TKT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.16875756
2* pentose-phosphate shunt (GO:0006098)4.88920546
3low-density lipoprotein particle clearance (GO:0034383)4.47112170
4* NADPH regeneration (GO:0006740)4.42794801
5folic acid-containing compound biosynthetic process (GO:0009396)4.34850964
6viral transcription (GO:0019083)4.19447876
7translational termination (GO:0006415)4.03575288
8DNA strand elongation involved in DNA replication (GO:0006271)3.96562807
9protein localization to kinetochore (GO:0034501)3.87594160
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.85721110
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.85721110
12regulation of translational fidelity (GO:0006450)3.84758585
13ribosomal small subunit assembly (GO:0000028)3.80015871
14DNA strand elongation (GO:0022616)3.73009478
15glucose 6-phosphate metabolic process (GO:0051156)3.70943876
16translational elongation (GO:0006414)3.67182104
17response to peptidoglycan (GO:0032494)3.65004499
18IMP biosynthetic process (GO:0006188)3.63495504
19negative regulation of phagocytosis (GO:0050765)3.62277460
20negative regulation of erythrocyte differentiation (GO:0045647)3.60977993
21positive regulation by organism of defense response of other organism involved in symbiotic interact3.57236192
22modulation by symbiont of host immune response (GO:0052553)3.57236192
23positive regulation by symbiont of host defense response (GO:0052509)3.57236192
24modulation by symbiont of host defense response (GO:0052031)3.57236192
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.57236192
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.57236192
27positive regulation of histone deacetylation (GO:0031065)3.57179577
28COPI coating of Golgi vesicle (GO:0048205)3.45179973
29Golgi transport vesicle coating (GO:0048200)3.45179973
30protein complex localization (GO:0031503)3.43403870
31DNA replication initiation (GO:0006270)3.39742864
32pinocytosis (GO:0006907)3.38883666
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.38353351
34mitotic chromosome condensation (GO:0007076)3.38170963
35IMP metabolic process (GO:0046040)3.38070886
36telomere maintenance via semi-conservative replication (GO:0032201)3.35986901
37antigen processing and presentation of endogenous antigen (GO:0019883)3.34844619
38regulation of protein heterodimerization activity (GO:0043497)3.32981633
39translational initiation (GO:0006413)3.31343238
40regulation of translational termination (GO:0006449)3.19186973
41cellular protein complex localization (GO:0034629)3.15951388
42protein localization to chromosome, centromeric region (GO:0071459)3.15035929
43viral life cycle (GO:0019058)3.14759317
44SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.14267676
45positive regulation of Cdc42 GTPase activity (GO:0043089)3.13402737
46mitotic nuclear envelope disassembly (GO:0007077)3.13222500
47cellular protein complex disassembly (GO:0043624)3.13117772
48* glucose catabolic process (GO:0006007)3.12731985
49maternal placenta development (GO:0001893)3.12547646
50activation of Rac GTPase activity (GO:0032863)3.09057320
51regulation of cholesterol storage (GO:0010885)3.08521196
52white fat cell differentiation (GO:0050872)3.08318866
53negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.07080611
54protein targeting to ER (GO:0045047)3.06924151
55protein localization to endosome (GO:0036010)3.06896241
56ribosomal small subunit biogenesis (GO:0042274)3.04822065
57proline biosynthetic process (GO:0006561)3.03376047
58cotranslational protein targeting to membrane (GO:0006613)3.03077885
59regulation of mammary gland epithelial cell proliferation (GO:0033599)3.01917056
60formation of translation preinitiation complex (GO:0001731)3.00230142
61negative regulation of RNA splicing (GO:0033119)2.99833287
62DNA duplex unwinding (GO:0032508)2.99151397
63DNA geometric change (GO:0032392)2.95923403
64protein complex disassembly (GO:0043241)2.95409277
65epithelial cell differentiation involved in prostate gland development (GO:0060742)2.92891664
66defense response to fungus (GO:0050832)2.91386888
67establishment of protein localization to endoplasmic reticulum (GO:0072599)2.91176485
68T cell apoptotic process (GO:0070231)2.90907061
69DNA replication-dependent nucleosome assembly (GO:0006335)2.90609281
70DNA replication-dependent nucleosome organization (GO:0034723)2.90609281
71spliceosomal tri-snRNP complex assembly (GO:0000244)2.90273024
72nucleobase biosynthetic process (GO:0046112)2.89894076
73membrane disassembly (GO:0030397)2.89663045
74nuclear envelope disassembly (GO:0051081)2.89663045
75heterochromatin organization (GO:0070828)2.88714333
76positive regulation of protein deacetylation (GO:0090312)2.88239267
77translesion synthesis (GO:0019985)2.86608518
78Arp2/3 complex-mediated actin nucleation (GO:0034314)2.86458302
79negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.84499465
80protein localization to endoplasmic reticulum (GO:0070972)2.84224625
81valine metabolic process (GO:0006573)2.84165923
82embryonic process involved in female pregnancy (GO:0060136)2.81441355
83peptidyl-arginine omega-N-methylation (GO:0035247)2.80856120
84establishment of integrated proviral latency (GO:0075713)2.79648924
85maturation of SSU-rRNA (GO:0030490)2.79405114
86pore complex assembly (GO:0046931)2.78569457
