TKFC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been identified, but the full-length nature of only one has been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.32327563
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.32327563
3L-phenylalanine metabolic process (GO:0006558)7.07869574
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.07869574
5aromatic amino acid family catabolic process (GO:0009074)6.65286437
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.19346291
7epoxygenase P450 pathway (GO:0019373)6.11288700
8indole-containing compound catabolic process (GO:0042436)6.07588449
9indolalkylamine catabolic process (GO:0046218)6.07588449
10tryptophan catabolic process (GO:0006569)6.07588449
11glyoxylate metabolic process (GO:0046487)5.93510855
12kynurenine metabolic process (GO:0070189)5.90038720
13tryptophan metabolic process (GO:0006568)5.71377885
14bile acid biosynthetic process (GO:0006699)5.65391283
15cysteine metabolic process (GO:0006534)5.58477017
16urea cycle (GO:0000050)5.57424353
17urea metabolic process (GO:0019627)5.57424353
18angiotensin maturation (GO:0002003)5.54713505
19alpha-linolenic acid metabolic process (GO:0036109)5.47390664
20proline metabolic process (GO:0006560)5.40388790
21regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.39717920
22high-density lipoprotein particle remodeling (GO:0034375)5.35904315
23sulfur amino acid catabolic process (GO:0000098)5.28514365
24negative regulation of fibrinolysis (GO:0051918)5.23994729
25serine family amino acid catabolic process (GO:0009071)5.16587796
26intestinal absorption (GO:0050892)5.13394795
27nitrogen cycle metabolic process (GO:0071941)5.12805944
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.06990854
29lysine metabolic process (GO:0006553)5.06488299
30lysine catabolic process (GO:0006554)5.06488299
31protein carboxylation (GO:0018214)5.00084400
32peptidyl-glutamic acid carboxylation (GO:0017187)5.00084400
33regulation of fibrinolysis (GO:0051917)4.99170030
34proline biosynthetic process (GO:0006561)4.98950585
35complement activation, alternative pathway (GO:0006957)4.96302678
36regulation of protein activation cascade (GO:2000257)4.95039803
37homocysteine metabolic process (GO:0050667)4.91844506
38bile acid metabolic process (GO:0008206)4.86673879
39NADH metabolic process (GO:0006734)4.86234261
40regulation of triglyceride catabolic process (GO:0010896)4.84352221
41aromatic amino acid family metabolic process (GO:0009072)4.83933807
42fat-soluble vitamin biosynthetic process (GO:0042362)4.83901097
43regulation of cholesterol esterification (GO:0010872)4.80174180
44reverse cholesterol transport (GO:0043691)4.75252348
45amino-acid betaine metabolic process (GO:0006577)4.73375460
46drug metabolic process (GO:0017144)4.65769038
47regulation of complement activation (GO:0030449)4.62329134
48protein-lipid complex remodeling (GO:0034368)4.60381226
49macromolecular complex remodeling (GO:0034367)4.60381226
50plasma lipoprotein particle remodeling (GO:0034369)4.60381226
51alpha-amino acid catabolic process (GO:1901606)4.57957826
52negative regulation of cholesterol transport (GO:0032375)4.57403019
53negative regulation of sterol transport (GO:0032372)4.57403019
54tyrosine metabolic process (GO:0006570)4.53757462
55acylglycerol homeostasis (GO:0055090)4.52487808
56triglyceride homeostasis (GO:0070328)4.52487808
57phospholipid efflux (GO:0033700)4.52332504
58diacylglycerol metabolic process (GO:0046339)4.46665079
59plasma lipoprotein particle organization (GO:0071827)4.46143281
60cellular ketone body metabolic process (GO:0046950)4.42729466
61drug catabolic process (GO:0042737)4.37569289
62fructose metabolic process (GO:0006000)4.33086276
63glycine metabolic process (GO:0006544)4.32441319
64serine family amino acid metabolic process (GO:0009069)4.32168180
65glutamate metabolic process (GO:0006536)4.29188579
66indolalkylamine metabolic process (GO:0006586)4.28320147
67bile acid and bile salt transport (GO:0015721)4.27796397
68cellular glucuronidation (GO:0052695)4.27773153
69cellular amino acid catabolic process (GO:0009063)4.24862601
70cellular modified amino acid catabolic process (GO:0042219)4.23089310
71plasma lipoprotein particle clearance (GO:0034381)4.20169783
72coenzyme catabolic process (GO:0009109)4.17046351
73glutamine family amino acid biosynthetic process (GO:0009084)4.15918255
74benzene-containing compound metabolic process (GO:0042537)4.14528940
75amine catabolic process (GO:0009310)4.14351831
76cellular biogenic amine catabolic process (GO:0042402)4.14351831
77protein-lipid complex subunit organization (GO:0071825)4.11040483
78drug transmembrane transport (GO:0006855)4.10017201
79cholesterol efflux (GO:0033344)4.09994952
80positive regulation of fatty acid biosynthetic process (GO:0045723)4.07809440
81regulation of cholesterol metabolic process (GO:0090181)4.07477681
82serine family amino acid biosynthetic process (GO:0009070)4.07398127
83ethanol oxidation (GO:0006069)4.03006222
