TK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of protein oligomerization (GO:0032460)8.59500575
2sterol catabolic process (GO:0016127)6.28807981
3cholesterol catabolic process (GO:0006707)6.28807981
4positive regulation of protein sumoylation (GO:0033235)6.17201146
5neuron remodeling (GO:0016322)5.87682233
6regulation of protein homooligomerization (GO:0032462)5.80962098
7regulation of axon regeneration (GO:0048679)5.51795518
8regulation of neuron projection regeneration (GO:0070570)5.51795518
9snRNA processing (GO:0016180)5.49595956
10negative regulation of dendrite development (GO:2000171)5.38702916
11positive regulation of T cell chemotaxis (GO:0010820)5.37937316
12regulation of T cell chemotaxis (GO:0010819)5.37937316
13snRNA metabolic process (GO:0016073)5.14032963
14positive regulation of protein deacetylation (GO:0090312)4.47879753
15striatum development (GO:0021756)4.33858475
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.32547071
17positive regulation of gamma-delta T cell activation (GO:0046645)4.25623579
18regulation of collateral sprouting (GO:0048670)4.25432550
19macroautophagy (GO:0016236)4.11090822
20regulation of protein sumoylation (GO:0033233)4.01300817
21positive regulation of B cell differentiation (GO:0045579)3.97837216
22regulation of gamma-delta T cell differentiation (GO:0045586)3.90936765
23regulation of interleukin-12 biosynthetic process (GO:0045075)3.88104747
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.81505424
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.81505424
26antigen processing and presentation via MHC class Ib (GO:0002475)3.70408053
27negative regulation of erythrocyte differentiation (GO:0045647)3.68651149
28glandular epithelial cell development (GO:0002068)3.64189142
29regulation of protein oligomerization (GO:0032459)3.61198993
30barbed-end actin filament capping (GO:0051016)3.54412654
31regulation of regulatory T cell differentiation (GO:0045589)3.48597766
32steroid catabolic process (GO:0006706)3.47652899
33phagocytosis, engulfment (GO:0006911)3.43556041
34regulation of gamma-delta T cell activation (GO:0046643)3.39182892
35response to interleukin-15 (GO:0070672)3.38138640
36antigen processing and presentation of endogenous antigen (GO:0019883)3.36967948
37response to oxygen radical (GO:0000305)3.36867594
38alpha-linolenic acid metabolic process (GO:0036109)3.36190803
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.35606675
40cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.34307444
41erythrocyte maturation (GO:0043249)3.29178368
42retinoic acid receptor signaling pathway (GO:0048384)3.24074906
43interferon-gamma production (GO:0032609)3.23059440
44nerve growth factor signaling pathway (GO:0038180)3.22622094
45regulation of lymphocyte chemotaxis (GO:1901623)3.22066542
46pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.17797475
47UMP metabolic process (GO:0046049)3.17797475
48pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.17797475
49UMP biosynthetic process (GO:0006222)3.17797475
50keratan sulfate catabolic process (GO:0042340)3.13506714
51regulation of timing of cell differentiation (GO:0048505)3.13102761
52T cell homeostasis (GO:0043029)3.12959758
53hematopoietic stem cell differentiation (GO:0060218)3.11780149
54regulation of mitochondrial fission (GO:0090140)3.07549138
55positive regulation of histone deacetylation (GO:0031065)3.05323546
56positive regulation of NF-kappaB import into nucleus (GO:0042346)3.04591368
57production of molecular mediator involved in inflammatory response (GO:0002532)3.02699780
58cellular response to interleukin-15 (GO:0071350)3.02028227
59B cell receptor signaling pathway (GO:0050853)3.01984091
60positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.97546387
61regulation of B cell differentiation (GO:0045577)2.93637396
62negative regulation of interleukin-17 production (GO:0032700)2.93328467
63quinone biosynthetic process (GO:1901663)2.93320641
64ubiquinone biosynthetic process (GO:0006744)2.93320641
65negative regulation of protein autophosphorylation (GO:0031953)2.92351062
66positive regulation of cellular amide metabolic process (GO:0034250)2.91014022
67negative regulation of axon extension (GO:0030517)2.84864878
68negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.82217925
69negative regulation of translation, ncRNA-mediated (GO:0040033)2.82217925
70regulation of translation, ncRNA-mediated (GO:0045974)2.82217925
71megakaryocyte development (GO:0035855)2.81791747
72negative regulation of chondrocyte differentiation (GO:0032331)2.78217752
73regulation of cholesterol biosynthetic process (GO:0045540)2.76218933
74low-density lipoprotein particle clearance (GO:0034383)2.74487018
75gene silencing by RNA (GO:0031047)2.72958091
76regulation of erythrocyte differentiation (GO:0045646)2.72509800
77cellular response to ethanol (GO:0071361)2.71398878
78detection of other organism (GO:0098543)2.70139052
79rRNA methylation (GO:0031167)2.64824713
80negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.64149875
81negative regulation of cell killing (GO:0031342)2.64149875
82purine nucleotide salvage (GO:0032261)2.64147948
83definitive hemopoiesis (GO:0060216)2.63400488
84regulation of interferon-beta biosynthetic process (GO:0045357)2.63034543
85endosome to melanosome transport (GO:0035646)2.62430304
86endosome to pigment granule transport (GO:0043485)2.62430304
87oxaloacetate metabolic process (GO:0006107)2.62031886
88positive regulation of transcription factor import into nucleus (GO:0042993)2.61532295
89positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.61045654
90phosphatidylinositol dephosphorylation (GO:0046856)2.58334955
91lymphocyte homeostasis (GO:0002260)2.57703600
92regulation of development, heterochronic (GO:0040034)2.57037734
93membrane invagination (GO:0010324)2.56991998
94G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.56377432
95phospholipid dephosphorylation (GO:0046839)2.55304603
96heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.54162091
97positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.53981977
98pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.52552462
99regulation of extracellular matrix disassembly (GO:0010715)2.52514863
100complement activation, alternative pathway (GO:0006957)2.52375256
101negative regulation of complement activation (GO:0045916)2.51122504
102detection of molecule of bacterial origin (GO:0032490)2.50569701
103ubiquinone metabolic process (GO:0006743)2.50322252
104valine metabolic process (GO:0006573)2.48563757
105fibril organization (GO:0097435)2.48262874
106cellular response to epinephrine stimulus (GO:0071872)2.48118361
107response to caffeine (GO:0031000)2.46860364
108positive regulation of protein homodimerization activity (GO:0090073)2.45929312
109mitochondrial genome maintenance (GO:0000002)2.44536081
110germinal center formation (GO:0002467)2.42332271
111extracellular fibril organization (GO:0043206)2.41254801
112chondroitin sulfate catabolic process (GO:0030207)2.41138855
113apoptotic cell clearance (GO:0043277)2.38919409
114negative regulation of protein activation cascade (GO:2000258)2.38818500
115positive regulation of macrophage cytokine production (GO:0060907)2.33392540
116regulation of macrophage cytokine production (GO:0010935)2.29230103
117lipid storage (GO:0019915)2.28450883
118triglyceride catabolic process (GO:0019433)2.27945955
119positive regulation of cholesterol transport (GO:0032376)2.24453134
120positive regulation of sterol transport (GO:0032373)2.24453134
121import into cell (GO:0098657)2.23101439
122positive regulation of cholesterol efflux (GO:0010875)2.20512259
123negative regulation of humoral immune response (GO:0002921)2.18573304
124iron ion import (GO:0097286)2.17631897
125positive regulation of receptor recycling (GO:0001921)2.17539730
126regulation of type B pancreatic cell apoptotic process (GO:2000674)2.16734304
127regulation of amyloid precursor protein catabolic process (GO:1902991)2.15158800
128neutral lipid catabolic process (GO:0046461)2.11504912
129acylglycerol catabolic process (GO:0046464)2.11504912
130negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.09810881
131regulation of cholesterol storage (GO:0010885)2.09416960
132detection of external biotic stimulus (GO:0098581)2.08864184
133regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.06623074
134negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.05797396
135regulation of sequestering of triglyceride (GO:0010889)2.05694268
136regulation of beta-amyloid formation (GO:1902003)2.05471216
137macrophage activation involved in immune response (GO:0002281)2.04721383
138positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.04396508
139positive regulation of glycolytic process (GO:0045821)2.03033795
140peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.02803148
141induction of positive chemotaxis (GO:0050930)2.01492617
142type B pancreatic cell proliferation (GO:0044342)2.01053798
143response to dietary excess (GO:0002021)2.00368759
144positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.00286995
145response to epinephrine (GO:0071871)1.98368979
146regulation of complement activation (GO:0030449)1.98228660
147negative regulation of smooth muscle cell migration (GO:0014912)1.98003222
148ethanol oxidation (GO:0006069)1.97054316
149negative regulation of type 2 immune response (GO:0002829)1.96130245
150hypotonic response (GO:0006971)1.96099934
151regulation of platelet aggregation (GO:0090330)1.95338586
152positive regulation of triglyceride lipase activity (GO:0061365)1.94575371
153positive regulation of lipoprotein lipase activity (GO:0051006)1.94575371
154cortical actin cytoskeleton organization (GO:0030866)1.93232933
155stress fiber assembly (GO:0043149)1.92762776
156regulation of protein activation cascade (GO:2000257)1.92557830
157amino sugar catabolic process (GO:0046348)1.92233099
158regulation of cholesterol esterification (GO:0010872)1.91895430
159adhesion of symbiont to host cell (GO:0044650)1.90243970
160virion attachment to host cell (GO:0019062)1.90243970
161regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)1.88911323
162toxin transport (GO:1901998)1.87658842
163neutrophil activation involved in immune response (GO:0002283)1.87351848
164positive regulation of fibroblast migration (GO:0010763)1.86644488
165cellular response to vitamin (GO:0071295)1.86416647
166protein localization to endosome (GO:0036010)1.86184368
167regulation of myeloid leukocyte mediated immunity (GO:0002886)1.85890164
168transcytosis (GO:0045056)1.85684643
169positive regulation of extracellular matrix organization (GO:1903055)1.85172361
170regulation of calcineurin-NFAT signaling cascade (GO:0070884)1.84480290
171regulation of phospholipase A2 activity (GO:0032429)1.83237523
172positive regulation of membrane protein ectodomain proteolysis (GO:0051044)1.82916372
173cellular extravasation (GO:0045123)1.81398743
174cellular response to zinc ion (GO:0071294)1.81361536
175cortical cytoskeleton organization (GO:0030865)1.80648713
176plasma lipoprotein particle clearance (GO:0034381)1.80308136
177regulation of ARF protein signal transduction (GO:0032012)1.79979517
178regulation of T-helper 2 cell differentiation (GO:0045628)1.79237666
179regulation of plasminogen activation (GO:0010755)1.79234542
180positive regulation of myeloid leukocyte mediated immunity (GO:0002888)1.79156284
181cellular response to cadmium ion (GO:0071276)1.78973152
182regulation of membrane protein ectodomain proteolysis (GO:0051043)1.78633131
183positive regulation of synaptic transmission, dopaminergic (GO:0032226)1.78588616
184positive regulation of phagocytosis (GO:0050766)1.78579581
185macrophage activation (GO:0042116)1.78504673
186regulation of macrophage derived foam cell differentiation (GO:0010743)1.78419205
187fatty acid homeostasis (GO:0055089)1.78246892
188xenobiotic catabolic process (GO:0042178)1.78144296
189protein carboxylation (GO:0018214)1.77897188
190peptidyl-glutamic acid carboxylation (GO:0017187)1.77897188

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.72668010
