TLCD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alpha-linolenic acid metabolic process (GO:0036109)5.84980832
2glycine metabolic process (GO:0006544)5.51850782
3regulation of protein activation cascade (GO:2000257)5.45916811
4complement activation, alternative pathway (GO:0006957)5.40012070
5L-phenylalanine metabolic process (GO:0006558)5.35806826
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.35806826
7regulation of complement activation (GO:0030449)5.28279936
8protein carboxylation (GO:0018214)5.28106905
9peptidyl-glutamic acid carboxylation (GO:0017187)5.28106905
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.18942789
11L-phenylalanine catabolic process (GO:0006559)5.08981603
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.08981603
13serine family amino acid catabolic process (GO:0009071)4.94287235
14DNA replication checkpoint (GO:0000076)4.90287303
15DNA replication-dependent nucleosome assembly (GO:0006335)4.86460493
16DNA replication-dependent nucleosome organization (GO:0034723)4.86460493
17ribosomal small subunit biogenesis (GO:0042274)4.85610033
18rRNA modification (GO:0000154)4.85049345
19negative regulation of fibrinolysis (GO:0051918)4.81446069
20urea metabolic process (GO:0019627)4.76905466
21urea cycle (GO:0000050)4.76905466
22bile acid biosynthetic process (GO:0006699)4.68857913
23amino-acid betaine metabolic process (GO:0006577)4.64344614
24GDP-mannose metabolic process (GO:0019673)4.64013692
25rRNA methylation (GO:0031167)4.63885455
26regulation of fibrinolysis (GO:0051917)4.63655614
27serine family amino acid metabolic process (GO:0009069)4.62770779
28serine family amino acid biosynthetic process (GO:0009070)4.62264889
29aromatic amino acid family catabolic process (GO:0009074)4.57740662
30ethanol oxidation (GO:0006069)4.52923998
31regulation of bile acid biosynthetic process (GO:0070857)4.35658950
32nitrogen cycle metabolic process (GO:0071941)4.33194713
33L-serine metabolic process (GO:0006563)4.30581687
34homocysteine metabolic process (GO:0050667)4.30005547
35pseudouridine synthesis (GO:0001522)4.25619659
36cellular glucuronidation (GO:0052695)4.25060395
37cysteine metabolic process (GO:0006534)4.21905626
38sulfur amino acid catabolic process (GO:0000098)4.20100907
39response to nitrosative stress (GO:0051409)4.06338383
40bile acid metabolic process (GO:0008206)4.00514062
41tryptophan catabolic process (GO:0006569)3.96258587
42indole-containing compound catabolic process (GO:0042436)3.96258587
43indolalkylamine catabolic process (GO:0046218)3.96258587
44positive regulation of fatty acid beta-oxidation (GO:0032000)3.87622968
45fibrinolysis (GO:0042730)3.86570523
46regulation of mitochondrial translation (GO:0070129)3.86327049
47proteasome assembly (GO:0043248)3.81747739
48DNA strand renaturation (GO:0000733)3.81278699
49blood coagulation, intrinsic pathway (GO:0007597)3.74596371
50kynurenine metabolic process (GO:0070189)3.73296048
51tryptophan metabolic process (GO:0006568)3.70799828
52glyoxylate metabolic process (GO:0046487)3.70269118
53glucuronate metabolic process (GO:0019585)3.69598048
54uronic acid metabolic process (GO:0006063)3.69598048
55triglyceride homeostasis (GO:0070328)3.69464008
56acylglycerol homeostasis (GO:0055090)3.69464008
57ribonucleoprotein complex biogenesis (GO:0022613)3.65343164
58alpha-amino acid catabolic process (GO:1901606)3.63766158
59mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.62489837
60glutamate metabolic process (GO:0006536)3.60159896
61regulation of cholesterol esterification (GO:0010872)3.57308656
62cytolysis (GO:0019835)3.56562224
63dicarboxylic acid biosynthetic process (GO:0043650)3.56467189
64transcription elongation from RNA polymerase III promoter (GO:0006385)3.56084872
65termination of RNA polymerase III transcription (GO:0006386)3.56084872
66regulation of triglyceride catabolic process (GO:0010896)3.56031264
67negative regulation of viral transcription (GO:0032897)3.55941779
68carnitine metabolic process (GO:0009437)3.52589095
69complement activation, classical pathway (GO:0006958)3.52446166
70antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.49548789
71antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.49548789
72protein-lipid complex remodeling (GO:0034368)3.49309999
73macromolecular complex remodeling (GO:0034367)3.49309999
74plasma lipoprotein particle remodeling (GO:0034369)3.49309999
75folic acid-containing compound biosynthetic process (GO:0009396)3.48610112
76negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.46318789
77fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.43490702
78ribosome biogenesis (GO:0042254)3.43365494
79high-density lipoprotein particle remodeling (GO:0034375)3.41222983
80maturation of SSU-rRNA (GO:0030490)3.41128027
81tetrahydrofolate metabolic process (GO:0046653)3.41078177
82primary alcohol catabolic process (GO:0034310)3.40826895
83lysine metabolic process (GO:0006553)3.40779464
84lysine catabolic process (GO:0006554)3.40779464
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.40044366
86arginine metabolic process (GO:0006525)3.39471004
87reverse cholesterol transport (GO:0043691)3.39099832
88aromatic amino acid family metabolic process (GO:0009072)3.38570567
89ribosomal large subunit biogenesis (GO:0042273)3.38496775
90cellular amino acid catabolic process (GO:0009063)3.37680455
91linoleic acid metabolic process (GO:0043651)3.34167327
92proline biosynthetic process (GO:0006561)3.32784698
93chaperone-mediated protein transport (GO:0072321)3.31119460
94DNA strand elongation involved in DNA replication (GO:0006271)3.30735787
95ATP synthesis coupled proton transport (GO:0015986)3.27786611
96energy coupled proton transport, down electrochemical gradient (GO:0015985)3.27786611
97DNA strand elongation (GO:0022616)3.25844558
98nucleotide-sugar biosynthetic process (GO:0009226)3.25717448
99ribosome assembly (GO:0042255)3.25667113
100peptidyl-histidine modification (GO:0018202)3.25052462
101positive regulation of lipid catabolic process (GO:0050996)3.24240800
102phospholipid homeostasis (GO:0055091)3.23576266
103complement activation (GO:0006956)3.22238929
104response to phenylpropanoid (GO:0080184)3.21406317