87cell-substrate adherens junction assembly (GO:0007045)2.78347319
88focal adhesion assembly (GO:0048041)2.78347319
89neutrophil activation involved in immune response (GO:0002283)2.77659747
90response to laminar fluid shear stress (GO:0034616)2.76273135
91regulation of early endosome to late endosome transport (GO:2000641)2.76129312
923-UTR-mediated mRNA stabilization (GO:0070935)2.76000466
93telomere maintenance via recombination (GO:0000722)2.75688438
94adherens junction assembly (GO:0034333)2.75389752
95biotin metabolic process (GO:0006768)2.72679458
96fatty-acyl-CoA biosynthetic process (GO:0046949)2.71575827
97nuclear pore organization (GO:0006999)2.71189715
98protein export from nucleus (GO:0006611)2.70960656
99long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.70085236
100mitotic G1 DNA damage checkpoint (GO:0031571)2.68207086
101mitotic recombination (GO:0006312)2.66762041
102detection of other organism (GO:0098543)2.66486025
103macromolecular complex disassembly (GO:0032984)2.66155333
104acyl-CoA biosynthetic process (GO:0071616)2.65937480
105thioester biosynthetic process (GO:0035384)2.65937480
106respiratory burst (GO:0045730)2.65799548
107ncRNA 3-end processing (GO:0043628)2.64912287
108dosage compensation (GO:0007549)2.64675722
109pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.62436136
110tricarboxylic acid metabolic process (GO:0072350)2.61910942
111negative regulation of mRNA processing (GO:0050686)2.61005570
112regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.60857514
113modulation by virus of host process (GO:0019054)2.60647724
114pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.60588348
115UMP biosynthetic process (GO:0006222)2.60588348
116pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.60588348
117UMP metabolic process (GO:0046049)2.60588348
118intracellular estrogen receptor signaling pathway (GO:0030520)2.59218765
119stress fiber assembly (GO:0043149)2.58768181
120nucleobase-containing small molecule interconversion (GO:0015949)2.58666914
121nuclear pore complex assembly (GO:0051292)2.58575714
122protein retention in ER lumen (GO:0006621)2.58188977
123modulation by symbiont of host cellular process (GO:0044068)2.58050597
124triglyceride catabolic process (GO:0019433)2.57549527
125maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.57432325
126histone arginine methylation (GO:0034969)2.57190286
127sister chromatid segregation (GO:0000819)2.56195115
128detection of bacterium (GO:0016045)2.55196703
129mRNA stabilization (GO:0048255)2.54889199
130RNA stabilization (GO:0043489)2.54889199
131pteridine-containing compound biosynthetic process (GO:0042559)2.54606125
132mitotic sister chromatid segregation (GO:0000070)2.54502968
133mannose metabolic process (GO:0006013)2.54464415
134regulation of histone H3-K9 methylation (GO:0051570)2.54416000
135apoptotic process involved in morphogenesis (GO:0060561)2.53905021
136lymphocyte apoptotic process (GO:0070227)2.53669059
137triglyceride biosynthetic process (GO:0019432)2.53500231
138L-serine metabolic process (GO:0006563)2.52675639
139barbed-end actin filament capping (GO:0051016)2.51485401
140activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.50273588
141negative regulation of mRNA metabolic process (GO:1903312)2.48189881
142response to fungus (GO:0009620)2.47552734
143regulation of superoxide anion generation (GO:0032928)2.46318155
144tetrahydrofolate metabolic process (GO:0046653)2.46168056
145ribosomal large subunit biogenesis (GO:0042273)2.45518224
146response to host (GO:0075136)2.45498025
147response to host defenses (GO:0052200)2.45498025
148response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.45498025
149nuclear envelope organization (GO:0006998)2.44992818
150cellular hyperosmotic response (GO:0071474)2.44440748
151telomere maintenance via telomere lengthening (GO:0010833)2.43681901
152regulation of leukocyte degranulation (GO:0043300)2.42015277
153nucleosome disassembly (GO:0006337)2.41133816
154protein-DNA complex disassembly (GO:0032986)2.41133816
155cell-substrate junction assembly (GO:0007044)2.38980947
156response to host immune response (GO:0052572)2.38631070
157response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.38631070
158L-alpha-amino acid transmembrane transport (GO:1902475)2.36728049
159establishment of viral latency (GO:0019043)2.33720555
160retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.32390982
161cellular response to interleukin-4 (GO:0071353)2.30544663
162response to muramyl dipeptide (GO:0032495)2.27705888
163cellular response to epidermal growth factor stimulus (GO:0071364)2.26532849
164protein maturation by protein folding (GO:0022417)2.26491140
165positive regulation of gamma-delta T cell activation (GO:0046645)2.24507421
166regulation of RNA export from nucleus (GO:0046831)2.23998716
167basement membrane organization (GO:0071711)2.22816187
168positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.21893737
169pre-miRNA processing (GO:0031054)2.21671387
170mRNA transcription from RNA polymerase II promoter (GO:0042789)2.20979248
171planar cell polarity pathway involved in neural tube closure (GO:0090179)2.18173075
172leukocyte aggregation (GO:0070486)2.17698763

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.52185802