2MYC_22102868_ChIP-Seq_BL_Human4.08793736
3SCL_19346495_ChIP-Seq_HPC-7_Human4.03953512
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.54287163
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.46643098
6GATA1_22025678_ChIP-Seq_K562_Human3.34184060
7RUNX_20019798_ChIP-Seq_JUKART_Human3.24892232
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.93341524
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.78496024
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.70767343
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.64942361
12ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.47477955
13* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.40645766
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.33060692
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.28485463
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.22414340
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.21962591
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.21139849
19GATA2_21666600_ChIP-Seq_HMVEC_Human2.18954036
20TCF7_22412390_ChIP-Seq_EML_Mouse2.15928429
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.14995191
22* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.11863573
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.10404059
24RXR_22158963_ChIP-Seq_LIVER_Mouse2.07655991
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.04841607
26KDM2B_26808549_Chip-Seq_DND41_Human2.00326116
27MAF_26560356_Chip-Seq_TH1_Human1.99654161
28PPARA_22158963_ChIP-Seq_LIVER_Mouse1.92632729
29* UTX_26944678_Chip-Seq_JUKART_Human1.92072798
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.91934870
31VDR_21846776_ChIP-Seq_THP-1_Human1.90052505
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.89905166
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88839493
34* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.87804827
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.87046799
36CIITA_25753668_ChIP-Seq_RAJI_Human1.85504648
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.83445780
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83207357
39* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82971679
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.81047606
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.78195104
42SPI1_23547873_ChIP-Seq_NB4_Human1.77595492
43* GATA1_19941827_ChIP-Seq_MEL_Mouse1.73311980
44LXR_22158963_ChIP-Seq_LIVER_Mouse1.73140104
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.73064352
46FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.70675068
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.68307989
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.67092557
49SPI1_23127762_ChIP-Seq_K562_Human1.65726224
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65024895
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.63944876
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63511239
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63292571
54KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.60679573
55KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.60679573
56KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.60679573
57FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.58905584
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.58733418
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53570739
60PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52372561
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51872473
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.50833176
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49429396
64* IRF8_27001747_Chip-Seq_BMDM_Mouse1.48951407
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47289062
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44102380
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.41617695
68VDR_24763502_ChIP-Seq_THP-1_Human1.41559680
69STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.41448239
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.41055294
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.40713059
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.40097646
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37975553
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.37721838
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35508988
76VDR_24787735_ChIP-Seq_THP-1_Human1.34993150
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34275622
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34253525
79LXR_22292898_ChIP-Seq_THP-1_Human1.34198624
80* CJUN_26792858_Chip-Seq_BT549_Human1.32378804
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30984792
82* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30430054
83GATA3_27048872_Chip-Seq_THYMUS_Human1.29093287
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28409093
85NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24141096
86MYB_26560356_Chip-Seq_TH2_Human1.23400267
87STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23287157
88EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21964527
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21145110
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20986930
91TBX20_22080862_ChIP-Seq_HEART_Mouse1.18355739
92TBX20_22328084_ChIP-Seq_HEART_Mouse1.18355739
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17645164
94JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16456743
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14938651
96MYB_26560356_Chip-Seq_TH1_Human1.14150239
97JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13890370
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13668018
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13232012
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13129972
101PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12769960
102KDM2B_26808549_Chip-Seq_JURKAT_Human1.12743727
103ZNF263_19887448_ChIP-Seq_K562_Human1.12390968
104MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12210168
105SOX2_20726797_ChIP-Seq_SW620_Human1.10974874
106NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10192696
107* NCOR1_26117541_ChIP-Seq_K562_Human1.08617360
108SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07216297
109SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06537874
110CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06349069
111TET1_21451524_ChIP-Seq_MESCs_Mouse1.05728004
112CTCF_21964334_ChIP-Seq_BJAB-B_Human1.05305847
113* MAF_26560356_Chip-Seq_TH2_Human1.04770667
114SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.04570381
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04345712
116NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03013844
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03013844
118TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02150494
119CLOCK_20551151_ChIP-Seq_293T_Human1.01587209
120* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01458656
121PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01281867
122PU_27001747_Chip-Seq_BMDM_Mouse1.00883198
123* FOXA2_19822575_ChIP-Seq_HepG2_Human1.00737578
124* BCL6_27268052_Chip-Seq_Bcells_Human0.99968656
125SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99925687
126DROSHA_22980978_ChIP-Seq_HELA_Human0.99719459
127BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99470379
128EP300_21415370_ChIP-Seq_HL-1_Mouse0.99277631
129SMC4_20622854_ChIP-Seq_HELA_Human0.99092054
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98558825
131* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98468157
132* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98280650
133SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97993706
134NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96689925
135SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95311072
136RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94390627
137SA1_27219007_Chip-Seq_Bcells_Human0.94365542
138ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94158214
139P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92244211
140SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90799206
141GBX2_23144817_ChIP-Seq_PC3_Human0.89771869
142KDM2B_26808549_Chip-Seq_K562_Human0.89309863
143ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87622510
144* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87080825
145PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86625729
146PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86497307
147CTCF_21964334_Chip-Seq_Bcells_Human0.86069992
148SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.85736960
149SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85450478
150WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85157955
151SMC1_22415368_ChIP-Seq_MEFs_Mouse0.84536848
152ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.82951068
153* BRD4_25478319_ChIP-Seq_HGPS_Human0.82731732
154CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80069208
155AHR_22903824_ChIP-Seq_MCF-7_Human0.79764728
156ESR1_21235772_ChIP-Seq_MCF-7_Human0.79206529
157PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78599126
158NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.76689975
159GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75758501

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005248_abnormal_Harderian_gland4.20682172
2MP0005671_abnormal_response_to3.70087297
3MP0003787_abnormal_imprinting3.53276210
4MP0008438_abnormal_cutaneous_collagen3.50461845
5MP0010030_abnormal_orbit_morphology3.34376259
6MP0003724_increased_susceptibility_to3.32767017
7MP0002139_abnormal_hepatobiliary_system2.88420011
8MP0002132_abnormal_respiratory_system2.86723714
9MP0001835_abnormal_antigen_presentation2.63992404
10MP0001958_emphysema2.58226968
11MP0000685_abnormal_immune_system2.51784399
12MP0009840_abnormal_foam_cell2.26381001
13MP0000465_gastrointestinal_hemorrhage2.24327281
14MP0003279_aneurysm2.22411856
15MP0003656_abnormal_erythrocyte_physiolo2.21046107
16MP0005464_abnormal_platelet_physiology2.11908800
17MP0002254_reproductive_system_inflammat2.05937327
18MP0003690_abnormal_glial_cell2.02606426
19MP0004130_abnormal_muscle_cell2.00929191
20MP0009333_abnormal_splenocyte_physiolog1.94277442
21MP0005670_abnormal_white_adipose1.93047012
22MP0009780_abnormal_chondrocyte_physiolo1.84790644
23MP0002909_abnormal_adrenal_gland1.83918255
24MP0001800_abnormal_humoral_immune1.83088522
25MP0005503_abnormal_tendon_morphology1.81933648
26MP0010234_abnormal_vibrissa_follicle1.79936532
27MP0001542_abnormal_bone_strength1.77564469
28MP0002876_abnormal_thyroid_physiology1.77125663
29MP0000343_altered_response_to1.73596249
30MP0003763_abnormal_thymus_physiology1.71180093
31MP0003436_decreased_susceptibility_to1.71078644
32MP0005360_urolithiasis1.68381154
33MP0004859_abnormal_synaptic_plasticity1.67150981
34MP0002398_abnormal_bone_marrow1.66166560
35MP0005000_abnormal_immune_tolerance1.64499947
36MP0005365_abnormal_bile_salt1.63456867
37MP0009278_abnormal_bone_marrow1.62468914
38MP0005275_abnormal_skin_tensile1.61064869
39MP0005387_immune_system_phenotype1.59748965
40MP0001790_abnormal_immune_system1.59748965
41MP0002420_abnormal_adaptive_immunity1.59364874
42MP0006054_spinal_hemorrhage1.59319297
43MP0002452_abnormal_antigen_presenting1.58997087
44* MP0002971_abnormal_brown_adipose1.57939932
45MP0001819_abnormal_immune_cell1.57805952
46MP0003252_abnormal_bile_duct1.57100530
47MP0006082_CNS_inflammation1.54902858
48MP0002723_abnormal_immune_serum1.53421980
49MP0010368_abnormal_lymphatic_system1.51554179
50MP0005164_abnormal_response_to1.50099913
51MP0000716_abnormal_immune_system1.48603488
52MP0003303_peritoneal_inflammation1.47326424
53MP0003075_altered_response_to1.46513710
54MP0002396_abnormal_hematopoietic_system1.44496012
55MP0003172_abnormal_lysosome_physiology1.41480504
56MP0002295_abnormal_pulmonary_circulatio1.40669658
57MP0008875_abnormal_xenobiotic_pharmacok1.39242117
58MP0005085_abnormal_gallbladder_physiolo1.39058860
59MP0000689_abnormal_spleen_morphology1.37825118
60MP0003633_abnormal_nervous_system1.37760808
