TKTL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.99490625
2sperm-egg recognition (GO:0035036)9.71606438
3synaptonemal complex organization (GO:0070193)9.59094573
4synaptonemal complex assembly (GO:0007130)9.54902009
5sperm motility (GO:0030317)9.42948039
6DNA methylation involved in gamete generation (GO:0043046)8.89120132
7binding of sperm to zona pellucida (GO:0007339)8.86769219
8plasma membrane fusion (GO:0045026)8.70771308
9cell-cell recognition (GO:0009988)8.67969783
10acrosome reaction (GO:0007340)8.36803431
11motile cilium assembly (GO:0044458)8.28036340
12epithelial cilium movement (GO:0003351)7.99221999
13cell wall macromolecule catabolic process (GO:0016998)7.90184249
14cell wall macromolecule metabolic process (GO:0044036)7.90184249
15reproduction (GO:0000003)7.89631279
16spermatid development (GO:0007286)7.88836151
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.65391935
18regulation of histone H3-K27 methylation (GO:0061085)7.59123378
19cilium movement (GO:0003341)7.30161495
20chromosome organization involved in meiosis (GO:0070192)7.12805072
21male meiosis I (GO:0007141)6.92547692
22meiotic nuclear division (GO:0007126)6.87320449
23single fertilization (GO:0007338)6.35315695
24regulation of cilium movement (GO:0003352)6.25044546
25meiotic cell cycle (GO:0051321)6.19145592
26fertilization (GO:0009566)5.78531084
27microtubule depolymerization (GO:0007019)5.73435590
28meiosis I (GO:0007127)5.68988300
29regulation of glycoprotein biosynthetic process (GO:0010559)5.64666602
30sperm capacitation (GO:0048240)5.62027376
31B cell proliferation (GO:0042100)5.60645684
32gene silencing by RNA (GO:0031047)5.58019357
33regulation of meiosis I (GO:0060631)5.50433238
34spermatogenesis (GO:0007283)5.28722137
35male gamete generation (GO:0048232)5.27225815
36L-fucose catabolic process (GO:0042355)5.26600825
37fucose catabolic process (GO:0019317)5.26600825
38L-fucose metabolic process (GO:0042354)5.26600825
39histone H3-K9 modification (GO:0061647)5.02669307
40post-embryonic morphogenesis (GO:0009886)5.02588774
41germ cell development (GO:0007281)5.00557049
42cellular process involved in reproduction in multicellular organism (GO:0022412)4.98567303
43ventricular system development (GO:0021591)4.93316967
44gamete generation (GO:0007276)4.90866692
45negative regulation of inclusion body assembly (GO:0090084)4.77870539
46microtubule severing (GO:0051013)4.77597518
47peptidyl-lysine trimethylation (GO:0018023)4.72675932
48relaxation of smooth muscle (GO:0044557)4.72180940
49regulation of glycoprotein metabolic process (GO:1903018)4.71828166
50histone H3 deacetylation (GO:0070932)4.68498422
51single strand break repair (GO:0000012)4.62117187
52intra-S DNA damage checkpoint (GO:0031573)4.58713955
53positive regulation of vesicle fusion (GO:0031340)4.58151000
54negative regulation of Rho protein signal transduction (GO:0035024)4.57933045
55monoubiquitinated protein deubiquitination (GO:0035520)4.47970400
56mRNA cleavage (GO:0006379)4.47065579
57negative regulation of JNK cascade (GO:0046329)4.46585346
58regulation of gene expression by genetic imprinting (GO:0006349)4.46410602
59meiotic cell cycle process (GO:1903046)4.42907600
60N-terminal protein amino acid acetylation (GO:0006474)4.39846183
61synapsis (GO:0007129)4.23212614
62detection of chemical stimulus involved in sensory perception of smell (GO:0050911)4.22384474
63seminiferous tubule development (GO:0072520)4.19483848
64positive regulation of T cell cytokine production (GO:0002726)4.17698707
65regulation of hydrogen peroxide metabolic process (GO:0010310)4.15231610
66retinal rod cell development (GO:0046548)4.14195790
67DNA synthesis involved in DNA repair (GO:0000731)4.12745080
68protein localization to cilium (GO:0061512)4.11691980
69cell recognition (GO:0008037)4.09818235
70protein polyglutamylation (GO:0018095)4.05505885
71lateral ventricle development (GO:0021670)4.02080480
72genitalia morphogenesis (GO:0035112)4.01920422
73negative regulation of stress-activated MAPK cascade (GO:0032873)3.87793819
74negative regulation of stress-activated protein kinase signaling cascade (GO:0070303)3.87793819
75calcium ion-dependent exocytosis (GO:0017156)3.84631852
76regulation of centriole replication (GO:0046599)3.83784123
77regulation of phosphoprotein phosphatase activity (GO:0043666)3.82739694
78meiotic chromosome segregation (GO:0045132)3.81617107
79multicellular organismal reproductive process (GO:0048609)3.81363289
80negative regulation of organelle assembly (GO:1902116)3.78757972
81regulation of inclusion body assembly (GO:0090083)3.75852910
82nuclear pore complex assembly (GO:0051292)3.74729751
83positive regulation of mRNA 3-end processing (GO:0031442)3.74515872
84regulation of microtubule-based movement (GO:0060632)3.70433800
85coronary vasculature morphogenesis (GO:0060977)3.66673363
86DNA methylation (GO:0006306)3.65063867
87DNA alkylation (GO:0006305)3.65063867
88positive regulation of DNA-templated transcription, initiation (GO:2000144)3.64589620
89centriole assembly (GO:0098534)3.62577048
90organic cation transport (GO:0015695)3.59111139
91mature B cell differentiation (GO:0002335)3.57777053
92gene silencing (GO:0016458)3.57539122
93intraciliary transport (GO:0042073)3.55368724
94potassium ion export (GO:0071435)3.55059276
95fucosylation (GO:0036065)3.53381886
96regulation of ARF GTPase activity (GO:0032312)3.50791623
97regulation of DNA damage checkpoint (GO:2000001)3.44114152
98sister chromatid cohesion (GO:0007062)3.42198835
99pericardium development (GO:0060039)3.41461664
100positive regulation of protein homodimerization activity (GO:0090073)3.35751795
101negative regulation of DNA repair (GO:0045738)3.31818525
102iron-sulfur cluster assembly (GO:0016226)3.30762239
103metallo-sulfur cluster assembly (GO:0031163)3.30762239
1042-deoxyribonucleotide biosynthetic process (GO:0009265)3.28033051
105deoxyribose phosphate biosynthetic process (GO:0046385)3.28033051
106carnitine transmembrane transport (GO:1902603)3.27861416
107pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.22639030