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.72759531
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.70436232
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.42780715
5MYC_22102868_ChIP-Seq_BL_Human2.87956913
6* MYC_18555785_ChIP-Seq_MESCs_Mouse2.77637470
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.67515613
8VDR_21846776_ChIP-Seq_THP-1_Human2.52775115
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42647278
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.14736798
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.09422427
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.04777676
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.79767367
14* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78307294
15TP63_17297297_ChIP-ChIP_HaCaT_Human1.75388826
16XRN2_22483619_ChIP-Seq_HELA_Human1.75068694
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74948350
18* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74742952
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72461572
20MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69436378
21AR_21909140_ChIP-Seq_LNCAP_Human1.67792190
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66920289
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.65093174
24* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62556761
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55326299
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54154285
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53540771
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.52202323
29* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51034078
30CLOCK_20551151_ChIP-Seq_293T_Human1.49594710
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49410942
32* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48898917
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.47536256
34STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47106305
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45848297
36SCL_19346495_ChIP-Seq_HPC-7_Human1.42211537
37VDR_24763502_ChIP-Seq_THP-1_Human1.41717452
38* MAF_26560356_Chip-Seq_TH1_Human1.40938254
39UTX_26944678_Chip-Seq_JUKART_Human1.39146411
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39140170
41TCF7_22412390_ChIP-Seq_EML_Mouse1.38829722
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37295963
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36127998
44CIITA_25753668_ChIP-Seq_RAJI_Human1.34514962
45ZNF263_19887448_ChIP-Seq_K562_Human1.33350216
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.31735213
47ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.27954027
48CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.27661896
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26093229
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25342113
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25317100
52CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24422885
53HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.23832997
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23731656
55* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23472473
56KDM2B_26808549_Chip-Seq_DND41_Human1.23102776
57* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22242970
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22210880
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22174946
60KDM5A_27292631_Chip-Seq_BREAST_Human1.22055150
61RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21679881
62* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21536658
63* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21452882
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20576655
65* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20516192
66* RUNX1_22412390_ChIP-Seq_EML_Mouse1.19745997
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19569536
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19355809
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18663288
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18035921
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17212179
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16652290
73* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16116475
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16071955
75* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16049002
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15547413
77SPI1_23547873_ChIP-Seq_NB4_Human1.15464113
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15447716
79LXR_22292898_ChIP-Seq_THP-1_Human1.13478177
80THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12925861
81EST1_17652178_ChIP-ChIP_JURKAT_Human1.12070036
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10332537
83MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09626829
84SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08932490
85TFEB_21752829_ChIP-Seq_HELA_Human1.08863541
86P68_20966046_ChIP-Seq_HELA_Human1.08842301
87ATF3_27146783_Chip-Seq_COLON_Human1.08573086
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08360629
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08147271
90MAF_26560356_Chip-Seq_TH2_Human1.07817655
91TET1_21451524_ChIP-Seq_MESCs_Mouse1.07190520