105protein activation cascade (GO:0072376)3.20757079
106cellular component biogenesis (GO:0044085)3.19463845
107regulation of translational fidelity (GO:0006450)3.17479071
108viral transcription (GO:0019083)3.16938663
109rRNA processing (GO:0006364)3.16621754
110one-carbon metabolic process (GO:0006730)3.15999076
111low-density lipoprotein particle remodeling (GO:0034374)3.15374506
112regulation of plasminogen activation (GO:0010755)3.14491275
113negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.14230133
114negative regulation of ligase activity (GO:0051352)3.14230133
115protein targeting to mitochondrion (GO:0006626)3.14080782
116translational termination (GO:0006415)3.13857875
117meiotic chromosome segregation (GO:0045132)3.12470873
118short-chain fatty acid metabolic process (GO:0046459)3.11687627
119imidazole-containing compound metabolic process (GO:0052803)3.09574058
120mitochondrial RNA metabolic process (GO:0000959)3.09131852
121negative regulation of fatty acid biosynthetic process (GO:0045717)3.07970973
122nucleobase biosynthetic process (GO:0046112)3.07355600
123mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.06860610
124establishment of protein localization to mitochondrial membrane (GO:0090151)3.06405122
125regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.05563418
126anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05056706
127translation (GO:0006412)3.04941617
128spliceosomal snRNP assembly (GO:0000387)3.04836110
129chromatin remodeling at centromere (GO:0031055)3.04409450
130CENP-A containing nucleosome assembly (GO:0034080)3.04288328
131dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.04043140
132negative regulation of lipase activity (GO:0060192)3.03826078
133nucleoside transmembrane transport (GO:1901642)3.02962576
134respiratory chain complex IV assembly (GO:0008535)3.02372500
135glutamine family amino acid biosynthetic process (GO:0009084)3.01559027
136biotin metabolic process (GO:0006768)3.01462561
137bile acid and bile salt transport (GO:0015721)3.01304798
138heme transport (GO:0015886)3.01233666
139regulation of nuclear cell cycle DNA replication (GO:0033262)3.00652453
140telomere maintenance via semi-conservative replication (GO:0032201)2.99894581
141heterochromatin organization (GO:0070828)2.99806799
142ethanol metabolic process (GO:0006067)2.98845818
143cellular biogenic amine catabolic process (GO:0042402)2.98827092
144amine catabolic process (GO:0009310)2.98827092
145positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.98472535
146rRNA metabolic process (GO:0016072)2.98462236
147regulation of cholesterol homeostasis (GO:2000188)2.97885145
148establishment of integrated proviral latency (GO:0075713)2.97874597
149establishment of protein localization to mitochondrion (GO:0072655)2.97793200
150folic acid metabolic process (GO:0046655)2.97692550
151tRNA modification (GO:0006400)2.97530515
152opsonization (GO:0008228)2.97010935
153tRNA methylation (GO:0030488)2.95273551
154mitotic metaphase plate congression (GO:0007080)2.95224879
155formation of translation preinitiation complex (GO:0001731)2.94430621
156rRNA transcription (GO:0009303)2.88213078
157ribosomal small subunit assembly (GO:0000028)2.88089823
158nucleobase-containing small molecule interconversion (GO:0015949)2.87674652
159purine nucleobase biosynthetic process (GO:0009113)2.84722445
160translational initiation (GO:0006413)2.81804292
161respiratory electron transport chain (GO:0022904)2.81800736
162DNA damage response, detection of DNA damage (GO:0042769)2.81544122
163electron transport chain (GO:0022900)2.80717382
164DNA replication initiation (GO:0006270)2.80094010
165ncRNA processing (GO:0034470)2.77421852
166translational elongation (GO:0006414)2.76117210
167protein localization to chromosome, centromeric region (GO:0071459)2.75556414
168SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.75331796
169protein localization to mitochondrion (GO:0070585)2.74074255
170tRNA processing (GO:0008033)2.73359877
171pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.70578190
172cotranslational protein targeting to membrane (GO:0006613)2.69968743
173transcription from mitochondrial promoter (GO:0006390)2.69577360
174regulation of cellular amino acid metabolic process (GO:0006521)2.68326336
175mitochondrial respiratory chain complex assembly (GO:0033108)2.67734127
176protein targeting to ER (GO:0045047)2.67731786
177transcription from RNA polymerase I promoter (GO:0006360)2.66719946
178tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.66679059
179RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.66679059
180tRNA metabolic process (GO:0006399)2.66117199
181positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.65223506
182mitotic nuclear envelope reassembly (GO:0007084)2.64765795
183nuclear envelope reassembly (GO:0031468)2.64765795
184mitochondrion morphogenesis (GO:0070584)2.64263583
185base-excision repair, AP site formation (GO:0006285)2.63959195
186ncRNA metabolic process (GO:0034660)2.63872541
187ncRNA 3-end processing (GO:0043628)2.63325283
188cytochrome complex assembly (GO:0017004)2.62525947
189cullin deneddylation (GO:0010388)2.62458747
190peptidyl-arginine omega-N-methylation (GO:0035247)2.61591613
191UTP biosynthetic process (GO:0006228)2.61109706
192pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.59942769
193purine ribonucleotide transport (GO:0015868)2.59782821
194prenylation (GO:0097354)10.5474566
195protein prenylation (GO:0018342)10.5474566

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse9.80046989
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.94255755
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.52447652
4RXR_22158963_ChIP-Seq_LIVER_Mouse5.24757679
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.81728065
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.14094202
7ESR1_15608294_ChIP-ChIP_MCF-7_Human3.97448227
8E2F7_22180533_ChIP-Seq_HELA_Human3.61473371
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.41319404
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.33957472
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.29560556
