MP0000350_abnormal_cell_proliferation1.81947438
20MP0001730_embryonic_growth_arrest1.81504070
21MP0010234_abnormal_vibrissa_follicle1.69899768
22MP0010307_abnormal_tumor_latency1.67109061
23MP0004233_abnormal_muscle_weight1.58058362
24MP0005501_abnormal_skin_physiology1.57566132
25MP0009333_abnormal_splenocyte_physiolog1.56628153
26MP0004808_abnormal_hematopoietic_stem1.56326203
27MP0002019_abnormal_tumor_incidence1.47030639
28MP0003186_abnormal_redox_activity1.45726549
29MP0005397_hematopoietic_system_phenotyp1.45529409
30MP0001545_abnormal_hematopoietic_system1.45529409
31MP0001672_abnormal_embryogenesis/_devel1.39964610
32MP0005380_embryogenesis_phenotype1.39964610
33MP0003123_paternal_imprinting1.39366576
34MP0000313_abnormal_cell_death1.38439065
35MP0005171_absent_coat_pigmentation1.34819797
36MP0003566_abnormal_cell_adhesion1.33425318
37MP0005257_abnormal_intraocular_pressure1.33134963
38MP0006036_abnormal_mitochondrial_physio1.29738754
39MP0002080_prenatal_lethality1.28764121
40MP0000537_abnormal_urethra_morphology1.26690197
41MP0009840_abnormal_foam_cell1.25078517
42MP0004185_abnormal_adipocyte_glucose1.25040249
43MP0001697_abnormal_embryo_size1.24870026
44MP0001835_abnormal_antigen_presentation1.24688090
45MP0001346_abnormal_lacrimal_gland1.24541423
46MP0002796_impaired_skin_barrier1.23154518
47MP0003984_embryonic_growth_retardation1.23016910
48MP0002398_abnormal_bone_marrow1.22945969
49MP0003763_abnormal_thymus_physiology1.21314543
50MP0002088_abnormal_embryonic_growth/wei1.20624071
51MP0008877_abnormal_DNA_methylation1.20310279
52MP0002722_abnormal_immune_system1.19790649
53MP0000689_abnormal_spleen_morphology1.18848350
54MP0003950_abnormal_plasma_membrane1.18492229
55MP0008260_abnormal_autophagy1.17874928
56MP0003567_abnormal_fetal_cardiomyocyte1.17788689
57MP0003656_abnormal_erythrocyte_physiolo1.16489290
58MP0001853_heart_inflammation1.14058070
59MP0001727_abnormal_embryo_implantation1.10649236
60MP0002086_abnormal_extraembryonic_tissu1.08854407
61MP0000703_abnormal_thymus_morphology1.08179320
62MP0002060_abnormal_skin_morphology1.06260472
63MP0002132_abnormal_respiratory_system1.05261296
64MP0002429_abnormal_blood_cell1.02053265
65MP0000858_altered_metastatic_potential1.01522529
66MP0002085_abnormal_embryonic_tissue1.00809579
67MP0001881_abnormal_mammary_gland0.96960636
68MP0003315_abnormal_perineum_morphology0.95432430
69MP0001800_abnormal_humoral_immune0.94117764
70MP0005075_abnormal_melanosome_morpholog0.93613486
71MP0000678_abnormal_parathyroid_gland0.92408436
72MP0005330_cardiomyopathy0.91153856
73MP0004147_increased_porphyrin_level0.90576858
74MP0000716_abnormal_immune_system0.89242311
75MP0000685_abnormal_immune_system0.89067080
76MP0000015_abnormal_ear_pigmentation0.88954612
77MP0008438_abnormal_cutaneous_collagen0.87751050
78MP0009278_abnormal_bone_marrow0.87344633
79MP0004197_abnormal_fetal_growth/weight/0.86527287
80MP0005623_abnormal_meninges_morphology0.86148940
81MP0002452_abnormal_antigen_presenting0.85544668
82MP0006292_abnormal_olfactory_placode0.84372705
83MP0002210_abnormal_sex_determination0.83896864
84MP0002938_white_spotting0.83883350
85MP0005058_abnormal_lysosome_morphology0.83563575
86MP0001661_extended_life_span0.83372510
87MP0010030_abnormal_orbit_morphology0.81543434
88MP0002420_abnormal_adaptive_immunity0.80975323
89MP0001819_abnormal_immune_cell0.80222510