92E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06641820
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06133896
94DCP1A_22483619_ChIP-Seq_HELA_Human1.04959120
95PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04656884
96RACK7_27058665_Chip-Seq_MCF-7_Human1.04428178
97NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04307264
98HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04238584
99FOXP3_21729870_ChIP-Seq_TREG_Human1.04088756
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03808186
101KDM2B_26808549_Chip-Seq_K562_Human1.03460689
102KDM2B_26808549_Chip-Seq_JURKAT_Human1.03354617
103* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02760825
104* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02565075
105* MYB_26560356_Chip-Seq_TH2_Human1.02396142
106GABP_19822575_ChIP-Seq_HepG2_Human1.01471312
107HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01352298
108SA1_27219007_Chip-Seq_ERYTHROID_Human1.00801317
109VDR_23849224_ChIP-Seq_CD4+_Human1.00650138
110MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00469053
111KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00356134
112MYB_26560356_Chip-Seq_TH1_Human1.00350580
113EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00343875
114NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99435537
115SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98391577
116NCOR1_26117541_ChIP-Seq_K562_Human0.96995018
117SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96509547
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96301567
119CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96116324
120TTF2_22483619_ChIP-Seq_HELA_Human0.95854502
121* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93958430
122E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89801467
123* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89361315
124KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86346022
125IRF8_22096565_ChIP-ChIP_GC-B_Human0.86062787
126JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.85296575
127CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.84590279

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps2.97861095
2MP0008260_abnormal_autophagy2.84245905
3MP0002877_abnormal_melanocyte_morpholog2.72396914
4MP0003705_abnormal_hypodermis_morpholog2.67662448
5MP0003303_peritoneal_inflammation2.66209394
6MP0004185_abnormal_adipocyte_glucose2.54280268
7MP0005670_abnormal_white_adipose2.53065868
8MP0003300_gastrointestinal_ulcer2.47816294
9MP0003693_abnormal_embryo_hatching2.44437130
10MP0002396_abnormal_hematopoietic_system2.42043442
11MP0005451_abnormal_body_composition2.40408761
12MP0005666_abnormal_adipose_tissue2.37190690
13MP0004957_abnormal_blastocyst_morpholog2.35974157
14MP0003111_abnormal_nucleus_morphology2.28331832
15MP0010307_abnormal_tumor_latency2.19477028
16MP0005076_abnormal_cell_differentiation2.11779387
17MP0010094_abnormal_chromosome_stability2.09203569
18MP0004858_abnormal_nervous_system2.07279779
19MP0003077_abnormal_cell_cycle1.96650806
20MP0001545_abnormal_hematopoietic_system1.95705593
21MP0005397_hematopoietic_system_phenotyp1.95705593
22MP0009840_abnormal_foam_cell1.94002338
23MP0000490_abnormal_crypts_of1.88022994
24MP0003566_abnormal_cell_adhesion1.87894904
25MP0009278_abnormal_bone_marrow1.87094241
26MP0004233_abnormal_muscle_weight1.81891298
27MP0001730_embryonic_growth_arrest1.70974765
28MP0003453_abnormal_keratinocyte_physiol1.64700478
29MP0003436_decreased_susceptibility_to1.62468442
30MP0002796_impaired_skin_barrier1.61425128
31MP0010234_abnormal_vibrissa_follicle1.61056324
32MP0005375_adipose_tissue_phenotype1.60629866
33MP0004130_abnormal_muscle_cell1.57270122
34MP0000685_abnormal_immune_system1.52565944
35MP0003191_abnormal_cellular_cholesterol1.51180410
36MP0000350_abnormal_cell_proliferation1.46091027
37MP0004808_abnormal_hematopoietic_stem1.42637020
38MP0006054_spinal_hemorrhage1.41282219
39MP0005464_abnormal_platelet_physiology1.39735479
40MP0003806_abnormal_nucleotide_metabolis1.37363462
41MP0008057_abnormal_DNA_replication1.36641169
42* MP0002970_abnormal_white_adipose1.36411431
43MP0001881_abnormal_mammary_gland1.36202306
44MP0010329_abnormal_lipoprotein_level1.35152820
45MP0000858_altered_metastatic_potential1.34170375
46MP0003656_abnormal_erythrocyte_physiolo1.33597457
47MP0009333_abnormal_splenocyte_physiolog1.31141682
48MP0002398_abnormal_bone_marrow1.30938181
49MP0000465_gastrointestinal_hemorrhage1.29606416
50MP0009115_abnormal_fat_cell1.27423004
51MP0002971_abnormal_brown_adipose1.27289949
52MP0002019_abnormal_tumor_incidence1.26465377
53MP0001873_stomach_inflammation1.25253375
54MP0008438_abnormal_cutaneous_collagen1.25229881
55MP0001915_intracranial_hemorrhage1.24601954
56MP0002722_abnormal_immune_system1.24193056
57MP0003091_abnormal_cell_migration1.23832592
58MP0005621_abnormal_cell_physiology1.22772398
59MP0002166_altered_tumor_susceptibility1.21481321
60MP0005023_abnormal_wound_healing1.20767897
61MP0000689_abnormal_spleen_morphology1.19499150
62MP0000609_abnormal_liver_physiology1.18417553
63MP0002060_abnormal_skin_morphology1.18038275
64MP0001853_heart_inflammation1.17017093
65MP0001835_abnormal_antigen_presentation1.16832814
66* MP0002080_prenatal_lethality1.14318293
67MP0005623_abnormal_meninges_morphology1.13090375