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.20207991
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.08384972
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.94412424
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.85744770
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.74006395
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.67600379
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.65117187
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58587818
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.55602800
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.33639507
22TRIM28_21343339_ChIP-Seq_HEK293_Human2.26188993
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.20943324
24CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.19870452
25* MYC_18555785_ChIP-Seq_MESCs_Mouse2.19125951
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.14528015
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.12465226
28GABP_19822575_ChIP-Seq_HepG2_Human2.04881357
29* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02285699
30HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95259675
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93371143
32ZNF263_19887448_ChIP-Seq_K562_Human1.85000760
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.82565502
34TCF3_18692474_ChIP-Seq_MEFs_Mouse1.74400966
35AR_21909140_ChIP-Seq_LNCAP_Human1.70602112
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69102428
37* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.68224614
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.67083627
39DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.65879720
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65384312
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.63436096
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.62686865
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62248797
44CLOCK_20551151_ChIP-Seq_293T_Human1.61892764
45CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.55808895
46CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.53432332
47* RACK7_27058665_Chip-Seq_MCF-7_Human1.51642619
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.51611018
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50466225
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50146103
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43181688
52TCF3_18692474_ChIP-Seq_MESCs_Mouse1.42538146
53* VDR_21846776_ChIP-Seq_THP-1_Human1.42092532
54XRN2_22483619_ChIP-Seq_HELA_Human1.40894618
55* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.40035687
56* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.39994110
57* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38795758
58BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.38512292
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.38464614
60* FOXP1_21924763_ChIP-Seq_HESCs_Human1.38170959
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.36131090
62P68_20966046_ChIP-Seq_HELA_Human1.34911808
63* TET1_21451524_ChIP-Seq_MESCs_Mouse1.33191723
64TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28225686
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27043204
66* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26980861
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26809387
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26716305
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26314782
70MYC_18358816_ChIP-ChIP_MESCs_Mouse1.25103497
71SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.25013492
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24105317
73SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.22302717
74TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.19936340
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19599041
76ATF3_27146783_Chip-Seq_COLON_Human1.18309428
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15776161
78MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15352157
79LXR_22292898_ChIP-Seq_THP-1_Human1.14440916
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13801532
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.11490079
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10238805
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08219327
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07188125
85MYC_22102868_ChIP-Seq_BL_Human1.06134074
86CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05544550
87RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04050384
88ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03251421
89EGR1_19374776_ChIP-ChIP_THP-1_Human1.03201189
90SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02468916
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01690828
92CHD1_26751641_Chip-Seq_LNCaP_Human1.01478052
93RARA_24833708_ChIP-Seq_LIVER_Mouse1.01003357
94* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00875448
95* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00044012
96RARB_24833708_ChIP-Seq_LIVER_Mouse0.99141336
97PHF8_20622854_ChIP-Seq_HELA_Human0.98735151
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98458413
99STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97350493
100TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97102300
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96860903
102* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96619085
103TP63_19390658_ChIP-ChIP_HaCaT_Human0.96613057
104ERG_21242973_ChIP-ChIP_JURKAT_Human0.94968826
105* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94829667
106E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94714562
107POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92633644
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92279450
109MYC_18940864_ChIP-ChIP_HL60_Human0.91711979
110AR_21572438_ChIP-Seq_LNCaP_Human0.89342528
111SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89199822
112STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86769763
113OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86121699
114EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.85564022
115BRD4_27068464_Chip-Seq_AML-cells_Mouse0.83784288
116* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81781259
117TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.81437859
118* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.81370532
119CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.80787017
120CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.79845434
121CREB1_15753290_ChIP-ChIP_HEK293T_Human0.79226031
122SOX2_18692474_ChIP-Seq_MESCs_Mouse0.78237222
123TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.77577453
124HNF4A_19822575_ChIP-Seq_HepG2_Human0.77395830
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77147662
126IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.76550022
127MYCN_18555785_ChIP-Seq_MESCs_Mouse0.76278982
128PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75118212
129RXRA_24833708_ChIP-Seq_LIVER_Mouse0.74268642
130NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.73728915
131NANOG_18692474_ChIP-Seq_MEFs_Mouse0.72790413
132ELK1_19687146_ChIP-ChIP_HELA_Human0.70487384
133FOXO3_23340844_ChIP-Seq_DLD1_Human0.70156556
134TTF2_22483619_ChIP-Seq_HELA_Human0.68453921
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.68447888
136STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.67598644
137PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.67214034
138* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.67138583
139SOX2_18555785_ChIP-Seq_MESCs_Mouse0.66190512
140DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.66140145
141CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.63680881
142* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.59756602
143FOXP3_21729870_ChIP-Seq_TREG_Human0.59471066
144DCP1A_22483619_ChIP-Seq_HELA_Human0.59444951
145FOXA2_19822575_ChIP-Seq_HepG2_Human0.59257370
146SOX9_24532713_ChIP-Seq_HFSC_Mouse0.59068934
147VDR_23849224_ChIP-Seq_CD4+_Human0.58852527
148CSB_26484114_Chip-Seq_FIBROBLAST_Human0.57988377
149POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.57458155
150ZFX_18555785_ChIP-Seq_MESCs_Mouse0.56554298
151PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.54689116
152KDM5A_27292631_Chip-Seq_BREAST_Human0.53977950

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.95335867
2MP0009379_abnormal_foot_pigmentation6.47441788
3MP0005360_urolithiasis5.35946327
4MP0005085_abnormal_gallbladder_physiolo5.02694648
5MP0003693_abnormal_embryo_hatching4.09471395
6MP0005365_abnormal_bile_salt3.89576899
7MP0003111_abnormal_nucleus_morphology3.50314613
8MP0008875_abnormal_xenobiotic_pharmacok3.32396941
9MP0003806_abnormal_nucleotide_metabolis3.17283348
10MP0003252_abnormal_bile_duct2.81461933
11MP0003077_abnormal_cell_cycle2.77968721
12MP0010329_abnormal_lipoprotein_level2.61470886
13MP0008058_abnormal_DNA_repair2.51087755
14MP0005083_abnormal_biliary_tract2.46144614
15MP0008438_abnormal_cutaneous_collagen2.44438092
16MP0002138_abnormal_hepatobiliary_system2.31295374
17MP0003868_abnormal_feces_composition2.25044214
18MP0005332_abnormal_amino_acid2.24644421
19MP0003941_abnormal_skin_development2.17805034
20MP0003303_peritoneal_inflammation2.06782297
21MP0005171_absent_coat_pigmentation2.01036164
22MP0002254_reproductive_system_inflammat1.94558107
23MP0004381_abnormal_hair_follicle1.91575120
24MP0003724_increased_susceptibility_to1.91343964
25MP0000609_abnormal_liver_physiology1.90342478
26MP0003136_yellow_coat_color1.78834389
27MP0004019_abnormal_vitamin_homeostasis1.73363908
28MP0003705_abnormal_hypodermis_morpholog1.69973147
29MP0009384_cardiac_valve_regurgitation1.67296096
30MP0004185_abnormal_adipocyte_glucose1.65454114
31MP0009053_abnormal_anal_canal1.63103961
32MP0006035_abnormal_mitochondrial_morpho1.60409174
33MP0005666_abnormal_adipose_tissue1.57626665
34MP0001188_hyperpigmentation1.56358184
35MP0002118_abnormal_lipid_homeostasis1.55663334
36MP0005174_abnormal_tail_pigmentation1.55333079
37MP0002160_abnormal_reproductive_system1.53935579
38MP0001666_abnormal_nutrient_absorption1.52647949
39MP0003786_premature_aging1.51452493
40MP0005275_abnormal_skin_tensile1.51314673
41MP0003300_gastrointestinal_ulcer1.47842404
42MP0000350_abnormal_cell_proliferation1.47299370
43MP0002163_abnormal_gland_morphology1.46310860
44MP0003011_delayed_dark_adaptation1.43112039
45MP0009840_abnormal_foam_cell1.41644591
46MP0001873_stomach_inflammation1.40320182
47MP0004233_abnormal_muscle_weight1.40302958
48MP0005220_abnormal_exocrine_pancreas1.38962934
49MP0000358_abnormal_cell_content/1.38794130
50MP0004130_abnormal_muscle_cell1.35391609
51MP0001730_embryonic_growth_arrest1.34595883
52MP0010234_abnormal_vibrissa_follicle1.33373010
53MP0003195_calcinosis1.33370939
54MP0001697_abnormal_embryo_size1.32324418
55MP0002060_abnormal_skin_morphology1.31890932
56MP0001986_abnormal_taste_sensitivity1.31853435
57MP0006036_abnormal_mitochondrial_physio1.30086111
58MP0005380_embryogenesis_phenotype1.29727318
59MP0001672_abnormal_embryogenesis/_devel1.29727318
60MP0005319_abnormal_enzyme/_coenzyme1.28031728
61MP0000678_abnormal_parathyroid_gland1.27892303
62MP0005584_abnormal_enzyme/coenzyme_acti1.26721523
63MP0009697_abnormal_copulation1.24845463
64MP0003123_paternal_imprinting1.23867122
65MP0006292_abnormal_olfactory_placode1.22843562
66MP0002796_impaired_skin_barrier1.21735848
67MP0002080_prenatal_lethality1.21225259
68MP0002736_abnormal_nociception_after1.19940152
69MP0009763_increased_sensitivity_to1.18708574
70MP0005423_abnormal_somatic_nervous1.17067506
71MP0000537_abnormal_urethra_morphology1.15954345
72MP0002085_abnormal_embryonic_tissue1.14609717
73MP0003984_embryonic_growth_retardation1.14261125
74MP0002971_abnormal_brown_adipose1.13884159
75MP0000750_abnormal_muscle_regeneration1.10421832
76MP0001346_abnormal_lacrimal_gland1.09647560
77MP0002088_abnormal_embryonic_growth/wei1.08889250
78MP0000598_abnormal_liver_morphology1.08808366
79MP0000579_abnormal_nail_morphology1.05598653
80MP0001919_abnormal_reproductive_system1.04780735
81MP0003937_abnormal_limbs/digits/tail_de1.04764654
82MP0003315_abnormal_perineum_morphology1.03988018
83MP0005248_abnormal_Harderian_gland1.03446310
84MP0002210_abnormal_sex_determination1.02670492
85MP0005330_cardiomyopathy1.02627229
86MP0000538_abnormal_urinary_bladder1.00625044