108lymphocyte proliferation (GO:0046651)3.19665094
109amino-acid betaine transport (GO:0015838)3.19379818
110carnitine transport (GO:0015879)3.19379818
111histone lysine demethylation (GO:0070076)3.17092452
112protein demethylation (GO:0006482)3.16332912
113protein dealkylation (GO:0008214)3.16332912
114mononuclear cell proliferation (GO:0032943)3.15343198
115DNA ligation (GO:0006266)3.15276201
116definitive hemopoiesis (GO:0060216)3.15213924
117microtubule-based movement (GO:0007018)3.13902100
118left/right pattern formation (GO:0060972)3.13416285
119embryonic body morphogenesis (GO:0010172)3.12734408
120regulation of DNA-templated transcription, initiation (GO:2000142)3.10393052
121regulation of spindle checkpoint (GO:0090231)3.10091209
122microtubule polymerization or depolymerization (GO:0031109)3.09955309
123spermatid nucleus differentiation (GO:0007289)3.07274863
124regulation of mRNA 3-end processing (GO:0031440)3.07263112
125genetic imprinting (GO:0071514)3.06460701
126histone demethylation (GO:0016577)3.05071962
127nuclear pore organization (GO:0006999)3.04882140
128UMP metabolic process (GO:0046049)3.04330412
129pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.04330412
130UMP biosynthetic process (GO:0006222)3.04330412
131pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.04330412
132multicellular organismal development (GO:0007275)3.01730797
133regulation of immunoglobulin secretion (GO:0051023)3.01465089
134protein K11-linked deubiquitination (GO:0035871)3.01314911
135deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.99608530
136chaperone-mediated protein complex assembly (GO:0051131)2.98465280
137histone exchange (GO:0043486)2.95994628
138regulation of protein polyubiquitination (GO:1902914)2.93571949
139centriole replication (GO:0007099)2.92694412
140cilium morphogenesis (GO:0060271)2.91067687
141cilium organization (GO:0044782)2.90221564
142oogenesis (GO:0048477)2.89218711
143rRNA catabolic process (GO:0016075)2.87464742
144DNA methylation or demethylation (GO:0044728)2.83910841
145cellular response to gamma radiation (GO:0071480)2.81330924
146regulation of chromatin binding (GO:0035561)2.80164746
147regulation of histone H3-K9 methylation (GO:0051570)2.79484460
148pore complex assembly (GO:0046931)2.77177503
149cilium assembly (GO:0042384)2.76074958
150sex differentiation (GO:0007548)2.73030201
151pre-miRNA processing (GO:0031054)2.71714740
152reciprocal meiotic recombination (GO:0007131)2.69470065
153reciprocal DNA recombination (GO:0035825)2.69470065
154protein K6-linked ubiquitination (GO:0085020)2.68160607
155cellular component assembly involved in morphogenesis (GO:0010927)2.67675588
156axoneme assembly (GO:0035082)2.66167133
157mitotic sister chromatid cohesion (GO:0007064)2.65593677
158DNA packaging (GO:0006323)2.65037165
159regulation of protein glycosylation (GO:0060049)14.2377263
160piRNA metabolic process (GO:0034587)13.9346635
161cilium or flagellum-dependent cell motility (GO:0001539)13.9089720
162fusion of sperm to egg plasma membrane (GO:0007342)11.5139671
163male meiosis (GO:0007140)10.8718775
164acrosome assembly (GO:0001675)10.5812463
165axonemal dynein complex assembly (GO:0070286)10.2970357

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.83826245
2E2F7_22180533_ChIP-Seq_HELA_Human5.10448547
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.82504438
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.80710531
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.44105486
6EZH2_22144423_ChIP-Seq_EOC_Human3.82695657
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.27629766
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.94078660
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.77600002
10IGF1R_20145208_ChIP-Seq_DFB_Human2.70282872
11CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.42631502
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.26431352
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.25556422
14ELK4_26923725_Chip-Seq_MESODERM_Mouse2.23548984
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.13773082
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09248245
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.05161770
18KAP1_22055183_ChIP-Seq_ESCs_Mouse2.01873277
19AUTS2_25519132_ChIP-Seq_293T-REX_Human2.01440456
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.8960253
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse10.6728264
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99767562
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.82698220
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.82269170
25P53_22127205_ChIP-Seq_FIBROBLAST_Human1.81785017
26GATA1_26923725_Chip-Seq_HPCs_Mouse1.80355776
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.74977755
28KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.74347271
29ER_23166858_ChIP-Seq_MCF-7_Human1.72738740
30* PRDM14_20953172_ChIP-Seq_ESCs_Human1.63910428
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63603498
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61645919
33VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.60353343
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.58758654
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58016561
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.55809191
37TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.55352094
38AR_20517297_ChIP-Seq_VCAP_Human1.53794450
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.53217965
40P300_19829295_ChIP-Seq_ESCs_Human1.50790017
41STAT1_17558387_ChIP-Seq_HELA_Human1.46991792
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46066803
43GATA3_21867929_ChIP-Seq_CD8_Mouse1.45472512
44RUNX1_26923725_Chip-Seq_HPCs_Mouse1.45428901
45RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43888485
46ZNF274_21170338_ChIP-Seq_K562_Hela1.43476092
47IRF1_19129219_ChIP-ChIP_H3396_Human1.41653168
48* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39636675
49RNF2_27304074_Chip-Seq_NSC_Mouse1.38436477
50GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.38377852
51CRX_20693478_ChIP-Seq_RETINA_Mouse1.33215846
52MYC_18940864_ChIP-ChIP_HL60_Human1.32537240
53FOXA1_21572438_ChIP-Seq_LNCaP_Human1.31875578
54OCT4_18555785_Chip-Seq_ESCs_Mouse1.29377063
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.28455688
56MYC_19829295_ChIP-Seq_ESCs_Human1.27479717
57NANOG_19829295_ChIP-Seq_ESCs_Human1.26796780
58SOX2_19829295_ChIP-Seq_ESCs_Human1.26796780
59* BCAT_22108803_ChIP-Seq_LS180_Human1.25893111
60OCT4_21477851_ChIP-Seq_ESCs_Mouse1.25587957
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24605826
62TAL1_26923725_Chip-Seq_HPCs_Mouse1.24113842
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22727497
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.22387738
65PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19658134
66WDR5_24793694_ChIP-Seq_LNCAP_Human1.19602916
67STAT3_18555785_Chip-Seq_ESCs_Mouse1.19232648
68SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.18633485
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.18583629
70ESRRB_18555785_Chip-Seq_ESCs_Mouse1.18195309
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17911171
72GATA3_21867929_ChIP-Seq_TH1_Mouse1.17640690
73KLF4_18555785_Chip-Seq_ESCs_Mouse1.16916637
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16807214
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.16773224
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15825006
77LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.15787775
78PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15684434
79P300_18555785_Chip-Seq_ESCs_Mouse1.15095498
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14991540
81VDR_22108803_ChIP-Seq_LS180_Human1.14564880
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14040200
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14010568
84PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13887216
85FOXA1_25329375_ChIP-Seq_VCAP_Human1.13508072
86FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13508072
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12858288
88E2F1_20622854_ChIP-Seq_HELA_Human1.12584097
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12233158
90FUS_26573619_Chip-Seq_HEK293_Human1.11693325
91KDM2B_26808549_Chip-Seq_REH_Human1.11201227
92RUNX1_27457419_Chip-Seq_LIVER_Mouse1.10799392
93RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10790692
94* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09113593
95* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09113593
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09089091
97NANOG_20526341_ChIP-Seq_ESCs_Human1.08754387
98GATA3_26560356_Chip-Seq_TH1_Human1.08066097
99BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.07973162
100SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07620912
101EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07264761
102TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.06861954
103NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.06562152
104GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.06138066
105MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05411882
106CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05129710
107SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03927981
108RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03621422
109RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02924772
110IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02680871
111P53_22387025_ChIP-Seq_ESCs_Mouse1.02655666
112BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02241063
113CTCF_18555785_Chip-Seq_ESCs_Mouse1.01862438
114GATA3_21878914_ChIP-Seq_MCF-7_Human1.00822794
115TBL1_22424771_ChIP-Seq_293T_Human1.00767130
116HOXB7_26014856_ChIP-Seq_BT474_Human1.00675941
117SALL1_21062744_ChIP-ChIP_HESCs_Human1.00096793
118GATA3_26560356_Chip-Seq_TH2_Human1.00007548
119CMYC_18555785_Chip-Seq_ESCs_Mouse0.99947890
120STAT3_23295773_ChIP-Seq_U87_Human0.99119811
121OCT1_27270436_Chip-Seq_PROSTATE_Human0.98564849
122SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98342148
123SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97324740
124P300_27268052_Chip-Seq_Bcells_Human0.97067300
125IRF8_27001747_Chip-Seq_BMDM_Mouse0.96250504
126ZFX_18555785_Chip-Seq_ESCs_Mouse0.95895905
127PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95577900
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94762680
129SOX2_22085726_ChIP-Seq_NPCs_Mouse0.94614650
130ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94512408
131SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.94201538
132LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94119399
133* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93992438
134SMAD1_18555785_Chip-Seq_ESCs_Mouse0.93723767
135OCT4_20526341_ChIP-Seq_ESCs_Human0.93624341
136EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93434109
137E2F1_18555785_Chip-Seq_ESCs_Mouse0.93282799
138* TCF4_22108803_ChIP-Seq_LS180_Human0.93247058
139SOX2_18555785_Chip-Seq_ESCs_Mouse0.93239257
140ESET_19884257_ChIP-Seq_ESCs_Mouse0.93191043
141* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93005104
142TP53_18474530_ChIP-ChIP_U2OS_Human0.92508849
143CBP_21632823_ChIP-Seq_H3396_Human0.91699835
144FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91492309
145BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91165324
146GATA6_21074721_ChIP-Seq_CACO-2_Human0.91152520
147KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90926349
148GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90905280
149PU1_27457419_Chip-Seq_LIVER_Mouse0.90109207
150CBP_20019798_ChIP-Seq_JUKART_Human0.90091983
151IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90091983
152CEBPB_22108803_ChIP-Seq_LS180_Human0.90016757
153MYCN_18555785_ChIP-Seq_MESCs_Mouse0.89789505
154RARA_24833708_ChIP-Seq_LIVER_Mouse0.89039658
155* GF1B_26923725_Chip-Seq_HPCs_Mouse0.88467568
156NMYC_18555785_Chip-Seq_ESCs_Mouse0.87689859
157ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87272563
158TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86786924
159MYB_26560356_Chip-Seq_TH2_Human0.86246498
160REST_21632747_ChIP-Seq_MESCs_Mouse0.86049305
161YY1_22570637_ChIP-Seq_MALME-3M_Human0.85296786
162ETV1_20927104_ChIP-Seq_GIST48_Human0.84944418
163TAF2_19829295_ChIP-Seq_ESCs_Human0.84775123
164ERA_21632823_ChIP-Seq_H3396_Human0.84089125
165EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.84059699
166* GF1_26923725_Chip-Seq_HPCs_Mouse0.83932681
167P53_21459846_ChIP-Seq_SAOS-2_Human0.83716438
168* TP63_23658742_ChIP-Seq_EP156T_Human0.82825063
169AHR_22903824_ChIP-Seq_MCF-7_Human0.82161558
170SPI1_26923725_Chip-Seq_HPCs_Mouse0.82019542
171EWS_26573619_Chip-Seq_HEK293_Human0.81115843
172TCF4_23295773_ChIP-Seq_U87_Human0.81102352
173FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81102193
174RBPJ_21746931_ChIP-Seq_IB4_Human0.80455669
175CTCF_27219007_Chip-Seq_Bcells_Human0.80403103
176STAT3_18555785_ChIP-Seq_MESCs_Mouse0.80226513
177GATA3_27048872_Chip-Seq_THYMUS_Human0.77819615
178MYC_27129775_Chip-Seq_CORNEA_Mouse0.77274753
179CDX2_22108803_ChIP-Seq_LS180_Human0.76072372
180FLI1_21867929_ChIP-Seq_CD8_Mouse0.75902479

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.66871370
2MP0004272_abnormal_basement_membrane5.72380435
3MP0001929_abnormal_gametogenesis5.60324665
4MP0003698_abnormal_male_reproductive5.51360153
5MP0002653_abnormal_ependyma_morphology4.36195704
6MP0002210_abnormal_sex_determination4.31080654
7MP0001145_abnormal_male_reproductive3.70658774
8MP0008057_abnormal_DNA_replication3.46851976
9MP0000653_abnormal_sex_gland3.31298260
10MP0002161_abnormal_fertility/fecundity3.04744382
11MP0010094_abnormal_chromosome_stability2.77127335
12MP0008004_abnormal_stomach_pH2.67388483
13MP0008058_abnormal_DNA_repair2.40386391
14MP0005623_abnormal_meninges_morphology2.31492154
15MP0010678_abnormal_skin_adnexa2.27114090
16MP0003315_abnormal_perineum_morphology2.18852671
17MP0009046_muscle_twitch2.14665771
18MP0005360_urolithiasis2.05170666
19MP0005410_abnormal_fertilization12.0024378
20MP0003787_abnormal_imprinting1.91353235
21MP0000678_abnormal_parathyroid_gland1.90348789
22MP0001348_abnormal_lacrimal_gland1.90082194
23MP0008995_early_reproductive_senescence1.85721537
24MP0005409_darkened_coat_color1.85310048
25MP0002138_abnormal_hepatobiliary_system1.71998991
26MP0003646_muscle_fatigue1.70190222
27MP0001501_abnormal_sleep_pattern1.65471101
28MP0003786_premature_aging1.64219332
29MP0002160_abnormal_reproductive_system1.64191897
30MP0001835_abnormal_antigen_presentation1.63786988
31MP0000371_diluted_coat_color1.63329591
32MP0005379_endocrine/exocrine_gland_phen1.50978304
33MP0008789_abnormal_olfactory_epithelium1.47416904
34MP0001790_abnormal_immune_system1.45085654
35MP0005387_immune_system_phenotype1.45085654
36MP0008007_abnormal_cellular_replicative1.41140943
37MP0003111_abnormal_nucleus_morphology1.34861515
38MP0001661_extended_life_span1.32781735
39MP0002452_abnormal_antigen_presenting1.31078812
40MP0005394_taste/olfaction_phenotype1.29440246
41MP0005499_abnormal_olfactory_system1.29440246
42MP0005248_abnormal_Harderian_gland1.25115696
43MP0001800_abnormal_humoral_immune1.21511527
44MP0002723_abnormal_immune_serum1.20090955
45MP0000015_abnormal_ear_pigmentation1.19918467
46MP0005647_abnormal_sex_gland1.16434737
47MP0001819_abnormal_immune_cell1.13837769
48MP0004808_abnormal_hematopoietic_stem1.12249426
49MP0005167_abnormal_blood-brain_barrier1.12138132
50MP0002420_abnormal_adaptive_immunity1.11106751
51MP0002132_abnormal_respiratory_system1.10773618
52MP0010307_abnormal_tumor_latency1.09507579
53MP0004782_abnormal_surfactant_physiolog1.08684825
54MP0003077_abnormal_cell_cycle1.07977778
55MP0000465_gastrointestinal_hemorrhage1.07687122
56MP0002282_abnormal_trachea_morphology1.06961624
57MP0002102_abnormal_ear_morphology1.04805607
58MP0003183_abnormal_peptide_metabolism1.01377155
59MP0001119_abnormal_female_reproductive1.00857554
60MP0000716_abnormal_immune_system0.98310646
61MP0005174_abnormal_tail_pigmentation0.95596218
62MP0001188_hyperpigmentation0.94790155
63MP0003699_abnormal_female_reproductive0.93284492
64MP0002398_abnormal_bone_marrow0.91887725
65MP0005551_abnormal_eye_electrophysiolog0.91285400
66MP0003879_abnormal_hair_cell0.89328491
67MP0002127_abnormal_cardiovascular_syste0.88862379
68MP0000358_abnormal_cell_content/0.88454222
69MP0005389_reproductive_system_phenotype0.87067440
70MP0005670_abnormal_white_adipose0.84969104
71MP0000427_abnormal_hair_cycle0.84062945
72MP0003890_abnormal_embryonic-extraembry0.82333941
73MP0002249_abnormal_larynx_morphology0.82277032
74MP0001730_embryonic_growth_arrest0.82071455
75MP0003011_delayed_dark_adaptation0.81092841
76MP0001984_abnormal_olfaction0.80622537
77MP0009785_altered_susceptibility_to0.78808190
78MP0001664_abnormal_digestion0.76106744
79MP0000685_abnormal_immune_system0.75566923
80MP0002429_abnormal_blood_cell0.73373982
81MP0002148_abnormal_hypersensitivity_rea0.73256695
82MP0005000_abnormal_immune_tolerance0.73245791
83MP0009840_abnormal_foam_cell0.73033944
84MP0003718_maternal_effect0.71622572
85MP0002734_abnormal_mechanical_nocicepti0.71181877
86MP0001485_abnormal_pinna_reflex0.71010628
87MP0004233_abnormal_muscle_weight0.70861489
88MP0009697_abnormal_copulation0.70472310
89MP0000703_abnormal_thymus_morphology0.69968046
90MP0001486_abnormal_startle_reflex0.68597269
91MP0000647_abnormal_sebaceous_gland0.68279861
92MP0005058_abnormal_lysosome_morphology0.67194009
93MP0001293_anophthalmia0.66073463
94MP0002269_muscular_atrophy0.66063801
95MP0005645_abnormal_hypothalamus_physiol0.64684786
96MP0005380_embryogenesis_phenotype0.64635431
97MP0001672_abnormal_embryogenesis/_devel0.64635431
98MP0008875_abnormal_xenobiotic_pharmacok0.63824581
99MP0001191_abnormal_skin_condition0.63067408
100MP0005671_abnormal_response_to0.62866469
101MP0002084_abnormal_developmental_patter0.61341851
102MP0001697_abnormal_embryo_size0.59242658
103MP0000313_abnormal_cell_death0.58219805
104MP0009745_abnormal_behavioral_response0.57800330