61MP0002736_abnormal_nociception_after1.37720713
62MP0002722_abnormal_immune_system1.36987938
63MP0000003_abnormal_adipose_tissue1.36054654
64MP0005025_abnormal_response_to1.33902292
65MP0005058_abnormal_lysosome_morphology1.33004507
66MP0009785_altered_susceptibility_to1.31577406
67MP0004147_increased_porphyrin_level1.31422237
68MP0003705_abnormal_hypodermis_morpholog1.31167713
69MP0010329_abnormal_lipoprotein_level1.30917773
70MP0002429_abnormal_blood_cell1.29023727
71MP0002419_abnormal_innate_immunity1.28857178
72MP0003329_amyloid_beta_deposits1.28214342
73MP0000604_amyloidosis1.27304618
74MP0002998_abnormal_bone_remodeling1.25557940
75MP0003300_gastrointestinal_ulcer1.22376369
76MP0003879_abnormal_hair_cell1.20279070
77MP0005375_adipose_tissue_phenotype1.19174700
78MP0002249_abnormal_larynx_morphology1.18880578
79MP0001845_abnormal_inflammatory_respons1.16437028
80MP0005165_increased_susceptibility_to1.16247006
81MP0000681_abnormal_thyroid_gland1.15916874
82MP0003011_delayed_dark_adaptation1.14932079
83MP0000920_abnormal_myelination1.14315425
84MP0003091_abnormal_cell_migration1.14099599
85MP0005023_abnormal_wound_healing1.14016404
86MP0004019_abnormal_vitamin_homeostasis1.14001265
87MP0003183_abnormal_peptide_metabolism1.13611328
88MP0000767_abnormal_smooth_muscle1.12109012
89MP0008469_abnormal_protein_level1.11559346
90MP0001968_abnormal_touch/_nociception1.10393405
91MP0008260_abnormal_autophagy1.10269137
92MP0005595_abnormal_vascular_smooth1.09723112
93MP0004272_abnormal_basement_membrane1.09660450
94MP0000613_abnormal_salivary_gland1.08992585
95MP0002933_joint_inflammation1.07760803
96MP0002138_abnormal_hepatobiliary_system1.05826203
97MP0004808_abnormal_hematopoietic_stem1.04690687
98MP0003828_pulmonary_edema1.03621554
99MP0008877_abnormal_DNA_methylation1.03444971
100MP0005390_skeleton_phenotype1.01730416
101MP0005666_abnormal_adipose_tissue1.00108022
102MP0002148_abnormal_hypersensitivity_rea0.99624318
103MP0000703_abnormal_thymus_morphology0.98952895
104MP0002118_abnormal_lipid_homeostasis0.98633012
105MP0005646_abnormal_pituitary_gland0.98430674
106MP0003806_abnormal_nucleotide_metabolis0.98328348
107MP0000858_altered_metastatic_potential0.98138997
108MP0004510_myositis0.98084679
109MP0001501_abnormal_sleep_pattern0.97934626
110MP0002896_abnormal_bone_mineralization0.97313831
111MP0009764_decreased_sensitivity_to0.97127271
112MP0003045_fibrosis0.96639576
113MP0005075_abnormal_melanosome_morpholog0.95986111
114MP0001661_extended_life_span0.95946792
115MP0003567_abnormal_fetal_cardiomyocyte0.95239632
116MP0001756_abnormal_urination0.95092332
117MP0000249_abnormal_blood_vessel0.94928661
118MP0002405_respiratory_system_inflammati0.94802779
119MP0003566_abnormal_cell_adhesion0.93276945
120MP0009115_abnormal_fat_cell0.92689698
121MP0000609_abnormal_liver_physiology0.92278562
122MP0004883_abnormal_blood_vessel0.91989434
123* MP0005535_abnormal_body_temperature0.90917052
124MP0005332_abnormal_amino_acid0.90192753
125MP0000598_abnormal_liver_morphology0.89728840
126MP0000013_abnormal_adipose_tissue0.88674466
127MP0003635_abnormal_synaptic_transmissio0.88643281
128MP0000751_myopathy0.87599787
129MP0005167_abnormal_blood-brain_barrier0.87239678
130MP0003191_abnormal_cellular_cholesterol0.86380390
131MP0003866_abnormal_defecation0.86301049
132MP0000534_abnormal_ureter_morphology0.84713564
133MP0010155_abnormal_intestine_physiology0.84510590
134MP0002928_abnormal_bile_duct0.84495411
135MP0001533_abnormal_skeleton_physiology0.84304020
136MP0005319_abnormal_enzyme/_coenzyme0.83380896
137MP0010386_abnormal_urinary_bladder0.83239581
138MP0005645_abnormal_hypothalamus_physiol0.82386778
139MP0005257_abnormal_intraocular_pressure0.81586186
140MP0003195_calcinosis0.81197388
141MP0003795_abnormal_bone_structure0.81084834
142MP0001545_abnormal_hematopoietic_system0.80444160
143MP0005397_hematopoietic_system_phenotyp0.80444160
144MP0001944_abnormal_pancreas_morphology0.80311041
145MP0003959_abnormal_lean_body0.79391317
146MP0002133_abnormal_respiratory_system0.79169997
147MP0005388_respiratory_system_phenotype0.79169997
148MP0001853_heart_inflammation0.78728784
149MP0002078_abnormal_glucose_homeostasis0.77298493
150* MP0003631_nervous_system_phenotype0.77205038
151MP0005508_abnormal_skeleton_morphology0.76637308
152MP0008874_decreased_physiological_sensi0.76464081
153MP0005584_abnormal_enzyme/coenzyme_acti0.76284863
154MP0005334_abnormal_fat_pad0.76281535
155MP0005166_decreased_susceptibility_to0.74050146
156MP0002090_abnormal_vision0.73971698

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)9.21353269
2Annular pancreas (HP:0001734)6.17948423
3Failure to thrive in infancy (HP:0001531)5.23699207
4Hypochromic microcytic anemia (HP:0004840)5.15925873
5Abnormal pancreas size (HP:0012094)4.85642811
6Abnormality of glycolipid metabolism (HP:0010969)4.43885904
7Abnormality of liposaccharide metabolism (HP:0010968)4.43885904
8Abnormality of glycosphingolipid metabolism (HP:0004343)4.43885904
9Weak cry (HP:0001612)3.92647237
10Protrusio acetabuli (HP:0003179)3.72747691
11Amyloidosis (HP:0011034)3.58490202
12Absent frontal sinuses (HP:0002688)3.55474594
13Stereotypic behavior (HP:0000733)3.51610212
14Aplastic anemia (HP:0001915)3.35861572
15Vascular tortuosity (HP:0004948)3.31132102
16Vertebral compression fractures (HP:0002953)3.22351212
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.20381793
18Increased cerebral lipofuscin (HP:0011813)3.19031135
19Obsessive-compulsive behavior (HP:0000722)3.14608166
20Mitral stenosis (HP:0001718)3.13665582
21Abnormal hemoglobin (HP:0011902)3.12843533
22IgM deficiency (HP:0002850)3.12670497
23Arterial tortuosity (HP:0005116)3.08742712
24Pallor (HP:0000980)3.06289654
25Small hand (HP:0200055)3.04884914
26Open mouth (HP:0000194)3.02046142
27Premature rupture of membranes (HP:0001788)3.00544523
28Febrile seizures (HP:0002373)2.98097586
29Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.95228618
30Vacuolated lymphocytes (HP:0001922)2.79453328
31Aortic aneurysm (HP:0004942)2.78140798
32Myositis (HP:0100614)2.77341958