87MP0008057_abnormal_DNA_replication0.99782211
88MP0002084_abnormal_developmental_patter0.98722995
89MP0003656_abnormal_erythrocyte_physiolo0.97907988
90MP0002938_white_spotting0.97876399
91MP0000313_abnormal_cell_death0.95599802
92MP0002697_abnormal_eye_size0.93830382
93MP0003436_decreased_susceptibility_to0.92888436
94MP0005395_other_phenotype0.92857874
95MP0001542_abnormal_bone_strength0.92238634
96MP0000467_abnormal_esophagus_morphology0.92224488
97MP0005647_abnormal_sex_gland0.92024774
98MP0010307_abnormal_tumor_latency0.91629953
99MP0004133_heterotaxia0.90717691
100MP0004197_abnormal_fetal_growth/weight/0.90514572
101MP0009672_abnormal_birth_weight0.89879012
102MP0002086_abnormal_extraembryonic_tissu0.89068567
103MP0005389_reproductive_system_phenotype0.86410132
104MP0000049_abnormal_middle_ear0.86247262
105MP0001243_abnormal_dermal_layer0.86023854
106MP0001756_abnormal_urination0.85220352
107MP0004858_abnormal_nervous_system0.81899932
108MP0000762_abnormal_tongue_morphology0.81611434
109MP0009115_abnormal_fat_cell0.81491852
110MP0005375_adipose_tissue_phenotype0.81214506
111MP0000613_abnormal_salivary_gland0.80258696
112MP0002098_abnormal_vibrissa_morphology0.79825978
113MP0003755_abnormal_palate_morphology0.79762804
114MP0002970_abnormal_white_adipose0.78275577
115MP0003186_abnormal_redox_activity0.77296842
116MP0001968_abnormal_touch/_nociception0.77226903
117MP0002249_abnormal_larynx_morphology0.75831433
118MP0003453_abnormal_keratinocyte_physiol0.74374299
119MP0009765_abnormal_xenobiotic_induced0.74316328
120MP0000427_abnormal_hair_cycle0.74222130
121MP0001145_abnormal_male_reproductive0.73799436
122MP0001502_abnormal_circadian_rhythm0.73373360
123MP0008789_abnormal_olfactory_epithelium0.73079812
124MP0005084_abnormal_gallbladder_morpholo0.72167955
125MP0005334_abnormal_fat_pad0.70374113
126MP0009764_decreased_sensitivity_to0.70315795
127MP0002006_tumorigenesis0.69955587
128MP0009643_abnormal_urine_homeostasis0.69819032
129MP0002234_abnormal_pharynx_morphology0.69730073
130MP0005501_abnormal_skin_physiology0.68950646
131MP0000490_abnormal_crypts_of0.68552653
132MP0002089_abnormal_postnatal_growth/wei0.68409648
133MP0001293_anophthalmia0.68239287
134MP0001661_extended_life_span0.65788206
135MP0008932_abnormal_embryonic_tissue0.64957245
136MP0003828_pulmonary_edema0.64932659
137MP0005636_abnormal_mineral_homeostasis0.62802000
138MP0005076_abnormal_cell_differentiation0.61726388
139MP0008469_abnormal_protein_level0.60991399
140MP0005670_abnormal_white_adipose0.59697706
141MP0010030_abnormal_orbit_morphology0.56520042
142MP0001216_abnormal_epidermal_layer0.56459700
143MP0005508_abnormal_skeleton_morphology0.54506173
144MP0000377_abnormal_hair_follicle0.54482610
145MP0005595_abnormal_vascular_smooth0.54338429
146MP0002078_abnormal_glucose_homeostasis0.52885500
147MP0005451_abnormal_body_composition0.51573799
148MP0010771_integument_phenotype0.51199626
149MP0002166_altered_tumor_susceptibility0.50979704
150MP0001881_abnormal_mammary_gland0.50442574
151MP0001764_abnormal_homeostasis0.49032429
152MP0004957_abnormal_blastocyst_morpholog0.48071594
153MP0009642_abnormal_blood_homeostasis0.47948386
154MP0001915_intracranial_hemorrhage0.47919537
155MP0004043_abnormal_pH_regulation0.47914590
156MP0002282_abnormal_trachea_morphology0.46565548
157MP0010094_abnormal_chromosome_stability0.45585271
158MP0000639_abnormal_adrenal_gland0.45553486
159MP0000627_abnormal_mammary_gland0.44654688
160MP0003448_altered_tumor_morphology0.43811032
161MP0005023_abnormal_wound_healing0.43804264
162MP0008007_abnormal_cellular_replicative0.43553847
163MP0003718_maternal_effect0.43123543
164MP0005410_abnormal_fertilization0.42433410
165MP0002111_abnormal_tail_morphology0.41954817
166MP0005266_abnormal_metabolism0.41381592

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.71163039
2Xanthomatosis (HP:0000991)5.49107989
3Prolonged partial thromboplastin time (HP:0003645)5.31995407
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.24125152
5Complement deficiency (HP:0004431)5.23906787
6Intrahepatic cholestasis (HP:0001406)5.05346967
7Abnormality of complement system (HP:0005339)4.96881635
8Abnormal hemoglobin (HP:0011902)4.92560735
9Hypoalphalipoproteinemia (HP:0003233)4.86959022
10Abnormality of aromatic amino acid family metabolism (HP:0004338)4.81129237
11Testicular atrophy (HP:0000029)4.80750345
12Hypobetalipoproteinemia (HP:0003563)4.67772216
13Hypolipoproteinemia (HP:0010981)4.50568725
14Premature rupture of membranes (HP:0001788)4.33825400
15Hyperglycinemia (HP:0002154)4.20420331
16Protrusio acetabuli (HP:0003179)4.13806263
17Myocardial infarction (HP:0001658)4.12593282
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.93509497
19Increased hepatocellular lipid droplets (HP:0006565)3.83080591
20Hyperlipoproteinemia (HP:0010980)3.75204687
21Abnormality of glycine metabolism (HP:0010895)3.68794760
22Abnormality of serine family amino acid metabolism (HP:0010894)3.68794760
23Epidermoid cyst (HP:0200040)3.67006318
24Slow saccadic eye movements (HP:0000514)3.65882525
25Lipid accumulation in hepatocytes (HP:0006561)3.60909288
26Birth length less than 3rd percentile (HP:0003561)3.58100874
27Joint hemorrhage (HP:0005261)3.56194243
28Abnormality of pyrimidine metabolism (HP:0004353)3.55231415
29Hyperammonemia (HP:0001987)3.54026257
30Tongue fasciculations (HP:0001308)3.51983039
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.50797749
32Abnormality of the common coagulation pathway (HP:0010990)3.48309452
33Rib fusion (HP:0000902)3.47726066
34Hyperglycinuria (HP:0003108)3.45153015
35Delayed CNS myelination (HP:0002188)3.34251602
36Renal Fanconi syndrome (HP:0001994)3.30628581
37Abnormal number of erythroid precursors (HP:0012131)3.25802037
38Abnormality of cells of the erythroid lineage (HP:0012130)3.17381925
39Muscle fibrillation (HP:0010546)3.15099095
40Acute necrotizing encephalopathy (HP:0006965)3.12449222
41Abnormal mitochondria in muscle tissue (HP:0008316)3.12087172
42Increased intramyocellular lipid droplets (HP:0012240)3.09224781
43Poikiloderma (HP:0001029)3.09215173
44Acute encephalopathy (HP:0006846)3.06257627