105MP0004134_abnormal_chest_morphology0.57500634
106MP0005646_abnormal_pituitary_gland0.57430966
107MP0001919_abnormal_reproductive_system0.57049589
108MP0003763_abnormal_thymus_physiology0.56978495
109MP0003950_abnormal_plasma_membrane0.55527171
110MP0003693_abnormal_embryo_hatching0.55023007
111MP0003984_embryonic_growth_retardation0.54371863
112MP0004742_abnormal_vestibular_system0.54250463
113MP0005584_abnormal_enzyme/coenzyme_acti0.54063289
114MP0000230_abnormal_systemic_arterial0.53855294
115MP0003724_increased_susceptibility_to0.53649223
116MP0001186_pigmentation_phenotype0.53400129
117MP0004957_abnormal_blastocyst_morpholog0.52856780
118MP0002085_abnormal_embryonic_tissue0.51591871
119MP0002088_abnormal_embryonic_growth/wei0.50847594
120MP0005377_hearing/vestibular/ear_phenot0.50583434
121MP0003878_abnormal_ear_physiology0.50583434
122MP0003936_abnormal_reproductive_system0.50161543
123MP0003861_abnormal_nervous_system0.49744302
124MP0004130_abnormal_muscle_cell0.48909896
125MP0001765_abnormal_ion_homeostasis0.48686316
126MP0001727_abnormal_embryo_implantation0.46606212
127MP0002971_abnormal_brown_adipose0.44428580
128MP0000350_abnormal_cell_proliferation0.42247644
129MP0003632_abnormal_nervous_system0.41419069
130MP0003115_abnormal_respiratory_system0.38607557
131MP0005397_hematopoietic_system_phenotyp0.38256813
132MP0001545_abnormal_hematopoietic_system0.38256813
133MP0009703_decreased_birth_body0.37192848
134MP0002233_abnormal_nose_morphology0.36591908
135MP0008961_abnormal_basal_metabolism0.36032070
136MP0000428_abnormal_craniofacial_morphol0.36025538
137MP0000747_muscle_weakness0.35271462
138MP0003045_fibrosis0.34481161
139MP0002152_abnormal_brain_morphology0.34350926
140MP0002080_prenatal_lethality0.34161975
141MP0004043_abnormal_pH_regulation0.32962456
142MP0004197_abnormal_fetal_growth/weight/0.32907691
143MP0000432_abnormal_head_morphology0.32310655
144MP0005391_vision/eye_phenotype0.32006572
145MP0006292_abnormal_olfactory_placode0.31693965
146MP0000569_abnormal_digit_pigmentation0.31294590
147MP0005395_other_phenotype0.29905480
148MP0008932_abnormal_embryonic_tissue0.29894186
149MP0002086_abnormal_extraembryonic_tissu0.29792380
150MP0009115_abnormal_fat_cell0.29721141
151MP0002092_abnormal_eye_morphology0.29639124
152MP0002019_abnormal_tumor_incidence0.28904275
153MP0004036_abnormal_muscle_relaxation0.28297977
154MP0002114_abnormal_axial_skeleton0.27818358
155MP0009278_abnormal_bone_marrow0.27472384
156MP0009672_abnormal_birth_weight0.27079864
157MP0006035_abnormal_mitochondrial_morpho0.27069162
158MP0000631_abnormal_neuroendocrine_gland0.26424973
159MP0005253_abnormal_eye_physiology0.25140593
160MP0001216_abnormal_epidermal_layer0.25014203
161MP0000383_abnormal_hair_follicle0.24211013
162MP0005451_abnormal_body_composition0.23746494
163MP0002928_abnormal_bile_duct0.23227601

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.07548137
2Rhinitis (HP:0012384)7.77523437
3Abnormal respiratory epithelium morphology (HP:0012253)7.74045305
4Abnormal respiratory motile cilium morphology (HP:0005938)7.74045305
5Abnormal ciliary motility (HP:0012262)7.27715006
6Chronic bronchitis (HP:0004469)6.95384427
7Gastrointestinal stroma tumor (HP:0100723)6.66542088
8Nasal polyposis (HP:0100582)5.93174671
9Spinal rigidity (HP:0003306)5.73577924
10Infertility (HP:0000789)5.23036142
11Abnormality of the calf musculature (HP:0001430)4.96443214
12Abnormality of the nasal mucosa (HP:0000433)4.81215596
13Transposition of the great arteries (HP:0001669)4.65358016
14Abnormal connection of the cardiac segments (HP:0011545)4.65358016
15Abnormal ventriculo-arterial connection (HP:0011563)4.65358016
16Abnormality of DNA repair (HP:0003254)4.52589362
17Nephronophthisis (HP:0000090)4.24398606
18Bronchiectasis (HP:0002110)4.22666166
19Lissencephaly (HP:0001339)4.19914727
20Hypoplasia of the brainstem (HP:0002365)4.00711067
21Aplasia/Hypoplasia of the brainstem (HP:0007362)4.00711067
22Bronchitis (HP:0012387)4.00288075
23Abnormality of the vitreous humor (HP:0004327)3.97631725
24Meningocele (HP:0002435)3.92432115
25Muscular dystrophy (HP:0003560)3.89079008
26Abnormality of the lower motor neuron (HP:0002366)3.76892634
27Renovascular hypertension (HP:0100817)3.76609478
28Poikiloderma (HP:0001029)3.71791416
29Vasculitis (HP:0002633)3.68248672
30Entropion (HP:0000621)3.63600484
31Sensory axonal neuropathy (HP:0003390)3.52514834
32Lymphopenia (HP:0001888)3.49019690
33Overriding aorta (HP:0002623)3.46428902
34Elfin facies (HP:0004428)3.43940399
35Hyperacusis (HP:0010780)3.42589359
36Facial hemangioma (HP:0000329)3.42476625
37Emphysema (HP:0002097)3.37023915
38Non-midline cleft lip (HP:0100335)3.35747180
39Metaphyseal dysplasia (HP:0100255)3.28669432
40Lip pit (HP:0100267)3.24964148
41Gowers sign (HP:0003391)3.16081292
42Abnormality of the renal medulla (HP:0100957)3.14933379
43Toxemia of pregnancy (HP:0100603)3.12055275
44Male infertility (HP:0003251)3.11802002
45Abnormal spermatogenesis (HP:0008669)3.10223806
46Restrictive lung disease (HP:0002091)3.05364994
47Recurrent otitis media (HP:0000403)3.03520973
48Pachygyria (HP:0001302)3.03339428
49Abnormality of cells of the lymphoid lineage (HP:0012140)2.97776586
50Gonadotropin excess (HP:0000837)2.91004952
51Tubular atrophy (HP:0000092)2.88460485
52Amelogenesis imperfecta (HP:0000705)2.86286576
53Azoospermia (HP:0000027)2.86238287
54Renal duplication (HP:0000075)2.85342616
55Flat cornea (HP:0007720)2.84937024
56Recurrent sinusitis (HP:0011108)2.82020537
57Insomnia (HP:0100785)2.80086774
58Amyotrophic lateral sclerosis (HP:0007354)2.69973287
59Molar tooth sign on MRI (HP:0002419)2.62048053
60Abnormality of midbrain morphology (HP:0002418)2.62048053
61Fibular hypoplasia (HP:0003038)2.61270501
62Pulmonic stenosis (HP:0001642)2.56846611
63Capillary hemangiomas (HP:0005306)2.54564591
64Microglossia (HP:0000171)2.51822236
65Leukopenia (HP:0001882)2.45584600
66Hyporeflexia of lower limbs (HP:0002600)2.38475444
67Concave nail (HP:0001598)2.31922688
68Abnormality of dental color (HP:0011073)2.31253657