33Neurofibrillary tangles (HP:0002185)2.75157595
34Volvulus (HP:0002580)2.72721603
35Limb hypertonia (HP:0002509)2.71531748
36Cervical subluxation (HP:0003308)2.69025785
37Hypochromic anemia (HP:0001931)2.65314652
38Joint stiffness (HP:0001387)2.60968598
39Protruding tongue (HP:0010808)2.60584458
40Multiple enchondromatosis (HP:0005701)2.59793570
41Complement deficiency (HP:0004431)2.59762709
42Abnormality of the frontal sinuses (HP:0002687)2.57433896
43Prolonged bleeding time (HP:0003010)2.57208935
44Hypercholesterolemia (HP:0003124)2.56239743
45Abnormality of aromatic amino acid family metabolism (HP:0004338)2.55704132
46Recurrent bronchitis (HP:0002837)2.55042633
47Tented upper lip vermilion (HP:0010804)2.54191296
48Hyperacusis (HP:0010780)2.52345798
49Inflammation of the large intestine (HP:0002037)2.52290863
50Aortic dissection (HP:0002647)2.51014150
51Glomerulonephritis (HP:0000099)2.49986222
52Cerebral aneurysm (HP:0004944)2.49664075
53Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.47505932
54Microcytic anemia (HP:0001935)2.44449738
55Increased CSF protein (HP:0002922)2.44099587
56Asymmetric septal hypertrophy (HP:0001670)2.43335943
57Deep venous thrombosis (HP:0002625)2.41549394
58Gastrointestinal inflammation (HP:0004386)2.40558790
59Bicornuate uterus (HP:0000813)2.38018522
60Nuclear cataract (HP:0100018)2.37779333
61Hypoplasia of the thymus (HP:0000778)2.36932015
62Peritonitis (HP:0002586)2.36453128
63Encephalitis (HP:0002383)2.34687238
64Chronic otitis media (HP:0000389)2.32958783
65Cellulitis (HP:0100658)2.29805143
66Myocardial infarction (HP:0001658)2.29366173
67J-shaped sella turcica (HP:0002680)2.28850937
68Colitis (HP:0002583)2.28535036
69Xanthomatosis (HP:0000991)2.27625852
70Spontaneous hematomas (HP:0007420)2.27543540
71Axonal loss (HP:0003447)2.27287511
72Increased variability in muscle fiber diameter (HP:0003557)2.27200763
73Eczematoid dermatitis (HP:0000976)2.26423800
74Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.23612791
75Loss of speech (HP:0002371)2.22289045
76Abnormality of macrophages (HP:0004311)2.21809640
77Periodontitis (HP:0000704)2.21553750
78Dilatation of the ascending aorta (HP:0005111)2.19621063
79Orchitis (HP:0100796)2.19497204
80Retrobulbar optic neuritis (HP:0100654)2.19489509
81Optic neuritis (HP:0100653)2.19489509
82Chronic diarrhea (HP:0002028)2.19043054
83Supranuclear gaze palsy (HP:0000605)2.17882372
84Epistaxis (HP:0000421)2.16054072
85Cardiovascular calcification (HP:0011915)2.15963226
86Hematochezia (HP:0002573)2.14137311
87Skin nodule (HP:0200036)2.09198490
88Recurrent fungal infections (HP:0002841)2.08513113
89Wormian bones (HP:0002645)2.07770398
90Hypertriglyceridemia (HP:0002155)2.06980962
91Systemic lupus erythematosus (HP:0002725)2.06468812
92Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.06387200
93Cerebral inclusion bodies (HP:0100314)2.05681235
94Striae distensae (HP:0001065)2.05065590
95Interstitial pulmonary disease (HP:0006530)2.04661075
96Recurrent sinusitis (HP:0011108)2.04555963
97Bone cyst (HP:0012062)2.02237108
98Ovoid vertebral bodies (HP:0003300)2.01539968
99Recurrent viral infections (HP:0004429)2.00540166
100* Progressive inability to walk (HP:0002505)2.00221761
101Aneurysm (HP:0002617)1.99604545
102Recurrent abscess formation (HP:0002722)1.98240999
103Menorrhagia (HP:0000132)1.96774467
104Urinary glycosaminoglycan excretion (HP:0003541)1.96601226
105Mucopolysacchariduria (HP:0008155)1.96601226
106Osteomalacia (HP:0002749)1.94039227
107Progressive neurologic deterioration (HP:0002344)1.93968754
108Sensorimotor neuropathy (HP:0007141)1.93807021
109Gingival bleeding (HP:0000225)1.91427877
110Short nail (HP:0001799)1.91013911
111Joint hemorrhage (HP:0005261)1.90682871
112Nephritis (HP:0000123)1.90603058
113Dysostosis multiplex (HP:0000943)1.90398648
114Pathologic fracture (HP:0002756)1.88911035
115Insulin-resistant diabetes mellitus (HP:0000831)1.88404288
116Episodic fever (HP:0001954)1.88096431
117Vascular calcification (HP:0004934)1.87721939
118Panhypogammaglobulinemia (HP:0003139)1.87579415
119Abnormal delayed hypersensitivity skin test (HP:0002963)1.86858748
120Severe global developmental delay (HP:0011344)1.86559898
121Meningitis (HP:0001287)1.83727144
122Hyperlipoproteinemia (HP:0010980)1.83698680
123Abnormality of T cell physiology (HP:0011840)1.83463605
124Recurrent gram-negative bacterial infections (HP:0005420)1.82818850
125Agammaglobulinemia (HP:0004432)1.82583900
126Abnormality of skeletal muscle fiber size (HP:0012084)1.82573269
127Joint swelling (HP:0001386)1.81250378
128Glucose intolerance (HP:0000833)1.81008917
129Papilledema (HP:0001085)1.80193687
130Osteolytic defects of the hand bones (HP:0009699)1.78664535
131Osteolytic defects of the phalanges of the hand (HP:0009771)1.78664535
132Smooth philtrum (HP:0000319)1.78639692
133Spondylolisthesis (HP:0003302)1.78223599
134Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77300269
135Abnormality of polysaccharide metabolism (HP:0011012)1.77300269
136Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77300269
137Abnormal platelet function (HP:0011869)1.77126537
138Impaired platelet aggregation (HP:0003540)1.77126537
139Broad face (HP:0000283)1.77086347
140Cheilitis (HP:0100825)1.76302959
141Chronic sinusitis (HP:0011109)1.76272475
142Abnormality of the periventricular white matter (HP:0002518)1.75543869
143Renal Fanconi syndrome (HP:0001994)1.75107758
144Gingivitis (HP:0000230)1.74207574
145Abnormality of the nasal mucosa (HP:0000433)1.74122502
146Aortic regurgitation (HP:0001659)1.73486430
147Elevated erythrocyte sedimentation rate (HP:0003565)1.73402587
148Bruising susceptibility (HP:0000978)1.73040968
149Abnormality of calcium-phosphate metabolism (HP:0100530)1.72982377
150Conical tooth (HP:0000698)1.72912649
151Bradycardia (HP:0001662)1.72615808
152Polycythemia (HP:0001901)1.72556452
153Large eyes (HP:0001090)1.72191305
154Aortic valve stenosis (HP:0001650)1.71835953
155Follicular hyperkeratosis (HP:0007502)1.71053414
156Recurrent bacterial skin infections (HP:0005406)1.70487261
157Hypercortisolism (HP:0001578)1.70391811