45Type I transferrin isoform profile (HP:0003642)3.01232017
46Vaginal fistula (HP:0004320)2.96512969
47Abnormality of glutamine family amino acid metabolism (HP:0010902)2.94232862
48Mitochondrial inheritance (HP:0001427)2.94182104
49Abnormality of methionine metabolism (HP:0010901)2.92614231
50Abnormality of aspartate family amino acid metabolism (HP:0010899)2.90945969
51Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.89761823
52Squamous cell carcinoma (HP:0002860)2.88992256
53Increased CSF lactate (HP:0002490)2.87657911
54Amniotic constriction ring (HP:0009775)2.86364246
55Abnormality of placental membranes (HP:0011409)2.86364246
56Rectal fistula (HP:0100590)2.81443444
57Rectovaginal fistula (HP:0000143)2.81443444
58Reduced antithrombin III activity (HP:0001976)2.81395238
59Decreased activity of mitochondrial respiratory chain (HP:0008972)2.81072063
60Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.81072063
61Ketosis (HP:0001946)2.79356070
62Abnormality of the Achilles tendon (HP:0005109)2.76128459
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.74818164
64Increased muscle lipid content (HP:0009058)2.72723228
65Abnormality of serum amino acid levels (HP:0003112)2.70985690
66Absent thumb (HP:0009777)2.70591247
67Progressive muscle weakness (HP:0003323)2.70213075
68Acanthocytosis (HP:0001927)2.69488636
69Esophageal varix (HP:0002040)2.65610960
70Abnormality of sulfur amino acid metabolism (HP:0004339)2.65538814
71Aplasia of the musculature (HP:0100854)2.62849139
72Patellar aplasia (HP:0006443)2.61989367
73Biconcave vertebral bodies (HP:0004586)2.61120839
74Microvesicular hepatic steatosis (HP:0001414)2.59659929
75Abnormal delivery (HP:0001787)2.58962456
76Hypoglycemic coma (HP:0001325)2.57678703
77Fat malabsorption (HP:0002630)2.56323631
78Toxemia of pregnancy (HP:0100603)2.55374686
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.54779312
80Abnormal protein N-linked glycosylation (HP:0012347)2.54779312
81Abnormal protein glycosylation (HP:0012346)2.54779312
82Abnormal glycosylation (HP:0012345)2.54779312
83Reticulocytopenia (HP:0001896)2.53337865
84Aplasia/Hypoplasia of the patella (HP:0006498)2.53274433
85Spontaneous abortion (HP:0005268)2.52229000
86Intestinal fistula (HP:0100819)2.51713642
87Gingival bleeding (HP:0000225)2.50632668
88Respiratory difficulties (HP:0002880)2.49563987
89Congenital, generalized hypertrichosis (HP:0004540)2.48440835
90Hypoplasia of the pons (HP:0012110)2.45949777
91Increased serum lactate (HP:0002151)2.45716431
92Cardiovascular calcification (HP:0011915)2.42705503
93Achilles tendon contracture (HP:0001771)2.41984907
94Vascular calcification (HP:0004934)2.39146731
95Exercise intolerance (HP:0003546)2.38322667
96Aplasia/Hypoplasia of the sacrum (HP:0008517)2.37551403
97Cerebral edema (HP:0002181)2.37165883
98Menorrhagia (HP:0000132)2.35950843
99Popliteal pterygium (HP:0009756)2.35316380
100Hepatocellular necrosis (HP:0001404)2.34939311
101Ketoacidosis (HP:0001993)2.34903072
102Stomatitis (HP:0010280)2.33585004
103Breast hypoplasia (HP:0003187)2.33506559
104Abnormality of the pons (HP:0007361)2.32234461
105Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30445001
106Lactic acidosis (HP:0003128)2.27924551
107Pseudobulbar signs (HP:0002200)2.27636521
108Soft skin (HP:0000977)2.26969281
109Hyperglycemia (HP:0003074)2.26817386
110Abnormality of the intrinsic pathway (HP:0010989)2.25558255
111Megaloblastic anemia (HP:0001889)2.25360870
112Aplasia involving forearm bones (HP:0009822)2.24474250
113Absent forearm bone (HP:0003953)2.24474250
114Increased connective tissue (HP:0009025)2.24466152
115Absent radius (HP:0003974)2.22549946
116Abnormal trabecular bone morphology (HP:0100671)2.21251940
117Progressive macrocephaly (HP:0004481)2.19938395
118Skin nodule (HP:0200036)2.19449617
119Aplasia/Hypoplasia involving the musculature (HP:0001460)2.18237006
120Hypophosphatemic rickets (HP:0004912)2.17660031
121Sparse eyelashes (HP:0000653)2.17041454
122Facial hemangioma (HP:0000329)2.15804223
123Thyroid-stimulating hormone excess (HP:0002925)2.15504583
124Abnormality of nucleobase metabolism (HP:0010932)2.13556759
125Hepatocellular carcinoma (HP:0001402)2.11960232
126Hyperbilirubinemia (HP:0002904)2.11014062
127Hypoplastic pelvis (HP:0008839)2.09902426
128Pterygium (HP:0001059)2.09668407
129Sparse lateral eyebrow (HP:0005338)2.06845276
130Spastic diplegia (HP:0001264)2.06365543
131Recurrent gram-negative bacterial infections (HP:0005420)2.05423597
132Hepatic necrosis (HP:0002605)2.04680533
133Ulnar bowing (HP:0003031)2.01799181
134Exertional dyspnea (HP:0002875)2.01617868
135Abnormality of glycolysis (HP:0004366)2.00241479
136Short thumb (HP:0009778)1.99523605
137Delayed epiphyseal ossification (HP:0002663)1.99300059
138Thrombophlebitis (HP:0004418)1.99207358
139Chromsome breakage (HP:0040012)1.99196175
140Vertebral compression fractures (HP:0002953)1.95879314
141Abnormality of homocysteine metabolism (HP:0010919)1.95766426
142Homocystinuria (HP:0002156)1.95766426
143Macrocytic anemia (HP:0001972)1.94935985
144Hypercholesterolemia (HP:0003124)1.94026207
145Microretrognathia (HP:0000308)1.93711262
146Insulin resistance (HP:0000855)1.93099424
147Type I diabetes mellitus (HP:0100651)1.93043789
148Alveolar cell carcinoma (HP:0006519)1.92089121
149Aplasia involving bones of the extremities (HP:0009825)1.92074236
150Aplasia involving bones of the upper limbs (HP:0009823)1.92074236
151Aplasia of the phalanges of the hand (HP:0009802)1.92074236
152Increased serum pyruvate (HP:0003542)1.91677553
153Concave nail (HP:0001598)1.91357688
154Septate vagina (HP:0001153)1.91051420
155Mitral stenosis (HP:0001718)1.90825173
156Dyschromatopsia (HP:0007641)1.90655950
157Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88875084
158Abnormality of alanine metabolism (HP:0010916)1.88875084
159Hyperalaninemia (HP:0003348)1.88875084
160Polycythemia (HP:0001901)1.87414434
161Rough bone trabeculation (HP:0100670)1.87258394
162Acanthosis nigricans (HP:0000956)1.86174824
163Ragged-red muscle fibers (HP:0003200)1.86109934
164Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.84771269
165Conjunctival telangiectasia (HP:0000524)1.84601843