90MP0009379_abnormal_foot_pigmentation0.80201529
91MP0000358_abnormal_cell_content/0.79512286
92MP0001849_ear_inflammation0.78701594
93MP0006054_spinal_hemorrhage0.77549323
94MP0001216_abnormal_epidermal_layer0.77268420
95MP0002084_abnormal_developmental_patter0.77125539
96MP0001119_abnormal_female_reproductive0.76280671
97MP0005671_abnormal_response_to0.75600022
98MP0005076_abnormal_cell_differentiation0.75014907
99MP0009697_abnormal_copulation0.74824375
100MP0001145_abnormal_male_reproductive0.74293763
101MP0003436_decreased_susceptibility_to0.73421182
102MP0005025_abnormal_response_to0.73357288
103MP0002723_abnormal_immune_serum0.73187319
104MP0002163_abnormal_gland_morphology0.72101367
105MP0000627_abnormal_mammary_gland0.71536090
106MP0001764_abnormal_homeostasis0.71409465
107MP0003453_abnormal_keratinocyte_physiol0.71232566
108MP0002111_abnormal_tail_morphology0.71116135
109MP0002405_respiratory_system_inflammati0.70952038
110MP0000762_abnormal_tongue_morphology0.69406012
111MP0005023_abnormal_wound_healing0.69078979
112MP0001186_pigmentation_phenotype0.68676271
113MP0005389_reproductive_system_phenotype0.68468839
114MP0005621_abnormal_cell_physiology0.68315922
115MP0000477_abnormal_intestine_morphology0.68250268
116MP0005384_cellular_phenotype0.67992484
117MP0009785_altered_susceptibility_to0.67675216
118MP0003941_abnormal_skin_development0.67402726
119MP0000465_gastrointestinal_hemorrhage0.66441842
120MP0001293_anophthalmia0.66401005
121MP0002102_abnormal_ear_morphology0.66350227
122MP0002160_abnormal_reproductive_system0.65774074
123MP0010771_integument_phenotype0.64600900
124MP0004272_abnormal_basement_membrane0.64555600
125MP0000653_abnormal_sex_gland0.63613908
126MP0002697_abnormal_eye_size0.63470440
127MP0005408_hypopigmentation0.63272870
128MP0003221_abnormal_cardiomyocyte_apopto0.63241079
129MP0010155_abnormal_intestine_physiology0.62945775
130MP0004381_abnormal_hair_follicle0.62580339
131MP0005464_abnormal_platelet_physiology0.62539686
132MP0000598_abnormal_liver_morphology0.62502319
133MP0001243_abnormal_dermal_layer0.62415362
134MP0006035_abnormal_mitochondrial_morpho0.61952445
135MP0005451_abnormal_body_composition0.61717841
136MP0000749_muscle_degeneration0.61373876
137MP0002166_altered_tumor_susceptibility0.61234165
138MP0009672_abnormal_birth_weight0.61016733
139MP0001929_abnormal_gametogenesis0.59791458
140MP0005083_abnormal_biliary_tract0.59629444
141MP0004858_abnormal_nervous_system0.58224682
142MP0002970_abnormal_white_adipose0.56558604
143MP0002075_abnormal_coat/hair_pigmentati0.55330913
144MP0003191_abnormal_cellular_cholesterol0.54970029
145MP0000003_abnormal_adipose_tissue0.52568685
146MP0005197_abnormal_uvea_morphology0.52218799

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.19355558
2Birth length less than 3rd percentile (HP:0003561)5.18900129
3Chromsome breakage (HP:0040012)4.77941791
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.73725634
5Abnormality of cells of the erythroid lineage (HP:0012130)4.34640362
6Abnormal number of erythroid precursors (HP:0012131)4.29614373
7Breast hypoplasia (HP:0003187)3.95328547
8Abnormality of chromosome stability (HP:0003220)3.52554341
9Abnormality of the preputium (HP:0100587)3.48390558
10Meckel diverticulum (HP:0002245)3.45456378
11Cholecystitis (HP:0001082)3.42529136
12Abnormal gallbladder physiology (HP:0012438)3.42529136