69Medial flaring of the eyebrow (HP:0010747)2.29583947
70Chronic sinusitis (HP:0011109)2.28859934
71Inflammation of the large intestine (HP:0002037)2.23663366
72Tubulointerstitial nephritis (HP:0001970)2.23429325
73Holoprosencephaly (HP:0001360)2.21596299
74Abnormality of the diencephalon (HP:0010662)2.21175561
75Polymicrogyria (HP:0002126)2.20609504
76Dandy-Walker malformation (HP:0001305)2.19910097
77Increased nuchal translucency (HP:0010880)2.19834927
78Postaxial foot polydactyly (HP:0001830)2.19515482
79Polygenic inheritance (HP:0010982)2.16689456
80Porencephaly (HP:0002132)2.14392605
8111 pairs of ribs (HP:0000878)2.14193507
82Upper motor neuron abnormality (HP:0002127)2.12291823
83Retrobulbar optic neuritis (HP:0100654)2.09163450
84Optic neuritis (HP:0100653)2.09163450
85Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.08955571
86Gastrointestinal inflammation (HP:0004386)2.08550423
873-Methylglutaconic aciduria (HP:0003535)2.08422324
88Recurrent bronchitis (HP:0002837)2.03557174
89Keratitis (HP:0000491)2.00991341
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1979566
91Type II lissencephaly (HP:0007260)12.6978926
92Calf muscle hypertrophy (HP:0008981)11.8979669
93Dynein arm defect of respiratory motile cilia (HP:0012255)10.7095323
94Absent/shortened dynein arms (HP:0200106)10.7095323
95Muscle hypertrophy of the lower extremities (HP:0008968)10.5534989
96Retinal dysplasia (HP:0007973)10.1970236
97Impulsivity (HP:0100710)1.99311335
98Abnormality of the carotid arteries (HP:0005344)1.99107421
99Tubulointerstitial abnormality (HP:0001969)1.95314388
100Ectropion (HP:0000656)1.94853608
101Impaired proprioception (HP:0010831)1.94154096
102Megalocornea (HP:0000485)1.92287063
103Stage 5 chronic kidney disease (HP:0003774)1.89280527
104Cerebellar dysplasia (HP:0007033)1.89235438
105Colitis (HP:0002583)1.88885019
106Oculomotor apraxia (HP:0000657)1.87708726
107Degeneration of anterior horn cells (HP:0002398)1.87224626
108Abnormality of the anterior horn cell (HP:0006802)1.87224626
109Posterior subcapsular cataract (HP:0007787)1.86397854
110Epiphyseal dysplasia (HP:0002656)1.82744543
111Congenital hepatic fibrosis (HP:0002612)1.79277532
112Abnormality of the renal cortex (HP:0011035)1.78309091
113Short ribs (HP:0000773)1.75724703
114Median cleft lip (HP:0000161)1.75693144
115Bladder diverticulum (HP:0000015)1.74624787
116Aplasia/Hypoplasia of the fibula (HP:0006492)1.74380694
117Retinal detachment (HP:0000541)1.74056411
118Heterotopia (HP:0002282)1.73915489
119Supernumerary spleens (HP:0009799)1.71523832
120Prolonged neonatal jaundice (HP:0006579)1.70404343
121Aplasia/Hypoplasia of the tongue (HP:0010295)1.70056319
122Aplasia/Hypoplasia of the uvula (HP:0010293)1.70029850
123Ectopic kidney (HP:0000086)1.69140877
124Renal dysplasia (HP:0000110)1.68753641
125Facial cleft (HP:0002006)1.67414811
126Absent frontal sinuses (HP:0002688)1.66387368
127Orchitis (HP:0100796)1.64835407
128Selective tooth agenesis (HP:0001592)1.64090812
129Small intestinal stenosis (HP:0012848)1.63403205
130Duodenal stenosis (HP:0100867)1.63403205
131Abnormality of chromosome stability (HP:0003220)1.62513567
132Hypoplasia of the capital femoral epiphysis (HP:0003090)1.62269173
133Pancreatic fibrosis (HP:0100732)1.61806753
134Bowel diverticulosis (HP:0005222)1.60620205
135Agammaglobulinemia (HP:0004432)1.59742884
136Large eyes (HP:0001090)1.58475582
137Curly hair (HP:0002212)1.57504911
138Tubulointerstitial fibrosis (HP:0005576)1.57427260
139Postaxial hand polydactyly (HP:0001162)1.57004380
140Hypoplasia of the uterus (HP:0000013)1.56367373
141Abnormal drinking behavior (HP:0030082)1.55499423
142Polydipsia (HP:0001959)1.55499423
143Abnormality of chromosome segregation (HP:0002916)1.54998321
144Oligodactyly (hands) (HP:0001180)1.51794366
145Abnormality of the columella (HP:0009929)1.50904947
146Hyperglycinuria (HP:0003108)1.49786594
147Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.49150342
148Breast carcinoma (HP:0003002)1.48136789
149Pancreatic cysts (HP:0001737)1.47768024
150Abnormality of ocular smooth pursuit (HP:0000617)1.47618949
151Myositis (HP:0100614)1.46587296
152Sex reversal (HP:0012245)1.46255024
153Abnormal sex determination (HP:0012244)1.46255024
154Clubbing of toes (HP:0100760)1.46253867
155Spontaneous abortion (HP:0005268)1.45593276
156Polycystic kidney dysplasia (HP:0000113)1.43757094
157Congenital stationary night blindness (HP:0007642)1.43495750
158J-shaped sella turcica (HP:0002680)1.41292225
159Abnormal delayed hypersensitivity skin test (HP:0002963)1.41048916
160Keratoconjunctivitis sicca (HP:0001097)1.41003573
161Resting tremor (HP:0002322)1.40982148
162Short thorax (HP:0010306)1.39560800
163Male pseudohermaphroditism (HP:0000037)1.37371790
164Morphological abnormality of the pyramidal tract (HP:0002062)1.36962343
165Sloping forehead (HP:0000340)1.35289079
166Meckel diverticulum (HP:0002245)1.34869099
167Poikilocytosis (HP:0004447)1.34781789
168Gait imbalance (HP:0002141)1.34659594
169Congenital primary aphakia (HP:0007707)1.34091642
170Spastic tetraparesis (HP:0001285)1.33956006
171Cystic liver disease (HP:0006706)1.33898618
172Tongue fasciculations (HP:0001308)1.33689765
173Chromosomal breakage induced by crosslinking agents (HP:0003221)1.32698725
174Areflexia of lower limbs (HP:0002522)1.31869781
175Abnormality of the lumbar spine (HP:0100712)1.31359727
176Abnormality of the ileum (HP:0001549)1.31288572
177Abnormality of molar morphology (HP:0011070)1.30928715
178Abnormality of molar (HP:0011077)1.30928715
179Retinal atrophy (HP:0001105)1.30661245
180Optic nerve hypoplasia (HP:0000609)1.30114965
181Lymphoma (HP:0002665)1.28854014
182Cerebellar hypoplasia (HP:0001321)1.28680844

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.06361913
2PDK49.06361913
3PDK25.79287072
4ARAF2.89266589
5PRKD32.83394179
6TESK12.73083039
7MAP3K132.64041843
8MARK32.49932576
9STK392.23748774
10MAP3K102.21120051
11WNK42.20701208
12PTK2B2.15004268
13NEK22.08981111
14CDK1912.9677290
15ICK1.97406276
16SIK31.81911744
17CDC71.80058892
18PNCK1.77667415
19TEC1.70713470