166Neoplasm of the tracheobronchial system (HP:0100552)1.83249226
167Abnormalities of placenta or umbilical cord (HP:0001194)1.83229971
168Obstructive sleep apnea (HP:0002870)1.82808545
169Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82728082
170Hyperinsulinemic hypoglycemia (HP:0000825)1.80880256
171Abnormality of the distal phalanges of the toes (HP:0010182)1.80760241
172Lethargy (HP:0001254)1.80732061
173Large earlobe (HP:0009748)1.80725999
174Hypoglycemic seizures (HP:0002173)1.78751565
175Confusion (HP:0001289)1.78643836
176Facial cleft (HP:0002006)1.78496937
177Trismus (HP:0000211)1.78155509
178Mitral valve prolapse (HP:0001634)1.77343948
179Diminished movement (HP:0002374)1.76656917
180Distal lower limb amyotrophy (HP:0008944)1.76482615
181Multiple enchondromatosis (HP:0005701)1.76129498
182Peritonitis (HP:0002586)1.75885721
183Gout (HP:0001997)1.75785732
184Late onset (HP:0003584)1.75206887
185Rickets (HP:0002748)1.74257195
186Akinesia (HP:0002304)1.73975020
187Progressive external ophthalmoplegia (HP:0000590)1.73433723
188Thin bony cortex (HP:0002753)1.73375028
189Lip pit (HP:0100267)1.73235343
190Pancreatitis (HP:0001733)1.73122879
191Seborrheic dermatitis (HP:0001051)1.72941251
192Distal lower limb muscle weakness (HP:0009053)1.72665317
193Prenatal maternal abnormality (HP:0002686)1.70663851

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK18.58398716
2MKNK24.00520239
3VRK23.97946165
4EIF2AK13.51330963
5NEK92.94352406
6STK162.79102414
7NME12.68319911
8ZAK2.60608125
9SMG12.42758851
10WEE12.32326987
11MAPK152.25325313
12BCKDK2.24910674
13TESK22.12940543
14PKN22.10999002
15PDK22.08802585
16CDC72.02903666
17FES1.92446278
18BUB11.89290235
19MUSK1.87986331
20FER1.82510071
21ARAF1.82109210
22FGFR41.80430186
23MKNK11.79203051
24NME21.79031480
25CDK91.77435529
26ERBB41.77033062
27FLT31.75721490
28TAF11.68709215
29EPHA21.46854963
30PBK1.44090378
31TSSK61.35329736
32TAOK21.34693446
33MST41.34200521
34PIM21.32932227
35ICK1.31524073
36RPS6KB21.28840438
37STK41.28624095
38VRK11.28327791
39MAPK111.26962412
40DYRK1B1.26325999
41PIM11.23512437
42PAK41.22299333
43EIF2AK31.18079683
44MET1.14728863
45CSK1.12519278
46PKN11.11581563
47PRKCI1.10858702
48LATS11.09312385
49RPS6KA51.06832155
50CDK71.02778951
51MAP3K111.02473670
52MAPKAPK31.01721135
53DAPK31.01419970
54BRSK10.99260165
55CDK60.98806727
56PRKD30.96558443
57ERBB20.95067291
58JAK20.94780594
59IRAK30.93450077
60MAPK40.91878649
61FGFR30.91534480
62NUAK10.90951730
63IRAK10.90724416
64MAP3K90.88790679
65SRPK10.86470408
66PLK30.86279557
67PRKAA20.85401533
68BRAF0.84489595
69ATR0.83937322
70INSRR0.82114254
71MAP2K40.81729412
72TRIB30.81501731
73CDK120.80572609
74NLK0.80211974
75SIK10.80034038
76MAP3K100.78167694
77CAMK1G0.77633460
78NEK20.74263393
79EEF2K0.73672186
80CSNK1G30.72726367
81CAMK1D0.72598229
82CSNK1G10.70682295
83ILK0.68479917
84DYRK30.67989159
85YES10.65681835
86CHEK10.65471764
87CSNK1A1L0.65436712
88EPHA30.64113625
89TRIM280.63598314
90EIF2AK20.63397624
91AURKA0.61386245
92FRK0.60685997
93STK110.58426086
94STK30.58211703
95DAPK10.57990946
96CDK80.57944047
97PDK40.56412918
98PDK30.56412918
99PAK10.55810601
100PLK10.55742995
101TYK20.55240966
102MAP3K80.54564865
103MELK0.54465538
104ABL20.53648587
105IRAK20.53336783
106AKT20.52769499
107DYRK1A0.51854878
108MAP4K10.51662384
109MTOR0.47725166
110TESK10.46099358
111CDK40.45270225
112CDK10.44715505
113TAOK10.44705491
114NEK10.44611313
115TAOK30.44227980
116FGFR20.43073981
117ALK0.42422111
118PTK20.41777889
119CHEK20.41713866
120RAF10.40726548
121STK390.40113043
122JAK10.39414771
123CSNK1G20.38712206
124PRKD20.38163810
125MAPKAPK50.37886915
126CSNK2A10.37455643
127CSNK1E0.35193320
128CSNK2A20.34066163
129BMX0.34058279
130TEC0.33832907
131CDK20.33406306
132NEK60.32341161
133AURKB0.31575368
134ADRBK10.31277193
135MAP2K60.30550712
136MAP2K20.30469493
137DYRK20.30322269
138LATS20.30216586
139EGFR0.30019169
140SCYL20.28914858
141SGK20.27967597
142WNK40.24757998
143BRSK20.24339946
144CAMK2G0.22846030
145TTK0.22642139
146ABL10.20454729
147PRKACG0.20315101
148MAP3K50.20178354
149HCK0.20140264
150PIK3CG0.20041296
151LCK0.19949169
152LYN0.18802611
153GSK3A0.18755836
154ATM0.18557484
155MST1R0.17837417
156RET0.17223602

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.34008146
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.73457430
3Systemic lupus erythematosus_Homo sapiens_hsa053223.69947818
4Proteasome_Homo sapiens_hsa030503.33643661
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.28454621
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.94028988
7Fatty acid degradation_Homo sapiens_hsa000712.75495123
8Complement and coagulation cascades_Homo sapiens_hsa046102.61430548
9Arginine biosynthesis_Homo sapiens_hsa002202.60821759
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.52298793
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.41905065
12Oxidative phosphorylation_Homo sapiens_hsa001902.31237582
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.29387575
14Base excision repair_Homo sapiens_hsa034102.28684116
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24669039
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.12364114
17One carbon pool by folate_Homo sapiens_hsa006702.09221980
18Tryptophan metabolism_Homo sapiens_hsa003802.03636908
19Fatty acid metabolism_Homo sapiens_hsa012122.02212757
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01682489
21Parkinsons disease_Homo sapiens_hsa050121.97103352
22PPAR signaling pathway_Homo sapiens_hsa033201.90168797
23Huntingtons disease_Homo sapiens_hsa050161.79665568
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.77872656
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.77480371
26Vitamin B6 metabolism_Homo sapiens_hsa007501.74251430
27Fanconi anemia pathway_Homo sapiens_hsa034601.66649670
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64031569
29Propanoate metabolism_Homo sapiens_hsa006401.58395796
30Nucleotide excision repair_Homo sapiens_hsa034201.57920612
31Sulfur relay system_Homo sapiens_hsa041221.57432727
32Peroxisome_Homo sapiens_hsa041461.56261321
33Lysine degradation_Homo sapiens_hsa003101.55918235
34Fructose and mannose metabolism_Homo sapiens_hsa000511.55072884