13Abnormality of pyrimidine metabolism (HP:0004353)3.40336342
14Oral leukoplakia (HP:0002745)3.31014058
15Abnormality of the ileum (HP:0001549)3.25936516
16Aplasia/Hypoplasia of the uvula (HP:0010293)3.19781742
17Abnormality of glycolysis (HP:0004366)3.15897842
18Macrocytic anemia (HP:0001972)3.12483989
19Patellar aplasia (HP:0006443)3.10329090
20Pallor (HP:0000980)3.09835430
21Selective tooth agenesis (HP:0001592)3.05643216
22Impulsivity (HP:0100710)3.01154114
23Rough bone trabeculation (HP:0100670)2.96271629
24Aplasia/Hypoplasia of the patella (HP:0006498)2.95448507
25Abnormal mitochondria in muscle tissue (HP:0008316)2.91436335
26Multiple enchondromatosis (HP:0005701)2.88642605
27Carpal bone hypoplasia (HP:0001498)2.79089959
28Duodenal stenosis (HP:0100867)2.76282862
29Small intestinal stenosis (HP:0012848)2.76282862
30Aplastic anemia (HP:0001915)2.75859434
31Microvesicular hepatic steatosis (HP:0001414)2.73246489
32Myelodysplasia (HP:0002863)2.70141791
33Bone marrow hypocellularity (HP:0005528)2.68983635
34Microretrognathia (HP:0000308)2.68959184
35Duplicated collecting system (HP:0000081)2.68460296
36Absent thumb (HP:0009777)2.68183779
37Progressive muscle weakness (HP:0003323)2.61917823
38Degeneration of anterior horn cells (HP:0002398)2.61714615
39Abnormality of the anterior horn cell (HP:0006802)2.61714615
40Abnormality of the heme biosynthetic pathway (HP:0010472)2.59591979
41Acute necrotizing encephalopathy (HP:0006965)2.58844155
42Increased serum pyruvate (HP:0003542)2.58066786
43Increased nuchal translucency (HP:0010880)2.54351765
44Thrombocytosis (HP:0001894)2.53083573
45Aplasia/Hypoplasia of the sacrum (HP:0008517)2.52549232
46Abnormality of reticulocytes (HP:0004312)2.52522193
47Clubbing of toes (HP:0100760)2.48406185
48Acute encephalopathy (HP:0006846)2.46504901
49Ectopic kidney (HP:0000086)2.46408037
50Absent radius (HP:0003974)2.45140827
51Proximal placement of thumb (HP:0009623)2.41997214
52Colon cancer (HP:0003003)2.39392075
53Facial cleft (HP:0002006)2.39197231
54Hypoplasia of the capital femoral epiphysis (HP:0003090)2.37394555
55Hypokinesia (HP:0002375)2.36450621
56Deviation of the thumb (HP:0009603)2.33518724
57Abnormality of the renal collecting system (HP:0004742)2.33242323
58Testicular atrophy (HP:0000029)2.30930389
59Hepatocellular necrosis (HP:0001404)2.29000293
60Premature rupture of membranes (HP:0001788)2.27803264
61Premature graying of hair (HP:0002216)2.27764591
62Absent forearm bone (HP:0003953)2.26311995
63Aplasia involving forearm bones (HP:0009822)2.26311995
64Triphalangeal thumb (HP:0001199)2.25412020
65Ragged-red muscle fibers (HP:0003200)2.24844599
66Abnormality of the duodenum (HP:0002246)2.22598430
67Trismus (HP:0000211)2.21931759
68Abnormal umbilical cord blood vessels (HP:0011403)2.20964549
69Cellular immunodeficiency (HP:0005374)2.20509596
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.19574160
71Decreased activity of mitochondrial respiratory chain (HP:0008972)2.19574160
72Increased CSF lactate (HP:0002490)2.19562541
73Abnormal trabecular bone morphology (HP:0100671)2.19536508
74Ureteral duplication (HP:0000073)2.18409021
75Tracheoesophageal fistula (HP:0002575)2.18336004
76Abnormalities of placenta or umbilical cord (HP:0001194)2.17989081
77Abnormality of the carotid arteries (HP:0005344)2.16762229