68MP0005058_abnormal_lysosome_morphology1.12315714
69MP0005025_abnormal_response_to1.12111580
70MP0002429_abnormal_blood_cell1.09937410
71MP0001800_abnormal_humoral_immune1.09227058
72MP0004197_abnormal_fetal_growth/weight/1.09084318
73MP0003828_pulmonary_edema1.08811790
74MP0003448_altered_tumor_morphology1.08475609
75MP0010155_abnormal_intestine_physiology1.07104170
76MP0003984_embryonic_growth_retardation1.05628980
77MP0001849_ear_inflammation1.05526296
78MP0002419_abnormal_innate_immunity1.05415682
79MP0001672_abnormal_embryogenesis/_devel1.05322077
80MP0005380_embryogenesis_phenotype1.05322077
81MP0002088_abnormal_embryonic_growth/wei1.04098874
82MP0002452_abnormal_antigen_presenting1.03685001
83MP0002420_abnormal_adaptive_immunity1.02519390
84MP0003186_abnormal_redox_activity1.01629926
85MP0000716_abnormal_immune_system1.01575895
86MP0002086_abnormal_extraembryonic_tissu1.01472522
87MP0002405_respiratory_system_inflammati1.01188287
88MP0001819_abnormal_immune_cell1.01131338
89MP0004947_skin_inflammation1.00974778
90MP0001697_abnormal_embryo_size1.00627628
91MP0008007_abnormal_cellular_replicative1.00558854
92MP0000477_abnormal_intestine_morphology1.00527918
93MP0000678_abnormal_parathyroid_gland0.99687543
94MP0004272_abnormal_basement_membrane0.97632713
95MP0005384_cellular_phenotype0.95489962
96MP0003172_abnormal_lysosome_physiology0.95252555
97MP0005083_abnormal_biliary_tract0.94172181
98MP0008932_abnormal_embryonic_tissue0.94063098
99MP0005257_abnormal_intraocular_pressure0.93585550
100MP0009785_altered_susceptibility_to0.93564860
101MP0000703_abnormal_thymus_morphology0.92779398
102MP0009672_abnormal_birth_weight0.92392270
103MP0000537_abnormal_urethra_morphology0.92287769
104MP0003123_paternal_imprinting0.91777281
105MP0002132_abnormal_respiratory_system0.91352966
106MP0000313_abnormal_cell_death0.91349988
107MP0001348_abnormal_lacrimal_gland0.90970666
108MP0005334_abnormal_fat_pad0.90736435
109MP0001216_abnormal_epidermal_layer0.90187578
110MP0003763_abnormal_thymus_physiology0.89791210
111MP0001661_extended_life_span0.88618911
112MP0003866_abnormal_defecation0.88444240
113MP0009053_abnormal_anal_canal0.88389516
114MP0001851_eye_inflammation0.87826690
115MP0005501_abnormal_skin_physiology0.87566479
116* MP0000598_abnormal_liver_morphology0.87134834
117MP0000003_abnormal_adipose_tissue0.86383052
118MP0001533_abnormal_skeleton_physiology0.84651754
119MP0002006_tumorigenesis0.84044903
120MP0002085_abnormal_embryonic_tissue0.83890876
121MP0002723_abnormal_immune_serum0.83876874
122MP0002254_reproductive_system_inflammat0.83805078
123MP0009931_abnormal_skin_appearance0.83799201
124MP0010030_abnormal_orbit_morphology0.83145025
125MP0002998_abnormal_bone_remodeling0.82895703
126MP0003221_abnormal_cardiomyocyte_apopto0.82895661
127MP0004264_abnormal_extraembryonic_tissu0.81472082
128MP0003941_abnormal_skin_development0.81322781
129MP0001845_abnormal_inflammatory_respons0.80925940
130MP0002009_preneoplasia0.80859211

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)3.32882037
2Reticulocytopenia (HP:0001896)3.31492726
3Abnormal number of erythroid precursors (HP:0012131)3.12472936
4Vertebral compression fractures (HP:0002953)3.05063619
5Thrombocytosis (HP:0001894)3.01625362
6Multiple enchondromatosis (HP:0005701)2.97205787
7Eczematoid dermatitis (HP:0000976)2.84153878
8Broad face (HP:0000283)2.74525778
9Spastic diplegia (HP:0001264)2.66569633
10Hyperacusis (HP:0010780)2.66524675
11Selective tooth agenesis (HP:0001592)2.64556397
12Cellulitis (HP:0100658)2.60136603
13Long palpebral fissure (HP:0000637)2.60001397
14Ependymoma (HP:0002888)2.59391669
15Abnormal platelet volume (HP:0011876)2.57822903
16Chronic otitis media (HP:0000389)2.56977420
17Hypertriglyceridemia (HP:0002155)2.51167461
18Premature rupture of membranes (HP:0001788)2.46666058
19Abnormality of reticulocytes (HP:0004312)2.46634310
20Increased mean platelet volume (HP:0011877)2.43995771
21Cholecystitis (HP:0001082)2.40105340
22Abnormal gallbladder physiology (HP:0012438)2.40105340
23Increased density of long bones (HP:0006392)2.37493446
24Increased connective tissue (HP:0009025)2.35000932
25Petechiae (HP:0000967)2.34048734
26Disproportionate tall stature (HP:0001519)2.33160303
27Recurrent abscess formation (HP:0002722)2.30242128
28Protrusio acetabuli (HP:0003179)2.27620499
29Interstitial pulmonary disease (HP:0006530)2.25544755
30Subacute progressive viral hepatitis (HP:0006572)2.25345542
31Upper motor neuron abnormality (HP:0002127)2.24012736
32IgM deficiency (HP:0002850)2.23488829
33Abnormality of oral frenula (HP:0000190)2.22090231
34Achilles tendon contracture (HP:0001771)2.20846065
35Pallor (HP:0000980)2.18661140
36Distal lower limb amyotrophy (HP:0008944)2.18652529
37Ulnar bowing (HP:0003031)2.15947246
38High pitched voice (HP:0001620)2.14407682
39Ankyloglossia (HP:0010296)2.14124612
40Pseudobulbar signs (HP:0002200)2.13568636
41Recurrent bacterial skin infections (HP:0005406)2.13486462
42Basal cell carcinoma (HP:0002671)2.04852814
43Micronodular cirrhosis (HP:0001413)2.02488992
44Hyperglycinuria (HP:0003108)2.02479860
45Metaphyseal cupping (HP:0003021)2.02030629
46Cerebral aneurysm (HP:0004944)2.01705722
47Progressive muscle weakness (HP:0003323)2.01198483
48Macrocytic anemia (HP:0001972)2.00849518