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.54883275
36Retinol metabolism_Homo sapiens_hsa008301.54789076
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51680727
38Butanoate metabolism_Homo sapiens_hsa006501.50229505
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48623136
40Fatty acid biosynthesis_Homo sapiens_hsa000611.45960287
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.45588552
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.45587726
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.43731473
44Basal transcription factors_Homo sapiens_hsa030221.41578613
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40768782
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38408258
47Staphylococcus aureus infection_Homo sapiens_hsa051501.37047381
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36960148
49Chemical carcinogenesis_Homo sapiens_hsa052041.34115359
50beta-Alanine metabolism_Homo sapiens_hsa004101.33543283
51Biosynthesis of amino acids_Homo sapiens_hsa012301.32203235
52Pyruvate metabolism_Homo sapiens_hsa006201.31757129
53Starch and sucrose metabolism_Homo sapiens_hsa005001.28960196
54Alzheimers disease_Homo sapiens_hsa050101.28219814
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25570163
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23232071
57Ribosome_Homo sapiens_hsa030101.22871149
58Bile secretion_Homo sapiens_hsa049761.20479446
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16760197
60Purine metabolism_Homo sapiens_hsa002301.16352038
61Histidine metabolism_Homo sapiens_hsa003401.16110866
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15945335
63Folate biosynthesis_Homo sapiens_hsa007901.15086897
64Cysteine and methionine metabolism_Homo sapiens_hsa002701.13385117
65Non-homologous end-joining_Homo sapiens_hsa034501.11150976
66N-Glycan biosynthesis_Homo sapiens_hsa005101.10831274
67Selenocompound metabolism_Homo sapiens_hsa004501.09804915
68Carbon metabolism_Homo sapiens_hsa012001.08585158
69Maturity onset diabetes of the young_Homo sapiens_hsa049501.06734346
70Sulfur metabolism_Homo sapiens_hsa009201.06581402
71Fatty acid elongation_Homo sapiens_hsa000621.06083481
72Pentose phosphate pathway_Homo sapiens_hsa000301.05066208
73Alcoholism_Homo sapiens_hsa050341.04447419
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03688638
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01626176
76ABC transporters_Homo sapiens_hsa020100.98843985
77RNA degradation_Homo sapiens_hsa030180.98462334
78Steroid biosynthesis_Homo sapiens_hsa001000.97165693
79Protein export_Homo sapiens_hsa030600.93493017
80Tyrosine metabolism_Homo sapiens_hsa003500.91697800
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89649138
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87922288
83Phenylalanine metabolism_Homo sapiens_hsa003600.86381862
84Caffeine metabolism_Homo sapiens_hsa002320.85039254
85Vitamin digestion and absorption_Homo sapiens_hsa049770.83271783
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78620231
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75261673
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71896448
89Arginine and proline metabolism_Homo sapiens_hsa003300.71879272
90Sphingolipid metabolism_Homo sapiens_hsa006000.71061302
91mRNA surveillance pathway_Homo sapiens_hsa030150.70993115
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70177762
93Fat digestion and absorption_Homo sapiens_hsa049750.69918917
94Glycerolipid metabolism_Homo sapiens_hsa005610.61506333
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59773540
96Bladder cancer_Homo sapiens_hsa052190.57288302
97Basal cell carcinoma_Homo sapiens_hsa052170.51781211
98Hedgehog signaling pathway_Homo sapiens_hsa043400.51372970
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49426651
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48893114
101Hippo signaling pathway_Homo sapiens_hsa043900.47116088
102p53 signaling pathway_Homo sapiens_hsa041150.46142758
103Glutathione metabolism_Homo sapiens_hsa004800.45450608
104DNA replication_Homo sapiens_hsa030300.43378128
105Cardiac muscle contraction_Homo sapiens_hsa042600.41503711
106Prion diseases_Homo sapiens_hsa050200.35824164
107RNA transport_Homo sapiens_hsa030130.35592042
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35462842
109Viral carcinogenesis_Homo sapiens_hsa052030.35249768
110Thyroid cancer_Homo sapiens_hsa052160.34824905
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.31544284
112Metabolic pathways_Homo sapiens_hsa011000.30982441
113Mismatch repair_Homo sapiens_hsa034300.30090043
114Homologous recombination_Homo sapiens_hsa034400.28356016
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27817037
116Spliceosome_Homo sapiens_hsa030400.26217888
117Epstein-Barr virus infection_Homo sapiens_hsa051690.25488750
118Renin-angiotensin system_Homo sapiens_hsa046140.21348226
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21238361
120AMPK signaling pathway_Homo sapiens_hsa041520.16789718
121Pyrimidine metabolism_Homo sapiens_hsa002400.16488152
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.16084137
123Insulin signaling pathway_Homo sapiens_hsa049100.15645827
124Glucagon signaling pathway_Homo sapiens_hsa049220.15095843
125MicroRNAs in cancer_Homo sapiens_hsa052060.13025454
126Insulin resistance_Homo sapiens_hsa049310.12974267
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.12318538
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.11627841
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10694366
130Cell cycle_Homo sapiens_hsa041100.09827723
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.07476468
132RNA polymerase_Homo sapiens_hsa030200.06618665
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.05323508
134Hepatitis C_Homo sapiens_hsa051600.04966670
135Melanoma_Homo sapiens_hsa052180.04259032
136Dorso-ventral axis formation_Homo sapiens_hsa043200.03879819
137Jak-STAT signaling pathway_Homo sapiens_hsa046300.03065741
138Malaria_Homo sapiens_hsa051440.01054183
139Galactose metabolism_Homo sapiens_hsa00052-0.0261946

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