78Sloping forehead (HP:0000340)2.16173571
79Horseshoe kidney (HP:0000085)2.15329712
8011 pairs of ribs (HP:0000878)2.15051201
81Mitochondrial inheritance (HP:0001427)2.15020481
82Pancytopenia (HP:0001876)2.13563240
83Medulloblastoma (HP:0002885)2.13200089
84Poikiloderma (HP:0001029)2.12633447
85Hyperacusis (HP:0010780)2.11030046
86Nausea (HP:0002018)2.10757180
87Reduced subcutaneous adipose tissue (HP:0003758)2.10472955
88Short thumb (HP:0009778)2.10452980
89Megaloblastic anemia (HP:0001889)2.09875446
90Hepatic necrosis (HP:0002605)2.09530631
91Poor head control (HP:0002421)2.06029055
92Secondary amenorrhea (HP:0000869)2.05466814
93Petechiae (HP:0000967)2.04109123
94Neoplasm of the pancreas (HP:0002894)2.02888686
95Cerebral hypomyelination (HP:0006808)2.01757134
96Lymphoma (HP:0002665)2.00636829
97Abnormality of the umbilical cord (HP:0010881)1.99411443
98Cleft eyelid (HP:0000625)1.98945870
99Slender long bone (HP:0003100)1.98919490
100Abnormal number of incisors (HP:0011064)1.97228234
101Sparse eyelashes (HP:0000653)1.96206680
102Abnormal glycosylation (HP:0012345)1.94954666
103Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94954666
104Abnormal protein N-linked glycosylation (HP:0012347)1.94954666
105Abnormal protein glycosylation (HP:0012346)1.94954666
106Abnormality of the distal phalanges of the toes (HP:0010182)1.94730395
107Muscle fiber atrophy (HP:0100295)1.94584621
108Exercise intolerance (HP:0003546)1.93201868
109Abnormality of DNA repair (HP:0003254)1.92091715
110Leukopenia (HP:0001882)1.92043215
111IgM deficiency (HP:0002850)1.91919496
112Microglossia (HP:0000171)1.91710031
113Type I transferrin isoform profile (HP:0003642)1.91121876
114High pitched voice (HP:0001620)1.90589645
115Cerebral edema (HP:0002181)1.90007359
116Insomnia (HP:0100785)1.89596150
117Agnosia (HP:0010524)1.88352057
118Increased serum lactate (HP:0002151)1.87520782
119Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86566178
120Hypoplastic pelvis (HP:0008839)1.86065411
121Reduced antithrombin III activity (HP:0001976)1.78751276
122Progressive macrocephaly (HP:0004481)1.78477976
123Achilles tendon contracture (HP:0001771)1.77981628
124Increased intramyocellular lipid droplets (HP:0012240)1.77466271
125Abnormal lung lobation (HP:0002101)1.77351971
126Abnormal spermatogenesis (HP:0008669)1.77268345
127Vertebral compression fractures (HP:0002953)1.75204892
128Lactic acidosis (HP:0003128)1.74725485
129Premature ovarian failure (HP:0008209)1.74663054
130Atresia of the external auditory canal (HP:0000413)1.73630025
131Osteolytic defects of the phalanges of the hand (HP:0009771)1.72315868
132Osteolytic defects of the hand bones (HP:0009699)1.72315868
133Cafe-au-lait spot (HP:0000957)1.71812914
134Squamous cell carcinoma (HP:0002860)1.71741532
135Orthostatic hypotension (HP:0001278)1.71710043
136Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.71403947
137Absent epiphyses (HP:0010577)1.71403947
138Broad distal phalanx of finger (HP:0009836)1.69387340
139Generalized amyotrophy (HP:0003700)1.68628053
140Choanal atresia (HP:0000453)1.68119724
141Abnormality of T cell physiology (HP:0011840)1.65776049
142Aplasia/Hypoplasia of the thymus (HP:0010515)1.64958049
143Hypopigmented skin patches (HP:0001053)1.63948325
144Entropion (HP:0000621)1.63248767
145Exertional dyspnea (HP:0002875)1.62944707
146Nonimmune hydrops fetalis (HP:0001790)1.60188934