49Autoimmune thrombocytopenia (HP:0001973)2.00109098
50Centrally nucleated skeletal muscle fibers (HP:0003687)2.00105638
51Rhabdomyolysis (HP:0003201)1.99219644
52Reticulocytosis (HP:0001923)1.98901451
53Angiofibromas (HP:0010615)1.98852557
54Adenoma sebaceum (HP:0009720)1.98852557
55Rectal prolapse (HP:0002035)1.98634691
56Myocardial infarction (HP:0001658)1.98049089
57Acanthosis nigricans (HP:0000956)1.95630231
58Ankle contracture (HP:0006466)1.95375941
59Progressive external ophthalmoplegia (HP:0000590)1.95055975
60Recurrent fungal infections (HP:0002841)1.94743686
61Verrucae (HP:0200043)1.94076059
62Papilloma (HP:0012740)1.94076059
63Agnosia (HP:0010524)1.93542408
64Cutaneous melanoma (HP:0012056)1.92267735
65Gastrointestinal inflammation (HP:0004386)1.92211728
66Flat acetabular roof (HP:0003180)1.91349131
67Colon cancer (HP:0003003)1.90863042
68Abnormality of the Achilles tendon (HP:0005109)1.90159216
69Hepatosplenomegaly (HP:0001433)1.89824051
70Chronic obstructive pulmonary disease (HP:0006510)1.89195122
71Obstructive lung disease (HP:0006536)1.89195122
72Viral hepatitis (HP:0006562)1.89192102
73Hand muscle atrophy (HP:0009130)1.89112975
74Increased serum ferritin (HP:0003281)1.89068096
75Impaired platelet aggregation (HP:0003540)1.88233131
76Abnormal platelet function (HP:0011869)1.88233131
77Nasal polyposis (HP:0100582)1.88070162
78Recurrent viral infections (HP:0004429)1.87437312
79Gingivitis (HP:0000230)1.87130118
80Short nail (HP:0001799)1.86928480
81Elevated erythrocyte sedimentation rate (HP:0003565)1.86355126
82Prolonged bleeding time (HP:0003010)1.83136087
83Pustule (HP:0200039)1.82814635
84Abnormality of glycine metabolism (HP:0010895)1.80706583
85Abnormality of serine family amino acid metabolism (HP:0010894)1.80706583
86Abnormality of T cell physiology (HP:0011840)1.80495546
87Ragged-red muscle fibers (HP:0003200)1.79869034
88Deviation of the thumb (HP:0009603)1.79663303
89Proximal placement of thumb (HP:0009623)1.79583422
90Polygenic inheritance (HP:0010982)1.79128316
91Increased neuronal autofluorescent lipopigment (HP:0002074)1.78223951
92Asymmetry of the thorax (HP:0001555)1.78118012
93Syringomyelia (HP:0003396)1.77895976
94Spinal cord lesions (HP:0100561)1.77895976
95Abnormality of the thoracic spine (HP:0100711)1.77291566
96Segmental peripheral demyelination/remyelination (HP:0003481)1.76556975
97Recurrent gram-negative bacterial infections (HP:0005420)1.76285586
98Poikiloderma (HP:0001029)1.75302060
99Increased nuchal translucency (HP:0010880)1.75119645
100Abnormality of macrophages (HP:0004311)1.74801355
101Shallow orbits (HP:0000586)1.73416523
102Loss of speech (HP:0002371)1.73117937
103Abnormality of the nasal mucosa (HP:0000433)1.72300271
104Distal lower limb muscle weakness (HP:0009053)1.71793264
105Biconcave vertebral bodies (HP:0004586)1.71687788
106Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.71284701
107Abnormality of the distal phalanges of the toes (HP:0010182)1.71261539
108Amyloidosis (HP:0011034)1.71233807
109Fatigue (HP:0012378)1.70957544
110Osteolytic defects of the phalanges of the hand (HP:0009771)1.70900013
111Osteolytic defects of the hand bones (HP:0009699)1.70900013
112Astrocytoma (HP:0009592)1.69382727
113Abnormality of the astrocytes (HP:0100707)1.69382727
114Abnormality of subcutaneous fat tissue (HP:0001001)1.68003939
115Inflammation of the large intestine (HP:0002037)1.67672938
116Increased cerebral lipofuscin (HP:0011813)1.67261824
117Amaurosis fugax (HP:0100576)1.66703835
118Abnormality of the calcaneus (HP:0008364)1.66426030
119Colitis (HP:0002583)1.65846110
120Urticaria (HP:0001025)1.65632584
121Broad distal phalanx of finger (HP:0009836)1.65605983
122Abnormality of the distal phalanx of the thumb (HP:0009617)1.64967842
123Dysmetric saccades (HP:0000641)1.64938237
124Arnold-Chiari malformation (HP:0002308)1.64602269
125Pointed chin (HP:0000307)1.63945962
126Abnormality of the peritoneum (HP:0002585)1.63535044
127Thoracic kyphosis (HP:0002942)1.61368785
128Slow saccadic eye movements (HP:0000514)1.61321520
129Elfin facies (HP:0004428)1.60955043
130Large hands (HP:0001176)1.59993128
131Rough bone trabeculation (HP:0100670)1.59853738
132Short 4th metacarpal (HP:0010044)1.59772305
133Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.59772305
134Myoglobinuria (HP:0002913)1.59606984
135Back pain (HP:0003418)1.59588093
136Insulin resistance (HP:0000855)1.59558627
137Blue sclerae (HP:0000592)1.59456852
138Polycythemia (HP:0001901)1.59441341
139Microvesicular hepatic steatosis (HP:0001414)1.59255155
140Skin ulcer (HP:0200042)1.58658561
141Abnormal cartilage morphology (HP:0002763)1.58469573
142Fasciculations (HP:0002380)1.58058208
143Abnormality of iron homeostasis (HP:0011031)1.57813016
144Pathologic fracture (HP:0002756)1.57556448
145Patellar dislocation (HP:0002999)1.57493950
146Increased IgE level (HP:0003212)1.56623302
147Bowing of the arm (HP:0006488)1.56577882
148Bowed forearm bones (HP:0003956)1.56577882
149Fibroma (HP:0010614)1.56519109
150Lower limb amyotrophy (HP:0007210)1.56220909
151Enlarged penis (HP:0000040)1.55570586
152Myositis (HP:0100614)1.55112720
153Oral leukoplakia (HP:0002745)1.54725549
154Trismus (HP:0000211)1.54322689
155Cervical subluxation (HP:0003308)1.54223279
156Abnormality of T cells (HP:0002843)1.53328539