84urate metabolic process (GO:0046415)4.01100588
85ethanol metabolic process (GO:0006067)4.00937257
86dicarboxylic acid biosynthetic process (GO:0043650)3.98458863
87plasma lipoprotein particle assembly (GO:0034377)3.98413582
88imidazole-containing compound metabolic process (GO:0052803)3.95784396
89positive regulation of triglyceride lipase activity (GO:0061365)3.92515391
90positive regulation of lipoprotein lipase activity (GO:0051006)3.92515391
91arginine metabolic process (GO:0006525)3.90932577
92regulation of cholesterol homeostasis (GO:2000188)3.86932301
93aldehyde catabolic process (GO:0046185)3.86574489
94glucuronate metabolic process (GO:0019585)3.83665119
95uronic acid metabolic process (GO:0006063)3.83665119
96ketone body metabolic process (GO:1902224)3.82368669
97short-chain fatty acid metabolic process (GO:0046459)3.80995595
98cholesterol homeostasis (GO:0042632)3.78612372
99regulation of bile acid biosynthetic process (GO:0070857)3.76136068
100lipoprotein transport (GO:0042953)3.76115852
101aspartate family amino acid catabolic process (GO:0009068)3.74716023
102omega-hydroxylase P450 pathway (GO:0097267)3.74709949
103exogenous drug catabolic process (GO:0042738)3.74499341
104acetyl-CoA metabolic process (GO:0006084)3.74335119
105sterol homeostasis (GO:0055092)3.74152515
106carboxylic acid catabolic process (GO:0046395)3.74129902
107organic acid catabolic process (GO:0016054)3.74129902
108fibrinolysis (GO:0042730)3.73985361
109phospholipid homeostasis (GO:0055091)3.73075709
110flavonoid metabolic process (GO:0009812)3.72631778
111low-density lipoprotein particle remodeling (GO:0034374)3.67920215
112positive regulation of lipid catabolic process (GO:0050996)3.66240174
113response to nitrosative stress (GO:0051409)3.63840859
114very-low-density lipoprotein particle assembly (GO:0034379)3.63811895
115intestinal cholesterol absorption (GO:0030299)3.61986072
116protein-lipid complex assembly (GO:0065005)3.60783583
117blood coagulation, intrinsic pathway (GO:0007597)3.60097294
118lipoprotein metabolic process (GO:0042157)3.57215381
119regulation of cholesterol biosynthetic process (GO:0045540)3.56881634
120cofactor catabolic process (GO:0051187)3.56492733
121hormone catabolic process (GO:0042447)3.55928895
1222-oxoglutarate metabolic process (GO:0006103)3.55247903
123alkaloid metabolic process (GO:0009820)3.53214237
124vitamin transmembrane transport (GO:0035461)3.43863718
125oxidative demethylation (GO:0070989)3.34025744
126regulation of plasminogen activation (GO:0010755)3.28453187
127drug transport (GO:0015893)3.26246862
128oxaloacetate metabolic process (GO:0006107)3.26143332
129positive regulation of cellular amine metabolic process (GO:0033240)3.21615785
130complement activation, classical pathway (GO:0006958)3.20913125
131vitamin biosynthetic process (GO:0009110)3.17196578
132peptide catabolic process (GO:0043171)3.16835335
133L-ascorbic acid metabolic process (GO:0019852)3.14271862
134positive regulation of triglyceride metabolic process (GO:0090208)3.13419871
135regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.12896651
136endocrine process (GO:0050886)3.12896651
137regulation of systemic arterial blood pressure by hormone (GO:0001990)3.12896651
138negative regulation of hemostasis (GO:1900047)3.08557313
139negative regulation of blood coagulation (GO:0030195)3.08557313
140primary alcohol catabolic process (GO:0034310)3.00609553
141protein activation cascade (GO:0072376)3.00281151
142renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.00233612

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.29857054
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.20909998
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.67242233
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.42126608
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.10755978
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.94106145
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.86876065
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.97765946
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.89221782
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.22047073
11VDR_21846776_ChIP-Seq_THP-1_Human2.18522522
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11550580
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.10239668
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.09872538
15P68_20966046_ChIP-Seq_HELA_Human2.02282164
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7379477
17MYC_22102868_ChIP-Seq_BL_Human1.84211203
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82695008
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.74454022
20CLOCK_20551151_ChIP-Seq_293T_Human1.65593375
21BCL6_27268052_Chip-Seq_Bcells_Human1.64047603
22FOXA2_19822575_ChIP-Seq_HepG2_Human1.63287929
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.61032667
24E2F1_20622854_ChIP-Seq_HELA_Human1.56685724
25SMC4_20622854_ChIP-Seq_HELA_Human1.56680782