20MAP3K91.69780603
21STK31.51359651
22TTK1.32598678
23TRIM281.32475349
24STK381.28291466
25WEE11.26853345
26BTK1.18547730
27BRD41.10382737
28TYRO31.08469911
29YES11.07263798
30CDK121.06620689
31WNK11.05344132
32MAPK151.03274405
33ITK1.02792622
34ADRBK21.02763973
35STK38L1.02685304
36CHEK21.01809405
37PLK41.01025319
38MOS1.00614981
39RIPK40.97556573
40MAP2K60.94202067
41CCNB10.94007674
42PDGFRB0.93110231
43KSR20.90082914
44KSR10.88623534
45BMPR1B0.86605815
46ATR0.85442841
47MAPK110.84735390
48CDK30.84136799
49CHEK10.84044889
50RPS6KA50.83164291
51IRAK40.81856333
52MINK10.78018932
53SYK0.76246047
54PLK10.75564657
55TLK10.72728593
56LATS10.71952732
57BRSK20.71887321
58GRK10.71856045
59INSRR0.71592768
60MAP4K10.68522960
61PDK10.67160482
62PASK0.66829340
63PRKCZ0.65798789
64PLK20.65008332
65TAOK10.62431659
66MAP3K20.61750196
67DYRK30.60903557
68BMPR20.57005919
69ATM0.55703470
70MAP3K40.55042759
71MAP2K70.53849172
72EIF2AK20.52575174
73PRKCQ0.52493166
74MTOR0.51438858
75TIE10.51182602
76CDK11A0.50997011
77MATK0.49731946
78PINK10.49026048
79LATS20.47580121
80LMTK20.45739741
81CAMK2D0.45663927
82CSF1R0.45315795
83MYLK0.43905662
84RPS6KA40.42662186
85CDK70.41823346
86OXSR10.41770359
87MET0.41333221
88SRPK10.39863366
89PRKCB0.38817263
90ACVR1B0.38736024
91GRK60.38431423
92MAP3K70.37926014
93BRAF0.37919454
94TYK20.37705985
95FRK0.36610616
96MST1R0.36115179
97RAF10.35920624
98FGR0.34905398
99NTRK20.34271223
100MAP3K10.33768362
101FES0.32844070
102ZAP700.32506018
103AKT30.32212237
104SIK20.30556395
105NEK60.29499952
106WNK30.29390858
107DYRK1B0.29102600
108OBSCN0.29059408
109AURKB0.28968769
110NME10.27637723
111CDK140.27120159
112CDK10.27074522
113PRKAA10.26540222
114LYN0.25897543
115MAP3K60.25802553
116IKBKB0.25763235
117STK40.25570322
118BUB10.25033305
119TAOK30.24032654
120NEK90.23898577
121ZAK0.23873609
122NTRK30.23479511
123MAPK100.23056014
124CDK20.21758199
125BRSK10.20499014
126RPS6KA30.20474957
127MAPK30.20144677
128STK100.20044833
129CSNK1E0.18990413
130IRAK20.18976759
131EGFR0.18438863
132CSNK2A20.18002717
133MARK20.16840414
134CDK40.16758242
135ERBB30.16703688
136PAK10.16041658
137CAMK2B0.15818138
138HCK0.13633777
139ABL10.13621916
140STK110.12991593
141PRKG10.11972970
142AURKA0.11778855
143TESK20.11713630
144CSNK1D0.11083222
145CAMK1G0.10815967
146GSK3B0.09961962
147EEF2K0.09117127
148RPS6KB10.08898406
149PRKDC0.08870147
150CDK90.07901106
151PDPK10.07604852
152MAPK80.07020003
153IRAK10.06796831
154STK160.06629713
155MAPK70.05935601
156PAK60.05164156
157PRKACB0.04900505
158CAMKK10.04162629
159INSR0.03787208
160PRKD20.03783120
161MAPK10.03365398
162PRKCG0.03005277
163ERBB40.01560479
164CSNK2A10.01132368
165VRK10.00724543
166PAK20.00231669

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.39215714
2Olfactory transduction_Homo sapiens_hsa047404.17124774
3Basal transcription factors_Homo sapiens_hsa030223.99356637
4Fanconi anemia pathway_Homo sapiens_hsa034603.91082424
5Dorso-ventral axis formation_Homo sapiens_hsa043203.55513093
6Pyruvate metabolism_Homo sapiens_hsa006203.52103270
7Asthma_Homo sapiens_hsa053103.48805144
8Homologous recombination_Homo sapiens_hsa034403.39995603
9Intestinal immune network for IgA production_Homo sapiens_hsa046723.18765560
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.11621934
11Hematopoietic cell lineage_Homo sapiens_hsa046403.08916809
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.97445166
13Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.92007204
14Allograft rejection_Homo sapiens_hsa053302.81990585
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.74349097
16Selenocompound metabolism_Homo sapiens_hsa004502.74283366
17Autoimmune thyroid disease_Homo sapiens_hsa053202.71454641
18Graft-versus-host disease_Homo sapiens_hsa053322.62460761
19Linoleic acid metabolism_Homo sapiens_hsa005912.59329058
20Propanoate metabolism_Homo sapiens_hsa006402.51872467
21Glucagon signaling pathway_Homo sapiens_hsa049222.33689784
22Oocyte meiosis_Homo sapiens_hsa041142.26433925
23Cysteine and methionine metabolism_Homo sapiens_hsa002702.20929415
24Fatty acid biosynthesis_Homo sapiens_hsa000612.12509070
25Type I diabetes mellitus_Homo sapiens_hsa049402.11903932
26RNA transport_Homo sapiens_hsa030132.07151125
27Glycerolipid metabolism_Homo sapiens_hsa005611.91143215
28Phagosome_Homo sapiens_hsa041451.89428267
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85560395
30Gap junction_Homo sapiens_hsa045401.75532152
31mRNA surveillance pathway_Homo sapiens_hsa030151.72511136
32Primary immunodeficiency_Homo sapiens_hsa053401.68774535
33Staphylococcus aureus infection_Homo sapiens_hsa051501.64949711
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.64938633
35Notch signaling pathway_Homo sapiens_hsa043301.62926400
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.61258894
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.54151830
38Huntingtons disease_Homo sapiens_hsa050161.53705152
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.50187918
40Cell cycle_Homo sapiens_hsa041101.49736443
41* Pentose phosphate pathway_Homo sapiens_hsa000301.48738134
42Ether lipid metabolism_Homo sapiens_hsa005651.43954340
43Glycerophospholipid metabolism_Homo sapiens_hsa005641.43671537
44B cell receptor signaling pathway_Homo sapiens_hsa046621.43265869
45Leishmaniasis_Homo sapiens_hsa051401.30475318
46Nitrogen metabolism_Homo sapiens_hsa009101.23315446
47Systemic lupus erythematosus_Homo sapiens_hsa053221.18913266
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17912195
49Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13974236
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.08794431
51PPAR signaling pathway_Homo sapiens_hsa033201.06368111
52Viral myocarditis_Homo sapiens_hsa054161.04644011
53NF-kappa B signaling pathway_Homo sapiens_hsa040641.04161797
54RNA degradation_Homo sapiens_hsa030181.02238561
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01688228
56Influenza A_Homo sapiens_hsa051641.00634717
57Amphetamine addiction_Homo sapiens_hsa050311.00276660