157Distal upper limb amyotrophy (HP:0007149)1.53159630
158Upper limb amyotrophy (HP:0009129)1.53159630
159Insomnia (HP:0100785)1.52888230
160Mediastinal lymphadenopathy (HP:0100721)1.52670655
161Abnormal vertebral ossification (HP:0100569)1.52160034
162Gastrointestinal dysmotility (HP:0002579)1.51314982
163Advanced eruption of teeth (HP:0006288)1.51002638
164Flared metaphyses (HP:0003015)1.50885733

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.36593125
2EEF2K4.33904014
3SMG14.16307941
4PKN23.72145579
5PRPF4B2.87794791
6CAMK1D2.73490474
7MAP3K102.38382021
8IRAK32.33741758
9ERN12.26908956
10CDC72.18045406
11MAP4K12.14404843
12SCYL22.13395136
13LRRK22.12958974
14TESK22.11931600
15SIK12.01714975
16STK101.88468371
17NEK21.84236999
18RPS6KB21.83496210
19WEE11.72589398
20RIPK41.69658715
21FLT31.64613221
22CAMK1G1.63731806
23PAK41.57099114
24BUB11.56575938
25IRAK41.55565805
26GRK61.54156638
27BCKDK1.50978526
28CDK121.49872885
29MST1R1.45761169
30MAP3K81.43743860
31PTK61.40560614
32NEK11.39862515
33CDK41.35244339
34KSR21.34980831
35NME21.33123352
36ALK1.28986690
37CDK61.25007976
38EPHB11.19788051
39TAOK21.18768004
40MAP3K31.17279192
41BTK1.13996595
42RIPK11.13812609
43BMX1.13271897
44BLK1.10946567
45MAP3K131.10796350
46ARAF1.06794794
47RPS6KA41.03195305
48TSSK61.02559230
49CSF1R0.98605853
50PASK0.98378183
51LATS20.96789901
52CDK70.96636530
53TTN0.96179802
54TESK10.96059240
55IRAK20.94583539
56MAP2K30.93162655
57TTK0.92810346
58PBK0.92721305
59ZAP700.89764927
60EPHA20.85056797
61BRAF0.83761311
62MAP3K10.83239150
63MTOR0.83152034
64TLK10.83016450
65PTK20.80472512
66ILK0.79395033
67PIM10.78963735
68FGR0.78729715
69VRK20.78459025
70ERBB40.77952117
71TGFBR10.77631553
72PRKD20.77414590
73KIT0.76979337
74ATR0.75721189
75MAPKAPK30.75697721
76TYK20.75236126
77EIF2AK10.74314964
78JAK30.73720936
79PDPK10.73279047
80PAK20.72979628
81MARK20.72671217
82STK40.69680198
83MATK0.69344773
84MAPK110.68897080
85KDR0.68359025
86AURKB0.67611175
87CLK10.65696837
88MAP3K110.65358251
89ICK0.65301860
90CDK190.64094858
91TBK10.63171660
92MET0.62702326
93RAF10.62516764
94PIM20.61632195
95MAP3K90.59978083
96CSK0.59565849
97PAK10.58728799
98RPS6KA20.57063945
99JAK20.56538068
100SIK30.53360848
101CHEK10.53332542
102CHEK20.52929045
103DYRK30.52373276
104PLK10.51856717
105FGFR40.51358113
106NTRK10.51117751
107CDK90.51088942
108MAP3K60.49866354
109YES10.47641266
110SRPK10.47456910
111PDK30.46122249
112PDK40.46122249
113TNK20.45213954
114HCK0.45088666
115AKT20.44517777
116SYK0.43087498
117MAP3K140.42944827
118PDGFRA0.42013480
119BRSK20.41288470
120CDC42BPA0.40656151
121AURKA0.40566843
122LCK0.39924402
123MAP2K20.39499226
124LMTK20.39476435
125CDK20.39047192
126RPS6KC10.38165784
127RPS6KL10.38165784
128RPS6KA10.37806198
129ACVR1B0.37370872
130RPS6KA60.37167944
131PRKAA20.36746440
132FGFR10.36336278
133RET0.36230024
134PRKG20.35470902
135TAOK10.34756703
136CSNK2A20.34571916
137FES0.33921517

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.91563346
2Fatty acid biosynthesis_Homo sapiens_hsa000612.85794444
3Mismatch repair_Homo sapiens_hsa034302.69638197
4One carbon pool by folate_Homo sapiens_hsa006702.38805998
5Ribosome_Homo sapiens_hsa030102.34004685
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.25420598
7Other glycan degradation_Homo sapiens_hsa005112.14837588
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.12496422
9Base excision repair_Homo sapiens_hsa034101.85088644
10* Carbon metabolism_Homo sapiens_hsa012001.84736145
11Spliceosome_Homo sapiens_hsa030401.81753052
12Fatty acid metabolism_Homo sapiens_hsa012121.76025826
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74709050
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74548252
15* Pentose phosphate pathway_Homo sapiens_hsa000301.70156646
16Propanoate metabolism_Homo sapiens_hsa006401.60600439
17* Biosynthesis of amino acids_Homo sapiens_hsa012301.56057755
18Caffeine metabolism_Homo sapiens_hsa002321.55962502
19Cell cycle_Homo sapiens_hsa041101.52084297
20Pyruvate metabolism_Homo sapiens_hsa006201.51407246
21RNA transport_Homo sapiens_hsa030131.48877804
22PPAR signaling pathway_Homo sapiens_hsa033201.47103352
23Sulfur relay system_Homo sapiens_hsa041221.43026120
24Fatty acid degradation_Homo sapiens_hsa000711.39574042
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.36611741
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34907368
27Endometrial cancer_Homo sapiens_hsa052131.31437236
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28279832
29Nucleotide excision repair_Homo sapiens_hsa034201.27809352
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.24234349
31Chronic myeloid leukemia_Homo sapiens_hsa052201.21627667
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21244966
33Homologous recombination_Homo sapiens_hsa034401.20098826
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18522188
35Adherens junction_Homo sapiens_hsa045201.09467588
36Acute myeloid leukemia_Homo sapiens_hsa052211.09351390
37Antigen processing and presentation_Homo sapiens_hsa046121.09299475
38Viral carcinogenesis_Homo sapiens_hsa052031.06917784
39Systemic lupus erythematosus_Homo sapiens_hsa053221.05152754
40Fat digestion and absorption_Homo sapiens_hsa049751.04674107
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04372730
42Renal cell carcinoma_Homo sapiens_hsa052111.03153551