147Optic nerve coloboma (HP:0000588)1.59888469
148Rhabdomyosarcoma (HP:0002859)1.59659409
149Abnormality of the fetal cardiovascular system (HP:0010948)1.58350799
150Single umbilical artery (HP:0001195)1.58350799

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.63467973
2WEE14.62593066
3VRK23.91131697
4CDC73.65090776
5EIF2AK13.05261868
6NME22.77953963
7NEK22.73162647
8STK162.69373305
9SMG12.49845994
10MST1R2.46674261
11TTK2.41054086
12PLK42.38459145
13SRPK12.19266333
14VRK12.08656708
15TLK11.99902710
16PLK11.98128365
17ACVR1B1.95977089
18BRSK21.94552886
19ZAK1.92979622
20AURKB1.76924639
21NEK11.74450196
22EIF2AK31.71519072
23TESK21.68502945
24CCNB11.64756762
25CDK71.63971652
26EPHA21.63668063
27ATR1.59833667
28RPS6KA41.56855475
29MAP3K81.56477579
30MST41.53210919
31CDK41.48410386
32TSSK61.47805632
33STK41.41089173
34CHEK21.40319804
35BRSK11.39520781
36DYRK31.37108058
37MKNK11.31593550
38RPS6KB21.30877509
39IRAK31.25709305
40AURKA1.25036724
41MAP4K11.24495988
42PIM21.22531225
43PLK31.21553785
44TRIB31.21390836
45PASK1.17026636
46LIMK11.16132862
47TAF11.11565438
48IRAK41.11046895
49EIF2AK21.10892287
50ARAF1.10062675
51STK101.07733270
52KDR1.06107783
53DAPK11.03111147
54BLK1.02096786
55MAP3K101.01806772
56MET1.01304203
57TYK21.00784307
58CHEK10.96756044
59PIM10.95839095
60MKNK20.93013358
61MAP3K120.91836689
62ICK0.88034855
63BRAF0.85966849
64EEF2K0.82883756
65PDK20.78232461
66ILK0.77716306
67SIK10.76138706
68CLK10.75825215
69NEK90.74225713
70PAK40.72847699
71ABL20.72323865
72BCKDK0.69662776
73* CDK20.69097148
74PTK20.67457787
75CDK80.67321260
76ERBB40.67170914
77CSNK2A10.66478307
78SCYL20.64917780
79ATM0.64502244
80TGFBR10.64045622
81LRRK20.63885706
82RPS6KA50.61960852
83PAK10.57592331
84MAP2K30.57054689
85CSF1R0.55774886
86FLT30.55385659
87IKBKB0.54290991
88CDK60.54161832
89ERN10.54010861
90CSNK2A20.53010806
91MAP3K110.52936635
92KIT0.52155884
93BTK0.50669184
94LMTK20.50630632
95PRKCI0.49768076
96* CDK10.48949697
97PBK0.48341017
98STK30.47580312
99MAPKAPK30.47462617
100TRIM280.46725362
101LATS20.46464826
102TEC0.46032110
103CDK120.44876559
104CDK90.44468373
105SIK30.43937821
106TESK10.42726210
107JAK30.42515379
108TTN0.40506248
109CDK180.40262654
110CDK11A0.40142376
111MAPK110.39200495
112CDK150.39092759
113MYLK0.38193861
114LYN0.38059312
115NME10.37909046
116ALK0.37858918
117ZAP700.37035453
118CDK140.36775392
119MELK0.36763743
120CSNK1G30.36608127
121TAOK30.34047090
122GRK60.32653615
123TAOK20.32528262
124DAPK30.32096858
125TBK10.31669852
126CHUK0.30877577
127BMX0.28486292
128MAP3K30.27675571
129AKT20.24916306
130PKN20.24615972
131MAP2K20.23452853
132MAPKAPK20.23297095
133IKBKE0.23143635

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.63272782
2Mismatch repair_Homo sapiens_hsa034304.45397326
3Homologous recombination_Homo sapiens_hsa034403.38060838
4Ribosome_Homo sapiens_hsa030103.36266622
5Base excision repair_Homo sapiens_hsa034103.24666172
6Proteasome_Homo sapiens_hsa030503.13381072
7Nucleotide excision repair_Homo sapiens_hsa034202.89386781
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.81148582
9One carbon pool by folate_Homo sapiens_hsa006702.79188811
10RNA polymerase_Homo sapiens_hsa030202.71397965
11Spliceosome_Homo sapiens_hsa030402.67561833
12* Pyrimidine metabolism_Homo sapiens_hsa002402.57013809
13Cell cycle_Homo sapiens_hsa041102.56683275