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51713130
27HNF4A_19822575_ChIP-Seq_HepG2_Human1.51223188
28PHF8_20622854_ChIP-Seq_HELA_Human1.48214460
29ELF1_20517297_ChIP-Seq_JURKAT_Human1.43973311
30SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41650115
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.37076434
32SA1_27219007_Chip-Seq_ERYTHROID_Human1.34771537
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34560225
34CREB1_26743006_Chip-Seq_LNCaP_Human1.33602689
35CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27540347
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.27213030
37CTCF_27219007_Chip-Seq_Bcells_Human1.26974187
38HTT_18923047_ChIP-ChIP_STHdh_Human1.26811145
39RXRA_24833708_ChIP-Seq_LIVER_Mouse1.24492224
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24286309
41YY1_22570637_ChIP-Seq_MALME-3M_Human1.24000696
42SA1_27219007_Chip-Seq_Bcells_Human1.23561718
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21803815
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19774220
45SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19143999
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19037970
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18964417
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18029453
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17691588
50RUNX1_27514584_Chip-Seq_MCF-7_Human1.16007044
51GATA1_22025678_ChIP-Seq_K562_Human1.15782491
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15342250
53CTCF_20526341_ChIP-Seq_ESCs_Human1.15338065
54P300_27268052_Chip-Seq_Bcells_Human1.12062676
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12052850
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10432857
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10080017
58ETS1_21867929_ChIP-Seq_TH2_Mouse1.09534091
59ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09429275
60CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09256319
61PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08887000
62JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.06702801
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05996168
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04714208
65EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04321615
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.03675265
67TP53_22127205_ChIP-Seq_IMR90_Human1.03619903
68CTCF_26484167_Chip-Seq_Bcells_Mouse1.02904728
69GATA4_25053715_ChIP-Seq_YYC3_Human1.02720290
70FOXP1_21924763_ChIP-Seq_HESCs_Human1.02564634
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02291349
72CTCF_21964334_ChIP-Seq_BJAB-B_Human1.02205935
73TP63_22573176_ChIP-Seq_HFKS_Human1.02031844
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02028366
75VDR_24763502_ChIP-Seq_THP-1_Human1.01632478
76CTCF_21964334_Chip-Seq_Bcells_Human1.01600655
77HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01272536
78EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99709797
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98510106
80RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97063971
81NCOR1_26117541_ChIP-Seq_K562_Human0.96916413
82TCF7_22412390_ChIP-Seq_EML_Mouse0.96784868
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96306564
84KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94983486
85ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94440426
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88694452
87IRF8_22096565_ChIP-ChIP_GC-B_Human0.87412780
88RARA_24833708_ChIP-Seq_LIVER_Mouse0.84642149
89NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81094699
90ZNF263_19887448_ChIP-Seq_K562_Human0.80627182
91CDX2_20551321_ChIP-Seq_CACO-2_Human0.79564312
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78789390
93AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78624585
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77519706
95KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77428777
96ESR2_21235772_ChIP-Seq_MCF-7_Human0.77100495
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76386948
98LXR_22292898_ChIP-Seq_THP-1_Human0.74671574
99STAT3_1855785_ChIP-Seq_MESCs_Mouse0.72807079
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72688238
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.72062220
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.72050337
103PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.71086114
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70608361
105AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69988227
106SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69724262
107RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69195211
108RARB_24833708_ChIP-Seq_LIVER_Mouse0.69088007
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.66930712
110GATA6_25053715_ChIP-Seq_YYC3_Human0.65143900
111ESR1_21235772_ChIP-Seq_MCF-7_Human0.63185225
112CEBPB_22108803_ChIP-Seq_LS180_Human0.61801352
113BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59841521
114MYC_19915707_ChIP-ChIP_AK7_Human0.55829997
115EGR1_19032775_ChIP-ChIP_M12_Human0.55354438
116AR_20517297_ChIP-Seq_VCAP_Human0.54907829
117FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.54453772
118FOXO3_23340844_ChIP-Seq_DLD1_Human0.53974629
119PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53885150
120STAT1_17558387_ChIP-Seq_HELA_Human0.52423641
121ESET_19884257_ChIP-Seq_ESCs_Mouse0.51768285
122PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.51585797
123FOXA1_25552417_ChIP-Seq_VCAP_Human0.50520058
124PPAR_26484153_Chip-Seq_NCI-H1993_Human0.50417653
125FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49762823
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.48531701
127P53_21459846_ChIP-Seq_SAOS-2_Human0.48215116
128NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.47843154
129NRF2_20460467_ChIP-Seq_MEFs_Mouse0.47843154
130GATA2_19941826_ChIP-Seq_K562_Human0.46665917
131PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46515035
132GATA1_19941827_ChIP-Seq_MEL_Mouse0.45338297
133CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.45334142
134CBP_21632823_ChIP-Seq_H3396_Human0.45187900
135TAF2_19829295_ChIP-Seq_ESCs_Human0.45096919
136SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.44790808
137RACK7_27058665_Chip-Seq_MCF-7_Human0.44676427
138PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44541835
139SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.44213228
140BCOR_27268052_Chip-Seq_Bcells_Human0.43345164
141GATA1_19941826_ChIP-Seq_K562_Human0.41822890
142SPI1_26923725_Chip-Seq_HPCs_Mouse0.41388648
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.41252273
144TET1_21451524_ChIP-Seq_MESCs_Mouse0.41071749
145EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.40792578
146GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.40411271
147SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40195090
148SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.40151175
149MYC_27129775_Chip-Seq_CORNEA_Mouse0.39950918
150LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.39723303
151GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.39404428
152ERG_20517297_ChIP-Seq_VCAP_Human0.38281226
153P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.37957403
154STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37794105
155TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.37716504

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.17867658
2MP0005360_urolithiasis8.12382848
3MP0005085_abnormal_gallbladder_physiolo6.15406289
4MP0005365_abnormal_bile_salt5.93462451
5MP0008875_abnormal_xenobiotic_pharmacok5.02035490
6MP0003806_abnormal_nucleotide_metabolis3.99563726
7MP0003252_abnormal_bile_duct3.91826571
8MP0010329_abnormal_lipoprotein_level3.51615850
9MP0009840_abnormal_foam_cell3.32916837
10MP0005332_abnormal_amino_acid2.98631404
11MP0001666_abnormal_nutrient_absorption2.80388167
12MP0003195_calcinosis2.79598408
13MP0005083_abnormal_biliary_tract2.76527738
14MP0003183_abnormal_peptide_metabolism2.62969092
15MP0004019_abnormal_vitamin_homeostasis2.55107709
16MP0003191_abnormal_cellular_cholesterol2.31394778
17MP0000609_abnormal_liver_physiology2.10803584
18MP0002138_abnormal_hepatobiliary_system2.10051566
19MP0002118_abnormal_lipid_homeostasis2.04510237
20MP0000566_synostosis1.91367419
21MP0005319_abnormal_enzyme/_coenzyme1.83526414
22MP0003868_abnormal_feces_composition1.75261227
23MP0001764_abnormal_homeostasis1.62477449
24MP0005584_abnormal_enzyme/coenzyme_acti1.59435880
25MP0009643_abnormal_urine_homeostasis1.54975478
26MP0009379_abnormal_foot_pigmentation1.50775623
27MP0000678_abnormal_parathyroid_gland1.43420137
28MP0005451_abnormal_body_composition1.41266895
29MP0010155_abnormal_intestine_physiology1.40852853
30MP0003011_delayed_dark_adaptation1.39810868
31MP0009697_abnormal_copulation1.39040106
32MP0003172_abnormal_lysosome_physiology1.38875242
33MP0004858_abnormal_nervous_system1.27793085
34MP0003186_abnormal_redox_activity1.26939790
35MP0001873_stomach_inflammation1.26684248
36MP0002089_abnormal_postnatal_growth/wei1.25625491
37MP0004147_increased_porphyrin_level1.23828832
38MP0003705_abnormal_hypodermis_morpholog1.20356028
39MP0005636_abnormal_mineral_homeostasis1.17397276
40MP0000598_abnormal_liver_morphology1.16796960
41MP0003656_abnormal_erythrocyte_physiolo1.12461533
42MP0005409_darkened_coat_color1.07745170
43MP0001664_abnormal_digestion1.06700822
44MP0002249_abnormal_larynx_morphology1.05432744
45MP0005647_abnormal_sex_gland1.00976675
46MP0003879_abnormal_hair_cell1.00973654
47MP0009764_decreased_sensitivity_to0.99838401
48MP0000604_amyloidosis0.99251993
49MP0002132_abnormal_respiratory_system0.97821755
50MP0002254_reproductive_system_inflammat0.96325155
51MP0003866_abnormal_defecation0.93478385
52MP0009763_increased_sensitivity_to0.92284635
53MP0002098_abnormal_vibrissa_morphology0.90018789
54MP0005084_abnormal_gallbladder_morpholo0.89635703