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03000145
44Nitrogen metabolism_Homo sapiens_hsa009101.02897985
45Glycerolipid metabolism_Homo sapiens_hsa005611.01769117
46Small cell lung cancer_Homo sapiens_hsa052220.98572530
47AMPK signaling pathway_Homo sapiens_hsa041520.97450192
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96996745
49Leishmaniasis_Homo sapiens_hsa051400.96339423
50Thyroid cancer_Homo sapiens_hsa052160.91884902
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91876463
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90583346
53Galactose metabolism_Homo sapiens_hsa000520.90124055
54Legionellosis_Homo sapiens_hsa051340.88469619
55Selenocompound metabolism_Homo sapiens_hsa004500.87732627
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.87643662
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.87078997
58Influenza A_Homo sapiens_hsa051640.87032736
59Vitamin B6 metabolism_Homo sapiens_hsa007500.86817971
60p53 signaling pathway_Homo sapiens_hsa041150.86712526
61Prostate cancer_Homo sapiens_hsa052150.86298720
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85229784
63Salmonella infection_Homo sapiens_hsa051320.85062296
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.83620702
65Hepatitis C_Homo sapiens_hsa051600.82437701
66B cell receptor signaling pathway_Homo sapiens_hsa046620.82136536
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82045758
68Fructose and mannose metabolism_Homo sapiens_hsa000510.82008709
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.81422920
70Bladder cancer_Homo sapiens_hsa052190.79903163
71Lysine degradation_Homo sapiens_hsa003100.78644407
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78570017
73Apoptosis_Homo sapiens_hsa042100.78504364
74Glutathione metabolism_Homo sapiens_hsa004800.77347338
75ErbB signaling pathway_Homo sapiens_hsa040120.76480272
76Glioma_Homo sapiens_hsa052140.76280089
77Amoebiasis_Homo sapiens_hsa051460.75162496
78Tuberculosis_Homo sapiens_hsa051520.73707365
79Pyrimidine metabolism_Homo sapiens_hsa002400.72865287
80Shigellosis_Homo sapiens_hsa051310.72111912
81HIF-1 signaling pathway_Homo sapiens_hsa040660.71494030
82Lysosome_Homo sapiens_hsa041420.71376896
83Endocytosis_Homo sapiens_hsa041440.71282885
84Non-small cell lung cancer_Homo sapiens_hsa052230.71012292
85Prion diseases_Homo sapiens_hsa050200.70238668
86Pancreatic cancer_Homo sapiens_hsa052120.68712961
87Insulin resistance_Homo sapiens_hsa049310.67668090
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67210834
89Renin-angiotensin system_Homo sapiens_hsa046140.66896149
90mRNA surveillance pathway_Homo sapiens_hsa030150.66842741
91HTLV-I infection_Homo sapiens_hsa051660.65024260
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64376128
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.63503978
94Primary immunodeficiency_Homo sapiens_hsa053400.62619567
95Herpes simplex infection_Homo sapiens_hsa051680.62497581
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.62403652
97Non-homologous end-joining_Homo sapiens_hsa034500.62019145
98Focal adhesion_Homo sapiens_hsa045100.61971745
99Malaria_Homo sapiens_hsa051440.61797204
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61575266
101Toxoplasmosis_Homo sapiens_hsa051450.61532910
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60969437
103Insulin signaling pathway_Homo sapiens_hsa049100.60799207
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60136178
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58834182
106mTOR signaling pathway_Homo sapiens_hsa041500.58655698
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57981826
108MicroRNAs in cancer_Homo sapiens_hsa052060.56736567
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55747474
110Folate biosynthesis_Homo sapiens_hsa007900.55722399
111Osteoclast differentiation_Homo sapiens_hsa043800.55156030
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54738167
113beta-Alanine metabolism_Homo sapiens_hsa004100.54571178
114Inositol phosphate metabolism_Homo sapiens_hsa005620.53150627
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52905892
116Hepatitis B_Homo sapiens_hsa051610.52856162
117N-Glycan biosynthesis_Homo sapiens_hsa005100.52578954
118Epstein-Barr virus infection_Homo sapiens_hsa051690.52483423
119Colorectal cancer_Homo sapiens_hsa052100.52020506
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50451298
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49959396
122Notch signaling pathway_Homo sapiens_hsa043300.49128095
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48999874
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.47744056
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46921348
126Viral myocarditis_Homo sapiens_hsa054160.46568636
127Proteoglycans in cancer_Homo sapiens_hsa052050.46265793
128Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46221994
129Measles_Homo sapiens_hsa051620.45411332
130VEGF signaling pathway_Homo sapiens_hsa043700.44246614
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42218044
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.40830787
133Platelet activation_Homo sapiens_hsa046110.40554771
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39115973

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