14RNA transport_Homo sapiens_hsa030132.38019760
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.35977850
16Fanconi anemia pathway_Homo sapiens_hsa034602.32737512
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88842679
18Non-homologous end-joining_Homo sapiens_hsa034501.75914484
19p53 signaling pathway_Homo sapiens_hsa041151.60450242
20Oxidative phosphorylation_Homo sapiens_hsa001901.45390700
21Fatty acid elongation_Homo sapiens_hsa000621.41296524
22Systemic lupus erythematosus_Homo sapiens_hsa053221.36793845
23Basal transcription factors_Homo sapiens_hsa030221.35390780
24RNA degradation_Homo sapiens_hsa030181.34852413
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33905332
26Folate biosynthesis_Homo sapiens_hsa007901.30540588
27Vitamin B6 metabolism_Homo sapiens_hsa007501.27610834
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26981902
29Purine metabolism_Homo sapiens_hsa002301.26510483
30* Drug metabolism - other enzymes_Homo sapiens_hsa009831.25211753
31Pyruvate metabolism_Homo sapiens_hsa006201.22704131
32Pentose phosphate pathway_Homo sapiens_hsa000301.16788294
33mRNA surveillance pathway_Homo sapiens_hsa030150.98953063
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98673355
35Epstein-Barr virus infection_Homo sapiens_hsa051690.98446772
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97166519
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95896238
38Cysteine and methionine metabolism_Homo sapiens_hsa002700.94276308
39Herpes simplex infection_Homo sapiens_hsa051680.90226368
40Antigen processing and presentation_Homo sapiens_hsa046120.87335784
41Alzheimers disease_Homo sapiens_hsa050100.87009149
42Sulfur relay system_Homo sapiens_hsa041220.85813714
43Glutathione metabolism_Homo sapiens_hsa004800.83543869
44Selenocompound metabolism_Homo sapiens_hsa004500.83362588
45Biosynthesis of amino acids_Homo sapiens_hsa012300.81457377
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77193943
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.74124232
48Viral carcinogenesis_Homo sapiens_hsa052030.73879404
49Primary immunodeficiency_Homo sapiens_hsa053400.69663428
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67134814
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.64639494
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61089557
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60655278
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60466824
55HTLV-I infection_Homo sapiens_hsa051660.57230558
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55142180
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.54397154
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54369521
59Vibrio cholerae infection_Homo sapiens_hsa051100.53365732
60Protein export_Homo sapiens_hsa030600.52974685
61Small cell lung cancer_Homo sapiens_hsa052220.52648510
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52625811
63Fructose and mannose metabolism_Homo sapiens_hsa000510.52540881
64Carbon metabolism_Homo sapiens_hsa012000.51971339
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51541129
66Apoptosis_Homo sapiens_hsa042100.49626730
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.49494134
68Oocyte meiosis_Homo sapiens_hsa041140.48077703
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47079007
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46381367