55MP0009642_abnormal_blood_homeostasis0.89265049
56MP0005670_abnormal_white_adipose0.88797320
57MP0000490_abnormal_crypts_of0.87216550
58MP0008469_abnormal_protein_level0.87143659
59MP0006036_abnormal_mitochondrial_physio0.86256993
60MP0001756_abnormal_urination0.83985211
61MP0000477_abnormal_intestine_morphology0.80624461
62MP0002876_abnormal_thyroid_physiology0.80544939
63MP0002078_abnormal_glucose_homeostasis0.76835921
64MP0001663_abnormal_digestive_system0.76795500
65MP0004043_abnormal_pH_regulation0.76313342
66MP0003123_paternal_imprinting0.76066158
67MP0005376_homeostasis/metabolism_phenot0.75565295
68MP0005408_hypopigmentation0.75107628
69MP0002136_abnormal_kidney_physiology0.73140773
70MP0009765_abnormal_xenobiotic_induced0.72863638
71MP0005220_abnormal_exocrine_pancreas0.72023269
72MP0010368_abnormal_lymphatic_system0.71544448
73MP0005501_abnormal_skin_physiology0.71098134
74MP0002971_abnormal_brown_adipose0.70509995
75MP0009053_abnormal_anal_canal0.69863030
76MP0005334_abnormal_fat_pad0.64508899
77MP0005266_abnormal_metabolism0.64465165
78MP0005535_abnormal_body_temperature0.64261208
79MP0001661_extended_life_span0.61503684
80MP0004185_abnormal_adipocyte_glucose0.61308988
81MP0009333_abnormal_splenocyte_physiolog0.60825036
82MP0003315_abnormal_perineum_morphology0.60651359
83MP0003329_amyloid_beta_deposits0.58735442
84MP0005377_hearing/vestibular/ear_phenot0.58713007
85MP0003878_abnormal_ear_physiology0.58713007
86MP0004130_abnormal_muscle_cell0.57670651
87MP0006035_abnormal_mitochondrial_morpho0.56649218
88MP0005448_abnormal_energy_balance0.56296618
89MP0004264_abnormal_extraembryonic_tissu0.53526518
90MP0005381_digestive/alimentary_phenotyp0.52827429
91MP0001765_abnormal_ion_homeostasis0.52620559
92MP0002928_abnormal_bile_duct0.51554633
93MP0003690_abnormal_glial_cell0.51399667
94MP0002166_altered_tumor_susceptibility0.49378417
95MP0003638_abnormal_response/metabolism_0.49168202
96MP0005395_other_phenotype0.48813820
97MP0005666_abnormal_adipose_tissue0.48640463
98MP0000639_abnormal_adrenal_gland0.48444350
99MP0005076_abnormal_cell_differentiation0.47360748
100MP0005464_abnormal_platelet_physiology0.46841431
101MP0008260_abnormal_autophagy0.46464929
102MP0002822_catalepsy0.44884664
103MP0003122_maternal_imprinting0.43967766
104MP0002396_abnormal_hematopoietic_system0.43762201
105MP0003718_maternal_effect0.43347946
106MP0008873_increased_physiological_sensi0.42976290
107MP0002796_impaired_skin_barrier0.42866548
108MP0003953_abnormal_hormone_level0.42304138
109MP0005058_abnormal_lysosome_morphology0.41944816
110MP0010234_abnormal_vibrissa_follicle0.37980485
111MP0009115_abnormal_fat_cell0.37578782
112MP0009672_abnormal_birth_weight0.37175304
113MP0005166_decreased_susceptibility_to0.37122283
114MP0000538_abnormal_urinary_bladder0.36470157
115MP0003300_gastrointestinal_ulcer0.36357368
116MP0008874_decreased_physiological_sensi0.36241111
117MP0008872_abnormal_physiological_respon0.35721747
118MP0000230_abnormal_systemic_arterial0.35425047
119MP0003436_decreased_susceptibility_to0.35037873
120MP0002168_other_aberrant_phenotype0.34202195
121MP0005248_abnormal_Harderian_gland0.34150066
122MP0003075_altered_response_to0.33505610
123MP0002135_abnormal_kidney_morphology0.32461091
124MP0009384_cardiac_valve_regurgitation0.31945280
125MP0002970_abnormal_white_adipose0.31076188
126MP0004782_abnormal_surfactant_physiolog0.30829407
127MP0001845_abnormal_inflammatory_respons0.29704389
128MP0003724_increased_susceptibility_to0.29619036
129MP0000249_abnormal_blood_vessel0.28164231
130MP0006082_CNS_inflammation0.27621984
131MP0000579_abnormal_nail_morphology0.27421207
132MP0001243_abnormal_dermal_layer0.24666020
133MP0001881_abnormal_mammary_gland0.24369793

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.00334902
2Intrahepatic cholestasis (HP:0001406)6.83759158
3Deep venous thrombosis (HP:0002625)6.77757237
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.39536596
5Hypobetalipoproteinemia (HP:0003563)6.24053922
6Xanthomatosis (HP:0000991)6.06934552
7Prolonged partial thromboplastin time (HP:0003645)5.83401939
8Hyperlipoproteinemia (HP:0010980)5.01219901
9Complement deficiency (HP:0004431)4.90649244
10Abnormality of glutamine family amino acid metabolism (HP:0010902)4.77476329
11Hyperammonemia (HP:0001987)4.62829105
12Hypolipoproteinemia (HP:0010981)4.60044908
13Hyperglycinemia (HP:0002154)4.38392052
14Ketosis (HP:0001946)4.36713190
15Joint hemorrhage (HP:0005261)4.34805470
16Hyperglycinuria (HP:0003108)4.33640530
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.27994143
18Abnormality of aspartate family amino acid metabolism (HP:0010899)4.22583299
19Epidermoid cyst (HP:0200040)4.17261415
20Abnormality of glycine metabolism (HP:0010895)4.16290329
21Abnormality of serine family amino acid metabolism (HP:0010894)4.16290329
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.13675672
23Abnormality of the common coagulation pathway (HP:0010990)4.06060304
24Fat malabsorption (HP:0002630)4.05493554