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99088809
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98786645
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97515974
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97451052
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96649539
63Lysine degradation_Homo sapiens_hsa003100.96318137
64Rheumatoid arthritis_Homo sapiens_hsa053230.94624122
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94326744
66Toxoplasmosis_Homo sapiens_hsa051450.93720360
67Phototransduction_Homo sapiens_hsa047440.93054804
68Purine metabolism_Homo sapiens_hsa002300.88253030
69Fat digestion and absorption_Homo sapiens_hsa049750.82569319
70Renin secretion_Homo sapiens_hsa049240.81444283
71Apoptosis_Homo sapiens_hsa042100.79507022
72p53 signaling pathway_Homo sapiens_hsa041150.78735208
73Antigen processing and presentation_Homo sapiens_hsa046120.78033906
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77549070
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76698231
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75916500
77Nicotine addiction_Homo sapiens_hsa050330.72538668
78Fructose and mannose metabolism_Homo sapiens_hsa000510.70914410
79Regulation of autophagy_Homo sapiens_hsa041400.68818274
80* Carbon metabolism_Homo sapiens_hsa012000.66954115
81ABC transporters_Homo sapiens_hsa020100.66379675
82Renin-angiotensin system_Homo sapiens_hsa046140.60325615
83Inositol phosphate metabolism_Homo sapiens_hsa005620.60265080
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.60148136
85Arachidonic acid metabolism_Homo sapiens_hsa005900.59273144
86Viral carcinogenesis_Homo sapiens_hsa052030.58971373
87MAPK signaling pathway_Homo sapiens_hsa040100.58448549
88Fatty acid metabolism_Homo sapiens_hsa012120.56539106
89Osteoclast differentiation_Homo sapiens_hsa043800.55693051
90Base excision repair_Homo sapiens_hsa034100.55032855
91Gastric acid secretion_Homo sapiens_hsa049710.53678985
92N-Glycan biosynthesis_Homo sapiens_hsa005100.52401842
93Nucleotide excision repair_Homo sapiens_hsa034200.51815284
94Mismatch repair_Homo sapiens_hsa034300.50437145
95Estrogen signaling pathway_Homo sapiens_hsa049150.49757966
96Tuberculosis_Homo sapiens_hsa051520.49630090
97Taste transduction_Homo sapiens_hsa047420.49276315
98Long-term potentiation_Homo sapiens_hsa047200.48755324
99Non-homologous end-joining_Homo sapiens_hsa034500.48558745
100VEGF signaling pathway_Homo sapiens_hsa043700.48185749
101* Biosynthesis of amino acids_Homo sapiens_hsa012300.47354618
102Cardiac muscle contraction_Homo sapiens_hsa042600.47349229
103AMPK signaling pathway_Homo sapiens_hsa041520.47231543
104Epstein-Barr virus infection_Homo sapiens_hsa051690.46534635
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44923021
106Endocytosis_Homo sapiens_hsa041440.44841563
107Arginine biosynthesis_Homo sapiens_hsa002200.43981607
108Fatty acid degradation_Homo sapiens_hsa000710.43784474
109Ovarian steroidogenesis_Homo sapiens_hsa049130.43218232
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42810446
111Protein digestion and absorption_Homo sapiens_hsa049740.42755356
112Alcoholism_Homo sapiens_hsa050340.42739282
113Pertussis_Homo sapiens_hsa051330.42253504
114GABAergic synapse_Homo sapiens_hsa047270.40823239
115Mineral absorption_Homo sapiens_hsa049780.40676414
116Choline metabolism in cancer_Homo sapiens_hsa052310.40370349
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40102059
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39323401
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39172943
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37208632
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.36855310
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36851838
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34969065
124Hedgehog signaling pathway_Homo sapiens_hsa043400.31976796
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31361337
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30089726
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29524003
128Sphingolipid metabolism_Homo sapiens_hsa006000.29452862
129HTLV-I infection_Homo sapiens_hsa051660.28977605
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28484288
131Steroid biosynthesis_Homo sapiens_hsa001000.28269321
132* Metabolic pathways_Homo sapiens_hsa011000.27836034
133Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26792470
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26517029
135Pyrimidine metabolism_Homo sapiens_hsa002400.25330844
136RNA polymerase_Homo sapiens_hsa030200.25044904
137Retinol metabolism_Homo sapiens_hsa008300.24812928
138Glutathione metabolism_Homo sapiens_hsa004800.24785479
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24615983
140T cell receptor signaling pathway_Homo sapiens_hsa046600.24119260
141Morphine addiction_Homo sapiens_hsa050320.22791676
142Jak-STAT signaling pathway_Homo sapiens_hsa046300.22506158
143Legionellosis_Homo sapiens_hsa051340.21286915
144Butanoate metabolism_Homo sapiens_hsa006500.21001124
145DNA replication_Homo sapiens_hsa030300.20943956
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.20539166
147Wnt signaling pathway_Homo sapiens_hsa043100.20150156
148Salivary secretion_Homo sapiens_hsa049700.20066553
149Calcium signaling pathway_Homo sapiens_hsa040200.18593578
150ErbB signaling pathway_Homo sapiens_hsa040120.18440831
151Caffeine metabolism_Homo sapiens_hsa002320.18412758
152Herpes simplex infection_Homo sapiens_hsa051680.18308637
153Hepatitis B_Homo sapiens_hsa051610.18211577
154Chemical carcinogenesis_Homo sapiens_hsa052040.18123649
155Spliceosome_Homo sapiens_hsa030400.18012967
156Vascular smooth muscle contraction_Homo sapiens_hsa042700.17172596
157Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17118990
158Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16540036
159Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15893454
160Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.14753025

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