158Hepatitis (HP:0012115)1.70025424
159Purpura (HP:0000979)1.68402004
160Abnormality of complement system (HP:0005339)1.68117817
161Abnormal eating behavior (HP:0100738)1.67728100
162Thin upper lip vermilion (HP:0000219)1.66221422
163Acanthosis nigricans (HP:0000956)1.65384421
164Hemorrhage of the eye (HP:0011885)1.65236404
165Hyperglycemia (HP:0003074)1.64954070
166Pulmonary artery stenosis (HP:0004415)1.64526363
167Abnormality of skull ossification (HP:0002703)1.64433990
168Prolonged neonatal jaundice (HP:0006579)1.64383868
169Insulin resistance (HP:0000855)1.62569571
170Abnormality of monocarboxylic acid metabolism (HP:0010996)1.59731247
171Scanning speech (HP:0002168)1.59389062
172Soft skin (HP:0000977)1.57861554
173Mutism (HP:0002300)1.56245964
174Action tremor (HP:0002345)1.55885008

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR34.48098279
2MAP3K123.75940608
3SIK13.35636486
4MAP4K13.11215719
5RIPK42.63650204
6FGFR42.61294488
7CAMKK22.48811790
8DYRK1A2.40776884
9FES2.20150828
10ZAP702.06284604
11EPHB12.02554924
12SYK2.02485900
13DYRK1B2.00646220
14TESK11.91870916
15FLT31.87303372
16JAK31.81552760
17JAK11.79558075
18TYK21.76504168
19PINK11.70166250
20IKBKE1.66736178
21BTK1.56434319
22SIK31.55817827
23CSF1R1.51381607
24TGFBR21.50261986
25UHMK11.46175377
26GRK61.45951182
27PKN21.39934545
28DDR21.39409243
29RIPK11.38887921
30PTK2B1.35761501
31STK381.35423068
32TXK1.33992188
33ERN11.33820017
34MAP3K141.32205688
35FER1.31642234
36BLK1.31411882
37KIT1.27738975
38MOS1.26889858
39MAP3K91.26804280
40MAPK131.26721606
41BCKDK1.25511272
42FRK1.23741647
43LIMK11.22021722
44PRKCH1.21485401
45MAP3K61.21279936
46PDK11.20398451
47CAMKK11.19663684
48MAPKAPK31.18043022
49NEK91.17731342
50TAOK31.15666630
51EEF2K1.15082800
52MAP3K101.13230308
53MAP3K71.12675697
54MAPK121.11395916
55SIK21.10182290
56SGK31.09815050
57CDK61.06060498
58TAOK11.05120075
59TRPM71.04381965
60HCK1.03725556
61PAK61.00358630
62JAK21.00295624
63GRK50.99572210
64ABL20.99179851
65HIPK20.97883426
66MAP2K60.96452889
67EPHA30.96110662
68TBK10.95219944
69CDC42BPA0.92766200
70ARAF0.91924830
71RPS6KB20.91714630
72PRPF4B0.87393899
73ITK0.85235257
74KSR20.84513377
75MARK20.84478736
76PHKG10.82770305
77PHKG20.82770305
78PDPK10.81364006
79MAPK70.80640813
80NTRK20.80099665
81PTK20.77021202
82GRK70.76939772
83LCK0.76055365
84LYN0.75514257
85PRKG20.73225401
86PDGFRA0.73176183
87BMPR20.72972629
88LMTK20.72726969
89TRIB30.72203857
90CDK190.71733910
91NTRK10.71004606
92TNIK0.69535538
93RET0.69153905
94MARK10.69075889
95CSNK1G30.67553610
96ALK0.66983219
97PAK40.66359537
98PRKAA20.66081828
99SGK2230.65618662
100SGK4940.65618662
101CSNK1G10.64262489
102GSK3A0.64068144
103DAPK10.63064487
104NME20.62888176
105PRKD10.62627154
106SGK20.62314238
107PDGFRB0.60862572
108PTK60.60852996
109CDK40.59719805
110MAPK110.59047879
111ADRBK10.58496330
112MAP2K40.58343972
113PRKD20.57531617
114MAP3K20.57229783
115MAP3K30.56098198
116ROCK20.53737454
117MAP3K110.53326843
118PAK30.53064492
119MYLK0.52903036
120MAPK150.52857442
121TEC0.51236058
122MAP2K30.50596635
123CHUK0.50373498
124CDK50.49581441
125LRRK20.48546054
126TIE10.48368414
127FGFR20.48172733
128NLK0.48147955
129ABL10.47430655
130KDR0.47375163
131RPS6KA20.47000900
132MAP2K10.46562063
133TNK20.46416924
134MAP3K130.46164203
135MAPK40.46060072
136CAMK10.45746925
137PIK3CG0.45042878
138AKT30.45023675
139CSNK1G20.43862018
140CSNK1A1L0.43818395
141PRKCQ0.42807787
142TYRO30.41384067
143MAP3K10.39721264
144MATK0.39623212
145DAPK20.39401714
146CSK0.38061553
147IKBKB0.36360465
148MAPK30.35785977
149NTRK30.35015984

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004505.32434833
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.49855475
3Non-small cell lung cancer_Homo sapiens_hsa052232.34747754
4Staphylococcus aureus infection_Homo sapiens_hsa051502.24216561
5B cell receptor signaling pathway_Homo sapiens_hsa046622.12765739
6Primary immunodeficiency_Homo sapiens_hsa053402.09562117
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.87804505
8Complement and coagulation cascades_Homo sapiens_hsa046101.83999541
9Other glycan degradation_Homo sapiens_hsa005111.75741102
10Taste transduction_Homo sapiens_hsa047421.70462305
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.63569579
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.59084961
13ABC transporters_Homo sapiens_hsa020101.58695799
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50855816
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.48542451
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.43554612
17Leishmaniasis_Homo sapiens_hsa051401.36940570
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36250013
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.31738463
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.28793884
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27469915
22Prion diseases_Homo sapiens_hsa050201.26178839
23Osteoclast differentiation_Homo sapiens_hsa043801.25595773
24Synaptic vesicle cycle_Homo sapiens_hsa047211.24240060
25Renin secretion_Homo sapiens_hsa049241.23994769
26Histidine metabolism_Homo sapiens_hsa003401.22039037
27Measles_Homo sapiens_hsa051621.19961370
28* Pyrimidine metabolism_Homo sapiens_hsa002401.18541176
29Acute myeloid leukemia_Homo sapiens_hsa052211.16889331
30Platelet activation_Homo sapiens_hsa046111.10133258
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09797439
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09040080
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08993030
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07856126
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07779676
36Arginine biosynthesis_Homo sapiens_hsa002201.06411139
37Vibrio cholerae infection_Homo sapiens_hsa051101.04913773
38Collecting duct acid secretion_Homo sapiens_hsa049661.01337527
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00389225
40Chronic myeloid leukemia_Homo sapiens_hsa052200.98870979
41Lysosome_Homo sapiens_hsa041420.97053500
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96502850
43Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95962332
44Insulin resistance_Homo sapiens_hsa049310.95700018
45Nitrogen metabolism_Homo sapiens_hsa009100.92516423
46Inositol phosphate metabolism_Homo sapiens_hsa005620.91571264
47Phagosome_Homo sapiens_hsa041450.90504913
48Glycerolipid metabolism_Homo sapiens_hsa005610.88430445
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88419506
50Chemokine signaling pathway_Homo sapiens_hsa040620.88214937
51Olfactory transduction_Homo sapiens_hsa047400.87526484
52T cell receptor signaling pathway_Homo sapiens_hsa046600.87187095
53Prolactin signaling pathway_Homo sapiens_hsa049170.84780265
54Shigellosis_Homo sapiens_hsa051310.83949472
55Rheumatoid arthritis_Homo sapiens_hsa053230.83782042
56Starch and sucrose metabolism_Homo sapiens_hsa005000.82118688
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81979491
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81030500
59ECM-receptor interaction_Homo sapiens_hsa045120.80642736
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80316101
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80166105
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79668909
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.77927753
64Focal adhesion_Homo sapiens_hsa045100.77532963
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76085681
66Fatty acid elongation_Homo sapiens_hsa000620.75864206
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75238270
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.74333039
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.74232247
70Arachidonic acid metabolism_Homo sapiens_hsa005900.72658510
71Hematopoietic cell lineage_Homo sapiens_hsa046400.72450991
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70186925
73GnRH signaling pathway_Homo sapiens_hsa049120.69867006
74Gastric acid secretion_Homo sapiens_hsa049710.68378622
75Cholinergic synapse_Homo sapiens_hsa047250.67807612
76Peroxisome_Homo sapiens_hsa041460.67547988
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67516655
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67495329
79Salivary secretion_Homo sapiens_hsa049700.67375541
80Choline metabolism in cancer_Homo sapiens_hsa052310.66857669
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.66444525
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.65770433
83Chemical carcinogenesis_Homo sapiens_hsa052040.65449602
84Fatty acid metabolism_Homo sapiens_hsa012120.64882121
85Pertussis_Homo sapiens_hsa051330.64375399
86Butanoate metabolism_Homo sapiens_hsa006500.63250461
87Salmonella infection_Homo sapiens_hsa051320.62011876
88Mineral absorption_Homo sapiens_hsa049780.61747195
89Endocytosis_Homo sapiens_hsa041440.61185466
90Insulin secretion_Homo sapiens_hsa049110.61033630
91Tyrosine metabolism_Homo sapiens_hsa003500.60737582
92Fatty acid degradation_Homo sapiens_hsa000710.59751455
93Bile secretion_Homo sapiens_hsa049760.59702030
94Type II diabetes mellitus_Homo sapiens_hsa049300.59197274
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58825162
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58630600
97Phenylalanine metabolism_Homo sapiens_hsa003600.58353547
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57825302
99Sphingolipid metabolism_Homo sapiens_hsa006000.57808993
100Tuberculosis_Homo sapiens_hsa051520.57791482
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.57533686
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57412615
103VEGF signaling pathway_Homo sapiens_hsa043700.56218016
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55753445
105Sulfur metabolism_Homo sapiens_hsa009200.55087872
106Malaria_Homo sapiens_hsa051440.54905270
107Ovarian steroidogenesis_Homo sapiens_hsa049130.54804777
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54712840
109Tryptophan metabolism_Homo sapiens_hsa003800.54622813
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.54481458
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.54333705
112Cocaine addiction_Homo sapiens_hsa050300.54265242
113Antigen processing and presentation_Homo sapiens_hsa046120.53340246
114Insulin signaling pathway_Homo sapiens_hsa049100.53094583
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.52634314
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51629973
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51578199
118Morphine addiction_Homo sapiens_hsa050320.51507705
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.50512175
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50188987
121beta-Alanine metabolism_Homo sapiens_hsa004100.49849553
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49828284
123Circadian entrainment_Homo sapiens_hsa047130.49344290
124Toxoplasmosis_Homo sapiens_hsa051450.49242195
125Thyroid hormone synthesis_Homo sapiens_hsa049180.49106391
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.48977864
127PPAR signaling pathway_Homo sapiens_hsa033200.48801348
128Long-term potentiation_Homo sapiens_hsa047200.48085669
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47820308
130Protein digestion and absorption_Homo sapiens_hsa049740.47530641
131Galactose metabolism_Homo sapiens_hsa000520.47033746
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.46673318
133GABAergic synapse_Homo sapiens_hsa047270.46466135
134Circadian rhythm_Homo sapiens_hsa047100.46391572
135Amoebiasis_Homo sapiens_hsa051460.46302967
136Dorso-ventral axis formation_Homo sapiens_hsa043200.46088372
137Glucagon signaling pathway_Homo sapiens_hsa049220.45279206
138Influenza A_Homo sapiens_hsa051640.45156263
139Legionellosis_Homo sapiens_hsa051340.45030629
140* Drug metabolism - other enzymes_Homo sapiens_hsa009830.43486977
141AMPK signaling pathway_Homo sapiens_hsa041520.43315386
142TNF signaling pathway_Homo sapiens_hsa046680.43143586
143Type I diabetes mellitus_Homo sapiens_hsa049400.40905979
144Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40537598
145Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40344250

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