25Hypoalphalipoproteinemia (HP:0003233)3.90275512
26Abnormality of methionine metabolism (HP:0010901)3.89575975
27Hypoglycemic coma (HP:0001325)3.77695957
28Abnormality of pyrimidine metabolism (HP:0004353)3.71071364
29Conjugated hyperbilirubinemia (HP:0002908)3.63286528
30Abnormality of complement system (HP:0005339)3.57591841
31Widely patent fontanelles and sutures (HP:0004492)3.55071819
32Abnormality of fatty-acid metabolism (HP:0004359)3.49474518
33Hypercholesterolemia (HP:0003124)3.46931008
34Abnormality of the intrinsic pathway (HP:0010989)3.45106196
35Abnormality of nucleobase metabolism (HP:0010932)3.42122724
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.33336715
37Hyperbilirubinemia (HP:0002904)3.30129620
38Gout (HP:0001997)3.28381976
39Abnormality of purine metabolism (HP:0004352)3.27648403
40Ketoacidosis (HP:0001993)3.27414511
41Delayed CNS myelination (HP:0002188)3.10893649
42Confusion (HP:0001289)3.05204033
43Pigmentary retinal degeneration (HP:0001146)2.98827390
44Abnormality of serum amino acid levels (HP:0003112)2.97681411
45Hepatocellular carcinoma (HP:0001402)2.95883500
46Metabolic acidosis (HP:0001942)2.93715599
47Steatorrhea (HP:0002570)2.92286385
48Malnutrition (HP:0004395)2.84894314
49Cholecystitis (HP:0001082)2.80820090
50Abnormal gallbladder physiology (HP:0012438)2.80820090
51Vascular calcification (HP:0004934)2.76282492
52Spontaneous abortion (HP:0005268)2.71976168
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.71013819
54Dicarboxylic aciduria (HP:0003215)2.71013819
55Myocardial infarction (HP:0001658)2.69796488
56Lethargy (HP:0001254)2.66827200
57Acanthocytosis (HP:0001927)2.66398584
58Hypochromic microcytic anemia (HP:0004840)2.60363709
59Thin bony cortex (HP:0002753)2.60359987
60Abnormal urine phosphate concentration (HP:0012599)2.60212338
61Systemic lupus erythematosus (HP:0002725)2.58719828
62Skin nodule (HP:0200036)2.53649484
63Ileus (HP:0002595)2.53336148
64Wide cranial sutures (HP:0010537)2.51874877
65Proximal tubulopathy (HP:0000114)2.47596817
66Nausea (HP:0002018)2.46050154
67Spastic diplegia (HP:0001264)2.44875604
68Cardiovascular calcification (HP:0011915)2.44381775
69Hypophosphatemia (HP:0002148)2.43948996
70Irritability (HP:0000737)2.43543149
71Abnormal gallbladder morphology (HP:0012437)2.42481095
72Nephritis (HP:0000123)2.42287173
73Generalized aminoaciduria (HP:0002909)2.41105427
74Increased purine levels (HP:0004368)2.40628466
75Hyperuricemia (HP:0002149)2.40628466
76Cholelithiasis (HP:0001081)2.40061456
77Potter facies (HP:0002009)2.40032691
78Facial shape deformation (HP:0011334)2.40032691
79Purpura (HP:0000979)2.39603361
80Hypoglycemic seizures (HP:0002173)2.38531358
81Late onset (HP:0003584)2.37840821
82Hydroxyprolinuria (HP:0003080)2.34579463
83Abnormality of proline metabolism (HP:0010907)2.34579463
84Neonatal onset (HP:0003623)2.33399838
85Alkalosis (HP:0001948)2.31175986
86Hyperphosphaturia (HP:0003109)2.29866027
87Sensorimotor neuropathy (HP:0007141)2.27383516
88Megaloblastic anemia (HP:0001889)2.26108050
89Cerebral edema (HP:0002181)2.26010665
90Enlarged kidneys (HP:0000105)2.25257607
91Flat acetabular roof (HP:0003180)2.24107589
92Vomiting (HP:0002013)2.22089025
93Mitral stenosis (HP:0001718)2.21994152
94Glomerulonephritis (HP:0000099)2.20674339
95Abnormality of the vitamin B12 metabolism (HP:0004341)2.20448094
96Esophageal varix (HP:0002040)2.19836515
97Reticulocytosis (HP:0001923)2.18780598
98Pancreatitis (HP:0001733)2.18027128
99Abdominal distention (HP:0003270)2.17680801
100Rickets (HP:0002748)2.16491835
101Abnormality of urine glucose concentration (HP:0011016)2.14511231
102Glycosuria (HP:0003076)2.14511231
103Abnormality of alkaline phosphatase activity (HP:0004379)2.12396608
104Amyloidosis (HP:0011034)2.10396001
105Delayed epiphyseal ossification (HP:0002663)2.09717066
106Recurrent gram-negative bacterial infections (HP:0005420)2.08310622
107Increased serum ferritin (HP:0003281)2.05754697
108Abnormality of vitamin B metabolism (HP:0004340)2.04631867
109Brushfield spots (HP:0001088)2.04493057
110Abnormality of the gallbladder (HP:0005264)2.03720764
111Cerebral palsy (HP:0100021)2.02974712
112Urinary glycosaminoglycan excretion (HP:0003541)2.02859914
113Mucopolysacchariduria (HP:0008155)2.02859914
114Abnormal enzyme/coenzyme activity (HP:0012379)2.02072758
115Poikilocytosis (HP:0004447)1.99366100
116Opisthotonus (HP:0002179)1.99310737
117Hyperinsulinemic hypoglycemia (HP:0000825)1.96460261
118Hemorrhage of the eye (HP:0011885)1.96352104
119Thrombophlebitis (HP:0004418)1.96231768
120Menorrhagia (HP:0000132)1.95882865
121Prolonged neonatal jaundice (HP:0006579)1.95153713
122Elevated alkaline phosphatase (HP:0003155)1.94749150
123Abnormal cartilage morphology (HP:0002763)1.93961599
124Glomerulosclerosis (HP:0000096)1.93256299
125Abnormal hair laboratory examination (HP:0003328)1.93104199
126Focal segmental glomerulosclerosis (HP:0000097)1.92252442
127Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92144093
128Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92144093
129Abnormality of polysaccharide metabolism (HP:0011012)1.92144093
130Gingival bleeding (HP:0000225)1.91483854
131Vaginal fistula (HP:0004320)1.86569924
132Nephrolithiasis (HP:0000787)1.85824184
133Hypophosphatemic rickets (HP:0004912)1.83088586
134Abnormality of transition element cation homeostasis (HP:0011030)1.82812360
135Abnormality of vitamin metabolism (HP:0100508)1.82672277

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.74264996
2ERN14.79436373
3FGFR44.32433552
4SIK13.92522053
5SMG13.24770320
6TAOK32.70165296
7ERBB42.61599990
8EEF2K2.51794048
9INSRR2.47079089
10MST1R2.46164036
11TESK22.27369400
12PKN22.16752129
13ACVR1B2.06302479
14TRIB32.02148859
15MAPKAPK31.96397786
16MAPK111.91304382
17MAP2K41.88231006
18FRK1.80039386
19LATS11.78286622
20PTK61.70601214
21FLT31.67301630
22WNK41.65645534
23GRK61.59611942
24PDK41.57383727
25PDK31.57383727
26MAP3K101.50021189
27TYK21.45545039
28STK38L1.41311565
29TLK11.33112446
30RPS6KB21.30600337
31PIK3CG1.30010729
32ABL21.27878019
33WNK31.27781429
34NEK91.23205572
35VRK21.18530490
36MAP3K71.17638380
37MAP3K31.14087276
38PRKAA21.11907397
39MATK1.11651616
40KDR1.11022293
41CDK71.07872762
42PIM21.07724361
43PRKD21.07466299
44DAPK21.05783971
45DYRK1B1.04020038
46ICK1.03916318
47JAK21.03810856
48PINK11.02323552
49CDK121.01382969
50TBK11.01274021
51EIF2AK11.00595161
52MAP3K111.00266490
53MAP2K30.98794245
54NME20.98206780
55NME10.97146511
56RIPK10.96861409
57TYRO30.93852287
58MET0.93835895
59ERBB20.93354564
60FGFR20.92713489
61EPHB10.91577721
62TAOK10.90276732
63PRKCZ0.86912757
64PRKCI0.86697005
65MAPK40.85702819
66TNK20.85383152
67MAPK150.84413443
68OXSR10.83846202
69RIPK40.83158504
70PDK20.81819211
71GSK3A0.80479589
72MAP2K60.80037297
73MAP3K140.79017967
74PTK20.78641239
75CDK60.78215328
76PRKAA10.77088934
77JAK10.77059149
78PRKACG0.70945088
79CSK0.69269170
80SGK30.68352832
81STK160.68001220
82DDR20.65876521
83CDC42BPA0.63318344
84PRPF4B0.62925434
85TIE10.62243625
86TESK10.60072592
87CAMK1D0.58559975
88IRAK30.57178165
89MAPK120.56200355
90MAP4K20.56167804
91PDPK10.54461531
92TGFBR20.53320751
93AKT30.53137872
94SIK20.52161476
95HIPK20.51885314
96CAMK2G0.51560877
97NEK10.51437319
98MAP2K20.50379952
99STK390.49955906
100MTOR0.47662504
101SGK4940.47440692
102SGK2230.47440692
103EPHA30.47168050
104BMX0.47052932
105TAOK20.45505682
106CDK40.45401045
107FGFR30.44042855
108PIK3CA0.43643659
109CSF1R0.43535181
110MAPKAPK50.43414523
111MAP3K50.43198665
112MAP2K10.41559363
113IRAK40.41290791
114ARAF0.40479857
115CAMKK10.39685222
116EPHA20.39185471
117PRKCQ0.39062583
118SGK20.38839877
119STK380.38692209
120PDK10.38159626
121MUSK0.37350288
122IKBKE0.35774622
123MAP4K10.35710013
124MAPK70.35554750
125STK30.35009757
126MAP3K130.33826653
127IGF1R0.32544927
128IKBKB0.32420216
129EGFR0.31748114
130NEK20.31668912
131MAP3K80.31622792
132PRKG20.31423827
133GRK10.31365734
134MAP3K60.30736462
135RPS6KA60.29559460
136JAK30.28872995
137PRKD30.28324615
138EPHB20.27806973
139MAP3K10.26910234
140RPS6KL10.26868278
141RPS6KC10.26868278
142RPS6KB10.26641745
143FGR0.26557981
144RET0.26250572
145CHUK0.25766846
146MAPKAPK20.25763785
147CDK90.25250870
148BTK0.24679218
149MAP3K20.24572719
150CAMK40.24518223
151IRAK10.24206858
152PRKCA0.22455835
153PRKCG0.21480870

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.18091279
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.45038794
3Nitrogen metabolism_Homo sapiens_hsa009103.39863814
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.24103356
5Arginine biosynthesis_Homo sapiens_hsa002202.96173835
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.69544810
7Tryptophan metabolism_Homo sapiens_hsa003802.68221947
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.58597718
9Fatty acid degradation_Homo sapiens_hsa000712.52900813
10Complement and coagulation cascades_Homo sapiens_hsa046102.48278966
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.48229918
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.41512654
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.36976471
14Butanoate metabolism_Homo sapiens_hsa006502.21741361
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10488514
16Peroxisome_Homo sapiens_hsa041462.09272064
17Propanoate metabolism_Homo sapiens_hsa006402.00861233
18PPAR signaling pathway_Homo sapiens_hsa033201.90163260
19Chemical carcinogenesis_Homo sapiens_hsa052041.88443553
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87373083
21Histidine metabolism_Homo sapiens_hsa003401.87188791
22Fatty acid metabolism_Homo sapiens_hsa012121.83594139
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.77540169
24beta-Alanine metabolism_Homo sapiens_hsa004101.70913934
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70161711
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.69890514
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68834088
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64318139