71Legionellosis_Homo sapiens_hsa051340.45274709
72Measles_Homo sapiens_hsa051620.45211230
73Steroid biosynthesis_Homo sapiens_hsa001000.43218483
74Sulfur metabolism_Homo sapiens_hsa009200.42621623
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38562250
76N-Glycan biosynthesis_Homo sapiens_hsa005100.38116879
77* Metabolic pathways_Homo sapiens_hsa011000.37061591
78Hematopoietic cell lineage_Homo sapiens_hsa046400.36986066
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36834579
80Pancreatic cancer_Homo sapiens_hsa052120.36451783
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35973074
82Vitamin digestion and absorption_Homo sapiens_hsa049770.34382863
83Huntingtons disease_Homo sapiens_hsa050160.33594376
84Galactose metabolism_Homo sapiens_hsa000520.32788539
85Arginine and proline metabolism_Homo sapiens_hsa003300.32095785
86Phenylalanine metabolism_Homo sapiens_hsa003600.32077756
87Chronic myeloid leukemia_Homo sapiens_hsa052200.31968522
88MicroRNAs in cancer_Homo sapiens_hsa052060.31758597
89Caffeine metabolism_Homo sapiens_hsa002320.31595590
90Tyrosine metabolism_Homo sapiens_hsa003500.31422145
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30977060
92Hepatitis B_Homo sapiens_hsa051610.30938900
93Retinol metabolism_Homo sapiens_hsa008300.28708404
94Shigellosis_Homo sapiens_hsa051310.27418695
95Lysine degradation_Homo sapiens_hsa003100.26965894
96Chemical carcinogenesis_Homo sapiens_hsa052040.26574877
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26354373
98Fatty acid metabolism_Homo sapiens_hsa012120.25575788
99Arachidonic acid metabolism_Homo sapiens_hsa005900.25271318
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22913747
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.22252899
102Influenza A_Homo sapiens_hsa051640.22229973
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22204284
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22047395
105Renin-angiotensin system_Homo sapiens_hsa046140.21716534
106Alcoholism_Homo sapiens_hsa050340.21302677
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21001503
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.20725143
109Hippo signaling pathway_Homo sapiens_hsa043900.20695976
110Parkinsons disease_Homo sapiens_hsa050120.20621921
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18549212
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18141287
113beta-Alanine metabolism_Homo sapiens_hsa004100.17830661
114Regulation of autophagy_Homo sapiens_hsa041400.17799260
115Prostate cancer_Homo sapiens_hsa052150.17793356
116Adherens junction_Homo sapiens_hsa045200.17699589
117Non-small cell lung cancer_Homo sapiens_hsa052230.17322795
118Viral myocarditis_Homo sapiens_hsa054160.16338068
119Bladder cancer_Homo sapiens_hsa052190.15270010
120Melanoma_Homo sapiens_hsa052180.15065049
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14446189
122Propanoate metabolism_Homo sapiens_hsa006400.13688872
123Arginine biosynthesis_Homo sapiens_hsa002200.13645386
124Other glycan degradation_Homo sapiens_hsa005110.13292664
125Thyroid cancer_Homo sapiens_hsa052160.12662769
126Leishmaniasis_Homo sapiens_hsa051400.11305842
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09958277
128Basal cell carcinoma_Homo sapiens_hsa052170.06638664

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