29Selenocompound metabolism_Homo sapiens_hsa004501.63080606
30Caffeine metabolism_Homo sapiens_hsa002321.62272139
31Retinol metabolism_Homo sapiens_hsa008301.61980232
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60275292
33Bile secretion_Homo sapiens_hsa049761.59326647
34Pyruvate metabolism_Homo sapiens_hsa006201.57636889
35Staphylococcus aureus infection_Homo sapiens_hsa051501.51126565
36Phenylalanine metabolism_Homo sapiens_hsa003601.47315881
37Other glycan degradation_Homo sapiens_hsa005111.45306867
38Sulfur metabolism_Homo sapiens_hsa009201.42934449
39Starch and sucrose metabolism_Homo sapiens_hsa005001.40931089
40Fat digestion and absorption_Homo sapiens_hsa049751.39414703
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.31652909
42Folate biosynthesis_Homo sapiens_hsa007901.31155223
43Tyrosine metabolism_Homo sapiens_hsa003501.29835987
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.29744972
45Biosynthesis of amino acids_Homo sapiens_hsa012301.29670814
46Carbon metabolism_Homo sapiens_hsa012001.28259903
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27201607
48Fatty acid elongation_Homo sapiens_hsa000621.21726012
49Vitamin digestion and absorption_Homo sapiens_hsa049771.15793939
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15283683
51ABC transporters_Homo sapiens_hsa020101.14723487
52Steroid biosynthesis_Homo sapiens_hsa001001.14209493
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.13558184
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06378702
55Arginine and proline metabolism_Homo sapiens_hsa003301.04022645
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92563851
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91074916
58Sulfur relay system_Homo sapiens_hsa041220.90347006
59Lysine degradation_Homo sapiens_hsa003100.88703529
60Vitamin B6 metabolism_Homo sapiens_hsa007500.87274062
61Glutathione metabolism_Homo sapiens_hsa004800.87099481
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86334274
63Glycerolipid metabolism_Homo sapiens_hsa005610.79198178
64Pentose phosphate pathway_Homo sapiens_hsa000300.77825741
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74244206
66One carbon pool by folate_Homo sapiens_hsa006700.70515209
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60969015
68Sphingolipid metabolism_Homo sapiens_hsa006000.60560674
69Fructose and mannose metabolism_Homo sapiens_hsa000510.53256597
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52861095
71Fatty acid biosynthesis_Homo sapiens_hsa000610.52472195
72N-Glycan biosynthesis_Homo sapiens_hsa005100.49343415
73Metabolic pathways_Homo sapiens_hsa011000.47485335
74Galactose metabolism_Homo sapiens_hsa000520.41273341
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.37791975
76Ether lipid metabolism_Homo sapiens_hsa005650.30780316
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29064099
78Prion diseases_Homo sapiens_hsa050200.25519939
79Insulin resistance_Homo sapiens_hsa049310.22994875
80Asthma_Homo sapiens_hsa053100.21758502
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.21557957
82Linoleic acid metabolism_Homo sapiens_hsa005910.18076104
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.17360990
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.15889345
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15473375
86Base excision repair_Homo sapiens_hsa034100.11962471
87Glucagon signaling pathway_Homo sapiens_hsa049220.11577288
88Renin-angiotensin system_Homo sapiens_hsa046140.10603136
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.07556608
90AMPK signaling pathway_Homo sapiens_hsa041520.04171385
91Pertussis_Homo sapiens_hsa051330.03280512
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.01953767
93Mineral absorption_Homo sapiens_hsa049780.00932661
94Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2416852
95Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2183641
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2147411
97Regulation of autophagy_Homo sapiens_hsa04140-0.1990031
98African trypanosomiasis_Homo sapiens_hsa05143-0.1964141
99Bladder cancer_Homo sapiens_hsa05219-0.1925613
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1716491
101Hepatitis C_Homo sapiens_hsa05160-0.1534839
102Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1475913
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1330193
104Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1267773
105Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1120202
106Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1102753
107Insulin signaling pathway_Homo sapiens_hsa04910-0.1093961
108Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0865680
109Protein digestion and absorption_Homo sapiens_hsa04974-0.0781412
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0712397
111Lysosome_Homo sapiens_hsa04142-0.0192883
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0124062

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